10-Day Italy Self-Drive Road Trip With Itinerary from Rome to Florence, Perugia, and Naples and surrounding area

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Escape the ordinary with this exciting 10-day road trip through Italy. Explore the diverse landscapes, lively cities, and beyond. Pack your bags, hit the road, and prepare for an unforgettable journey!

This perfectly planned road trip itinerary in Italy takes you through some of the best places to see in the country. You will spend 4 nights in Rome, 2 nights in Florence, 1 night in Perugia, and 2 nights in Naples. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Italy. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have got you covered.

Upon arriving in Rome, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Italy on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Italy. Trevi Fountain and Colosseum are just a couple of the bucket-list attractions that await your discovery.

As you hit the open road and drive through Rome, Florence, Pisa, Perugia, Caserta, Pompei, and Naples, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Italy. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Italy.

Throughout your road trip in Italy, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Italy.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodation, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in Italy fill up quickly, so book your spot early. Select a date and start planning your road trip in Italy today!

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Day 1

Day 1 – Rome - arrival day

  • Rome - Arrival day
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  • Altare della Patria
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Welcome to Rome, the perfect starting point for your road trip in Italy! Pick up your rental car and let the adventure begin. You will spend 3 nights immersing yourself in Rome's charm before embarking on the next leg of your journey.

Rome is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out Altare Della Patria or taking a stroll in the city center. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

As afternoon approaches, head to your chosen hotel in Rome. Check-in typically starts around 2 to 4 PM at hotels in Italy. We recommend staying at a hotel in a central location for easy access to the best attractions, restaurants, and bars in the city.

As dinnertime approaches, it's time to head out for a bite to eat in Rome. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.

Treat yourself to a wonderful meal at La Bottega Roma, a top-rated dining spot in Rome. If you're in the mood for something new, try Pasta In Corso, another premier location with a delectable menu. You might also want to book a table at Trattoria Vecchia Roma. Known for its consistently satisfied patrons, it’s a perfect choice to elevate your evening in Rome.

After your delicious meal, get a taste of the vibrant nightlife with a visit to La Botticella Of Poggi Giovanni, known for its inviting atmosphere. Almalu Trastevere is another great option if you’re looking for a place to get the night started. Similarly, Bar Viminale Di Pepi Maurilio provides a great setting to enjoy the night away.

Raise a toast to the start of your 10-day road trip in Italy!

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Day 2

Day 2 – Rome

  • Rome
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Drive 11 km, 1 hour 11 min

  • Villa Borghese
  • Roman Forum
  • Colosseum
  • Circus Maximus
  • Orange Garden
  • Trevi Fountain
  • More

Day 2 of your road trip will take you to the best attractions Rome has to offer. Cherish the 2 nights you have left in Rome by discovering the best things there are to see and do in the city.

Today’s well-planned self-sightseeing route offers several a romantic, an idyllic, a breathtaking, a photogenic, a history-steeped, a remarkable, a grand, and an UNESCO world heritage-designated. Whether you decide to explore Rome on foot, use public transport, or join a guided tour, there are a few attractions you don’t want to miss. Villa Borghese is the first of them. Spend some time admiring this serene park before continuing your journey. Roman Forum is your next stop. This iconic archeological site is one of the best-rated sights in Rome.

Consider grabbing some lunch or a light snack to keep your energy going. Beyond the above-mentioned attractions, today is also the perfect time to visit Colosseum. This respected archeological site is a sight to behold. To round off your sightseeing experience, visit Circus Maximus and Orange Garden.

Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.

Indulge in a memorable dining experience at one of Rome's most popular restaurants, and connect with friendly locals for an authentic adventure.

Experience a symphony of flavors at La Pergola in Rome by securing a reservation in advance. Renowned for its 3-star Michelin distinction, La Pergola delights its guests with its exceptional variety of meals showcasing delicious mediterranean and contemporary cuisine. For a palate-pleasing alternative, make sure to dine at Il Pagliaccio, acclaimed for its delectable creative and innovative specialties. This local 2-star Michelin establishment consistently satisfies guests, ensuring an unforgettable holiday experience. Want to go on another culinary journey? Delight your senses at Enoteca La Torre, a top-rated restaurant known for its outstanding menu. Known as a top-rated 2-star Michelin establishment, it's a top choice for mediterranean and creative cuisine in the city.

