4-Day Greece Self-Drive Road Trip With Itinerary from Ioannina to Thessaloniki

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Photo of Plakidas Bridge in Ioannina in Greece by DanaTentis
Photo of Ioannina lake Pamvotida in Epirus Region, Greece.
4-Day Greece Self-Drive Road Trip With Itinerary from Ioannina to Thessaloniki
4-Day Greece Self-Drive Road Trip With Itinerary from Ioannina to Thessaloniki
4-Day Greece Self-Drive Road Trip With Itinerary from Ioannina to Thessaloniki
4-Day Greece Self-Drive Road Trip With Itinerary from Ioannina to Thessaloniki
4-Day Greece Self-Drive Road Trip With Itinerary from Ioannina to Thessaloniki
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Explore the best of Greece on a remarkable 4-day road trip! Combine exploration with relaxation on a self-drive tour featuring Ioannina, Perama, Thessaloniki, Kastraki, and Kalambaka.

This perfectly planned road trip itinerary takes you through some of the best places to see in Greece. You will spend 2 nights in Ioannina and 1 night in Thessaloniki. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Greece. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have you covered.

Upon arriving in Ioannina, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Greece on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Greece. White Tower Of Thessaloniki and Aristotelous Square are just a couple of the bucket-list attractions that await your discovery.

As you hit the open road and drive through Ioannina, Perama, Thessaloniki, Kastraki, and Kalambaka, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Greece. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Greece.

Throughout your road trip in Greece, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Greece.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodations, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in Greece fill up quickly, so book your spot early. Select a date and start planning your road trip in Greece today!

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Driver’s age is 30 - 65
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Pick-up: 10:00
Drop-off: 10:00

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Day1

Day 1

  • Ioannina - Arrival day
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  • Ioannina Castle
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Say hello to Ioannina! Your exciting road trip through Greece is just about to start. Navigating the top places to see in the region is a breeze with a car. The rental vehicle of your choice will be ready for pickup upon your arrival in the city. You will stay in Ioannina for 1 night before you continue your adventure!

Ioannina is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out Ioannina Castle. Taking a stroll in the city center is a great alternative. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

As afternoon approaches, head to your chosen hotel in Ioannina. Check-in typically starts around 2 to 4 PM at hotels in Greece. We recommend staying at a central location for easy access to key areas in the city.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Ioannina, it's often a good idea to reserve a table in advance.

Enjoy a delicious meal at To Dodeka Cafe Bar, a highly-rated dining destination in Ioannina. If you're eager to try something different, consider Mustagogia, another top spot with a tantalizing menu. You might also want to secure a reservation at Accademia Del Panino. With a reputation for consistently satisfying customers, it’s an excellent choice to enhance your stay in Ioannina this evening.

Continue the enjoyment post-dinner at ⚜ V E D E M A ⚜, a cherished local gathering spot renowned for its welcoming atmosphere. Similarly, Hogwarts Tales And Spirits offers a vibrant space for indulging in well-crafted drinks and engaging conversation. You may also want to check out Chevalier. This bar is a favorite among both locals and visitors looking for a delightful evening out filled with laughter and fun.

Raise a toast to the start of your 4-day road trip in Greece!

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Day2

Day 2

  • Ioannina
  • Perama
  • Thessaloniki
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Drive 263 km, 3 hours 41 min

  • Cave of Perama
  • White Tower of Thessaloniki
  • Arch of Galerius
  • Aristotelous Square
  • More

On day 2 of your road trip in Greece, your travel plans include 2 stops at the most scenic, wondrous, and interesting places in the region. Perama and Thessaloniki are on today's agenda. In the evening, you’ll end up in Thessaloniki, where you will stay for 1 night.

As you explore Perama’s charming streets, take in the lively atmosphere and get to know the character of the town.

When you’ve had your share of Ioannina, prepare for your next destination. Admire the views and listen to some good music as you drive in the direction of Perama. Your travel time is around 10 min.

Spend your afternoon discovering Cave Of Perama, an intriguing cave known for its instagrammable features.

Once you're ready to continue your road trip, it's time to buckle up and drive, eagerly anticipating your arrival in Thessaloniki. This drive usually takes around 2 hours 50 min, without any stops or traffic disruptions.

Our first attraction recommendation in Thessaloniki is White Tower Of Thessaloniki, an impressive monument that draws attention for its picture-perfect features. Spend some time soaking in the atmosphere before continuing to Arch Of Galerius And Rotunda, a symbolic monument that stands out in the town.

Time flies when you're having fun! But don't forget to stop for a bit to eat and drink between your adventures. When you're rested and recharged, head to Aristotelous Square, an interesting public square that offers a unique experience.

After soaking up all the sights on today's itinerary, you'll be ready to head to your accommodation in Thessaloniki. Thessaloniki offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Thessaloniki. Enjoy a relaxing evening as you savor delicious local cuisine.

Have a fantastic dining experience at Kitchen Bar, a highly recommended choice for tonight's dinner. If you're looking to mix things up, The Greek offers an enticing alternative with its varied menu. Additionally, Phanós is worth considering. Renowned for satisfying diners, it’s an ideal option for tonight in Thessaloniki.

