10-Day Italy Self-Drive Road Trip With Itinerary from Perugia to Santa Maria degli Angeli, Siena, Florence, and Lucca

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Escape the ordinary with this exciting 10-day road trip through Italy. Explore the diverse landscapes, lively cities, and beyond. Pack your bags, hit the road, and prepare for an unforgettable journey!

This perfectly planned road trip itinerary in Italy takes you through some of the best places to see in the country. You will spend 3 nights in Perugia, 1 night in Santa Maria degli Angeli, 1 night in Siena, 2 nights in Florence, and 2 nights in Lucca. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Italy. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have got you covered.

Upon arriving in Perugia, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Italy on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Italy. Ponte Vecchio and Leaning Tower Of Pisa are just a couple of the bucket-list attractions that await your discovery. Marvel at the remarkable Piazza Del Duomo, Pisa, learn more about the unique Piazzale Michelangelo, and immerse yourself in the vibrant atmosphere of Cathedral Of Santa Maria Del Fiore.

As you hit the open road and drive through Perugia, Santa Maria degli Angeli, Spello, Siena, Florence, Pisa, Lucca, Corniglia, Vernazza, Manarola, and Orvieto, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Italy. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Italy.

Throughout your road trip in Italy, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Italy.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodation, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in Italy fill up quickly, so book your spot early. Select a date and start planning your road trip in Italy today!

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Driver’s age is 30 - 65
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Days
Destination
Attractions
Overnight
Day
City & Overnight
Attractions
Frontone Gardens
The Fontana MaggiorePiazza IV NovembreNational GalleryCarducci GardensRocca PaolinaNational Archaeological Museum of Umbria
Basilica of San Francesco d'AssisiPortico of Monte FrumentarioPiazza del ComuneBasilica di Santa ChiaraRocca MaggiorePorta Consolare
Palazzo SalimbeniFortezza MediceaBasilica of San DomenicoSiena Cathedralpiazza del CampoTower of Mangia
Palazzo PittiPonte VecchioUffizi GalleryBasilica of Santa Croce in Florencepiazza della Signoria
Basilica of Santa Maria NovellaCentral MarketCathedral of Santa Maria del FioreGalleria dell'AccademiaDavidpiazzale Michelangelo

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Day 1

Day 1

  • Perugia - Arrival day
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  • Frontone Gardens
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Your road trip adventure in Italy begins as soon as you reach Perugia and pick up your car. You’ll stay in Perugia for 2 nights and explore the best things to see and do, sample the local cuisine, and choose from a curated selection of the best hotels and places to stay in the city.

Perugia is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out Frontone Gardens, or just taking a stroll in the city center. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

Find your way to your hotel in Perugia. We recommend choosing a hotel in a central location for easy exploring. Check-in typically starts between 2 and 4 PM at hotels in Italy. Settle in and make plans for the evening.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Perugia, it's often a good idea to reserve a table in advance.

Treat yourself to a delicious dinner at Ristorante Settimo Sigillo, an excellent option for tonight's dining. Looking for something different? Caffè Baglioni offers a tantalizing alternative with its diverse menu. And don’t miss Bar Pellas. With its reputation for pleasing customers, it’s a fantastic choice for tonight in Perugia.

To truly maximize your evening out, consider visiting Tommi Bar after dinner. This bar is known for offering some of the best drinks and vibes in the city. Alternatively, head to Valentina, another bar with an inviting ambiance. Similarly, Caffe Dal Perugino also offers a great atmosphere, ensuring a night filled with enjoyment and relaxation.

Raise a toast to the start of your 10-day road trip in Italy!

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Day 2

Day 2

  • Perugia
  • More

Drive 2 km, 29 min

  • The Fontana Maggiore
  • Piazza IV Novembre
  • National Gallery
  • Carducci Gardens
  • Rocca Paolina
  • National Archaeological Museum of Umbria
  • More

Day 2 of your road trip across Italy promises a magnificent time exploring Perugia. You have 1 night left in Perugia. Take the opportunity to experience more of the best attractions and activities in the city.

Prepare for a day full of fun adventures, breathtaking views, and photo-friendly spots. When you’re ready, kick off your sightseeing adventure at The Fontana Maggiore. This underrated monument is a must-visit for anyone seeking a unique vacation experience. Another sight you shouldn’t miss is Piazza Iv Novembre, one of the city’s best highlights.

