10-Day Italy Road Trip from Perugia to Assisi, Siena & Rome

Your amazing road trip adventure in Italy begins when you reach the incredible city of Assisi. There, you'll have your choice of the best hotels and places to stay.

We also recommend the best 3-star hotels, like the Domus Pacis Assisi. This hotel has an average rating of 4.3 out of 5 stars by 958 guests.

If these hotels are not available during your trip to the city of Assisi, our system will automatically help you find the best hotel for your stay.

Assisi has many popular destinations you can explore.

Assisi also has several great bars that will fit all travel budgets. One of the best bars in the city of Assisi is Bibenda Assisi Wine Tasting & Gourmet Food, Olive Oil and Chocolate Tastings. This bar has an average rating of 4.9 out of 5 stars by 878 customers.

Enjoy toasting the start of your 10-day vacation in Italy!

On day 2 of your road trip, you’ll explore the area around the region of Province of Perugia. You’ll be able to visit amazing attractions, like the incredible Basilica of San Francesco d'Assisi, Basilica di Santa Maria degli Angeli, Piazza IV Novembre, and many more.

One of the best travel destinations in the region of Province of Perugia is Basilica of San Francesco d'Assisi. This incredible attraction is a papal basilica and has an average rating of 4.9 out of 5 stars by 32,721 visitors.

Basilica di Santa Maria degli Angeli is another popular attraction you'll visit in the region of Province of Perugia. This spectacular attraction has an average rating of 4.8 out of 5 stars by 32,721 visitors.

Another of the best travel destinations you can visit in the region of Province of Perugia is Piazza IV Novembre. This amazing attraction is a square and is rated an average of 4.6 out of 5 stars by 9,048 visitors.

When you’re done exploring for the day, you’ll drive to your accommodation in the city of Assisi.

Raise your glass and relax after another big day of your road trip adventure through Italy!

Day 3 of your road trip through Italy gives you the opportunity to experience two places in one day. You’ll be able to choose how much time you want to spend in each area, where you’ll have the chance to visit attractions like the unforgettable Basilica di Santa Chiara, Rocca Paolina, Etruscan Arch, and many more.

One of the best places to visit in the region of Province of Perugia is the amazing Basilica di Santa Chiara. This attraction is a minor basilica and is rated an average of 4.7 out of 5 stars by 9,542 visitors.

You could also do sightseeing at the incredible Rocca Paolina. This rocca has an average rating of 4.7 out of 5 stars by 6,991 visitors.

Another unforgettable travel destination in the region of Province of Perugia is the outstanding Etruscan Arch. This architectural element has an average rating of 4.7 out of 5 stars by 1,124 visitors.

At the end of the day, you will drive to the city of Siena, where will have access to the best hotels and places to stay.

One of the best hotel options in the city of Siena is the 3-star Hotel Chiusarelli. This hotel has an average rating of 4.4 out of 5 stars by 1,224 guests.

You can also stay at one of the best 4-star hotel. The hotel Executive Hotel is a luxurious place to stay in the city of Siena. This hotel is rated an average of 4.1 out of 5 stars by 1,241 guests.

If you’re looking for the best cheap hotel, we recommend staying at the 3-star Sangallo Park Hotel. This 3-star hotel has an average rating of 4.5 out of 5 stars by 705 guests.

After a long day of driving and exploring, we recommend you try La Taverna di San Giuseppe, one of the best restaurants in the city of Siena. This restaurant has an average rating of 4.7 out of 5 stars by 1,767 customers.

Locals also recommend Osteria degli Svitati as one of the best restaurants in the city of Siena. Osteria degli Svitati is rated an average of 4.7 out of 5 stars by 911 customers.

Another of the best restaurants in the city of Siena is Osteria Il Carroccio. This restaurant has been rated an average of 4.7 out of 5 stars by 895 customers.

After dinner, visit La Taverna di San Giuseppe, which is considered one of the best bars in the city of Siena. This bar is rated an average of 4.7 out of 5 stars by 1,767 customers.

