10-Day Italy Self-Drive Road Trip With Itinerary from Genoa traveling east to Florence, Siena, and Rome

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Photo of Sand beach in Camogli by Genoa, Italy.
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Experience the freedom of the open road in Italy as you embark on an unforgettable 10-day road trip! This experience caters to every traveler, featuring destinations like Genoa, Riomaggiore, Manarola, Corniglia, Pisa, Florence, Siena, San Gimignano, Montalcino, and Rome.

This perfectly planned road trip itinerary in Italy takes you through some of the best places to see in the country. You will spend 4 nights in Genoa, 2 nights in Florence, 2 nights in Siena, and 1 night in Rome. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Italy. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have got you covered.

Upon arriving in Genoa, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Italy on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Italy. Trevi Fountain and Colosseum are just a couple of the bucket-list attractions that await your discovery. Marvel at the remarkable Pantheon, learn more about the unique Piazza Navona, and immerse yourself in the vibrant atmosphere of St. Peter's Basilica.

As you hit the open road and drive through Genoa, Riomaggiore, Manarola, Corniglia, Pisa, Florence, Siena, San Gimignano, Montalcino, and Rome, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Italy. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Italy.

Throughout your road trip in Italy, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Italy.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodation, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in Italy fill up quickly, so book your spot early. Select a date and start planning your road trip in Italy today!

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Driver’s age is 30 - 65
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Itinerary summary

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Days
Destination
Attractions
Overnight
Day
City & Overnight
Attractions
piazza De Ferrari
Lighthouse of GenoaGalata - Museo del mareAquarium of Genoaporto anticoVia GaribaldiPiazza della Vittoria
RiomaggioreManarola Overlook ViewpointCinque Terre National Park
Knights' SquareLeaning Tower of PisaPisa CathedralPiazza del Duomo, PisaBattistero di San GiovanniCampo santo
Cathedral of Santa Maria del FiorePalazzo VecchioPonte VecchioUffizi GalleryBasilica of Santa Croce in Florencepiazzale Michelangelo
Fortezza MediceaTower of Mangiapiazza del CampoFacciatoneSiena CathedralPiazza del Duomo, San Gimignano

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Day 1

Day 1

  • Genoa - Arrival day
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  • piazza De Ferrari
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Your road trip adventure in Italy begins as soon as you reach Genoa and pick up your car. You’ll stay in Genoa for 3 nights and explore the best things to see and do, sample the local cuisine, and choose from a curated selection of the best hotels and places to stay in the city.

Genoa is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out Piazza De Ferrari, or just taking a stroll in the city center. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

As afternoon approaches, head to your chosen hotel in Genoa. Check-in typically starts around 2 to 4 PM at hotels in Italy. We recommend staying at a hotel in a central location for easy access to the best attractions, restaurants, and bars in the city.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Genoa, it's often a good idea to reserve a table in advance.

Enjoy a lovely dining experience at 7 Sensi cucina decontaminata, a popular restaurant in Genoa. This acclaimed establishment has earned the admiration of countless food lovers in the city. Alternatively, experience a taste of Genoa at Alla Lunga Ristorante, another great place to eat. With a menu designed to impress, it promises a journey of flavors that will leave you captivated. A third option to check out is the top-rated Grand Hotel Savoia. It’s yet another ideal choice to enhance your time in Genoa tonight.

After savoring a delicious meal, step into the vibrant nightlife at Scurreria Beer & Bagel, where the evening is just getting started. In the same way, La Lepre offers a unique charm perfect for experiencing the local bar scene in Genoa. Bar Pisacane Iii is another top-recommended bar that is sure to get you into the mood for some dancing and celebrating.

Raise a toast to the start of your 10-day road trip in Italy!

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Day 2

Day 2

  • Genoa
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Drive 15 km, 1 hour 20 min

  • Lighthouse of Genoa
  • Galata - Museo del mare
  • Aquarium of Genoa
  • porto antico
  • Via Garibaldi
  • Piazza della Vittoria
  • More

Day 2 of your road trip will take you to the best attractions Genoa has to offer. Cherish the 2 nights you have left in Genoa by discovering the best things there are to see and do in the city.

