10-Day Italy Road Trip from Pisa traveling south to Florence, Rome, and Arezzo

Your road trip adventure in Italy begins as soon as you reach Pisa and pick up your car. You’ll stay in Pisa for 1 night and explore the best things to see and do, sample the local cuisine, and choose from a curated selection of the best hotels and places to stay in the city.

Pisa is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out Logge dei Banchi or taking a stroll in the city center. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

Find your way to your hotel in Pisa. We recommend choosing a hotel in a central location for easy exploring. Check-in typically starts between 2 and 4 PM at hotels in Italy. Settle in and make plans for the evening.

As dinnertime approaches, it's time to head out for a bite to eat in Pisa. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.

Have a fantastic dining experience at Ristorante Capodimonte Pisa, a highly recommended choice for tonight's dinner. If you're looking to mix things up, Baribaldi Pisa offers an enticing alternative with its varied menu. Additionally, Restaurant -Pizzeria Il Mio Capriccio is worth considering. Renowned for satisfying diners, it’s an ideal option for tonight in Pisa.

Keep the evening going at JEFFER cocktails & friends, a great choice for enjoying the after-dinner hours with a drink. You could also go to Le Parisien Wine Bar, which offers a similarly pleasant setting and great drinks. Another option is Las Volta cocktailbar, which provides an inviting environment for unwinding after a busy day out.

Raise a toast to the start of your 10-day road trip in Italy!

Embark on another extraordinary experience on day 2 of your road trip in Italy. Today, you will make 2 stops and experience some of the highlights of Pisa and Cascine Vecchie. At the end of the day, you will enjoy the comforts of a top-rated hotel in Florence, which will be your home away from home for 2 nights.

Journey into the unknown at Knights' Square, a unique attraction awaiting your visit. This remarkable square has an average rating of 4.5 out of 5 stars from 9,051 reviews.

When you’re ready to continue your sightseeing, Leaning Tower of Pisa is a recommended place to visit. This bell tower is rated an average of 4.7 out of 5 stars in 116,882 reviews. Based on recent data, the attraction hosts 3,200,000 visitors per year.

Another must-see attraction in Pisa is Piazza del Duomo, Pisa. Rated an average of 4.7 out of 5 stars by 104,550 travelers, this popular tourist destination in Pisa offers an experience you will remember.

Pisa Cathedral is another popular stop on travelers' itineraries in Pisa. This cathedral promises memorable moments of exploring. Other travelers have rated this attraction 4.8 out of 5 stars in 8,361 reviews.

Be one of the day’s first visitors at Parco Regionale Migliarino, San Rossore, Massaciuccoli. This park is rated an average of 4.4 out of 5 stars by 9,632 visitors.

After soaking up all the sights of today's itinerary, you'll be ready to hit the road in the direction of Florence. Florence offers plenty of top-rated hotels and other places to stay on any travel budget. Check in at the hotel of your choice and take some time to relax before you head out to explore.

After a day of adventure, treat yourself to an exquisite dinner at one of Florence's best restaurants.

Have a memorable dining experience in Florence by booking a table at Enoteca Pinchiorri, renowned as a 3-star Michelin restaurant presenting an exceptional italian contemporary menu. For a different culinary experience, Santa Elisabetta shines as one of the top destinations known for its delicious creative and mediterranean cuisine in Florence. This 2-star Michelin-awardee earns consistently high praises from previous guests, making it a must-visit addition to your holiday experience. If you're looking for an alternative, Gucci Osteria da Massimo Bottura is known as a top local spot for its delicious italian contemporary and international cuisine in Florence. This 1-star Michelin awardee is a highly recommended choice for an unforgettable meal.

Keep the evening going at Manifattura, a great choice for enjoying the after-dinner hours with a drink. You could also go to SE·STO on Arno Rooftop Bar, which offers a similarly pleasant setting and great drinks. Another option is Archea Brewery, which provides an inviting environment for unwinding after a busy day out.

Raise your glass to another unforgettable day in Italy!

Day 3 offers a multitude of experiences. You will stay in Florence for 1 night more, offering you enough time to explore at a relaxed pace.

Kick off the day at piazzale Michelangelo, a top pick for today’s sightseeing. This square is rated an average of 4.8 out of 5 stars in 77,744 reviews.

Today is also your chance to visit Uffizi Gallery. Uffizi Gallery is a national museum with an average rating of 4.7 out of 5 stars from 61,794 reviews. Attracting more than 2,011,219 yearly visitors, this place of interest is an attraction you don’t want to miss out on.

Ponte Vecchio is another top attraction we highly recommend you visit today. This deck arch bridge is rated an average of 4.7 out of 5 stars by 118,099 visitors.

Beyond the attractions mentioned above, you also have the opportunity to visit piazza della Signoria. This square is rated an average of 4.8 out of 5 stars by 66,956 visitors.