You can also enjoy drinks at a popular bar like Ristorante Gallo Nero. This bar has an average rating of 4.4 out of 5 stars by 829 customers.

Alternatively, San Paolo Pub is one of the best bars that locals recommend in the city of Siena. This bar is rated an average of 4.3 out of 5 stars by 704 customers.

Raise your glass in celebration of your incredible road trip adventure through Italy!

On day 4 of your road trip, you’ll explore the area around the region of Tuscany. You’ll be able to visit amazing attractions, like the incredible Piazzale Michelangelo, Uffizi Gallery, Piazza del Duomo, and many more.

One of the best travel destinations in the region of Tuscany is Piazzale Michelangelo. This incredible attraction is a square and has an average rating of 4.8 out of 5 stars by 73,198 visitors.

Uffizi Gallery is another popular attraction you'll visit in the region of Tuscany. This spectacular attraction has an average rating of 4.7 out of 5 stars by 73,198 visitors.

Another of the best travel destinations you can visit in the region of Tuscany is Piazza del Duomo. This amazing attraction is a square and is rated an average of 4.7 out of 5 stars by 99,460 visitors.

When you’re done exploring for the day, you’ll drive to your accommodation in the city of Siena.

We recommend eating at one of the best restaurants in the city of Siena, like Antica Trattoria Papei. This restaurant has an average rating of 4.3 out of 5 stars by 3,761 customers.

Osteria da Divo is another of the best restaurant options in the city of Siena. This restaurant is rated an average of 4.4 out of 5 stars by 1,062 customers.

Locals enjoy Ristorante Gallo Nero, one of the most popular restaurants in the city of Siena. The restaurant has an average rating of 4.4 out of 5 stars by 829 customers.

After dinner, visit one of the best bars in the city of Siena, Torrefazione Fiorella. This bar is rated an average of 4.8 out of 5 stars by 370 customers.

You can also enjoy drinks at a popular bar that locals recommend, like BLANDIS - Wine & Cafè. This bar has an average rating of 4.7 out of 5 stars by 291 customers.

Sindie is another of the best bars in the city of Siena. This bar is rated an average of 4.7 out of 5 stars by 124 customers.

Raise your glass and relax after another big day of your road trip adventure through Italy!

On day 5 of your road trip, you’ll explore the area around the region of Tuscany. You’ll be able to visit amazing attractions, like the incredible Central Market, Piazza del Duomo, Piazza della Signoria, and many more.

One of the best travel destinations in the region of Tuscany is Central Market. This incredible attraction has an average rating of 4.4 out of 5 stars by 40,633 visitors.

Piazza del Duomo is another popular attraction you'll visit in the region of Tuscany. This spectacular attraction has an average rating of 4.8 out of 5 stars by 40,633 visitors.

Another of the best travel destinations you can visit in the region of Tuscany is Piazza della Signoria. This amazing attraction is a square and is rated an average of 4.8 out of 5 stars by 63,038 visitors.

When you’re done exploring for the day, you’ll drive to your accommodation in the city of Siena.

We recommend eating at one of the best restaurants in the city of Siena, like Ristorante Taverna Di Cecco. This restaurant has an average rating of 4.4 out of 5 stars by 822 customers.

Ristorante San Desiderio is another of the best restaurant options in the city of Siena. This restaurant is rated an average of 4.4 out of 5 stars by 657 customers.

Locals enjoy PARTICOLARE di Siena, one of the most popular restaurants in the city of Siena. The restaurant has an average rating of 4.6 out of 5 stars by 598 customers.

After dinner, visit one of the best bars in the city of Siena, Osteria Quattro Venti. This bar is rated an average of 4.6 out of 5 stars by 304 customers.

You can also enjoy drinks at a popular bar that locals recommend, like Maudit Pub. This bar has an average rating of 4.4 out of 5 stars by 224 customers.

