Introduction
Unpack your bags at one of the 10 best hotels and places to stay in Mytilene. These handpicked accommodations are chosen for their welcoming atmosphere and convenient locations that keep you close to the action. See how they make every moment of your stay in Mytilene unforgettable.
Finding your ideal place to stay in Mytilene doesn't have to be a challenge. We've reviewed the biggest selection of hotels in Mytilene to bring you the 10 best places to stay, each offering something special for your trip.
Feeling overwhelmed?
Once you've chosen your must-visit attractions, the only thing left is picking your perfect stay. Scroll down for everything you need to know about where to stay in Mytilene and start planning your adventure today!
Top 5 Best Neighborhoods To Stay in Mytilene
Choosing the best neighborhoods to stay in Mytilene is key to making the most of your visit. The right location can give you easy access to top sights, great local food, and the unique charm of this Greek island city. Here are the top five neighborhoods to consider, ranked from good to best, to help you decide where to book your stay.
5. Epano Skala - Historic and Local
Epano Skala is the best neighborhood to stay in Mytilene if you want a local vibe and affordable guesthouses. This area features the historic Yeni Mosque and the old market, offering a glimpse into the city's multicultural past. It’s a quieter part of town but still within walking distance to the waterfront.4. Tsamakia Beach - Relaxed and Scenic
Tsamakia Beach is the best neighborhood to stay in Mytilene for travelers who want easy beach access and sea views. The area has several mid-range hotels and is ideal for families or couples seeking a quiet, scenic spot. The sandy beach is perfect for swimming, and you’re still close to the city center.3. Sourada - Elegant and Residential
Sourada is the best neighborhood to stay in Mytilene if you prefer a peaceful, upscale environment. Known for its neoclassical mansions, this area offers boutique hotels and stylish guesthouses. It’s a great choice for those interested in architecture and a more refined atmosphere, with easy transport links to the old town.2. Varia - Artistic and Authentic
Varia is the best neighborhood to stay in Mytilene for art lovers and culture seekers. Home to the famous Theophilos Museum and close to the Teriade Museum, Varia has a relaxed feel and affordable accommodations. It’s ideal if you want to explore local culture while staying in a quieter residential area.1. Mytilene Old Town - Central and Lively
Mytilene Old Town is the best neighborhood to stay in Mytilene for first-time visitors who want to be in the heart of the action. Here, you'll find the impressive Mytilene Castle, plenty of cafes, shops, and a range of hotels from budget to boutique. Its central location makes it easy to explore all major attractions on foot.Explore Mytilene Stays
Choose your Mytilene stay style here. Browse by category to find your next stay in Mytilene.
Search for Places To Stay in Mytilene
Browse the largest selection of hotels and accommodations in Mytilene, all backed by a best-price guarantee. Whether you’re looking for a central location, pet-friendly options, or a place with a pool, simply enter your travel dates to find your perfect stay in Mytilene.
The 10 Best Places To Stay in Mytilene
Discover our updated list of the top 10 best places to stay in Mytilene, chosen for their exceptional comfort, top-rated service, and prime locations. From luxurious retreats to budget-friendly spots, there’s a hotel for every traveler.
Find your perfect base below and make your Mytilene adventure truly unforgettable!
10. Mirsini
- Comfort Level: 2-star hotel
- Guest Rating: 4.6 out of 5 stars from 236 reviews
- Location: Just 12.6 miles (20.3 km) from the city center
- Nearest Attractions: Παναγία της Αγιάσου and Castle of Mytilene
- Check-in: 12:00 PM
- Check-out: 12:00 PM
- Starting Rate: 78 EUR
Located 12.6 miles (20.3 km) from the city center, Mirsini puts you close to popular sights like Παναγία της Αγιάσου and Castle of Mytilene. Rooms are available starting at 78 EUR.
What makes Mirsini even better is its warm hospitality and exemplary service. Adding to the experience are the convenient amenities, like room service, 24-hour front desk, garden, terrace, family rooms, free Wi-Fi, and air conditioning, designed to enhance every stay.
With clean and well-designed accommodations, a fantastic location, and excellent value, Mirsini stands out as an appealing choice for anyone considering where to stay in Mytilene.
9. Zaira Hotel
- Comfort Level: 4-star hotel
- Guest Rating: 4.6 out of 5 stars from 315 reviews
- Location: Just 4.2 miles (6.7 km) from the city center
- Distance from Mytilene International Airport: 3.9 miles (6.2 km)
- Nearest Attractions: Castle of Mytilene and Παναγία της Αγιάσου
- Check-in: 3:00 PM
- Check-out: 11:00 AM
- Starting Rate: 139 EUR
Guests at Zaira Hotel benefit from a range of amenities, including garden, restaurant, room service, bar, family rooms, hot tub, free Wi-Fi, air conditioning, and swimming pool. It offers value for money, with room rates starting from 139 EUR.
