4-Day the Czech Republic Self-Drive Road Trip With Itinerary from Brno to Prague

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Photo of building in Denis Gardens in the center of Brno city, Czech Republic.
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Explore the best of the Czech Republic on a 4-day road trip! Uncover hidden gems and experience the rich culture firsthand as you journey through Brno, Telč, Prague, Český Krumlov, and Třeboň. This road trip itinerary in the Czech Republic seamlessly combines exploration with relaxation.

This perfectly planned road trip itinerary in the Czech Republic takes you through some of the best places to see in the country. You will spend 2 nights in Brno and 1 night in Prague. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in the Czech Republic. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have got you covered.

Upon arriving in Brno, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover the Czech Republic on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in the Czech Republic. Charles Bridge and Prague Astronomical Clock are just a couple of the bucket-list attractions that await your discovery. Marvel at the remarkable Špilberk Castle, learn more about the unique Náměstí Svobody, and immerse yourself in the vibrant atmosphere of The Castle Garden.

As you hit the open road and drive through Brno, Telč, Prague, Český Krumlov, and Třeboň, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of the Czech Republic. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in the Czech Republic.

Throughout your road trip in the Czech Republic, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in the Czech Republic.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodation, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in the Czech Republic fill up quickly, so book your spot early. Select a date and start planning your road trip in the Czech Republic today!

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Driver’s age is 30 - 65
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Day 1

Day 1

  • Brno - Arrival day
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  • Špilberk Castle
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Your road trip adventure in the Czech Republic begins as soon as you reach Brno and pick up your car. You’ll stay in Brno for 1 night and explore the best things to see and do, sample the local cuisine, and choose from a curated selection of the best hotels and places to stay in the city.

Brno is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out Špilberk Castle, or just taking a stroll in the city center. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

Make your way to your chosen hotel. Check-in typically starts between 2 and 4 PM in Brno. Make yourself at home and enjoy some downtime before heading out again.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Brno, it's often a good idea to reserve a table in advance.

Have a fantastic dining experience at U Štíra, a highly recommended choice for tonight's dinner. If you're looking to mix things up, Bistro Franz offers an enticing alternative with its varied menu. Additionally, Noem Arch Restaurant is worth considering. Renowned for satisfying diners, it’s an ideal option for tonight in Brno.

After enjoying a delightful dinner, why not delve into the vibrant local bar scene? You might want to spend the evening at Bar Naproti, a well-loved spot among locals and tourists. Or, head to Super Panda Circus. This bar boasts a welcoming environment that is perfect for winding down. You could also continue your night at Výčep Na Stojáka, another top-rated place in the area.

Raise a toast to the start of your 4-day road trip in the Czech Republic!

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Day 2

Day 2

  • Brno
  • Prague
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Drive 280 km, 3 hours 55 min

  • Villa Tugendhat
  • Telč château
  • Charles Bridge
  • Prague Astronomical Clock
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On day 2 of your exciting self-drive vacation in the Czech Republic, you’ll soak in the magnificence of 3 destinations, Brno, Telč, and Prague. When you’re not sightseeing, take time to relax at your selected hotel in Prague, where you’ll be staying for 1 night.

Enjoy the perfect balance of relaxation and exploration in Brno today. One of the most worthwhile attractions included on the itinerary is Villa Tugendhat. This UNESCO world heritage-listed museum will help you start your sightseeing on top. Then, take a leisurely stroll to Telč Château and learn what makes this visually striking castle unique.

Throughout the day, make sure to take breaks to appreciate the surroundings. Next up, visit the wondrous Charles Bridge. After exploring the historical landmark, head to Prague Astronomical Clock. This widely recognized historical landmark is a highlight in Brno.

At the end of the day, you will drive to Prague, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

As you explore more of Prague, you'll discover that its culinary landscape is as diverse as its attractions. Whether you're craving traditional dishes bursting with local flavors or innovative creations that push the boundaries of taste, you're sure to find a dining experience that satisfies your cravings.

Enjoy a delicious meal at U Tellerů, a highly-rated dining destination in Prague. If you're eager to try something different, consider Restaurace U Bansethů, another top spot with a tantalizing menu. You might also want to secure a reservation at Eska Restaurant and Bakery. With a reputation for consistently satisfying customers, it’s an excellent choice to enhance your stay in Prague this evening.

