10-Day Italy Self-Drive Road Trip With Itinerary from Perugia traveling south to Rome, Naples, Viterbo, and Pisa

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Explore the best of Italy on a 10-day road trip! Uncover hidden gems and experience the rich culture firsthand as you journey through Perugia, Pissignano, Rome, Naples, Ravello, Amalfi, Tivoli, Viterbo, Pisa, and Siena. This road trip itinerary in Italy seamlessly combines exploration with relaxation.

This perfectly planned road trip itinerary in Italy takes you through some of the best places to see in the country. You will spend 2 nights in Perugia, 3 nights in Rome, 2 nights in Naples, 1 night in Viterbo, and 1 night in Pisa. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Italy. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have got you covered.

Upon arriving in Perugia, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Italy on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Italy. Trevi Fountain and Colosseum are just a couple of the bucket-list attractions that await your discovery.

As you hit the open road and drive through Perugia, Pissignano, Rome, Naples, Ravello, Amalfi, Tivoli, Viterbo, Pisa, and Siena, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Italy. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Italy.

Throughout your road trip in Italy, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Italy.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodation, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in Italy fill up quickly, so book your spot early. Select a date and start planning your road trip in Italy today!

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Itinerary summary

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Days
Destination
Attractions
Overnight
Day
City & Overnight
Attractions
Piazza IV Novembre
Rocca PaolinaBorgo di RasigliaFonti del ClitunnoEtruscan Arch
ColosseumRoman ForumPantheonPiazza NavonaCastel Sant'AngeloTrevi Fountain
Villa Borghesepiazza del PopoloSpanish StepsPiazza di SpagnaTrevi Fountain
Altare della PatriaSt Peter's BasilicaSistine ChapelVatican MuseumsTrevi Fountain
Villa RufoloAmalfi CoastOvo CastleCastel Sant'ElmoCappella Sanseveropiazza del Plebiscito

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Day 1

Day 1 – Perugia - arrival day

  • Perugia - Arrival day
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  • Piazza IV Novembre
  • More

Your road trip adventure in Italy begins as soon as you reach Perugia and pick up your car. You’ll stay in Perugia for 1 night and explore the best things to see and do, sample the local cuisine, and choose from a curated selection of the best hotels and places to stay in the city.

Perugia is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out Piazza Iv Novembre or taking a stroll in the city center. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

Find your way to your hotel in Perugia. We recommend choosing a hotel in a central location for easy exploring. Check-in typically starts between 2 and 4 PM at hotels in Italy. Settle in and make plans for the evening.

As dinnertime approaches, it's time to head out for a bite to eat in Perugia. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.

Make sure to reserve a table at Ristorante Settimo Sigillo, an iconic dining spot in Perugia. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Caffè Baglioni, a popular restaurant in Perugia. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of Bar Pellas, a hidden gem nestled in Perugia. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

Let the evening flow smoothly from dinner to drinks at Tommi Bar, a top-rated bar in the area. For other recommendations, Valentina provides a perfect setting for rounding out your night with style and great drinks. Likewise, Caffe Dal Perugino offers a memorable night with diverse drink options and excellent service.

Raise a toast to the start of your 10-day road trip in Italy!

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Day 2

Day 2 – Perugia, Rasiglia, Pissignano, and Rome

  • Perugia
  • Pissignano
  • Rome
  • More

Drive 234 km, 3 hours 34 min

  • Rocca Paolina
  • Borgo di Rasiglia
  • Fonti del Clitunno
  • Etruscan Arch
  • More

On day 2 of your road trip in Italy, you will get a true taste of the freedom a self-drive vacation in Europe entails. Today’s travel plans include stops at the most scenic, wondrous, and interesting places in Perugia, Rasiglia, and Pissignano. In the evening, you’ll end up in Rome, where you will stay for 3 nights.

Just a short distance away is Etruscan Arch, a breathtaking historical landmark that draws visitors from far and near.

Rasiglia’s wonders await as you prepare for another journey on the road, leaving the breathtaking surroundings of Perugia behind. This drive usually takes around 51 min. Rasiglia welcomes you with a multitude of unique vacation experiences.

