6-Day Greece Self-Drive Road Trip With Itinerary from Thessaloniki to Kalambaka and Ioannina

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Photo of Saint Paul cathedral in Thessaloniki, Greece.
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Explore the best of Greece on a remarkable 6-day road trip! Combine exploration with relaxation on a self-drive tour featuring Thessaloniki, Kastraki, Kalambaka, Ioannina, Anilio, and Metsovo.

This perfectly planned road trip itinerary takes you through some of the best places to see in Greece. You will spend 3 nights in Thessaloniki, 1 night in Kalambaka, and 1 night in Ioannina. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Greece. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have you covered.

Upon arriving in Thessaloniki, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Greece on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Greece. White Tower Of Thessaloniki and Aristotelous Square are just a couple of the bucket-list attractions that await your discovery.

As you hit the open road and drive through Thessaloniki, Kastraki, Kalambaka, Ioannina, Anilio, and Metsovo, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Greece. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Greece.

Throughout your road trip in Greece, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Greece.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodations, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in Greece fill up quickly, so book your spot early. Select a date and start planning your road trip in Greece today!

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Driver’s age is 30 - 65
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Pick-up: 10:00
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Day1

Day 1

  • Thessaloniki - Arrival day
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  • Ladadika
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Welcome to Thessaloniki, the perfect starting point for your road trip in Greece! Pick up your rental car and let the adventure begin. You will spend 2 nights discovering what to see in Thessaloniki before embarking on the next leg of your journey.

Thessaloniki is a beautiful city with plenty to discover. Taking a stroll in the city center is a great alternative. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

Find your way to your hotel in Thessaloniki. We recommend choosing a hotel in a central location for easy exploring. Check-in typically starts between 2 and 4 PM at hotels in Greece. Settle in and make plans for the evening.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Thessaloniki, it's often a good idea to reserve a table in advance.

Savor the flavors at Kitchen Bar, a top pick for dinner tonight. Alternatively, The Greek beckons with its unique menu offerings. Also, consider Phanós. With its consistent customer satisfaction, it’s an excellent option for dining in Thessaloniki tonight.

Following your dinner, dive into the local bar culture at Beetle Bar. Enjoy this evening's relaxed ambiance with delightful drinks. Alternatively, go to Vogatsikou 3, the perfect place for those looking to experience the best of the nightlife. Similarly, Souel provides excellent drinks and a great atmosphere, ensuring a memorable night out.

Raise a toast to the start of your 6-day road trip in Greece!

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Day2

Day 2

  • Thessaloniki
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Drive 6 km, 1 hour 4 min

  • The Umbrellas by Zongolopoulos
  • Archaeological Museum of Thessaloniki
  • White Tower of Thessaloniki
  • Agias Sofias Square
  • Aristotelous Square
  • Tsimiski Street
  • More

Day 2 of your road trip will take you to the best attractions Thessaloniki has to offer. Cherish the 1 night you have left in the city and use the provided itinerary to discover what to see in Thessaloniki.

A visit to Tsimiski Street is a must on the agenda today. This street is full of hidden gems and character, perfect for a leisurely stroll. Plus, you’ll be close to some of the city’s most famous sights.

Make time for The Umbrellas Sculpture By Zogolopoulos, a well-known art installation that is worthwhile a visit in the city. Nearby, you’ll find Archaeological Museum Of Thessaloniki, enchanting visitors with its heritage-rich appeal. Continue your exploration at White Tower Of Thessaloniki. This monument is one of the city’s most top-rated spots.

Enjoy the freedom of exploring Thessaloniki at your own pace and find hidden gems along the way. If you want to see more picture-perfect spots, make sure to visit Agias Sofias Square. After exploring the public square, head to the captivating Aristotelous Square.

Don’t forget to check out all the popular tours and experiences you can add to your travel plans in Greece. You can explore and select activities under each day of your itinerary.

After a day of adventure, treat yourself to an exquisite dinner at one of Thessaloniki's best restaurants.

Treat yourself to a delicious dinner at Mamalouka, an excellent option for tonight's dining. Looking for something different? Clochard offers a tantalizing alternative with its diverse menu. And don’t miss Sofi's House Restaurant. Known for great service, it’s a fantastic choice for tonight in Thessaloniki.