Lastly, don’t miss out on Cathedral of Santa Maria del Fiore, a famous church in Florence. This attraction is rated an average of 4.8 out of 5 stars by 76,359 travelers.

There are plenty of experiences you can choose from in Italy that will add excitement to your vacation. When you’re keen to discover what else Florence has in store for you, use this day to go on a tour. This tour allows curious travelers like you to experience the best of the country. You can make the most of your time in Italy by scrolling down and selecting tours and activities to include on your itinerary for the day.

As you explore more of Florence, you'll discover that its culinary landscape is as diverse as its attractions. Whether you're craving traditional dishes bursting with local flavors or innovative creations that push the boundaries of taste, you're sure to find a dining experience that satisfies your cravings.

Have a fantastic dining experience at Trattoria Da Burde, a highly recommended choice for tonight's dinner. If you're looking to mix things up, Ristorante Buca Mario offers an enticing alternative with its varied menu. Additionally, Eataly Firenze is worth considering. Renowned for satisfying diners, it’s an ideal option for tonight in Florence.

Raise your glass and celebrate another amazing day of your road trip in Italy!

On day 4 of your road trip in Italy, you will get a true taste of the freedom a self-drive vacation in Europe entails. Today’s travel plans include stops at the most scenic, wondrous, and interesting places in Orvieto. In the evening, you’ll end up in Rome, where you will stay for 4 nights.

As you’ve unraveled the marvels of Florence, it’s time to gear up for the next part of your road trip adventure. Under favorable conditions, your drive to Orvieto may take around 1 hour 54 min. Upon your arrival in Orvieto, you’ll be greeted with the opportunity to do some sightseeing and exploring.

Start your sightseeing with a visit to Well of St. Patrick. This point of interest is rated an average of 4.5 out of 5 stars from 14,274 visitors.

Once you're ready to continue your road trip, it's time to buckle up and drive, eagerly anticipating your arrival in Orvieto. This drive usually takes around 1 hour 54 min, without any stops or traffic disruptions.

When you’re ready for some sightseeing, make your way to Orvieto Cathedral. This much-appreciated catholic cathedral is rated 4.8 out of 5 stars in 15,057 reviews.

Next up is Orvieto Underground. This archaeological site has an average rating of 4.6 out of 5 stars from 1,517 visitors. As one of the top places to visit in the village, Orvieto Underground welcomes 37,000 visitors annually.

Another top sightseeing recommendation is Pozzo della Cava. This objet du musée d'archéologie has been rated 4.6 out of 5 stars in 1,403 reviews. Every year, 20,336 travelers include this attraction on their travel itinerary.

At the end of the day, you will drive to Rome, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

Indulge in a memorable dining experience at one of Rome's most popular restaurants, and connect with friendly locals for an authentic adventure.

Start your culinary exploration in Rome by securing a reservation at La Pergola. This renowned restaurant holds , and offers an exceptional menu of mediterranean and contemporary cuisine. For another dining delight, visit Il Pagliaccio, celebrated for its delectable creative and innovative menu. This acclaimed 2-star Michelin-recipient consistently leaves guests satisfied, making it a must-visit during your holiday. Looking for a different experience? Discover Enoteca La Torre, a top local spot known for its tantalizing mediterranean and creative menu. With a 2-star Michelin recognition, it guarantees an exceptional dining adventure.

To truly maximize your evening out, consider visiting La Botticella of Poggi Giovanni after dinner. This bar is known for offering some of the best drinks and vibes in the city. Alternatively, head to Sant' Eustachio Caffè, another bar with an inviting ambiance. Similarly, Caffè Portofino also offers a great atmosphere, ensuring a night filled with enjoyment and relaxation.

As the day draws to a close, take a moment to unwind and prepare for the next exciting chapter of your road trip in in Italy.

Day 5 of your road trip will take you to the best attractions Rome has to offer. Cherish the 3 nights you have left in Rome by discovering the best things there are to see and do in the city.

An excellent attraction to start your day with is Basilica di Santa Maria Maggiore. This major basilica is rated an average of 4.8 out of 5 stars in 27,678 reviews.

Continue your journey at Colosseum. This roman amphitheatre is rated 4.7 out of 5 stars by 328,821 travelers from near and far. Approximately 7,400,000 people come to this place of interest every year to enjoy a unique experience in Rome.

Rome is also the home of Roman Forum. This square has an average rating of 4.7 out of 5 stars from 114,450 visitors.

You can continue your self-guided sightseeing tour at largo di Torre Argentina. Rated 4.5 out of 5 stars by 30,433 visitors, a visit to this top sight is time well spent.

Lastly, don't miss out on Pantheon. With an average rating of 4.8 out of 5 stars from 189,682 reviews, it’s hard to refuse the opportunity to see this roman temple. Approximately 30,000,000 people visit this attraction every year.

