10-Day Italy Self-Drive Road Trip With Itinerary from Genoa traveling east to La Spezia, Florence, San Gimignano, and Rome

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Escape the ordinary with this exciting 10-day road trip through Italy. Explore the diverse landscapes, lively cities, and beyond. Pack your bags, hit the road, and prepare for an unforgettable journey!

This perfectly planned road trip itinerary in Italy takes you through some of the best places to see in the country. You will spend 3 nights in Genoa, 1 night in La Spezia, 2 nights in Florence, 1 night in San Gimignano, and 2 nights in Rome. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Italy. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have got you covered.

Upon arriving in Genoa, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Italy on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Italy. Trevi Fountain and Pantheon are just a couple of the bucket-list attractions that await your discovery. Marvel at the remarkable Piazza Navona, learn more about the unique St. Peter's Basilica, and immerse yourself in the vibrant atmosphere of Vatican Museums.

As you hit the open road and drive through Genoa, Corniglia, Manarola, Riomaggiore, La Spezia, Pisa, Florence, Siena, San Gimignano, Rome, and Orvieto, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Italy. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Italy.

Throughout your road trip in Italy, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Italy.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodation, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in Italy fill up quickly, so book your spot early. Select a date and start planning your road trip in Italy today!

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Itinerary summary

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Days
Destination
Attractions
Overnight
Day
City & Overnight
Attractions
piazza De Ferrari
Lighthouse of GenoaGalata - Museo del mareVia GaribaldiPalazzo PodestàAquarium of Genoaporto antico
Cinque Terre National ParkManarola Overlook ViewpointPresepe di ManarolaRiomaggioreCastle of Riomaggiore
Knights' SquareMuseo dell'Opera del DuomoLeaning Tower of PisaBattistero di San GiovanniPiazza del Duomo, PisaPisa Cathedral
Basilica of Santa Croce in Florencepiazza della SignoriaPalazzo VecchioUffizi GalleryPonte VecchioThe Boboli Gardens
Siena Cathedralpiazza del CampoTower of MangiaChiesa di Sant'AgostinoTown Hall, Picture Gallery and Great TowerPiazza del Duomo, San Gimignano

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Day 1

Day 1

  • Genoa - Arrival day
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  • piazza De Ferrari
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Say hello to Genoa! Your exciting road trip through Italy is just about to start. Navigating the top places to see in the region is a breeze with a car. The rental vehicle of your choice will be ready for pickup upon your arrival in the city. You will stay in Genoa for 2 nights before you continue your adventure!

Genoa is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out Piazza De Ferrari, or just taking a stroll in the city center. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

As afternoon approaches, head to your chosen hotel in Genoa. Check-in typically starts around 2 to 4 PM at hotels in Italy. We recommend staying at a hotel in a central location for easy access to the best attractions, restaurants, and bars in the city.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Genoa, it's often a good idea to reserve a table in advance.

Dine in style at 7 Sensi cucina decontaminata, a top recommendation for dinner tonight. Or, for a change of pace, Alla Lunga Ristorante boasts a menu that's sure to impress. Also, be sure to check out Grand Hotel Savoia. Known as a local hotspot, it’s a great choice for tonight in Genoa.

After your meal, keep the night alive at a bar like Scurreria Beer & Bagel, known for its lively atmosphere. La Lepre is another top recommendation that provides the perfect setting with well-crafted drinks and a welcoming ambiance. Similarly, Bar Pisacane Iii offers an excellent atmosphere for those looking to amp up the evening.

Raise a toast to the start of your 10-day road trip in Italy!

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Day 2

Day 2

  • Genoa
  • More

Drive 13 km, 1 hour 13 min

  • Lighthouse of Genoa
  • Galata - Museo del mare
  • Via Garibaldi
  • Palazzo Podestà
  • Aquarium of Genoa
  • porto antico
  • More

Day 2 of your road trip across Italy promises a magnificent time exploring Genoa. You have 1 night left in Genoa. Take the opportunity to experience more of the best attractions and activities in the city.

Today’s agenda in Genoa includes a lighthouse, a maritime museum, a street, a palace, an aquarium, a public square and much more! Lighthouse Of Genoa is must-visit lighthouse and a great starting point for the day. Next, continue your journey to Galata Museo Del Mare (complex), a worthwhile maritime museum, located just a leisurely stroll away. Next, head to Via Garibaldi, a standout street, also available for your discovery today.

Each stop on today’s itinerary promises to leave you with lasting memories and a deeper appreciation for Genoa. If you’re looking for more, Palazzo Podestà is also an intriguing attraction that is worthwhile a visit. Lastly, don’t miss Aquarium Of Genoa, an impressive gem to see in the city.

Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.

As dinnertime approaches, it's time to head out for a bite to eat in Genoa. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.

