7-Day Greece Self-Drive Road Trip With Itinerary from Thessaloniki to Kavala Prefecture, Xanthi, Serres, and Larissa and surrounding area

1 / 101
Photo of Saint Paul cathedral in Thessaloniki, Greece.
Perfect travel plans
Everything included
Fully customizable

Description

Included

Flights
Hotel
Select dates
Car rental
Select dates
Tours & tickets
Select dates
Travel plan
From A to Z
Travel agent
24/7 fast service

Description

Escape the ordinary with this exciting 7-day road trip through Greece. Explore diverse landscapes, discover lively cities, and prepare for an unforgettable journey!

This perfectly planned road trip itinerary takes you through some of the best places to see in Greece. You will spend 2 nights in Thessaloniki, 1 night in Kavala Prefecture, 1 night in Xanthi, 1 night in Serres, and 1 night in Larissa. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Greece. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have you covered.

Upon arriving in Thessaloniki, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Greece on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Greece. White Tower Of Thessaloniki and Aristotelous Square are just a couple of the bucket-list attractions that await your discovery.

As you hit the open road and drive through Thessaloniki, Kavala Prefecture, Alexandroupoli, Xanthi, Krinides, Lydia, Aggitis, Serres, Vergina, Katerini, Larissa, Makrinitsa, Portaria, and Volos, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Greece. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Greece.

Throughout your road trip in Greece, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Greece.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodations, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in Greece fill up quickly, so book your spot early. Select a date and start planning your road trip in Greece today!

Read more

Travel details

Set your travel details to find the best price

Flights

Round trip
Round trip
Travel dates

Travelers

Rooms

Flights

Compare and choose from the best flights to Thessaloniki

Car

Choose from the best car rental deals or see all options

Driver’s age is 30 - 65
I live in
Pick-up: 10:00
Drop-off: 10:00

Personalize your itinerary

Customize tours under each day and destination

Day1

Day 1

  • Thessaloniki - Arrival day
  • More
  • Ladadika
  • More

Your road trip adventure in Greece begins as soon as you reach Thessaloniki and pick up your car. You’ll stay here for 1 night and explore what to see in Thessaloniki, sample the local cuisine, and choose from a curated selection of the best hotels and places to stay in the city.

Thessaloniki is a beautiful city with plenty to discover. Taking a stroll in the city center is a great alternative. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

As afternoon approaches, head to your chosen hotel in Thessaloniki. Check-in typically starts around 2 to 4 PM at hotels in Greece. We recommend staying at a central location for easy access to key areas in the city.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Thessaloniki, it's often a good idea to reserve a table in advance.

Enjoy a lovely dining experience at Kitchen Bar, a popular restaurant in Thessaloniki. This acclaimed establishment has earned the admiration of countless food lovers in the city. Alternatively, experience a taste of Thessaloniki at The Greek, another great place to eat. With a menu designed to impress, it promises a journey of flavors that will leave you captivated. A third option to check out is the top-rated Phanós. It’s yet another ideal choice to enhance your time in Thessaloniki tonight.

After savoring a delicious meal, step into the vibrant nightlife at Beetle Bar, where the evening is just getting started. In the same way, Vogatsikou 3 offers a unique charm perfect for experiencing the local bar scene in Thessaloniki. Souel is another top-recommended bar that is sure to get you into the mood for some dancing and celebrating.

Raise a toast to the start of your 7-day road trip in Greece!

Read more
Day2

Day 2

  • Thessaloniki
  • Kavala
  • More

Drive 161 km, 2 hours 30 min

  • Aristotelous Square
  • Agias Sofias Square
  • White Tower of Thessaloniki
  • The Umbrellas by Zongolopoulos
  • More

Dive into day 2 of your remarkable road trip in Greece. Today you'll explore 1 destination, including Thessaloniki. At the end of the day, you’ll unwind at one of the finest accommodations in Kavala Prefecture, where you'll spend 1 night.

Your adventure in Thessaloniki is only getting started when you visit Aristotelous Square, a locally renowned local hot spot. Another notable attraction to explore is Agias Sofias Square. This well-known public square is known for its visually striking appeal.

After soaking in the highlights of these sights, take some time to wander Thessaloniki's streets and immerse yourself in the local atmosphere. When you're ready to continue your sightseeing adventure, head to White Tower Of Thessaloniki. This picture-perfect monument offers a fascinating experience that many visitors find memorable. The Umbrellas Sculpture By Zogolopoulos is also worth visiting.

