7-Day Greece Self-Drive Road Trip With Itinerary from Thessaloniki to Kavala Prefecture, Xanthi, Serres, and Larissa and surrounding area

1 / 67
Photo of Saint Paul cathedral in Thessaloniki, Greece.
Perfect travel plans
Everything included
Fully customizable

Description

Included

Flights
Hotel
Select dates
Car rental
Select dates
Tours & tickets
Select dates
Travel plan
From A to Z
Travel agent
24/7 fast service

Description

Experience the freedom of the open road on an unforgettable 7-day road trip in Greece! Embark on a self-drive tour that caters to every traveler, featuring destinations like Thessaloniki, Kavala Prefecture, Alexandroupoli, Xanthi, Krinides, Lydia, Aggitis, Serres, Vergina, Katerini, Larissa, Makrinitsa, Portaria, and Volos.

This perfectly planned road trip itinerary takes you through some of the best places to see in Greece. You will spend 2 nights in Thessaloniki, 1 night in Kavala Prefecture, 1 night in Xanthi, 1 night in Serres, and 1 night in Larissa. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Greece. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have you covered.

Upon arriving in Thessaloniki, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Greece on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Greece. White Tower Of Thessaloniki and Aristotelous Square are just a couple of the bucket-list attractions that await your discovery. Marvel at the remarkable The Umbrellas Sculpture By Zogolopoulos, learn more about the unique Arch Of Galerius And Rotunda, and immerse yourself in the vibrant atmosphere of Agias Sofias Square.

As you hit the open road and drive through Thessaloniki, Kavala Prefecture, Alexandroupoli, Xanthi, Krinides, Lydia, Aggitis, Serres, Vergina, Katerini, Larissa, Makrinitsa, Portaria, and Volos, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Greece. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Greece.

Throughout your road trip in Greece, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Greece.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodations, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in Greece fill up quickly, so book your spot early. Select a date and start planning your road trip in Greece today!

Read more

Travel details

Set your travel details to find the best price

Flights

Round trip
Round trip
Travel dates

Travelers

Rooms

Flights

Compare and choose from the best flights to Thessaloniki

Car

Choose from the best car rental deals or see all options

Driver’s age is 30 - 65
I live in
Pick-up: 10:00
Drop-off: 10:00

Personalize your itinerary

Customize tours under each day and destination

Day 1

Day 1

  • Thessaloniki - Arrival day
  • More
  • Ladadika
  • More

Your road trip adventure in Greece begins as soon as you reach Thessaloniki and pick up your car. You’ll stay here for 1 night and explore what to see in Thessaloniki, sample the local cuisine, and choose from a curated selection of the best hotels and places to stay in the city.

Thessaloniki is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out Ladadika, a must-see neighborhood, and taking a stroll in the city center. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

When you're ready for some downtime, make your way to your chosen hotel. Check-in typically starts between 2 and 4 PM in Thessaloniki. Make yourself at home and unwind before heading out again.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Thessaloniki, it's often a good idea to reserve a table in advance.

Treat yourself to a delicious dinner at Kitchen Bar, an excellent option for tonight's dining. Looking for something different? The Greek offers a tantalizing alternative with its diverse menu. And don’t miss Phanós. Known for great service, it’s a fantastic choice for tonight in Thessaloniki.

Unwind after your meal by stepping into Beetle Bar. This venue is celebrated for its extensive drink selections and cozy vibes. Alternatively, Vogatsikou 3 offers a dynamic and energetic atmosphere for a glass or two. Don’t overlook Souel, another top-rated bar in the area.

Raise a toast to the start of your 7-day road trip in Greece!

Read more
Day 2

Day 2

  • Thessaloniki
  • Kavala
  • More

Drive 161 km, 2 hours 30 min

  • Aristotelous Square
  • Agias Sofias Square
  • White Tower of Thessaloniki
  • The Umbrellas by Zongolopoulos
  • More

Experience an unparalleled adventure on day 2 of your road trip in Greece. This exciting part of your journey invites you to discover the renowned landmarks in 1 place, which are Thessaloniki. At the end of the day, you will retreat to the hotel of your choice in Kavala Prefecture, where will spend 1 night.