Next, check out National Gallery, one of the most often recommended places to see in Perugia. This art gallery is a favorite among locals and travelers alike. Enjoy some downtime and refreshments before continuing to your next stop, Carducci Gardens. Wander around and soak in the awe-inspiring atmosphere this park offers. Then, head to Rocca Paolina, a top-rated historical landmark that adds another dimension to your day. Finally, visit the beloved National Archaeological Museum Of Umbria, the last of our attraction recommendations for today.

Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Perugia. Enjoy a relaxing evening as you savor delicious local cuisine and reflect on the day's adventures.

Savor the flavors at La Taverna, a top pick for dinner tonight. Alternatively, Ristorante del Sole beckons with its unique menu offerings. Also, consider Al Mangiar Bene. With its consistent customer satisfaction, it’s an excellent option for dining in Perugia tonight.

Cap off your dinner by heading to Caffè Fortebraccio, ideal for a leisurely evening with a drink in hand. Caffe Del Banco is another bar that offers an enjoyable setting. Similarly, Dempsey's Perugia is also a popular place to go on a night out, perfect for relaxing and socializing.

As the sun sets on another day of adventure, rest up and recharge for the next leg of your road trip in Italy.

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Day 3

Day 3

  • Perugia
  • Assisi
  • More

Drive 55 km, 1 hour 48 min

  • Basilica of San Francesco d'Assisi
  • Portico of Monte Frumentario
  • Piazza del Comune
  • Basilica di Santa Chiara
  • Rocca Maggiore
  • Porta Consolare
  • More

Dive into day 3 of your remarkable road trip in Italy. Today you will explore Santa Maria degli Angeli and Spello, where you will have the opportunity to experience all the top things to see and do. At the end of the day, you’ll unwind at one of the finest accommodations in Santa Maria degli Angeli. You’ll stay here for 1 night.

Get ready for a day filled with fun adventures, breathtaking views, and photo-friendly spots in the charming town of Perugia. Your adventure starts at Basilica Of San Francesco D'assisi, a notable local hot spot. Another notable attraction to explore is Portico Of Monte Frumentario. This locally appreciated historical landmark is known for its stunning appeal.

After soaking in the highlights of these sights, take some time to wander Perugia's streets and immerse yourself in the local atmosphere. When you're ready to continue your sightseeing adventure, head to Piazza Del Comune. This symbolic public square offers a fascinating experience that many visitors find memorable. Basilica Di Santa Chiara is also worth visiting, along with Rocca Maggiore. These standout landmarks offer unique experiences that add to the day’s enjoyment. End your day at Porta Consolare. This up-and-coming monument provides a fitting finale to your sightseeing.

After soaking up all the sights of today's itinerary, you'll be ready to head in the direction of your accommodation in Santa Maria degli Angeli. Santa Maria degli Angeli offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

After a day of adventure, treat yourself to an exquisite dinner at one of Santa Maria degli Angeli's best restaurants.

Continue your lively evening at Bibenda Assisi Wine Tasting & Gourmet Food, Olive Oil And Chocolate Tastings, a perfect place for winding down or revving up the night, depending on which mood you’re in.

Take some time to reflect on your day and savor another beautiful night in Italy.

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Day 4

Day 4

  • Assisi
  • Siena
  • More

Drive 132 km, 2 hours 19 min

  • Palazzo Salimbeni
  • Fortezza Medicea
  • Basilica of San Domenico
  • Siena Cathedral
  • piazza del Campo
  • Tower of Mangia
  • More

Embark on another extraordinary experience on day 4 of your road trip in Italy. Today, you will make 1 stop and experience some of the highlights of Siena. At the end of the day, you will enjoy the comforts of a top-rated hotel in Siena, which will be your home away from home for 1 night.

Santa Maria degli Angeli is brimming with adventures. Today’s wonderful stops include a palace, a monument, a church, a public square and much more! Begin your sightseeing adventure at the underrated Palazzo Salimbeni and allow yourself time to explore. Just a short distance away you'll find your next stop, Fortezza Medicea (siena), a picture-perfect monument that draws visitors from far and near.

