10-Day Italy Road Trip from Genoa traveling south to Florence, Rome, and Pisa

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Explore the best of Italy on a 10-day road trip! Uncover hidden gems and experience the rich culture firsthand as you journey through Genoa, Florence, Rome, Pisa, and Corniglia. This road trip itinerary in Italy seamlessly combines exploration with relaxation.

This perfectly planned road trip itinerary in Italy takes you through some of the best places to see in the country. You will spend 2 nights in Genoa, 2 nights in Florence, 4 nights in Rome, and 1 night in Pisa. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Italy. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have got you covered.

Upon arriving in Genoa, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Italy on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Italy. Trevi Fountain and Colosseum are just a couple of the bucket-list attractions that await your discovery.

As you hit the open road and drive through Genoa, Florence, Rome, Pisa, and Corniglia, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Italy. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Italy.

Throughout your road trip in Italy, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Italy.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodation, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in Italy fill up quickly, so book your spot early. Select a date and start planning your road trip in Italy today!

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Itinerary summary

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Days
Destination
Attractions
Overnight
Day
City & Overnight
Attractions
piazza De Ferrari
San Pietro in Banchi, GenoaAquarium of GenoaGalata - Museo del mare
piazzale MichelangeloUffizi GalleryPonte Vecchiopiazza della SignoriaCathedral of Santa Maria del Fiore
Sistine ChapelSt Peter's BasilicaSaint Peter's SquareVatican Museums
Orange GardenCircus MaximusCampo de' FioriCastel Sant'AngeloBelvedere del Gianicolo
Trevi FountainPiazza di SpagnaSpanish Stepspiazza del PopoloVilla Borghese

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Day 1

Day 1

  • Genoa - Arrival day
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  • piazza De Ferrari
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Say hello to Genoa! Your exciting road trip through Italy is just about to start. Navigating the top places to see in the region is a breeze with a car. The rental vehicle of your choice will be ready for pickup upon your arrival in the city. You will stay in Genoa for 1 night before you continue your adventure!

Genoa is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out Piazza De Ferrari or taking a stroll in the city center. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

Make your way to your chosen hotel. Check-in typically starts between 2 and 4 PM in Genoa. Make yourself at home and enjoy some downtime before heading out again.

As dinnertime approaches, it's time to head out for a bite to eat in Genoa. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.

Have a fantastic dining experience at Trattoria Vegia Zena, a highly recommended choice for tonight's dinner. If you're looking to mix things up, Trattoria delle Grazie offers an enticing alternative with its varied menu. Additionally, Manhattan Bar is worth considering. Renowned for satisfying diners, it’s an ideal option for tonight in Genoa.

Continue your evening by exploring the vibrant nightlife scene at Scurreria Beer & Bagel, a prime destination for a thrilling night out. Also, don’t forget to check out La Lepre, a bar that offers unique local touches.

Raise a toast to the start of your 10-day road trip in Italy!

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Day 2

Day 2

  • Florence
  • Genoa
  • More

Drive 259 km, 3 hours 28 min

  • San Pietro in Banchi, Genoa
  • Aquarium of Genoa
  • Galata - Museo del mare
  • More

Experience an unparalleled adventure on day 2 of your road trip in Italy. This exciting part of your journey invites you to discover the renowned landmarks in 1 vibrant destinations - Genoa. After a day filled with exploration and new experiences, you will retreat to the hotel of your choice in Florence. You will spend 2 nights here for some well-deserved relaxation.

Make Chiesa Di San Pietro In Banchi one of your first sightseeing stops in Genoa. Rated an average of 4.6 out of 5 stars by 419 travelers, a visit to this local attraction makes for a great introduction to the area.

Aquarium Of Genoa is a worthwhile attraction you can visit next. This public aquarium is a valued place of interest in the area, with an average rating of 4.5 out of 5 stars from 62,259 reviews. Up to 1,200,000 travelers visit this site every year to make their time in Genoa special.

Today is also the perfect opportunity to drop by Galata Museo Del Mare (complex). This building complex has been rated an average of 4.5 out of 5 stars by 8,322 visitors.

When you’re done exploring for the day, you’ll drive to Florence, where you'll have a hotel waiting for you. Check in and spend some time relaxing before you head out to explore the city.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Florence. Enjoy a relaxing evening as you savor delicious local cuisine and reflect on the day's adventures.