Take your self-guided tour to Borgo Di Rasiglia, a worthwhile historical landmark that everyone visiting Rasiglia should see. Enjoy sightseeing at your own pace and allow yourself time to explore the beautiful surroundings.

Pissignano’s wonders await as you prepare for another journey on the road, leaving the breathtaking surroundings of Rasiglia behind. This drive usually takes around 34 min. Pissignano welcomes you with a multitude of unique vacation experiences.

Begin your journey at Clitumnus and explore the romantic features.

At the end of the day, you will drive to Rome, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

As you explore more of Rome, you'll discover that its culinary landscape is as diverse as its attractions. Whether you're craving traditional dishes bursting with local flavors or innovative creations that push the boundaries of taste, you're sure to find a dining experience that satisfies your cravings.

Experience a taste of local culinary excellence while in Rome by securing a table at La Pergola. An esteemed 3-star Michelin restaurant, it features an exceptional mediterranean and contemporary menu. For an alternative taste experience, visit Il Pagliaccio, famous for its scrumptious creative and innovative dishes. This 2-star Michelin venue consistently impresses guests, making it a standout addition to your holiday plans. Looking for another choice? Discover Enoteca La Torre, a local favorite celebrated for its exquisite mediterranean and creative cuisine in Rome. Located in the heart of the city, this 2-star Michelin restaurant is an ideal pick for mediterranean and creative cuisine lovers seeking top-notch culinary experiences.

Extend your evening after a delightful meal by visiting La Botticella Of Poggi Giovanni, which offers the perfect atmosphere for a night out. Moreover, Almalu Trastevere is another popular option for a drink or two. Likewise, Bar Viminale Di Pepi Maurilio also provides a great ambiance for reminiscing about the day and raising a toast to your vacation.

Get a good night's sleep and look forward to another great day on the road in Italy!

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Day 3

Day 3 – Rome

  • Rome
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Drive 9 km, 1 hour 11 min

  • Colosseum
  • Roman Forum
  • Pantheon
  • Piazza Navona
  • Castel Sant'Angelo
  • Trevi Fountain
  • More

On day 3 of your road trip, you will have an entire day to explore Rome. You’ll stay in Rome for 2 nights and discover all the best things to see and do in the area.

Enjoy the perfect balance of relaxation and exploration in Rome today. One of the most wondrous attractions included on the itinerary is Colosseum. This culturally significant archeological site will help you start your sightseeing on top. Then, take a leisurely stroll to Roman Forum and learn what makes this breathtaking archeological site unique.

Throughout the day, make sure to take breaks to appreciate the surroundings. Next up, visit the timeless Pantheon. After exploring the monument, head to Piazza Navona. This wondrous public square is a highlight in Rome. Lastly, don’t forget to check out the impressive Castel Sant'angelo. Enjoy exploring this incredible castle at your own pace.

Don’t forget to check out all the popular tours and activities you can add to your travel plan. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.

After a day of adventure, treat yourself to an exquisite dinner at one of Rome's best restaurants.

Have a fantastic dining experience at RomAntica, a highly recommended choice for tonight's dinner. If you're looking to mix things up, Coso Ristorante offers an enticing alternative with its varied menu. Additionally, DEROMA - Farine Romane is worth considering. Renowned for satisfying diners, it’s an ideal option for tonight in Rome.

Keep the evening going at Sant' Eustachio Caffè, a great choice for enjoying the after-dinner hours with a drink. You could also go to Yellowsquare Rome, which offers a similarly pleasant setting and great drinks. Another option is Caffè Portofino, which provides an inviting environment for unwinding after a busy day out.

Savor another day of unforgettable experiences in Italy!

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Day 4

Day 4 – Rome

  • Rome
  • More

Drive 7 km, 59 min

  • Villa Borghese
  • piazza del Popolo
  • Spanish Steps
  • Piazza di Spagna
  • Trevi Fountain
  • More

Day 4 offers a multitude of experiences. You will stay in Rome for 1 night more, offering you enough time to explore at a relaxed pace.

Rome is brimming with adventures. Today’s wonderful stops include a park and a public square. Begin your sightseeing adventure at the famous Villa Borghese. Just a short distance away is Piazza Del Popolo, a grand public square that draws visitors from far and near.

