10-Day Italy Self-Drive Road Trip With Itinerary from Genoa traveling east to Florence, Siena, and Rome

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Photo of Sand beach in Camogli by Genoa, Italy.
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Experience the freedom of the open road on an unforgettable 10-day road trip in Italy! Embark on a self-drive tour that caters to every traveler, featuring destinations like Genoa, Riomaggiore, Manarola, Corniglia, Pisa, Florence, Siena, San Gimignano, Montalcino, and Rome.

This perfectly planned road trip itinerary takes you through some of the best places to see in Italy. You will spend 4 nights in Genoa, 2 nights in Florence, 2 nights in Siena, and 1 night in Rome. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Italy. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have you covered.

Upon arriving in Genoa, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Italy on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Italy. Trevi Fountain and Colosseum are just a couple of the bucket-list attractions that await your discovery. Marvel at the remarkable Pantheon, learn more about the unique Piazza Navona, and immerse yourself in the vibrant atmosphere of St. Peter's Basilica.

As you hit the open road and drive through Genoa, Riomaggiore, Manarola, Corniglia, Pisa, Florence, Siena, San Gimignano, Montalcino, and Rome, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Italy. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Italy.

Throughout your road trip in Italy, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Italy.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodations, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in Italy fill up quickly, so book your spot early. Select a date and start planning your road trip in Italy today!

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Driver’s age is 30 - 65
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Pick-up: 10:00
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Day 1

Day 1

  • Genoa - Arrival day
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  • piazza De Ferrari
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Say hello to Genoa! Your exciting road trip through Italy is just about to start. Navigating the top places to see in the region is a breeze with a car. The rental vehicle of your choice will be ready for pickup upon your arrival in the city. You will stay in Genoa for 3 nights before you continue your adventure!

Genoa is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out Piazza De Ferrari, or just taking a stroll in the city center. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

Find your way to your hotel in Genoa. We recommend choosing a hotel in a central location for easy exploring. Check-in typically starts between 2 and 4 PM at hotels in Italy. Settle in and make plans for the evening.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Genoa, it's often a good idea to reserve a table in advance.

Enjoy a lovely meal at 7 Sensi cucina decontaminata, a top-rated place to have dinner tonight. Alternatively, if your taste buds call for something different, Alla Lunga Ristorante is another top choice with a popular menu. You could also check for a table at Grand Hotel Savoia. As an establishment that consistently gains high praises from customers, it’s an ideal choice in Genoa tonight.

Let the evening flow smoothly from dinner to drinks at Scurreria Beer & Bagel, a top-rated bar in the area. For other recommendations, La Lepre provides a perfect setting for rounding out your night with style and great drinks. Likewise, Bar Pisacane Iii offers a memorable night with diverse drink options and excellent service.

Raise a toast to the start of your 10-day road trip in Italy!

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Day 2

Day 2

  • Genoa
  • More

Drive 15 km, 1 hour 20 min

  • Lighthouse of Genoa
  • Galata - Museo del mare
  • Aquarium of Genoa
  • porto antico
  • Via Garibaldi
  • Piazza della Vittoria
  • More

Day 2 of your road trip will take you to the best attractions Genoa has to offer. Cherish the 2 nights you have left in the city and use the provided itinerary to discover what to see in Genoa.

Lighthouse Of Genoa is an ideal stop early in the day. This increasingly popular lighthouse is a must-visit in the city. When you’re ready for your next discovery, continue to Galata Museo Del Mare (complex), which may be one of the most instagrammable places you will experience today.

One of the best things about exploring Genoa on a self-guided tour is that you set the pace. There’s plenty of time for detours and discovering hidden gems. When you’re ready for your next stop, make your way to Aquarium Of Genoa, a top-rated aquarium in the city. If you’re up for more discoveries, don’t forget to reserve some time for Porto Antico and Via Garibaldi. End your day with a visit to Piazza Della Vittoria, a worthwhile public square that’s sure to leave a lasting impression.

Don’t forget to check out all the popular tours and experiences you can add to your travel plans in Italy. You can explore and select activities under each day of your itinerary.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Genoa, it's often a good idea to reserve a table in advance.

Enjoy a delicious meal at Zeffirino, a top-rated dining destination in Genoa. If you're in the mood to try something new, consider Trattoria Vegia Zena, another top spot with a mouthwatering menu. You might also want to secure a reservation at Trattoria delle Grazie. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Genoa this evening.

As the sun sets, rest up and recharge for the next leg of your road trip in Italy.