Discover a day packed with fun adventures, scenic views, and picturesque spots in Genoa. Begin your sightseeing with Lighthouse Of Genoa. This increasingly popular lighthouse is one of the top attractions in the city. Proceed to Galata Museo Del Mare (complex), another must-visit attraction.

As you wander through the inviting streets of Genoa, soak in the lively ambiance and take the opportunity to snap some photos. Next, head to Aquarium Of Genoa. This astonishing aquarium is a traveler-favorite. Not far away, you’ll find Porto Antico, another key site on your sightseeing itinerary. Via Garibaldi is yet another highly recommended place to visit nearby, offering plenty to discover for curious travelers. Conclude your day at Piazza Della Vittoria and uncover why it's recognized as one of the city's most increasingly popular attractions.

Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.

Indulge in a memorable dining experience at one of Genoa's most popular restaurants, and connect with friendly locals for an authentic adventure.

Savor the flavors at Zeffirino, a top pick for dinner tonight. Alternatively, Trattoria Vegia Zena beckons with its unique menu offerings. Also, consider Trattoria delle Grazie. With its consistent customer satisfaction, it’s an excellent option for dining in Genoa tonight.

Celebrate another amazing day of your road trip adventure in Italy!

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Day 3

Day 3

  • Genoa
  • More

Drive 240 km, 4 hours 21 min

  • Riomaggiore
  • Manarola Overlook Viewpoint
  • Cinque Terre National Park
  • More

Wake up to day 3 of your extraordinary road trip in Italy. With 1 night left in Genoa, we encourage you to seize the day and discover the unexplored beauty of the city’s surroundings!

Get ready for a day filled with family-friendly attractions, romantic experiences, and natural wonders in the charming village of Genoa. Your adventure starts at Riomaggiore, a frequently visited local hot spot. Another notable attraction to explore is Manarola Overlook Viewpoint.

After soaking in the highlights of these sights, take some time to wander Genoa's streets and immerse yourself in the local atmosphere. When you're ready to continue your sightseeing adventure, head to Cinque Terre National Park. This UNESCO world heritage-designated national park offers a fascinating experience that many visitors find memorable.

When you’re done exploring the area’s best attractions, you’ll drive back to your accommodation in Genoa.

As you explore more of Genoa, you'll discover that its culinary landscape is as diverse as its attractions. Whether you're craving traditional dishes bursting with local flavors or innovative creations that push the boundaries of taste, you're sure to find a dining experience that satisfies your cravings.

Enjoy a delicious meal at Osteria Sant'Ilario, a top-rated dining destination in Genoa. If you're in the mood to try something new, consider La Cialtroneria, another top spot with a mouthwatering menu. You might also want to secure a reservation at Manhattan Bar. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Genoa this evening.

Take some time to reflect on your day and savor another beautiful night in Italy.

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Day 4

Day 4

  • Genoa
  • Florence
  • More

Drive 263 km, 3 hours 47 min

  • Knights' Square
  • Leaning Tower of Pisa
  • Pisa Cathedral
  • Piazza del Duomo, Pisa
  • Battistero di San Giovanni
  • Campo santo
  • More

Experience an unparalleled adventure on day 4 of your road trip in Italy. This exciting part of your journey invites you to discover the renowned landmarks in 1 vibrant destinations - Pisa. After a day filled with exploration and new experiences, you will retreat to the hotel of your choice in Florence. You will spend 2 nights here for some well-deserved relaxation.

Get ready for an exciting day in Genoa. Today’s sightseeing agenda includes a public square, a monument, a church, a cemetery and much more! Begin your adventure at Knights' Square. This is a beloved public square you should not miss. Another must-see is Leaning Tower Of Pisa, a world-famous monument in Genoa.

