7-Day Greece Self-Drive Road Trip With Itinerary from Thessaloniki to Kalambaka, Ioannina, and Metsovo

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Photo of Saint Paul cathedral in Thessaloniki, Greece.
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Explore the best of Greece on a remarkable 7-day road trip! Combine exploration with relaxation on a self-drive tour featuring Thessaloniki, Kastraki, Kalambaka, Perama, Ioannina, Anilio, Metsovo, and Vergina.

This perfectly planned road trip itinerary takes you through some of the best places to see in Greece. You will spend 3 nights in Thessaloniki, 1 night in Kalambaka, 1 night in Ioannina, and 1 night in Metsovo. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Greece. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have you covered.

Upon arriving in Thessaloniki, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Greece on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Greece. White Tower Of Thessaloniki and Aristotelous Square are just a couple of the bucket-list attractions that await your discovery.

As you hit the open road and drive through Thessaloniki, Kastraki, Kalambaka, Perama, Ioannina, Anilio, Metsovo, and Vergina, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Greece. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Greece.

Throughout your road trip in Greece, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Greece.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodations, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in Greece fill up quickly, so book your spot early. Select a date and start planning your road trip in Greece today!

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Driver’s age is 30 - 65
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Day1

Day 1

  • Thessaloniki - Arrival day
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  • Ladadika
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Welcome to Thessaloniki, the perfect starting point for your road trip in Greece! Pick up your rental car and let the adventure begin. You will spend 2 nights discovering what to see in Thessaloniki before embarking on the next leg of your journey.

Thessaloniki is a beautiful city with plenty to discover. Taking a stroll in the city center is a great alternative. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

When you're ready for some downtime, make your way to your chosen hotel. Check-in typically starts between 2 and 4 PM in Thessaloniki. Make yourself at home and unwind before heading out again.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Thessaloniki, it's often a good idea to reserve a table in advance.

Treat yourself to a delicious dinner at Kitchen Bar, an excellent option for tonight's dining. Looking for something different? The Greek offers a tantalizing alternative with its diverse menu. And don’t miss Phanós. Known for great service, it’s a fantastic choice for tonight in Thessaloniki.

Extend your evening after a delightful meal by visiting Beetle Bar, which offers the perfect atmosphere for a night out. Moreover, Vogatsikou 3 is another popular option for a drink or two. Likewise, Souel also provides a great ambiance for reminiscing about the day and raising a toast to your vacation.

Raise a toast to the start of your 7-day road trip in Greece!

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Day2

Day 2

  • Thessaloniki
  • More

Drive 6 km, 59 min

  • The Umbrellas by Zongolopoulos
  • Museum of Byzantine Civilization
  • Archaeological Museum of Thessaloniki
  • White Tower of Thessaloniki
  • Aristotelous Square
  • Tsimiski Street
  • More

Day 2 offers an itinerary packed with the best things to see in Thessaloniki. You’ll stay in Thessaloniki for 1 night more, offering you enough time to explore at a relaxed pace.

One of the most iconic spots you can visit today is Tsimiski Street. Allow yourself some time to explore this street and discover its unique quirks. You'll also find many of the best sightseeing spots nearby.

Make time for The Umbrellas Sculpture By Zogolopoulos, a popular art installation that is worthwhile a visit in the city. Nearby, you’ll find Museum Of Byzantine Culture, enchanting visitors with its photogenic appeal. Continue your exploration at Archaeological Museum Of Thessaloniki. This museum is one of the city’s most intriguing spots.

Enjoy the freedom of exploring Thessaloniki at your own pace and find hidden gems along the way. If you want to see more picture-perfect spots, make sure to visit White Tower Of Thessaloniki. After exploring the monument, head to the interesting Aristotelous Square.

Don’t forget to check out all the popular tours and experiences you can add to your travel plans in Greece. You can explore and select activities under each day of your itinerary.

After a day of adventure, treat yourself to an exquisite dinner at one of Thessaloniki's best restaurants.