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Day 3

Day 3

  • Genoa
  • More

Drive 240 km, 4 hours 21 min

  • Riomaggiore
  • Manarola Overlook Viewpoint
  • Cinque Terre National Park
  • More

On day 3 of your road trip, you’ll start and end your day in Genoa, where you still have 1 night left. You'll spend part of the day exploring places of interest outside the immediate city, including Riomaggiore, Manarola, and Corniglia.

Riomaggiore makes a great addition to your morning plans. Continue your discovery at Manarola Overlook Viewpoint, a romantic observation deck with stories to tell.

As you stroll around Genoa, take in the distinct atmosphere and learn what makes this village so unique. Maximize your sightseeing with a visit to Cinque Terre National Park. This well-known national park offers a romantic encounter with Genoa. Whether you decide to get entrance tickets for all attractions or you prefer admiring from a distance, amazing experiences await on this day in Genoa.

When you’re done exploring the area’s best attractions, you’ll drive back to your accommodation in Genoa.

Indulge in a memorable dining experience at one of Genoa's most popular restaurants, and connect with friendly locals for a true cultural experience.

Enjoy a delicious meal at Osteria Sant'Ilario, a top-rated dining destination in Genoa. If you're in the mood to try something new, consider La Cialtroneria, another top spot with a mouthwatering menu. You might also want to secure a reservation at Manhattan Bar. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Genoa this evening.

Raise your glass to another unforgettable day in Italy!

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Day 4

Day 4

  • Genoa
  • Florence
  • More

Drive 263 km, 3 hours 47 min

  • Knights' Square
  • Leaning Tower of Pisa
  • Pisa Cathedral
  • Piazza del Duomo, Pisa
  • Battistero di San Giovanni
  • Campo santo
  • More

Experience an unparalleled adventure on day 4 of your road trip in Italy. This exciting part of your journey invites you to discover the renowned landmarks in 1 place, which are Pisa. At the end of the day, you will retreat to the hotel of your choice in Florence, where will spend 2 nights.

To truly experience Genoa, make sure to drop by Knights' Square. This locally appreciated public square is a must-visit for anyone seeking a unique vacation experience. Another sight you shouldn’t miss is Leaning Tower Of Pisa, one of the city’s best highlights.

Next, check out Pisa Cathedral, one of the most increasingly popular places to see in Genoa. This church is a favorite among locals and travelers alike. Enjoy some downtime and refreshments before continuing to your next stop, Piazza Del Duomo, Pisa. Wander around and soak in the culturally significant atmosphere this public square offers. Then, head to Battistero Di San Giovanni, a top-rated church that adds another dimension to your day. Finally, visit the beloved Campo Santo, the last of our attraction recommendations for today.

After soaking up all the sights on today's itinerary, you'll be ready to head to your accommodation in Florence. Florence offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Florence. Enjoy a relaxing evening as you savor delicious local cuisine.

Dine in style at Ristorante Oliviero 1962, a top recommendation for dinner tonight. Or, for a change of pace, Di Poneta Novoli boasts a menu that's sure to impress. Also, be sure to check out Caffe San Firenze. Known as a local hotspot, it’s a great choice for tonight in Florence.

Keep the excitement of the evening going by visiting a bar or two. Manifattura is an excellent place to start. You could also check out Se·sto On Arno Rooftop Bar, offering a different kind of charm. A last recommendation for the day is Il Vinile. This bar promises an enjoyable experience with tasty drinks and a vibrant setting.

Relax and look forward to more memorable moments to come!

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Day 5

Day 5

  • Florence
  • More

Drive 8 km, 1 hour 3 min

  • Cathedral of Santa Maria del Fiore
  • Palazzo Vecchio
  • Ponte Vecchio
  • Uffizi Gallery
  • Basilica of Santa Croce in Florence
  • piazzale Michelangelo
  • More

On day 5 of your road trip, you will have an entire day to discover what to see in Florence. You’ll stay in Florence for 1 night.

To truly experience Florence, make sure to drop by Cathedral Of Santa Maria Del Fiore. This spectacular church is a must-visit for anyone seeking a unique vacation experience. Another sight you shouldn’t miss is Palazzo Vecchio, one of the city’s best highlights.

Next, check out Ponte Vecchio, one of the most world-famous places to see in Florence. This historical landmark is a favorite among locals and travelers alike. Enjoy some downtime and refreshments before continuing to your next stop, Uffizi Gallery. Wander around and soak in the romantic atmosphere this art gallery offers. Then, head to Basilica Of Santa Croce In Florence, a top-rated church that adds another dimension to your day. Finally, visit the extraordinary Piazzale Michelangelo, the last of our attraction recommendations for today.

