10-Day Italy Self-Drive Road Trip With Itinerary from Genoa to La Spezia, Florence, San Gimignano, and Rome

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Photo of Sand beach in Camogli by Genoa, Italy.
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Escape the ordinary with this exciting 10-day road trip through Italy. Explore diverse landscapes, discover lively cities, and prepare for an unforgettable journey!

This perfectly planned road trip itinerary takes you through some of the best places to see in Italy. You will spend 3 nights in Genoa, 1 night in La Spezia, 2 nights in Florence, 1 night in San Gimignano, and 2 nights in Rome. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Italy. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have you covered.

Upon arriving in Genoa, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Italy on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Italy. Trevi Fountain and Colosseum are just a couple of the bucket-list attractions that await your discovery. Marvel at the remarkable Pantheon, learn more about the unique Piazza Navona, and immerse yourself in the vibrant atmosphere of St. Peter's Basilica.

As you hit the open road and drive through Genoa, Corniglia, Manarola, Riomaggiore, La Spezia, Pisa, Florence, Siena, San Gimignano, Rome, and Orvieto, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Italy. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Italy.

Throughout your road trip in Italy, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Italy.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodations, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in Italy fill up quickly, so book your spot early. Select a date and start planning your road trip in Italy today!

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Driver’s age is 30 - 65
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Pick-up: 10:00
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Day 1

Day 1

  • Genoa - Arrival day
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  • piazza De Ferrari
  • More

Say hello to Genoa! Your exciting road trip through Italy is just about to start. Navigating the top places to see in the region is a breeze with a car. The rental vehicle of your choice will be ready for pickup upon your arrival in the city. You will stay in Genoa for 2 nights before you continue your adventure!

Genoa is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out Piazza De Ferrari, or just taking a stroll in the city center. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

When you're ready for some downtime, make your way to your chosen hotel. Check-in typically starts between 2 and 4 PM in Genoa. Make yourself at home and unwind before heading out again.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Genoa, it's often a good idea to reserve a table in advance.

Make sure to reserve a table at 7 Sensi cucina decontaminata, an iconic dining spot in Genoa. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Alla Lunga Ristorante, a popular restaurant in Genoa. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of Grand Hotel Savoia, a hidden gem nestled in Genoa. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

Extend your evening after a delightful meal by visiting Scurreria Beer & Bagel, which offers the perfect atmosphere for a night out. Moreover, La Lepre is another popular option for a drink or two. Likewise, Bar Pisacane Iii also provides a great ambiance for reminiscing about the day and raising a toast to your vacation.

Raise a toast to the start of your 10-day road trip in Italy!

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Day 2

Day 2

  • Genoa
  • More

Drive 13 km, 1 hour 13 min

  • Lighthouse of Genoa
  • Galata - Museo del mare
  • Via Garibaldi
  • Palazzo Podestà
  • Aquarium of Genoa
  • porto antico
  • More

Day 2 of your road trip will take you to the best attractions Genoa has to offer. Cherish the 1 night you have left in the city and use the provided itinerary to discover what to see in Genoa.

Lighthouse Of Genoa is an ideal stop early in the day. This curiosity-inducing lighthouse is a must-visit in the city. When you’re ready for your next discovery, continue to Galata Museo Del Mare (complex), which may be one of the most eye-catching places you will experience today.

One of the best things about exploring Genoa on a self-guided tour is that you set the pace. There’s plenty of time for detours and discovering hidden gems. When you’re ready for your next stop, make your way to Via Garibaldi, a beloved street in the city. If you’re up for more discoveries, don’t forget to reserve some time for Palazzo Podestà and Aquarium Of Genoa. End your day with a visit to Porto Antico, an interesting public square that’s sure to leave a lasting impression.

Don’t forget to check out all the popular tours and experiences you can add to your travel plans in Italy. You can explore and select activities under each day of your itinerary.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Genoa, it's often a good idea to reserve a table in advance.

Treat yourself to a delicious dinner at Zeffirino, an excellent option for tonight's dining. Looking for something different? Trattoria Vegia Zena offers a tantalizing alternative with its diverse menu. And don’t miss Trattoria delle Grazie. Known for great service, it’s a fantastic choice for tonight in Genoa.

Relax and look forward to more memorable moments to come!

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Day 3

Day 3

  • Genoa
  • La Spezia
  • More

Drive 132 km, 3 hours 14 min

  • Cinque Terre National Park
  • Manarola Overlook Viewpoint
  • Riomaggiore
  • Castle of Riomaggiore
  • More

Experience an unparalleled adventure on day 3 of your road trip in Italy. This exciting part of your journey invites you to discover the renowned landmarks in 3 places, which are Corniglia, Manarola, and Riomaggiore. At the end of the day, you will retreat to the hotel of your choice in La Spezia, where will spend 1 night.