When you’re done exploring for the day, you’ll drive to your hotel in Kavala Prefecture. Check in and relax before you head out to tour the city.

After a day of adventure, treat yourself to an exquisite dinner at one of Kavala Prefecture's best restaurants.

Make sure to reserve a table at Meltemi, an iconic dining spot in Kavala Prefecture. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Tsalapeteinos (Tsalapeteinos Urban Farm), a popular restaurant in Kavala Prefecture. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of Marine Cafe Bar Restaurant, a hidden gem nestled in Kavala Prefecture. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

After your delicious meal, get a taste of the vibrant nightlife with a visit to Sofita, known for its inviting atmosphere. Beyond Cafe-bar is another great option if you’re looking for a place to get the night started. Similarly, Brickwall Pub provides a great setting to enjoy the night away.

As the day draws to a close, take a moment to unwind and prepare for the next exciting chapter of your road trip in Greece.

Read more
Day3

Day 3

  • Kavala
  • Alexandroupoli
  • Xanthi
  • More

Drive 254 km, 3 hours 23 min

  • Kavala Fort
  • Faliro Park
  • Lighthouse of Alexandroupoli
  • The House of Shadow
  • Dimokratias Square
  • More

On day 3 of your exciting self-drive vacation in Greece, you’ll soak in the magnificence of 3 destinations, including Kavala Prefecture, Alexandroupoli, and Xanthi. When you’re not sightseeing, take time to relax at your chosen hotel in Xanthi, where you’ll be staying for 1 night.

Start your day at Kavala Fortress. This romantic castle is a locally appreciated place to see in Kavala Prefecture. Then, wander over to Faliro Park.

It’s time to gear up for the next part of your road trip adventure. Under favorable conditions, your drive to Alexandroupoli may take around 1 hour 41 min. Upon your arrival in Alexandroupoli, you’ll be greeted with the opportunity to do some sightseeing and exploring.

Our first attraction recommendation in Alexandroupoli is Lighthouse Of Alexandroupoli, an up-and-coming lighthouse that draws attention for its enchanting features.

Xanthi’s wonders await as you prepare for another journey on the road, leaving the breathtaking surroundings of Alexandroupoli behind. This drive usually takes around 1 hour 15 min. Xanthi welcomes you with a multitude of unique vacation experiences.

Spend your afternoon discovering The House Of Shadow, an often recommended art installation known for its detailed features. Next, continue your sightseeing at Republic Square, an up-and-coming public square.

After soaking up all the sights on today's itinerary, you'll be ready to head to your accommodation in Xanthi. Xanthi offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Xanthi, it's often a good idea to reserve a table in advance.

Have a fantastic dining experience at Fanarakia, a highly recommended choice for tonight's dinner. If you're looking to mix things up, KooKooVaya Urban Gastronomy offers an enticing alternative with its varied menu. Additionally, Amalthia is worth considering. Renowned for satisfying diners, it’s an ideal option for tonight in Xanthi.

After savoring a delicious meal, step into the vibrant nightlife at Βaiser Cafe-bar, where the evening is just getting started. In the same way, Mikro Cafe offers a unique charm perfect for experiencing the local bar scene in Xanthi. Nostos is another top-recommended bar that is sure to get you into the mood for some dancing and celebrating.

Raise your glass to another unforgettable day in Greece!

Read more
Day4

Day 4

  • Xanthi
  • Krinides
  • Lydia
  • Aggitis
  • Serres Regional Unit
  • More

Drive 194 km, 3 hours 15 min

  • Ancient theatre of Philippi
  • Archaeological Museum of Philippi
  • Holy Baptistery of Saint Lydia of Philippi
  • Cave Aggitis River
  • More

Experience an unparalleled adventure on day 4 of your road trip in Greece. This exciting part of your journey invites you to discover the renowned landmarks in 3 places, which are Krinides, Lydia, and Aggitis. At the end of the day, you will retreat to the hotel of your choice in Serres, where will spend 1 night.

It’s time to gear up for the next part of your road trip adventure. Under favorable conditions, your drive to Krinides may take around 55 min. Upon your arrival in Krinides, you’ll be greeted with the opportunity to do some sightseeing and exploring.

One of our top recommendations for your sightseeing is Ancient Theatre Of Philippi. Spend some time admiring the breathtaking features of the archeological site before you continue to your next stop. Then, head to Archaeological Museum Of Philippi. This beloved museum is a traveler-favorite in the town.