Experience Aristotelous Square, a locally renowned public square in the city. Then, head to Agias Sofias Square and soak in the ambiance of this heritage-rich public square.

There are many interesting places to see in Thessaloniki, and when you are ready for more, go to White Tower Of Thessaloniki. This is one of the city’s most spectacular stunning spots of interest. After exploring the monument, visit the interesting The Umbrellas Sculpture By Zogolopoulos.

When you’re done exploring for the day, you’ll drive to your hotel in Kavala Prefecture. Check in and relax before you head out to tour the city.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Kavala Prefecture. Enjoy a relaxing evening as you savor delicious local cuisine.

Enjoy a lovely meal at Meltemi, a top-rated place to have dinner tonight. Alternatively, if your taste buds call for something different, Tsalapeteinos (Tsalapeteinos Urban Farm) is another top choice with a popular menu. You could also check for a table at Marine Cafe Bar Restaurant. As an establishment that consistently gains high praises from customers, it’s an ideal choice in Kavala Prefecture tonight.

Cap off your culinary experience with a visit to some of the most celebrated bars in the area. For instance, Sofita stands out as an excellent choice for a post-dinner cocktail. Alternatively, Beyond Cafe-bar offers an ideal atmosphere to enjoy the pleasures of the night. Brickwall Pub is also a great option that provides a perfect setting for a relaxing evening.

Relax and recharge in preparation for another adventurous day in Greece!

Read more
Day 3

Day 3

  • Kavala
  • Xanthi
  • More

Drive 254 km, 3 hours 23 min

  • Kavala Fort
  • Faliro Park
  • Lighthouse of Alexandroupoli
  • The House of Shadow
  • Dimokratias Square
  • More

On day 3 of your exciting self-drive vacation in Greece, you’ll soak in the magnificence of 3 destinations, including Kavala Prefecture, Alexandroupoli, and Xanthi. When you’re not sightseeing, take time to relax at your chosen hotel in Xanthi, where you’ll be staying for 1 night.

Kavala Fortress leaves a lasting impression. This castle is one of the most often recommended places to visit in Kavala Prefecture.

In between the sights, don’t hesitate to take small detours to explore local stores and eateries. When you’re ready to continue your adventure, head to Lighthouse Of Alexandroupoli. This visually striking lighthouse is a highly recommended experience. Nearby, you'll also find The House Of Shadow and Republic Square. Visit these for an interesting touch to your journey.

After soaking up all the sights on today's itinerary, you'll be ready to head to your accommodation in Xanthi. Xanthi offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

Indulge in a memorable dining experience at one of Xanthi's most popular restaurants, and connect with friendly locals for a true cultural experience.

Savor the flavors at Fanarakia, a top pick for dinner tonight. Alternatively, KooKooVaya Urban Gastronomy beckons with its unique menu offerings. Also, consider Amalthia. With its consistent customer satisfaction, it’s an excellent option for dining in Xanthi tonight.

Explore the vibrant nightlife at Βaiser Cafe-bar after your meal, a hub for lively evenings and memorable moments. Or, head to Mikro Cafe for a great selection of flavorful drinks and a charming setting. Furthermore, Nostos is perfect for those looking to extend their night with a touch of local flavor.

Take some time to reflect on your day and savor another beautiful night in Greece.

Read more
Day 4

Day 4

  • Xanthi
  • Serres Regional Unit
  • More

Drive 194 km, 3 hours 15 min

  • Ancient theatre of Philippi
  • Archaeological Museum of Philippi
  • Holy Baptistery of Saint Lydia of Philippi
  • Cave Aggitis River
  • More

Dive into day 4 of your remarkable road trip in Greece. Today you'll explore 3 destinations, including Krinides, Lydia, and Aggitis. At the end of the day, you’ll unwind at one of the finest accommodations in Serres, where you'll spend 1 night.