Set out on a gastronomic journey in Florence by reserving a table at Enoteca Pinchiorri. Renowned for its 3-star Michelin recognition, this restaurant presents an outstanding menu of italian contemporary cuisine. For a different taste, head over to Santa Elisabetta, renowned for its delectable creative, and mediterranean dishes. This distinguished 2-star Michelin-recipient is a favorite among guests, making it a worthy addition to your holiday plans. Craving more culinary excitement? Explore Gucci Osteria da Massimo Bottura, a highly rated local gem known for its exquisite italian contemporary, and international menu. With a 1-star Michelin acclaim, it promises a dining experience you won't want to miss. With its reputation for pleasing customers, it’s a fantastic choice for tonight in Florence.

Following your dinner, dive into the local bar culture at Manifattura. Enjoy this evening's relaxed ambiance with delightful drinks. Alternatively, go to Se·sto On Arno Rooftop Bar, the perfect place for those looking to experience the best of the nightlife. Similarly, Archea Brewery provides excellent drinks and a great atmosphere, ensuring a memorable night out.

Raise your glass and celebrate another amazing day of your road trip in Italy!

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Day 3

Day 3

  • Florence
  • More

Drive 4 km, 1 hour 6 min

  • piazzale Michelangelo
  • Uffizi Gallery
  • Ponte Vecchio
  • piazza della Signoria
  • Cathedral of Santa Maria del Fiore
  • More

Day 3 offers a multitude of experiences. You will stay in Florence for 1 night more, offering you enough time to explore at a relaxed pace.

Kick off the day at Piazzale Michelangelo, a top pick for today’s sightseeing. This square is rated an average of 4.8 out of 5 stars in 77,744 reviews.

Today is also your chance to visit Uffizi Gallery. Uffizi Gallery is a national museum with an average rating of 4.7 out of 5 stars from 61,794 reviews. Attracting more than 2,011,219 yearly visitors, this place of interest is an attraction you don’t want to miss out on.

Ponte Vecchio is another top attraction we highly recommend you visit today. This deck arch bridge is rated an average of 4.7 out of 5 stars by 118,099 visitors.

Beyond the attractions mentioned above, you also have the opportunity to visit Piazza Della Signoria. This square is rated an average of 4.8 out of 5 stars by 66,956 visitors.

Lastly, don’t miss out on Cathedral Of Santa Maria Del Fiore, a famous church in Florence. This attraction is rated an average of 4.8 out of 5 stars by 76,359 travelers.

One of the most unique ways of discovering what else Florence has to offer is by going on a top-rated tour. Be sure to check out all the experiences Florence offers and add your favorites to your Italy travel package below.

As dinnertime approaches, it's time to head out for a bite to eat in Florence. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.

Treat yourself to a wonderful meal at Trattoria Da Burde, a top-rated dining spot in Florence. If you're in the mood for something new, try Ristorante Buca Mario, another premier location with a delectable menu. You might also want to book a table at Eataly Firenze. Known for its consistently satisfied patrons, it’s a perfect choice to elevate your evening in Florence.

As the sun sets on another day of adventure, rest up and recharge for the next leg of your road trip in Italy.

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Day 4

Day 4

  • Rome
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Drive 285 km, 3 hours 57 min

  • Sistine Chapel
  • St Peter's Basilica
  • Saint Peter's Square
  • Vatican Museums
  • More

On day 4 of your road trip in Italy, you will get a true taste of the freedom a self-drive vacation in Europe entails. Today’s travel plans include stops at the most scenic, wondrous, and interesting places in Vatican City. In the evening, you’ll end up in Rome, where you will stay for 4 nights.

After soaking in Florence’s unique atmosphere, jump into the car with a full heart and drive in the direction of your next destination: Vatican City, Vatican City. Expect your car journey to take a minimum of 3 hours 14 min. When you arrive in Vatican City, it's time to take a break from the road.

An excellent attraction to start your day with is Sistine Chapel. This chapel is rated an average of 4.7 out of 5 stars in 52,083 reviews.

Continue your journey at St. Peter's Basilica. This major basilica is rated 4.8 out of 5 stars by 131,043 travelers from near and far. Approximately 11,000,000 people come to this place of interest every year to enjoy a unique experience in Vatican City.

