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Road trips in Greece

4-Day Greece Self-Drive Road Trip With Itinerary from Thessaloniki to Trikala

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Photo of Saint Paul cathedral in Thessaloniki, Greece.

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Experience the freedom of the open road on an unforgettable 4-day road trip in Greece! Embark on a self-drive tour that caters to every traveler, featuring destinations like Thessaloniki, Kastraki, Trikala, Kalambaka, and Metsovo.

This perfectly planned road trip itinerary takes you through some of the best places to see in Greece. You will spend 2 nights in Thessaloniki and 1 night in Trikala. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Greece. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have you covered.

Upon arriving in Thessaloniki, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Greece on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Greece. White Tower Of Thessaloniki and Aristotelous Square are just a couple of the bucket-list attractions that await your discovery.

As you hit the open road and drive through Thessaloniki, Kastraki, Trikala, Kalambaka, and Metsovo, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Greece. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Greece.

Throughout your road trip in Greece, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Greece.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodations, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in Greece fill up quickly, so book your spot early. Select a date and start planning your road trip in Greece today!

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Driver’s age is 30 - 65

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Day1

Day 1

Thessaloniki - Arrival day
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Ladadika
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Welcome to Thessaloniki, the perfect starting point for your road trip in Greece! Pick up your rental car and let the adventure begin. You will spend 1 night discovering what to see in Thessaloniki before embarking on the next leg of your journey.

Thessaloniki is a beautiful city with plenty to discover. Taking a stroll in the city center is a great alternative. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

When you're ready for some downtime, make your way to your chosen hotel. Check-in typically starts between 2 and 4 PM in Thessaloniki. Make yourself at home and unwind before heading out again.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Thessaloniki, it's often a good idea to reserve a table in advance.

Enjoy a lovely dining experience at Kitchen Bar, a popular restaurant in Thessaloniki. This acclaimed establishment has earned the admiration of countless food lovers in the city. Alternatively, experience a taste of Thessaloniki at The Greek, another great place to eat. With a menu designed to impress, it promises a journey of flavors that will leave you captivated. A third option to check out is the top-rated Phanós. It’s yet another ideal choice to enhance your time in Thessaloniki tonight.

After enjoying a fulfilling meal, continue your evening at Beetle Bar, ideal for those looking to unwind with a drink in a comfortable setting. Alternatively, Vogatsikou 3 offers a welcoming atmosphere for easing into the nightlife. Similarly, Souel provides an excellent environment for a relaxed and enjoyable evening.

Raise a toast to the start of your 4-day road trip in Greece!

Day2

Day 2

Thessaloniki
Trikala
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Drive 258 km, 4 hours

Aristotelous Square
Agias Sofias Square
White Tower of Thessaloniki
Meteora
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On day 2 of your exciting self-drive vacation in Greece, you’ll soak in the magnificence of 2 destinations, including Thessaloniki and Kastraki. When you’re not sightseeing, take time to relax at your chosen hotel in Trikala, where you’ll be staying for 1 night.

Catch Aristotelous Square before the crowds roll in. This romantic public square is sure to ignite your curiosity. Next, dive into the photogenic features of Agias Sofias Square, a must-visit public square in the city.

In between sights, stop by local stores, picturesque photo spots, and small eateries. When you’re ready for your next attraction, proceed to White Tower Of Thessaloniki, a widely recognized monument. For a change of scene, check out Meteora, known for its enchanting features.

When you’re done exploring for the day, you’ll drive to your hotel in Trikala. Check in and relax before you head out to tour the city.

Indulge in a memorable dining experience at one of Trikala's most popular restaurants, and connect with friendly locals for a true cultural experience.

Don’t miss out on dining at ALVEO, a top-rated dining destination in Trikala. If you're in the mood to try something new, consider Trikala Fortress, another top spot with a mouthwatering menu. You might also want to secure a reservation at Palia Istoria. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Trikala this evening.

Cap off your culinary experience with a visit to some of the most celebrated bars in the area. For instance, Soyita Art Cafe stands out as an excellent choice for a post-dinner cocktail. Alternatively, Factory Café offers an ideal atmosphere to enjoy the pleasures of the night. The Love Shake is also a great option that provides a perfect setting for a relaxing evening.

