4-Day Greece Self-Drive Road Trip With Itinerary from Ioannina to Thessaloniki

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Escape the ordinary with this exciting 4-day road trip through Greece. Explore the diverse landscapes, lively cities, and beyond. Pack your bags, hit the road, and prepare for an unforgettable journey!

This perfectly planned road trip itinerary in Greece takes you through some of the best places to see in the country. You will spend 2 nights in Ioannina and 1 night in Thessaloniki. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Greece. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have got you covered.

Upon arriving in Ioannina, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Greece on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Greece. White Tower Of Thessaloniki and Aristotelous Square are just a couple of the bucket-list attractions that await your discovery. Marvel at the remarkable Arch Of Galerius And Rotunda, learn more about the unique Ioannina Castle, and immerse yourself in the vibrant atmosphere of Holy Monastery Of The Great Meteoron -transfiguration Of The Saviour.

As you hit the open road and drive through Ioannina, Perama, Thessaloniki, Kastraki, and Kalambaka, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Greece. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Greece.

Throughout your road trip in Greece, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Greece.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodation, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in Greece fill up quickly, so book your spot early. Select a date and start planning your road trip in Greece today!

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Driver’s age is 30 - 65
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Itinerary summary

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Days
Destination
Attractions
Overnight
Day
City & Overnight
Attractions
Ioannina Castle
Cave of PeramaWhite Tower of ThessalonikiArch of GaleriusAristotelous Square
The Great Meteoron Holy Monastery of the Transfiguration of the SaviourMonastery of VarlaamMain Observation Deck of MeteoraNatural History Museum of Meteora and Mushroom Museum
Ich Kale Acropolis of Ioannina

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Day 1

Day 1

  • Ioannina - Arrival day
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  • Ioannina Castle
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Welcome to Ioannina, the perfect starting point for your road trip in Greece! Pick up your rental car and let the adventure begin. You will spend 1 night immersing yourself in Ioannina's charm before embarking on the next leg of your journey.

Ioannina is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out Ioannina Castle, or just taking a stroll in the city center. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

Make your way to your chosen hotel. Check-in typically starts between 2 and 4 PM in Ioannina. Make yourself at home and enjoy some downtime before heading out again.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Ioannina, it's often a good idea to reserve a table in advance.

Savor the flavors at To Dodeka Cafe Bar, a top pick for dinner tonight. Alternatively, Mustagogia beckons with its unique menu offerings. Also, consider Accademia Del Panino. With its consistent customer satisfaction, it’s an excellent option for dining in Ioannina tonight.

Round off your dining experience by visiting ⚜ V E D E M A ⚜, a prime location for a drink. Alternatively, explore the distinctive characteristics of Hogwarts Tales And Spirits, a bar catering to every mood and preference. Chevalier likewise offers a unique atmosphere, perfect for a memorable night out.

Raise a toast to the start of your 4-day road trip in Greece!

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Day 2

Day 2

  • Ioannina
  • Thessaloniki
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Drive 263 km, 3 hours 41 min

  • Cave of Perama
  • White Tower of Thessaloniki
  • Arch of Galerius
  • Aristotelous Square
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On day 2 of your road trip in Greece, you will get a true taste of the freedom a self-drive vacation in Europe entails. Today’s travel plans include stops at the most scenic, wondrous, and interesting places in Perama and Thessaloniki. In the evening, you’ll end up in Thessaloniki, where you will stay for 1 night.

Today’s itinerary in Ioannina covers several incredible sights, including a cave, a monument, and a public square. Start your adventure at Cave Of Perama. This worthwhile cave is a place that is appreciated by travelers and locals alike. Next, immerse yourself in the breathtaking wonders of White Tower Of Thessaloniki, a must-see monument in the town.

Consider stopping for a small bite to eat or a drink at a local eatery to keep your energy going. When you’re ready, continue your discovery with a visit to Arch Of Galerius And Rotunda. This notable monument offers an enriching experience. For a change of pace, head to Aristotelous Square, where you can take in awe-inspiring features. These sights offer a fulfilling end to a perfect day.