Vatican City is also the home of Saint Peter's Square. This square has an average rating of 4.8 out of 5 stars from 38,954 visitors.

You can continue your self-guided sightseeing tour at Vatican Museums. A total of 1,612,530 people explore this attraction every year. Rated 4.6 out of 5 stars by 133,310 visitors, a visit to this top sight is time well spent.

After soaking up all the sights of today's itinerary, you'll be ready to hit the road in the direction of your accommodation in Rome. Rome offers plenty of top-rated hotels and other places to stay on any travel budget. Take some time to relax before you head out to explore.

As dinnertime approaches, it's time to head out for a bite to eat in Rome. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.

Treat yourself to an extraordinary dining experience at La Pergola, a 3-star Michelin restaurant offering an incredible mediterranean, and contemporary menu. Alternatively, if your taste buds call for something different, Il Pagliaccio is one of the best restaurants for creative, and innovative cuisine in Rome. This 2-star Michelin-awardee earns consistently high praises from guests. We also recommend checking out the menu at Enoteca La Torre. As a top-rated establishment with 2 Michelin star, it is an ideal choice for mediterranean, and creative cuisine in the city.

Continue your lively evening at La Botticella Of Poggi Giovanni, a perfect place for winding down or revving up the night, depending on which mood you’re in. Sant' Eustachio Caffè is another excellent bar that offers a great selection of drinks to suit any mood. If you prefer to go somewhere else, Caffè Portofino ensures a night out tailored to your taste.

Savor another day of unforgettable experiences in Italy!

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Day 5

Day 5

  • Rome
  • More

Drive 13 km, 1 hour 13 min

  • Orange Garden
  • Circus Maximus
  • Campo de' Fiori
  • Castel Sant'Angelo
  • Belvedere del Gianicolo
  • More

Day 5 of your road trip across Italy promises a magnificent time exploring Rome. You have 3 nights left in Rome. Take the opportunity to experience more of the best attractions and activities in the city.

Seize the day by visiting some of the best attractions in the area, like Orange Garden. This extraordinary park has an average rating of 4.7 out of 5 stars from 17,939 visitors.

Next, make your way to Circus Maximus. This circus is rated an average of 4.4 out of 5 stars in 44,741 reviews.

While in Rome, we also recommend a visit to Campo De' Fiori. This square has been rated an average of 4.4 out of 5 stars in 51,133 reviews.

If you’re keen to explore even more, then consider a visit to Castel Sant'angelo. This attraction gets around 918,591 yearly visitors. With an average rating of 4.7 out of 5 stars by 72,431 travelers, this museum is a highly recommended stop on your sightseeing around Rome.

Make your way to Belvedere Del Gianicolo, perhaps the most famous point of interest in Rome. This attraction is rated an average of 4.6 out of 5 stars in 18,731 reviews.

Immerse yourself in the local scene through top-rated tours and activities. You can choose from a wide variety of easy to challenging tours and easily add them to your travel package below.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Rome. Enjoy a relaxing evening as you savor delicious local cuisine and reflect on the day's adventures.

Enjoy a lovely meal at DEROMA - Farine Romane, a top-rated place to have dinner tonight. Alternatively, if your taste buds call for something different, La Taverna Italiana is another top choice with a popular menu. You could also check for a table at Centro. As an establishment that gains consistently high praises from customers, it’s an ideal choice in Rome tonight.

After enjoying a delightful dinner, why not delve into the vibrant local bar scene? You might want to spend the evening at The Apartment Bar Roma, a well-loved spot among locals and tourists. Or, head to Hotel Hassler Roma. This bar boasts a welcoming environment that is perfect for winding down.

Take some time to reflect on your day and savor another beautiful night in Italy.

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Day 6

Day 6

  • Rome
  • More

Drive 8 km, 1 hour 2 min

  • Trevi Fountain
  • Piazza di Spagna
  • Spanish Steps
  • piazza del Popolo
  • Villa Borghese
  • More

On day 6 of your road trip, you will have an entire day to explore Rome. You’ll stay in Rome for 2 nights and discover all the best things to see and do in the area.

When you're ready to see some sights, Trevi Fountain is a great place to start. This sculpture is rated an average of 4.8 out of 5 stars by 343,494 visitors.

