10-Day Italy Self-Drive Road Trip With Itinerary from Rome to Florence and Venice

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Photo of piazza de spagna in Rome, Italy.
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Explore the best of Italy on a remarkable 10-day road trip! Combine exploration with relaxation on a self-drive tour featuring Rome, Florence, Pisa, Riomaggiore, Manarola, Corniglia, Vernazza, Venice, Bologna, and Orvieto.

This perfectly planned road trip itinerary takes you through some of the best places to see in Italy. You will spend 3 nights in Rome, 2 nights in Florence, 2 nights in San Bernardino, and 2 nights in Venice. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Italy. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have you covered.

Upon arriving in Rome, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Italy on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Italy. Trevi Fountain and Colosseum are just a couple of the bucket-list attractions that await your discovery.

As you hit the open road and drive through Rome, Florence, Pisa, Riomaggiore, Manarola, Corniglia, Vernazza, Venice, Bologna, and Orvieto, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Italy. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Italy.

Throughout your road trip in Italy, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Italy.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodations, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in Italy fill up quickly, so book your spot early. Select a date and start planning your road trip in Italy today!

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Driver’s age is 30 - 65
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Day1

Day 1

  • Rome - Arrival day
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  • Palatine Hill
  • More

Say hello to Rome! Your exciting road trip through Italy is just about to start. Navigating the top places to see in the region is a breeze with a car. The rental vehicle of your choice will be ready for pickup upon your arrival in the city. You will stay in Rome for 2 nights before you continue your adventure!

Rome is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out Palatine Hill. Taking a stroll in the city center is a great alternative. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

When you're ready for some downtime, make your way to your chosen hotel. Check-in typically starts between 2 and 4 PM in Rome. Make yourself at home and unwind before heading out again.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Rome, it's often a good idea to reserve a table in advance.

Have a fantastic dining experience at La Bottega Roma, a highly recommended choice for tonight's dinner. If you're looking to mix things up, Pasta In Corso offers an enticing alternative with its varied menu. Additionally, Trattoria Vecchia Roma is worth considering. Renowned for satisfying diners, it’s an ideal option for tonight in Rome.

After savoring a delicious meal, step into the vibrant nightlife at La Botticella Of Poggi Giovanni, where the evening is just getting started. In the same way, Almalu Trastevere offers a unique charm perfect for experiencing the local bar scene in Rome. Bar Viminale Di Pepi Maurilio is another top-recommended bar that is sure to get you into the mood for some dancing and celebrating.

Raise a toast to the start of your 10-day road trip in Italy!

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Day2

Day 2

  • Rome
  • More

Drive 6 km, 1 hour 24 min

  • Colosseum
  • Roman Forum
  • Trevi Fountain
  • Spanish Steps
  • Piazza Navona
  • Trastevere
  • More

Day 2 of your road trip will take you to the best attractions Rome has to offer. Cherish the 1 night you have left in the city and use the provided itinerary to discover what to see in Rome.

Trastevere is one of the highlights of today. Take your time exploring this iconic neighborhood in Rome, which offers a perfect blend of history and culture. Plus, it's close to many must-see landmarks in the city.

Colosseum brings Rome's character to life. This UNESCO world heritage-designated archeological site is a highlight of any visit in the city. Then, enjoy Roman Forum, another breathtaking attraction that never fails to captivate visitors. Next, head over to Trevi Fountain, one of the city’s most wondrous attractions, known for its history-steeped features.

If you’re looking for more, spend time soaking in the atmosphere of Spanish Steps. This culturally significant public square is frequented by locals and tourists alike. To complete your memorable day, make sure to visit Piazza Navona, a globally renowned public square, and take a stroll around the area.

Don’t forget to check out all the popular tours and experiences you can add to your travel plans in Italy. You can explore and select activities under each day of your itinerary.