No visit to Xanthi is complete without Ancient Theatre Of Philippi. This underrated archeological site is one of the top attractions in the town. Proceed to Archaeological Museum Of Philippi, another must-visit attraction.

As you wander through the inviting streets of Xanthi, soak in the lively ambiance and take the opportunity to snap some photos. Next, head to Holy Baptistery Of Saint Lydia Of Philippi. This worthwhile church is a traveler-favorite. Not far away, you’ll find Aggitis River Cave, another key site on your sightseeing itinerary.

At the end of the day, you will drive to Serres, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

Serres is a place where the culinary landscape is as diverse as its attractions. So before the day ends, treat your palate to a taste of local cuisine at one of the best restaurants in Serres.

Have a fantastic dining experience at Oyzadikon To Bakalikon, a highly recommended choice for tonight's dinner. If you're looking to mix things up, KENTRIKON Ouzomezedopoleio offers an enticing alternative with its varied menu. Additionally, Sousouráda is worth considering. Renowned for satisfying diners, it’s an ideal option for tonight in Serres.

To truly maximize your evening out, consider visiting Avissunia Kafe after dinner. This bar is known for offering some of the best drinks and vibes in the city. Alternatively, head to Resalto Pub, another bar with an inviting ambiance. Similarly, 1800 Cafe Bar also offers a great atmosphere, ensuring a night filled with enjoyment and relaxation.

As the day draws to a close, take a moment to unwind and prepare for the next exciting chapter of your road trip in Greece.

Read more
Day 5

Day 5

  • Serres Regional Unit
  • Larissa
  • More

Drive 277 km, 3 hours 49 min

  • Liberty Square
  • Polycentric Museum of Aigai (Aegae) - Main Building
  • Museum of the Royal Tombs at Aigai (Aegae)
  • Katerini Municipal Park
  • More

On day 5 of your road trip in Greece, your travel plans include 3 stops at the most scenic, wondrous, and interesting places in the region. Serres, Vergina, and Katerini are on today's agenda. In the evening, you’ll end up in Larissa, where you will stay for 1 night.

Check out the worthwhile public square, Liberty Square. Afterward, continue to Polycentric Museum Of Aigai (aegae) - Main Building, a museum every traveler should visit. As you explore Serres’s charming streets, take in the lively atmosphere and get to know the character of the city.

Next, make your way to Museum Of The Royal Tombs At Aigai (aegae). This underrated museum is an essential stop. Following that, head to Katerini Municipal Park, another must-visit site that will enhance your experience.

When you’re done exploring for the day, you’ll drive to your hotel in Larissa. Check in and relax before you head out to tour the city.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Larissa, it's often a good idea to reserve a table in advance.

Enjoy a delicious meal at Nonna Rossa, a top-rated dining destination in Larissa. If you're in the mood to try something new, consider Vosporos | Restaurant • Bar, another top spot with a mouthwatering menu. You might also want to secure a reservation at THE ALLEY. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Larissa this evening.

After savoring a delicious meal, step into the vibrant nightlife at Sherlock Easy Bar, where the evening is just getting started. In the same way, Kiou offers a unique charm perfect for experiencing the local bar scene in Larissa. Wisedog is another top-recommended bar that is sure to get you into the mood for some dancing and celebrating.

Raise your glass to another unforgettable day in Greece!

Read more
Day 6

Day 6

  • Larissa
  • Thessaloniki
  • More

Drive 294 km, 4 hours 15 min

  • Makrinitsa Central Square
  • Centaurs' path
  • Saint Konstantinos Park
  • Παραλία Βόλου
  • More

Your itinerary for day 6 of your road trip in Greece includes 3 stops and features some of the highlights of Makrinitsa, Portaria, and Volos. At the end of the day, enjoy the comforts of a top-rated hotel in Thessaloniki, where you'll spend 1 night.

Makrinitsa is an ideal stop early in the day. This intriguing public square is a must-visit in the village. When you’re ready for your next discovery, continue to Centaurs' Path, which may be one of the most majestic places you will experience today.