Another popular attraction you can visit today is Piazza Di Spagna. This square has an average rating of 4.7 out of 5 stars from 113,658 travelers.

We also recommend a stop at Spanish Steps. The monumental staircase has been rated an average of 4.5 out of 5 stars by 57,211 visitors.

If you're keen to explore more, consider visiting Piazza Del Popolo. This square is a popular attraction with an average rating of 4.6 out of 5 stars from 89,807 reviews.

Villa Borghese is another easily accessible place to visit on this day of your trip. Stop by this urban zone of rome, rated 4.6 out of 5 stars in 69,749 reviews, to discover more of what makes it unique.

To do something one-of-a-kind on this day of your trip, you can join a tour. You can discover all of the most fun and eye-opening experiences in your destination below and secure your spot here.

As you explore more of Rome, you'll discover that its culinary landscape is as diverse as its attractions. Whether you're craving traditional dishes bursting with local flavors or innovative creations that push the boundaries of taste, you're sure to find a dining experience that satisfies your cravings.

Have a fantastic dining experience at Ristorante Tema, a highly recommended choice for tonight's dinner. If you're looking to mix things up, Maccheroni offers an enticing alternative with its varied menu. Additionally, RoYaL Art Cafè Roma is worth considering. Renowned for satisfying diners, it’s an ideal option for tonight in Rome.

Relax and recharge in preparation for another adventurous day in Italy!

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Day 7

Day 7

  • Rome
  • More

Drive 5 km, 53 min

  • Basilica di Santa Maria Maggiore
  • Colosseum
  • Roman Forum
  • Capitoline Hill
  • Altare della Patria
  • More

Day 7 of your road trip will take you to the best attractions Rome has to offer. Cherish the 1 night you have left in Rome by discovering the best things there are to see and do in the city.

Drop by the renowned Basilica Di Santa Maria Maggiore. This popular major basilica has been rated an average of 4.8 out of 5 stars by 27,678 visitors.

Another unforgettable place to experience is Colosseum. Rated 4.7 out of 5 stars by 328,821 visitors, this roman amphitheatre deserves a spot on today's sightseeing itinerary.

We also recommend a visit to Roman Forum. This square has been rated an average of 4.7 out of 5 stars in 114,450 reviews.

Another favorite attraction in the area is Capitoline Hill. This hill and popular place of interest enjoys a rating of 4.7 out of 5 stars from 19,557 local and international travelers.

If you’re keen to explore even more, then consider a visit to Altare Della Patria. This architectural structure gets around 1,683,070 annual visitors. With an average rating of 4.8 out of 5 stars from 49,843 travelers, this architectural structure is an attraction many avid travelers highly recommend visiting while in Rome.

Don’t forget to check out all the popular tours and activities you can add to your travel plan. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Rome. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Enjoy a delicious meal at Harry's Bar, a top-rated dining destination in Rome. If you're in the mood to try something new, consider Ristorante Amedeo, another top spot with a mouthwatering menu. You might also want to secure a reservation at VinAllegro. With a reputation for consistently satisfied customers, it’s a perfect choice to enhance your stay in Rome this evening.

Celebrate another amazing day of your road trip adventure in Italy!

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Day 8

Day 8

  • Pisa
  • Rome
  • More

Drive 360 km, 4 hours 18 min

  • largo di Torre Argentina
  • Pantheon
  • Piazza Navona
  • Foro Italico
  • More

On day 8 of your exciting self-drive vacation in Italy, you’ll soak in the magnificence of 1 destination, Rome. When you’re not sightseeing, take time to relax at your selected hotel in Pisa, where you’ll be staying for 1 night.

Start your sightseeing with a visit to Largo Di Torre Argentina. This square is rated an average of 4.5 out of 5 stars from 30,433 visitors.

Pantheon is another popular attraction you could visit today. This roman temple has a rating of 4.8 out of 5 stars from 189,682 visitors. Pantheon attracts up to 30,000,000 visitors every year.

Piazza Navona is also highly recommended by travelers. This square has a rating of 4.7 out of 5 stars from 158,771 visitors.

Foro Italico is an attraction you won’t want to miss. This point of interest is rated an average of 4.6 out of 5 stars in 25,438 reviews.

