10-Day Italy Self-Drive Road Trip With Itinerary from Rome to Florence, Perugia, and Naples and surrounding area

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Explore the best of Italy on a remarkable 10-day road trip! Combine exploration with relaxation on a self-drive tour featuring Rome, Florence, Pisa, Perugia, Caserta, Pompei, and Naples.

This perfectly planned road trip itinerary takes you through some of the best places to see in Italy. You will spend 4 nights in Rome, 2 nights in Florence, 1 night in Perugia, and 2 nights in Naples. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Italy. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have you covered.

Upon arriving in Rome, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Italy on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Italy. Trevi Fountain and Colosseum are just a couple of the bucket-list attractions that await your discovery.

As you hit the open road and drive through Rome, Florence, Pisa, Perugia, Caserta, Pompei, and Naples, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Italy. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Italy.

Throughout your road trip in Italy, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Italy.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodations, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in Italy fill up quickly, so book your spot early. Select a date and start planning your road trip in Italy today!

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Driver’s age is 30 - 65
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Day1

Day 1

  • Rome - Arrival day
  • More
  • Altare della Patria
  • More

Your road trip adventure in Italy begins as soon as you reach Rome and pick up your car. You’ll stay here for 3 nights and explore what to see in Rome, sample the local cuisine, and choose from a curated selection of the best hotels and places to stay in the city.

Rome is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out Altare Della Patria. Taking a stroll in the city center is a great alternative. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

When you're ready for some downtime, make your way to your chosen hotel. Check-in typically starts between 2 and 4 PM in Rome. Make yourself at home and unwind before heading out again.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Rome, it's often a good idea to reserve a table in advance.

Make sure to reserve a table at La Bottega Roma, an iconic dining spot in Rome. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Pasta In Corso, a popular restaurant in Rome. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of Trattoria Vecchia Roma, a hidden gem nestled in Rome. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

Continue your lively evening at La Botticella Of Poggi Giovanni, a perfect place for winding down or revving up the night, depending on which mood you’re in. Almalu Trastevere is another excellent bar that offers a great selection of drinks to suit any mood. If you prefer to go somewhere else, Bar Viminale Di Pepi Maurilio ensures a night out tailored to your taste.

Raise a toast to the start of your 10-day road trip in Italy!

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Day2

Day 2

  • Rome
  • More

Drive 11 km, 1 hour 11 min

  • Villa Borghese
  • Roman Forum
  • Colosseum
  • Circus Maximus
  • Orange Garden
  • More

Day 2 of your road trip across Italy promises a magnificent time exploring what to see in Rome. You have 2 nights left in Rome. Take the opportunity to experience more of the best attractions and activities in the city.

To truly experience Rome, make sure to drop by Villa Borghese. This top-rated park is a must-visit for anyone seeking a unique vacation experience. Another sight you shouldn’t miss is Roman Forum, one of the city’s best highlights.

Next, check out Colosseum, one of the most wondrous places to see in Rome. This archeological site is a favorite among locals and travelers alike. Enjoy some downtime and refreshments before continuing to your next stop, Circus Maximus. Wander around and soak in the picture-perfect atmosphere this archeological site offers. Then, head to Orange Garden, a top-rated park that adds another dimension to your day.

Don’t forget to check out all the popular tours and experiences you can add to your travel plans in Italy. You can explore and select activities under each day of your itinerary.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Rome. Enjoy a relaxing evening as you savor delicious local cuisine.

Begin your culinary exploration in Rome by securing a reservation at La Pergola. This renowned restaurant holds 3 Michelin star and offers an exceptional menu of mediterranean and contemporary cuisine. For another dining delight, visit Il Pagliaccio, celebrated for its delectable creative and innovative menu. This acclaimed 2-star Michelin-recipient consistently leaves guests satisfied, making it a must-visit during your holiday. Looking for a different experience? Discover Enoteca La Torre, a top local spot known for its tantalizing mediterranean and creative menu. With a 2-star Michelin recognition, it guarantees an exceptional dining adventure.