Continue your journey to Basilica Of San Domenico, one of the city’s most curiosity-inducing spots that you shouldn’t miss. Another great site to visit is the interesting Siena Cathedral. When you're finished at the church, Piazza Del Campo awaits your visit. This public square is an UNESCO world heritage-designated highlight on today's itinerary. Last up is a monument - the often recommended Tower Of Mangia.

When you’re done exploring for the day, you’ll drive to your hotel in Siena. Check in and spend some time relaxing before you head out to tour the city.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Siena. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Make sure to reserve a table at Enoteca I Terzi, an iconic dining spot in Siena. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Ristorante Tar-Tufo, a popular restaurant in Siena. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of Antica Trattoria Papei, a hidden gem nestled in Siena. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

Keep the evening going at Meet Life Cafè, a great choice for enjoying the after-dinner hours with a drink. You could also go to Maudit Pub, which offers a similarly pleasant setting and great drinks. Another option is Bar Impero Siena, which provides an inviting environment for unwinding after a busy day out.

Say good night to Siena and look forward to another great day of your road trip in Italy!

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Day 5

Day 5

  • Siena
  • Florence
  • More

Drive 73 km, 1 hour 26 min

  • Palazzo Pitti
  • Ponte Vecchio
  • Uffizi Gallery
  • Basilica of Santa Croce in Florence
  • piazza della Signoria
  • More

On day 5 of your road trip in Italy, you will get a true taste of the freedom a self-drive vacation in Europe entails. Today’s travel plans include stops at the most scenic, wondrous, and interesting places in Florence. In the evening, you’ll end up in Florence, where you will stay for 2 nights.

Today’s itinerary in Siena covers several incredible sights, including a palace, a historical landmark, an art gallery, a church, a public square and much more! Start your adventure at Pitti Palace. This captivating palace is a place that is appreciated by travelers and locals alike. Next, immerse yourself in the visually striking wonders of Ponte Vecchio, a must-see historical landmark in the city.

Consider stopping for a small bite to eat or a drink at a local eatery to keep your energy going. When you’re ready, continue your discovery with a visit to Uffizi Gallery. This impressive art gallery offers an enriching experience. For a change of pace, head to Basilica Of Santa Croce In Florence, where you can take in culturally significant features. Conclude your self-guided sightseeing tour with a visit to Piazza Della Signoria. These sights offer a fulfilling end to a perfect day.

At the end of the day, you will drive to Florence, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Florence. Enjoy a relaxing evening as you savor delicious local cuisine and reflect on the day's adventures.

Treat yourself to a wonderful meal at Ristorante Oliviero 1962, a top-rated dining spot in Florence. If you're in the mood for something new, try Di Poneta Novoli, another premier location with a delectable menu. You might also want to book a table at Caffe San Firenze. Known for its consistently satisfied patrons, it’s a perfect choice to elevate your evening in Florence.

Following your dinner, dive into the local bar culture at Manifattura. Enjoy this evening's relaxed ambiance with delightful drinks. Alternatively, go to Se·sto On Arno Rooftop Bar, the perfect place for those looking to experience the best of the nightlife. Similarly, Il Vinile provides excellent drinks and a great atmosphere, ensuring a memorable night out.

Relax and reminisce about your day in Italy and look forward to more memorable moments to come!

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Day 6

Day 6

  • Florence
  • More

Drive 11 km, 1 hour 6 min

  • Basilica of Santa Maria Novella
  • Central Market
  • Cathedral of Santa Maria del Fiore
  • Galleria dell'Accademia
  • David
  • piazzale Michelangelo
  • More

Day 6 offers a multitude of experiences. You will stay in Florence for 1 night more, offering you enough time to explore at a relaxed pace.

Discover a day packed with family-friendly attractions, romantic experiences, and breathtaking views in Florence. Begin your sightseeing with Basilica Di Santa Maria Novella, Firenze (fi). This notable church is one of the top attractions in the city. Proceed to Central Market, another must-visit attraction.

As you wander through the inviting streets of Florence, soak in the lively ambiance and take the opportunity to snap some photos. Next, head to Cathedral Of Santa Maria Del Fiore. This widely recognized church is a traveler-favorite. Not far away, you’ll find Galleria Dell'accademia, another key site on your sightseeing itinerary. David is yet another highly recommended place to visit nearby, offering plenty to discover for curious travelers. Conclude your day at Piazzale Michelangelo and uncover why it's recognized as one of the city's most impressive attractions.

Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.