For an unforgettable shopping experience, visit Galleria San Pietro, the top shopping destination in Rome. Browse local shops and stores, each offering delightful surprises. Find unique souvenirs or items to take home. After shopping, explore what Galleria San Pietro has to offer, including attractions, essential services, and vibrant community activities.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Rome. Enjoy a relaxing evening as you savor delicious local cuisine.

Enjoy a delicious meal at RomAntica, a top-rated dining destination in Rome. If you're in the mood to try something new, consider Coso Ristorante, another top spot with a mouthwatering menu. You might also want to secure a reservation at DEROMA - Farine Romane. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Rome this evening.

After savoring a delicious meal, step into the vibrant nightlife at Sant' Eustachio Caffè, where the evening is just getting started. In the same way, Yellowsquare Rome offers a unique charm perfect for experiencing the local bar scene in Rome. Caffè Portofino is another top-recommended bar that is sure to get you into the mood for some dancing and celebrating.

Say good night to Rome and look forward to another great day of your road trip in Italy!

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Day3

Day 3

  • Rome
  • Florence
  • More

Drive 281 km, 3 hours 45 min

  • piazzale Michelangelo
  • Basilica of Santa Croce in Florence
  • Uffizi Gallery
  • Ponte Vecchio
  • piazza della Signoria
  • More

Dive into day 3 of your remarkable road trip in Italy. Today you'll explore 1 destination, including Florence. At the end of the day, you’ll unwind at one of the finest accommodations in Florence, where you'll spend 2 nights.

No visit to Rome is complete without Piazzale Michelangelo. This astonishing observation deck is one of the top attractions in the city. Proceed to Basilica Of Santa Croce In Florence, another must-visit attraction.

As you wander through the inviting streets of Rome, soak in the lively ambiance and take the opportunity to snap some photos. Next, head to Uffizi Gallery. This extraordinary art gallery is a traveler-favorite. Not far away, you’ll find Ponte Vecchio, another key site on your sightseeing itinerary. Piazza Della Signoria is yet another highly recommended place to visit nearby, offering plenty to discover for curious travelers.

When you’re done exploring for the day, you’ll drive to your hotel in Florence. Check in and relax before you head out to tour the city.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Florence, it's often a good idea to reserve a table in advance.

Have a fantastic dining experience at Ristorante Oliviero 1962, a highly recommended choice for tonight's dinner. If you're looking to mix things up, Di Poneta Novoli offers an enticing alternative with its varied menu. Additionally, Caffe San Firenze is worth considering. Renowned for satisfying diners, it’s an ideal option for tonight in Florence.

Let the evening flow smoothly from dinner to drinks at Manifattura, a top-rated bar in the area. For other recommendations, Se·sto On Arno Rooftop Bar provides a perfect setting for rounding out your night with style and great drinks. Likewise, Il Vinile offers a memorable night with diverse drink options and excellent service.

Relax and recharge in preparation for another adventurous day in Italy!

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Day4

Day 4

  • Florence
  • More

Drive 4 km, 1 hour 3 min

  • Palazzo Pitti
  • Cathedral of Santa Maria del Fiore
  • Galleria dell'Accademia
  • Central Market
  • Basilica of Santa Maria Novella
  • Oltrarno
  • More

On day 4 of your road trip, you will have an entire day to discover what to see in Florence. You’ll stay in Florence for 1 night.

Florence is brimming with adventures. Oltrarno is a neighborhood that stands out as one of the must-see places in Florence. Take a moment to explore its distinct atmosphere, and don’t miss the popular sightseeing spots just a short walk away.

Catch Pitti Palace before the crowds roll in. This instagrammable palace is sure to ignite your curiosity. Next, dive into the romantic features of Cathedral Of Santa Maria Del Fiore, a must-visit church in the city.

In between sights, stop by local stores, picturesque photo spots, and small eateries. When you’re ready for your next attraction, proceed to Galleria Dell'accademia, a captivating art gallery. For a change of scene, check out Central Market, known for its photogenic features. We also recommend visiting Basilica Di Santa Maria Novella, Firenze (fi). This church is a must for anyone looking to experience the city to the fullest.