Continue your lively evening at Anonymous Shrink's Office, a perfect place for winding down or revving up the night, depending on which mood you’re in. Bar No. 7 - Prague is another excellent bar that offers a great selection of drinks to suit any mood. If you prefer to go somewhere else, Kontakt Bar ensures a night out tailored to your taste.

Relax and recharge in preparation for another adventurous day in the Czech Republic!

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Day 3

Day 3

  • Prague
  • Brno
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Drive 418 km, 5 hours 41 min

  • Český Krumlov Castle Tower
  • The Castle Garden
  • Třeboň v marcipánu
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On day 3 of your road trip in the Czech Republic, you will get a true taste of the freedom a self-drive vacation in Europe entails. Today’s travel plans include stops at the most scenic, wondrous, and interesting places in Český Krumlov and Třeboň. In the evening, you’ll end up in Brno, where you will stay for 1 night.

Today’s route brings family-friendly attractions, romantic experiences, and breathtaking views. The first attraction of today is Český Krumlov Castle Tower. This often recommended castle is a visually striking place to see in Prague. Continue your discovery at The Castle Garden, a visually striking castle with stories to tell.

As you stroll around Prague, take in the distinct atmosphere and learn what makes this town so unique. Maximize your sightseeing with a visit to Třeboň V Marcipánu. This locally appreciated museum offers a photogenic encounter with Prague. Whether you decide to get entrance tickets for all attractions or you prefer admiring from a distance, amazing experiences await on this day in Prague.

When you’re done exploring for the day, you’ll drive to your hotel in Brno. Check in and spend some time relaxing before you head out to tour the city.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Brno. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Treat yourself to a delicious dinner at Nok Nok Restaurace Brno, an excellent option for tonight's dining. Looking for something different? Sportovní areál Komec offers a tantalizing alternative with its diverse menu. And don’t miss Restaurace L'Eau Vive. With its reputation for pleasing customers, it’s a fantastic choice for tonight in Brno.

Continue your evening by exploring the vibrant nightlife scene at Jazzový Bar U Kouřícího Králíka, a prime destination for a thrilling night out. Also, don’t forget to check out Queen Luxury Hookah Club, a bar that offers unique local touches. Likewise, Shot Bar provides an excellent alternative for a fun evening.

Raise your glass and celebrate another amazing day of your road trip in the Czech Republic!

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Day 4

Day 4

  • Brno - Departure day
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  • Náměstí Svobody
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Day 4 of your road trip in the Czech Republic is your departure day. This is your chance to catch a last glimpse of Brno before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

If you're up for some more sightseeing, begin at Náměstí Svobody. This popular public square is a popular place to see in the city.

As your final day in the Czech Republic unfolds, enjoy a last-minute shopping spree in Brno's best shopping area, Avion Shopping Park. Enjoy finding the perfect gift or keepsake to remind you of your wonderful trip to the Czech Republic.

Before you conclude your road trip in the Czech Republic, drop by another restaurant for a last chance at a memorable dining experience in Brno.

If you're in the mood for something new, try Valoria, another premier location with a delectable menu.

You’ll then say farewell to Brno. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in the Czech Republic!

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How it works

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Get instant confirmation
Shortly after booking, you’ll receive your full itinerary, including schedules, locations, and everything you need for a stress-free trip.
Personalize your itinerary
Each package includes a professionally crafted itinerary you can tailor to your travel style. A dedicated travel expert will make sure every detail fits your needs perfectly.
Easily make changes
Need to update plans? No problem. Whether before your trip or mid-journey, we’re just seconds away to help with quick adjustments.
Enjoy seamless planning
With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.
Explore with confidence
From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.
Secure your spot
Confirm your package instantly and lock in the best rate with secure payment and guaranteed availability.
Get instant confirmation
Shortly after booking, you’ll receive your full itinerary, including schedules, locations, and everything you need for a stress-free trip.
Personalize your itinerary
Each package includes a professionally crafted itinerary you can tailor to your travel style. A dedicated travel expert will make sure every detail fits your needs perfectly.
Easily make changes
Need to update plans? No problem. Whether before your trip or mid-journey, we’re just seconds away to help with quick adjustments.
Enjoy seamless planning
With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.
Explore with confidence
From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.

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Your trip is protected, personalized, and priced right. No surprises, no stress.

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