Don’t forget to check out all the popular tours and experiences you can add to your travel plans in Italy. You can explore and select activities under each day of your itinerary.

After a day of adventure, treat yourself to an exquisite dinner at one of Florence's best restaurants.

Enjoy a lovely meal at Ditta Artigianale, a top-rated place to have dinner tonight. Alternatively, if your taste buds call for something different, Trattoria Da Burde is another top choice with a popular menu. You could also check for a table at Casa Toscana. As an establishment that consistently gains high praises from customers, it’s an ideal choice in Florence tonight.

To truly maximize your evening out, consider visiting Bar 50 Rosso after dinner. This bar is known for offering some of the best drinks and vibes in the city. Alternatively, head to Bitter Bar, another bar with an inviting ambiance. Similarly, Archea Brewery also offers a great atmosphere, ensuring a night filled with enjoyment and relaxation.

Say good night to Florence and look forward to another great day of your road trip in Italy!

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Day 6

Day 6

  • Florence
  • Siena
  • More

Drive 159 km, 3 hours 8 min

  • Fortezza Medicea
  • Tower of Mangia
  • piazza del Campo
  • Facciatone
  • Siena Cathedral
  • Piazza del Duomo, San Gimignano
  • More

Dive into day 6 of your remarkable road trip in Italy. Today you'll explore 2 destinations, including Siena and San Gimignano. At the end of the day, you’ll unwind at one of the finest accommodations in Siena, where you'll spend 2 nights.

Check out the beloved monument, Fortezza Medicea (siena). Afterward, continue to Tower Of Mangia, a monument every traveler should visit. As you explore Florence’s charming streets, take in the lively atmosphere and get to know the character of the city.

Next, make your way to Piazza Del Campo. This extraordinary public square is an essential stop. Following that, head to Facciatone, another must-visit site that will enhance your experience. Don’t forget to stop by Siena Cathedral, a well-known church in the city. Finally, end your day with a visit to Piazza Del Duomo, a culturally significant public square that offers the perfect conclusion to your sightseeing of the day.

At the end of the day, you will drive to Siena, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Siena, it's often a good idea to reserve a table in advance.

Treat yourself to a wonderful meal at Enoteca I Terzi, a top-rated dining spot in Siena. If you're in the mood for something new, try Ristorante Tar-Tufo, another premier location with a delectable menu. You might also want to book a table at Antica Trattoria Papei. Known for its consistently satisfied patrons, it’s a perfect choice to elevate your evening in Siena.

After enjoying a delightful dinner, why not delve into the vibrant local bar scene? You might want to spend the evening at Meet Life Cafè, a well-loved spot among locals and tourists. Or, head to Maudit Pub. This bar boasts a welcoming environment that is perfect for winding down. You could also continue your night at Bar Impero Siena, another top-rated place in the area.

Celebrate another amazing day of your road trip adventure in Italy!

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Day 7

Day 7

  • Siena
  • More

Drive 84 km, 1 hour 54 min

  • Fortress of Montalcino
  • Piazza del Popolo
  • Church of Our Lady of Soccour
  • More

On day 7 of your road trip in Italy, you’ll start and end your day in Siena, but spend the day exploring what’s beyond the city. Since you still have 1 night to spend in Siena, there’s no need to rush. Experience Montalcino to the fullest today with this curated day itinerary.

Check out the worthwhile castle, Fortress Of Montalcino. Afterward, continue to Piazza Del Popolo, a public square every traveler should visit. As you explore Siena’s charming streets, take in the lively atmosphere and get to know the character of the village.

Next, make your way to Church Of Our Lady Of Soccour. This increasingly popular church is an essential stop.

When you’re done exploring for the day, you’ll return to Siena and your accommodation.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Siena, it's often a good idea to reserve a table in advance.

Enjoy a lovely meal at Osteria Quattro Venti, a top-rated place to have dinner tonight. Alternatively, if your taste buds call for something different, Fischi per Fiaschi is another top choice with a popular menu. You could also check for a table at Osteria da Divo. As an establishment that consistently gains high praises from customers, it’s an ideal choice in Siena tonight.

Cap off your dinner by heading to Charlie Mixology Bar Di Aldinucci Riccardo, ideal for a leisurely evening with a drink in hand. Bar Pinacoteca is another bar that offers an enjoyable setting. Similarly, San Paolo Pub is also a popular place to go on a night out, perfect for relaxing and socializing.

As the day draws to a close, take a moment to unwind and prepare for the next exciting chapter of your road trip in Italy.