When you’re ready for the next sight, head to Pisa Cathedral. From there, take a leisurely stroll to Piazza Del Duomo, Pisa, another of the city’s timeless attractions. We recommend continuing your self-guided tour at Battistero Di San Giovanni, a grand place of interest in the city. If time allows, add Campo Santo to your itinerary. This increasingly popular cemetery offers the perfect finishing touch to your day in Genoa.

After soaking up all the sights of today's itinerary, you'll be ready to head in the direction of your accommodation in Florence. Florence offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

As dinnertime approaches, it's time to head out for a bite to eat in Florence. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.

Enjoy a lovely meal at Ristorante Oliviero 1962, a top-rated place to have dinner tonight. Alternatively, if your taste buds call for something different, Di Poneta Novoli is another top choice with a popular menu. You could also check for a table at Caffe San Firenze. As an establishment that gains consistently high praises from customers, it’s an ideal choice in Florence tonight.

After savoring a delicious meal, step into the vibrant nightlife at Manifattura, where the evening is just getting started. In the same way, Se·sto On Arno Rooftop Bar offers a unique charm perfect for experiencing the local bar scene in Florence. Il Vinile is another top-recommended bar that is sure to get you into the mood for some dancing and celebrating.

Raise your glass and celebrate another amazing day of your road trip in Italy!

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Day 5

Day 5

  • Florence
  • More

Drive 8 km, 1 hour 3 min

  • Cathedral of Santa Maria del Fiore
  • Palazzo Vecchio
  • Ponte Vecchio
  • Uffizi Gallery
  • Basilica of Santa Croce in Florence
  • piazzale Michelangelo
  • More

On day 5 of your road trip, you will have an entire day to explore Florence. You’ll stay in Florence for 1 night and discover all the best things to see and do in the area.

Brace yourself for today’s incredible lineup of attractions in Florence, featuring family-friendly attractions, romantic experiences, and scenic views. Start at Cathedral Of Santa Maria Del Fiore, a spectacular church in the city. Then, head to Palazzo Vecchio and soak in the ambiance of this enchanting palace.

There are many interesting places to see in Florence, and when you are ready for more, go to Ponte Vecchio. This is one of the city’s most iconic grand spots of interest. After exploring the historical landmark, visit the famous Uffizi Gallery. Not far away, you'll also find Basilica Of Santa Croce In Florence. This church is a photogenic highlight in Florence. Before wrapping up your self-guided sightseeing tour, head to Piazzale Michelangelo, a top-rated observation deck in the city.

Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.

As you explore more of Florence, you'll discover that its culinary landscape is as diverse as its attractions. Whether you're craving traditional dishes bursting with local flavors or innovative creations that push the boundaries of taste, you're sure to find a dining experience that satisfies your cravings.

Enjoy a lovely dining experience at Ditta Artigianale, a popular restaurant in Florence. This acclaimed establishment has earned the admiration of countless food lovers in the city. Alternatively, experience a taste of Florence at Trattoria Da Burde, another great place to eat. With a menu designed to impress, it promises a journey of flavors that will leave you captivated. A third option to check out is the top-rated Casa Toscana. It’s yet another ideal choice to enhance your time in Florence tonight.

Continue the enjoyment post-dinner at Bar 50 Rosso, a cherished local gathering spot renowned for its welcoming atmosphere. Similarly, Bitter Bar offers a vibrant space for indulging in well-crafted drinks and engaging conversation. You may also want to check out Archea Brewery. This bar is a favorite among both locals and visitors looking for a delightful evening out filled with laughter and fun.

Head back to your accommodation in Florence and get some rest in preparation for another magical day of your road trip in Italy!

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Day 6

Day 6

  • Florence
  • Siena
  • More

Drive 159 km, 3 hours 8 min

  • Fortezza Medicea
  • Tower of Mangia
  • piazza del Campo
  • Facciatone
  • Siena Cathedral
  • Piazza del Duomo, San Gimignano
  • More

Dive into day 6 of your remarkable road trip in Italy. Today you will explore Siena and San Gimignano, where you will have the opportunity to experience all the top things to see and do. At the end of the day, you’ll unwind at one of the finest accommodations in Siena. You’ll stay here for 2 nights.

