5-Day Greece Self-Drive Road Trip With Itinerary from Thessaloniki to Kalambaka

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Photo of Saint Paul cathedral in Thessaloniki, Greece.
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Escape the ordinary with this exciting 5-day road trip through Greece. Explore diverse landscapes, discover lively cities, and prepare for an unforgettable journey!

This perfectly planned road trip itinerary takes you through some of the best places to see in Greece. You will spend 3 nights in Thessaloniki and 1 night in Kalambaka. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Greece. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have you covered.

Upon arriving in Thessaloniki, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Greece on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Greece. White Tower Of Thessaloniki and Aristotelous Square are just a couple of the bucket-list attractions that await your discovery. Marvel at the remarkable The Umbrellas Sculpture By Zogolopoulos, learn more about the unique Arch Of Galerius And Rotunda, and immerse yourself in the vibrant atmosphere of Agias Sofias Square.

As you hit the open road and drive through Thessaloniki, Kastraki, Kalambaka, Dion, and Neos Panteleimonas, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Greece. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Greece.

Throughout your road trip in Greece, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Greece.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodations, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in Greece fill up quickly, so book your spot early. Select a date and start planning your road trip in Greece today!

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Driver’s age is 30 - 65
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Pick-up: 10:00
Drop-off: 10:00

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Day 1

Day 1

  • Thessaloniki - Arrival day
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  • Ladadika
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Your road trip adventure in Greece begins as soon as you reach Thessaloniki and pick up your car. You’ll stay here for 2 nights and explore what to see in Thessaloniki, sample the local cuisine, and choose from a curated selection of the best hotels and places to stay in the city.

Thessaloniki is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out Ladadika, a must-see neighborhood, and taking a stroll in the city center. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

When you're ready for some downtime, make your way to your chosen hotel. Check-in typically starts between 2 and 4 PM in Thessaloniki. Make yourself at home and unwind before heading out again.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Thessaloniki, it's often a good idea to reserve a table in advance.

Have a fantastic dining experience at Kitchen Bar, a highly recommended choice for tonight's dinner. If you're looking to mix things up, The Greek offers an enticing alternative with its varied menu. Additionally, Phanós is worth considering. Renowned for satisfying diners, it’s an ideal option for tonight in Thessaloniki.

Keep the evening going at Beetle Bar, a great choice for enjoying the after-dinner hours with a drink. You could also go to Vogatsikou 3, which offers a similarly pleasant setting and great drinks. Another option is Souel, which provides an inviting environment for unwinding after a busy day out.

Raise a toast to the start of your 5-day road trip in Greece!

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Day 2

Day 2

  • Thessaloniki
  • More

Drive 6 km, 55 min

  • Aristotelous Square
  • Agias Sofias Square
  • Arch of Galerius
  • White Tower of Thessaloniki
  • Archaeological Museum of Thessaloniki
  • Tsimiski Street
  • More

Day 2 of your road trip will take you to the best attractions Thessaloniki has to offer. Cherish the 1 night you have left in the city and use the provided itinerary to discover what to see in Thessaloniki.

Whether you decide to explore Thessaloniki on foot, use public transport, or join a guided tour, there are a few attractions you don’t want to miss. Make sure to visit Tsimiski Street, a popular street in Thessaloniki. Spend some time wandering around the area and soak in its distinctive charm. You’ll also discover that several of the city’s must-see attractions are just around the corner.

Make time for Aristotelous Square, a well-known public square that is worthwhile a visit in the city. Nearby, you’ll find Agias Sofias Square, enchanting visitors with its symbolic appeal. Continue your exploration at Arch Of Galerius And Rotunda. This monument is one of the city’s most popular spots.

Enjoy the freedom of exploring Thessaloniki at your own pace and find hidden gems along the way. If you want to see more picture-perfect spots, make sure to visit White Tower Of Thessaloniki. After exploring the monument, head to the beloved Archaeological Museum Of Thessaloniki.

Don’t forget to check out all the popular tours and experiences you can add to your travel plans in Greece. You can explore and select activities under each day of your itinerary.

For an unforgettable shopping experience, visit Modiano Market, the top shopping destination in Thessaloniki. Browse local shops and stores, each offering delightful surprises. Find unique souvenirs or items to take home. After shopping, explore what Modiano Market has to offer, including attractions, essential services, and vibrant community activities.

After a day of adventure, treat yourself to an exquisite dinner at one of Thessaloniki's best restaurants.

Savor the flavors at Mamalouka, a top pick for dinner tonight. Alternatively, Clochard beckons with its unique menu offerings. Also, consider Sofi's House Restaurant. With its consistent customer satisfaction, it’s an excellent option for dining in Thessaloniki tonight.

Round off your dining experience by visiting Castra- All Day Terrace Bar, a prime location for a drink. Alternatively, explore the distinctive characteristics of Barbaben - Bar/ba/ben, a bar catering to every mood and preference. Apallou likewise offers a unique atmosphere, perfect for a memorable night out.

Head back to your accommodation in Thessaloniki and get some rest to prepare for another magical day of your road trip in Greece.

