10-Day Italy Self-Drive Road Trip With Itinerary from Genoa to La Spezia, Florence, San Gimignano, and Rome

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Escape the ordinary with this exciting 10-day road trip through Italy. Explore the diverse landscapes, lively cities, and beyond. Pack your bags, hit the road, and prepare for an unforgettable journey!

This perfectly planned road trip itinerary in Italy takes you through some of the best places to see in the country. You will spend 3 nights in Genoa, 1 night in La Spezia, 2 nights in Florence, 1 night in San Gimignano, and 2 nights in Rome. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Italy. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have got you covered.

Upon arriving in Genoa, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Italy on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Italy. Trevi Fountain and Colosseum are just a couple of the bucket-list attractions that await your discovery. Marvel at the remarkable Pantheon, learn more about the unique Piazza Navona, and immerse yourself in the vibrant atmosphere of St. Peter's Basilica.

As you hit the open road and drive through Genoa, Corniglia, Manarola, Riomaggiore, La Spezia, Pisa, Florence, Siena, San Gimignano, Rome, and Orvieto, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Italy. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Italy.

Throughout your road trip in Italy, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Italy.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodation, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in Italy fill up quickly, so book your spot early. Select a date and start planning your road trip in Italy today!

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Driver’s age is 30 - 65
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Itinerary summary

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Days
Destination
Attractions
Overnight
Day
City & Overnight
Attractions
piazza De Ferrari
Lighthouse of GenoaGalata - Museo del mareVia GaribaldiPalazzo PodestàAquarium of Genoaporto antico
Cinque Terre National ParkManarola Overlook ViewpointRiomaggioreCastle of Riomaggiore
Leaning Tower of PisaAngelo CadutoPisa CathedralPiazza del Duomo, PisaCampo santo
Basilica of Santa Croce in FlorenceUffizi GalleryPonte VecchioPalazzo Vecchiopiazza della SignoriaCathedral of Santa Maria del Fiore
Siena Cathedralpiazza del CampoTower of MangiaChiesa di Sant'AgostinoTown Hall, Picture Gallery and Great TowerPiazza del Duomo, San Gimignano

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Day 1

Day 1

  • Genoa - Arrival day
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  • piazza De Ferrari
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Your road trip adventure in Italy begins as soon as you reach Genoa and pick up your car. You’ll stay in Genoa for 2 nights and explore the best things to see and do, sample the local cuisine, and choose from a curated selection of the best hotels and places to stay in the city.

Genoa is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out Piazza De Ferrari, or just taking a stroll in the city center. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

Find your way to your hotel in Genoa. We recommend choosing a hotel in a central location for easy exploring. Check-in typically starts between 2 and 4 PM at hotels in Italy. Settle in and make plans for the evening.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Genoa, it's often a good idea to reserve a table in advance.

Have a fantastic dining experience at 7 Sensi cucina decontaminata, a highly recommended choice for tonight's dinner. If you're looking to mix things up, Alla Lunga Ristorante offers an enticing alternative with its varied menu. Additionally, Grand Hotel Savoia is worth considering. Renowned for satisfying diners, it’s an ideal option for tonight in Genoa.

Continue the enjoyment post-dinner at Scurreria Beer & Bagel, a cherished local gathering spot renowned for its welcoming atmosphere. Similarly, La Lepre offers a vibrant space for indulging in well-crafted drinks and engaging conversation. You may also want to check out Bar Pisacane Iii. This bar is a favorite among both locals and visitors looking for a delightful evening out filled with laughter and fun.

Raise a toast to the start of your 10-day road trip in Italy!

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Day 2

Day 2

  • Genoa
  • More

Drive 13 km, 1 hour 13 min

  • Lighthouse of Genoa
  • Galata - Museo del mare
  • Via Garibaldi
  • Palazzo Podestà
  • Aquarium of Genoa
  • porto antico
  • More

Day 2 of your road trip across Italy promises a magnificent time exploring Genoa. You have 1 night left in Genoa. Take the opportunity to experience more of the best attractions and activities in the city.

