5-Day the Czech Republic Self-Drive Road Trip With Itinerary from Brno traveling west to Prague

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Photo of building in Denis Gardens in the center of Brno city, Czech Republic.
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Escape the ordinary with this exciting 5-day road trip through the Czech Republic. Explore diverse landscapes, discover lively cities, and prepare for an unforgettable journey!

This perfectly planned road trip itinerary takes you through some of the best places to see in the Czech Republic. You will spend 2 nights in Brno and 2 nights in Prague. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in the Czech Republic. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have you covered.

Upon arriving in Brno, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover the Czech Republic on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in the Czech Republic. Prague Castle and Charles Bridge are just a couple of the bucket-list attractions that await your discovery.

As you hit the open road and drive through Brno, Prague, Karlštejn, and Telč, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of the Czech Republic. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in the Czech Republic.

Throughout your road trip in the Czech Republic, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in the Czech Republic.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodations, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in the Czech Republic fill up quickly, so book your spot early. Select a date and start planning your road trip in the Czech Republic today!

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Driver’s age is 30 - 65
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Pick-up: 10:00
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Day1

Day 1

  • Brno - Arrival day
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  • Špilberk Castle
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Welcome to Brno, the perfect starting point for your road trip in the Czech Republic! Pick up your rental car and let the adventure begin. You will spend 1 night discovering what to see in Brno before embarking on the next leg of your journey.

Brno is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out Špilberk Castle. Taking a stroll in the city center is a great alternative. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

Find your way to your hotel in Brno. We recommend choosing a hotel in a central location for easy exploring. Check-in typically starts between 2 and 4 PM at hotels in the Czech Republic. Settle in and make plans for the evening.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Brno, it's often a good idea to reserve a table in advance.

Treat yourself to a wonderful meal at U Štíra, a top-rated dining spot in Brno. If you're in the mood for something new, try Bistro Franz, another premier location with a delectable menu. You might also want to book a table at Noem Arch Restaurant. Known for its consistently satisfied patrons, it’s a perfect choice to elevate your evening in Brno.

Keep the evening going at Bar Naproti, a great choice for enjoying the after-dinner hours with a drink. You could also go to Super Panda Circus, which offers a similarly pleasant setting and great drinks. Another option is Výčep Na Stojáka, which provides an inviting environment for unwinding after a busy day out.

Raise a toast to the start of your 5-day road trip in the Czech Republic!

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Day2

Day 2

  • Brno
  • Prague
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Drive 212 km, 2 hours 33 min

  • Vyšehrad
  • Charles Bridge
  • Prague Astronomical Clock
  • Old Town Square
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On day 2 of your road trip in the Czech Republic, your travel plans include 1 stop at the most scenic, wondrous, and interesting places in the region. Prague are on today's agenda. In the evening, you’ll end up in Prague, where you will stay for 2 nights.

Vyšehrad is an ideal stop early in the day. This captivating castle is a must-visit in the city. When you’re ready for your next discovery, continue to Charles Bridge, which may be one of the most visually striking places you will experience today.

One of the best things about exploring Brno on a self-guided tour is that you set the pace. There’s plenty of time for detours and discovering hidden gems. When you’re ready for your next stop, make your way to Prague Astronomical Clock, an extraordinary historical landmark in the city. If you’re up for more discoveries, don’t forget to reserve some time for Old Town Square.

After soaking up all the sights on today's itinerary, you'll be ready to head to your accommodation in Prague. Prague offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Prague, it's often a good idea to reserve a table in advance.

Enjoy a lovely dining experience at U Tellerů, a popular restaurant in Prague. This acclaimed establishment has earned the admiration of countless food lovers in the city. Alternatively, experience a taste of Prague at Restaurace U Bansethů, another great place to eat. With a menu designed to impress, it promises a journey of flavors that will leave you captivated. A third option to check out is the top-rated Eska Restaurant and Bakery. It’s yet another ideal choice to enhance your time in Prague tonight.

Cap off your dinner by heading to Anonymous Shrink's Office, ideal for a leisurely evening with a drink in hand. Bar No. 7 - Prague is another bar that offers an enjoyable setting. Similarly, Kontakt Bar is also a popular place to go on a night out, perfect for relaxing and socializing.

As the day draws to a close, take a moment to unwind and prepare for the next exciting chapter of your road trip in the Czech Republic.

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Day3

Day 3

  • Prague
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Drive 76 km, 1 hour 57 min

  • Karlštejn Castle
  • St. Vitus Cathedral
  • Prague Castle
  • Dancing House
  • Powder Tower
  • Malá Strana
  • More

Wake up to day 3 of your road trip in the Czech Republic. On this day, you’ll embark on an exciting expedition discovering the enchanting sights and activities of Karlštejn and Prague. With 1 night to stay in Prague, we encourage you to seize the day and discover the unexplored beauty of the city’s surroundings!

Set aside time today to explore Malá Strana, a standout neighborhood that reflects the essence of the city. While you're there, you'll also be within reach of some of the city's top landmarks, making it easy to maximize your day.