Today’s agenda in Florence includes a monument, a public square, an observation deck, a church and much more! Fortezza Medicea (siena) is must-visit monument and a great starting point for the day. Next, continue your journey to Tower Of Mangia, an up-and-coming monument, located just a leisurely stroll away. Next, head to Piazza Del Campo, a visually striking public square, also available for your discovery today.

Each stop on today’s itinerary promises to leave you with lasting memories and a deeper appreciation for Florence. When you're ready, let your sightseeing route take you to the underrated Facciatone. If you’re looking for more, Siena Cathedral is also a popular attraction that is worthwhile a visit. Lastly, don’t miss Piazza Del Duomo, a place of grand interest in the city.

When you’re done exploring for the day, you’ll drive to your hotel in Siena. Check in and spend some time relaxing before you head out to tour the city.

After a day of adventure, treat yourself to an exquisite dinner at one of Siena's best restaurants.

Dine in style at Enoteca I Terzi, a top recommendation for dinner tonight. Or, for a change of pace, Ristorante Tar-Tufo boasts a menu that's sure to impress. Also, be sure to check out Antica Trattoria Papei. Known as a local hotspot, it’s a great choice for tonight in Siena.

Unwind after your meal by stepping into Meet Life Cafè. This venue is celebrated for its extensive drink selections and cozy vibes. Alternatively, Maudit Pub offers a dynamic and energetic atmosphere for a glass or two. Don’t overlook Bar Impero Siena, another top-rated bar in the area.

Get a good night's sleep and look forward to another great day on the road in Italy!

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Day 7

Day 7

  • Siena
  • More

Drive 84 km, 1 hour 54 min

  • Fortress of Montalcino
  • Piazza del Popolo
  • Church of Our Lady of Soccour
  • More

On day 7 of your road trip in Italy, you’ll start and end your day in Siena, but spend the day exploring what’s beyond the city. Since you will return to Siena for 1 night more, there’s no need to rush. Experience Montalcino to the fullest today with this curated day itinerary!

Today’s well-planned self-sightseeing route offers several fun adventures, romantic experiences, and breathtaking views. Whether you decide to explore Siena on foot, use public transport, or join a guided tour, there are a few attractions you don’t want to miss. Fortress Of Montalcino is the first of them. Spend some time admiring this romantic castle before continuing your journey. Piazza Del Popolo is your next stop. This up-and-coming public square is one of the best-rated sights in Siena.

Consider grabbing some lunch or a light snack to keep your energy going. Beyond the above-mentioned attractions, today is also the perfect time to visit Church Of Our Lady Of Soccour. This heritage-rich church is a sight to behold.

When you’re done exploring for the day, you’ll return to Siena and your accommodation.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Siena. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Have a fantastic dining experience at Osteria Quattro Venti, a highly recommended choice for tonight's dinner. If you're looking to mix things up, Fischi per Fiaschi offers an enticing alternative with its varied menu. Additionally, Osteria da Divo is worth considering. Renowned for satisfying diners, it’s an ideal option for tonight in Siena.

After your delicious meal, get a taste of the vibrant nightlife with a visit to Charlie Mixology Bar Di Aldinucci Riccardo, known for its inviting atmosphere. Bar Pinacoteca is another great option if you’re looking for a place to get the night started. Similarly, San Paolo Pub provides a great setting to enjoy the night away.

Relax and recharge in preparation for another adventurous day in Italy!

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Day 8

Day 8

  • Siena
  • Rome
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Drive 242 km, 3 hours 37 min

  • Colosseum
  • Roman Forum
  • Trevi Fountain
  • Pantheon
  • Piazza Navona
  • More

On day 8 of your exciting self-drive vacation in Italy, you’ll soak in the magnificence of 1 destination, Rome. When you’re not sightseeing, take time to relax at your selected hotel in Rome, where you’ll be staying for 1 night.

