4-Day Greece Self-Drive Road Trip With Itinerary from Thessaloniki traveling west to Kalambaka

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Photo of Saint Paul cathedral in Thessaloniki, Greece.
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Explore the best of Greece on a remarkable 4-day road trip! Combine exploration with relaxation on a self-drive tour featuring Thessaloniki, Vergina, Kastraki, Kalambaka, Metsovo, Perama, and Ioannina.

This perfectly planned road trip itinerary takes you through some of the best places to see in Greece. You will spend 2 nights in Thessaloniki and 1 night in Kalambaka. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Greece. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have you covered.

Upon arriving in Thessaloniki, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Greece on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Greece. White Tower Of Thessaloniki and Ioannina Castle are just a couple of the bucket-list attractions that await your discovery.

As you hit the open road and drive through Thessaloniki, Vergina, Kastraki, Kalambaka, Metsovo, Perama, and Ioannina, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Greece. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Greece.

Throughout your road trip in Greece, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Greece.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodations, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in Greece fill up quickly, so book your spot early. Select a date and start planning your road trip in Greece today!

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Driver’s age is 30 - 65
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Pick-up: 10:00
Drop-off: 10:00

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Day1

Day 1

  • Thessaloniki - Arrival day
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  • Ladadika
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Say hello to Thessaloniki! Your exciting road trip through Greece is just about to start. Navigating the top places to see in the region is a breeze with a car. The rental vehicle of your choice will be ready for pickup upon your arrival in the city. You will stay in Thessaloniki for 1 night before you continue your adventure!

Thessaloniki is a beautiful city with plenty to discover. Taking a stroll in the city center is a great alternative. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

When you're ready for some downtime, make your way to your chosen hotel. Check-in typically starts between 2 and 4 PM in Thessaloniki. Make yourself at home and unwind before heading out again.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Thessaloniki, it's often a good idea to reserve a table in advance.

Enjoy a delicious meal at Kitchen Bar, a top-rated dining destination in Thessaloniki. If you're in the mood to try something new, consider The Greek, another top spot with a mouthwatering menu. You might also want to secure a reservation at Phanós. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Thessaloniki this evening.

Cap off your culinary experience with a visit to some of the most celebrated bars in the area. For instance, Beetle Bar stands out as an excellent choice for a post-dinner cocktail. Alternatively, Vogatsikou 3 offers an ideal atmosphere to enjoy the pleasures of the night. Souel is also a great option that provides a perfect setting for a relaxing evening.

Raise a toast to the start of your 4-day road trip in Greece!

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Day2

Day 2

  • Thessaloniki
  • Meteora
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Drive 254 km, 3 hours 40 min

  • Museum of the Royal Tombs at Aigai (Aegae)
  • Monastery of Varlaam
  • Monastery of the Holy Trinity at Meteora
  • Main Observation Deck of Meteora
  • Greek Education Museum
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On day 2 of your exciting self-drive vacation in Greece, you’ll soak in the magnificence of 3 destinations, including Vergina, Kastraki, and Kalambaka. When you’re not sightseeing, take time to relax at your chosen hotel in Kalambaka, where you’ll be staying for 1 night.

Museum Of The Royal Tombs At Aigai (aegae) is must-visit museum and a great option for a daytime tour of the area. Continue your journey to Monastery Of Varlaam, an up-and-coming monastery, located just a leisurely stroll away. Next, head to Monastery Of The Holy Trinity At Meteora, a historic monastery, also available for your discovery today.

Each stop on today’s itinerary promises to leave you with lasting memories and a deeper appreciation for Thessaloniki. When you're ready, let your sightseeing route take you to the increasingly popular Main Observation Deck Of Meteora. If you’re looking for more, Greek Education Museum is also a beloved attraction that is worthwhile a visit.

When you’re done exploring for the day, you’ll drive to your hotel in Kalambaka. Check in and relax before you head out to tour the town.