After enjoying a fulfilling meal, continue your evening at Sant' Eustachio Caffè, ideal for those looking to unwind with a drink in a comfortable setting. Alternatively, Yellowsquare Rome offers a welcoming atmosphere for easing into the nightlife. Similarly, Caffè Portofino provides an excellent environment for a relaxed and enjoyable evening.

Raise your glass and celebrate another amazing day of your road trip in Italy!

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Day3

Day 3

  • Rome
  • More

Drive 12 km, 1 hour 1 min

  • Basilica di Santa Maria Maggiore
  • Pantheon
  • Piazza Navona
  • Campo de' Fiori
  • Castel Sant'Angelo
  • More

On day 3 of your road trip, you will have an entire day to discover what to see in Rome. You’ll stay in Rome for 1 night.

Make a stop at Basilica Di Santa Maria Maggiore. This locally renowned church is a must-visit for travelers looking for a unique holiday experience. Make your way to Pantheon located in Rome for another exciting encounter.

Next, immerse yourself in the setting of Piazza Navona. Its romantic features will captivate you. After the public square, continue your tour of the city with a visit to Campo De' Fiori. Visitors usually appreciate the historic features of this public square. Next up is Castel Sant'angelo, a highly recommended castle.

Don’t forget to check out all the popular tours and experiences you can add to your travel plans in Italy. You can explore and select activities under each day of your itinerary.

Indulge in a memorable dining experience at one of Rome's most popular restaurants, and connect with friendly locals for a true cultural experience.

Enjoy a lovely meal at Hotel de Russie, a top-rated place to have dinner tonight. Alternatively, if your taste buds call for something different, La Taverna Italiana is another top choice with a popular menu. You could also check for a table at The Parrot Bar. As an establishment that consistently gains high praises from customers, it’s an ideal choice in Rome tonight.

Unwind after your meal by stepping into The Apartment Bar Roma. This venue is celebrated for its extensive drink selections and cozy vibes. Alternatively, Hotel Hassler Roma offers a dynamic and energetic atmosphere for a glass or two.

Raise your glass to another unforgettable day in Italy!

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Day4

Day 4

  • Rome
  • Florence
  • More

Drive 277 km, 3 hours 31 min

  • Trevi Fountain
  • Piazza di Spagna
  • Spanish Steps
  • piazza del Popolo
  • Auditorium Parco della Musica
  • More

Your itinerary for day 4 of your road trip in Italy includes 1 stop and features some of the highlights of Rome. At the end of the day, enjoy the comforts of a top-rated hotel in Florence, where you'll spend 2 nights.

Check out the world-famous monument, Trevi Fountain. Afterward, continue to Piazza Di Spagna, a public square every traveler should visit. As you explore Rome’s charming streets, take in the lively atmosphere and get to know the character of the city.

Next, make your way to Spanish Steps. This widely recognized public square is an essential stop. Following that, head to Piazza Del Popolo, another must-visit site that will enhance your experience. Don’t forget to stop by Auditorium Parco Della Musica, a notable concert hall in the city.

After soaking up all the sights on today's itinerary, you'll be ready to head to your accommodation in Florence. Florence offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Florence, it's often a good idea to reserve a table in advance.

Experience a symphony of flavors at Enoteca Pinchiorri in Florence by securing a reservation in advance. Renowned for its 3-star Michelin distinction, Enoteca Pinchiorri delights its guests with its exceptional variety of meals showcasing delicious italian contemporary cuisine. For a palate-pleasing alternative, make sure to dine at Santa Elisabetta, acclaimed for its delectable creative and mediterranean specialties. This local 2-star Michelin establishment consistently satisfies guests, ensuring an unforgettable holiday experience. Want to go on another culinary journey? Delight your senses at Gucci Osteria da Massimo Bottura, a top-rated restaurant known for its outstanding menu. Known as a top-rated 1-star Michelin establishment, it's a top choice for italian contemporary and international cuisine in the city.