Keep the evening going at Sant' Eustachio Caffè, a great choice for enjoying the after-dinner hours with a drink. You could also go to Yellowsquare Rome, which offers a similarly pleasant setting and great drinks. Another option is Caffè Portofino, which provides an inviting environment for unwinding after a busy day out.

Head back to your accommodation in Rome and get some rest in preparation for another magical day of your road trip in Italy!

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Day 3

Day 3 – Rome

  • Rome
  • More

Drive 12 km, 1 hour 1 min

  • Basilica di Santa Maria Maggiore
  • Pantheon
  • Piazza Navona
  • Campo de' Fiori
  • Castel Sant'Angelo
  • Trevi Fountain
  • More

On day 3 of your road trip, you will have an entire day to explore Rome. You’ll stay in Rome for 1 night and discover all the best things to see and do in the area.

Today’s itinerary in Rome covers several incredible sights, including a church, a monument, a public square, a castle and much more! Start your adventure at Basilica Di Santa Maria Maggiore. This popular church is a place that is appreciated by travelers and locals alike. Next, immerse yourself in the culturally significant wonders of Pantheon, a must-see monument in the city.

Consider stopping for a small bite to eat or a drink at a local eatery to keep your energy going. When you’re ready, continue your discovery with a visit to Piazza Navona. This globally renowned public square offers an enriching experience. For a change of pace, head to Campo De' Fiori, where you can take in its historic features. Conclude your self-guided sightseeing tour with a visit to Castel Sant'angelo. This visually striking castle offers a fulfilling end to a perfect day.

Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.

As you explore more of Rome, you'll discover that its culinary landscape is as diverse as its attractions. Whether you're craving traditional dishes bursting with local flavors or innovative creations that push the boundaries of taste, you're sure to find a dining experience that satisfies your cravings.

Make sure to book a table at Hotel de Russie, a popular restaurant in Rome. This acclaimed restaurant and its mouthwatering dishes have earned the admiration of countless food lovers. Alternatively, experience a taste of Rome at La Taverna Italiana, a popular local restaurant. With a menu designed to impress, it promises a journey of flavors that will leave you captivated. Another top-rated restaurant to try is The Parrot Bar. As a dining spot that gains high praise from guests, it’s an ideal choice to enhance your time to Rome tonight.

Continue the enjoyment post-dinner at The Apartment Bar Roma, a cherished local gathering spot renowned for its welcoming atmosphere. Similarly, Hotel Hassler Roma offers a vibrant space for indulging in well-crafted drinks and engaging conversation.

Take some time to reflect on your day and savor another beautiful night in Italy.

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Day 4

Day 4 – Rome and Florence

  • Rome
  • Florence
  • More

Drive 277 km, 3 hours 31 min

  • Trevi Fountain
  • Piazza di Spagna
  • Spanish Steps
  • piazza del Popolo
  • More

On day 4 of your exciting self-drive vacation in Italy, you’ll soak in the magnificence of 1 destination, Rome. When you’re not sightseeing, take time to relax at your selected hotel in Florence, where you’ll be staying for 2 nights.

Bring your curiosity for today’s adventure around Rome. Some of the city’s most loved attractions await. Piazza Di Spagna is the perfect place to start. This public square is one of the most world-famous places to visit in Rome. Next, head to Spanish Steps, an extraordinary public square, known for its visually striking features.

In between the sights, don’t hesitate to take small detours to explore local stores and eateries. When you’re ready to continue your adventure, head to Piazza Del Popolo. This detailed public square offers a unique experience that is highly recommended. Meanwhile, Auditorium Parco Della Musica adds its own distinct charm to your journey.

After soaking up all the sights of today's itinerary, you'll be ready to hit the road in the direction of your accommodation in Florence. Florence offers plenty of top-rated hotels and other places to stay on any travel budget. Take some time to relax before you head out to explore.

