6-Day Greece Self-Drive Road Trip With Itinerary from Thessaloniki traveling west to Larissa and Ioannina

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Escape the ordinary with this exciting 6-day road trip through Greece. Explore the diverse landscapes, lively cities, and beyond. Pack your bags, hit the road, and prepare for an unforgettable journey!

This perfectly planned road trip itinerary in Greece takes you through some of the best places to see in the country. You will spend 3 nights in Thessaloniki, 1 night in Larissa, and 1 night in Ioannina. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Greece. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have got you covered.

Upon arriving in Thessaloniki, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Greece on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Greece. White Tower Of Thessaloniki and Aristotelous Square are just a couple of the bucket-list attractions that await your discovery.

As you hit the open road and drive through Thessaloniki, Edessa, Larissa, Trikala, Kastraki, Ioannina, Perama, Neo Bizani, and Metsovo, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Greece. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Greece.

Throughout your road trip in Greece, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Greece.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodation, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in Greece fill up quickly, so book your spot early. Select a date and start planning your road trip in Greece today!

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Itinerary summary

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Days
Destination
Attractions
Overnight
Day
City & Overnight
Attractions
Aristotelous Square
The Umbrellas by ZongolopoulosArchaeological Museum of ThessalonikiWhite Tower of ThessalonikiHeptapyrgion of ThessalonicaAcropolis of Thessaloniki
KapaniAgias Sofias SquareCathedral of Agia Sophia ThessalonikiEdessa WaterfallsWhite Tower of Thessaloniki
Trikala City Center SquareMatsopoulos ParkThe Great Meteoron Holy Monastery of the Transfiguration of the SaviourMeteora
Ioannina CastleCave of PeramaVrellis Greek History Museum (Wax Museum)
Arch of GaleriusWhite Tower of Thessaloniki

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Day 1

Day 1 – Thessaloniki - arrival day

  • Thessaloniki - Arrival day
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  • Aristotelous Square
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Your road trip adventure in Greece begins as soon as you reach Thessaloniki and pick up your car. You’ll stay in Thessaloniki for 2 nights and explore the best things to see and do, sample the local cuisine, and choose from a curated selection of the best hotels and places to stay in the city.

Thessaloniki is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out Aristotelous Square or taking a stroll in the city center. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

Find your way to your hotel in Thessaloniki. We recommend choosing a hotel in a central location for easy exploring. Check-in typically starts between 2 and 4 PM at hotels in Greece. Settle in and make plans for the evening.

As dinnertime approaches, it's time to head out for a bite to eat in Thessaloniki. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.

Make sure to book a table at Kitchen Bar, a popular restaurant in Thessaloniki. This acclaimed restaurant and its mouthwatering dishes have earned the admiration of countless food lovers. Alternatively, experience a taste of Thessaloniki at The Greek, a popular local restaurant. With a menu designed to impress, it promises a journey of flavors that will leave you captivated. Another top-rated restaurant to try is Phanós. As a dining spot that gains high praise from guests, it’s an ideal choice to enhance your time to Thessaloniki tonight.

After enjoying a delightful dinner, why not delve into the vibrant local bar scene? You might want to spend the evening at Beetle Bar, a well-loved spot among locals and tourists. Or, head to Vogatsikou 3. This bar boasts a welcoming environment that is perfect for winding down. You could also continue your night at Souel, another top-rated place in the area.

Raise a toast to the start of your 6-day road trip in Greece!

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Day 2

Day 2 – Thessaloniki

  • Thessaloniki
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Drive 11 km, 56 min

  • The Umbrellas by Zongolopoulos
  • Archaeological Museum of Thessaloniki
  • White Tower of Thessaloniki
  • Heptapyrgion of Thessalonica
  • Acropolis of Thessaloniki
  • More

Day 2 of your road trip across Greece promises a magnificent time exploring Thessaloniki. You have 1 night left in Thessaloniki. Take the opportunity to experience more of the best attractions and activities in the city.

Just a short distance away is Archaeological Museum Of Thessaloniki, a respected museum that draws visitors from far and near.

Continue your journey to White Tower Of Thessaloniki, one of the city’s most astonishing spots that you shouldn’t miss. Another great site to visit is the often recommended Heptapyrgion Of Thessaloniki. Last up on today’s itinerary is a park. Make your way to Acropolis Of Thessaloniki for some final sightseeing. Each attraction will leave you with lasting memories and a deeper appreciation for the rich heritage of Thessaloniki.

Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Greece is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Thessaloniki. Enjoy a relaxing evening as you savor delicious local cuisine and reflect on the day's adventures.