Cap off your dinner by heading to Manifattura, ideal for a leisurely evening with a drink in hand. Se·sto On Arno Rooftop Bar is another bar that offers an enjoyable setting. Similarly, Il Vinile is also a popular place to go on a night out, perfect for relaxing and socializing.

Say good night to Florence and look forward to another great day of your road trip in Italy!

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Day5

Day 5

  • Florence
  • More

Drive 5 km, 1 hour 21 min

  • David
  • Galleria dell'Accademia
  • Cathedral of Santa Maria del Fiore
  • Ponte Vecchio
  • piazzale Michelangelo
  • More

Day 5 of your road trip will take you to the best attractions Florence has to offer. Cherish the 1 night you have left in the city and use the provided itinerary to discover what to see in Florence.

Florence is brimming with adventures.

Whatever your travel style is, David is an essential stop in Florence. This captivating statue provides an insightful glimpse into the city's identity. Next, discover Galleria Dell'accademia, a detailed art gallery, promising a delightful encounter.

Continue your sightseeing with a visit to Cathedral Of Santa Maria Del Fiore, a top-rated church. When you’re done, don’t forget to make a stop at the globally renowned Ponte Vecchio. Round off your day at Piazzale Michelangelo, another gem in Florence with history-steeped features to discover.

Don’t forget to check out all the popular tours and experiences you can add to your travel plans in Italy. You can explore and select activities under each day of your itinerary.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Florence, it's often a good idea to reserve a table in advance.

Make sure to reserve a table at Ditta Artigianale, an iconic dining spot in Florence. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Trattoria Da Burde, a popular restaurant in Florence. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of Casa Toscana, a hidden gem nestled in Florence. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

Keep the excitement of the evening going by visiting a bar or two. Bar 50 Rosso is an excellent place to start. You could also check out Bitter Bar, offering a different kind of charm. A last recommendation for the day is Archea Brewery. This bar promises an enjoyable experience with tasty drinks and a vibrant setting.

Relax and look forward to more memorable moments to come!

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Day6

Day 6

  • Florence
  • Pisa
  • Perugia
  • More

Drive 336 km, 4 hours 24 min

  • piazza della Signoria
  • Central Market
  • Leaning Tower of Pisa
  • Piazza del Duomo, Pisa
  • More

Experience an unparalleled adventure on day 6 of your road trip in Italy. This exciting part of your journey invites you to discover the renowned landmarks in 2 places, which are Florence and Pisa. At the end of the day, you will retreat to the hotel of your choice in Perugia, where will spend 1 night.

Whatever your travel style is, Piazza Della Signoria is an essential stop in Florence. This widely recognized public square provides an insightful glimpse into the city's identity. Next, discover Central Market, a photogenic food market, promising a delightful encounter.

Set your GPS to Pisa and hit the road. Expect a journey of approximately 1 hour 18 min without stops. Soak in the beautiful landscapes as you drive and look forward to exploring your next destination. Pisa beckons with new experiences!

When you're ready for some sights, head to Leaning Tower Of Pisa, a world-famous monument in Pisa. Explore its breathtaking features at your own pace before you continue your journey to your next attraction, Piazza Del Duomo, Pisa. This timeless public square is a top recommendation in the area.

At the end of the day, you will drive to Perugia, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Perugia. Enjoy a relaxing evening as you savor delicious local cuisine.

Make sure to reserve a table at Ristorante Settimo Sigillo, an iconic dining spot in Perugia. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Caffè Baglioni, a popular restaurant in Perugia. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of Bar Pellas, a hidden gem nestled in Perugia. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

Cap off your culinary experience with a visit to some of the most celebrated bars in the area. For instance, Tommi Bar stands out as an excellent choice for a post-dinner cocktail. Alternatively, Valentina offers an ideal atmosphere to enjoy the pleasures of the night. Caffe Dal Perugino is also a great option that provides a perfect setting for a relaxing evening.