Bring your curiosity for today’s adventure around Genoa. Some of the city’s most loved attractions await! Lighthouse Of Genoa is the perfect place to start. This lighthouse is one of the most locally appreciated places to visit in Genoa. Next, head to Galata Museo Del Mare (complex), an increasingly popular maritime museum, known for its eye-catching features.

In between the sights, don’t hesitate to take small detours to explore local stores and eateries. When you’re ready to continue your adventure, head to Via Garibaldi. This romantic street is a highly recommended experience. Nearby, you'll also find Palazzo Podestà and Aquarium Of Genoa. Visit these for an interesting touch to your journey. Finish the day with a visit to Porto Antico, a visually striking public square in Genoa.

Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.

Experience shopping bliss at Genoa as you explore Porto Antico. Take a leisurely stroll through unique and shops, where local treasures are waiting to be found. Beyond shopping, Porto Antico offers more options, including unique attractions, key services, and vibrant events.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Genoa. Enjoy a relaxing evening as you savor delicious local cuisine and reflect on the day's adventures.

Treat yourself to a delightful dinner at Zeffirino, highly recommended for tonight's dining. Or, if you're feeling adventurous, why not try Trattoria Vegia Zena? It's another excellent option with a diverse menu. Consider reserving a table at Trattoria delle Grazie as well. Known for its consistent customer satisfaction, it’s an ideal pick for tonight in Genoa.

Celebrate another amazing day of your road trip adventure in Italy!

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Day 3

Day 3

  • Genoa
  • La Spezia
  • More

Drive 132 km, 3 hours 14 min

  • Cinque Terre National Park
  • Manarola Overlook Viewpoint
  • Riomaggiore
  • Castle of Riomaggiore
  • More

Dive into day 3 of your remarkable road trip in Italy. Today you will explore Corniglia, Manarola, and Riomaggiore, where you will have the opportunity to experience all the top things to see and do. At the end of the day, you’ll unwind at one of the finest accommodations in La Spezia. You’ll stay here for 1 night.

Start your day with a visit to Cinque Terre National Park. This popular national park is a must-visit in the village. When you’re ready for your next discovery, continue to Manarola Overlook Viewpoint, which may be one of the most idyllic places you will experience today.

One of the best things about exploring Genoa on a self-guided tour is that you set the pace. There’s plenty of time for detours and discovering hidden gems. When you’re ready for your next stop, make your way to Riomaggiore, an intriguing sightseeing destination in the village. If you’re up for more discoveries, don’t forget to reserve some time for Castle Of Riomaggiore.

When you’re done exploring for the day, you’ll drive to your hotel in La Spezia. Check in and spend some time relaxing before you head out to tour the city.

As dinnertime approaches, it's time to head out for a bite to eat in La Spezia. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.

Make sure to reserve a table at The Colombaio Park, an iconic dining spot in La Spezia. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world.

Savor another day of unforgettable experiences in Italy!

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Day 4

Day 4

  • La Spezia
  • Florence
  • More

Drive 171 km, 2 hours 42 min

  • Leaning Tower of Pisa
  • Angelo Caduto
  • Pisa Cathedral
  • Piazza del Duomo, Pisa
  • Campo santo
  • More

On day 4 of your road trip in Italy, you will get a true taste of the freedom a self-drive vacation in Europe entails. Today’s travel plans include stops at the most scenic, wondrous, and interesting places in Pisa. In the evening, you’ll end up in Florence, where you will stay for 2 nights.

Start your adventure at Leaning Tower Of Pisa. This world-famous monument is a place that is appreciated by travelers and locals alike.