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Day 3

Day 3

  • Thessaloniki
  • Meteora
  • More

Drive 240 km, 3 hours 33 min

  • The Great Meteoron Holy Monastery of the Transfiguration of the Saviour
  • Monastery of Varlaam
  • Main Observation Deck of Meteora
  • Natural History Museum of Meteora and Mushroom Museum
  • Greek Education Museum
  • More

On day 3 of your road trip in Greece, your travel plans include 2 stops at the most scenic, wondrous, and interesting places in the region. Kastraki and Kalambaka are on today's agenda. In the evening, you’ll end up in Kalambaka, where you will stay for 1 night.

Make a stop at Holy Monastery Of The Great Meteoron -transfiguration Of The Saviour. This intriguing monastery is a must-visit for travelers looking for a unique holiday experience. Make your way to Monastery Of Varlaam located in Thessaloniki for another exciting encounter.

Next, immerse yourself in the setting of Main Observation Deck Of Meteora. Its romantic features will captivate you. After the observation deck, continue your tour of the village with a visit to Natural History Museum Of Meteora And Mushroom Museum. Visitors usually appreciate the eye-catching features of this museum. Next up is Greek Education Museum, a highly recommended museum.

After soaking up all the sights on today's itinerary, you'll be ready to head to your accommodation in Kalambaka. Kalambaka offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

Kalambaka is a place where the culinary landscape is as diverse as its attractions. So before the day ends, treat your palate to a taste of local cuisine at one of the best restaurants in Kalambaka.

Get a good night's sleep and look forward to another great day on the road in Greece!

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Day 4

Day 4

  • Meteora
  • Thessaloniki
  • More

Drive 321 km, 4 hours 32 min

  • Archaeological Site of Dion
  • Καταρράκτες Ενιπεα (Μονής Αγίου Διονυσίου)
  • Byzantine Castle of Platamon
  • More

On day 4 of your exciting self-drive vacation in Greece, you’ll soak in the magnificence of 3 destinations, including Dion, Litochoro, and Neos Panteleimonas. When you’re not sightseeing, take time to relax at your chosen hotel in Thessaloniki, where you’ll be staying for 1 night.

Your adventure in Kalambaka is only getting started when you visit Archaeological Park Of Dion, a worthwhile local hot spot. Another notable attraction to explore is Enipeas Falls. This intriguing waterfall is known for its stunning appeal.

After soaking in the highlights of these sights, take some time to wander Kalambaka's streets and immerse yourself in the local atmosphere. When you're ready to continue your sightseeing adventure, head to Platamon Castle. This visually striking castle offers a fascinating experience that many visitors find memorable.

When you’re done exploring for the day, you’ll drive to your hotel in Thessaloniki. Check in and relax before you head out to tour the city.

After a day of adventure, treat yourself to an exquisite dinner at one of Thessaloniki's best restaurants.

Enjoy a delicious meal at Enoches Bar, a top-rated dining destination in Thessaloniki. If you're in the mood to try something new, consider O Loytros, another top spot with a mouthwatering menu. You might also want to secure a reservation at rOOTS. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Thessaloniki this evening.

After enjoying a delightful dinner, why not delve into the vibrant local bar scene? You might want to spend the evening at Peiratis Cafe-bar, a well-loved spot among locals and tourists. Or, head to In Rock Cafe Bar. This bar boasts a welcoming environment that is perfect for winding down. You could also continue your night at Tribeca, another top-rated place in the area.

Savor another day of unforgettable experiences in Greece!

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Day 5

Day 5

  • Thessaloniki - Departure day
  • More
  • The Umbrellas by Zongolopoulos
  • More

Day 5 of your road trip in Greece is your departure day. This is your chance to catch a last glimpse of Thessaloniki before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

If you're up for some more sightseeing, we recommend visiting The Umbrellas Sculpture By Zogolopoulos, an enchanting art installation before you head out.

Make the most of your final day in Greece by visiting Thessaloniki’s iconic markets and shopping establishments in the buzzing Tsimiski Street. Secure the perfect souvenirs for your family and friends back home or buy yourself a remembrance of your amazing vacation. You can also browse through boutiques for stylish fashion choices.

Before you conclude your road trip in Greece, drop by another restaurant for a last chance at a memorable dining experience in Thessaloniki.

Dine in style at Millet, a top recommendation for dinner tonight. Or, for a change of pace, Agora Ouzeri boasts a menu that's sure to impress.

You’ll then say farewell to Thessaloniki. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Greece!

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Shortly after booking, you’ll receive your full itinerary, including schedules, locations, and everything you need for a stress-free trip.
Personalize your itinerary
Each package includes a professionally crafted itinerary you can tailor to your travel style. A dedicated travel expert will make sure every detail fits your needs perfectly.
Easily make changes
Need to update plans? No problem. Whether before your trip or mid-journey, we’re just seconds away to help with quick adjustments.
Enjoy seamless planning
With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.
Explore with confidence
From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.
Secure your spot
Confirm your package instantly and lock in the best rate with secure payment and guaranteed availability.
Get instant confirmation
Shortly after booking, you’ll receive your full itinerary, including schedules, locations, and everything you need for a stress-free trip.
Personalize your itinerary
Each package includes a professionally crafted itinerary you can tailor to your travel style. A dedicated travel expert will make sure every detail fits your needs perfectly.
Easily make changes
Need to update plans? No problem. Whether before your trip or mid-journey, we’re just seconds away to help with quick adjustments.
Enjoy seamless planning
With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.
Explore with confidence
From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.

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Your trip is protected, personalized, and priced right. No surprises, no stress.

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