As you explore more of Florence, you'll discover that its culinary landscape is as diverse as its attractions. Whether you're craving traditional dishes bursting with local flavors or innovative creations that push the boundaries of taste, you're sure to find a dining experience that satisfies your cravings.

Treat yourself to a wonderful meal at Ditta Artigianale, a top-rated dining spot in Florence. If you're in the mood for something new, try Trattoria Da Burde, another premier location with a delectable menu. You might also want to book a table at Casa Toscana. Known for its consistently satisfied patrons, it’s a perfect choice to elevate your evening in Florence.

After your meal, keep the night alive at a bar like Bar 50 Rosso, known for its lively atmosphere. Bitter Bar is another top recommendation that provides the perfect setting with well-crafted drinks and a welcoming ambiance. Similarly, Archea Brewery offers an excellent atmosphere for those looking to amp up the evening.

Say good night to Florence and look forward to another great day of your road trip in Italy!

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Day 7

Day 7

  • Florence
  • Lucca
  • More

Drive 107 km, 2 hours 14 min

  • Pisa Cathedral
  • Piazza del Duomo, Pisa
  • Leaning Tower of Pisa
  • Walls of Lucca
  • St Martin Cathedral
  • Piazza dell'Anfiteatro
  • More

On day 7 of your exciting self-drive vacation in Italy, you’ll soak in the magnificence of 2 destinations, Pisa and Lucca. When you’re not sightseeing, take time to relax at your selected hotel in Lucca, where you’ll be staying for 2 nights.

Start by visiting Pisa Cathedral, a prime spot to begin your journey. This stunning church is sure to impress. Next on your list is Piazza Del Duomo, Pisa, another must-visit landmark and wondrous public square renowned for its stunning features.

While exploring and sightseeing, take time to savor the culture of Florence by sampling some local delicacies. When you’re ready for more sightseeing, head to Leaning Tower Of Pisa. This historic monument is an essential place to visit for anyone looking for the full Florence experience. We also recommend visiting Mura Di Lucca, an intriguing historical landmark. Nearby, you'll also find St Martin Cathedral, ready to add charm to your journey. End your self-guided sightseeing tour with a stop at Piazza Dell'anfiteatro and wrap up your day with its enchanting appeal.

After soaking up all the sights of today's itinerary, you'll be ready to head in the direction of your accommodation in Lucca. Lucca offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

As you explore more of Lucca, you'll discover that its culinary landscape is as diverse as its attractions. Whether you're craving traditional dishes bursting with local flavors or innovative creations that push the boundaries of taste, you're sure to find a dining experience that satisfies your cravings.

Make sure to reserve a table at Gli Orti di Via Elisa, an iconic dining spot in Lucca. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Bar Caffè Ristretto, a popular restaurant in Lucca. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of Ristorante Schiaffino, a hidden gem nestled in Lucca. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

After savoring a delicious meal, step into the vibrant nightlife at Lebowski - Cocktail Bar, where the evening is just getting started. In the same way, Blend offers a unique charm perfect for experiencing the local bar scene in Lucca. Franklin'33 is another top-recommended bar that is sure to get you into the mood for some dancing and celebrating.

Raise your glass to another unforgettable day in Italy!

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Day 8

Day 8

  • Lucca
  • More

Drive 219 km, 4 hours 10 min

  • Scalinata Lardarina
  • Chiesa Di San Pietro
  • Ruins of Doria Tower
  • Church of St. Margaret of Antioch
  • Cinque Terre National Park
  • Manarola Overlook Viewpoint
  • More

On day 8 of your road trip, you’ll start and end your day in Lucca, but spend part of the day exploring places of interest outside the immediate city. On today's itinerary, you'll find attractions in Corniglia, Vernazza, and Manarola. You still have 1 night left in Lucca.

Savor the day by visiting some of the best places to see in Lucca, including a hiking area, a church, a monument, a national park, an observation deck and much more! Start your adventure at Scalinata Lardarina. This intriguing hiking area is a must-visit for travelers looking for a unique holiday experience. Make your way to Chiesa Di San Pietro located in Lucca for another exciting encounter.