Consider stopping for a small bite to eat or a drink at a local eatery to keep your energy going. When you’re ready, continue your discovery with a visit to Pisa Cathedral. This locally appreciated church offers an enriching experience. For a change of pace, head to Piazza Del Duomo, Pisa, where you can take in UNESCO world heritage-designated features. Conclude your self-guided sightseeing tour with a visit to Campo Santo. These sights offer a fulfilling end to a perfect day.

At the end of the day, you will drive to Florence, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

Indulge in a memorable dining experience at one of Florence's most popular restaurants, and connect with friendly locals for an authentic adventure.

Treat yourself to a delicious dinner at Ristorante Oliviero 1962, an excellent option for tonight's dining. Looking for something different? Di Poneta Novoli offers a tantalizing alternative with its diverse menu. And don’t miss Caffe San Firenze. With its reputation for pleasing customers, it’s a fantastic choice for tonight in Florence.

Round off your dining experience by visiting Manifattura, a prime location for a drink. Alternatively, explore the distinctive characteristics of Se·sto On Arno Rooftop Bar, a bar catering to every mood and preference. Il Vinile likewise offers a unique atmosphere, perfect for a memorable night out.

Head back to your accommodation in Florence and get some rest in preparation for another magical day of your road trip in Italy!

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Day 5

Day 5

  • Florence
  • More

Drive 2 km, 36 min

  • Basilica of Santa Croce in Florence
  • Uffizi Gallery
  • Ponte Vecchio
  • Palazzo Vecchio
  • piazza della Signoria
  • Cathedral of Santa Maria del Fiore
  • More

Day 5 offers a multitude of experiences. You will stay in Florence for 1 night more, offering you enough time to explore at a relaxed pace.

Get ready for an exciting day in Florence. Today’s sightseeing agenda includes a church, an art gallery, a historical landmark, a palace, a public square and much more! Begin your adventure at Basilica Of Santa Croce In Florence. This is a captivating church you should not miss. Another must-see is Uffizi Gallery, a widely recognized art gallery in Florence.

When you’re ready for the next sight, head to Ponte Vecchio. From there, take a leisurely stroll to Palazzo Vecchio, another of the city’s popular attractions. We recommend continuing your self-guided tour at Piazza Della Signoria, a visually striking place of interest in the city. If time allows, add Cathedral Of Santa Maria Del Fiore to your itinerary. This astonishing church offers the perfect finishing touch to your day in Florence.

Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Florence. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Treat yourself to a delicious dinner at Ditta Artigianale, an excellent option for tonight's dining. Looking for something different? Trattoria Da Burde offers a tantalizing alternative with its diverse menu. And don’t miss Casa Toscana. With its reputation for pleasing customers, it’s a fantastic choice for tonight in Florence.

After enjoying a delightful dinner, why not delve into the vibrant local bar scene? You might want to spend the evening at Bar 50 Rosso, a well-loved spot among locals and tourists. Or, head to Bitter Bar. This bar boasts a welcoming environment that is perfect for winding down. You could also continue your night at Archea Brewery, another top-rated place in the area.

Get a good night's sleep and look forward to another great day on the road in Italy!

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Day 6

Day 6

  • Florence
  • San Gimignano
  • More

Drive 122 km, 2 hours 19 min

  • Siena Cathedral
  • piazza del Campo
  • Tower of Mangia
  • Chiesa di Sant'Agostino
  • Town Hall, Picture Gallery and Great Tower
  • Piazza del Duomo, San Gimignano
  • More

On day 6 of your exciting self-drive vacation in Italy, you’ll soak in the magnificence of 2 destinations, Siena and San Gimignano. When you’re not sightseeing, take time to relax at your selected hotel in San Gimignano, where you’ll be staying for 1 night.

Get ready to discover some of the most iconic wonders in Florence, including a church, a public square, a monument, a museum and much more! Start your day at Siena Cathedral. This visually striking church is a locally renowned place to see in Florence. Then, wander over to Piazza Del Campo. If visually striking sites excite you, this public square will be right up your alley. Nearby, you’ll also find Tower Of Mangia. This UNESCO world heritage-designated monument is a favorite among visitors.