When you’re ready to jump back into the car and say goodbye to Lydia, you’ll hit the road in the direction of Aggitis. This drive usually takes around 42 min.

Set out on a self-guided sightseeing tour at Holy Baptistery Of Saint Lydia Of Philippi and explore the historic features.

It’s time to gear up for the next part of your road trip adventure. Under favorable conditions, your drive to Aggitis may take around 42 min. Upon your arrival in Aggitis, you’ll be greeted with the opportunity to do some sightseeing and exploring.

For a more meaningful self-guided tour of the town's best attractions, visit Aggitis River Cave, a frequently visited cave that is sure to impress. Take in the surroundings and enjoy the freedom of exploring at your own pace before you continue your journey.

At the end of the day, you will drive to Serres, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Serres. Enjoy a relaxing evening as you savor delicious local cuisine.

Make sure to reserve a table at Oyzadikon To Bakalikon, an iconic dining spot in Serres. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of KENTRIKON Ouzomezedopoleio, a popular restaurant in Serres. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of Sousouráda, a hidden gem nestled in Serres. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

Keep the evening going at Avissunia Kafe, a great choice for enjoying the after-dinner hours with a drink. You could also go to Resalto Pub, which offers a similarly pleasant setting and great drinks. Another option is 1800 Cafe Bar, which provides an inviting environment for unwinding after a busy day out.

Relax and look forward to more memorable moments to come!

Read more
Day5

Day 5

  • Serres Regional Unit
  • Vergina
  • Katerini
  • Larissa
  • More

Drive 277 km, 3 hours 49 min

  • Liberty Square
  • Polycentric Museum of Aigai (Aegae) - Main Building
  • Museum of the Royal Tombs at Aigai (Aegae)
  • Katerini Municipal Park
  • More

On day 5 of your road trip in Greece, your travel plans include 3 stops at the most scenic, wondrous, and interesting places in the region. Serres, Vergina, and Katerini are on today's agenda. In the evening, you’ll end up in Larissa, where you will stay for 1 night.

Let Liberty Square set the tone for the day. Spend some time admiring this eye-catching public square before continuing your journey.

When you’ve had your share of Serres, prepare for your next destination. Admire the views and listen to some good music as you drive in the direction of Vergina. Your travel time is around 1 hour 46 min.

Spend your afternoon discovering Polycentric Museum Of Aigai (aegae) - Main Building, an increasingly popular museum known for its UNESCO world heritage-listed features. Next, continue your sightseeing at Museum Of The Royal Tombs At Aigai (aegae), a beloved museum.

Once you're ready to continue your road trip, it's time to buckle up and drive, eagerly anticipating your arrival in Katerini. This drive usually takes around 53 min, without any stops or traffic disruptions.

Savor the day by heading to Katerini Municipal Park, a worthwhile park that draws visitors from near and far.

When you’re done exploring for the day, you’ll drive to your hotel in Larissa. Check in and relax before you head out to tour the city.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Larissa. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Treat yourself to a delightful dinner at Nonna Rossa, highly recommended for tonight's dining. Or, if you're feeling adventurous, why not try Vosporos | Restaurant • Bar? It's another excellent option with a diverse menu. Consider reserving a table at THE ALLEY as well. Known for its consistent customer satisfaction, it’s an ideal pick for tonight in Larissa.

Explore the vibrant nightlife at Sherlock Easy Bar after your meal, a hub for lively evenings and memorable moments. Or, head to Kiou for a great selection of flavorful drinks and a charming setting. Furthermore, Wisedog is perfect for those looking to extend their night with a touch of local flavor.

Say good night to Larissa and look forward to another great day of your road trip in Greece!

Read more
Day6

Day 6

  • Larissa
  • Makrinitsa
  • Portaria
  • Volos
  • Thessaloniki
  • More

Drive 294 km, 4 hours 15 min

  • Makrinitsa Central Square
  • Centaurs' path
  • Saint Konstantinos Park
  • Παραλία Βόλου
  • More

Your itinerary for day 6 of your road trip in Greece includes 3 stops and features some of the highlights of Makrinitsa, Portaria, and Volos. At the end of the day, enjoy the comforts of a top-rated hotel in Thessaloniki, where you'll spend 1 night.

When you’ve had your share of Larissa, prepare for your next destination. Admire the views and listen to some good music as you drive in the direction of Makrinitsa. Your travel time is around 1 hour 9 min.