Treat yourself to a delightful dinner at Mamalouka, highly recommended for tonight's dining. Or, if you're feeling adventurous, why not try Clochard? It's another excellent option with a diverse menu. Consider reserving a table at Sofi's House Restaurant as well. Known for its consistent customer satisfaction, it’s an ideal pick for tonight in Thessaloniki.

If you’re not ready to end the night just yet, Castra- All Day Terrace Bar offers a perfect venue to relax and savor a drink. Similarly, Barbaben - Bar/ba/ben is well-suited for those looking to unwind in a social setting. Apallou is another excellent spot to enjoy a nightcap after a delightful meal.

Relax and reminisce about your day in Greece and look forward to more memorable moments to come!

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Day 3

Day 3 – Thessaloniki, Edessa, and Larissa

  • Thessaloniki
  • Edessa
  • Thessaly and Central Greece
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Drive 280 km, 4 hours 7 min

  • Kapani
  • Agias Sofias Square
  • Cathedral of Agia Sophia Thessaloniki
  • Edessa Waterfalls
  • White Tower of Thessaloniki
  • More

Experience an unparalleled adventure on day 3 of your road trip in Greece. This exciting part of your journey invites you to discover the renowned landmarks in 2 vibrant destinations - Thessaloniki and Edessa. After a day filled with exploration and new experiences, you will retreat to the hotel of your choice in Larissa. You will spend 1 night here for some well-deserved relaxation.

A blend of a visually striking, a historically significant, a culturally significant, an awe-inspiring, a sacred, and an UNESCO world heritage-listed await you in Thessaloniki on today’s itinerary. First up is the notable market, Kapani. It's a standout spot that offers a memorable visit. Afterward, continue to Agias Sofias Square. A visit to this public square is an enriching experience for all.

As you explore Thessaloniki’s charming streets, take in the lively atmosphere and get to know the character of the city. Next, make your way to Holy Church Of Hagia Sophia. This curiosity-inducing church is an essential stop that should not be missed.

Fasten your seatbelt and make your way to your next stop. Edessa, home to many well-known sights in the region, is a lovely destination on today’s itinerary. Keep in mind that your travel time from Thessaloniki to Edessa may take around 1 hour 22 min without traffic disruptions. Upon arrival in Edessa, we highly recommend checking out some of the top attractions.

Savor the rest of your day by heading to Waterfalls Park, Edessa, a well-known waterfall that draws visitors from near and far.

When you’re done exploring for the day, you’ll drive to your hotel in Larissa. Check in and spend some time relaxing before you head out to tour the city.

After a day of adventure, treat yourself to an exquisite dinner at one of Larissa's best restaurants.

Have a fantastic dining experience at Nonna Rossa, a highly recommended choice for tonight's dinner. If you're looking to mix things up, Vosporos | Restaurant • Bar offers an enticing alternative with its varied menu. Additionally, THE ALLEY is worth considering. Renowned for satisfying diners, it’s an ideal option for tonight in Larissa.

After enjoying a delightful dinner, why not delve into the vibrant local bar scene? You might want to spend the evening at Sherlock Easy Bar, a well-loved spot among locals and tourists. Or, head to Kiou. This bar boasts a welcoming environment that is perfect for winding down. You could also continue your night at Wisedog, another top-rated place in the area.

Relax and reminisce about your day in Greece and look forward to more memorable moments to come!

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Day 4

Day 4 – Larissa, Trikala, Kastraki, and Ioannina

  • Thessaly and Central Greece
  • Trikala
  • Kastraki
  • Ioannina
  • More

Drive 199 km, 4 hours 9 min

  • Trikala City Center Square
  • Matsopoulos Park
  • The Great Meteoron Holy Monastery of the Transfiguration of the Saviour
  • Meteora
  • More

On day 4 of your exciting self-drive vacation in Greece, you’ll soak in the magnificence of 2 destinations, Trikala and Kastraki. When you’re not sightseeing, take time to relax at your selected hotel in Ioannina, where you’ll be staying for 1 night.

When you’re ready to jump back into the car and say goodbye to Larissa, you’ll hit the road in the direction of Trikala. This drive usually takes around 51 min. When you arrive, enjoy some sightseeing.

Your self-guided tour starts at Trikala City Center Square, an intriguing public square that is sure to impress. Take in the surroundings and enjoy the freedom of exploring before you continue your journey. Next, head to Matsopoulos Park and admire its enchanting features.

Once you're ready to continue your road trip, it's time to buckle up and drive, eagerly anticipating your arrival in Kastraki. This drive usually takes around 37 min, without any stops or traffic disruptions.

