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Road trips in Greece

4-Day Greece Self-Drive Road Trip With Itinerary from Ioannina traveling south to Patras

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Photo of Ioannina lake Pamvotida in Epirus Region, Greece.

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Explore the best of Greece on a 4-day road trip! Uncover hidden gems and experience the rich culture firsthand as you journey through Ioannina, Perama, Neo Bizani, Patras, Antirio, and Mesolongi. This road trip itinerary in Greece seamlessly combines exploration with relaxation.

This perfectly planned road trip itinerary in Greece takes you through some of the best places to see in the country. You will spend 2 nights in Ioannina and 1 night in Patras. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Greece. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have got you covered.

Upon arriving in Ioannina, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Greece on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Greece. Ioannina Castle and Moyseio Ellinikis Istorias Payloy Vrelli are just a couple of the bucket-list attractions that await your discovery. Marvel at the remarkable Cave Of Perama, learn more about the unique Charilaos Trikoupis Rio - Antirrio Bridge, and immerse yourself in the vibrant atmosphere of Holy Church Of Saint Andrew.

As you hit the open road and drive through Ioannina, Perama, Neo Bizani, Patras, Antirio, and Mesolongi, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Greece. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Greece.

Throughout your road trip in Greece, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Greece.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodation, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in Greece fill up quickly, so book your spot early. Select a date and start planning your road trip in Greece today!

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Day 1

Ioannina - Arrival day
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Ioannina Castle
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Your road trip adventure in Greece begins as soon as you reach Ioannina and pick up your car. You’ll stay in Ioannina for 1 night and explore the best things to see and do, sample the local cuisine, and choose from a curated selection of the best hotels and places to stay in the city.

Ioannina is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out Ioannina Castle, or just taking a stroll in the city center. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

Make your way to your chosen hotel. Check-in typically starts between 2 and 4 PM in Ioannina. Make yourself at home and enjoy some downtime before heading out again.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Ioannina, it's often a good idea to reserve a table in advance.

Enjoy a delicious meal at To Dodeka Cafe Bar, a highly-rated dining destination in Ioannina. If you're eager to try something different, consider Mustagogia, another top spot with a tantalizing menu. You might also want to secure a reservation at Accademia Del Panino. With a reputation for consistently satisfying customers, it’s an excellent choice to enhance your stay in Ioannina this evening.

Continue your evening by exploring the vibrant nightlife scene at ⚜ V E D E M A ⚜, a prime destination for a thrilling night out. Also, don’t forget to check out Hogwarts Tales And Spirits, a bar that offers unique local touches. Likewise, Chevalier provides an excellent alternative for a fun evening.

Raise a toast to the start of your 4-day road trip in Greece!

Day 2

Ioannina
Patras
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Drive 230 km, 3 hours 9 min

Cave of Perama
Museum "Arslan Pasha"
Ich Kale Acropolis of Ioannina
Silversmithing Museum
Vrellis Greek History Museum (Wax Museum)
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Embark on another extraordinary experience on day 2 of your road trip in Greece. Today, you will make 3 stops and experience some of the highlights of Perama, Ioannina, and Neo Bizani. At the end of the day, you will enjoy the comforts of a top-rated hotel in Patras, which will be your home away from home for 1 night.

Today's adventure in Ioannina promises more breathtaking discoveries and enriching experiences! Begin at Cave Of Perama. This majestic cave is a highlight of any visit in the town. Next, head over to Ic Kale Acropolis Of Ioannina, one of the town’s most up-and-coming attractions, known for its breathtaking features.

If you’re looking for more, spend time soaking in the atmosphere of Silversmithing Museum Of Ioannina. This heritage-rich museum is frequented by locals and tourists alike. To complete your memorable day, make sure to visit Moyseio Ellinikis Istorias Payloy Vrelli, an intriguing museum, and take a stroll around the area.

When you’re done exploring for the day, you’ll drive to your hotel in Patras. Check in and spend some time relaxing before you head out to tour the city.

After a day of adventure, treat yourself to an exquisite dinner at one of Patras's best restaurants.

Treat yourself to a delicious dinner at Tag, an excellent option for tonight's dining. Looking for something different? Bianco offers a tantalizing alternative with its diverse menu. And don’t miss Carousello. With its reputation for pleasing customers, it’s a fantastic choice for tonight in Patras.

Round off your dining experience by visiting Sofita, a prime location for a drink. Alternatively, explore the distinctive characteristics of Charama Therino, a bar catering to every mood and preference. Notos likewise offers a unique atmosphere, perfect for a memorable night out.

