6-Day Greece Self-Drive Road Trip With Itinerary from Thessaloniki traveling west to Kalambaka

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Photo of Saint Paul cathedral in Thessaloniki, Greece.
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Escape the ordinary with this exciting 6-day road trip through Greece. Explore diverse landscapes, discover lively cities, and prepare for an unforgettable journey!

This perfectly planned road trip itinerary takes you through some of the best places to see in Greece. You will spend 3 nights in Thessaloniki and 2 nights in Kalambaka. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Greece. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have you covered.

Upon arriving in Thessaloniki, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Greece on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Greece. White Tower Of Thessaloniki and Aristotelous Square are just a couple of the bucket-list attractions that await your discovery.

As you hit the open road and drive through Thessaloniki, Kalambaka, Kastraki, Trikala, Elassona, Dion, and Litochoro, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Greece. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Greece.

Throughout your road trip in Greece, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Greece.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodations, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in Greece fill up quickly, so book your spot early. Select a date and start planning your road trip in Greece today!

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Driver’s age is 30 - 65
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Pick-up: 10:00
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Day1

Day 1

  • Thessaloniki - Arrival day
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  • Ladadika
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Your road trip adventure in Greece begins as soon as you reach Thessaloniki and pick up your car. You’ll stay here for 2 nights and explore what to see in Thessaloniki, sample the local cuisine, and choose from a curated selection of the best hotels and places to stay in the city.

Thessaloniki is a beautiful city with plenty to discover. Taking a stroll in the city center is a great alternative. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

Find your way to your hotel in Thessaloniki. We recommend choosing a hotel in a central location for easy exploring. Check-in typically starts between 2 and 4 PM at hotels in Greece. Settle in and make plans for the evening.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Thessaloniki, it's often a good idea to reserve a table in advance.

Treat yourself to a delicious dinner at Kitchen Bar, an excellent option for tonight's dining. Looking for something different? The Greek offers a tantalizing alternative with its diverse menu. And don’t miss Phanós. Known for great service, it’s a fantastic choice for tonight in Thessaloniki.

After your meal, keep the night alive at a bar like Beetle Bar, known for its lively atmosphere. Vogatsikou 3 is another top recommendation that provides the perfect setting with well-crafted drinks and a welcoming ambiance. Similarly, Souel offers an excellent atmosphere for those looking to amp up the evening.

Raise a toast to the start of your 6-day road trip in Greece!

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Day2

Day 2

  • Thessaloniki
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Drive 6 km, 53 min

  • Kapani
  • Aristotelous Square
  • Agias Sofias Square
  • Arch of Galerius
  • White Tower of Thessaloniki
  • Tsimiski Street
  • More

On day 2 of your road trip, you will have an entire day to discover what to see in Thessaloniki. You’ll stay in Thessaloniki for 1 night.

Thessaloniki is brimming with adventures. Tsimiski Street is a street that stands out as one of the must-see places in Thessaloniki. Take a moment to explore its distinct atmosphere, and don’t miss the popular sightseeing spots just a short walk away.

Awaiting your discovery is the popular Kapani, a heritage-rich market in Thessaloniki. Next, go to Aristotelous Square.

After visiting Kapani and Aristotelous Square, have a stroll along Thessaloniki's streets and take in the local charm. Continue your sightseeing by heading to Agias Sofias Square. This photogenic public square offers a unique experience. Arch Of Galerius And Rotunda is another noteworthy attraction worthwhile a visit. End your self-guided sightseeing tour on top with a visit to White Tower Of Thessaloniki, one of the most picture-perfect places to visit in Thessaloniki.

Don’t forget to check out all the popular tours and experiences you can add to your travel plans in Greece. You can explore and select activities under each day of your itinerary.

Indulge in a memorable dining experience at one of Thessaloniki's most popular restaurants, and connect with friendly locals for a true cultural experience.

Savor the flavors at Mamalouka, a top pick for dinner tonight. Alternatively, Clochard beckons with its unique menu offerings. Also, consider Sofi's House Restaurant. With its consistent customer satisfaction, it’s an excellent option for dining in Thessaloniki tonight.

Keep the evening going at Castra- All Day Terrace Bar, a great choice for enjoying the after-dinner hours with a drink. You could also go to Barbaben - Bar/ba/ben, which offers a similarly pleasant setting and great drinks. Another option is Apallou, which provides an inviting environment for unwinding after a busy day out.

Relax and look forward to more memorable moments to come!

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Day3

Day 3

  • Thessaloniki
  • Meteora
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Drive 246 km, 3 hours 25 min

  • Monastery of St Stephan
  • Meteora
  • Natural History Museum of Meteora and Mushroom Museum
  • Greek Education Museum
  • More

On day 3 of your road trip in Greece, your travel plans include 2 stops at the most scenic, wondrous, and interesting places in the region. Kalambaka and Kastraki are on today's agenda. In the evening, you’ll end up in Kalambaka, where you will stay for 2 nights.

Look forward to a unique sightseeing adventure at the curiosity-inducing Holy Monastery Of Saint Stephan and allow yourself time to explore. Just a short distance away you'll find your next stop, Meteora, a picturesque monastery that draws visitors from far and near.

Continue your journey to Natural History Museum Of Meteora And Mushroom Museum, one of the town’s most up-and-coming spots that you shouldn’t miss. Another great site to visit is the beloved Greek Education Museum.