Kalambaka is a place where the culinary landscape is as diverse as its attractions. So before the day ends, treat your palate to a taste of local cuisine at one of the best restaurants in Kalambaka.

Take some time to reflect on your day and savor another beautiful night in Greece.

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Day3

Day 3

  • Meteora
  • Thessaloniki
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Drive 371 km, 5 hours 20 min

  • Metsovo square
  • Cave of Perama
  • The Clock Tower of Ioannina
  • Ioannina Castle
  • Fethiye Mosque
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On day 3 of your road trip in Greece, your travel plans include 3 stops at the most scenic, wondrous, and interesting places in the region. Metsovo, Perama, and Ioannina are on today's agenda. In the evening, you’ll end up in Thessaloniki, where you will stay for 1 night.

Enjoy all that Metsovo Square has to offer. This is a curiosity-inducing public square you should not miss. Another must-see is Cave Of Perama, a worthwhile cave in Kalambaka.

When you’re ready for the next sight, head to The Clock Tower Of Ioannina. From there, take a leisurely stroll to Ioannina Castle, another of the town’s well-known attractions. We recommend continuing your self-guided tour at Fethiye Mosque, a grand place of interest in the town.

After soaking up all the sights on today's itinerary, you'll be ready to head to your accommodation in Thessaloniki. Thessaloniki offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Thessaloniki, it's often a good idea to reserve a table in advance.

Treat yourself to a wonderful meal at Mamalouka, a top-rated dining spot in Thessaloniki. If you're in the mood for something new, try Clochard, another premier location with a delectable menu. You might also want to book a table at Sofi's House Restaurant. Known for its consistently satisfied patrons, it’s a perfect choice to elevate your evening in Thessaloniki.

Unwind after your meal by stepping into Castra- All Day Terrace Bar. This venue is celebrated for its extensive drink selections and cozy vibes. Alternatively, Barbaben - Bar/ba/ben offers a dynamic and energetic atmosphere for a glass or two. Don’t overlook Apallou, another top-rated bar in the area.

Relax and look forward to more memorable moments to come!

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Day4

Day 4

  • Thessaloniki - Departure day
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  • White Tower of Thessaloniki
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Day 4 of your road trip in Greece is your departure day. This is your chance to catch a last glimpse of Thessaloniki before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

If you're up for some more sightseeing, we recommend visiting White Tower Of Thessaloniki, a breathtaking monument before you head out.

Take some time to indulge in shopping at Thessaloniki’s popular marketplace, Modiano Market. Look for keepsakes or souvenirs to remind you of your trip.

Before you conclude your road trip in Greece, drop by another restaurant for a last chance at a memorable dining experience in Thessaloniki.

You’ll then say farewell to Thessaloniki. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Greece!

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Shortly after booking, you’ll receive your full itinerary, including schedules, locations, and everything you need for a stress-free trip.
Personalize your itinerary
Each package includes a professionally crafted itinerary you can tailor to your travel style. A dedicated travel expert will make sure every detail fits your needs perfectly.
Easily make changes
Need to update plans? No problem. Whether before your trip or mid-journey, we’re just seconds away to help with quick adjustments.
Enjoy seamless planning
With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.
Explore with confidence
From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.
Secure your spot
Confirm your package instantly and lock in the best rate with secure payment and guaranteed availability.
Get instant confirmation
Shortly after booking, you’ll receive your full itinerary, including schedules, locations, and everything you need for a stress-free trip.
Personalize your itinerary
Each package includes a professionally crafted itinerary you can tailor to your travel style. A dedicated travel expert will make sure every detail fits your needs perfectly.
Easily make changes
Need to update plans? No problem. Whether before your trip or mid-journey, we’re just seconds away to help with quick adjustments.
Enjoy seamless planning
With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.
Explore with confidence
From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.

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Your trip is protected, personalized, and priced right. No surprises, no stress.

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