Indulge in a memorable dining experience at one of Florence's most popular restaurants, and connect with friendly locals for an authentic adventure.

Experience a harmony of flavors at Enoteca Pinchiorri in Florence by securing a reservation in advance. Known for its 3-star Michelin status, Enoteca Pinchiorri offers a delightful variety of dishes highlighting its delicious italian contemporary menu. If you're seeking an alternative culinary experience, be sure to explore Santa Elisabetta, a highly recommended restaurant known for its enticing creative and mediterranean cuisine. This popular 2-star Michelin-awarded venue consistently exceeds expectations, ensuring a memorable holiday experience. Ready for another culinary adventure? Indulge your senses at Gucci Osteria da Massimo Bottura, a highly acclaimed restaurant celebrated for its exceptional italian contemporary and international menu.

After your delicious meal, get a taste of the vibrant nightlife with a visit to Manifattura, known for its inviting atmosphere. Se·sto On Arno Rooftop Bar is another great option if you’re looking for a place to get the night started. Similarly, Il Vinile provides a great setting to enjoy the night away.

As the day draws to a close, take a moment to unwind and prepare for the next exciting chapter of your road trip in in Italy.

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Day 5

Day 5 – Florence

  • Florence
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Drive 5 km, 1 hour 21 min

  • David
  • Galleria dell'Accademia
  • Cathedral of Santa Maria del Fiore
  • Ponte Vecchio
  • piazzale Michelangelo
  • More

Day 5 offers a multitude of experiences. You will stay in Florence for 1 night more, offering you enough time to explore at a relaxed pace.

Prepare for a day full of a picture-perfect, a historic, a detailed, a romantic, a stunning, a culturally significant, a culturally significant, and an UNESCO world heritage-listed. When you’re ready, kick off your sightseeing adventure at David. This well-known statue is a must-visit for anyone seeking a unique vacation experience. Another sight you shouldn’t miss is Galleria Dell'accademia, one of the city’s most promising highlights.

Next, check out Cathedral Of Santa Maria Del Fiore, one of the most astonishing places to see in Florence. This church is a favorite among locals and travelers alike. Enjoy some downtime and refreshments before continuing to your next stop, Ponte Vecchio. Wander around and soak in the visually striking atmosphere this historical landmark offers. Finally, take the path to the extraordinary Piazzale Michelangelo, the last of our attraction recommendations for today.

Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.

After a day of adventure, treat yourself to an exquisite dinner at one of Florence's best restaurants.

Dine in style at Ditta Artigianale, a top recommendation for dinner tonight. Or, for a change of pace, Trattoria Da Burde boasts a menu that's sure to impress. Also, be sure to check out Casa Toscana. Known as a local hotspot, it’s a great choice for tonight in Florence.

Let the evening flow smoothly from dinner to drinks at Bar 50 Rosso, a top-rated bar in the area. For other recommendations, Bitter Bar provides a perfect setting for rounding out your night with style and great drinks. Likewise, Archea Brewery offers a memorable night with diverse drink options and excellent service.

Get a good night's sleep and look forward to another great day on the road in Italy!

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Day 6

Day 6 – Florence, Pisa, and Perugia

  • Florence
  • Pisa
  • Perugia
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Drive 336 km, 4 hours 24 min

  • piazza della Signoria
  • Leaning Tower of Pisa
  • Piazza del Duomo, Pisa
  • Ponte Vecchio
  • More

Dive into day 6 of your remarkable road trip in Italy. Today you will explore Florence and Pisa, where you will have the opportunity to experience all the top things to see and do. At the end of the day, you’ll unwind at one of the finest accommodations in Perugia. You’ll stay here for 1 night.

Florence is brimming with adventures. Today’s wonderful stops include a public square and a food market. Begin your sightseeing adventure at the famous Piazza Della Signoria. Just a short distance away is Central Market, an eye-catching food market that draws visitors from far and near.

Fasten your seatbelt and make your way to your next stop. Pisa, home to many well-known sights in the region, is a lovely destination on today’s itinerary. Keep in mind that your travel time from Florence to Pisa may take around 1 hour 18 min without traffic disruptions. Upon arrival in Pisa, we highly recommend checking out some of the top attractions.