Check out the well-known national park, Cinque Terre National Park. Afterward, continue to Manarola Overlook Viewpoint, an observation deck every traveler should visit. As you explore Genoa’s charming streets, take in the lively atmosphere and get to know the character of the village.

Next, make your way to Riomaggiore. This curiosity-inducing point of interest is an essential stop. Following that, head to Castle Of Riomaggiore, another must-visit site that will enhance your experience.

When you’re done exploring for the day, you’ll drive to your hotel in La Spezia. Check in and relax before you head out to tour the city.

La Spezia is a place where the culinary landscape is as diverse as its attractions. So before the day ends, treat your palate to a taste of local cuisine at one of the best restaurants in La Spezia.

Have a fantastic dining experience at The Colombaio Park, a highly recommended choice for tonight's dinner.

As the day draws to a close, take a moment to unwind and prepare for the next exciting chapter of your road trip in Italy.

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Day 4

Day 4

  • La Spezia
  • Florence
  • More

Drive 171 km, 2 hours 42 min

  • Leaning Tower of Pisa
  • Angelo Caduto
  • Pisa Cathedral
  • Piazza del Duomo, Pisa
  • Campo santo
  • More

On day 4 of your road trip in Italy, your travel plans include 1 stop at the most scenic, wondrous, and interesting places in the region. Pisa are on today's agenda. In the evening, you’ll end up in Florence, where you will stay for 2 nights.

Catch Leaning Tower Of Pisa before the crowds roll in. This picture-perfect monument is sure to ignite your curiosity.

In between sights, stop by local stores, picturesque photo spots, and small eateries. When you’re ready for your next attraction, proceed to Pisa Cathedral, a worthwhile church. For a change of scene, check out Piazza Del Duomo, Pisa, known for its breathtaking features. We also recommend visiting Campo Santo. This cemetery is a must for anyone looking to experience the city to the fullest.

After soaking up all the sights on today's itinerary, you'll be ready to head to your accommodation in Florence. Florence offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Florence. Enjoy a relaxing evening as you savor delicious local cuisine.

Make sure to reserve a table at Ristorante Oliviero 1962, an iconic dining spot in Florence. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Di Poneta Novoli, a popular restaurant in Florence. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of Caffe San Firenze, a hidden gem nestled in Florence. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

Extend your evening after a delightful meal by visiting Manifattura, which offers the perfect atmosphere for a night out. Moreover, Se·sto On Arno Rooftop Bar is another popular option for a drink or two. Likewise, Il Vinile also provides a great ambiance for reminiscing about the day and raising a toast to your vacation.

Relax and look forward to more memorable moments to come!

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Day 5

Day 5

  • Florence
  • More

Drive 2 km, 36 min

  • Basilica of Santa Croce in Florence
  • Uffizi Gallery
  • Ponte Vecchio
  • Palazzo Vecchio
  • piazza della Signoria
  • Cathedral of Santa Maria del Fiore
  • More

On day 5 of your road trip, you will have an entire day to discover what to see in Florence. You’ll stay in Florence for 1 night.

Let Basilica Of Santa Croce In Florence set the tone for the day. Spend some time admiring this heritage-rich church before continuing your journey. Uffizi Gallery is your next stop. This famous art gallery is one of the best-rated sights in Florence.

Consider grabbing some lunch or a light snack to keep your energy going. Beyond the above-mentioned attractions, today is also the perfect time to visit Ponte Vecchio. This enchanting historical landmark is a sight to behold. To round off your sightseeing experience, visit Palazzo Vecchio and Piazza Della Signoria. If time allows, end your day with Cathedral Of Santa Maria Del Fiore, a history-steeped church that offers a memorable conclusion to your exploration.

Don’t forget to check out all the popular tours and experiences you can add to your travel plans in Italy. You can explore and select activities under each day of your itinerary.

After a day of adventure, treat yourself to an exquisite dinner at one of Florence's best restaurants.

Enjoy a lovely meal at Ditta Artigianale, a top-rated place to have dinner tonight. Alternatively, if your taste buds call for something different, Trattoria Da Burde is another top choice with a popular menu. You could also check for a table at Casa Toscana. As an establishment that consistently gains high praises from customers, it’s an ideal choice in Florence tonight.

