7-Day Greece Self-Drive Road Trip With Itinerary from Ioannina traveling east to Kalambaka and Thessaloniki

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Photo of Plakidas Bridge in Ioannina in Greece by DanaTentis
Photo of Ioannina lake Pamvotida in Epirus Region, Greece.
7-Day Greece Self-Drive Road Trip With Itinerary from Ioannina traveling east to Kalambaka and Thessaloniki
7-Day Greece Self-Drive Road Trip With Itinerary from Ioannina traveling east to Kalambaka and Thessaloniki
7-Day Greece Self-Drive Road Trip With Itinerary from Ioannina traveling east to Kalambaka and Thessaloniki
7-Day Greece Self-Drive Road Trip With Itinerary from Ioannina traveling east to Kalambaka and Thessaloniki
7-Day Greece Self-Drive Road Trip With Itinerary from Ioannina traveling east to Kalambaka and Thessaloniki
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Experience the freedom of the open road on an unforgettable 7-day road trip in Greece! Embark on a self-drive tour that caters to every traveler, featuring destinations like Ioannina, Perama, Kalambaka, Kastraki, Thessaloniki, Mandio, and Neo Bizani.

This perfectly planned road trip itinerary takes you through some of the best places to see in Greece. You will spend 3 nights in Ioannina, 2 nights in Kalambaka, and 1 night in Thessaloniki. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Greece. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have you covered.

Upon arriving in Ioannina, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Greece on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Greece. White Tower Of Thessaloniki and Aristotelous Square are just a couple of the bucket-list attractions that await your discovery.

As you hit the open road and drive through Ioannina, Perama, Kalambaka, Kastraki, Thessaloniki, Mandio, and Neo Bizani, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Greece. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Greece.

Throughout your road trip in Greece, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Greece.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodations, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in Greece fill up quickly, so book your spot early. Select a date and start planning your road trip in Greece today!

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Driver’s age is 30 - 65
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Day1

Day 1

  • Ioannina - Arrival day
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  • Ioannina Castle
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Welcome to Ioannina, the perfect starting point for your road trip in Greece! Pick up your rental car and let the adventure begin. You will spend 2 nights discovering what to see in Ioannina before embarking on the next leg of your journey.

Ioannina is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out Ioannina Castle. Taking a stroll in the city center is a great alternative. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

When you're ready for some downtime, make your way to your chosen hotel. Check-in typically starts between 2 and 4 PM in Ioannina. Make yourself at home and unwind before heading out again.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Ioannina, it's often a good idea to reserve a table in advance.

Make sure to reserve a table at To Dodeka Cafe Bar, an iconic dining spot in Ioannina. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Mustagogia, a popular restaurant in Ioannina. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of Accademia Del Panino, a hidden gem nestled in Ioannina. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

Cap off your dinner by heading to ⚜ V E D E M A ⚜, ideal for a leisurely evening with a drink in hand. Hogwarts Tales And Spirits is another bar that offers an enjoyable setting. Similarly, Chevalier is also a popular place to go on a night out, perfect for relaxing and socializing.

Raise a toast to the start of your 7-day road trip in Greece!

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Day2

Day 2

  • Ioannina
  • Perama
  • More

Drive 11 km, 38 min

  • Cave of Perama
  • Museum "Arslan Pasha"
  • Ich Kale Acropolis of Ioannina
  • Fethiye Mosque
  • Byzantine Museum of Ioannina
  • Silversmithing Museum
  • More

On day 2 of your road trip, you’ll start and end your day in Ioannina, where you still have 1 night left. You'll spend part of the day exploring places of interest outside the immediate city, including Perama and Ioannina.

Next, go to Ic Kale Acropolis Of Ioannina.

After visiting Museum "arslan Pasha" and Ic Kale Acropolis Of Ioannina, have a stroll along Ioannina's streets and take in the local charm. Continue your sightseeing by heading to Fethiye Mosque. This grand mosque offers a unique experience. Byzantine Museum Of Ioannina is another noteworthy attraction worthwhile a visit. End your self-guided sightseeing tour on top with a visit to Silversmithing Museum Of Ioannina, one of the most heritage-rich places to visit in Ioannina.

Embrace the thrill of the open road as you wave goodbye to Ioannina and set your GPS to Perama. While on the road, immerse yourself in your favorite road trip tunes or sample the sounds from a local radio station. This car ride usually takes around 10 min. Upon reaching Perama, unwind, observe, and explore. The best things to do, see, and eat are waiting for you.

Enjoy sightseeing at your own pace and allow yourself time to explore the beautiful surroundings. Take your self-guided tour to Cave Of Perama, a locally appreciated cave that everyone visiting Perama should see.

When you’re done exploring the area’s best attractions, you’ll drive back to your accommodation in Ioannina.