Savor the rest of your day by heading to Leaning Tower Of Pisa, a wondrous monument that draws visitors from near and far. When you're done, continue on to Piazza Del Duomo, Pisa, where you can soak in the UNESCO world heritage-listed surroundings.

When you’re done exploring for the day, you’ll drive to your hotel in Perugia. Check in and spend some time relaxing before you head out to tour the city.

After a day of adventure, treat yourself to an exquisite dinner at one of Perugia's best restaurants.

Treat yourself to a delightful dinner at Ristorante Settimo Sigillo, highly recommended for tonight's dining. Or, if you're feeling adventurous, why not try Caffè Baglioni? It's another excellent option with a diverse menu. Consider reserving a table at Bar Pellas as well. Known for its consistent customer satisfaction, it’s an ideal pick for tonight in Perugia.

To truly maximize your evening out, consider visiting Tommi Bar after dinner. This bar is known for offering some of the best drinks and vibes in the city. Alternatively, head to Valentina, another bar with an inviting ambiance. Similarly, Caffe Dal Perugino also offers a great atmosphere, ensuring a night filled with enjoyment and relaxation.

As the sun sets on another day of adventure, rest up and recharge for the next leg of your road trip in Italy.

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Day 7

Day 7 – Perugia, Caserta, Pompei, and Naples

  • Perugia
  • Caserta
  • Pompei
  • Naples
  • More

Drive 424 km, 5 hours 1 min

  • Palace of Caserta
  • Archaeological Park of Pompeii
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Experience an unparalleled adventure on day 7 of your road trip in Italy. This exciting part of your journey invites you to discover the renowned landmarks in 2 vibrant destinations - Caserta and Pompei. After a day filled with exploration and new experiences, you will retreat to the hotel of your choice in Naples. You will spend 2 nights here for some well-deserved relaxation.

When you’re ready to jump back into the car and say goodbye to Perugia, you’ll hit the road in the direction of Caserta. This drive usually takes around 3 hours 38 min. When you arrive, enjoy some sightseeing.

Begin your journey at Palace Of Caserta and explore the visually striking features.

Set your GPS to Pompei and hit the road. Expect a journey of approximately 41 min without stops. Soak in the beautiful landscapes as you drive and look forward to exploring your next destination. Pompei beckons with new experiences!

Head to Archaeological Park Of Pompeii, a captivating archeological site in Pompei. Explore its stunning features at your own pace before you continue your journey to your next sight, Macellum - Excavations. This beloved archeological site is a top recommendation in the area.

At the end of the day, you will drive to Naples, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Naples. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Treat yourself to an extraordinary dining experience at Veritas, a 1-star Michelin restaurant offering an incredible campanian and contemporary menu. Alternatively, if your taste buds call for something different, Il Comandante is one of the best restaurants for creative and mediterranean cuisine in Naples. This 1-star Michelin-awardee earns consistently high praises from guests. We also recommend checking out the menu at ARIA. As a top-rated establishment with 1 Michelin star, it is an ideal choice for contemporary and modern cuisine in the city.

After enjoying a delightful dinner, why not delve into the vibrant local bar scene? You might want to spend the evening at Happening Cocktail Bar, a well-loved spot among locals and tourists. Or, head to Shanti Art Musik Bar. This bar boasts a welcoming environment that is perfect for winding down. You could also continue your night at Gran Caffè Gambrinus, another top-rated place in the area.

Take some time to reflect on your day and savor another beautiful night in Italy.

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Day 8

Day 8 – Naples

  • Naples
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Drive 9 km, 1 hour 27 min

  • Ovo Castle
  • piazza del Plebiscito
  • San Carlo Theatre
  • Naples National Archaeological Museum
  • Cappella Sansevero
  • More

Day 8 of your road trip across Italy promises a magnificent time exploring Naples. You have 1 night left in Naples. Take the opportunity to experience more of the best attractions and activities in the city.