Treat yourself to a wonderful meal at Mamalouka, a top-rated dining spot in Thessaloniki. If you're in the mood for something new, try Clochard, another premier location with a delectable menu. You might also want to book a table at Sofi's House Restaurant. Known for its consistently satisfied patrons, it’s a perfect choice to elevate your evening in Thessaloniki.

After savoring a delicious meal, step into the vibrant nightlife at Castra- All Day Terrace Bar, where the evening is just getting started. In the same way, Barbaben - Bar/ba/ben offers a unique charm perfect for experiencing the local bar scene in Thessaloniki. Apallou is another top-recommended bar that is sure to get you into the mood for some dancing and celebrating.

As the sun sets, rest up and recharge for the next leg of your road trip in Greece.

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Day3

Day 3

  • Thessaloniki
  • Kastraki
  • Meteora
  • More

Drive 240 km, 3 hours 33 min

  • The Great Meteoron Holy Monastery of the Transfiguration of the Saviour
  • Monastery of Varlaam
  • Main Observation Deck of Meteora
  • Natural History Museum of Meteora and Mushroom Museum
  • Greek Education Museum
  • More

Dive into day 3 of your remarkable road trip in Greece. Today you'll explore 2 destinations, including Kastraki and Kalambaka. At the end of the day, you’ll unwind at one of the finest accommodations in Kalambaka, where you'll spend 1 night.

Kastraki’s wonders await as you prepare for another journey on the road, leaving the breathtaking surroundings of Thessaloniki behind. This drive usually takes around 2 hours 53 min. Kastraki welcomes you with a multitude of unique vacation experiences.

Spend your afternoon discovering Holy Monastery Of The Great Meteoron -transfiguration Of The Saviour, an up-and-coming monastery known for its breathtaking features. Next, continue your sightseeing at Monastery Of Varlaam, a worthwhile monastery.

If you're starting to feel hungry, this is a great time for a break at a nearby restaurant or cafe. When you're ready for more, stop by Main Observation Deck Of Meteora and uncover the details of this standout observation deck.

When you’ve had your share of Kastraki, prepare for your next destination. Admire the views and listen to some good music as you drive in the direction of Kalambaka. Your travel time is around 11 min.

Natural History Museum Of Meteora And Mushroom Museum is a beloved museum we recommend visiting today. Discover its photogenic features before continuing your self-guided tour to Greek Education Museum, an instagrammable museum that’s well-regarded in the area.

When you’re done exploring for the day, you’ll drive to your hotel in Kalambaka. Check in and relax before you head out to tour the town.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Kalambaka. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Celebrate another amazing day of your road trip adventure in Greece!

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Day4

Day 4

  • Meteora
  • Perama
  • Ioannina
  • More

Drive 107 km, 2 hours 26 min

  • Cave of Perama
  • Silversmithing Museum
  • Ich Kale Acropolis of Ioannina
  • Ioannina Castle
  • Litharitsia park
  • The Clock Tower of Ioannina
  • More

On day 4 of your exciting self-drive vacation in Greece, you’ll soak in the magnificence of 2 destinations, including Perama and Ioannina. When you’re not sightseeing, take time to relax at your chosen hotel in Ioannina, where you’ll be staying for 1 night.

After soaking in Kalambaka’s unique atmosphere, jump into the car with a full heart and drive in the direction of your next destination: Perama. Expect your car journey to take a minimum of 1 hour 42 min. When you arrive in Perama, it's time to take a break from the road.

Our first attraction recommendation in Perama is Cave Of Perama, a curiosity-inducing cave that draws attention for its stunning features.

Ioannina’s wonders await as you prepare for another journey on the road, leaving the breathtaking surroundings of Perama behind. This drive usually takes around 12 min. Ioannina welcomes you with a multitude of unique vacation experiences.