Next, immerse yourself in the setting of Ruins Of Doria Tower. Its visually striking features will captivate you. After the monument, continue your tour of the village with a visit to Church Of St. Margaret Of Antioch. Visitors usually appreciate the picture-perfect features of this church. Next up is Cinque Terre National Park, a highly recommended national park. For a change of pace, head to Manarola Overlook Viewpoint. As one of the most intriguing attractions in Lucca, this observation deck is the perfect place to end your self-guided sightseeing tour.

When you’re done exploring for the day, you’ll return to Lucca and your accommodation.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Lucca. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Make sure to reserve a table at Osteria Nova, an iconic dining spot in Lucca. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of La Bottega di Anna e Leo, a popular restaurant in Lucca. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of Ristorante Per 21, a hidden gem nestled in Lucca. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

After your meal, keep the night alive at a bar like La Tana Del Boia, known for its lively atmosphere. Vinarkia Della Pavona - Cocktail Bar is another top recommendation that provides the perfect setting with well-crafted drinks and a welcoming ambiance. Similarly, Magellano offers an excellent atmosphere for those looking to amp up the evening.

As the day draws to a close, take a moment to unwind and prepare for the next exciting chapter of your road trip in in Italy.

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Day 9

Day 9

  • Lucca
  • Perugia
  • More

Drive 317 km, 4 hours 20 min

  • Well of St Patrick
  • Orvieto Cathedral
  • Museo dell'Opera del Duomo
  • Orvieto subterranea
  • Torre del Moro Orvieto
  • Pozzo della Cava
  • More

Experience an unparalleled adventure on day 9 of your road trip in Italy. This exciting part of your journey invites you to discover the renowned landmarks in 1 vibrant destinations - Orvieto. After a day filled with exploration and new experiences, you will retreat to the hotel of your choice in Perugia. You will spend 1 night here for some well-deserved relaxation.

Lucca is home to plenty of attractions that offer fun adventures, scenic views, and photo-friendly spots! Start at Well Of St. Patrick, a popular monument that is worthwhile a visit in the village. Nearby, you’ll find Orvieto Cathedral, enchanting visitors with its visually striking appeal. Continue your exploration at Museo Dell'opera Del Duomo. This museum is one of the village’s most often recommended spots.

Enjoy the freedom of exploring Lucca at your own pace and find hidden gems along the way. If you want to see more picture-perfect spots, make sure to visit Orvieto Underground. After exploring the cave system, head to the locally appreciated Torre Del Moro Orvieto. Lastly, wrap up today’s self-guided sightseeing tour with a visit to Pozzo Della Cava, a place of heritage-rich interest in Lucca.

When you’re done exploring for the day, you’ll drive to your hotel in Perugia. Check in and spend some time relaxing before you head out to tour the city.

As dinnertime approaches, it's time to head out for a bite to eat in Perugia. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.

Enjoy a delicious meal at Perugia Plaza Hotel, a highly-rated dining destination in Perugia. If you're eager to try something different, consider Elfo Pub Perugia, another top spot with a tantalizing menu. You might also want to secure a reservation at Sangallo Palace Hotel. With a reputation for consistently satisfying customers, it’s an excellent choice to enhance your stay in Perugia this evening.

Cap off your culinary experience with a visit to some of the most celebrated bars in the area. For instance, Il Birrino stands out as an excellent choice for a post-dinner cocktail. Alternatively, Quei Bravi Ragazzi offers an ideal atmosphere to enjoy the pleasures of the night. Lo Chalet - Lounge Bar is also a great option that provides a perfect setting for a relaxing evening.

Get a good night's sleep and look forward to another great day on the road in Italy!

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Day 10

Day 10

  • Perugia - Departure day
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  • Etruscan Arch
  • More

Day 10 of your road trip in Italy is your departure day. This is your chance to catch a last glimpse of Perugia before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

If you're up for some more sightseeing, we recommend visiting Etruscan Arch, a culturally significant historical landmark before you head out.

Make the most of your final day in Italy by visiting Perugia’s iconic markets and shopping establishments. Secure the perfect souvenirs for your family and friends back home or buy yourself a remembrance of your amazing experience in Italy.

Before you conclude your road trip in Italy, drop by another restaurant for a last chance at a memorable dining experience in Perugia.

Treat yourself to a delightful dinner at Alphaville, highly recommended for tonight's dining. Or, if you're feeling adventurous, why not try Osteria a Priori? It's another excellent option with a diverse menu.

You’ll then say farewell to Perugia. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Italy!

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