Get ready to discover some of the most iconic wonders in Naples, including a castle, a public square, an opera house, a museum and much more! Start your day at Ovo Castle. This awe-inspiring castle is an interesting place to see in Naples. Then, wander over to Piazza Del Plebiscito. If visually striking sites excite you, this public square will be right up your alley. Nearby, you’ll also find San Carlo Theatre. This historic opera house is a favorite among visitors.

Naples offers plenty to explore, ensuring every moment of your visit is filled with excitement and discovery. If you're up for more, Naples National Archaeological Museum is a popular spot in the city that will captivate you with its unique charm. When you’re done at the museum, don’t forget to check out the instagrammable Cappella Sansevero. Take a moment to appreciate the fascinating details of this captivating museum in Naples.

Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Naples. Enjoy a relaxing evening as you savor delicious local cuisine and reflect on the day's adventures.

Enjoy a delicious meal at Antica Pizzeria Di Matteo, a top-rated dining destination in Naples. If you're in the mood to try something new, consider Mercure Napoli Centro Angioino, another top spot with a mouthwatering menu. You might also want to secure a reservation at La Lazzara Trattoria e Pizzeria. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Naples this evening.

After enjoying a delightful dinner, why not delve into the vibrant local bar scene? You might want to spend the evening at Archivio Storico - Cocktail Bar & Wonderfood, a well-loved spot among locals and tourists. Or, head to Archeobar. This bar boasts a welcoming environment that is perfect for winding down. You could also continue your night at Babette Pub, another top-rated place in the area.

Say good night to Naples and look forward to another great day of your road trip in Italy!

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Day 9

Day 9 – Naples, Vatican City, and Rome

  • Naples
  • Rome
  • More

Drive 241 km, 3 hours 29 min

  • St Peter's Basilica
  • Sistine Chapel
  • Saint Peter's Square
  • Vatican Museums
  • piazza del Plebiscito
  • More

Embark on another extraordinary experience on day 9 of your road trip in Italy. Today, you will make 1 stop and experience some of the highlights of Vatican City. At the end of the day, you will enjoy the comforts of a top-rated hotel in Rome, which will be your home away from home for 1 night.

Today's adventure in Vatican City promises more breathtaking discoveries and enriching experiences!

Continue your road trip and head to your next destination, Vatican City, Vatican City. This car ride takes around 2 hours 40 min.

One of our top recommendations for your sightseeing is St. Peter's Basilica. Then, head to Sistine Chapel. This spectacular chapel is a traveler-favorite in the city. Not far away, you’ll also find Saint Peter's Square. Feed your curiosity by learning something new about the square. Next, continue your journey to Vatican Museums, a timeless art museum.

After soaking up all the sights of today's itinerary, you'll be ready to hit the road in the direction of your accommodation in Rome. Rome offers plenty of top-rated hotels and other places to stay on any travel budget. Take some time to relax before you head out to explore.

As dinnertime approaches, it's time to head out for a bite to eat in Rome. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.

Treat yourself to a delicious dinner at Sofitel Roma Villa Borghese, an excellent option for tonight's dining. Looking for something different? Centro offers a tantalizing alternative with its diverse menu. And don’t miss Ristorante Tema. With its reputation for pleasing customers, it’s a fantastic choice for tonight in Rome.

Savor another day of unforgettable experiences in Italy!

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Day 10

Day 10 – Rome - departure day

  • Rome - Departure day
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  • largo di Torre Argentina
  • Trevi Fountain
  • More

Day 10 of your road trip in Italy is your departure day. This is your chance to catch a last glimpse of Rome before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

Make the most of your final day in Italy by visiting Rome’s iconic markets and shopping establishments. Secure the perfect souvenirs for your family and friends back home or buy yourself a remembrance of your amazing experience in Italy.

Start your day at Largo Di Torre Argentina. This photogenic archeological site is a well-known place to see in Rome.

Before you conclude your road trip in Italy, drop by another restaurant for a last chance at a memorable dining experience in Rome.

Treat yourself to a delicious dinner at Ristorante Va. Do. , an excellent option for tonight's dining. Looking for something different? Giulia Restaurant offers a tantalizing alternative with its diverse menu. And don’t miss L'Archeologia.

You’ll then say farewell to Rome. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Italy!

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