Head to Holy Monastery Of The Great Meteoron -transfiguration Of The Saviour, a frequently visited monastery in Kastraki. Explore its picture-perfect features at your own pace before you continue your journey to your next sight, Meteora. This popular monastery is a top recommendation in the area.

At the end of the day, you will drive to Ioannina, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

As dinnertime approaches, it's time to head out for a bite to eat in Ioannina. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.

Enjoy a lovely meal at To Dodeka Cafe Bar, a top-rated place to have dinner tonight. Alternatively, if your taste buds call for something different, Mustagogia is another top choice with a popular menu. You could also check for a table at Accademia Del Panino. As an establishment that gains consistently high praises from customers, it’s an ideal choice in Ioannina tonight.

Keep the evening going at ⚜ V E D E M A ⚜, a great choice for enjoying the after-dinner hours with a drink. You could also go to Hogwarts Tales And Spirits, which offers a similarly pleasant setting and great drinks. Another option is Chevalier, which provides an inviting environment for unwinding after a busy day out.

Get a good night's sleep and look forward to another great day on the road in Greece!

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Day 5

Day 5 – Ioannina, Perama, Neo Bizani, Metsovo, and Thessaloniki

  • Ioannina
  • Perama
  • Neo Bizani
  • Thessaloniki
  • More

Drive 292 km, 3 hours 51 min

  • Ioannina Castle
  • Cave of Perama
  • Vrellis Greek History Museum (Wax Museum)
  • More

Dive into day 5 of your remarkable road trip in Greece. Today you will explore Ioannina, Perama, Neo Bizani, and Metsovo, where you will have the opportunity to experience all the top things to see and do. At the end of the day, you’ll unwind at one of the finest accommodations in Thessaloniki. You’ll stay here for 1 night.

Today’s well-planned self-sightseeing route offers several a romantic, a breathtaking, an eye-catching, a respected, and a symbolic. Whether you decide to explore Ioannina on foot, use public transport, or join a guided tour, there are a few attractions you don’t want to miss. Ioannina Castle is the first of them. Spend some time admiring this visually striking castle before continuing your journey.

Embrace the thrill of the open road as you wave goodbye to Ioannina and set your GPS to Perama. While on the road, immerse yourself in your favorite road trip tunes or sample the sounds from a local radio station. This car ride usually takes around 9 min. Upon reaching Perama, unwind, observe, and explore. The best things to do, see, and eat are waiting for you.

Cave Of Perama is an often recommended cave we recommend making time to visit today. Discover its visually striking features before continuing your self-guided tour.

Neo Bizani’s wonders await as you prepare for another journey on the road, leaving the breathtaking surroundings of Perama behind. This drive usually takes around 30 min. Neo Bizani welcomes you with a multitude of unique vacation experiences.

Savor the rest of your day by heading to Moyseio Ellinikis Istorias Payloy Vrelli, an increasingly popular museum that draws visitors from near and far.

After soaking up all the sights of today's itinerary, you'll be ready to hit the road in the direction of your accommodation in Thessaloniki. Thessaloniki offers plenty of top-rated hotels and other places to stay on any travel budget. Take some time to relax before you head out to explore.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Thessaloniki. Enjoy a relaxing evening as you savor delicious local cuisine and reflect on the day's adventures.

Don’t miss out on dining at Enoches Bar, a top-rated dining destination in Thessaloniki. If you're in the mood to try something new, consider O Loytros, another top spot with a mouthwatering menu. You might also want to secure a reservation at rOOTS. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Thessaloniki this evening.

Continue your lively evening at Peiratis Cafe-bar, a perfect place for winding down or revving up the night, depending on which mood you’re in. In Rock Cafe Bar is another excellent bar that offers a great selection of drinks to suit any mood. If you prefer to go somewhere else, Tribeca ensures a night out tailored to your taste.

Take some time to reflect on your day and savor another beautiful night in Greece.

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Day 6

Day 6 – Thessaloniki - departure day

  • Thessaloniki - Departure day
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  • Arch of Galerius
  • White Tower of Thessaloniki
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Day 6 of your road trip in Greece is your departure day. This is your chance to catch a last glimpse of Thessaloniki before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

Make the most of your final day in Greece by visiting Thessaloniki’s iconic markets and shopping establishments. Secure the perfect souvenirs for your family and friends back home or buy yourself a remembrance of your amazing experience in Greece.

Whether you prefer a leisurely exploration or a more fast-paced adventure, this itinerary in Thessaloniki allows for both. Start by heading to Arch Of Galerius And Rotunda. This notable monument provides an insightful glimpse into the city's identity.

Before you conclude your road trip in Greece, drop by another restaurant for a last chance at a memorable dining experience in Thessaloniki.

You’ll then say farewell to Thessaloniki. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Greece!

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