4-Day the Czech Republic Self-Drive Road Trip With Itinerary from Brno to Prague

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Photo of building in Denis Gardens in the center of Brno city, Czech Republic.
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Explore the best of the Czech Republic on a remarkable 4-day road trip! Combine exploration with relaxation on a self-drive tour featuring Brno, Telč, Prague, Český Krumlov, and Třeboň.

This perfectly planned road trip itinerary takes you through some of the best places to see in the Czech Republic. You will spend 2 nights in Brno and 1 night in Prague. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in the Czech Republic. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have you covered.

Upon arriving in Brno, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover the Czech Republic on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in the Czech Republic. Charles Bridge and Prague Astronomical Clock are just a couple of the bucket-list attractions that await your discovery. Marvel at the remarkable Špilberk Castle, learn more about the unique Náměstí Svobody, and immerse yourself in the vibrant atmosphere of The Castle Garden.

As you hit the open road and drive through Brno, Telč, Prague, Český Krumlov, and Třeboň, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of the Czech Republic. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in the Czech Republic.

Throughout your road trip in the Czech Republic, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in the Czech Republic.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodations, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in the Czech Republic fill up quickly, so book your spot early. Select a date and start planning your road trip in the Czech Republic today!

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Driver’s age is 30 - 65
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Pick-up: 10:00
Drop-off: 10:00

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Day 1

Day 1

  • Brno - Arrival day
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  • Špilberk Castle
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Welcome to Brno, the perfect starting point for your road trip in the Czech Republic! Pick up your rental car and let the adventure begin. You will spend 1 night discovering what to see in Brno before embarking on the next leg of your journey.

Brno is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out Špilberk Castle, or just taking a stroll in the city center. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

When you're ready for some downtime, make your way to your chosen hotel. Check-in typically starts between 2 and 4 PM in Brno. Make yourself at home and unwind before heading out again.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Brno, it's often a good idea to reserve a table in advance.

Enjoy a delicious meal at U Štíra, a top-rated dining destination in Brno. If you're in the mood to try something new, consider Bistro Franz, another top spot with a mouthwatering menu. You might also want to secure a reservation at Noem Arch Restaurant. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Brno this evening.

Continue your evening by exploring the vibrant nightlife scene at Bar Naproti, a prime destination for a thrilling night out. Also, don’t forget to check out Super Panda Circus, a bar that offers unique local touches. Likewise, Výčep Na Stojáka provides an excellent alternative for a fun evening.

Raise a toast to the start of your 4-day road trip in the Czech Republic!

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Day 2

Day 2

  • Brno
  • Prague
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Drive 280 km, 3 hours 55 min

  • Villa Tugendhat
  • Telč château
  • Charles Bridge
  • Prague Astronomical Clock
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On day 2 of your exciting self-drive vacation in the Czech Republic, you’ll soak in the magnificence of 3 destinations, including Brno, Telč, and Prague. When you’re not sightseeing, take time to relax at your chosen hotel in Prague, where you’ll be staying for 1 night.

One of the most up-and-coming attractions included on the itinerary is Villa Tugendhat. This picture-perfect museum will help you start your sightseeing on top. Then, take a leisurely stroll to Telč Château and learn what makes this awe-inspiring castle unique.

Throughout the day, make sure to take breaks to appreciate the surroundings. Next up, visit the iconic Charles Bridge. After exploring the historical landmark, head to Prague Astronomical Clock. This top-rated historical landmark is a highlight in Brno.

When you’re done exploring for the day, you’ll drive to your hotel in Prague. Check in and relax before you head out to tour the city.

Indulge in a memorable dining experience at one of Prague's most popular restaurants, and connect with friendly locals for a true cultural experience.

