6-Day Greece Self-Drive Road Trip With Itinerary from Thessaloniki to Kalambaka and Ioannina

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Photo of Saint Paul cathedral in Thessaloniki, Greece.
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Experience the freedom of the open road in Greece as you embark on an unforgettable 6-day road trip! This experience caters to every traveler, featuring destinations like Thessaloniki, Kastraki, Kalambaka, Ioannina, Anilio, and Metsovo.

This perfectly planned road trip itinerary in Greece takes you through some of the best places to see in the country. You will spend 3 nights in Thessaloniki, 1 night in Kalambaka, and 1 night in Ioannina. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Greece. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have got you covered.

Upon arriving in Thessaloniki, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Greece on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Greece. White Tower Of Thessaloniki and Aristotelous Square are just a couple of the bucket-list attractions that await your discovery. Marvel at the remarkable The Umbrellas Sculpture By Zogolopoulos, learn more about the unique Arch Of Galerius And Rotunda, and immerse yourself in the vibrant atmosphere of Ioannina Castle.

As you hit the open road and drive through Thessaloniki, Kastraki, Kalambaka, Ioannina, Anilio, and Metsovo, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Greece. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Greece.

Throughout your road trip in Greece, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Greece.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodation, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in Greece fill up quickly, so book your spot early. Select a date and start planning your road trip in Greece today!

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Day 1

Day 1

  • Thessaloniki - Arrival day
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  • Ladadika
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Welcome to Thessaloniki, the perfect starting point for your road trip in Greece! Pick up your rental car and let the adventure begin. You will spend 2 nights immersing yourself in Thessaloniki's charm before embarking on the next leg of your journey.

Thessaloniki is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out Ladadika, a must-see neighborhood, and taking a stroll in the city center. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

As afternoon approaches, head to your chosen hotel in Thessaloniki. Check-in typically starts around 2 to 4 PM at hotels in Greece. We recommend staying at a hotel in a central location for easy access to the best attractions, restaurants, and bars in the city.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Thessaloniki, it's often a good idea to reserve a table in advance.

Have a fantastic dining experience at Kitchen Bar, a highly recommended choice for tonight's dinner. If you're looking to mix things up, The Greek offers an enticing alternative with its varied menu. Additionally, Phanós is worth considering. Renowned for satisfying diners, it’s an ideal option for tonight in Thessaloniki.

Continue your evening by exploring the vibrant nightlife scene at Beetle Bar, a prime destination for a thrilling night out. Also, don’t forget to check out Vogatsikou 3, a bar that offers unique local touches. Likewise, Souel provides an excellent alternative for a fun evening.

Raise a toast to the start of your 6-day road trip in Greece!

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Day 2

Day 2

  • Thessaloniki
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Drive 6 km, 1 hour 4 min

  • The Umbrellas by Zongolopoulos
  • Archaeological Museum of Thessaloniki
  • White Tower of Thessaloniki
  • Agias Sofias Square
  • Aristotelous Square
  • Tsimiski Street
  • More

Day 2 of your road trip will take you to the best attractions Thessaloniki has to offer. Cherish the 1 night you have left in Thessaloniki by discovering the best things there are to see and do in the city.

At the top of the list of things to do today is to explore Tsimiski Street, a street that captures the true essence of Thessaloniki. Take your time to uncover its best sides and enjoy its proximity to many of the area’s best attractions.

Today’s route brings fun adventures, romantic experiences, and breathtaking views. The first attraction of today is The Umbrellas Sculpture By Zogolopoulos. This popular art installation is an enchanting place to see in Thessaloniki. Continue your discovery at Archaeological Museum Of Thessaloniki, a respected museum with stories to tell.

As you stroll around Thessaloniki, take in the distinct atmosphere and learn what makes this city so unique. Maximize your sightseeing with a visit to White Tower Of Thessaloniki. This spectacular monument offers a standout encounter with Thessaloniki. Next, make your way to Agias Sofias Square to add another highlight to your day. After that, visit Aristotelous Square, a captivating public square that’s sure to impress. Whether you decide to get entrance tickets for all attractions or you prefer admiring from a distance, amazing experiences await on this day in Thessaloniki.

Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Greece is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.

As dinnertime approaches, it's time to head out for a bite to eat in Thessaloniki. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.

