5-Day Greece Self-Drive Road Trip With Itinerary from Thessaloniki to Kalambaka

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Photo of Saint Paul cathedral in Thessaloniki, Greece.
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Explore the best of Greece on a remarkable 5-day road trip! Combine exploration with relaxation on a self-drive tour featuring Thessaloniki, Kastraki, Kalambaka, Dion, and Neos Panteleimonas.

This perfectly planned road trip itinerary takes you through some of the best places to see in Greece. You will spend 3 nights in Thessaloniki and 1 night in Kalambaka. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Greece. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have you covered.

Upon arriving in Thessaloniki, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Greece on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Greece. White Tower Of Thessaloniki and Aristotelous Square are just a couple of the bucket-list attractions that await your discovery.

As you hit the open road and drive through Thessaloniki, Kastraki, Kalambaka, Dion, and Neos Panteleimonas, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Greece. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Greece.

Throughout your road trip in Greece, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Greece.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodations, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in Greece fill up quickly, so book your spot early. Select a date and start planning your road trip in Greece today!

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Driver’s age is 30 - 65
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Pick-up: 10:00
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Day1

Day 1

  • Thessaloniki - Arrival day
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  • Ladadika
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Welcome to Thessaloniki, the perfect starting point for your road trip in Greece! Pick up your rental car and let the adventure begin. You will spend 2 nights discovering what to see in Thessaloniki before embarking on the next leg of your journey.

Thessaloniki is a beautiful city with plenty to discover. Taking a stroll in the city center is a great alternative. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

When you're ready for some downtime, make your way to your chosen hotel. Check-in typically starts between 2 and 4 PM in Thessaloniki. Make yourself at home and unwind before heading out again.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Thessaloniki, it's often a good idea to reserve a table in advance.

Make sure to reserve a table at Kitchen Bar, an iconic dining spot in Thessaloniki. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of The Greek, a popular restaurant in Thessaloniki. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of Phanós, a hidden gem nestled in Thessaloniki. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

Cap off your culinary experience with a visit to some of the most celebrated bars in the area. For instance, Beetle Bar stands out as an excellent choice for a post-dinner cocktail. Alternatively, Vogatsikou 3 offers an ideal atmosphere to enjoy the pleasures of the night. Souel is also a great option that provides a perfect setting for a relaxing evening.

Raise a toast to the start of your 5-day road trip in Greece!

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Day2

Day 2

  • Thessaloniki
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Drive 6 km, 55 min

  • Aristotelous Square
  • Agias Sofias Square
  • Arch of Galerius
  • White Tower of Thessaloniki
  • Archaeological Museum of Thessaloniki
  • Tsimiski Street
  • More

Day 2 of your road trip will take you to the best attractions Thessaloniki has to offer. Cherish the 1 night you have left in the city and use the provided itinerary to discover what to see in Thessaloniki.

Tsimiski Street is a fantastic place you can explore today in Thessaloniki. This street is a testament to the city’s character, and it's easy to spend hours just walking around and admiring the surroundings. Soak in the Thessaloniki-way-of-life and visit all the nearby sights.

Visiting Aristotelous Square is always a good idea. This locally renowned public square is a place that is appreciated by travelers and locals alike. Next, immerse yourself in the photogenic wonders of Agias Sofias Square, a must-see public square in the city.

Consider stopping for a small bite to eat or a drink at a local eatery to keep your energy going. When you’re ready, continue your discovery with a visit to Arch Of Galerius And Rotunda. This captivating monument offers an enriching experience. For a change of pace, head to White Tower Of Thessaloniki, where you can take in breathtaking features. Conclude your self-guided sightseeing tour with a visit to Archaeological Museum Of Thessaloniki These sights offer a fulfilling end to a perfect day.

Don’t forget to check out all the popular tours and experiences you can add to your travel plans in Greece. You can explore and select activities under each day of your itinerary.

For an unforgettable shopping experience, visit Modiano Market, the top shopping destination in Thessaloniki. Browse local shops and stores, each offering delightful surprises. Find unique souvenirs or items to take home. After shopping, explore what Modiano Market has to offer, including attractions, essential services, and vibrant community activities.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Thessaloniki, it's often a good idea to reserve a table in advance.

Dine in style at Mamalouka, a top recommendation for dinner tonight. Or, for a change of pace, Clochard boasts a menu that's sure to impress. Also, be sure to check out Sofi's House Restaurant. Known as a local hotspot, it’s a great choice for tonight in Thessaloniki.

If you’re not ready to end the night just yet, Castra- All Day Terrace Bar offers a perfect venue to relax and savor a drink. Similarly, Barbaben - Bar/ba/ben is well-suited for those looking to unwind in a social setting. Apallou is another excellent spot to enjoy a nightcap after a delightful meal.

Raise your glass and celebrate another amazing day of your road trip in Greece!