Charlie Mixology Bar di Aldinucci Riccardo is another of the best bars in the city of Siena. This bar is rated an average of 4.3 out of 5 stars by 138 customers.

Raise your glass and relax after another big day of your road trip adventure through Italy!

Day 6 of your road trip through Italy gives you the opportunity to experience two places in one day. You’ll be able to choose how much time you want to spend in each area, where you’ll have the chance to visit attractions like the unforgettable Roman Forum, Castel Sant'Angelo, Trevi Fountain, and many more.

One of the best places to visit in the city of Rome is the amazing Roman Forum. This attraction is a square and is rated an average of 4.7 out of 5 stars by 111,431 visitors.

You could also do sightseeing at the incredible Castel Sant'Angelo. This museum has an average rating of 4.7 out of 5 stars by 66,971 visitors.

Another unforgettable travel destination in the city of Rome is the outstanding Trevi Fountain. This sculpture has an average rating of 4.8 out of 5 stars by 321,961 visitors.

At the end of the day, you will drive to the city of Rome, where will have access to the best hotels and places to stay.

One of the best hotel options in the city of Rome is the 3-star Ibis Roma Fiera. This hotel has an average rating of 3.8 out of 5 stars by 1,099 guests.

You can also stay at one of the best 4-star hotel. The hotel Residence Mallia Hotel is a luxurious place to stay in the city of Rome. This hotel is rated an average of 4.2 out of 5 stars by 619 guests.

After a long day of driving and exploring, we recommend you try Cantina e Cucina, one of the best restaurants in the city of Rome. This restaurant has an average rating of 4.6 out of 5 stars by 7,907 customers.

Locals also recommend Ai Tre Scalini as one of the best restaurants in the city of Rome. Ai Tre Scalini is rated an average of 4.4 out of 5 stars by 2,950 customers.

Another of the best restaurants in the city of Rome is 433. This restaurant has been rated an average of 4.4 out of 5 stars by 2,341 customers.

After dinner, visit D’Angelo Caffè & Gastronomia - Bar Bistro Caffetteria Napoletana a Roma, which is considered one of the best bars in the city of Rome. This bar is rated an average of 4.7 out of 5 stars by 1,054 customers.

You can also enjoy drinks at a popular bar like Cantina e Cucina. This bar has an average rating of 4.6 out of 5 stars by 7,907 customers.

Alternatively, Ai Tre Scalini is one of the best bars that locals recommend in the city of Rome. This bar is rated an average of 4.4 out of 5 stars by 2,950 customers.

Raise your glass in celebration of your incredible road trip adventure through Italy!

On day 7 of your road trip, you’ll explore the area around the city of Rome. You’ll be able to visit amazing attractions, like the incredible Piazza di Spagna, Piazza del Popolo, Villa Borghese, and many more.

One of the best travel destinations in the city of Rome is Piazza di Spagna. This incredible attraction is a square and has an average rating of 4.7 out of 5 stars by 105,496 visitors.

Piazza del Popolo is another popular attraction you'll visit in the city of Rome. This spectacular attraction has an average rating of 4.6 out of 5 stars by 105,496 visitors.

Another of the best travel destinations you can visit in the city of Rome is Villa Borghese. This amazing attraction is an urban zone of rome and is rated an average of 4.6 out of 5 stars by 65,760 visitors.

When you’re done exploring for the day, you’ll drive to your accommodation in the city of Rome.

We recommend eating at one of the best restaurants in the city of Rome, like Roma Sparita. This restaurant has an average rating of 4.4 out of 5 stars by 2,073 customers.

La Taverna Italiana is another of the best restaurant options in the city of Rome. This restaurant is rated an average of 4.5 out of 5 stars by 1,897 customers.

Locals enjoy Ristorante Amedeo, one of the most popular restaurants in the city of Rome. The restaurant has an average rating of 4.3 out of 5 stars by 1,798 customers.

