5-Day Greece Self-Drive Road Trip With Itinerary from Thessaloniki traveling south to Larissa
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Experience the freedom of the open road in Greece as you embark on an unforgettable 5-day road trip! This experience caters to every traveler, featuring destinations like Thessaloniki, Edessa, Larissa, Trikala, and Kastraki.
This perfectly planned road trip itinerary in Greece takes you through some of the best places to see in the country. You will spend 3 nights in Thessaloniki and 1 night in Larissa. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!
With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Greece. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have got you covered.
Upon arriving in Thessaloniki, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Greece on your own terms.
An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Greece. White Tower Of Thessaloniki and Aristotelous Square are just a couple of the bucket-list attractions that await your discovery.
As you hit the open road and drive through Thessaloniki, Edessa, Larissa, Trikala, and Kastraki, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Greece. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Greece.
Throughout your road trip in Greece, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Greece.
This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodation, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.
The best services in Greece fill up quickly, so book your spot early. Select a date and start planning your road trip in Greece today!
Itinerary summary
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Day 1 – Thessaloniki - arrival day
- Thessaloniki - Arrival day
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- Aristotelous Square
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Welcome to Thessaloniki, the perfect starting point for your road trip in Greece! Pick up your rental car and let the adventure begin. You will spend 2 nights immersing yourself in Thessaloniki's charm before embarking on the next leg of your journey.
Thessaloniki is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out Aristotelous Square or taking a stroll in the city center. Soak in the lovely atmosphere and sit down for a bit to eat or drink.
Find your way to your hotel in Thessaloniki. We recommend choosing a hotel in a central location for easy exploring. Check-in typically starts between 2 and 4 PM at hotels in Greece. Settle in and make plans for the evening.
As dinnertime approaches, it's time to head out for a bite to eat in Thessaloniki. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.
Dine in style at Kitchen Bar, a top recommendation for dinner tonight. Or, for a change of pace, The Greek boasts a menu that's sure to impress. Also, be sure to check out Phanós. Known as a local hotspot, it’s a great choice for tonight in Thessaloniki.
To truly maximize your evening out, consider visiting Beetle Bar after dinner. This bar is known for offering some of the best drinks and vibes in the city. Alternatively, head to Vogatsikou 3, another bar with an inviting ambiance. Similarly, Souel also offers a great atmosphere, ensuring a night filled with enjoyment and relaxation.
Raise a toast to the start of your 5-day road trip in Greece!
Day 2 – Thessaloniki
- Thessaloniki
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Drive 11 km, 56 min
- The Umbrellas by Zongolopoulos
- Archaeological Museum of Thessaloniki
- White Tower of Thessaloniki
- Heptapyrgion of Thessalonica
- Acropolis of Thessaloniki
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Day 2 offers a multitude of experiences. You will stay in Thessaloniki for 1 night more, offering you enough time to explore at a relaxed pace.
Set out on a day brimming with a romantic, a gorgeous, an eye-catching, a masterful, a historic, and a culturally significant. Start at the locally renowned The Umbrellas Sculpture By Zogolopoulos, a visually striking art installation in Thessaloniki. Next, go to Archaeological Museum Of Thessaloniki.
After visiting The Umbrellas Sculpture By Zogolopoulos and Archaeological Museum Of Thessaloniki, take time to explore Thessaloniki's streets and absorb its charm. Continue your sightseeing by heading to White Tower Of Thessaloniki. This picture-perfect monument offers a unique experience. Heptapyrgion Of Thessaloniki is another noteworthy stop.
Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Greece is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.
As dinnertime approaches, it's time to head out for a bite to eat in Thessaloniki. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.
Have a fantastic dining experience at Mamalouka, a highly recommended choice for tonight's dinner. If you're looking to mix things up, Clochard offers an enticing alternative with its varied menu. Additionally, Sofi's House Restaurant is worth considering. Renowned for satisfying diners, it’s an ideal option for tonight in Thessaloniki.
Continue the enjoyment post-dinner at Castra- All Day Terrace Bar, a cherished local gathering spot renowned for its welcoming atmosphere. Similarly, Barbaben - Bar/ba/ben offers a vibrant space for indulging in well-crafted drinks and engaging conversation. You may also want to check out Apallou. This bar is a favorite among both locals and visitors looking for a delightful evening out filled with laughter and fun.
Take some time to reflect on your day and savor another beautiful night in Greece.
Day 3 – Thessaloniki, Edessa, and Larissa
- Thessaloniki
- Edessa
- Thessaly and Central Greece
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Drive 281 km, 4 hours 12 min
- Atatürk Museum
- Arch of Galerius
- Kapani
- Edessa Waterfalls
- White Tower of Thessaloniki
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Embark on another extraordinary experience on day 3 of your road trip in Greece. Today, you will make 2 stops and experience some of the highlights of Thessaloniki and Edessa. At the end of the day, you will enjoy the comforts of a top-rated hotel in Larissa, which will be your home away from home for 1 night.