Unwind after your meal by stepping into Beetle Bar. This venue is celebrated for its extensive drink selections and cozy vibes. Alternatively, Vogatsikou 3 offers a dynamic and energetic atmosphere for a glass or two. Don’t overlook Souel, another top-rated bar in the area.

As the day draws to a close, take a moment to unwind and prepare for the next exciting chapter of your road trip in Greece.

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Day3

Day 3

  • Thessaloniki
  • Kastraki
  • Meteora
  • Ioannina
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Drive 345 km, 5 hours 4 min

  • The Great Meteoron Holy Monastery of the Transfiguration of the Saviour
  • Monastery of Varlaam
  • Main Observation Deck of Meteora
  • Natural History Museum of Meteora and Mushroom Museum
  • More

Your itinerary for day 3 of your road trip in Greece includes 2 stops and features some of the highlights of Kastraki and Kalambaka. At the end of the day, enjoy the comforts of a top-rated hotel in Ioannina, where you'll spend 1 night.

Embrace the thrill of the open road as you wave goodbye to Thessaloniki and set your GPS to Kastraki. While on the road, immerse yourself in your favorite road trip tunes or sample the sounds from a local radio station. This car ride usually takes around 2 hours 53 min. Upon reaching Kastraki, unwind, observe, and explore. The best things to do, see, and eat are waiting for you.

One of our top recommendations for your sightseeing is Holy Monastery Of The Great Meteoron -transfiguration Of The Saviour. Spend some time admiring the breathtaking features of the monastery before you continue to your next stop. Then, head to Monastery Of Varlaam. This often recommended monastery is a traveler-favorite in the village.

If you're keen to see more, continue to Main Observation Deck Of Meteora. Feed your curiosity by learning something new about the observation deck.

Fasten your seatbelt and make your way to your next stop — Kalambaka, home to many well-known sights in the region. Keep in mind that your travel time from Kastraki to Kalambaka may take around 11 min without traffic disruptions. Upon arrival in Kalambaka, we highly recommend checking out some of the top attractions.

Enjoy sightseeing at your own pace and allow yourself time to explore the beautiful surroundings. Take your self-guided tour to Natural History Museum Of Meteora And Mushroom Museum, a frequently visited museum that everyone visiting Kalambaka should see.

When you’re done exploring for the day, you’ll drive to your hotel in Ioannina. Check in and relax before you head out to tour the city.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Ioannina, it's often a good idea to reserve a table in advance.

Enjoy a delicious meal at Spitaki me thea, a top-rated dining destination in Ioannina. If you're in the mood to try something new, consider Frontzoy Politeia - Frontzu Politia Restaurant, another top spot with a mouthwatering menu. You might also want to secure a reservation at Papi Cafe Bistro. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Ioannina this evening.

Keep the evening going at Scala, a great choice for enjoying the after-dinner hours with a drink. You could also go to Route 66 Bar, which offers a similarly pleasant setting and great drinks. Another option is Palia Agora, which provides an inviting environment for unwinding after a busy day out.

Relax and recharge in preparation for another adventurous day in Greece!

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Day4

Day 4

  • Ioannina - Departure day
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  • Ich Kale Acropolis of Ioannina
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Day 4 of your road trip in Greece is your departure day. This is your chance to catch a last glimpse of Ioannina before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

If you're up for some more sightseeing, we recommend visiting Ic Kale Acropolis Of Ioannina, a standout archeological site before you head out.

Take advantage of your accommodation's proximity to Ioannina’s shopping district for some last-minute bargain hunting. Explore local shops for souvenirs to remember your trip or find unique gifts for loved ones. Discover boutiques offering an array of stylish fashion choices. Take a break with a cup of coffee or tea while savoring the local vibe in a coffee shop.

Before you conclude your road trip in Greece, drop by another restaurant for a last chance at a memorable dining experience in Ioannina.

Treat yourself to a delightful dinner at PRESVEIA Restaurant Meze, highly recommended for tonight's dining. Or, if you're feeling adventurous, why not try Frontzu Politia - Hotel? It's another excellent option with a diverse menu.

You’ll then say farewell to Ioannina. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Greece!

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Each package includes a professionally crafted itinerary you can tailor to your travel style. A dedicated travel expert will make sure every detail fits your needs perfectly.
Easily make changes
Need to update plans? No problem. Whether before your trip or mid-journey, we’re just seconds away to help with quick adjustments.
Enjoy seamless planning
With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.
Explore with confidence
From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.
Secure your spot
Confirm your package instantly and lock in the best rate with secure payment and guaranteed availability.
Get instant confirmation
Shortly after booking, you’ll receive your full itinerary, including schedules, locations, and everything you need for a stress-free trip.
Personalize your itinerary
Each package includes a professionally crafted itinerary you can tailor to your travel style. A dedicated travel expert will make sure every detail fits your needs perfectly.
Easily make changes
Need to update plans? No problem. Whether before your trip or mid-journey, we’re just seconds away to help with quick adjustments.
Enjoy seamless planning
With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.
Explore with confidence
From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.

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Your trip is protected, personalized, and priced right. No surprises, no stress.

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