After your meal, keep the night alive at a bar like Castra- All Day Terrace Bar, known for its lively atmosphere. Barbaben - Bar/ba/ben is another top recommendation that provides the perfect setting with well-crafted drinks and a welcoming ambiance. Similarly, Apallou offers an excellent atmosphere for those looking to amp up the evening.

As the day draws to a close, take a moment to unwind and prepare for the next exciting chapter of your road trip in Greece.

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Day3

Day 3

  • Thessaloniki
  • Meteora
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Drive 240 km, 3 hours 33 min

  • The Great Meteoron Holy Monastery of the Transfiguration of the Saviour
  • Monastery of Varlaam
  • Main Observation Deck of Meteora
  • Natural History Museum of Meteora and Mushroom Museum
  • Greek Education Museum
  • More

Dive into day 3 of your remarkable road trip in Greece. Today you'll explore 2 destinations, including Kastraki and Kalambaka. At the end of the day, you’ll unwind at one of the finest accommodations in Kalambaka, where you'll spend 1 night.

Awaiting your discovery is the up-and-coming Holy Monastery Of The Great Meteoron -transfiguration Of The Saviour, a respected monastery in Thessaloniki. Next, go to Monastery Of Varlaam.

After visiting Holy Monastery Of The Great Meteoron -transfiguration Of The Saviour and Monastery Of Varlaam, have a stroll along Thessaloniki's streets and take in the local charm. Continue your sightseeing by heading to Main Observation Deck Of Meteora. This mesmerizing observation deck offers a unique experience. Natural History Museum Of Meteora And Mushroom Museum is another noteworthy attraction worthwhile a visit. End your self-guided sightseeing tour on top with a visit to Greek Education Museum, one of the most visually striking places to visit in Thessaloniki.

When you’re done exploring for the day, you’ll drive to your hotel in Kalambaka. Check in and relax before you head out to tour the town.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Kalambaka. Enjoy a relaxing evening as you savor delicious local cuisine.

Relax and recharge in preparation for another adventurous day in Greece!

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Day4

Day 4

  • Meteora
  • Ioannina
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Drive 106 km, 2 hours 26 min

  • Silversmithing Museum
  • Ich Kale Acropolis of Ioannina
  • Museum "Arslan Pasha"
  • Ioannina Castle
  • Litharitsia park
  • The Clock Tower of Ioannina
  • More

On day 4 of your road trip in Greece, your travel plans include 1 stop at the most scenic, wondrous, and interesting places in the region. Ioannina are on today's agenda. In the evening, you’ll end up in Ioannina, where you will stay for 1 night.

Catch Silversmithing Museum Of Ioannina before the crowds roll in. This instagrammable museum is sure to ignite your curiosity. Next, dive into the historic features of Ic Kale Acropolis Of Ioannina, a must-visit archeological site in the city.

In between sights, stop by local stores, picturesque photo spots, and small eateries. When you’re ready for your next attraction, proceed to Museum "arslan Pasha", an intriguing sightseeing destination. For a change of scene, check out Ioannina Castle, known for its history-steeped features. We also recommend visiting Litharitsia Park. This park is a must for anyone looking to experience the city to the fullest. Lastly, end your day with a visit to The Clock Tower Of Ioannina, yet another often recommended attraction in Kalambaka.

At the end of the day, you will drive to Ioannina, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Ioannina. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Enjoy a delicious meal at To Dodeka Cafe Bar, a highly-rated dining destination in Ioannina. If you're eager to try something different, consider Mustagogia, another top spot with a tantalizing menu. You might also want to secure a reservation at Accademia Del Panino. With a reputation for consistently satisfying customers, it’s an excellent choice to enhance your stay in Ioannina this evening.

Continue your lively evening at ⚜ V E D E M A ⚜, a perfect place for winding down or revving up the night, depending on which mood you’re in. Hogwarts Tales And Spirits is another excellent bar that offers a great selection of drinks to suit any mood. If you prefer to go somewhere else, Chevalier ensures a night out tailored to your taste.