Florence offers plenty to explore, ensuring every moment of your visit is filled with excitement and discovery. If you're up for more, Chiesa Di Sant'agostino is a frequently visited spot in the city that will captivate you with its unique charm. When you’re done at the church, don’t forget to check out the UNESCO world heritage-designated Palazzo Comunale, Pinacoteca, Torre Grossa. Take a moment to appreciate the fascinating details of this worthwhile museum. Wrap up your self-guided tour of Florence's top attractions with a visit to Piazza Del Duomo.

After soaking up all the sights of today's itinerary, you'll be ready to head in the direction of your accommodation in San Gimignano. San Gimignano offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in San Gimignano. Enjoy a relaxing evening as you savor delicious local cuisine and reflect on the day's adventures.

Take some time to reflect on your day and savor another beautiful night in Italy.

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Day 7

Day 7

  • San Gimignano
  • Rome
  • More

Drive 281 km, 4 hours 6 min

  • Castel Sant'Angelo
  • Spanish Steps
  • Piazza di Spagna
  • Trevi Fountain
  • Altare della Patria
  • Circus Maximus
  • More

Embark on another extraordinary experience on day 7 of your road trip in Italy. Today, you will make 1 stop and experience some of the highlights of Rome. At the end of the day, you will enjoy the comforts of a top-rated hotel in Rome, which will be your home away from home for 2 nights.

San Gimignano is home to plenty of attractions that offer fun adventures, romantic experiences, and breathtaking views! Start at Castel Sant'angelo, an astonishing castle that is worthwhile a visit in the city. Nearby, you’ll find Spanish Steps, enchanting visitors with its enchanting appeal. Continue your exploration at Piazza Di Spagna. This public square is one of the city’s most wondrous spots.

Enjoy the freedom of exploring San Gimignano at your own pace and find hidden gems along the way. If you want to see more picture-perfect spots, make sure to visit Trevi Fountain. After exploring the monument, head to the captivating Altare Della Patria. Lastly, wrap up today’s self-guided sightseeing tour with a visit to Circus Maximus, a place of picture-perfect interest in San Gimignano.

When you’re done exploring for the day, you’ll drive to your hotel in Rome. Check in and spend some time relaxing before you head out to tour the city.

After a day of adventure, treat yourself to an exquisite dinner at one of Rome's best restaurants.

Treat yourself to a delightful dinner at La Bottega Roma, highly recommended for tonight's dining. Or, if you're feeling adventurous, why not try Pasta In Corso? It's another excellent option with a diverse menu. Consider reserving a table at Trattoria Vecchia Roma as well. Known for its consistent customer satisfaction, it’s an ideal pick for tonight in Rome.

Following your dinner, dive into the local bar culture at La Botticella Of Poggi Giovanni. Enjoy this evening's relaxed ambiance with delightful drinks. Alternatively, go to Almalu Trastevere, the perfect place for those looking to experience the best of the nightlife. Similarly, Bar Viminale Di Pepi Maurilio provides excellent drinks and a great atmosphere, ensuring a memorable night out.

As the day draws to a close, take a moment to unwind and prepare for the next exciting chapter of your road trip in in Italy.

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Day 8

Day 8

  • Rome
  • More

Drive 11 km, 1 hour 1 min

  • St Peter's Basilica
  • Roman Forum
  • Colosseum
  • Pantheon
  • Piazza Navona
  • Trastevere
  • More

On day 8 of your road trip, you’ll start and end your day in Rome, but spend part of the day exploring places of interest outside the immediate city. On today's itinerary, you'll find attractions in Vatican City and Rome. You still have 1 night left in Rome.

Trastevere is one of the highlights of today. Take your time exploring this iconic neighborhood in Vatican City, which offers a perfect blend of history and culture. Plus, it's close to many must-see landmarks in the city.