Don’t forget to check out all the popular tours and experiences you can add to your travel plans in Italy. You can explore and select activities under each day of your itinerary.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Florence. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Enjoy a lovely dining experience at Ditta Artigianale, a popular restaurant in Florence. This acclaimed establishment has earned the admiration of countless food lovers in the city. Alternatively, experience a taste of Florence at Trattoria Da Burde, another great place to eat. With a menu designed to impress, it promises a journey of flavors that will leave you captivated. A third option to check out is the top-rated Casa Toscana. It’s yet another ideal choice to enhance your time in Florence tonight.

Keep the evening going at Bar 50 Rosso, a great choice for enjoying the after-dinner hours with a drink. You could also go to Bitter Bar, which offers a similarly pleasant setting and great drinks. Another option is Archea Brewery, which provides an inviting environment for unwinding after a busy day out.

Head back to your accommodation in Florence and get some rest to prepare for another magical day of your road trip in Italy.

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Day5

Day 5

  • Florence
  • More

Drive 195 km, 3 hours 15 min

  • Pisa Cathedral
  • Piazza del Duomo, Pisa
  • Leaning Tower of Pisa
  • Knights' Square
  • Lungarni di Pisa
  • Santuario di Nostra Signora di Montenero
  • More

On day 5 of your road trip in Italy, your travel plans include 2 stops at the most scenic, wondrous, and interesting places in the region. Pisa and Riomaggiore are on today's agenda. In the evening, you’ll end up in San Bernardino, where you will stay for 2 nights.

Pisa Cathedral makes a great addition to your morning plans. This beloved church is a historic place to see in Florence. Continue your discovery at Piazza Del Duomo, Pisa, a historic public square with stories to tell.

As you stroll around Florence, take in the distinct atmosphere and learn what makes this city so unique. Maximize your sightseeing with a visit to Leaning Tower Of Pisa. This globally renowned monument offers a picture-perfect encounter with Florence. Next, make your way to Knights' Square to add another highlight to your day. After that, visit Lungarni Di Pisa, a worthwhile street that’s sure to impress. If you’re up for more, end your self-guided sightseeing tour at Nostra Signora Di Montenero, an increasingly popular church in the city. Whether you decide to get entrance tickets for all attractions or you prefer admiring from a distance, amazing experiences await on this day in Florence.

At the end of the day, you will drive to San Bernardino, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

Indulge in a memorable dining experience at one of San Bernardino's most popular restaurants, and connect with friendly locals for a true cultural experience.

Say good night to San Bernardino and look forward to another great day of your road trip in Italy!

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Day6

Day 6

San Bernardino, Riomaggiore, Manarola, Corniglia, and Vernazza

Drive 32 km, 1 hour 50 min

  • Riomaggiore
  • Castle of Riomaggiore
  • Manarola Overlook Viewpoint
  • Cinque Terre National Park
  • Sentiero Monterosso - Vernazza
  • More

On day 6 of your road trip, you’ll start and end your day in San Bernardino, where you still have 1 night left. You'll spend part of the day exploring places of interest outside the immediate hamlet, including Riomaggiore, Manarola, Corniglia, and Vernazza.

Catch Riomaggiore before the crowds roll in. Next, dive into the history-steeped features of Castle Of Riomaggiore, a must-visit castle in the village.

In between sights, stop by local stores, picturesque photo spots, and small eateries. When you’re ready for your next attraction, proceed to Manarola Overlook Viewpoint, an intriguing observation deck. For a change of scene, check out Cinque Terre National Park, known for its serene features. We also recommend visiting Sentiero Monterosso - Vernazza. This hiking area is a must for anyone looking to experience the village to the fullest.

When you’re done exploring the area’s best attractions, you’ll drive back to your accommodation in San Bernardino.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in San Bernardino. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Head back to your accommodation in San Bernardino and get some rest to prepare for another magical day of your road trip in Italy.