Get a good night's sleep and look forward to another great day on the road in Greece!

Day 3

Patras
Ioannina
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Drive 228 km, 3 hours 5 min

King George Ι Square (Patras)
Church of Agios Andreas
Patras' South Park - Notio Parko Patras
Rion-Antirion Bridge
Garden of Heroes
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Experience an unparalleled adventure on day 3 of your road trip in Greece. This exciting part of your journey invites you to discover the renowned landmarks in 3 vibrant destinations - Patras, Antirio, and Mesolongi. After a day filled with exploration and new experiences, you will retreat to the hotel of your choice in Ioannina. You will spend 1 night here for some well-deserved relaxation.

Get ready for an exciting day in Patras. Today’s sightseeing agenda includes a public square, a church, a park, a monument, a cemetery and much more! Begin your adventure at King George I Square (patras). This is a curiosity-inducing public square you should not miss. Another must-see is Holy Church Of Saint Andrew, an underrated church in Patras.

When you’re ready for the next sight, head to Patras' South Park - Notio Parko Patras. From there, take a leisurely stroll to Charilaos Trikoupis Rio - Antirrio Bridge, another of the city’s beloved attractions. We recommend continuing your self-guided tour at Garden Of Heroes, a picture-perfect place of interest in the city.

After soaking up all the sights of today's itinerary, you'll be ready to head in the direction of your accommodation in Ioannina. Ioannina offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Ioannina. Enjoy a relaxing evening as you savor delicious local cuisine and reflect on the day's adventures.

Enjoy a delicious meal at Spitaki me thea, a top-rated dining destination in Ioannina. If you're in the mood to try something new, consider Frontzoy Politeia - Frontzu Politia Restaurant, another top spot with a mouthwatering menu. You might also want to secure a reservation at Papi Cafe Bistro. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Ioannina this evening.

Cap off your culinary experience with a visit to some of the most celebrated bars in the area. For instance, Scala stands out as an excellent choice for a post-dinner cocktail. Alternatively, Route 66 Bar offers an ideal atmosphere to enjoy the pleasures of the night. Palia Agora is also a great option that provides a perfect setting for a relaxing evening.

As the day draws to a close, take a moment to unwind and prepare for the next exciting chapter of your road trip in in Greece.

Day 4

Ioannina - Departure day
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The Clock Tower of Ioannina
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Day 4 of your road trip in Greece is your departure day. This is your chance to catch a last glimpse of Ioannina before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

If you're up for some more sightseeing, begin at The Clock Tower Of Ioannina. This intriguing monument is a popular place to see in the city.

Explore local shops for souvenirs to remember your trip or find unique gifts for loved ones. Discover boutiques offering an array of stylish fashion choices. Take a break with a cup of coffee or tea while savoring the local vibe in a coffee shop.

Before you conclude your road trip in Greece, drop by another restaurant for a last chance at a memorable dining experience in Ioannina.

Treat yourself to a delicious dinner at PRESVEIA Restaurant Meze, an excellent option for tonight's dining. Looking for something different? Frontzu Politia - Hotel offers a tantalizing alternative with its diverse menu. And don’t miss Equus.

You’ll then say farewell to Ioannina. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Greece!

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Shortly after booking, you’ll receive your full itinerary, including schedules, locations, and everything you need for a stress-free trip.

Personalize your itinerary

Each package includes a professionally crafted itinerary you can tailor to your travel style. A dedicated travel expert will make sure every detail fits your needs perfectly.

Easily make changes

Need to update plans? No problem. Whether before your trip or mid-journey, we’re just seconds away to help with quick adjustments.

Enjoy seamless planning

With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.

Explore with confidence

From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.

Secure your spot

Confirm your package instantly and lock in the best rate with secure payment and guaranteed availability.

Get instant confirmation

Shortly after booking, you’ll receive your full itinerary, including schedules, locations, and everything you need for a stress-free trip.

Personalize your itinerary

Each package includes a professionally crafted itinerary you can tailor to your travel style. A dedicated travel expert will make sure every detail fits your needs perfectly.

Easily make changes

Need to update plans? No problem. Whether before your trip or mid-journey, we’re just seconds away to help with quick adjustments.

Enjoy seamless planning

With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.

Explore with confidence

From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.

We guarantee

Your trip is protected, personalized, and priced right. No surprises, no stress.

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