Today's adventure in Rome promises more breathtaking discoveries and enriching experiences! Begin at St. Peter's Basilica. Then, enjoy Roman Forum, another historic attraction that never fails to captivate visitors. Next, head over to Colosseum, one of the city’s most globally renowned attractions, known for its picture-perfect features.

If you’re looking for more, spend time soaking in the atmosphere of Pantheon. This heritage-rich monument is frequented by locals and tourists alike. To complete your memorable day, make sure to visit Piazza Navona, a wondrous public square, and take a stroll around the area.

When you’re done exploring the area’s best attractions, you’ll drive back to your accommodation in Rome.

Indulge in a memorable dining experience at one of Rome's most popular restaurants, and connect with friendly locals for an authentic adventure.

Enjoy a delicious meal at RomAntica, a highly-rated dining destination in Rome. If you're eager to try something different, consider Coso Ristorante, another top spot with a tantalizing menu. You might also want to secure a reservation at DEROMA - Farine Romane. With a reputation for consistently satisfying customers, it’s an excellent choice to enhance your stay in Rome this evening.

After your meal, keep the night alive at a bar like Sant' Eustachio Caffè, known for its lively atmosphere. Yellowsquare Rome is another top recommendation that provides the perfect setting with well-crafted drinks and a welcoming ambiance. Similarly, Caffè Portofino offers an excellent atmosphere for those looking to amp up the evening.

Head back to your accommodation in Rome and get some rest in preparation for another magical day of your road trip in Italy!

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Day 9

Day 9

  • Rome
  • Genoa
  • More

Drive 519 km, 6 hours 15 min

  • Well of St Patrick
  • Orvieto Cathedral
  • Orvieto subterranea
  • Torre del Moro Orvieto
  • Pozzo della Cava
  • More

Experience an unparalleled adventure on day 9 of your road trip in Italy. This exciting part of your journey invites you to discover the renowned landmarks in 1 vibrant destinations - Orvieto. After a day filled with exploration and new experiences, you will retreat to the hotel of your choice in Genoa. You will spend 1 night here for some well-deserved relaxation.

Brace yourself for today’s incredible lineup of attractions in Rome, featuring family-friendly attractions, breathtaking views, and picturesque spots. Start at Well Of St. Patrick, an interesting monument in the village. Then, head to Orvieto Cathedral and soak in the ambiance of this history-steeped church.

There are many interesting places to see in Rome, and when you are ready for more, go to Orvieto Underground. This is one of the village’s most intriguing instagrammable spots of interest. After exploring the cave system, visit the beloved Torre Del Moro Orvieto. Not far away, you'll also find Pozzo Della Cava. This cave is a standout highlight in Rome.

At the end of the day, you will drive to Genoa, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Genoa. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Savor the flavors at Osteria Sant'Ilario, a top pick for dinner tonight. Alternatively, La Cialtroneria beckons with its unique menu offerings. Also, consider Manhattan Bar. With its consistent customer satisfaction, it’s an excellent option for dining in Genoa tonight.

Raise your glass to another unforgettable day in Italy!

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Day 10

Day 10

  • Genoa - Departure day
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  • AMT GENOVA - Ferrovia Genova Casella
  • More

Day 10 of your road trip in Italy is your departure day. This is your chance to catch a last glimpse of Genoa before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

If you're up for some more sightseeing, begin at Amt Genova - Ferrovia Genova Casella. This locally appreciated heritage railway is a popular place to see in the city.

Maximize your last day in Italy and go on a shopping spree in Genoa’s shopping center, the lively Via Garibaldi. Browse for souvenirs to remind you of your wonderful journey in Italy.

Before you conclude your road trip in Italy, drop by another restaurant for a last chance at a memorable dining experience in Genoa.

You’ll then say farewell to Genoa. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Italy!

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