Make sure to reserve a table at Zeffirino, an iconic dining spot in Genoa. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Trattoria Vegia Zena, a popular restaurant in Genoa. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of Trattoria delle Grazie, a hidden gem nestled in Genoa. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

Savor another day of unforgettable experiences in Italy!

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Day 3

Day 3

  • Genoa
  • La Spezia
  • More

Drive 132 km, 3 hours 22 min

  • Cinque Terre National Park
  • Manarola Overlook Viewpoint
  • Presepe di Manarola
  • Riomaggiore
  • Castle of Riomaggiore
  • More

On day 3 of your exciting self-drive vacation in Italy, you’ll soak in the magnificence of 3 destinations, Corniglia, Manarola, and Riomaggiore. When you’re not sightseeing, take time to relax at your selected hotel in La Spezia, where you’ll be staying for 1 night.

Start your day at Cinque Terre National Park. This UNESCO world heritage-listed national park is a captivating place to see in Genoa. Then, wander over to Manarola Overlook Viewpoint. If mesmerizing sites excite you, this observation deck will be right up your alley. Nearby, you’ll also find Presepe Di Manarola. This enchanting art installation is a favorite among visitors.

Genoa offers plenty to explore, ensuring every moment of your visit is filled with excitement and discovery. If you're up for more, Riomaggiore is an intriguing spot in the village that will captivate you with its unique charm. When you’re done at the sightseeing destination, don’t forget to check out the enchanting Castle Of Riomaggiore. Take a moment to appreciate the fascinating details of this frequently visited castle in Genoa.

When you’re done exploring for the day, you’ll drive to your hotel in La Spezia. Check in and spend some time relaxing before you head out to tour the city.

After a day of adventure, treat yourself to an exquisite dinner at one of La Spezia's best restaurants.

Treat yourself to a delicious dinner at The Colombaio Park, an excellent option for tonight's dining. With its reputation for pleasing customers, it’s a fantastic choice for tonight in La Spezia.

Raise your glass and celebrate another amazing day of your road trip in Italy!

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Day 4

Day 4

  • La Spezia
  • Florence
  • More

Drive 172 km, 2 hours 49 min

  • Knights' Square
  • Museo dell'Opera del Duomo
  • Leaning Tower of Pisa
  • Battistero di San Giovanni
  • Piazza del Duomo, Pisa
  • Pisa Cathedral
  • More

Experience an unparalleled adventure on day 4 of your road trip in Italy. This exciting part of your journey invites you to discover the renowned landmarks in 1 vibrant destinations - Pisa. After a day filled with exploration and new experiences, you will retreat to the hotel of your choice in Florence. You will spend 2 nights here for some well-deserved relaxation.

Bring your curiosity for today’s adventure around La Spezia. Some of the city’s most loved attractions await. Knights' Square is the perfect place to start. This public square is one of the most frequently visited places to visit in La Spezia. Next, head to Museo Dell'opera Del Duomo, an increasingly popular museum, known for its UNESCO world heritage-listed features.

In between the sights, don’t hesitate to take small detours to explore local stores and eateries. When you’re ready to continue your adventure, head to Leaning Tower Of Pisa. This UNESCO world heritage-listed monument offers a unique experience that is highly recommended. Meanwhile, Battistero Di San Giovanni adds its own distinct charm to your journey. Finish your day with a visit to Piazza Del Duomo, Pisa, a breathtaking public square in La Spezia.

After soaking up all the sights of today's itinerary, you'll be ready to head in the direction of your accommodation in Florence. Florence offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

Indulge in a memorable dining experience at one of Florence's most popular restaurants, and connect with friendly locals for an authentic adventure.

Enjoy a lovely meal at Ristorante Oliviero 1962, a top-rated place to have dinner tonight. Alternatively, if your taste buds call for something different, Di Poneta Novoli is another top choice with a popular menu. You could also check for a table at Caffe San Firenze. As an establishment that gains consistently high praises from customers, it’s an ideal choice in Florence tonight.

Keep the excitement of the evening going by visiting a bar or two. Manifattura is an excellent place to start. You could also check out Se·sto On Arno Rooftop Bar, offering a different kind of charm. A last recommendation for the day is Il Vinile. This bar promises an enjoyable experience with tasty drinks and a vibrant setting.

Relax and recharge in preparation for another adventurous day in Italy!

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Day 5

Day 5

  • Florence
  • More

Drive 10 km, 1 hour 3 min

  • Basilica of Santa Croce in Florence
  • piazza della Signoria
  • Palazzo Vecchio
  • Uffizi Gallery
  • Ponte Vecchio
  • The Boboli Gardens
  • More

Day 5 of your road trip will take you to the best attractions Florence has to offer. Cherish the 1 night you have left in Florence by discovering the best things there are to see and do in the city.