Continue your journey to Spanish Steps, one of the city’s most widely recognized spots that you shouldn’t miss. Another great site to visit is the timeless Piazza Di Spagna.

Don’t forget to check out all the popular tours and activities you can add to your travel plan. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.

As dinnertime approaches, it's time to head out for a bite to eat in Rome. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.

Enjoy a delicious meal at Hotel de Russie, a highly-rated dining destination in Rome. If you're eager to try something different, consider La Taverna Italiana, another top spot with a tantalizing menu. You might also want to secure a reservation at The Parrot Bar. With a reputation for consistently satisfying customers, it’s an excellent choice to enhance your stay in Rome this evening.

Following your dinner, dive into the local bar culture at The Apartment Bar Roma. Enjoy this evening's relaxed ambiance with delightful drinks. Alternatively, go to Hotel Hassler Roma, the perfect place for those looking to experience the best of the nightlife.

Raise your glass to another unforgettable day in Italy!

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Day 5

Day 5 – Rome, Vatican City, and Naples

  • Rome
  • Naples
  • More

Drive 236 km, 3 hours 14 min

  • Altare della Patria
  • St Peter's Basilica
  • Sistine Chapel
  • Vatican Museums
  • Trevi Fountain
  • More

Dive into day 5 of your remarkable road trip in Italy. Today you will explore Rome and Vatican City, where you will have the opportunity to experience all the top things to see and do. At the end of the day, you’ll unwind at one of the finest accommodations in Naples. You’ll stay here for 2 nights.

Immerse yourself in Rome’s rich culture with today's sightseeing itinerary. Start your journey at Altare Della Patria. This historic monument is sure to ignite your curiosity.

As you’ve unraveled the marvels of Rome, it’s time to gear up for the next part of your road trip adventure. Set course for Vatican City! Under favorable conditions, your drive to Vatican City may take around 11 min. Upon your arrival in Vatican City, you’ll be greeted with the opportunity to do some sightseeing and exploring.

Head to St. Peter's Basilica, a timeless major basilica in Vatican City. This famous chapel is a top recommendation in the area. When you’re ready to explore more, Vatican Museums is an excellent choice.

After soaking up all the sights of today's itinerary, you'll be ready to hit the road in the direction of your accommodation in Naples. Naples offers plenty of top-rated hotels and other places to stay on any travel budget. Take some time to relax before you head out to explore.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Naples. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Start your culinary exploration in Naples by securing a reservation at Veritas. This renowned restaurant holds 1 Michelin star and offers an exceptional menu of campanian and contemporary cuisine. For another dining delight, visit Il Comandante, celebrated for its delectable creative and mediterranean menu. This acclaimed 1-star Michelin-recipient consistently leaves guests satisfied, making it a must-visit during your holiday. Looking for a different experience? Discover ARIA, a top local spot known for its tantalizing contemporary and modern menu. With a 1-star Michelin recognition, it guarantees an exceptional dining adventure.

After your delicious meal, get a taste of the vibrant nightlife with a visit to Happening Cocktail Bar, known for its inviting atmosphere. Shanti Art Musik Bar is another great option if you’re looking for a place to get the night started. Similarly, Gran Caffè Gambrinus provides a great setting to enjoy the night away.

Celebrate another amazing day of your road trip adventure in Italy!

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Day 6

Day 6 – Naples, Ravello, and Amalfi

  • Naples
  • Ravello
  • Amalfi
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Drive 144 km, 4 hours 4 min

  • Villa Rufolo
  • Amalfi Coast
  • Ovo Castle
  • Castel Sant'Elmo
  • Cappella Sansevero
  • piazza del Plebiscito
  • More

Greet day 6 of your road trip in Italy with a smile and start your day with a hearty breakfast. You will return to Naples for your remaining 1 night in the city later today, but first, it’s time for some exploring! On the agenda for this day, you’ll find only the best things to see and do in Ravello, Amalfi, and Naples.