For a more meaningful self-guided tour of the town's best attractions, visit Silversmithing Museum Of Ioannina, an increasingly popular museum that is sure to impress. Take in the surroundings and enjoy the freedom of exploring at your own pace before you continue your journey. Next, head to Ic Kale Acropolis Of Ioannina and admire its standout features.

When you’re ready, continue to Ioannina Castle, a locally renowned castle beloved by locals and tourists alike. Don't miss out on Litharitsia Park, another highlight of the area that promises a memorable visit. Not far away, you’ll also find The Clock Tower Of Ioannina, a culturally significant place to see that you won’t regret spending some extra time discovering.

At the end of the day, you will drive to Ioannina, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Ioannina. Enjoy a relaxing evening as you savor delicious local cuisine.

Enjoy a delicious meal at To Dodeka Cafe Bar, a top-rated dining destination in Ioannina. If you're in the mood to try something new, consider Mustagogia, another top spot with a mouthwatering menu. You might also want to secure a reservation at Accademia Del Panino. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Ioannina this evening.

Unwind after your meal by stepping into ⚜ V E D E M A ⚜. This venue is celebrated for its extensive drink selections and cozy vibes. Alternatively, Hogwarts Tales And Spirits offers a dynamic and energetic atmosphere for a glass or two. Don’t overlook Chevalier, another top-rated bar in the area.

Relax and look forward to more memorable moments to come!

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Day5

Day 5

  • Ioannina
  • Anilio
  • Metsovo
  • More

Drive 56 km, 1 hour 15 min

  • Καταρράκτης Ανήλιου
  • Αβερώφειος Κήπος
  • Metsovo Folk Art Museum (Tossizza Mansion)
  • Metsovo square
  • Averoff Art Gallery
  • More

On day 5 of your road trip in Greece, your travel plans include 2 stops at the most scenic, wondrous, and interesting places in the region. Anilio and Metsovo are on today's agenda. In the evening, you’ll end up in Metsovo, where you will stay for 1 night.

Embrace the thrill of the open road as you wave goodbye to Ioannina and set your GPS to Anilio. While on the road, immerse yourself in your favorite road trip tunes or sample the sounds from a local radio station. This car ride usually takes around 44 min. Upon reaching Anilio, unwind, observe, and explore. The best things to do, see, and eat are waiting for you.

For a more meaningful self-guided tour of the village's best attractions, visit Katarraktis Anilioy, a curiosity-inducing waterfall that is sure to impress. Take in the surroundings and enjoy the freedom of exploring at your own pace before you continue your journey.

Once you're ready to continue your road trip, it's time to buckle up and drive, eagerly anticipating your arrival in Metsovo. This drive usually takes around 11 min, without any stops or traffic disruptions.

Set out on a self-guided sightseeing tour at Averofeios Kipos and explore the serene features. Next, make your way to Metsovo Folk Art Museum (tossizza Mansion), another highlight in Metsovo. When you’re done exploring the museum, continue to Metsovo Square, an awe-inspiring public square.

Nearby, you will also find Averoff Art Gallery. This worthwhile art gallery is a top place to see in the area.

After soaking up all the sights on today's itinerary, you'll be ready to head to your accommodation in Metsovo. Metsovo offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

Indulge in a memorable dining experience at one of Metsovo's most popular restaurants, and connect with friendly locals for a true cultural experience.

Enjoy a lovely dining experience at Ta 5 FFFFF, a popular restaurant in Metsovo. This acclaimed establishment has earned the admiration of countless food lovers in the city. Alternatively, experience a taste of Metsovo at Cafe Petrino, another great place to eat. With a menu designed to impress, it promises a journey of flavors that will leave you captivated. A third option to check out is the top-rated Fame Metsovo. It’s yet another ideal choice to enhance your time in Metsovo tonight.

After enjoying a fulfilling meal, continue your evening at Karma, ideal for those looking to unwind with a drink in a comfortable setting. Alternatively, Krini Cafe Metsovo offers a welcoming atmosphere for easing into the nightlife. Similarly, Stul Cafe provides an excellent environment for a relaxed and enjoyable evening.