Indulge in a memorable dining experience at one of Ioannina's most popular restaurants, and connect with friendly locals for a true cultural experience.

Have a fantastic dining experience at Spitaki me thea, a highly recommended choice for tonight's dinner. If you're looking to mix things up, Frontzoy Politeia - Frontzu Politia Restaurant offers an enticing alternative with its varied menu. Additionally, Papi Cafe Bistro is worth considering. Renowned for satisfying diners, it’s an ideal option for tonight in Ioannina.

If you’re not ready to end the night just yet, Scala offers a perfect venue to relax and savor a drink. Similarly, Route 66 Bar is well-suited for those looking to unwind in a social setting. Palia Agora is another excellent spot to enjoy a nightcap after a delightful meal.

Head back to your accommodation in Ioannina and get some rest to prepare for another magical day of your road trip in Greece.

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Day3

Day 3

  • Ioannina
  • Meteora
  • Kastraki
  • More

Drive 122 km, 2 hours 27 min

  • Meteora Digital Projection Center
  • Monastery of St Stephan
  • Meteora
  • Natural History Museum of Meteora and Mushroom Museum
  • Greek Education Museum
  • More

Dive into day 3 of your remarkable road trip in Greece. Today you'll explore 2 destinations, including Kalambaka and Kastraki. At the end of the day, you’ll unwind at one of the finest accommodations in Kalambaka, where you'll spend 2 nights.

Fasten your seatbelt and make your way to your next stop — Kalambaka, home to many well-known sights in the region. Keep in mind that your travel time from Ioannina to Kalambaka may take around 1 hour 40 min without traffic disruptions. Upon arrival in Kalambaka, we highly recommend checking out some of the top attractions.

One of our top recommendations for your sightseeing is Meteora Digital Projection Center. Then, head to Holy Monastery Of Saint Stephan. This intriguing monastery is a traveler-favorite in the town.

If you're keen to see more, continue to Natural History Museum Of Meteora And Mushroom Museum. Feed your curiosity by learning something new about the museum. Next, take your journey to Greek Education Museum, a curiosity-inducing museum.

It’s time to gear up for the next part of your road trip adventure. Upon your arrival in Kastraki, you’ll be greeted with the opportunity to do some sightseeing and exploring.

Spend your afternoon discovering Meteora, a well-known monastery known for its idyllic features.

At the end of the day, you will drive to Kalambaka, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Kalambaka, it's often a good idea to reserve a table in advance.

Relax and look forward to more memorable moments to come!

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Day4

Day 4

  • Meteora
  • Kastraki
  • More

Drive 16 km, 43 min

  • The Great Meteoron Holy Monastery of the Transfiguration of the Saviour
  • Monastery of Varlaam
  • Main Observation Deck of Meteora
  • More

On day 4 of your road trip in Greece, you’ll start and end your day in Kalambaka, but spend the day exploring what’s beyond the town. Since you still have 1 night to spend in Kalambaka, there’s no need to rush. Experience Kastraki to the fullest today with this curated day itinerary.

When you’ve had your share of Kalambaka, prepare for your next destination. Admire the views and listen to some good music as you drive in the direction of Kastraki. Your travel time is around 15 min.

Set out on a self-guided sightseeing tour at Holy Monastery Of The Great Meteoron -transfiguration Of The Saviour and explore the UNESCO world heritage-designated features. Next, make your way to Monastery Of Varlaam, another highlight in Kastraki. When you’re done exploring the monastery, continue to Main Observation Deck Of Meteora, an UNESCO world heritage-designated observation deck.

When you’re done exploring for the day, you’ll return to Kalambaka and your accommodation.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Kalambaka, it's often a good idea to reserve a table in advance.

Savor another day of unforgettable experiences in Greece!

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Day5

Day 5

  • Meteora
  • Thessaloniki
  • More

Drive 240 km, 3 hours 42 min

  • White Tower of Thessaloniki
  • Archaeological Museum of Thessaloniki
  • Arch of Galerius
  • Church of St Demetrios
  • Aristotelous Square
  • More

Experience an unparalleled adventure on day 5 of your road trip in Greece. This exciting part of your journey invites you to discover the renowned landmarks in 1 place, which are Thessaloniki. At the end of the day, you will retreat to the hotel of your choice in Thessaloniki, where will spend 1 night.

When you’ve had your share of Kalambaka, prepare for your next destination. Admire the views and listen to some good music as you drive in the direction of Thessaloniki. Your travel time is around 2 hours 43 min.

Enjoy sightseeing at your own pace and allow yourself time to explore the beautiful surroundings. Take your self-guided tour to White Tower Of Thessaloniki, a famous monument that everyone visiting Thessaloniki should see. Next, head to Archaeological Museum Of Thessaloniki. This respected museum is one of the most beloved attractions in the region.