At the end of the day, you will drive to Pisa, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

As you explore more of Pisa, you'll discover that its culinary landscape is as diverse as its attractions. Whether you're craving traditional dishes bursting with local flavors or innovative creations that push the boundaries of taste, you're sure to find a dining experience that satisfies your cravings.

Make sure to reserve a table at Ristorante Capodimonte Pisa, an iconic dining spot in Pisa. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Baribaldi Pisa, a popular restaurant in Pisa. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of Restaurant -Pizzeria Il Mio Capriccio, a hidden gem nestled in Pisa. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

After enjoying a fulfilling meal, continue your evening at Jeffer Cocktails & Friends, ideal for those looking to unwind with a drink in a comfortable setting. Alternatively, Le Parisien Wine Bar offers a welcoming atmosphere for easing into the nightlife. Similarly, Las Volta Cocktailbar provides an excellent environment for a relaxed and enjoyable evening.

Get a good night's sleep and look forward to another great day on the road in Italy!

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Day 9

Day 9

  • Genoa
  • Pisa
  • Corniglia
  • More

Drive 204 km, 3 hours 34 min

  • Knights' Square
  • Leaning Tower of Pisa
  • Piazza del Duomo, Pisa
  • Pisa Cathedral
  • Cinque Terre National Park
  • More

Dive into day 9 of your remarkable road trip in Italy. Today you will explore Pisa, and Corniglia, where you will have the opportunity to experience all the top things to see and do. At the end of the day, you’ll unwind at one of the finest accommodations in Genoa. You’ll stay here for 1 night.

Be one of the day’s first visitors at Knights' Square. This square is rated an average of 4.5 out of 5 stars by 9,051 visitors.

When you’re finished at Knights' Square, head to Leaning Tower Of Pisa. This one-of-a-kind bell tower is rated an average of 4.7 out of 5 stars in 116,882 reviews. Every year, approximately 3,200,000 travelers come here to experience the bell tower for themselves.

Beyond the above-mentioned attractions, you also have the opportunity to visit Piazza Del Duomo, Pisa. This square is rated an average of 4.7 out of 5 stars by 104,550 visitors.

If you’re keen to explore more, then consider a visit to Pisa Cathedral. This cathedral is a much-appreciated attraction with an average rating of 4.8 out of 5 stars from 8,361 visitors.

After soaking in Pisa’s unique atmosphere, jump into the car with a full heart and drive in the direction of your next destination: Corniglia. Expect your car journey to take a minimum of 1 hour 35 min. When you arrive in Corniglia, it's time to take a break from the road.

When you're ready to see some sights, Cinque Terre National Park is a great place to start. This park is rated an average of 4.7 out of 5 stars by 43,526 visitors.

When you’re done exploring for the day, you’ll drive to Genoa, where you'll have a hotel waiting for you. Check in and spend some time relaxing before you head out to explore the city.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Genoa. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Experience a harmony of flavors at San Giorgio in Genoa by securing a reservation in advance. Known for its 1-star Michelin status, San Giorgio offers a delightful variety of dishes highlighting its delicious modern, and ligurian menu. If you're seeking an alternative culinary experience, be sure to explore The Cook, a highly recommended restaurant known for its enticing modern cuisine. This popular 1-star Michelin-awarded venue consistently exceeds expectations, ensuring a memorable holiday experience. Ready for another culinary adventure? Indulge your senses at Il Marin, a highly acclaimed restaurant celebrated for its exceptional seafood, and contemporary menu.

Head back to your accommodation in Genoa and get some rest in preparation for another magical day of your road trip in Italy!

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Day 10

Day 10

  • Genoa - Departure day
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  • Via Garibaldi
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Day 10 of your road trip in Italy is your departure day. This is your chance to catch a last glimpse of Genoa before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

As your final day in Italy unfolds, enjoy a last-minute shopping spree in Genoa's best shopping area. Enjoy finding the perfect gift or keepsake to remind you of your wonderful trip to Italy.

Begin your sightseeing with a visit to Via Garibaldi. This sightseeing destination is rated an average of 4.6 out of 5 stars in 5,399 reviews.

Before you conclude your road trip in Italy, drop by another restaurant for a last chance at a memorable dining experience in Genoa.

If you're eager to try something different, consider Osteria di Vico Palla, another top spot with a tantalizing menu.

You’ll then say farewell to Genoa. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Italy!

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