5-Day Greece Self-Drive Road Trip With Itinerary from Thessaloniki traveling south to Trikala and Larissa

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Photo of bird's eye view to the promenade of Thessaloniki.
Photo of Saint Paul cathedral in Thessaloniki, Greece.
5-Day Greece Self-Drive Road Trip With Itinerary from Thessaloniki traveling south to Trikala and Larissa
5-Day Greece Self-Drive Road Trip With Itinerary from Thessaloniki traveling south to Trikala and Larissa
5-Day Greece Self-Drive Road Trip With Itinerary from Thessaloniki traveling south to Trikala and Larissa
5-Day Greece Self-Drive Road Trip With Itinerary from Thessaloniki traveling south to Trikala and Larissa
5-Day Greece Self-Drive Road Trip With Itinerary from Thessaloniki traveling south to Trikala and Larissa
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Experience the freedom of the open road on an unforgettable 5-day road trip in Greece! Embark on a self-drive tour that caters to every traveler, featuring destinations like Thessaloniki, Trikala, Kastraki, Larissa, Katerini, Vergina, and Kastanéa.

This perfectly planned road trip itinerary takes you through some of the best places to see in Greece. You will spend 2 nights in Thessaloniki, 1 night in Trikala, and 1 night in Larissa. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Greece. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have you covered.

Upon arriving in Thessaloniki, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Greece on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Greece. White Tower Of Thessaloniki and Aristotelous Square are just a couple of the bucket-list attractions that await your discovery.

As you hit the open road and drive through Thessaloniki, Trikala, Kastraki, Larissa, Katerini, Vergina, and Kastanéa, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Greece. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Greece.

Throughout your road trip in Greece, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Greece.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodations, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in Greece fill up quickly, so book your spot early. Select a date and start planning your road trip in Greece today!

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Driver’s age is 30 - 65
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Day1

Day 1

  • Thessaloniki - Arrival day
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  • Ladadika
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Say hello to Thessaloniki! Your exciting road trip through Greece is just about to start. Navigating the top places to see in the region is a breeze with a car. The rental vehicle of your choice will be ready for pickup upon your arrival in the city. You will stay in Thessaloniki for 1 night before you continue your adventure!

Thessaloniki is a beautiful city with plenty to discover. Taking a stroll in the city center is a great alternative. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

When you're ready for some downtime, make your way to your chosen hotel. Check-in typically starts between 2 and 4 PM in Thessaloniki. Make yourself at home and unwind before heading out again.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Thessaloniki, it's often a good idea to reserve a table in advance.

Have a fantastic dining experience at Kitchen Bar, a highly recommended choice for tonight's dinner. If you're looking to mix things up, The Greek offers an enticing alternative with its varied menu. Additionally, Phanós is worth considering. Renowned for satisfying diners, it’s an ideal option for tonight in Thessaloniki.

Continue the enjoyment post-dinner at Beetle Bar, a cherished local gathering spot renowned for its welcoming atmosphere. Similarly, Vogatsikou 3 offers a vibrant space for indulging in well-crafted drinks and engaging conversation. You may also want to check out Souel. This bar is a favorite among both locals and visitors looking for a delightful evening out filled with laughter and fun.

Raise a toast to the start of your 5-day road trip in Greece!

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Day2

Day 2

  • Thessaloniki
  • Trikala
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Drive 217 km, 3 hours 15 min

  • Aristotelous Square
  • Agias Sofias Square
  • Arch of Galerius
  • White Tower of Thessaloniki
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Experience an unparalleled adventure on day 2 of your road trip in Greece. This exciting part of your journey invites you to discover the renowned landmarks in 1 place, which are Thessaloniki. At the end of the day, you will retreat to the hotel of your choice in Trikala, where will spend 1 night.

Visiting Aristotelous Square is always a good idea. This notable public square is a place that is appreciated by travelers and locals alike. Next, immerse yourself in the photogenic wonders of Agias Sofias Square, a must-see public square in the city.

Consider stopping for a small bite to eat or a drink at a local eatery to keep your energy going. When you’re ready, continue your discovery with a visit to Arch Of Galerius And Rotunda. This notable monument offers an enriching experience. For a change of pace, head to White Tower Of Thessaloniki, where you can take in picture-perfect features.

At the end of the day, you will drive to Trikala, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Trikala. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Treat yourself to a wonderful meal at ALVEO, a top-rated dining spot in Trikala. If you're in the mood for something new, try Trikala Fortress, another premier location with a delectable menu. You might also want to book a table at Palia Istoria. Known for its consistently satisfied patrons, it’s a perfect choice to elevate your evening in Trikala.

Following your dinner, dive into the local bar culture at Soyita Art Cafe. Enjoy this evening's relaxed ambiance with delightful drinks. Alternatively, go to Factory Café, the perfect place for those looking to experience the best of the nightlife. Similarly, The Love Shake provides excellent drinks and a great atmosphere, ensuring a memorable night out.

Take some time to reflect on your day and savor another beautiful night in Greece.

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Day3

Day 3

  • Trikala
  • Kastraki
  • Larissa
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Drive 118 km, 2 hours 53 min

  • Matsopoulos Park
  • The Great Meteoron Holy Monastery of the Transfiguration of the Saviour
  • Monastery of Varlaam
  • Meteora
  • More

On day 3 of your road trip in Greece, your travel plans include 2 stops at the most scenic, wondrous, and interesting places in the region. Trikala and Kastraki are on today's agenda. In the evening, you’ll end up in Larissa, where you will stay for 1 night.

Let Matsopoulos Park set the tone for the day. Spend some time admiring this picturesque park before continuing your journey.