Discover a day packed with a charming, an enchanting, a visually striking, a history-steeped, a grand, and a detailed in Naples. Begin your sightseeing with Ovo Castle. This popular castle is one of the top attractions in the village. Proceed to Castel Sant'elmo, another must-visit attraction that enhances the village’s allure.

As you wander through the inviting streets of Naples, soak in the lively ambiance and take the opportunity to snap some photos. Next, head to Cappella Sansevero. This well-known museum is a traveler-favorite. Not far away, you’ll find Piazza Del Plebiscito, another key site on your sightseeing itinerary.

Set your GPS to Ravello and hit the road. Expect a journey of approximately 1 hour 10 min without stops. Soak in the beautiful landscapes as you drive and look forward to exploring your next destination. Ravello beckons with new experiences!

Villa Rufolo is a popular historical landmark we recommend making time to visit today. Discover its enchanting features before continuing your self-guided tour.

When you’re done exploring the area’s best attractions, you’ll drive back to your accommodation in Naples.

After a day of adventure, treat yourself to an exquisite dinner at one of Naples's best restaurants.

Enjoy a lovely meal at Antica Pizzeria Di Matteo, a top-rated place to have dinner tonight. Alternatively, if your taste buds call for something different, Mercure Napoli Centro Angioino is another top choice with a popular menu. You could also check for a table at La Lazzara Trattoria e Pizzeria. As an establishment that gains consistently high praises from customers, it’s an ideal choice in Naples tonight.

Keep the evening going at Archivio Storico - Cocktail Bar & Wonderfood, a great choice for enjoying the after-dinner hours with a drink. You could also go to Archeobar, which offers a similarly pleasant setting and great drinks. Another option is Babette Pub, which provides an inviting environment for unwinding after a busy day out.

Raise your glass and celebrate another amazing day of your road trip in Italy!

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Day 7

Day 7 – Naples, Tivoli, and Viterbo

  • Naples
  • Tivoli
  • Viterbo
  • More

Drive 330 km, 4 hours 4 min

  • piazza del Plebiscito
  • Naples National Archaeological Museum
  • Villa d'Este
  • Fontana dell'Ovato (o di Tivoli)
  • More

On day 7 of your exciting self-drive vacation in Italy, you’ll soak in the magnificence of 2 destinations, Naples and Tivoli. When you’re not sightseeing, take time to relax at your selected hotel in Viterbo, where you’ll be staying for 1 night.

Start by visiting Naples National Archaeological Museum, a prime spot to begin your journey. This standout museum is sure to impress.

Set your GPS to Tivoli and hit the road. Expect a journey of approximately 2 hours 18 min without stops. Soak in the beautiful landscapes as you drive and look forward to exploring your next destination. Tivoli beckons with new experiences!

Spend your afternoon discovering Villa D'este, a well-known palace known for its romantic features. After taking in the atmosphere, continue to Fontana Dell'ovato (o Di Tivoli), an underrated monument that is a must-see for anyone visiting the region.

When you’re done exploring for the day, you’ll drive to your hotel in Viterbo. Check in and spend some time relaxing before you head out to tour the city.

Indulge in a memorable dining experience at one of Viterbo's most popular restaurants, and connect with friendly locals for an authentic adventure.

Relax and recharge in preparation for another adventurous day in Italy!

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Day 8

Day 8 – Viterbo and Pisa

  • Viterbo
  • Pisa
  • More

Drive 274 km, 3 hours 32 min

  • Palazzo dei Papi di Viterbo
  • Cattedrale di San Lorenzo
  • Terme dei papi
  • More

Experience an unparalleled adventure on day 8 of your road trip in Italy. This exciting part of your journey invites you to discover the renowned landmarks in 1 vibrant destinations - Viterbo. After a day filled with exploration and new experiences, you will retreat to the hotel of your choice in Pisa. You will spend 1 night here for some well-deserved relaxation.

A blend of an awe-inspiring, a photogenic, a respected, a majestic, a monumental, and a romantic await you in Viterbo on today’s itinerary. First up is the frequently visited palace, Palazzo Dei Papi Di Viterbo. It's a standout spot that offers a memorable visit. Afterward, continue to Cattedrale Di San Lorenzo. A visit to this church is an enriching experience for all.