Explore the vibrant nightlife at Bar 50 Rosso after your meal, a hub for lively evenings and memorable moments. Or, head to Bitter Bar for a great selection of flavorful drinks and a charming setting. Furthermore, Archea Brewery is perfect for those looking to extend their night with a touch of local flavor.

Savor another day of unforgettable experiences in Italy!

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Day 6

Day 6

  • Florence
  • San Gimignano
  • More

Drive 122 km, 2 hours 19 min

  • Siena Cathedral
  • piazza del Campo
  • Tower of Mangia
  • Chiesa di Sant'Agostino
  • Town Hall, Picture Gallery and Great Tower
  • Piazza del Duomo, San Gimignano
  • More

Dive into day 6 of your remarkable road trip in Italy. Today you'll explore 2 destinations, including Siena and San Gimignano. At the end of the day, you’ll unwind at one of the finest accommodations in San Gimignano, where you'll spend 1 night.

Experience Siena Cathedral, a locally renowned church in the city. Then, head to Piazza Del Campo and soak in the ambiance of this UNESCO world heritage-listed public square.

There are many interesting places to see in Florence, and when you are ready for more, go to Tower Of Mangia. This is one of the city’s most intriguing awe-inspiring spots of interest. After exploring the monument, visit the locally appreciated Chiesa Di Sant'agostino. Not far away, you'll also find Palazzo Comunale, Pinacoteca, Torre Grossa. This museum is a historic highlight in Florence. Before wrapping up your self-guided sightseeing tour, head to Piazza Del Duomo, a beloved public square in the city.

At the end of the day, you will drive to San Gimignano, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

After a day of adventure, treat yourself to an exquisite dinner at one of San Gimignano's best restaurants.

Say good night to San Gimignano and look forward to another great day of your road trip in Italy!

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Day 7

Day 7

  • San Gimignano
  • Rome
  • More

Drive 281 km, 4 hours 6 min

  • Castel Sant'Angelo
  • Spanish Steps
  • Piazza di Spagna
  • Trevi Fountain
  • Altare della Patria
  • Circus Maximus
  • More

On day 7 of your exciting self-drive vacation in Italy, you’ll soak in the magnificence of 1 destination, including Rome. When you’re not sightseeing, take time to relax at your chosen hotel in Rome, where you’ll be staying for 2 nights.

Whatever your travel style is, Castel Sant'angelo is an essential stop in San Gimignano. This astonishing castle provides an insightful glimpse into the city's identity. Next, discover Spanish Steps, a romantic public square, promising a delightful encounter.

Continue your sightseeing with a visit to Piazza Di Spagna, a wondrous public square. When you’re done, don’t forget to make a stop at the timeless Trevi Fountain. Not far away from the monument, you will find the picture-perfect Circus Maximus, perfect for a quick visit. Round off your day at Altare Della Patria, another gem in San Gimignano with culturally significant features to discover.

When you’re done exploring for the day, you’ll drive to your hotel in Rome. Check in and relax before you head out to tour the city.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Rome, it's often a good idea to reserve a table in advance.

Treat yourself to a delicious dinner at La Bottega Roma, an excellent option for tonight's dining. Looking for something different? Pasta In Corso offers a tantalizing alternative with its diverse menu. And don’t miss Trattoria Vecchia Roma. Known for great service, it’s a fantastic choice for tonight in Rome.

After savoring a delicious meal, step into the vibrant nightlife at La Botticella Of Poggi Giovanni, where the evening is just getting started. In the same way, Almalu Trastevere offers a unique charm perfect for experiencing the local bar scene in Rome. Bar Viminale Di Pepi Maurilio is another top-recommended bar that is sure to get you into the mood for some dancing and celebrating.

Head back to your accommodation in Rome and get some rest to prepare for another magical day of your road trip in Italy.

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Day 8

Day 8

  • Rome
  • More

Drive 11 km, 1 hour 1 min

  • St Peter's Basilica
  • Roman Forum
  • Colosseum
  • Pantheon
  • Piazza Navona
  • Trastevere
  • More

On day 8 of your road trip, you’ll start and end your day in Rome, where you have 1 night left to stay.

Set aside time today to explore Trastevere, a standout neighborhood that reflects the essence of the city. While you're there, you'll also be within reach of some of the city's top landmarks, making it easy to maximize your day.

One of the most iconic attractions included on the itinerary is St. Peter's Basilica. Then, take a leisurely stroll to Roman Forum and learn what makes this historic archeological site unique.

Throughout the day, make sure to take breaks to appreciate the surroundings. Next up, visit the iconic Colosseum. After exploring the archeological site, head to Pantheon. This iconic monument is a highlight in Rome. As your day continues, stop by Piazza Navona, known for its visually striking features.