When you’ve had your share of Trikala, prepare for your next destination. Admire the views and listen to some good music as you drive in the direction of Kastraki. Your travel time is around 37 min.

Spend your afternoon discovering Holy Monastery Of The Great Meteoron -transfiguration Of The Saviour, a curiosity-inducing monastery known for its picture-perfect features. Next, continue your sightseeing at Monastery Of Varlaam, an often recommended monastery.

If you're starting to feel hungry, this is a great time for a break at a nearby restaurant or cafe. When you're ready for more, stop by Meteora and uncover the details of this history-steeped monastery.

After soaking up all the sights on today's itinerary, you'll be ready to head to your accommodation in Larissa. Larissa offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

Indulge in a memorable dining experience at one of Larissa's most popular restaurants, and connect with friendly locals for a true cultural experience.

Make sure to reserve a table at Nonna Rossa, an iconic dining spot in Larissa. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Vosporos | Restaurant • Bar, a popular restaurant in Larissa. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of THE ALLEY, a hidden gem nestled in Larissa. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

Continue your evening by exploring the vibrant nightlife scene at Sherlock Easy Bar, a prime destination for a thrilling night out. Also, don’t forget to check out Kiou, a bar that offers unique local touches. Likewise, Wisedog provides an excellent alternative for a fun evening.

Celebrate another amazing day of your road trip adventure in Greece!

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Day4

Day 4

  • Larissa
  • Katerini
  • Vergina
  • Kastanéa
  • Thessaloniki
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Drive 259 km, 4 hours 15 min

  • Katerini Municipal Park
  • Museum of the Royal Tombs at Aigai (Aegae)
  • Holy Monastery of the Virgin Mary Soumela
  • More

On day 4 of your exciting self-drive vacation in Greece, you’ll soak in the magnificence of 3 destinations, including Katerini, Vergina, and Kastanéa. When you’re not sightseeing, take time to relax at your chosen hotel in Thessaloniki, where you’ll be staying for 1 night.

Katerini’s wonders await as you prepare for another journey on the road, leaving the breathtaking surroundings of Larissa behind. This drive usually takes around 1 hour 5 min. Katerini welcomes you with a multitude of unique vacation experiences.

One of our top recommendations for your sightseeing is Katerini Municipal Park. Spend some time admiring the serene features of the park before you continue to your next stop.

Vergina’s wonders await as you prepare for another journey on the road, leaving the breathtaking surroundings of Katerini behind. This drive usually takes around 53 min. Vergina welcomes you with a multitude of unique vacation experiences.

When you're ready for some sights, head to Museum Of The Royal Tombs At Aigai (aegae), a frequently visited museum in Vergina. Explore its heritage-rich features at your own pace before you continue your journey.

Set your GPS to Kastanéa and hit the road. Expect a journey of approximately 40 min without stops. Soak in the beautiful landscapes as you drive and look forward to exploring your next destination. Kastanéa beckons with new experiences!

Holy Shrine Of The Virgin Mary Soumela is a locally appreciated church we recommend visiting today. Discover its breathtaking features before continuing your self-guided tour.

When you’re done exploring for the day, you’ll drive to your hotel in Thessaloniki. Check in and relax before you head out to tour the city.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Thessaloniki, it's often a good idea to reserve a table in advance.

Savor the flavors at Mamalouka, a top pick for dinner tonight. Alternatively, Clochard beckons with its unique menu offerings. Also, consider Sofi's House Restaurant. With its consistent customer satisfaction, it’s an excellent option for dining in Thessaloniki tonight.

Keep the evening going at Castra- All Day Terrace Bar, a great choice for enjoying the after-dinner hours with a drink. You could also go to Barbaben - Bar/ba/ben, which offers a similarly pleasant setting and great drinks. Another option is Apallou, which provides an inviting environment for unwinding after a busy day out.

Relax and recharge in preparation for another adventurous day in Greece!

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Day5

Day 5

  • Thessaloniki - Departure day
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  • The Umbrellas by Zongolopoulos
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Day 5 of your road trip in Greece is your departure day. This is your chance to catch a last glimpse of Thessaloniki before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

If you're up for some more sightseeing, we recommend visiting The Umbrellas Sculpture By Zogolopoulos, a visually striking art installation before you head out.

For a shopping spree in Thessaloniki, we recommend the lively Modiano Market. Here, you'll find a range of shops you can browse for some souvenir shopping.

Before you conclude your road trip in Greece, drop by another restaurant for a last chance at a memorable dining experience in Thessaloniki.

Treat yourself to a delightful dinner at Enoches Bar, highly recommended for tonight's dining. Or, if you're feeling adventurous, why not try O Loytros? It's another excellent option with a diverse menu.

You’ll then say farewell to Thessaloniki. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Greece!

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Need to update plans? No problem. Whether before your trip or mid-journey, we’re just seconds away to help with quick adjustments.
Enjoy seamless planning
With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.
Explore with confidence
From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.
Secure your spot
Confirm your package instantly and lock in the best rate with secure payment and guaranteed availability.
Get instant confirmation
Shortly after booking, you’ll receive your full itinerary, including schedules, locations, and everything you need for a stress-free trip.
Personalize your itinerary
Each package includes a professionally crafted itinerary you can tailor to your travel style. A dedicated travel expert will make sure every detail fits your needs perfectly.
Easily make changes
Need to update plans? No problem. Whether before your trip or mid-journey, we’re just seconds away to help with quick adjustments.
Enjoy seamless planning
With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.
Explore with confidence
From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.

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Your trip is protected, personalized, and priced right. No surprises, no stress.

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