5-Day the Czech Republic Self-Drive Road Trip With Itinerary from Prague to Plzeň and surrounding area

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Photo of famous Charles Bridge over the Vltava river in Prague, Czech Republic.
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Explore the best of the Czech Republic on a 5-day road trip! Uncover hidden gems and experience the rich culture firsthand as you journey through Prague, Plzeň, and Karlštejn. This road trip itinerary in the Czech Republic seamlessly combines exploration with relaxation.

This perfectly planned road trip itinerary in the Czech Republic takes you through some of the best places to see in the country. You will spend 3 nights in Prague and 1 night in Plzeň. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in the Czech Republic. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have got you covered.

Upon arriving in Prague, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover the Czech Republic on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in the Czech Republic. Prague Castle and Charles Bridge are just a couple of the bucket-list attractions that await your discovery. Marvel at the remarkable Old Town Square, learn more about the unique St. Vitus Cathedral, and immerse yourself in the vibrant atmosphere of Prague Astronomical Clock.

As you hit the open road and drive through Prague, Plzeň, and Karlštejn, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of the Czech Republic. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in the Czech Republic.

Throughout your road trip in the Czech Republic, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in the Czech Republic.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodation, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in the Czech Republic fill up quickly, so book your spot early. Select a date and start planning your road trip in the Czech Republic today!

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Driver’s age is 30 - 65
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Day 1

Day 1

  • Prague - Arrival day
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  • Franz Kafka - Rotating Head
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Your road trip adventure in the Czech Republic begins as soon as you reach Prague and pick up your car. You’ll stay in Prague for 2 nights and explore the best things to see and do, sample the local cuisine, and choose from a curated selection of the best hotels and places to stay in the city.

Prague is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out Franz Kafka - Rotating Head By David Cerny, or just taking a stroll in the city center. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

Find your way to your hotel in Prague. We recommend choosing a hotel in a central location for easy exploring. Check-in typically starts between 2 and 4 PM at hotels in the Czech Republic. Settle in and make plans for the evening.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Prague, it's often a good idea to reserve a table in advance.

Enjoy a delicious meal at U Tellerů, a highly-rated dining destination in Prague. If you're eager to try something different, consider Restaurace U Bansethů, another top spot with a tantalizing menu. You might also want to secure a reservation at Eska Restaurant and Bakery. With a reputation for consistently satisfying customers, it’s an excellent choice to enhance your stay in Prague this evening.

Continue your evening by exploring the vibrant nightlife scene at Anonymous Shrink's Office, a prime destination for a thrilling night out. Also, don’t forget to check out Bar No. 7 - Prague, a bar that offers unique local touches. Likewise, Kontakt Bar provides an excellent alternative for a fun evening.

Raise a toast to the start of your 5-day road trip in the Czech Republic!

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Day 2

Day 2

  • Prague
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Drive 15 km, 46 min

  • Vyšehrad
  • Dancing House
  • St. Vitus Cathedral
  • Prague Castle
  • Malá Strana
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On day 2 of your road trip, you will have an entire day to explore Prague. You’ll stay in Prague for 1 night and discover all the best things to see and do in the area.

Make sure to visit Malá Strana, a popular neighborhood in Prague. Spend some time wandering around the area and soak in its distinctive charm. You’ll also discover that several of the city’s must-see attractions are just around the corner.

Today’s itinerary in Prague covers several incredible sights, including a castle, an art installation, and a church. Start your adventure at Vyšehrad. This well-known castle is a place that is appreciated by travelers and locals alike. Next, immerse yourself in the awe-inspiring wonders of Dancing House, a must-see art installation in the city.

Consider stopping for a small bite to eat or a drink at a local eatery to keep your energy going. When you’re ready, continue your discovery with a visit to St. Vitus Cathedral. This impressive church offers an enriching experience. For a change of pace, head to Prague Castle, where you can take in enchanting features. These sights offer a fulfilling end to a perfect day.

Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. The Czech Republic is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.

Experience shopping bliss at Prague as you explore Na Příkopě Street. Take a leisurely stroll through unique and shops, where local treasures are waiting to be found. Beyond shopping, Na Příkopě Street offers more options, including unique attractions, key services, and vibrant events.

Indulge in a memorable dining experience at one of Prague's most popular restaurants, and connect with friendly locals for an authentic adventure.

Make sure to reserve a table at Brasileiro Restaurant, an iconic dining spot in Prague. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Restaurant Meat Beer, a popular restaurant in Prague. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of Restaurace Století, a hidden gem nestled in Prague. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

Let the evening flow smoothly from dinner to drinks at Bowla Bar, a top-rated bar in the area. For other recommendations, The Saints provides a perfect setting for rounding out your night with style and great drinks. Likewise, Beergeek Bar offers a memorable night with diverse drink options and excellent service.

As the sun sets on another day of adventure, rest up and recharge for the next leg of your road trip in the Czech Republic.

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Day 3

Day 3

  • Prague
  • Plzeň-City District
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Drive 103 km, 1 hour 34 min

  • Old Town Square
  • Prague Astronomical Clock
  • Prague Zoo
  • More

Experience an unparalleled adventure on day 3 of your road trip in the Czech Republic. This exciting part of your journey invites you to discover the renowned landmarks in 1 vibrant destinations - Prague. After a day filled with exploration and new experiences, you will retreat to the hotel of your choice in Plzeň. You will spend 1 night here for some well-deserved relaxation.