After soaking up all the sights on today's itinerary, you'll be ready to head to your accommodation in Kalambaka. Kalambaka offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Kalambaka, it's often a good idea to reserve a table in advance.

Celebrate another amazing day of your road trip adventure in Greece!

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Day4

Day 4

  • Meteora
  • More

Drive 58 km, 1 hour 48 min

  • The Great Meteoron Holy Monastery of the Transfiguration of the Saviour
  • Monastery of Varlaam
  • Main Observation Deck of Meteora
  • Trikala City Center Square
  • Central Bridge
  • Matsopoulos Park
  • More

Wake up to day 4 of your road trip in Greece. On this day, you’ll embark on an exciting expedition discovering the enchanting sights and activities of Kastraki and Trikala. With 1 night to stay in Kalambaka, we encourage you to seize the day and discover the unexplored beauty of the town’s surroundings!

Look forward to a unique sightseeing adventure at the frequently visited Holy Monastery Of The Great Meteoron -transfiguration Of The Saviour and allow yourself time to explore. Just a short distance away you'll find your next stop, Monastery Of Varlaam, a historic monastery that draws visitors from far and near.

Continue your journey to Main Observation Deck Of Meteora, one of the village’s most worthwhile spots that you shouldn’t miss. Another great site to visit is the often recommended Trikala City Center Square. When you're finished at the public square, Central Bridge awaits your visit. This public square is a history-steeped highlight on today's itinerary. Last up is a park - the curiosity-inducing Matsopoulos Park.

When you’re done exploring the area’s best attractions, you’ll drive back to your accommodation in Kalambaka.

After a day of adventure, treat yourself to an exquisite dinner at one of Kalambaka's best restaurants.

Savor another day of unforgettable experiences in Greece!

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Day5

Day 5

  • Meteora
  • Thessaloniki
  • More

Drive 270 km, 4 hours 6 min

  • Kanalon Monastery
  • Archaeological Site of Dion
  • Archaeological Museum of Dion
  • Litochoro Center
  • More

Experience an unparalleled adventure on day 5 of your road trip in Greece. This exciting part of your journey invites you to discover the renowned landmarks in 3 places, which are Elassona, Dion, and Litochoro. At the end of the day, you will retreat to the hotel of your choice in Thessaloniki, where will spend 1 night.

Kanalon Monastery is must-visit monastery and a great option for a daytime tour of the area. Continue your journey to Archaeological Park Of Dion, an increasingly popular archeological site, located just a leisurely stroll away. Next, head to Archaeological Museum Of Dion, a respected museum, also available for your discovery today.

At the end of the day, you will drive to Thessaloniki, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

Indulge in a memorable dining experience at one of Thessaloniki's most popular restaurants, and connect with friendly locals for a true cultural experience.

Treat yourself to a delicious dinner at Enoches Bar, an excellent option for tonight's dining. Looking for something different? O Loytros offers a tantalizing alternative with its diverse menu. And don’t miss rOOTS. Known for great service, it’s a fantastic choice for tonight in Thessaloniki.

Keep the excitement of the evening going by visiting a bar or two. Peiratis Cafe-bar is an excellent place to start. You could also check out In Rock Cafe Bar, offering a different kind of charm. A last recommendation for the day is Tribeca. This bar promises an enjoyable experience with tasty drinks and a vibrant setting.

Raise your glass to another unforgettable day in Greece!

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Day6

Day 6

  • Thessaloniki - Departure day
  • More
  • The Umbrellas by Zongolopoulos
  • More

Day 6 of your road trip in Greece is your departure day. This is your chance to catch a last glimpse of Thessaloniki before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

If you're up for some more sightseeing, begin at The Umbrellas Sculpture By Zogolopoulos. This popular art installation is a hotspot among locals.

For a last-minute shopping spree in Thessaloniki, Tsimiski Street is nearby. Enjoy a variety of retail stores, dining options, and essential services in one convenient location. Browse through boutiques to find unique and stylish fashion pieces to take home.

Before you conclude your road trip in Greece, drop by another restaurant for a last chance at a memorable dining experience in Thessaloniki.

If you're in the mood to try something new, consider Agora Ouzeri, another top spot with a mouthwatering menu.

You’ll then say farewell to Thessaloniki. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Greece!

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Shortly after booking, you’ll receive your full itinerary, including schedules, locations, and everything you need for a stress-free trip.
Personalize your itinerary
Each package includes a professionally crafted itinerary you can tailor to your travel style. A dedicated travel expert will make sure every detail fits your needs perfectly.
Easily make changes
Need to update plans? No problem. Whether before your trip or mid-journey, we’re just seconds away to help with quick adjustments.
Enjoy seamless planning
With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.
Explore with confidence
From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.
Secure your spot
Confirm your package instantly and lock in the best rate with secure payment and guaranteed availability.
Get instant confirmation
Shortly after booking, you’ll receive your full itinerary, including schedules, locations, and everything you need for a stress-free trip.
Personalize your itinerary
Each package includes a professionally crafted itinerary you can tailor to your travel style. A dedicated travel expert will make sure every detail fits your needs perfectly.
Easily make changes
Need to update plans? No problem. Whether before your trip or mid-journey, we’re just seconds away to help with quick adjustments.
Enjoy seamless planning
With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.
Explore with confidence
From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.

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Your trip is protected, personalized, and priced right. No surprises, no stress.

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