Today’s route brings family-friendly attractions, breathtaking views, and photo-friendly spots. The first attraction of today is Colosseum. This timeless archeological site is a respected place to see in Siena. Continue your discovery at Roman Forum, a breathtaking archeological site with stories to tell.

As you stroll around Siena, take in the distinct atmosphere and learn what makes this city so unique. Maximize your sightseeing with a visit to Trevi Fountain. This timeless monument offers a visually striking encounter with Siena. Next, make your way to Pantheon to add another highlight to your day. After that, visit Piazza Navona, a wondrous public square that’s sure to impress. Whether you decide to get entrance tickets for all attractions or you prefer admiring from a distance, amazing experiences await on this day in Siena.

At the end of the day, you will drive to Rome, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Rome. Enjoy a relaxing evening as you savor delicious local cuisine and reflect on the day's adventures.

Enjoy a delicious meal at La Bottega Roma, a top-rated dining destination in Rome. If you're in the mood to try something new, consider Pasta In Corso, another top spot with a mouthwatering menu. You might also want to secure a reservation at Trattoria Vecchia Roma. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Rome this evening.

Cap off your dinner by heading to La Botticella Of Poggi Giovanni, ideal for a leisurely evening with a drink in hand. Almalu Trastevere is another bar that offers an enjoyable setting. Similarly, Bar Viminale Di Pepi Maurilio is also a popular place to go on a night out, perfect for relaxing and socializing.

Take some time to reflect on your day and savor another beautiful night in Italy.

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Day 9

Day 9

  • Rome
  • Genoa
  • More

Drive 511 km, 5 hours 45 min

  • St Peter's Basilica
  • Piazza di Spagna
  • Spanish Steps
  • More

Embark on another extraordinary experience on day 9 of your road trip in Italy. Today, you will make 2 stops and experience some of the highlights of Vatican City and Rome. At the end of the day, you will enjoy the comforts of a top-rated hotel in Genoa, which will be your home away from home for 1 night.

A blend of family-friendly attractions, romantic experiences, and scenic views await you in Rome on today’s itinerary. First up is the wondrous major basilica, St. Peter's Basilica. Afterward, continue to Piazza Di Spagna, a public square every traveler should visit.

As you explore Rome’s charming streets, take in the lively atmosphere and get to know the character of the city. Next, make your way to Spanish Steps. This astonishing public square is an essential stop.

After soaking up all the sights of today's itinerary, you'll be ready to head in the direction of your accommodation in Genoa. Genoa offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Genoa. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Treat yourself to a delightful dinner at Vivarelli, highly recommended for tonight's dining. Or, if you're feeling adventurous, why not try Trattoria Ugo? It's another excellent option with a diverse menu. Consider reserving a table at TAZZE PAZZE Specialty Coffee as well. Known for its consistent customer satisfaction, it’s an ideal pick for tonight in Genoa.

Raise your glass to another unforgettable day in Italy!

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Day 10

Day 10

  • Genoa - Departure day
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  • Chiesa di San Giorgio
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Day 10 of your road trip in Italy is your departure day. This is your chance to catch a last glimpse of Genoa before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

If you're up for some more sightseeing, begin at Chiesa Di San Giorgio. This locally appreciated church is a popular place to see in the city.

On your last day in Italy, take time to indulge in shopping at Genoa’s popular marketplace, Via XX Settembre. Look for keepsakes or souvenirs to remind you of your trip.

Before you conclude your road trip in Italy, drop by another restaurant for a last chance at a memorable dining experience in Genoa.

Enjoy a lovely meal at Bar Festival, a top-rated place to have dinner tonight. Alternatively, if your taste buds call for something different, Il Marin is another top choice with a popular menu.

You’ll then say farewell to Genoa. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Italy!

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