Zaira Hotel has a convenient location, just 4.2 miles (6.7 km) from the city center. It provides easy access to landmarks such as Castle of Mytilene and Παναγία της Αγιάσου.
Located near prominent attractions, Zaira Hotel offers a refined stay experience in Mytilene. Its commitment to comfort and quality service ensures that guests have a pleasant and relaxing visit.
8. Sappho Studios
- Guest Rating: 4.6 out of 5 stars from 326 reviews
- Location: Just 2 miles (3.2 km) from the city center
- Distance from Mytilene International Airport: 2.3 miles (3.7 km)
- Nearest Attractions: Castle of Mytilene and Παναγία της Αγιάσου
- Check-in: 1:00 PM
- Check-out: 11:00 AM
- Starting Rate: 92 EUR
This renowned vacation rental apartment boasts convenient amenities, including air conditioning, garden, family rooms, terrace, and free Wi-Fi.
The vacation rental apartment's location, just 2 miles (3.2 km) from Mytilene's dynamic center, allows easy access to standout attractions such as the top-rated Castle of Mytilene and the captivating Παναγία της Αγιάσου.
Beyond its stylish accommodations, Sappho Studios captivates with its prompt service. Overall, staying one night or two at Sappho Studios during a trip to Mytilene offers a memorable experience.
With Sappho Studios, guests step into a world of extraordinary service and indulgent comfort. Room rates start from 92 EUR, making Sappho Studios a standout choice for those deciding where to stay in Mytilene.
7. Oikies Small Elegant Houses
- Comfort Level: 3-star hotel
- Guest Rating: 4.4 out of 5 stars from 435 reviews
- Location: Just 3 miles (4.8 km) from the city center
- Distance from Mytilene International Airport: 1.6 miles (2.5 km)
- Nearest Attractions: Castle of Mytilene and Παναγία της Αγιάσου
- Check-in: 2:00 PM
- Check-out: 12:00 PM
- Starting Rate: 117 EUR
Conveniently located just 3 miles (4.8 km) from the city center, this hotel provides easy access to attractions like Castle of Mytilene and Παναγία της Αγιάσου.
Guests appreciate Oikies Small Elegant Houses for its excellent and functional amenities, including air conditioning, 24-hour front desk, room service, bar, restaurant, free Wi-Fi, airport shuttle, swimming pool, garden, and family rooms. The hotel also boasts a warm ambiance and guest-centered service.
At Oikies Small Elegant Houses, rooms are well-designed and priced from 117 EUR. Guests can look forward to a comfortable stay that enhances their overall experience in Mytilene.
6. Elysion Hotel
- Comfort Level: 5-star hotel
- Guest Rating: 4.4 out of 5 stars from 446 reviews
- Location: Just 3.4 miles (5.5 km) from the city center
- Distance from Mytilene International Airport: 0.9 miles (1.5 km)
- Nearest Attractions: Castle of Mytilene and Παναγία της Αγιάσου
- Check-in: 3:00 PM
- Check-out: 11:00 AM
- Starting Rate: 181 EUR
Conveniently located just 3.4 miles (5.5 km) from the city center, Elysion Hotel makes it easy to visit popular attractions like Castle of Mytilene and Παναγία της Αγιάσου.
The hotel is highly regarded for its functional amenities, including air conditioning, garden, terrace, room service, family rooms, bar, restaurant, airport shuttle, swimming pool, and 24-hour front desk.
During your stay, enjoy hiking, water sports facilities, and tennis court, further enhancing your time in Mytilene. Entertainment options such as board games and live music or performances ensure something for everyone.
Room rates at Elysion Hotel start from 181 EUR. Overall, this property offers value for money, making it suitable for travelers seeking a great experience.
5. Heliotrope The Studios
- Guest Rating: 4.4 out of 5 stars from 573 reviews
- Location: Just 0.3 miles (0.4 km) from the city center
- Distance from Mytilene International Airport: 5 miles (8 km)
- Nearest Attractions: Castle of Mytilene and Παναγία της Αγιάσου
- Check-in: 3:00 PM
- Check-out: 11:00 AM
- Starting Rate: 68 EUR
At the vacation rental apartment, guests can enjoy amenities such as air conditioning, garden, terrace, room service, family rooms, and free Wi-Fi.
Heliotrope The Studios benefits from a perfect location and is situated 0.3 miles (0.4 km) from the city center. Nearby attractions like Castle of Mytilene and Παναγία της Αγιάσου are easily accessible.
Offering excellent value for money, room rates start at 68 EUR for the cheapest options. Guests can expect both comfort and quality, no matter which option they choose.