As you explore Viterbo’s charming streets, take in the lively atmosphere and get to know the character of the city. Next, make your way to Terme Dei Papi. This often recommended spa is an essential stop that should not be missed.

At the end of the day, you will drive to Pisa, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

As dinnertime approaches, it's time to head out for a bite to eat in Pisa. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.

Have a fantastic dining experience at Anima di Grano Pizzeria Napoletana Pisa Italy, a highly recommended choice for tonight's dinner. If you're looking to mix things up, il Mercante offers an enticing alternative with its varied menu. Additionally, La Ghiotteria is worth considering. Renowned for satisfying diners, it’s an ideal option for tonight in Pisa.

Let the evening flow smoothly from dinner to drinks at Jeffer Cocktails & Friends, a top-rated bar in the area. For other recommendations, Le Parisien Wine Bar provides a perfect setting for rounding out your night with style and great drinks. Likewise, Las Volta Cocktailbar offers a memorable night with diverse drink options and excellent service.

Raise your glass to another unforgettable day in Italy!

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Day 9

Day 9 – Pisa, Siena, and Perugia

  • Pisa
  • Siena
  • Perugia
  • More

Drive 235 km, 3 hours 35 min

  • Leaning Tower of Pisa
  • Piazza del Duomo, Pisa
  • Siena Cathedral
  • piazza del Campo
  • More

Embark on another extraordinary experience on day 9 of your road trip in Italy. Today, you will make 2 stops and experience some of the highlights of Pisa and Siena. At the end of the day, you will enjoy the comforts of a top-rated hotel in Perugia, which will be your home away from home for 1 night.

Enjoy the perfect balance of relaxation and exploration in Pisa today. One of the most iconic attractions included on the itinerary is Leaning Tower Of Pisa. This masterful monument will help you start your sightseeing on top. Then, take a leisurely stroll to Piazza Del Duomo, Pisa and learn what makes this stunning public square unique.

Throughout the day, make sure to take breaks to appreciate the surroundings.

Embrace the thrill of the open road as you wave goodbye to Pisa and set your GPS to Siena. While on the road, immerse yourself in your favorite road trip tunes or sample the sounds from a local radio station. This car ride usually takes around 1 hour 50 min. Upon reaching Siena, unwind, observe, and explore. The best things to do, see, and eat are waiting for you.

Make your way to Siena Cathedral, an interesting church that draws attention for its grand features. Spend some time soaking in the atmosphere before continuing to Piazza Del Campo, a history-steeped public square that stands out in the city.

After soaking up all the sights of today's itinerary, you'll be ready to hit the road in the direction of your accommodation in Perugia. Perugia offers plenty of top-rated hotels and other places to stay on any travel budget. Take some time to relax before you head out to explore.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Perugia. Enjoy a relaxing evening as you savor delicious local cuisine and reflect on the day's adventures.

Don’t miss out on dining at La Taverna, a top-rated dining destination in Perugia. If you're in the mood to try something new, consider Ristorante del Sole, another top spot with a mouthwatering menu. You might also want to secure a reservation at Al Mangiar Bene. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Perugia this evening.

Cap off your dinner by heading to Caffè Fortebraccio, ideal for a leisurely evening with a drink in hand. Caffe Del Banco is another bar that offers an enjoyable setting. Similarly, Dempsey's Perugia is also a popular place to go on a night out, perfect for relaxing and socializing.

As the day draws to a close, take a moment to unwind and prepare for the next exciting chapter of your road trip in in Italy.

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Day 10

Day 10 – Perugia - departure day

  • Perugia - Departure day
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  • Etruscan Arch
  • More

Day 10 of your road trip in Italy is your departure day. This is your chance to catch a last glimpse of Perugia before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

As your final day in Italy unfolds, enjoy a last-minute shopping spree in Perugia's best shopping area. Enjoy finding the perfect gift or keepsake to remind you of your wonderful trip to Italy.

Before you conclude your road trip in Italy, drop by another restaurant for a last chance at a memorable dining experience in Perugia.

If you're in the mood to try something new, consider Elfo Pub Perugia, another top spot with a mouthwatering menu.

You’ll then say farewell to Perugia. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Italy!

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