At the end of the day, you will drive to Thessaloniki, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

Indulge in a memorable dining experience at one of Thessaloniki's most popular restaurants, and connect with friendly locals for an authentic adventure.

Treat yourself to a delightful dinner at Kitchen Bar, highly recommended for tonight's dining. Or, if you're feeling adventurous, why not try The Greek? It's another excellent option with a diverse menu. Consider reserving a table at Phanós as well. Known for its consistent customer satisfaction, it’s an ideal pick for tonight in Thessaloniki.

After savoring a delicious meal, step into the vibrant nightlife at Beetle Bar, where the evening is just getting started. In the same way, Vogatsikou 3 offers a unique charm perfect for experiencing the local bar scene in Thessaloniki. Souel is another top-recommended bar that is sure to get you into the mood for some dancing and celebrating.

Head back to your accommodation in Thessaloniki and get some rest in preparation for another magical day of your road trip in Greece!

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Day 3

Day 3

  • Thessaloniki
  • Ioannina
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Drive 345 km, 5 hours 4 min

  • The Great Meteoron Holy Monastery of the Transfiguration of the Saviour
  • Monastery of Varlaam
  • Main Observation Deck of Meteora
  • Natural History Museum of Meteora and Mushroom Museum
  • More

Embark on another extraordinary experience on day 3 of your road trip in Greece. Today, you will make 2 stops and experience some of the highlights of Kastraki and Kalambaka. At the end of the day, you will enjoy the comforts of a top-rated hotel in Ioannina, which will be your home away from home for 1 night.

Enjoy the perfect balance of relaxation and exploration in Thessaloniki today. One of the most increasingly popular attractions included on the itinerary is Holy Monastery Of The Great Meteoron -transfiguration Of The Saviour. This stunning monastery will help you start your sightseeing on top. Then, take a leisurely stroll to Monastery Of Varlaam and learn what makes this breathtaking monastery unique.

Throughout the day, make sure to take breaks to appreciate the surroundings. Next up, visit the increasingly popular Main Observation Deck Of Meteora. After exploring the observation deck, head to Natural History Museum Of Meteora And Mushroom Museum. This worthwhile museum is a highlight in Thessaloniki.

When you’re done exploring for the day, you’ll drive to your hotel in Ioannina. Check in and spend some time relaxing before you head out to tour the city.

As dinnertime approaches, it's time to head out for a bite to eat in Ioannina. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.

Make sure to reserve a table at Spitaki me thea, an iconic dining spot in Ioannina. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Frontzoy Politeia - Frontzu Politia Restaurant, a popular restaurant in Ioannina. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of Papi Cafe Bistro, a hidden gem nestled in Ioannina. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

Continue your lively evening at Scala, a perfect place for winding down or revving up the night, depending on which mood you’re in. Route 66 Bar is another excellent bar that offers a great selection of drinks to suit any mood. If you prefer to go somewhere else, Palia Agora ensures a night out tailored to your taste.

Get a good night's sleep and look forward to another great day on the road in Greece!

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Day 4

Day 4

  • Ioannina - Departure day
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  • Ich Kale Acropolis of Ioannina
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Day 4 of your road trip in Greece is your departure day. This is your chance to catch a last glimpse of Ioannina before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

If you're up for some more sightseeing, we recommend visiting Ic Kale Acropolis Of Ioannina, a historic archeological site before you head out.

Make the most of your final day in Greece by visiting Ioannina’s iconic markets and shopping establishments in the buzzing Epirus Street. Secure the perfect souvenirs for your family and friends back home or buy yourself a remembrance of your amazing experience in Greece. You can also browse through boutiques for stylish fashion choices. Savor your final moments in Greece at a cozy cafe while relaxing with a cup of coffee or tea.

Before you conclude your road trip in Greece, drop by another restaurant for a last chance at a memorable dining experience in Ioannina.

You’ll then say farewell to Ioannina. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Greece!

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