Make sure to reserve a table at Mamalouka, an iconic dining spot in Thessaloniki. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Clochard, a popular restaurant in Thessaloniki. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of Sofi's House Restaurant, a hidden gem nestled in Thessaloniki. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

Cap off your culinary experience with a visit to some of the most celebrated bars in the area. For instance, Castra- All Day Terrace Bar stands out as an excellent choice for a post-dinner cocktail. Alternatively, Barbaben - Bar/ba/ben offers an ideal atmosphere to enjoy the pleasures of the night. Apallou is also a great option that provides a perfect setting for a relaxing evening.

Savor another day of unforgettable experiences in Greece!

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Day 3

Day 3

  • Thessaloniki
  • Meteora
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Drive 240 km, 3 hours 33 min

  • The Great Meteoron Holy Monastery of the Transfiguration of the Saviour
  • Monastery of Varlaam
  • Main Observation Deck of Meteora
  • Natural History Museum of Meteora and Mushroom Museum
  • Greek Education Museum
  • More

On day 3 of your road trip in Greece, you will get a true taste of the freedom a self-drive vacation in Europe entails. Today’s travel plans include stops at the most scenic, wondrous, and interesting places in Kastraki and Kalambaka. In the evening, you’ll end up in Kalambaka, where you will stay for 1 night.

Get ready to discover some of the most iconic wonders in Thessaloniki, including a monastery, an observation deck, and a museum. Start your day at Holy Monastery Of The Great Meteoron -transfiguration Of The Saviour. This breathtaking monastery is a locally appreciated place to see in Thessaloniki. Then, wander over to Monastery Of Varlaam. If breathtaking sites excite you, this monastery will be right up your alley. Nearby, you’ll also find Main Observation Deck Of Meteora. This standout observation deck is a favorite among visitors.

Thessaloniki offers plenty to explore, ensuring every moment of your visit is filled with excitement and discovery. If you're up for more, Natural History Museum Of Meteora And Mushroom Museum is an increasingly popular spot in the village that will captivate you with its unique charm. When you’re done at the museum, don’t forget to check out the standout Greek Education Museum. Take a moment to appreciate the fascinating details of this curiosity-inducing museum.

After soaking up all the sights of today's itinerary, you'll be ready to head in the direction of your accommodation in Kalambaka. Kalambaka offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

As you explore more of Kalambaka, you'll discover that its culinary landscape is as diverse as its attractions. Whether you're craving traditional dishes bursting with local flavors or innovative creations that push the boundaries of taste, you're sure to find a dining experience that satisfies your cravings.

Raise your glass and celebrate another amazing day of your road trip in Greece!

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Day 4

Day 4

  • Meteora
  • Ioannina
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Drive 106 km, 2 hours 26 min

  • Silversmithing Museum
  • Ich Kale Acropolis of Ioannina
  • Museum "Arslan Pasha"
  • Ioannina Castle
  • Litharitsia park
  • The Clock Tower of Ioannina
  • More

Embark on another extraordinary experience on day 4 of your road trip in Greece. Today, you will make 1 stop and experience some of the highlights of Ioannina. At the end of the day, you will enjoy the comforts of a top-rated hotel in Ioannina, which will be your home away from home for 1 night.

Start your day with a visit to Silversmithing Museum Of Ioannina. This up-and-coming museum is a must-visit in the city. When you’re ready for your next discovery, continue to Ic Kale Acropolis Of Ioannina, which may be one of the most respected places you will experience today.

One of the best things about exploring Kalambaka on a self-guided tour is that you set the pace. There’s plenty of time for detours and discovering hidden gems. When you’re ready for your next stop, make your way to Museum "arslan Pasha", an underrated point of interest in the city. If you’re up for more discoveries, don’t forget to reserve some time for Ioannina Castle and Litharitsia Park. End your day with a visit to The Clock Tower Of Ioannina, a curiosity-inducing monument that’s sure to leave a lasting impression.

When you’re done exploring for the day, you’ll drive to your hotel in Ioannina. Check in and spend some time relaxing before you head out to tour the city.

As dinnertime approaches, it's time to head out for a bite to eat in Ioannina. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.

Make sure to reserve a table at To Dodeka Cafe Bar, an iconic dining spot in Ioannina. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Mustagogia, a popular restaurant in Ioannina. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of Accademia Del Panino, a hidden gem nestled in Ioannina. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

Cap off your culinary experience with a visit to some of the most celebrated bars in the area. For instance, ⚜ V E D E M A ⚜ stands out as an excellent choice for a post-dinner cocktail. Alternatively, Hogwarts Tales And Spirits offers an ideal atmosphere to enjoy the pleasures of the night. Chevalier is also a great option that provides a perfect setting for a relaxing evening.