Take some time to reflect on your day and savor another beautiful night in Italy.

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Day7

Day 7

  • Perugia
  • Caserta
  • Pompei
  • Naples
  • More

Drive 424 km, 5 hours 1 min

  • Palace of Caserta
  • Archaeological Park of Pompeii
  • Macellum - Excavations
  • More

On day 7 of your road trip in Italy, your travel plans include 2 stops at the most scenic, wondrous, and interesting places in the region. Caserta and Pompei are on today's agenda. In the evening, you’ll end up in Naples, where you will stay for 2 nights.

Once you're ready to continue your road trip, it's time to buckle up and drive, eagerly anticipating your arrival in Caserta. This drive usually takes around 3 hours 38 min, without any stops or traffic disruptions.

One of our top recommendations for your sightseeing is Palace Of Caserta. Spend some time admiring the visually striking features of the palace before you continue to your next stop.

Continue your road trip and head to your next destination, Pompei. This car ride takes around 41 min.

Set out on a self-guided sightseeing tour at Archaeological Park Of Pompeii and explore the standout features. Next, make your way to Macellum - Excavations, another highlight in Pompei.

When you’re done exploring for the day, you’ll drive to your hotel in Naples. Check in and relax before you head out to tour the city.

Naples is a place where the culinary landscape is as diverse as its attractions. So before the day ends, treat your palate to a taste of local cuisine at one of the best restaurants in Naples.

Get ready for an unforgettable culinary journey in Naples by reserving a table at Veritas. Renowned as a 1-star Michelin restaurant, it offers an exceptional campanian and contemporary menu. For a different taste experience, head to Il Comandante, recognized for its delicious creative and mediterranean dishes. This 1-star Michelin restaurant consistently impresses guests, ensuring a memorable addition to your holiday. Looking for another option? Make sure to visit ARIA, a local favorite known for its delightful contemporary and modern cuisine in Naples. Nestled in the heart of the city, this restaurant with 1 Michelin star is an ideal choice for contemporary and modern foodies seeking culinary excellence.

Keep the evening going at Happening Cocktail Bar, a great choice for enjoying the after-dinner hours with a drink. You could also go to Shanti Art Musik Bar, which offers a similarly pleasant setting and great drinks. Another option is Gran Caffè Gambrinus, which provides an inviting environment for unwinding after a busy day out.

Relax and recharge in preparation for another adventurous day in Italy!

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Day8

Day 8

  • Naples
  • More

Drive 9 km, 1 hour 27 min

  • Ovo Castle
  • piazza del Plebiscito
  • San Carlo Theatre
  • Naples National Archaeological Museum
  • Cappella Sansevero
  • More

Day 8 offers an itinerary packed with the best things to see in Rome. You’ll stay in Naples for 1 night more, offering you enough time to explore at a relaxed pace.

Make time for Ovo Castle, a locally renowned castle that is worthwhile a visit in the city. Nearby, you’ll find Piazza Del Plebiscito, enchanting visitors with its history-steeped appeal. Continue your exploration at San Carlo Theatre. This opera house is one of the city’s most locally appreciated spots.

Enjoy the freedom of exploring Naples at your own pace and find hidden gems along the way. If you want to see more picture-perfect spots, make sure to visit Naples National Archaeological Museum. After exploring the museum, head to the notable Cappella Sansevero.

Don’t forget to check out all the popular tours and experiences you can add to your travel plans in Italy. You can explore and select activities under each day of your itinerary.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Naples. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Have a fantastic dining experience at Antica Pizzeria Di Matteo, a highly recommended choice for tonight's dinner. If you're looking to mix things up, Mercure Napoli Centro Angioino offers an enticing alternative with its varied menu. Additionally, La Lazzara Trattoria e Pizzeria is worth considering. Renowned for satisfying diners, it’s an ideal option for tonight in Naples.