If you have an appetite for more adventure, check out the fantastic selection of tours and tickets offered in Rome on this day of your trip. You'll find the most recommended ones below.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Rome. Enjoy a relaxing evening as you savor delicious local cuisine and reflect on the day's adventures.

Savor the flavors at DEROMA - Farine Romane, a top pick for dinner tonight. Alternatively, La Taverna Italiana beckons with its unique menu offerings. Also, consider Centro. With its consistent customer satisfaction, it’s an excellent option for dining in Rome tonight.

Continue the enjoyment post-dinner at The Apartment Bar Roma, a cherished local gathering spot renowned for its welcoming atmosphere. Similarly, Hotel Hassler Roma offers a vibrant space for indulging in well-crafted drinks and engaging conversation.

Celebrate another amazing day of your road trip adventure in Italy!

Day 6 of your road trip across Italy promises a magnificent time exploring Rome. You have 2 nights left in Rome. Take the opportunity to experience more of the best attractions and activities in the city.

Begin your sightseeing with a visit to Circus Maximus. This circus is rated an average of 4.4 out of 5 stars in 44,741 reviews.

Next up, make your way to Altare della Patria. This architectural structure has an average rating of 4.8 out of 5 stars from 49,843 reviews. Usually, around 1,683,070 people visit Altare della Patria every year.

When you’re ready for your next sight of the day, continue to Trevi Fountain. This sculpture has an average rating of 4.8 out of 5 stars from 343,494 visitors.

Beyond the above-mentioned attractions, you also have the opportunity to visit Piazza di Spagna. This square is rated an average of 4.7 out of 5 stars by 113,658 visitors.

If you’re keen to explore even more, then consider a visit to Spanish Steps. This monumental staircase is a much-appreciated attraction with an average rating of 4.5 out of 5 stars from 57,211 visitors.

To do something one-of-a-kind on this day of your trip, you can join a tour. You can discover all of the most fun and eye-opening experiences in your destination below and secure your spot here.

As dinnertime approaches, it's time to head out for a bite to eat in Rome. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.

Don’t miss out on dining at Ristorante Tema, a top-rated dining destination in Rome. If you're in the mood to try something new, consider Maccheroni, another top spot with a mouthwatering menu. You might also want to secure a reservation at RoYaL Art Cafè Roma. With a reputation for consistently satisfied customers, it’s a perfect choice to enhance your stay in Rome this evening.

Raise your glass to another unforgettable day in Italy!

On day 7 of your road trip, you will have an entire day to explore Rome. You’ll stay in Rome for 1 night and discover all the best things to see and do in the area.

Journey into the unknown at Villa Borghese, a unique attraction awaiting your visit. This remarkable urban zone of rome has an average rating of 4.6 out of 5 stars from 69,749 reviews.

When you’re ready to continue your sightseeing, piazza del Popolo is a recommended place to visit. This square is rated an average of 4.6 out of 5 stars in 89,807 reviews.

Another must-see attraction in Rome is Castel Sant'Angelo. This spectacular museum gets over 918,591 visitors every year. Rated an average of 4.7 out of 5 stars by 72,431 travelers, this popular tourist destination in Rome offers an experience you will remember.

Piazza Navona is another popular stop on travelers' itineraries in Rome. This square promises memorable moments of exploring. Other travelers have rated this attraction 4.7 out of 5 stars in 158,771 reviews.

Lastly, don't miss out on Campo de' Fiori. Rated 4.4 out of 5 stars by 51,133 local and international travelers, it's a popular place to visit.

Your discoveries in Rome do not have to stop there. Check out the fantastic selection of tours and tickets offered in Rome on this day of your trip. You can select your tours below.

After a day of adventure, treat yourself to an exquisite dinner at one of Rome's best restaurants.

Enjoy a delicious meal at Harry's Bar, a top-rated dining destination in Rome. If you're in the mood to try something new, consider Ristorante Amedeo, another top spot with a mouthwatering menu. You might also want to secure a reservation at VinAllegro. With a reputation for consistently satisfied customers, it’s a perfect choice to enhance your stay in Rome this evening.

Get a good night's sleep and look forward to another great day on the road in Italy!

On day 8 of your exciting self-drive vacation in Italy, you’ll soak in the magnificence of 1 destination, Vatican City. When you’re not sightseeing, take time to relax at your selected hotel in Arezzo, where you’ll be staying for 1 night.

Continue your road trip and head to your next destination, Vatican City.

When you're ready to see some sights, St. Peter's Basilica is a great place to start. This major basilica is rated an average of 4.8 out of 5 stars by 131,043 visitors. St. Peter's Basilica attracts more than 11,000,000 visitors every year.

Another popular attraction you can visit today is Sistine Chapel. This chapel has an average rating of 4.7 out of 5 stars from 52,083 travelers.

