5-Day France Self-Drive Road Trip With Itinerary from Lyon traveling south to Avignon

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Photo of summer view over Vieux Lyon, with famous cathedral Fourviere, and Croix Rousse in Lyon, France.
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Explore the best of France on a remarkable 5-day road trip! Combine exploration with relaxation on a self-drive tour featuring Lyon, Annecy, Chamonix Mont Blanc, Grenoble, Avignon, and Arles.

This perfectly planned road trip itinerary takes you through some of the best places to see in France. You will spend 2 nights in Lyon, 1 night in Les Praz de Chamonix, and 1 night in Avignon. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in France. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have you covered.

Upon arriving in Lyon, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover France on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in France. Palais Des Papes and Place Bellecour are just a couple of the bucket-list attractions that await your discovery. Marvel at the remarkable Pont Saint-benezet (le Pont D'avignon), learn more about the unique Arles Amphitheatre, and immerse yourself in the vibrant atmosphere of Compagnie Du Mont Blanc.

As you hit the open road and drive through Lyon, Annecy, Chamonix Mont Blanc, Grenoble, Avignon, and Arles, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of France. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in France.

Throughout your road trip in France, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in France.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodations, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in France fill up quickly, so book your spot early. Select a date and start planning your road trip in France today!

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Driver’s age is 30 - 65
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Pick-up: 10:00
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Day 1

Day 1

  • Lyon - Arrival day
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  • Vieux Lyon
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Say hello to Lyon! Your exciting road trip through France is just about to start. Navigating the top places to see in the region is a breeze with a car. The rental vehicle of your choice will be ready for pickup upon your arrival in the city. You will stay in Lyon for 1 night before you continue your adventure!

Lyon is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out Vieux Lyon, a must-see neighborhood, and taking a stroll in the city center. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

When you're ready for some downtime, make your way to your chosen hotel. Check-in typically starts between 2 and 4 PM in Lyon. Make yourself at home and unwind before heading out again.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Lyon, it's often a good idea to reserve a table in advance.

Dine in style at Nuage café, a top recommendation for dinner tonight. Or, for a change of pace, Café du Rhône boasts a menu that's sure to impress. Also, be sure to check out Agastache Restaurant. Known as a local hotspot, it’s a great choice for tonight in Lyon.

Continue the enjoyment post-dinner at L' Antiquaire, a cherished local gathering spot renowned for its welcoming atmosphere. Similarly, Black Forest Society offers a vibrant space for indulging in well-crafted drinks and engaging conversation. You may also want to check out Pompette. This bar is a favorite among both locals and visitors looking for a delightful evening out filled with laughter and fun.

Raise a toast to the start of your 5-day road trip in France!

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Day 2

Day 2

  • Lyon
  • More

Drive 279 km, 3 hours 48 min

  • Pont des Amours
  • Jardins de l'Europe d'Annecy
  • Lac d'Annecy
  • Le Pas dans le Vide
  • Aiguille du Midi
  • Compagnie du Mont Blanc
  • More

Dive into day 2 of your remarkable road trip in France. Today you'll explore 3 destinations, including Annecy, Bonneville, and Chamonix Mont Blanc. At the end of the day, you’ll unwind at one of the finest accommodations in Les Praz de Chamonix, where you'll spend 1 night.

Your adventure in Lyon is only getting started when you visit Pont Des Amours, a frequently visited local hot spot. Another notable attraction to explore is Jardins De L'europe D'annecy.

After soaking in the highlights of these sights, take some time to wander Lyon's streets and immerse yourself in the local atmosphere. When you're ready to continue your sightseeing adventure, head to Lake Annecy. This serene lake offers a fascinating experience that many visitors find memorable. Le Pas Dans Le Vide is also worth visiting, along with Aiguille Du Midi. These standout landmarks offer unique experiences that add to the day’s enjoyment. End your day at Compagnie Du Mont Blanc. This notable ski resort provides a fitting finale to your sightseeing.

When you’re done exploring for the day, you’ll drive to your hotel in Les Praz de Chamonix. Check in and relax before you head out to tour the hamlet.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Les Praz de Chamonix. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Enjoy a delicious meal at La Crémerie Du Moulin - Restaurant et Pizzeria Chamonix, a top-rated dining destination in Les Praz de Chamonix. If you're in the mood to try something new, consider L'Arveyron, another top spot with a mouthwatering menu. You might also want to secure a reservation at Cremerie La Montagne. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Les Praz de Chamonix this evening.

Celebrate another amazing day of your road trip adventure in France!

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Day 3

Day 3

  • Avignon
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Drive 428 km, 5 hours 54 min

  • Museum of Grenoble
  • Bastille
  • Jardin des Dauphins
  • Remparts d'Avignon
  • More

On day 3 of your road trip in France, your travel plans include 2 stops at the most scenic, wondrous, and interesting places in the region. Grenoble and Avignon are on today's agenda. In the evening, you’ll end up in Avignon, where you will stay for 1 night.