Keep the evening going at Archivio Storico - Cocktail Bar & Wonderfood, a great choice for enjoying the after-dinner hours with a drink. You could also go to Archeobar, which offers a similarly pleasant setting and great drinks. Another option is Babette Pub, which provides an inviting environment for unwinding after a busy day out.

Get a good night's sleep and look forward to another great day on the road in Italy!

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Day9

Day 9

  • Naples
  • Vatican City
  • Rome
  • More

Drive 241 km, 3 hours 29 min

  • St Peter's Basilica
  • Sistine Chapel
  • Saint Peter's Square
  • Vatican Museums
  • More

On day 9 of your exciting self-drive vacation in Italy, you’ll soak in the magnificence of 1 destination, including Vatican City. When you’re not sightseeing, take time to relax at your chosen hotel in Rome, where you’ll be staying for 1 night.

Embrace the thrill of the open road as you wave goodbye to Naples and set your GPS to Vatican City, Vatican City. While on the road, immerse yourself in your favorite road trip tunes or sample the sounds from a local radio station. This car ride usually takes around 2 hours 40 min. Upon reaching Vatican City, unwind, observe, and explore. The best things to do, see, and eat are waiting for you.

Savor the day by heading to St. Peter's Basilica, an iconic major basilica that draws visitors from near and far.

Next, explore Saint Peter's Square, yet another locally renowned place to see in the area. After the square, make time to go to Vatican Museums.

After soaking up all the sights on today's itinerary, you'll be ready to head to your accommodation in Rome. Rome offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Rome. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Enjoy a lovely meal at Sofitel Roma Villa Borghese, a top-rated place to have dinner tonight. Alternatively, if your taste buds call for something different, Centro is another top choice with a popular menu. You could also check for a table at Ristorante Tema. As an establishment that consistently gains high praises from customers, it’s an ideal choice in Rome tonight.

Savor another day of unforgettable experiences in Italy!

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Day10

Day 10

  • Rome - Departure day
  • More
  • largo di Torre Argentina
  • More

Day 10 of your road trip in Italy is your departure day. This is your chance to catch a last glimpse of Rome before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

If you're up for some more sightseeing, we recommend visiting Largo Di Torre Argentina, an eye-catching archeological site before you head out.

For a last-minute shopping spree in Rome, Trastevere is nearby. Enjoy a variety of retail stores, dining options, and essential services in one convenient location. Browse through boutiques to find unique and stylish fashion pieces to take home.

Before you conclude your road trip in Italy, drop by another restaurant for a last chance at a memorable dining experience in Rome.

Treat yourself to a delightful dinner at Ristorante Va. Do. , highly recommended for tonight's dining. Or, if you're feeling adventurous, why not try Giulia Restaurant? It's another excellent option with a diverse menu.

You’ll then say farewell to Rome. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Italy!

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Each package includes a professionally crafted itinerary you can tailor to your travel style. A dedicated travel expert will make sure every detail fits your needs perfectly.
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Need to update plans? No problem. Whether before your trip or mid-journey, we’re just seconds away to help with quick adjustments.
Enjoy seamless planning
With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.
Explore with confidence
From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.
Secure your spot
Confirm your package instantly and lock in the best rate with secure payment and guaranteed availability.
Get instant confirmation
Shortly after booking, you’ll receive your full itinerary, including schedules, locations, and everything you need for a stress-free trip.
Personalize your itinerary
Each package includes a professionally crafted itinerary you can tailor to your travel style. A dedicated travel expert will make sure every detail fits your needs perfectly.
Easily make changes
Need to update plans? No problem. Whether before your trip or mid-journey, we’re just seconds away to help with quick adjustments.
Enjoy seamless planning
With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.
Explore with confidence
From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.

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Your trip is protected, personalized, and priced right. No surprises, no stress.

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