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Day7

Day 7

  • Venice
  • More

Drive 390 km, 5 hours 9 min

  • Bridge of Sighs
  • Doge's Palace
  • St Mark's Basilica
  • St Mark's Campanile
  • Piazza San Marco
  • More

Experience an unparalleled adventure on day 7 of your road trip in Italy. This exciting part of your journey invites you to discover the renowned landmarks in 1 place, which are Venice. At the end of the day, you will retreat to the hotel of your choice in Venice, where will spend 2 nights.

Bridge Of Sighs is an ideal stop early in the day. This well-known monument is a must-visit in the city. When you’re ready for your next discovery, continue to Doge's Palace, which may be one of the most romantic places you will experience today.

One of the best things about exploring San Bernardino on a self-guided tour is that you set the pace. There’s plenty of time for detours and discovering hidden gems. When you’re ready for your next stop, make your way to St Mark's Basilica, a notable church in the city. If you’re up for more discoveries, don’t forget to reserve some time for St Mark's Campanile and Piazza San Marco.

After soaking up all the sights on today's itinerary, you'll be ready to head to your accommodation in Venice. Venice offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

Venice is a place where the culinary landscape is as diverse as its attractions. So before the day ends, treat your palate to a taste of local cuisine at one of the best restaurants in Venice.

Dine in style at Bauer Hotel, a top recommendation for dinner tonight. Or, for a change of pace, L'Osteria Le Guglie boasts a menu that's sure to impress. Also, be sure to check out Corner Pub. Known as a local hotspot, it’s a great choice for tonight in Venice.

After enjoying a delightful dinner, why not delve into the vibrant local bar scene? You might want to spend the evening at Al Parlamento, a well-loved spot among locals and tourists. Or, head to The Caffe Rosso. This bar boasts a welcoming environment that is perfect for winding down. You could also continue your night at Adagio, another top-rated place in the area.

As the sun sets, rest up and recharge for the next leg of your road trip in Italy.

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Day8

Day 8

  • Venice
  • More

Drive 4 km, 56 min

  • Santa Maria della Salute
  • Peggy Guggenheim Collection
  • Gallerie dell'Accademia
  • Palazzo Contarini del Bovolo
  • Rialto Bridge
  • Grand Canal
  • More

Day 8 of your road trip across Italy promises a magnificent time exploring what to see in Venice. You have 1 night left in Venice. Take the opportunity to experience more of the best attractions and activities in the city.

Whether you decide to explore Venice on foot, use public transport, or join a guided tour, there are a few attractions you don’t want to miss.

Start your day at Santa Maria Della Salute. This history-steeped church is an increasingly popular place to see in Venice. Then, wander over to Peggy Guggenheim Collection. If visually striking sites excite you, this art gallery will be right up your alley. Nearby, you’ll also find Gallerie Dell'accademia. This photogenic art gallery is a favorite among visitors.

Venice offers plenty to explore, ensuring every moment of your visit is filled with excitement and discovery. If you're up for more, Palazzo Contarini Del Bovolo is a notable spot in the city that will captivate you with its unique charm. When you’re done at the palace, don’t forget to check out the awe-inspiring Rialto Bridge. Take a moment to appreciate the fascinating details of this globally renowned historical landmark. Wrap up your self-guided tour of Venice's top attractions with a visit to Grand Canal.

Don’t forget to check out all the popular tours and experiences you can add to your travel plans in Italy. You can explore and select activities under each day of your itinerary.

Venice is a place where the culinary landscape is as diverse as its attractions. So before the day ends, treat your palate to a taste of local cuisine at one of the best restaurants in Venice.

Savor the flavors at Generator Venice, a top pick for dinner tonight. Alternatively, Nevodi beckons with its unique menu offerings. Also, consider Ristorante La Piazza. With its consistent customer satisfaction, it’s an excellent option for dining in Venice tonight.