No visit to Prague is complete without Karlštejn Castle. This interesting castle is one of the top attractions in the village. Proceed to St. Vitus Cathedral, another must-visit attraction.

As you wander through the inviting streets of Prague, soak in the lively ambiance and take the opportunity to snap some photos. Next, head to Prague Castle. This iconic castle is a traveler-favorite. Not far away, you’ll find Dancing House, another key site on your sightseeing itinerary. Powder Tower is yet another highly recommended place to visit nearby, offering plenty to discover for curious travelers.

When you’re done exploring the area’s best attractions, you’ll drive back to your accommodation in Prague.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Prague, it's often a good idea to reserve a table in advance.

Make sure to reserve a table at Brasileiro Restaurant, an iconic dining spot in Prague. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Restaurant Meat Beer, a popular restaurant in Prague. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of Restaurace Století, a hidden gem nestled in Prague. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

After enjoying a delightful dinner, why not delve into the vibrant local bar scene? You might want to spend the evening at Bowla Bar, a well-loved spot among locals and tourists. Or, head to The Saints. This bar boasts a welcoming environment that is perfect for winding down. You could also continue your night at Beergeek Bar, another top-rated place in the area.

As the sun sets, rest up and recharge for the next leg of your road trip in the Czech Republic.

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Day4

Day 4

  • Prague
  • Brno
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Drive 285 km, 3 hours 55 min

  • Zámecká Zahrada
  • Telč château
  • Zacharias of Hradec Square
  • Telč House
  • Rozhledna Oslednice
  • More

Dive into day 4 of your remarkable road trip in the Czech Republic. Today you'll explore 1 destination, including Telč. At the end of the day, you’ll unwind at one of the finest accommodations in Brno, where you'll spend 1 night.

Castle Garden makes a great addition to your morning plans. This beloved castle is a visually striking place to see in Prague. Continue your discovery at Telč Château, a history-steeped castle with stories to tell.

As you stroll around Prague, take in the distinct atmosphere and learn what makes this town so unique. Maximize your sightseeing with a visit to Zacharias Of Hradec Square. This worthwhile public square offers a stunning encounter with Prague. Next, make your way to Telč to add another highlight to your day. After that, visit Observation Tower Oslednice, an increasingly popular observation deck that’s sure to impress. Whether you decide to get entrance tickets for all attractions or you prefer admiring from a distance, amazing experiences await on this day in Prague.

At the end of the day, you will drive to Brno, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Brno. Enjoy a relaxing evening as you savor delicious local cuisine.

Make sure to reserve a table at Nok Nok Restaurace Brno, an iconic dining spot in Brno. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Sportovní areál Komec, a popular restaurant in Brno. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of Restaurace L'Eau Vive, a hidden gem nestled in Brno. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

Unwind after your meal by stepping into Jazzový Bar U Kouřícího Králíka. This venue is celebrated for its extensive drink selections and cozy vibes. Alternatively, Queen Luxury Hookah Club offers a dynamic and energetic atmosphere for a glass or two. Don’t overlook Shot Bar, another top-rated bar in the area.

Celebrate another amazing day of your road trip adventure in the Czech Republic!

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Day5

Day 5

  • Brno - Departure day
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  • Masarykova Street
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Day 5 of your road trip in the Czech Republic is your departure day. This is your chance to catch a last glimpse of Brno before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

At the top of the list of places to visit today is Masarykova Street, a street that captures the true essence of Brno. Take your time to uncover its best sides and enjoy its proximity to many of the area’s best attractions.

Take advantage of your accommodation's proximity to Brno’s shopping district for some last-minute bargain hunting. Explore local shops for souvenirs to remember your trip or find unique gifts for loved ones.

Before you conclude your road trip in the Czech Republic, drop by another restaurant for a last chance at a memorable dining experience in Brno.

Treat yourself to a delicious dinner at HOTEL INTERNATIONAL BRNO, an excellent option for tonight's dining. Looking for something different? Valoria offers a tantalizing alternative with its diverse menu.

You’ll then say farewell to Brno. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in the Czech Republic!

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Shortly after booking, you’ll receive your full itinerary, including schedules, locations, and everything you need for a stress-free trip.
Personalize your itinerary
Each package includes a professionally crafted itinerary you can tailor to your travel style. A dedicated travel expert will make sure every detail fits your needs perfectly.
Easily make changes
Need to update plans? No problem. Whether before your trip or mid-journey, we’re just seconds away to help with quick adjustments.
Enjoy seamless planning
With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.
Explore with confidence
From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.
Secure your spot
Confirm your package instantly and lock in the best rate with secure payment and guaranteed availability.
Get instant confirmation
Shortly after booking, you’ll receive your full itinerary, including schedules, locations, and everything you need for a stress-free trip.
Personalize your itinerary
Each package includes a professionally crafted itinerary you can tailor to your travel style. A dedicated travel expert will make sure every detail fits your needs perfectly.
Easily make changes
Need to update plans? No problem. Whether before your trip or mid-journey, we’re just seconds away to help with quick adjustments.
Enjoy seamless planning
With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.
Explore with confidence
From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.

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Your trip is protected, personalized, and priced right. No surprises, no stress.

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