We also recommend a stop at Saint Peter's Square. The square has been rated an average of 4.8 out of 5 stars by 38,954 visitors.

If you're keen to explore more, consider visiting Vatican Museums. This art museum is a popular attraction with an average rating of 4.6 out of 5 stars from 133,310 reviews. As a top-rated attraction, it's no surprise that 1,612,530 people visit Vatican Museums every year.

When you’re done exploring for the day, you’ll drive to Arezzo, where you'll have a hotel waiting for you. Check in and spend some time relaxing before you head out to explore the city.

As you explore more of Arezzo, you'll discover that its culinary landscape is as diverse as its attractions. Whether you're craving traditional dishes bursting with local flavors or innovative creations that push the boundaries of taste, you're sure to find a dining experience that satisfies your cravings.

Get ready for an unforgettable culinary journey in Arezzo by reserving a table at Octavin. Renowned as a 1-star Michelin restaurant, it offers an exceptional creative menu. If you're in the mood to try something new, consider La Clandestina, another top spot with a mouthwatering menu. You might also want to secure a reservation at Ristorante Logge Vasari. With a reputation for consistently satisfied customers, it’s a perfect choice to enhance your stay in Arezzo this evening.

After savoring a delicious meal, step into the vibrant nightlife at Liquid Bar, where the evening is just getting started.

Relax and reminisce about your day in Italy and look forward to more memorable moments to come!

Experience an unparalleled adventure on day 9 of your road trip in Italy. This exciting part of your journey invites you to discover the renowned landmarks in 2 vibrant destinations - Siena and Livorno. After a day filled with exploration and new experiences, you will retreat to the hotel of your choice in Pisa. You will spend 1 night here for some well-deserved relaxation.

Siena’s wonders await as you prepare for another journey on the road, leaving the breathtaking surroundings of Arezzo behind. This drive usually takes around 1 hour 4 min. Siena welcomes you with a multitude of unique vacation experiences.

Start your sightseeing with a visit to piazza del Campo. This square is a popular stop on travelers’ itineraries in Siena, with an average rating of 4.8 out of 5 stars by 64,175 visitors.

Siena Cathedral is another popular place of interest you can visit today. The average rating of 4.8 out of 5 stars from 21,656 reviews gives you an idea of other visitors’ experience at this attraction.

If it’s still bright and early, make your way to Fortezza Medicea (Siena). Visitors have rated this fortress an average of 4.5 out of 5 stars in 9,835 reviews.

Continue your road trip and head to your next destination, Livorno. This car ride takes around 1 hour 55 min.

Kick off the day at Terrazza Mascagni, a top pick for today’s sightseeing. This seafront is rated an average of 4.6 out of 5 stars in 21,838 reviews.

After soaking up all the sights of today's itinerary, you'll be ready to hit the road in the direction of Pisa. Pisa offers plenty of top-rated hotels and other places to stay on any travel budget. Check in at the hotel of your choice and take some time to relax before you head out to explore.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Pisa. Enjoy a relaxing evening as you savor delicious local cuisine and reflect on the day's adventures.

Treat yourself to a delightful dinner at Ristorante alle Bandierine, highly recommended for tonight's dining. Or, if you're feeling adventurous, why not try Barrique Cocktail And Bistrot? It's another excellent option with a diverse menu. Consider reserving a table at Filter Coffee Lab as well. Known for its consistent customer satisfaction, it’s an ideal pick for tonight in Pisa.

Continue your lively evening at Bar Mocambo, a perfect place for winding down or revving up the night, depending on which mood you’re in. Tree is another excellent bar that offers a great selection of drinks to suit any mood. If you prefer to go somewhere else, Chupiteria ensures a night out tailored to your taste.

Say good night to Pisa and look forward to another great day of your road trip in Italy!

Day 10 of your road trip in Italy is your departure day. This is your chance to catch a last glimpse of Pisa before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

On your last day in Italy, take time to indulge in shopping at Pisa’s popular marketplace. Thanks to your accommodation’s strategic location, the city’s bustling commercial district is only a stone’s throw away, giving you ample time to leisurely explore the area, filled with local shops.

Take time to find the perfect present, reminding you of the charms of Italy. Each store here is brimming with unique finds. These souvenirs will help you treasure your memories of Italy forever.

When you’re ready for some sightseeing, make your way to Lungarni di Pisa. This much-appreciated point of interest is rated 4.6 out of 5 stars in 662 reviews.

Before you conclude your road trip in Italy, drop by another restaurant for a last chance at a memorable dining experience in Pisa.

Dine in style at Sud, a top recommendation for dinner tonight. Or, for a change of pace, Kiste' - La Pizza Artigianale. It's the second restaurant coming from the tower. Boasts a menu that's sure to impress.

You’ll then say farewell to Pisa. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Italy!