Unwind after your meal by stepping into Il Mercante. This venue is celebrated for its extensive drink selections and cozy vibes. Alternatively, The Irish Pub Venezia offers a dynamic and energetic atmosphere for a glass or two. Don’t overlook Ai Stagneri, another top-rated bar in the area.

Savor another day of unforgettable experiences in Italy!

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Day9

Day 9

  • Venice
  • Rome
  • More

Drive 555 km, 6 hours 36 min

  • Two Towers
  • Palazzo del Podestà, Bologna
  • Piazza Maggiore
  • Torre dell'Orologio
  • Orvieto Cathedral
  • More

Your itinerary for day 9 of your road trip in Italy includes 2 stops and features some of the highlights of Bologna and Orvieto. At the end of the day, enjoy the comforts of a top-rated hotel in Rome, where you'll spend 1 night.

Catch Two Towers before the crowds roll in. This picture-perfect monument is sure to ignite your curiosity. Next, dive into the photogenic features of Palazzo Del Podestà, Bologna, a must-visit palace in the city.

In between sights, stop by local stores, picturesque photo spots, and small eateries. When you’re ready for your next attraction, proceed to Piazza Maggiore, a widely recognized public square. For a change of scene, check out Torre Dell'orologio, known for its culturally significant features. We also recommend visiting Orvieto Cathedral. This church is a must for anyone looking to experience the city to the fullest.

When you’re done exploring for the day, you’ll drive to your hotel in Rome. Check in and relax before you head out to tour the city.

After a day of adventure, treat yourself to an exquisite dinner at one of Rome's best restaurants.

Enjoy a delicious meal at Hotel de Russie, a top-rated dining destination in Rome. If you're in the mood to try something new, consider La Taverna Italiana, another top spot with a mouthwatering menu. You might also want to secure a reservation at The Parrot Bar. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Rome this evening.

After enjoying a fulfilling meal, continue your evening at The Apartment Bar Roma, ideal for those looking to unwind with a drink in a comfortable setting. Alternatively, Hotel Hassler Roma offers a welcoming atmosphere for easing into the nightlife.

Take some time to reflect on your day and savor another beautiful night in Italy.

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Day10

Day 10

  • Rome - Departure day
  • More
  • Pantheon
  • More

Day 10 of your road trip in Italy is your departure day. This is your chance to catch a last glimpse of Rome before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

If you're up for some more sightseeing, we recommend visiting Pantheon, a heritage-rich monument before you head out.

For a shopping spree in Rome, we recommend the lively Via del Corso. Here, you'll find a range of shops you can browse for some souvenir shopping.

Before you conclude your road trip in Italy, drop by another restaurant for a last chance at a memorable dining experience in Rome.

You’ll then say farewell to Rome. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Italy!

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Shortly after booking, you’ll receive your full itinerary, including schedules, locations, and everything you need for a stress-free trip.
Personalize your itinerary
Each package includes a professionally crafted itinerary you can tailor to your travel style. A dedicated travel expert will make sure every detail fits your needs perfectly.
Easily make changes
Need to update plans? No problem. Whether before your trip or mid-journey, we’re just seconds away to help with quick adjustments.
Enjoy seamless planning
With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.
Explore with confidence
From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.
Secure your spot
Confirm your package instantly and lock in the best rate with secure payment and guaranteed availability.
Get instant confirmation
Shortly after booking, you’ll receive your full itinerary, including schedules, locations, and everything you need for a stress-free trip.
Personalize your itinerary
Each package includes a professionally crafted itinerary you can tailor to your travel style. A dedicated travel expert will make sure every detail fits your needs perfectly.
Easily make changes
Need to update plans? No problem. Whether before your trip or mid-journey, we’re just seconds away to help with quick adjustments.
Enjoy seamless planning
With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.
Explore with confidence
From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.

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Your trip is protected, personalized, and priced right. No surprises, no stress.

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