Take some time to reflect on your day and savor another beautiful night in Greece.

Day3

Day 3

Trikala
Thessaloniki
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Drive 307 km, 4 hours 17 min

Monastery of the Holy Trinity at Meteora
Main Observation Deck of Meteora
The Great Meteoron Holy Monastery of the Transfiguration of the Saviour
Averoff Art Gallery
Metsovo square
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On day 3 of your road trip in Greece, your travel plans include 3 stops at the most scenic, wondrous, and interesting places in the region. Kalambaka, Kastraki, and Metsovo are on today's agenda. In the evening, you’ll end up in Thessaloniki, where you will stay for 1 night.

No visit to Trikala is complete without Monastery Of The Holy Trinity At Meteora. This underrated monastery is one of the top attractions in the town. Proceed to Main Observation Deck Of Meteora, another must-visit attraction.

As you wander through the inviting streets of Trikala, soak in the lively ambiance and take the opportunity to snap some photos. Next, head to Holy Monastery Of The Great Meteoron -transfiguration Of The Saviour. This frequently visited monastery is a traveler-favorite. Not far away, you’ll find Averoff Art Gallery, another key site on your sightseeing itinerary. Metsovo Square is yet another highly recommended place to visit nearby, offering plenty to discover for curious travelers.

After soaking up all the sights on today's itinerary, you'll be ready to head to your accommodation in Thessaloniki. Thessaloniki offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Thessaloniki, it's often a good idea to reserve a table in advance.

Treat yourself to a delightful dinner at Mamalouka, highly recommended for tonight's dining. Or, if you're feeling adventurous, why not try Clochard? It's another excellent option with a diverse menu. Consider reserving a table at Sofi's House Restaurant as well. Known for its consistent customer satisfaction, it’s an ideal pick for tonight in Thessaloniki.

Unwind after your meal by stepping into Castra- All Day Terrace Bar. This venue is celebrated for its extensive drink selections and cozy vibes. Alternatively, Barbaben - Bar/ba/ben offers a dynamic and energetic atmosphere for a glass or two. Don’t overlook Apallou, another top-rated bar in the area.

Head back to your accommodation in Thessaloniki and get some rest to prepare for another magical day of your road trip in Greece.

Day4

Day 4

Thessaloniki - Departure day
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Archaeological Museum of Thessaloniki
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Day 4 of your road trip in Greece is your departure day. This is your chance to catch a last glimpse of Thessaloniki before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

If you're up for some more sightseeing, we recommend visiting Archaeological Museum Of Thessaloniki, a historic museum before you head out.

Make the most of your final day in Greece by visiting Thessaloniki’s iconic markets and shopping establishments in the buzzing Modiano Market. Secure the perfect souvenirs for your family and friends back home or buy yourself a remembrance of your amazing vacation.

Before you conclude your road trip in Greece, drop by another restaurant for a last chance at a memorable dining experience in Thessaloniki.

Have a fantastic dining experience at Enoches Bar, a highly recommended choice for tonight's dinner. If you're looking to mix things up, O Loytros offers an enticing alternative with its varied menu.

You’ll then say farewell to Thessaloniki. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Greece!

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Shortly after booking, you’ll receive your full itinerary, including schedules, locations, and everything you need for a stress-free trip.

Personalize your itinerary

Each package includes a professionally crafted itinerary you can tailor to your travel style. A dedicated travel expert will make sure every detail fits your needs perfectly.

Easily make changes

Need to update plans? No problem. Whether before your trip or mid-journey, we’re just seconds away to help with quick adjustments.

Enjoy seamless planning

With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.

Explore with confidence

From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.

Secure your spot

Confirm your package instantly and lock in the best rate with secure payment and guaranteed availability.

Get instant confirmation

Shortly after booking, you’ll receive your full itinerary, including schedules, locations, and everything you need for a stress-free trip.

Personalize your itinerary

Each package includes a professionally crafted itinerary you can tailor to your travel style. A dedicated travel expert will make sure every detail fits your needs perfectly.

Easily make changes

Need to update plans? No problem. Whether before your trip or mid-journey, we’re just seconds away to help with quick adjustments.

Enjoy seamless planning

With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.

Explore with confidence

From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.

We guarantee

Your trip is protected, personalized, and priced right. No surprises, no stress.

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