Make sure to reserve a table at U Tellerů, an iconic dining spot in Prague. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Restaurace U Bansethů, a popular restaurant in Prague. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of Eska Restaurant and Bakery, a hidden gem nestled in Prague. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

Cap off your culinary experience with a visit to some of the most celebrated bars in the area. For instance, Anonymous Shrink's Office stands out as an excellent choice for a post-dinner cocktail. Alternatively, Bar No. 7 - Prague offers an ideal atmosphere to enjoy the pleasures of the night. Kontakt Bar is also a great option that provides a perfect setting for a relaxing evening.

Raise your glass and celebrate another amazing day of your road trip in the Czech Republic!

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Day 3

Day 3

  • Prague
  • Brno
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Drive 418 km, 5 hours 41 min

  • Český Krumlov Castle Tower
  • The Castle Garden
  • Třeboň v marcipánu
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On day 3 of your road trip in the Czech Republic, your travel plans include 2 stops at the most scenic, wondrous, and interesting places in the region. Český Krumlov and Třeboň are on today's agenda. In the evening, you’ll end up in Brno, where you will stay for 1 night.

Český Krumlov Castle Tower leaves a lasting impression. This castle is one of the most worthwhile places to visit in Prague. Next, head to The Castle Garden, an often recommended castle, known for its visually striking features.

In between the sights, don’t hesitate to take small detours to explore local stores and eateries. When you’re ready to continue your adventure, head to Třeboň V Marcipánu. This instagrammable museum is a highly recommended experience. Visit these for an interesting touch to your journey.

At the end of the day, you will drive to Brno, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

After a day of adventure, treat yourself to an exquisite dinner at one of Brno's best restaurants.

Make sure to reserve a table at Nok Nok Restaurace Brno, an iconic dining spot in Brno. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Sportovní areál Komec, a popular restaurant in Brno. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of Restaurace L'Eau Vive, a hidden gem nestled in Brno. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

After your meal, keep the night alive at a bar like Jazzový Bar U Kouřícího Králíka, known for its lively atmosphere. Queen Luxury Hookah Club is another top recommendation that provides the perfect setting with well-crafted drinks and a welcoming ambiance. Similarly, Shot Bar offers an excellent atmosphere for those looking to amp up the evening.

Say good night to Brno and look forward to another great day of your road trip in the Czech Republic!

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Day 4

Day 4

  • Brno - Departure day
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  • Náměstí Svobody
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Day 4 of your road trip in the Czech Republic is your departure day. This is your chance to catch a last glimpse of Brno before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

If you're up for some more sightseeing, begin at Náměstí Svobody. This interesting public square is a hotspot among locals.

For a shopping spree in Brno, we recommend the lively Galerie Vaňkovka. Here, you'll find a range of shops you can browse for some souvenir shopping.

Before you conclude your road trip in the Czech Republic, drop by another restaurant for a last chance at a memorable dining experience in Brno.

If you're in the mood to try something new, consider Valoria, another top spot with a mouthwatering menu.

You’ll then say farewell to Brno. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in the Czech Republic!

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How it works

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Shortly after booking, you’ll receive your full itinerary, including schedules, locations, and everything you need for a stress-free trip.
Personalize your itinerary
Each package includes a professionally crafted itinerary you can tailor to your travel style. A dedicated travel expert will make sure every detail fits your needs perfectly.
Easily make changes
Need to update plans? No problem. Whether before your trip or mid-journey, we’re just seconds away to help with quick adjustments.
Enjoy seamless planning
With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.
Explore with confidence
From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.
Secure your spot
Confirm your package instantly and lock in the best rate with secure payment and guaranteed availability.
Get instant confirmation
Shortly after booking, you’ll receive your full itinerary, including schedules, locations, and everything you need for a stress-free trip.
Personalize your itinerary
Each package includes a professionally crafted itinerary you can tailor to your travel style. A dedicated travel expert will make sure every detail fits your needs perfectly.
Easily make changes
Need to update plans? No problem. Whether before your trip or mid-journey, we’re just seconds away to help with quick adjustments.
Enjoy seamless planning
With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.
Explore with confidence
From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.

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Your trip is protected, personalized, and priced right. No surprises, no stress.

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