Make a stop at Musée De Grenoble. This locally appreciated museum is a must-visit for travelers looking for a unique holiday experience. Make your way to Fort De La Bastille located in Les Praz de Chamonix for another exciting encounter.

Next, immerse yourself in the setting of Jardin Des Dauphins. Its peaceful features will captivate you. After the park, continue your tour of the city with a visit to Remparts D'avignon. Visitors usually appreciate the standout features of this historical landmark.

After soaking up all the sights on today's itinerary, you'll be ready to head to your accommodation in Avignon. Avignon offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Avignon. Enjoy a relaxing evening as you savor delicious local cuisine.

Make sure to reserve a table at Restaurant Pollen, an iconic dining spot in Avignon. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Chez Bodus Le Garçon Boucher, a popular restaurant in Avignon. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of La Cuisine de Papa, a hidden gem nestled in Avignon. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

Continue the enjoyment post-dinner at Le 17 Place Aux Vins Avignon • Bar À Vin / Caviste, a cherished local gathering spot renowned for its welcoming atmosphere. Similarly, Barberousse Avignon offers a vibrant space for indulging in well-crafted drinks and engaging conversation. You may also want to check out The Red Sky. This bar is a favorite among both locals and visitors looking for a delightful evening out filled with laughter and fun.

Relax and recharge in preparation for another adventurous day in France!

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Day 4

Day 4

  • Avignon
  • Lyon
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Drive 321 km, 3 hours 57 min

  • Palais des Papes
  • Jardin des doms
  • Pont d'Avignon
  • Fondation Vincent van Gogh Arles
  • Arles Amphitheatre
  • More

Experience an unparalleled adventure on day 4 of your road trip in France. This exciting part of your journey invites you to discover the renowned landmarks in 2 places, which are Avignon and Arles. At the end of the day, you will retreat to the hotel of your choice in Lyon, where will spend 1 night.

Enjoy all that Palais Des Papes has to offer. This is a notable palace you should not miss. Another must-see is Jardin Des Doms, an underrated park in Avignon.

When you’re ready for the next sight, head to Pont Saint-benezet (le Pont D'avignon). From there, take a leisurely stroll to Fondation Vincent Van Gogh Arles, another of the city’s locally appreciated attractions. We recommend continuing your self-guided tour at Arles Amphitheatre, a breathtaking place of interest in the city.

At the end of the day, you will drive to Lyon, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

Lyon is a place where the culinary landscape is as diverse as its attractions. So before the day ends, treat your palate to a taste of local cuisine at one of the best restaurants in Lyon.

Make sure to reserve a table at Bulle - Restaurant de Fourvière - Guy Lassausaie, an iconic dining spot in Lyon. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Bernachon Chocolats, a popular restaurant in Lyon. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of La Mère Léa, a hidden gem nestled in Lyon. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

Keep the evening going at The James Joyce Pub, a great choice for enjoying the after-dinner hours with a drink. You could also go to Broc'bar, which offers a similarly pleasant setting and great drinks. Another option is La Passagère, which provides an inviting environment for unwinding after a busy day out.

Take some time to reflect on your day and savor another beautiful night in France.

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Day 5

Day 5

  • Lyon - Departure day
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  • Place Bellecour
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Day 5 of your road trip in France is your departure day. This is your chance to catch a last glimpse of Lyon before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

If you're up for some more sightseeing, begin at Place Bellecour. This popular public square is a hotspot among locals.

Take some time to indulge in shopping at Lyon’s popular marketplace, Part-Dieu Mall. Look for keepsakes or souvenirs to remind you of your trip.

Before you conclude your road trip in France, drop by another restaurant for a last chance at a memorable dining experience in Lyon.

Dine in style at Nosch, a top recommendation for dinner tonight. Or, for a change of pace, Auberge des canuts - Bouchon Lyonnais boasts a menu that's sure to impress.

You’ll then say farewell to Lyon. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in France!

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Each package includes a professionally crafted itinerary you can tailor to your travel style. A dedicated travel expert will make sure every detail fits your needs perfectly.
Easily make changes
Need to update plans? No problem. Whether before your trip or mid-journey, we’re just seconds away to help with quick adjustments.
Enjoy seamless planning
With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.
Explore with confidence
From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.
Secure your spot
Confirm your package instantly and lock in the best rate with secure payment and guaranteed availability.
Get instant confirmation
Shortly after booking, you’ll receive your full itinerary, including schedules, locations, and everything you need for a stress-free trip.
Personalize your itinerary
Each package includes a professionally crafted itinerary you can tailor to your travel style. A dedicated travel expert will make sure every detail fits your needs perfectly.
Easily make changes
Need to update plans? No problem. Whether before your trip or mid-journey, we’re just seconds away to help with quick adjustments.
Enjoy seamless planning
With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.
Explore with confidence
From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.

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Your trip is protected, personalized, and priced right. No surprises, no stress.

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