Thessaloniki is home to plenty of attractions that offer a picture-perfect, a history-steeped, and a culturally significant! Start at Atatürk Museum, an up-and-coming museum that is worthwhile a visit in the city. Nearby, you’ll find Arch Of Galerius And Rotunda, enchanting visitors with its history-steeped appeal. Continue your exploration at Kapani. This market is one of the city’s most well-known spots.
Once you're ready to continue your road trip, it's time to buckle up and drive, eagerly anticipating your arrival in Edessa. This drive usually takes around 1 hour 20 min, without any stops or traffic disruptions.
Your self-guided tour starts at Waterfalls Park, Edessa, a captivating waterfall that is sure to impress. Take in the surroundings and enjoy the freedom of exploring before you continue your journey.
At the end of the day, you will drive to Larissa, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.
After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Larissa. Enjoy a satisfying meal that will recharge you for tonight's adventures.
Treat yourself to a delicious dinner at Nonna Rossa, an excellent option for tonight's dining. Looking for something different? Vosporos | Restaurant • Bar offers a tantalizing alternative with its diverse menu. And don’t miss THE ALLEY. With its reputation for pleasing customers, it’s a fantastic choice for tonight in Larissa.
Continue your evening by exploring the vibrant nightlife scene at Sherlock Easy Bar, a prime destination for a thrilling night out. Also, don’t forget to check out Kiou, a bar that offers unique local touches. Likewise, Wisedog provides an excellent alternative for a fun evening.
Say good night to Larissa and look forward to another great day of your road trip in Greece!
Day 4 – Larissa, Trikala, Kastraki, and Thessaloniki
- Thessaly and Central Greece
- Trikala
- Kastraki
- Thessaloniki
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Drive 321 km, 4 hours 51 min
- Matsopoulos Park
- The Great Meteoron Holy Monastery of the Transfiguration of the Saviour
- Meteora
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On day 4 of your exciting self-drive vacation in Greece, you’ll soak in the magnificence of 2 destinations, Trikala and Kastraki. When you’re not sightseeing, take time to relax at your selected hotel in Thessaloniki, where you’ll be staying for 1 night.
Fasten your seatbelt and make your way to your next stop. Trikala, home to many well-known sights in the region, is a lovely destination on today’s itinerary. Keep in mind that your travel time from Larissa to Trikala may take around 56 min without traffic disruptions. Upon arrival in Trikala, we highly recommend checking out some of the top attractions.
Matsopoulos Park is a worthwhile park we recommend making time to visit today. Discover its stunning features before continuing your self-guided tour.
Fasten your seatbelt and make your way to your next stop. Kastraki, home to many well-known sights in the region, is a lovely destination on today’s itinerary. Keep in mind that your travel time from Trikala to Kastraki may take around 37 min without traffic disruptions. Upon arrival in Kastraki, we highly recommend checking out some of the top attractions.
Make your way to Holy Monastery Of The Great Meteoron -transfiguration Of The Saviour, an up-and-coming monastery that draws attention for its breathtaking features. Spend some time soaking in the atmosphere before continuing to Meteora, an inviting monastery that stands out in the city.
After soaking up all the sights of today's itinerary, you'll be ready to hit the road in the direction of your accommodation in Thessaloniki. Thessaloniki offers plenty of top-rated hotels and other places to stay on any travel budget. Take some time to relax before you head out to explore.
After a day of adventure, treat yourself to an exquisite dinner at one of Thessaloniki's best restaurants.
Dine in style at Enoches Bar, a top recommendation for dinner tonight. Or, for a change of pace, O Loytros boasts a menu that's sure to impress. Also, be sure to check out rOOTS. Known as a local hotspot, it’s a great choice for tonight in Thessaloniki.
Let the evening flow smoothly from dinner to drinks at Peiratis Cafe-bar, a top-rated bar in the area. For other recommendations, In Rock Cafe Bar provides a perfect setting for rounding out your night with style and great drinks. Likewise, Tribeca offers a memorable night with diverse drink options and excellent service.
Savor another day of unforgettable experiences in Greece!
Day 5 – Thessaloniki - departure day
- Thessaloniki - Departure day
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- Agias Sofias Square
- White Tower of Thessaloniki
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Day 5 of your road trip in Greece is your departure day. This is your chance to catch a last glimpse of Thessaloniki before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.
On your last day in Greece, take time to indulge in shopping at Thessaloniki’s popular marketplace. Look for keepsakes or souvenirs to remind you of your trip.
Before you conclude your road trip in Greece, drop by another restaurant for a last chance at a memorable dining experience in Thessaloniki.
If you're eager to try something different, consider Agora Ouzeri, another top spot with a tantalizing menu.
You’ll then say farewell to Thessaloniki. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Greece!
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