Today’s well-planned self-sightseeing route offers several fun adventures, photo-friendly spots, and historic treasures. Whether you decide to explore Florence on foot, use public transport, or join a guided tour, there are a few attractions you don’t want to miss. Basilica Of Santa Croce In Florence is the first of them. Spend some time admiring this culturally significant church before continuing your journey. Piazza Della Signoria is your next stop. This famous public square is one of the best-rated sights in Florence.

Consider grabbing some lunch or a light snack to keep your energy going. Beyond the above-mentioned attractions, today is also the perfect time to visit Palazzo Vecchio. This visually striking palace is a sight to behold. To round off your sightseeing experience, visit Uffizi Gallery and Ponte Vecchio.

Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.

Indulge in a memorable dining experience at one of Florence's most popular restaurants, and connect with friendly locals for an authentic adventure.

Enjoy a delicious meal at Ditta Artigianale, a highly-rated dining destination in Florence. If you're eager to try something different, consider Trattoria Da Burde, another top spot with a tantalizing menu. You might also want to secure a reservation at Casa Toscana. With a reputation for consistently satisfying customers, it’s an excellent choice to enhance your stay in Florence this evening.

Extend your evening after a delightful meal by visiting Bar 50 Rosso, which offers the perfect atmosphere for a night out. Moreover, Bitter Bar is another popular option for a drink or two. Likewise, Archea Brewery also provides a great ambiance for reminiscing about the day and raising a toast to your vacation.

As the day draws to a close, take a moment to unwind and prepare for the next exciting chapter of your road trip in in Italy.

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Day 6

Day 6

  • Florence
  • San Gimignano
  • More

Drive 122 km, 2 hours 19 min

  • Siena Cathedral
  • piazza del Campo
  • Tower of Mangia
  • Chiesa di Sant'Agostino
  • Town Hall, Picture Gallery and Great Tower
  • Piazza del Duomo, San Gimignano
  • More

Dive into day 6 of your remarkable road trip in Italy. Today you will explore Siena and San Gimignano, where you will have the opportunity to experience all the top things to see and do. At the end of the day, you’ll unwind at one of the finest accommodations in San Gimignano. You’ll stay here for 1 night.

Today, you'll explore some of the most beautiful places in Florence, including a church, a public square, a monument, a museum and much more! Start your day with a visit to Siena Cathedral. This notable church is a must-visit in the city. When you’re ready for your next discovery, continue to Piazza Del Campo, which may be one of the most romantic places you will experience today.

One of the best things about exploring Florence on a self-guided tour is that you set the pace. There’s plenty of time for detours and discovering hidden gems. When you’re ready for your next stop, make your way to Tower Of Mangia, a curiosity-inducing monument in the city. If you’re up for more discoveries, don’t forget to reserve some time for Chiesa Di Sant'agostino and Palazzo Comunale, Pinacoteca, Torre Grossa.

At the end of the day, you will drive to San Gimignano, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in San Gimignano. Enjoy a relaxing evening as you savor delicious local cuisine and reflect on the day's adventures.

Get a good night's sleep and look forward to another great day on the road in Italy!

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Day 7

Day 7

  • San Gimignano
  • Rome
  • More

Drive 273 km, 3 hours 51 min

  • Villa Borghese
  • Spanish Steps
  • Piazza di Spagna
  • Trevi Fountain
  • Altare della Patria
  • More

On day 7 of your road trip in Italy, you will get a true taste of the freedom a self-drive vacation in Europe entails. Today’s travel plans include stops at the most scenic, wondrous, and interesting places in Rome. In the evening, you’ll end up in Rome, where you will stay for 2 nights.

Prepare for a day full of fun adventures, romantic experiences, and natural wonders. When you’re ready, kick off your sightseeing adventure at Villa Borghese. This top-rated park is a must-visit for anyone seeking a unique vacation experience. Another sight you shouldn’t miss is Spanish Steps, one of the city’s most promising highlights.

Next, check out Piazza Di Spagna, one of the most timeless places to see in San Gimignano. This public square is a favorite among locals and travelers alike. Enjoy some downtime and refreshments before continuing to your next stop, Trevi Fountain. Wander around and soak in the romantic atmosphere this monument offers. Finally, take the path to the well-known Altare Della Patria, the last of our attraction recommendations for today.

When you’re done exploring for the day, you’ll drive to your hotel in Rome. Check in and spend some time relaxing before you head out to tour the city.

As you explore more of Rome, you'll discover that its culinary landscape is as diverse as its attractions. Whether you're craving traditional dishes bursting with local flavors or innovative creations that push the boundaries of taste, you're sure to find a dining experience that satisfies your cravings.