Savor the day by heading to Makrinitsa, an often recommended public square that draws visitors from near and far.

Once you're ready to continue your road trip, it's time to buckle up and drive, eagerly anticipating your arrival in Portaria. This drive usually takes around 11 min, without any stops or traffic disruptions.

Enjoy sightseeing at your own pace and allow yourself time to explore the beautiful surroundings. Take your self-guided tour to Centaurs' Path, an often recommended hiking area that everyone visiting Portaria should see.

When you’ve had your share of Portaria, prepare for your next destination. Admire the views and listen to some good music as you drive in the direction of Volos. Your travel time is around 27 min.

Enjoy sightseeing at your own pace and allow yourself time to explore the beautiful surroundings. Take your self-guided tour to Saint Konstantinos Park, a worthwhile park that everyone visiting Volos should see. Next, head to Paralia Voloy. This eye-catching beach is one of the most increasingly popular attractions in the region.

After soaking up all the sights on today's itinerary, you'll be ready to head to your accommodation in Thessaloniki. Thessaloniki offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

Indulge in a memorable dining experience at one of Thessaloniki's most popular restaurants, and connect with friendly locals for a true cultural experience.

Savor the flavors at Mamalouka, a top pick for dinner tonight. Alternatively, Clochard beckons with its unique menu offerings. Also, consider Sofi's House Restaurant. With its consistent customer satisfaction, it’s an excellent option for dining in Thessaloniki tonight.

If you’re not ready to end the night just yet, Castra- All Day Terrace Bar offers a perfect venue to relax and savor a drink. Similarly, Barbaben - Bar/ba/ben is well-suited for those looking to unwind in a social setting. Apallou is another excellent spot to enjoy a nightcap after a delightful meal.

Celebrate another amazing day of your road trip adventure in Greece!

Read more
Day7

Day 7

  • Thessaloniki - Departure day
  • More
  • Arch of Galerius
  • More

Day 7 of your road trip in Greece is your departure day. This is your chance to catch a last glimpse of Thessaloniki before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

If you're up for some more sightseeing, begin at Arch Of Galerius And Rotunda. This captivating monument is a hotspot among locals.

For a last-minute shopping spree in Thessaloniki, Modiano Market is nearby. Enjoy a variety of retail stores, dining options, and essential services in one convenient location.

Before you conclude your road trip in Greece, drop by another restaurant for a last chance at a memorable dining experience in Thessaloniki.

If you're in the mood to try something new, consider O Loytros, another top spot with a mouthwatering menu.

You’ll then say farewell to Thessaloniki. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Greece!

Read more

How it works

Book your journey with Europe’s biggest travel platform—expert itineraries, instant confirmation, and full flexibility with 24/7 support.

Secure your spot
Confirm your package instantly and lock in the best rate with secure payment and guaranteed availability.
Get instant confirmation
Shortly after booking, you’ll receive your full itinerary, including schedules, locations, and everything you need for a stress-free trip.
Personalize your itinerary
Each package includes a professionally crafted itinerary you can tailor to your travel style. A dedicated travel expert will make sure every detail fits your needs perfectly.
Easily make changes
Need to update plans? No problem. Whether before your trip or mid-journey, we’re just seconds away to help with quick adjustments.
Enjoy seamless planning
With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.
Explore with confidence
From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.
Secure your spot
Confirm your package instantly and lock in the best rate with secure payment and guaranteed availability.
Get instant confirmation
Shortly after booking, you’ll receive your full itinerary, including schedules, locations, and everything you need for a stress-free trip.
Personalize your itinerary
Each package includes a professionally crafted itinerary you can tailor to your travel style. A dedicated travel expert will make sure every detail fits your needs perfectly.
Easily make changes
Need to update plans? No problem. Whether before your trip or mid-journey, we’re just seconds away to help with quick adjustments.
Enjoy seamless planning
With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.
Explore with confidence
From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.

We guarantee

Your trip is protected, personalized, and priced right. No surprises, no stress.

Similar travel packages

Discover other popular vacations in Greece

Link to appstore phone
Install Europe’s biggest travel app

Download Europe’s biggest travel marketplace to your phone to manage your entire trip in one place

Scan this QR code with your phone camera and press the link that appears to add Europe’s biggest travel marketplace into your pocket. Enter your phone number or email address to receive an SMS or email with the download link.