Head back to your accommodation in Ioannina and get some rest in preparation for another magical day of your road trip in Greece!

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Day 5

Day 5

  • Ioannina
  • Thessaloniki
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Drive 270 km, 3 hours 53 min

  • Καταρράκτης Ανήλιου
  • Averoff Art Gallery
  • Metsovo square
  • Metsovo Folk Art Museum (Tossizza Mansion)
  • Αβερώφειος Κήπος
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On day 5 of your exciting self-drive vacation in Greece, you’ll soak in the magnificence of 2 destinations, Anilio and Metsovo. When you’re not sightseeing, take time to relax at your selected hotel in Thessaloniki, where you’ll be staying for 1 night.

Today’s well-planned self-sightseeing route offers several fun adventures, romantic experiences, and natural wonders. Whether you decide to explore Ioannina on foot, use public transport, or join a guided tour, there are a few attractions you don’t want to miss. Katarraktis Anilioy is the first of them. Spend some time admiring this eye-catching waterfall before continuing your journey. Averoff Art Gallery is your next stop. This worthwhile art gallery is one of the best-rated sights in Ioannina.

Consider grabbing some lunch or a light snack to keep your energy going. Beyond the above-mentioned attractions, today is also the perfect time to visit Metsovo Square. This romantic public square is a sight to behold. To round off your sightseeing experience, visit Metsovo Folk Art Museum (tossizza Mansion) and Averofeios Kipos.

At the end of the day, you will drive to Thessaloniki, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

After a day of adventure, treat yourself to an exquisite dinner at one of Thessaloniki's best restaurants.

Make sure to reserve a table at Enoches Bar, an iconic dining spot in Thessaloniki. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of O Loytros, a popular restaurant in Thessaloniki. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of rOOTS, a hidden gem nestled in Thessaloniki. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

Round off your dining experience by visiting Peiratis Cafe-bar, a prime location for a drink. Alternatively, explore the distinctive characteristics of In Rock Cafe Bar, a bar catering to every mood and preference. Tribeca likewise offers a unique atmosphere, perfect for a memorable night out.

Get a good night's sleep and look forward to another great day on the road in Greece!

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Day 6

Day 6

  • Thessaloniki - Departure day
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  • Arch of Galerius
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Day 6 of your road trip in Greece is your departure day. This is your chance to catch a last glimpse of Thessaloniki before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

If you're up for some more sightseeing, begin at Arch Of Galerius And Rotunda. This popular monument is a popular place to see in the city.

As your final day in Greece unfolds, enjoy a last-minute shopping spree in Thessaloniki's best shopping area, Modiano Market. Enjoy finding the perfect gift or keepsake to remind you of your wonderful trip to Greece.

Before you conclude your road trip in Greece, drop by another restaurant for a last chance at a memorable dining experience in Thessaloniki.

Have a fantastic dining experience at Millet, a highly recommended choice for tonight's dinner. If you're looking to mix things up, Agora Ouzeri offers an enticing alternative with its varied menu.

You’ll then say farewell to Thessaloniki. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Greece!

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Shortly after booking, you’ll receive your full itinerary, including schedules, locations, and everything you need for a stress-free trip.
Personalize your itinerary
Each package includes a professionally crafted itinerary you can tailor to your travel style. A dedicated travel expert will make sure every detail fits your needs perfectly.
Easily make changes
Need to update plans? No problem. Whether before your trip or mid-journey, we’re just seconds away to help with quick adjustments.
Enjoy seamless planning
With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.
Explore with confidence
From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.
Secure your spot
Confirm your package instantly and lock in the best rate with secure payment and guaranteed availability.
Get instant confirmation
Shortly after booking, you’ll receive your full itinerary, including schedules, locations, and everything you need for a stress-free trip.
Personalize your itinerary
Each package includes a professionally crafted itinerary you can tailor to your travel style. A dedicated travel expert will make sure every detail fits your needs perfectly.
Easily make changes
Need to update plans? No problem. Whether before your trip or mid-journey, we’re just seconds away to help with quick adjustments.
Enjoy seamless planning
With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.
Explore with confidence
From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.

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Your trip is protected, personalized, and priced right. No surprises, no stress.

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