Make sure to reserve a table at La Bottega Roma, an iconic dining spot in Rome. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Pasta In Corso, a popular restaurant in Rome. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of Trattoria Vecchia Roma, a hidden gem nestled in Rome. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

To truly maximize your evening out, consider visiting La Botticella Of Poggi Giovanni after dinner. This bar is known for offering some of the best drinks and vibes in the city. Alternatively, head to Almalu Trastevere, another bar with an inviting ambiance. Similarly, Bar Viminale Di Pepi Maurilio also offers a great atmosphere, ensuring a night filled with enjoyment and relaxation.

Take some time to reflect on your day and savor another beautiful night in Italy.

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Day 8

Day 8

  • Rome
  • More

Drive 8 km, 59 min

  • Vatican Museums
  • Sistine Chapel
  • St Peter's Basilica
  • Pantheon
  • Piazza Navona
  • Trastevere
  • More

At the end of the day, you'll drive back to Rome, where you'll stay for 1 night more.

A top thing to do today is to explore Trastevere, a must-see neighborhood in Vatican City. It's the perfect starting point for exploring the top attractions in the area.

Bring your curiosity for today’s adventure around Rome. Some of the city’s most loved attractions await. Vatican Museums is the perfect place to start. This art museum is one of the most timeless places to visit in Rome.

Meanwhile, Pantheon adds its own distinct charm to your journey. Finish your day with a visit to Piazza Navona, a visually striking public square in Rome.

When you’re done exploring for the day, you’ll return to Rome and your accommodation.

As dinnertime approaches, it's time to head out for a bite to eat in Rome. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.

Make sure to reserve a table at RomAntica, an iconic dining spot in Rome. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Coso Ristorante, a popular restaurant in Rome. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of DEROMA - Farine Romane, a hidden gem nestled in Rome. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

Keep the evening going at Sant' Eustachio Caffè, a great choice for enjoying the after-dinner hours with a drink. You could also go to Yellowsquare Rome, which offers a similarly pleasant setting and great drinks. Another option is Caffè Portofino, which provides an inviting environment for unwinding after a busy day out.

Take some time to reflect on your day and savor another beautiful night in Italy.

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Day 9

Day 9

  • Rome
  • Genoa
  • More

Drive 519 km, 6 hours 15 min

  • Well of St Patrick
  • Orvieto Cathedral
  • Orvieto subterranea
  • Torre del Moro Orvieto
  • Pozzo della Cava
  • More

Embark on another extraordinary experience on day 9 of your road trip in Italy. Today, you will make 1 stop and experience some of the highlights of Orvieto. At the end of the day, you will enjoy the comforts of a top-rated hotel in Genoa, which will be your home away from home for 1 night.

Rome is brimming with adventures. Today’s wonderful stops include a monument, a church, a cave system, a cave and much more! Begin your sightseeing adventure at the captivating Well Of St. Patrick. Just a short distance away is Orvieto Cathedral, an enchanting church that draws visitors from far and near.

Continue your journey to Orvieto Underground, one of the village’s most up-and-coming spots that you shouldn’t miss. Another great site to visit is the often recommended Torre Del Moro Orvieto. Last up on today’s itinerary is a cave. Make your way to Pozzo Della Cava for some final sightseeing. Each attraction will leave you with lasting memories and a deeper appreciation for the rich heritage of Rome.

After soaking up all the sights of today's itinerary, you'll be ready to head in the direction of your accommodation in Genoa. Genoa offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Genoa. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Enjoy a lovely dining experience at Osteria Sant'Ilario, a popular restaurant in Genoa. This acclaimed establishment has earned the admiration of countless food lovers in the city. Alternatively, experience a taste of Genoa at La Cialtroneria, another great place to eat. With a menu designed to impress, it promises a journey of flavors that will leave you captivated. A third option to check out is the top-rated Manhattan Bar. It’s yet another ideal choice to enhance your time in Genoa tonight.

Celebrate another amazing day of your road trip adventure in Italy!

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Day 10

Day 10

  • Genoa - Departure day
  • More
  • Chiesa di San Giorgio
  • More

Day 10 of your road trip in Italy is your departure day. This is your chance to catch a last glimpse of Genoa before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

If you're up for some more sightseeing, begin at Chiesa Di San Giorgio. This often recommended church is a popular place to see in the city.

On your last day in Italy, take time to indulge in shopping at Genoa’s popular marketplace, Via Garibaldi. Look for keepsakes or souvenirs to remind you of your trip. Browse boutiques to find unique and stylish fashion pieces.

Before you conclude your road trip in Italy, drop by another restaurant for a last chance at a memorable dining experience in Genoa.

If you're in the mood to try something new, consider Trattoria Ugo, another top spot with a mouthwatering menu.

You’ll then say farewell to Genoa. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Italy!

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