Savor the day by visiting some of the best places to see in Prague, including a public square, a historical landmark, and a zoo. Start your adventure at Old Town Square. This world-famous public square is a must-visit for travelers looking for a unique holiday experience. Make your way to Prague Astronomical Clock located in Prague for another exciting encounter.

Next, immerse yourself in the setting of Prague Zoo. Its visually striking features will captivate you.

When you’re done exploring for the day, you’ll drive to your hotel in Plzeň. Check in and spend some time relaxing before you head out to tour the city.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Plzeň. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Savor the flavors at Raven Pub City, a top pick for dinner tonight. Alternatively, Restaurace & Hotel U Salzmannů beckons with its unique menu offerings. Also, consider Pláž OSTENDE BOLEVÁK. With its consistent customer satisfaction, it’s an excellent option for dining in Plzeň tonight.

Cap off your culinary experience with a visit to some of the most celebrated bars in the area. For instance, Francis - Beer Café stands out as an excellent choice for a post-dinner cocktail. Alternatively, My Friends Bar offers an ideal atmosphere to enjoy the pleasures of the night. Beer Bar Pioneer is also a great option that provides a perfect setting for a relaxing evening.

As the day draws to a close, take a moment to unwind and prepare for the next exciting chapter of your road trip in in the Czech Republic.

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Day 4

Day 4

  • Plzeň-City District
  • Prague
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Drive 117 km, 1 hour 58 min

  • Cathedral of St. Bartholomew
  • Plzeň Zoo
  • Karlštejn Castle
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Embark on another extraordinary experience on day 4 of your road trip in the Czech Republic. Today, you will make 2 stops and experience some of the highlights of Plzeň and Karlštejn. At the end of the day, you will enjoy the comforts of a top-rated hotel in Prague, which will be your home away from home for 1 night.

Today’s route brings family-friendly attractions, breathtaking views, and picturesque spots. The first attraction of today is Cathedral Of St. Bartholomew. This locally appreciated church is a breathtaking place to see in Plzeň. Continue your discovery at Dinopark Plzeň, a mesmerizing zoo with stories to tell.

As you stroll around Plzeň, take in the distinct atmosphere and learn what makes this city so unique. Maximize your sightseeing with a visit to Karlštejn Castle. This well-known castle offers a romantic encounter with Plzeň. Whether you decide to get entrance tickets for all attractions or you prefer admiring from a distance, amazing experiences await on this day in Plzeň.

After soaking up all the sights of today's itinerary, you'll be ready to head in the direction of your accommodation in Prague. Prague offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

As dinnertime approaches, it's time to head out for a bite to eat in Prague. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.

Don’t miss out on dining at BeBop Bar, a top-rated dining destination in Prague. If you're in the mood to try something new, consider Café restaurant Palanda, another top spot with a mouthwatering menu. You might also want to secure a reservation at Restaurace Tiskárna. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Prague this evening.

Cap off your dinner by heading to Uhříněveský Bar, ideal for a leisurely evening with a drink in hand. Boothill Bar is another bar that offers an enjoyable setting. Similarly, Manesova Bar And Books is also a popular place to go on a night out, perfect for relaxing and socializing.

Say good night to Prague and look forward to another great day of your road trip in the Czech Republic!

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Day 5

Day 5

  • Prague - Departure day
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  • Charles Bridge
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Day 5 of your road trip in the Czech Republic is your departure day. This is your chance to catch a last glimpse of Prague before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

If you're up for some more sightseeing, we recommend visiting Charles Bridge, a culturally significant historical landmark before you head out.

Explore local shops for souvenirs to remember your trip or find unique gifts for loved ones.

Before you conclude your road trip in the Czech Republic, drop by another restaurant for a last chance at a memorable dining experience in Prague.

If you're in the mood to try something new, consider U Fleků, another top spot with a mouthwatering menu.

You’ll then say farewell to Prague. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in the Czech Republic!

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Shortly after booking, you’ll receive your full itinerary, including schedules, locations, and everything you need for a stress-free trip.
Personalize your itinerary
Each package includes a professionally crafted itinerary you can tailor to your travel style. A dedicated travel expert will make sure every detail fits your needs perfectly.
Easily make changes
Need to update plans? No problem. Whether before your trip or mid-journey, we’re just seconds away to help with quick adjustments.
Enjoy seamless planning
With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.
Explore with confidence
From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.
Secure your spot
Confirm your package instantly and lock in the best rate with secure payment and guaranteed availability.
Get instant confirmation
Shortly after booking, you’ll receive your full itinerary, including schedules, locations, and everything you need for a stress-free trip.
Personalize your itinerary
Each package includes a professionally crafted itinerary you can tailor to your travel style. A dedicated travel expert will make sure every detail fits your needs perfectly.
Easily make changes
Need to update plans? No problem. Whether before your trip or mid-journey, we’re just seconds away to help with quick adjustments.
Enjoy seamless planning
With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.
Explore with confidence
From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.

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Your trip is protected, personalized, and priced right. No surprises, no stress.

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