If you're keen to see more, don’t miss out on Arch Of Galerius And Rotunda, an instagrammable monument popular among locals as well as travelers. Holy Church Of Saint Demetrius, Patron Saint Of Thessalonica is an excellent attraction to visit next. Spend some time learning more about this underrated church before you continue your journey. Lastly, visit Aristotelous Square, a visually striking public square and a top attraction in the city.

After soaking up all the sights on today's itinerary, you'll be ready to head to your accommodation in Thessaloniki. Thessaloniki offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

Thessaloniki is a place where the culinary landscape is as diverse as its attractions. So before the day ends, treat your palate to a taste of local cuisine at one of the best restaurants in Thessaloniki.

Treat yourself to a delicious dinner at Kitchen Bar, an excellent option for tonight's dining. Looking for something different? The Greek offers a tantalizing alternative with its diverse menu. And don’t miss Phanós. Known for great service, it’s a fantastic choice for tonight in Thessaloniki.

After your meal, keep the night alive at a bar like Beetle Bar, known for its lively atmosphere. Vogatsikou 3 is another top recommendation that provides the perfect setting with well-crafted drinks and a welcoming ambiance. Similarly, Souel offers an excellent atmosphere for those looking to amp up the evening.

Raise your glass to another unforgettable day in Greece!

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Day6

Day 6

  • Thessaloniki
  • Mandio
  • Neo Bizani
  • Ioannina
  • More

Drive 293 km, 3 hours 23 min

  • Archaeological Site of Dodoni
  • Vrellis Greek History Museum (Wax Museum)
  • More

On day 6 of your exciting self-drive vacation in Greece, you’ll soak in the magnificence of 2 destinations, including Mandio and Neo Bizani. When you’re not sightseeing, take time to relax at your chosen hotel in Ioannina, where you’ll be staying for 1 night.

Continue your road trip and head to your next destination, Mandio. This car ride takes around 2 hours 44 min.

Savor the day by heading to Archaeological Site Of Dodoni, a curiosity-inducing archeological site that draws visitors from near and far.

Continue your road trip and head to your next destination, Neo Bizani. This car ride takes around 17 min.

Savor the day by heading to Moyseio Ellinikis Istorias Payloy Vrelli, an up-and-coming museum that draws visitors from near and far.

When you’re done exploring for the day, you’ll drive to your hotel in Ioannina. Check in and relax before you head out to tour the city.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Ioannina. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Don’t miss out on dining at PRESVEIA Restaurant Meze, a top-rated dining destination in Ioannina. If you're in the mood to try something new, consider Frontzu Politia - Hotel, another top spot with a mouthwatering menu. You might also want to secure a reservation at Equus. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Ioannina this evening.

After savoring a delicious meal, step into the vibrant nightlife at Spitaki, where the evening is just getting started. In the same way, American Bar offers a unique charm perfect for experiencing the local bar scene in Ioannina. Olympic is another top-recommended bar that is sure to get you into the mood for some dancing and celebrating.

Take some time to reflect on your day and savor another beautiful night in Greece.

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Day7

Day 7

  • Ioannina - Departure day
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  • The Clock Tower of Ioannina
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Day 7 of your road trip in Greece is your departure day. This is your chance to catch a last glimpse of Ioannina before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

If you're up for some more sightseeing, begin at The Clock Tower Of Ioannina. This curiosity-inducing monument is a hotspot among locals.

Take advantage of your accommodation's proximity to Ioannina’s shopping district for some last-minute bargain hunting. Explore local shops for souvenirs to remember your trip or find unique gifts for loved ones. Discover boutiques offering an array of stylish fashion choices. Take a break with a cup of coffee or tea while savoring the local vibe in a coffee shop.

Before you conclude your road trip in Greece, drop by another restaurant for a last chance at a memorable dining experience in Ioannina.

If you're in the mood to try something new, consider Motley Coffeesweet, another top spot with a mouthwatering menu.

You’ll then say farewell to Ioannina. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Greece!

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Enjoy seamless planning
With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.
Explore with confidence
From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.
Secure your spot
Confirm your package instantly and lock in the best rate with secure payment and guaranteed availability.
Get instant confirmation
Shortly after booking, you’ll receive your full itinerary, including schedules, locations, and everything you need for a stress-free trip.
Personalize your itinerary
Each package includes a professionally crafted itinerary you can tailor to your travel style. A dedicated travel expert will make sure every detail fits your needs perfectly.
Easily make changes
Need to update plans? No problem. Whether before your trip or mid-journey, we’re just seconds away to help with quick adjustments.
Enjoy seamless planning
With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.
Explore with confidence
From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.

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