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Day 8

Day 8

  • Siena
  • Rome
  • More

Drive 242 km, 3 hours 37 min

  • Colosseum
  • Roman Forum
  • Trevi Fountain
  • Pantheon
  • Piazza Navona
  • More

On day 8 of your road trip in Italy, your travel plans include 1 stop at the most scenic, wondrous, and interesting places in the region. Rome are on today's agenda. In the evening, you’ll end up in Rome, where you will stay for 1 night.

Colosseum makes a great addition to your morning plans. This world-famous archeological site is a breathtaking place to see in Siena. Continue your discovery at Roman Forum, a picture-perfect archeological site with stories to tell.

As you stroll around Siena, take in the distinct atmosphere and learn what makes this city so unique. Maximize your sightseeing with a visit to Trevi Fountain. This world-famous monument offers a romantic encounter with Siena. Next, make your way to Pantheon to add another highlight to your day. After that, visit Piazza Navona, a world-famous public square that’s sure to impress. Whether you decide to get entrance tickets for all attractions or you prefer admiring from a distance, amazing experiences await on this day in Siena.

When you’re done exploring for the day, you’ll drive to your hotel in Rome. Check in and relax before you head out to tour the city.

After a day of adventure, treat yourself to an exquisite dinner at one of Rome's best restaurants.

Make sure to reserve a table at La Bottega Roma, an iconic dining spot in Rome. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Pasta In Corso, a popular restaurant in Rome. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of Trattoria Vecchia Roma, a hidden gem nestled in Rome. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

Cap off your culinary experience with a visit to some of the most celebrated bars in the area. For instance, La Botticella Of Poggi Giovanni stands out as an excellent choice for a post-dinner cocktail. Alternatively, Almalu Trastevere offers an ideal atmosphere to enjoy the pleasures of the night. Bar Viminale Di Pepi Maurilio is also a great option that provides a perfect setting for a relaxing evening.

Relax and recharge in preparation for another adventurous day in Italy!

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Day 9

Day 9

  • Rome
  • Genoa
  • More

Drive 511 km, 5 hours 45 min

  • St Peter's Basilica
  • Piazza di Spagna
  • Spanish Steps
  • More

Your itinerary for day 9 of your road trip in Italy includes 2 stops and features some of the highlights of Vatican City and Rome. At the end of the day, enjoy the comforts of a top-rated hotel in Genoa, where you'll spend 1 night.

St. Peter's Basilica is must-visit major basilica and a great option for a daytime tour of the area. Continue your journey to Piazza Di Spagna, a world-famous public square, located just a leisurely stroll away. Next, head to Spanish Steps, a history-steeped public square, also available for your discovery today.

After soaking up all the sights on today's itinerary, you'll be ready to head to your accommodation in Genoa. Genoa offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Genoa. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Have a fantastic dining experience at Vivarelli, a highly recommended choice for tonight's dinner. If you're looking to mix things up, Trattoria Ugo offers an enticing alternative with its varied menu. Additionally, TAZZE PAZZE Specialty Coffee is worth considering. Renowned for satisfying diners, it’s an ideal option for tonight in Genoa.

Raise your glass and celebrate another amazing day of your road trip in Italy!

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Day 10

Day 10

  • Genoa - Departure day
  • More
  • Chiesa di San Giorgio
  • More

Day 10 of your road trip in Italy is your departure day. This is your chance to catch a last glimpse of Genoa before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

If you're up for some more sightseeing, begin at Chiesa Di San Giorgio. This beloved church is a hotspot among locals.

For a shopping spree in Genoa, we recommend the lively Via Garibaldi. Here, you'll find a range of shops you can browse for some souvenir shopping.

Before you conclude your road trip in Italy, drop by another restaurant for a last chance at a memorable dining experience in Genoa.

Dine in style at Bar Festival, a top recommendation for dinner tonight. Or, for a change of pace, Il Marin boasts a menu that's sure to impress.

You’ll then say farewell to Genoa. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Italy!

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Enjoy seamless planning
With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.
Explore with confidence
From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.
Secure your spot
Confirm your package instantly and lock in the best rate with secure payment and guaranteed availability.
Get instant confirmation
Shortly after booking, you’ll receive your full itinerary, including schedules, locations, and everything you need for a stress-free trip.
Personalize your itinerary
Each package includes a professionally crafted itinerary you can tailor to your travel style. A dedicated travel expert will make sure every detail fits your needs perfectly.
Easily make changes
Need to update plans? No problem. Whether before your trip or mid-journey, we’re just seconds away to help with quick adjustments.
Enjoy seamless planning
With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.
Explore with confidence
From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.

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