When you’re done exploring for the day, you’ll return to Rome and your accommodation.

Rome is a place where the culinary landscape is as diverse as its attractions. So before the day ends, treat your palate to a taste of local cuisine at one of the best restaurants in Rome.

Enjoy a delicious meal at RomAntica, a highly-rated dining destination in Rome. If you're eager to try something different, consider Coso Ristorante, another top spot with a tantalizing menu. You might also want to secure a reservation at DEROMA - Farine Romane. With a reputation for consistently satisfying customers, it’s an excellent choice to enhance your stay in Rome this evening.

Continue your lively evening at Sant' Eustachio Caffè, a perfect place for winding down or revving up the night, depending on which mood you’re in. Yellowsquare Rome is another excellent bar that offers a great selection of drinks to suit any mood. If you prefer to go somewhere else, Caffè Portofino ensures a night out tailored to your taste.

As the day draws to a close, take a moment to unwind and prepare for the next exciting chapter of your road trip in Italy.

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Day 9

Day 9

  • Rome
  • Genoa
  • More

Drive 519 km, 6 hours 15 min

  • Well of St Patrick
  • Orvieto Cathedral
  • Orvieto subterranea
  • Torre del Moro Orvieto
  • Pozzo della Cava
  • More

Your itinerary for day 9 of your road trip in Italy includes 1 stop and features some of the highlights of Orvieto. At the end of the day, enjoy the comforts of a top-rated hotel in Genoa, where you'll spend 1 night.

Visiting Well Of St. Patrick is always a good idea. This captivating monument is a place that is appreciated by travelers and locals alike. Next, immerse yourself in the inviting wonders of Orvieto Cathedral, a must-see church in the village.

Consider stopping for a small bite to eat or a drink at a local eatery to keep your energy going. When you’re ready, continue your discovery with a visit to Orvieto Underground. This locally appreciated cave system offers an enriching experience. For a change of pace, head to Torre Del Moro Orvieto, where you can take in stunning features. Conclude your self-guided sightseeing tour with a visit to Pozzo Della Cava. These sights offer a fulfilling end to a perfect day.

After soaking up all the sights on today's itinerary, you'll be ready to head to your accommodation in Genoa. Genoa offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

Indulge in a memorable dining experience at one of Genoa's most popular restaurants, and connect with friendly locals for a true cultural experience.

Savor the flavors at Osteria Sant'Ilario, a top pick for dinner tonight. Alternatively, La Cialtroneria beckons with its unique menu offerings. Also, consider Manhattan Bar. With its consistent customer satisfaction, it’s an excellent option for dining in Genoa tonight.

Savor another day of unforgettable experiences in Italy!

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Day 10

Day 10

  • Genoa - Departure day
  • More
  • AMT GENOVA - Ferrovia Genova Casella
  • More

Day 10 of your road trip in Italy is your departure day. This is your chance to catch a last glimpse of Genoa before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

If you're up for some more sightseeing, we recommend visiting Amt Genova - Ferrovia Genova Casella, a breathtaking heritage railway before you head out.

For a last-minute shopping spree in Genoa, Via XX Settembre is nearby. Enjoy a variety of retail stores, dining options, and essential services in one convenient location.

Before you conclude your road trip in Italy, drop by another restaurant for a last chance at a memorable dining experience in Genoa.

You’ll then say farewell to Genoa. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Italy!

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Shortly after booking, you’ll receive your full itinerary, including schedules, locations, and everything you need for a stress-free trip.
Personalize your itinerary
Each package includes a professionally crafted itinerary you can tailor to your travel style. A dedicated travel expert will make sure every detail fits your needs perfectly.
Easily make changes
Need to update plans? No problem. Whether before your trip or mid-journey, we’re just seconds away to help with quick adjustments.
Enjoy seamless planning
With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.
Explore with confidence
From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.
Secure your spot
Confirm your package instantly and lock in the best rate with secure payment and guaranteed availability.
Get instant confirmation
Shortly after booking, you’ll receive your full itinerary, including schedules, locations, and everything you need for a stress-free trip.
Personalize your itinerary
Each package includes a professionally crafted itinerary you can tailor to your travel style. A dedicated travel expert will make sure every detail fits your needs perfectly.
Easily make changes
Need to update plans? No problem. Whether before your trip or mid-journey, we’re just seconds away to help with quick adjustments.
Enjoy seamless planning
With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.
Explore with confidence
From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.

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Your trip is protected, personalized, and priced right. No surprises, no stress.

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