4. Elies Residences
- Guest Rating: 4.8 out of 5 stars from 213 reviews
- Location: Just 3.1 miles (5 km) from the city center
- Distance from Mytilene International Airport: 1.3 miles (2.2 km)
- Nearest Attractions: Castle of Mytilene and Παναγία της Αγιάσου
- Check-in: 3:00 PM
- Check-out: 12:00 PM
- Starting Rate: 136 EUR
The vacation rental apartment is situated 3.1 miles (5 km) from the city center. Its perfect location places it near notable attractions like Castle of Mytilene and Παναγία της Αγιάσου, ensuring easy access to these points of interest.
Elies Residences features essential amenities, including garden, terrace, family rooms, free Wi-Fi, air conditioning, and swimming pool. Room rates at this vacation rental apartment start at 136 EUR.
With its blend of comfort, style, and prime location, Elies Residences stands out as a top choice among travelers to Mytilene. Its thoughtful amenities and proximity to top attractions in the city make it a standout option for your visit.
3. Theofilos Paradise Boutique Hotel
- Comfort Level: 4-star hotel
- Guest Rating: 4.6 out of 5 stars from 538 reviews
- Location: Just 0.3 miles (0.5 km) from the city center
- Distance from Mytilene International Airport: 4.3 miles (6.8 km)
- Nearest Attractions: Castle of Mytilene and Παναγία της Αγιάσου
- Check-in: 2:00 PM
- Check-out: 11:00 AM
- Starting Rate: 101 EUR
This 4-star hotel has a perfect location and places you just 0.3 miles (0.5 km) from the city center. Nearby attractions include Castle of Mytilene and Παναγία της Αγιάσου.
Amenities at Theofilos Paradise Boutique Hotel include air conditioning, 24-hour front desk, garden, terrace, room service, bar, restaurant, airport shuttle, swimming pool, sauna, free Wi-Fi, family rooms, and spa. Room rates start at 101 EUR.
Recognized among the top 10 best places to stay in Mytilene, Theofilos Paradise Boutique Hotel ensures a memorable and comfortable experience for all guests.
2. Loriet Hotel
- Guest Rating: 4.3 out of 5 stars from 1617 reviews
- Location: Just 1.9 miles (3.1 km) from the city center
- Distance from Mytilene International Airport: 2.4 miles (3.9 km)
- Nearest Attractions: Castle of Mytilene and Παναγία της Αγιάσου
- Check-in: 3:00 PM
- Check-out: 11:00 AM
- Starting Rate: 132 EUR
Moreover, the location is perfect. Loriet Hotel is just 1.9 miles (3.1 km) from the city center. You’ll find it conveniently close to attractions like Castle of Mytilene and Παναγία της Αγιάσου.
In addition, the vacation rental apartment offers convenient and functional amenities, including air conditioning, garden, terrace, room service, family rooms, bar, restaurant, airport shuttle, swimming pool, and free Wi-Fi.
Guests can enjoy entertainment options such as board games during their stay. There are also fun activities to enjoy, including fishing, water sports facilities, and diving.
Room rates at Loriet Hotel start at 132 EUR. Overall, Loriet Hotel provides a comfortable and convenient stay, making it one of the best vacation rental apartment options in Mytilene.
1. Porto Lesvos
- Comfort Level: 2-star hotel
- Guest Rating: 4.4 out of 5 stars from 1155 reviews
- Location: Just 0.3 miles (0.5 km) from the city center
- Distance from Mytilene International Airport: 4.4 miles (7 km)
- Nearest Attractions: Castle of Mytilene and Παναγία της Αγιάσου
- Check-in: 7:30 AM
- Check-out: 11:00 AM
- Starting Rate: 44 EUR
Conveniently situated just 0.3 miles (0.5 km) from the vibrant city center, Porto Lesvos's perfect location provides easy access to Mytilene's top attractions, including the renowned Chios Mastic Museum and Castle of Chios.
Guests appreciate its outstanding amenities, including air conditioning, 24-hour front desk, room service, restaurant, and free Wi-Fi.
A stay at Porto Lesvos promises an incredible experience, making it an unforgettable choice for your visit to Mytilene, Greece. With room rates starting at 44 EUR, Porto Lesvos offers excellent value.
What To Discover Next in Mytilene
Picking where to stay in Mytilene is just the start of your adventure. Mytilene is a city full of history, stunning architecture, and lively cultural traditions, giving every visitor the chance for an unforgettable adventure
Whether it's the cultural landmarks or the local flavors that excite you the most, there are endless ways to experience what Mytilene is all about.
With so much to see and do, having the right travel arrangements is key. So don't wait, explore the links below for a seamless trip to Mytilene!