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Day3

Day 3

  • Thessaloniki
  • Meteora
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Drive 240 km, 3 hours 33 min

  • The Great Meteoron Holy Monastery of the Transfiguration of the Saviour
  • Monastery of Varlaam
  • Main Observation Deck of Meteora
  • Natural History Museum of Meteora and Mushroom Museum
  • Greek Education Museum
  • More

Your itinerary for day 3 of your road trip in Greece includes 2 stops and features some of the highlights of Kastraki and Kalambaka. At the end of the day, enjoy the comforts of a top-rated hotel in Kalambaka, where you'll spend 1 night.

Make time for Holy Monastery Of The Great Meteoron -transfiguration Of The Saviour, a worthwhile monastery that is worthwhile a visit in the village. Nearby, you’ll find Monastery Of Varlaam, enchanting visitors with its historic appeal. Continue your exploration at Main Observation Deck Of Meteora. This observation deck is one of the village’s most worthwhile spots.

Enjoy the freedom of exploring Thessaloniki at your own pace and find hidden gems along the way. If you want to see more picture-perfect spots, make sure to visit Natural History Museum Of Meteora And Mushroom Museum. After exploring the museum, head to the underrated Greek Education Museum.

At the end of the day, you will drive to Kalambaka, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

Kalambaka is a place where the culinary landscape is as diverse as its attractions. So before the day ends, treat your palate to a taste of local cuisine at one of the best restaurants in Kalambaka.

Celebrate another amazing day of your road trip adventure in Greece!

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Day4

Day 4

  • Meteora
  • Thessaloniki
  • More

Drive 321 km, 4 hours 32 min

  • Archaeological Site of Dion
  • Καταρράκτες Ενιπεα (Μονής Αγίου Διονυσίου)
  • Byzantine Castle of Platamon
  • More

On day 4 of your road trip in Greece, your travel plans include 3 stops at the most scenic, wondrous, and interesting places in the region. Dion, Litochoro, and Neos Panteleimonas are on today's agenda. In the evening, you’ll end up in Thessaloniki, where you will stay for 1 night.

Experience Archaeological Park Of Dion, an up-and-coming archeological site in the village. Then, head to Enipeas Falls and soak in the ambiance of this eye-catching waterfall.

There are many interesting places to see in Kalambaka, and when you are ready for more, go to Platamon Castle. This is one of the village’s most up-and-coming awe-inspiring spots of interest.

After soaking up all the sights on today's itinerary, you'll be ready to head to your accommodation in Thessaloniki. Thessaloniki offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Thessaloniki. Enjoy a relaxing evening as you savor delicious local cuisine.

Enjoy a delicious meal at Enoches Bar, a highly-rated dining destination in Thessaloniki. If you're eager to try something different, consider O Loytros, another top spot with a tantalizing menu. You might also want to secure a reservation at rOOTS. With a reputation for consistently satisfying customers, it’s an excellent choice to enhance your stay in Thessaloniki this evening.

After enjoying a delightful dinner, why not delve into the vibrant local bar scene? You might want to spend the evening at Peiratis Cafe-bar, a well-loved spot among locals and tourists. Or, head to In Rock Cafe Bar. This bar boasts a welcoming environment that is perfect for winding down. You could also continue your night at Tribeca, another top-rated place in the area.

Say good night to Thessaloniki and look forward to another great day of your road trip in Greece!

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Day5

Day 5

  • Thessaloniki - Departure day
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  • The Umbrellas by Zongolopoulos
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Day 5 of your road trip in Greece is your departure day. This is your chance to catch a last glimpse of Thessaloniki before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

If you're up for some more sightseeing, begin at The Umbrellas Sculpture By Zogolopoulos. This captivating art installation is a hotspot among locals.

Take advantage of your accommodation's proximity to Thessaloniki’s shopping district for some last-minute bargain hunting. Explore local shops for souvenirs to remember your trip or find unique gifts for loved ones.

Before you conclude your road trip in Greece, drop by another restaurant for a last chance at a memorable dining experience in Thessaloniki.

Treat yourself to a delicious dinner at Millet, an excellent option for tonight's dining. Looking for something different? Agora Ouzeri offers a tantalizing alternative with its diverse menu.

You’ll then say farewell to Thessaloniki. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Greece!

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Shortly after booking, you’ll receive your full itinerary, including schedules, locations, and everything you need for a stress-free trip.
Personalize your itinerary
Each package includes a professionally crafted itinerary you can tailor to your travel style. A dedicated travel expert will make sure every detail fits your needs perfectly.
Easily make changes
Need to update plans? No problem. Whether before your trip or mid-journey, we’re just seconds away to help with quick adjustments.
Enjoy seamless planning
With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.
Explore with confidence
From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.
Secure your spot
Confirm your package instantly and lock in the best rate with secure payment and guaranteed availability.
Get instant confirmation
Shortly after booking, you’ll receive your full itinerary, including schedules, locations, and everything you need for a stress-free trip.
Personalize your itinerary
Each package includes a professionally crafted itinerary you can tailor to your travel style. A dedicated travel expert will make sure every detail fits your needs perfectly.
Easily make changes
Need to update plans? No problem. Whether before your trip or mid-journey, we’re just seconds away to help with quick adjustments.
Enjoy seamless planning
With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.
Explore with confidence
From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.

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Your trip is protected, personalized, and priced right. No surprises, no stress.

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