One of the best things about exploring Larissa on a self-guided tour is that you set the pace. There’s plenty of time for detours and discovering hidden gems. When you’re ready for your next stop, make your way to Saint Konstantinos Park, a beloved park in the village. If you’re up for more discoveries, don’t forget to reserve some time for Paralia Voloy.

After soaking up all the sights on today's itinerary, you'll be ready to head to your accommodation in Thessaloniki. Thessaloniki offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

After a day of adventure, treat yourself to an exquisite dinner at one of Thessaloniki's best restaurants.

Treat yourself to a delightful dinner at Mamalouka, highly recommended for tonight's dining. Or, if you're feeling adventurous, why not try Clochard? It's another excellent option with a diverse menu. Consider reserving a table at Sofi's House Restaurant as well. Known for its consistent customer satisfaction, it’s an ideal pick for tonight in Thessaloniki.

If you’re not ready to end the night just yet, Castra- All Day Terrace Bar offers a perfect venue to relax and savor a drink. Similarly, Barbaben - Bar/ba/ben is well-suited for those looking to unwind in a social setting. Apallou is another excellent spot to enjoy a nightcap after a delightful meal.

As the sun sets, rest up and recharge for the next leg of your road trip in Greece.

Read more
Day 7

Day 7

  • Thessaloniki - Departure day
  • More
  • Arch of Galerius
  • More

Day 7 of your road trip in Greece is your departure day. This is your chance to catch a last glimpse of Thessaloniki before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

If you're up for some more sightseeing, begin at Arch Of Galerius And Rotunda. This interesting monument is a hotspot among locals.

Take advantage of your accommodation's proximity to Thessaloniki’s shopping district for some last-minute bargain hunting. Explore local shops for souvenirs to remember your trip or find unique gifts for loved ones. Discover boutiques offering an array of stylish fashion choices.

Before you conclude your road trip in Greece, drop by another restaurant for a last chance at a memorable dining experience in Thessaloniki.

Treat yourself to a delicious dinner at Enoches Bar, an excellent option for tonight's dining. Looking for something different? O Loytros offers a tantalizing alternative with its diverse menu. And don’t miss rOOTS.

You’ll then say farewell to Thessaloniki. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Greece!

Read more

How it works

Book your journey with Europe’s biggest travel platform—expert itineraries, instant confirmation, and full flexibility with 24/7 support.

Secure your spot
Confirm your package instantly and lock in the best rate with secure payment and guaranteed availability.
Get instant confirmation
Shortly after booking, you’ll receive your full itinerary, including schedules, locations, and everything you need for a stress-free trip.
Personalize your itinerary
Each package includes a professionally crafted itinerary you can tailor to your travel style. A dedicated travel expert will make sure every detail fits your needs perfectly.
Easily make changes
Need to update plans? No problem. Whether before your trip or mid-journey, we’re just seconds away to help with quick adjustments.
Enjoy seamless planning
With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.
Explore with confidence
From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.
Secure your spot
Confirm your package instantly and lock in the best rate with secure payment and guaranteed availability.
Get instant confirmation
Shortly after booking, you’ll receive your full itinerary, including schedules, locations, and everything you need for a stress-free trip.
Personalize your itinerary
Each package includes a professionally crafted itinerary you can tailor to your travel style. A dedicated travel expert will make sure every detail fits your needs perfectly.
Easily make changes
Need to update plans? No problem. Whether before your trip or mid-journey, we’re just seconds away to help with quick adjustments.
Enjoy seamless planning
With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.
Explore with confidence
From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.

We guarantee

Your trip is protected, personalized, and priced right. No surprises, no stress.

Similar travel packages

Discover other popular vacations in Greece

Link to appstore phone
Install Europe’s biggest travel app

Download Europe’s biggest travel marketplace to your phone to manage your entire trip in one place

Scan this QR code with your phone camera and press the link that appears to add Europe’s biggest travel marketplace into your pocket. Enter your phone number or email address to receive an SMS or email with the download link.