Take some time to reflect on your day and savor another beautiful night in Greece.

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Day6

Day 6

  • Metsovo
  • Vergina
  • Thessaloniki
  • More

Drive 236 km, 2 hours 41 min

  • Polycentric Museum of Aigai (Aegae) - Main Building
  • Museum of the Royal Tombs at Aigai (Aegae)
  • More

Your itinerary for day 6 of your road trip in Greece includes 1 stop and features some of the highlights of Vergina. At the end of the day, enjoy the comforts of a top-rated hotel in Thessaloniki, where you'll spend 1 night.

When you’ve had your share of Metsovo, prepare for your next destination. Admire the views and listen to some good music as you drive in the direction of Vergina. Your travel time is around 1 hour 42 min.

Enjoy sightseeing at your own pace and allow yourself time to explore the beautiful surroundings. Take your self-guided tour to Polycentric Museum Of Aigai (aegae) - Main Building, an intriguing museum that everyone visiting Vergina should see. Next, head to Museum Of The Royal Tombs At Aigai (aegae). This heritage-rich museum is one of the most curiosity-inducing attractions in the region.

When you’re done exploring for the day, you’ll drive to your hotel in Thessaloniki. Check in and relax before you head out to tour the city.

After a day of adventure, treat yourself to an exquisite dinner at one of Thessaloniki's best restaurants.

Treat yourself to a delicious dinner at Enoches Bar, an excellent option for tonight's dining. Looking for something different? O Loytros offers a tantalizing alternative with its diverse menu. And don’t miss rOOTS. Known for great service, it’s a fantastic choice for tonight in Thessaloniki.

To truly maximize your evening out, consider visiting Peiratis Cafe-bar after dinner. This bar is known for offering some of the best drinks and vibes in the city. Alternatively, head to In Rock Cafe Bar, another bar with an inviting ambiance. Similarly, Tribeca also offers a great atmosphere, ensuring a night filled with enjoyment and relaxation.

Head back to your accommodation in Thessaloniki and get some rest to prepare for another magical day of your road trip in Greece.

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Day7

Day 7

  • Thessaloniki - Departure day
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  • Arch of Galerius
  • More

Day 7 of your road trip in Greece is your departure day. This is your chance to catch a last glimpse of Thessaloniki before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

If you're up for some more sightseeing, we recommend visiting Arch Of Galerius And Rotunda, a photogenic monument before you head out.

For a last-minute shopping spree in Thessaloniki, Tsimiski Street is nearby. Enjoy a variety of retail stores, dining options, and essential services in one convenient location. Browse through boutiques to find unique and stylish fashion pieces to take home.

Before you conclude your road trip in Greece, drop by another restaurant for a last chance at a memorable dining experience in Thessaloniki.

You’ll then say farewell to Thessaloniki. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Greece!

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Shortly after booking, you’ll receive your full itinerary, including schedules, locations, and everything you need for a stress-free trip.
Personalize your itinerary
Each package includes a professionally crafted itinerary you can tailor to your travel style. A dedicated travel expert will make sure every detail fits your needs perfectly.
Easily make changes
Need to update plans? No problem. Whether before your trip or mid-journey, we’re just seconds away to help with quick adjustments.
Enjoy seamless planning
With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.
Explore with confidence
From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.
Secure your spot
Confirm your package instantly and lock in the best rate with secure payment and guaranteed availability.
Get instant confirmation
Shortly after booking, you’ll receive your full itinerary, including schedules, locations, and everything you need for a stress-free trip.
Personalize your itinerary
Each package includes a professionally crafted itinerary you can tailor to your travel style. A dedicated travel expert will make sure every detail fits your needs perfectly.
Easily make changes
Need to update plans? No problem. Whether before your trip or mid-journey, we’re just seconds away to help with quick adjustments.
Enjoy seamless planning
With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.
Explore with confidence
From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.

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