4-Day Greece Self-Drive Road Trip With Itinerary from Thessaloniki traveling west to Kalambaka

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Explore the best of Greece on a 4-day road trip! Uncover hidden gems and experience the rich culture firsthand as you journey through Thessaloniki, Vergina, Kastraki, Kalambaka, Metsovo, Perama, and Ioannina. This road trip itinerary in Greece seamlessly combines exploration with relaxation.

This perfectly planned road trip itinerary in Greece takes you through some of the best places to see in the country. You will spend 2 nights in Thessaloniki and 1 night in Kalambaka. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Greece. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have got you covered.

Upon arriving in Thessaloniki, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Greece on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Greece. White Tower Of Thessaloniki and Ioannina Castle are just a couple of the bucket-list attractions that await your discovery. Marvel at the remarkable Museum Of The Royal Tombs At Aigai (aegae), learn more about the unique Monastery Of Varlaam, and immerse yourself in the vibrant atmosphere of Cave Of Perama.

As you hit the open road and drive through Thessaloniki, Vergina, Kastraki, Kalambaka, Metsovo, Perama, and Ioannina, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Greece. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Greece.

Throughout your road trip in Greece, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Greece.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodation, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in Greece fill up quickly, so book your spot early. Select a date and start planning your road trip in Greece today!

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Itinerary summary

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Days
Destination
Attractions
Overnight
Day
City & Overnight
Attractions
Ladadika
Museum of the Royal Tombs at Aigai (Aegae)Monastery of VarlaamMonastery of the Holy Trinity at MeteoraMain Observation Deck of MeteoraGreek Education Museum
Metsovo squareCave of PeramaThe Clock Tower of IoanninaIoannina CastleFethiye Mosque
White Tower of Thessaloniki

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Day 1

Day 1

  • Thessaloniki - Arrival day
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  • Ladadika
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Your road trip adventure in Greece begins as soon as you reach Thessaloniki and pick up your car. You’ll stay in Thessaloniki for 1 night and explore the best things to see and do, sample the local cuisine, and choose from a curated selection of the best hotels and places to stay in the city.

Thessaloniki is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out Ladadika, a must-see neighborhood, and taking a stroll in the city center. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

As afternoon approaches, head to your chosen hotel in Thessaloniki. Check-in typically starts around 2 to 4 PM at hotels in Greece. We recommend staying at a hotel in a central location for easy access to the best attractions, restaurants, and bars in the city.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Thessaloniki, it's often a good idea to reserve a table in advance.

Enjoy a lovely meal at Kitchen Bar, a top-rated place to have dinner tonight. Alternatively, if your taste buds call for something different, The Greek is another top choice with a popular menu. You could also check for a table at Phanós. As an establishment that gains consistently high praises from customers, it’s an ideal choice in Thessaloniki tonight.

After enjoying a delightful dinner, why not delve into the vibrant local bar scene? You might want to spend the evening at Beetle Bar, a well-loved spot among locals and tourists. Or, head to Vogatsikou 3. This bar boasts a welcoming environment that is perfect for winding down. You could also continue your night at Souel, another top-rated place in the area.

Raise a toast to the start of your 4-day road trip in Greece!

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Day 2

Day 2

  • Thessaloniki
  • Meteora
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Drive 254 km, 3 hours 40 min

  • Museum of the Royal Tombs at Aigai (Aegae)
  • Monastery of Varlaam
  • Monastery of the Holy Trinity at Meteora
  • Main Observation Deck of Meteora
  • Greek Education Museum
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Experience an unparalleled adventure on day 2 of your road trip in Greece. This exciting part of your journey invites you to discover the renowned landmarks in 3 vibrant destinations - Vergina, Kastraki, and Kalambaka. After a day filled with exploration and new experiences, you will retreat to the hotel of your choice in Kalambaka. You will spend 1 night here for some well-deserved relaxation.

Today's adventure in Thessaloniki promises more breathtaking discoveries and enriching experiences! Begin at Museum Of The Royal Tombs At Aigai (aegae). This UNESCO world heritage-designated museum is a highlight of any visit in the village. Then, enjoy Monastery Of Varlaam, another historic attraction that never fails to captivate visitors. Next, head over to Monastery Of The Holy Trinity At Meteora, one of the village’s most underrated attractions, known for its picture-perfect features.

If you’re looking for more, spend time soaking in the atmosphere of Main Observation Deck Of Meteora. This mesmerizing observation deck is frequented by locals and tourists alike. To complete your memorable day, make sure to visit Greek Education Museum, a worthwhile museum, and take a stroll around the area.

When you’re done exploring for the day, you’ll drive to your hotel in Kalambaka. Check in and spend some time relaxing before you head out to tour the town.

After a day of adventure, treat yourself to an exquisite dinner at one of Kalambaka's best restaurants.

As the sun sets on another day of adventure, rest up and recharge for the next leg of your road trip in Greece.

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Day 3

Day 3

  • Meteora
  • Thessaloniki
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Drive 371 km, 5 hours 20 min

  • Metsovo square
  • Cave of Perama
  • The Clock Tower of Ioannina
  • Ioannina Castle
  • Fethiye Mosque
  • More

Dive into day 3 of your remarkable road trip in Greece. Today you will explore Metsovo, Perama, and Ioannina, where you will have the opportunity to experience all the top things to see and do. At the end of the day, you’ll unwind at one of the finest accommodations in Thessaloniki. You’ll stay here for 1 night.

Bring your curiosity for today’s adventure around Kalambaka. Some of the town’s most loved attractions await. Metsovo Square is the perfect place to start. This public square is one of the most underrated places to visit in Kalambaka. Next, head to Cave Of Perama, a frequently visited cave, known for its enchanting features.

In between the sights, don’t hesitate to take small detours to explore local stores and eateries. When you’re ready to continue your adventure, head to The Clock Tower Of Ioannina. This standout monument offers a unique experience that is highly recommended. Meanwhile, Ioannina Castle adds its own distinct charm to your journey. Finish your day with a visit to Fethiye Mosque, a picture-perfect mosque in Kalambaka.

After soaking up all the sights of today's itinerary, you'll be ready to head in the direction of your accommodation in Thessaloniki. Thessaloniki offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Thessaloniki. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Make sure to reserve a table at Mamalouka, an iconic dining spot in Thessaloniki. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Clochard, a popular restaurant in Thessaloniki. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of Sofi's House Restaurant, a hidden gem nestled in Thessaloniki. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

Round off your dining experience by visiting Castra- All Day Terrace Bar, a prime location for a drink. Alternatively, explore the distinctive characteristics of Barbaben - Bar/ba/ben, a bar catering to every mood and preference. Apallou likewise offers a unique atmosphere, perfect for a memorable night out.

Take some time to reflect on your day and savor another beautiful night in Greece.

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Day 4

Day 4

  • Thessaloniki - Departure day
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  • White Tower of Thessaloniki
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Day 4 of your road trip in Greece is your departure day. This is your chance to catch a last glimpse of Thessaloniki before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

If you're up for some more sightseeing, begin at White Tower Of Thessaloniki. This spectacular monument is a popular place to see in the city.

Explore local shops for souvenirs to remember your trip or find unique gifts for loved ones. Discover boutiques offering an array of stylish fashion choices.

Before you conclude your road trip in Greece, drop by another restaurant for a last chance at a memorable dining experience in Thessaloniki.

If you're in the mood to try something new, consider O Loytros, another top spot with a mouthwatering menu.

You’ll then say farewell to Thessaloniki. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Greece!

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