After dinner, visit one of the best bars in the city of Rome, VinAllegro. This bar is rated an average of 4.3 out of 5 stars by 1,167 customers.

You can also enjoy drinks at a popular bar that locals recommend, like Ristorante Tema. This bar has an average rating of 4.4 out of 5 stars by 939 customers.

Bar Tornatora Rome is another of the best bars in the city of Rome. This bar is rated an average of 4.3 out of 5 stars by 952 customers.

Raise your glass and relax after another big day of your road trip adventure through Italy!

On day 8 of your road trip, you’ll explore the area around the city of Rome. You’ll be able to visit amazing attractions, like the incredible Spanish Steps, Basilica Papale di Santa Maria Maggiore, Giardino degli Aranci, and many more.

One of the best travel destinations in the city of Rome is Spanish Steps. This incredible attraction is a monumental staircase and has an average rating of 4.5 out of 5 stars by 52,704 visitors.

Basilica Papale di Santa Maria Maggiore is another popular attraction you'll visit in the city of Rome. This spectacular attraction has an average rating of 4.8 out of 5 stars by 52,704 visitors.

Another of the best travel destinations you can visit in the city of Rome is Giardino degli Aranci. This amazing attraction is a park and is rated an average of 4.7 out of 5 stars by 16,817 visitors.

When you’re done exploring for the day, you’ll drive to your accommodation in the city of Rome.

We recommend eating at one of the best restaurants in the city of Rome, like La Taverna dei Fori Imperiali. This restaurant has an average rating of 4.4 out of 5 stars by 1,637 customers.

Maccheroni is another of the best restaurant options in the city of Rome. This restaurant is rated an average of 4.3 out of 5 stars by 1,633 customers.

Locals enjoy Coso Ristorante, one of the most popular restaurants in the city of Rome. The restaurant has an average rating of 4.3 out of 5 stars by 1,275 customers.

After dinner, visit one of the best bars in the city of Rome, Tigelleria Romana - Bistrot & Cafè. This bar is rated an average of 4.3 out of 5 stars by 792 customers.

You can also enjoy drinks at a popular bar that locals recommend, like La Botticella of Poggi Giovanni. This bar has an average rating of 4.7 out of 5 stars by 655 customers.

La Licata is another of the best bars in the city of Rome. This bar is rated an average of 4.5 out of 5 stars by 2,067 customers.

Raise your glass and relax after another big day of your road trip adventure through Italy!

Day 9 of your road trip through Italy gives you the opportunity to experience two places in one day. You’ll be able to choose how much time you want to spend in each area, where you’ll have the chance to visit attractions like the unforgettable Campo de' Fiori, Largo di Torre Argentina, Altar of the Fatherland, and many more.

One of the best places to visit in the city of Rome is the amazing Campo de' Fiori. This attraction is a square and is rated an average of 4.4 out of 5 stars by 47,948 visitors.

You could also do sightseeing at the incredible Largo di Torre Argentina. This square has an average rating of 4.5 out of 5 stars by 28,995 visitors.

Another unforgettable travel destination in the city of Rome is the outstanding Altar of the Fatherland. This architectural structure has an average rating of 4.8 out of 5 stars by 44,037 visitors.

At the end of the day, you will drive to the city of Assisi, where will have access to the best hotels and places to stay.

One of the best hotel options in the city of Assisi is the 3-star Domus Pacis Assisi. This hotel has an average rating of 4.3 out of 5 stars by 958 guests.

Raise your glass in celebration of your incredible road trip adventure through Italy!

Day 10 of your road trip in Italy is your departure day. This is your chance to catch one last glimpse of Assisi before saying goodbye to this wonderful destination. When you have time to explore the area before you make your way home, we recommend visiting some of the following attractions.

Your accommodation will also be strategically located for some last-minute shopping in the city of Assisi before you conclude your short European break.

You’ll then say farewell to Italy and begin your journey home, now filled with memories of unforgettable experiences in Italy!