Take some time to reflect on your day and savor another beautiful night in Greece.

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Day5

Day 5

  • Ioannina
  • Thessaloniki
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Drive 270 km, 3 hours 53 min

  • Καταρράκτης Ανήλιου
  • Averoff Art Gallery
  • Metsovo square
  • Metsovo Folk Art Museum (Tossizza Mansion)
  • Αβερώφειος Κήπος
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Experience an unparalleled adventure on day 5 of your road trip in Greece. This exciting part of your journey invites you to discover the renowned landmarks in 2 places, which are Anilio and Metsovo. At the end of the day, you will retreat to the hotel of your choice in Thessaloniki, where will spend 1 night.

No visit to Ioannina is complete without Katarraktis Anilioy. This underrated waterfall is one of the top attractions in the village. Proceed to Averoff Art Gallery, another must-visit attraction.

As you wander through the inviting streets of Ioannina, soak in the lively ambiance and take the opportunity to snap some photos. Next, head to Metsovo Square. This underrated public square is a traveler-favorite. Not far away, you’ll find Metsovo Folk Art Museum (tossizza Mansion), another key site on your sightseeing itinerary. Averofeios Kipos is yet another highly recommended place to visit nearby, offering plenty to discover for curious travelers.

After soaking up all the sights on today's itinerary, you'll be ready to head to your accommodation in Thessaloniki. Thessaloniki offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

Thessaloniki is a place where the culinary landscape is as diverse as its attractions. So before the day ends, treat your palate to a taste of local cuisine at one of the best restaurants in Thessaloniki.

Make sure to reserve a table at Enoches Bar, an iconic dining spot in Thessaloniki. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of O Loytros, a popular restaurant in Thessaloniki. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of rOOTS, a hidden gem nestled in Thessaloniki. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

Cap off your dinner by heading to Peiratis Cafe-bar, ideal for a leisurely evening with a drink in hand. In Rock Cafe Bar is another bar that offers an enjoyable setting. Similarly, Tribeca is also a popular place to go on a night out, perfect for relaxing and socializing.

Raise your glass to another unforgettable day in Greece!

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Day6

Day 6

  • Thessaloniki - Departure day
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  • Arch of Galerius
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Day 6 of your road trip in Greece is your departure day. This is your chance to catch a last glimpse of Thessaloniki before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

If you're up for some more sightseeing, we recommend visiting Arch Of Galerius And Rotunda, a symbolic monument before you head out.

Make the most of your final day in Greece by visiting Thessaloniki’s iconic markets and shopping establishments in the buzzing Tsimiski Street. Secure the perfect souvenirs for your family and friends back home or buy yourself a remembrance of your amazing vacation. You can also browse through boutiques for stylish fashion choices.

Before you conclude your road trip in Greece, drop by another restaurant for a last chance at a memorable dining experience in Thessaloniki.

Dine in style at Millet, a top recommendation for dinner tonight. Or, for a change of pace, Agora Ouzeri boasts a menu that's sure to impress.

You’ll then say farewell to Thessaloniki. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Greece!

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Shortly after booking, you’ll receive your full itinerary, including schedules, locations, and everything you need for a stress-free trip.
Personalize your itinerary
Each package includes a professionally crafted itinerary you can tailor to your travel style. A dedicated travel expert will make sure every detail fits your needs perfectly.
Easily make changes
Need to update plans? No problem. Whether before your trip or mid-journey, we’re just seconds away to help with quick adjustments.
Enjoy seamless planning
With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.
Explore with confidence
From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.
Secure your spot
Confirm your package instantly and lock in the best rate with secure payment and guaranteed availability.
Get instant confirmation
Shortly after booking, you’ll receive your full itinerary, including schedules, locations, and everything you need for a stress-free trip.
Personalize your itinerary
Each package includes a professionally crafted itinerary you can tailor to your travel style. A dedicated travel expert will make sure every detail fits your needs perfectly.
Easily make changes
Need to update plans? No problem. Whether before your trip or mid-journey, we’re just seconds away to help with quick adjustments.
Enjoy seamless planning
With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.
Explore with confidence
From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.

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Your trip is protected, personalized, and priced right. No surprises, no stress.

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