10-Day Italy Self-Drive Road Trip With Itinerary from Venice to Florence, Lucca, San Gimignano, and Rome

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Explore the best of Italy on a remarkable 10-day road trip! Combine exploration with relaxation on a self-drive tour featuring Venice, Murano, Florence, Pisa, Lucca, Riomaggiore, Manarola, Corniglia, Levanto, Siena, San Gimignano, Rome, and Santa Maria degli Angeli.

This perfectly planned road trip itinerary takes you through some of the best places to see in Italy. You will spend 3 nights in Venice, 1 night in Florence, 2 nights in Lucca, 1 night in San Gimignano, and 2 nights in Rome. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Italy. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have you covered.

Upon arriving in Venice, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Italy on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Italy. Trevi Fountain and Colosseum are just a couple of the bucket-list attractions that await your discovery.

As you hit the open road and drive through Venice, Murano, Florence, Pisa, Lucca, Riomaggiore, Manarola, Corniglia, Levanto, Siena, San Gimignano, Rome, and Santa Maria degli Angeli, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Italy. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Italy.

Throughout your road trip in Italy, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Italy.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodations, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in Italy fill up quickly, so book your spot early. Select a date and start planning your road trip in Italy today!

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Driver’s age is 30 - 65
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Day1

Day 1

  • Venice - Arrival day
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  • Rialto Bridge
  • More

Your road trip adventure in Italy begins as soon as you reach Venice and pick up your car. You’ll stay here for 2 nights and explore what to see in Venice, sample the local cuisine, and choose from a curated selection of the best hotels and places to stay in the city.

Venice is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out Rialto Bridge. Taking a stroll in the city center is a great alternative. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

When you're ready for some downtime, make your way to your chosen hotel. Check-in typically starts between 2 and 4 PM in Venice. Make yourself at home and unwind before heading out again.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Venice, it's often a good idea to reserve a table in advance.

Treat yourself to a delightful dinner at Bauer Hotel, highly recommended for tonight's dining. Or, if you're feeling adventurous, why not try L'Osteria Le Guglie? It's another excellent option with a diverse menu. Consider reserving a table at Corner Pub as well. Known for its consistent customer satisfaction, it’s an ideal pick for tonight in Venice.

After enjoying a delightful dinner, why not delve into the vibrant local bar scene? You might want to spend the evening at Al Parlamento, a well-loved spot among locals and tourists. Or, head to The Caffe Rosso. This bar boasts a welcoming environment that is perfect for winding down. You could also continue your night at Adagio, another top-rated place in the area.

Raise a toast to the start of your 10-day road trip in Italy!

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Day2

Day 2

  • Venice
  • More

Drive 14 km, 34 min

  • Piazza San Marco
  • St Mark's Campanile
  • St Mark's Basilica
  • Doge's Palace
  • Bridge of Sighs
  • Murano
  • More

On day 2 of your road trip, you’ll start and end your day in Venice, where you have 1 night left to stay.

Piazza San Marco is must-visit public square and a great option for a daytime tour of the area. Continue your journey to St Mark's Campanile, a curiosity-inducing monument, located just a leisurely stroll away. Next, head to St Mark's Basilica, a majestic church, also available for your discovery today.

Each stop on today’s itinerary promises to leave you with lasting memories and a deeper appreciation for Venice. When you're ready, let your sightseeing route take you to the captivating Doge's Palace. If you’re looking for more, Bridge Of Sighs is also a locally renowned attraction that is worthwhile a visit. Lastly, don’t miss Murano, a place of romantic interest in the city.

When you’re done exploring for the day, you’ll return to Venice and your accommodation.

Venice is a place where the culinary landscape is as diverse as its attractions. So before the day ends, treat your palate to a taste of local cuisine at one of the best restaurants in Venice.

Don’t miss out on dining at Generator Venice, a top-rated dining destination in Venice. If you're in the mood to try something new, consider Nevodi, another top spot with a mouthwatering menu. You might also want to secure a reservation at Ristorante La Piazza. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Venice this evening.

Round off your dining experience by visiting Il Mercante, a prime location for a drink. Alternatively, explore the distinctive characteristics of The Irish Pub Venezia, a bar catering to every mood and preference. Ai Stagneri likewise offers a unique atmosphere, perfect for a memorable night out.

Raise your glass to another unforgettable day in Italy!

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Day3

Day 3

  • Venice
  • Florence
  • More

Drive 263 km, 3 hours 20 min

  • Ponte Vecchio
  • Uffizi Gallery
  • Basilica of Santa Croce in Florence
  • Hercules and Cacus
  • piazza della Signoria
  • More

On day 3 of your exciting self-drive vacation in Italy, you’ll soak in the magnificence of 1 destination, including Florence. When you’re not sightseeing, take time to relax at your chosen hotel in Florence, where you’ll be staying for 1 night.

Ponte Vecchio leaves a lasting impression. This historical landmark is one of the most iconic places to visit in Venice. Next, head to Uffizi Gallery, an astonishing art gallery, known for its history-steeped features.

In between the sights, don’t hesitate to take small detours to explore local stores and eateries. When you’re ready to continue your adventure, head to Basilica Of Santa Croce In Florence. This culturally significant church is a highly recommended experience. Nearby, you'll also find Hercules And Cacus and Piazza Della Signoria Visit these for an interesting touch to your journey.

When you’re done exploring for the day, you’ll drive to your hotel in Florence. Check in and relax before you head out to tour the city.

Florence is a place where the culinary landscape is as diverse as its attractions. So before the day ends, treat your palate to a taste of local cuisine at one of the best restaurants in Florence.

Enjoy a delicious meal at Ristorante Oliviero 1962, a highly-rated dining destination in Florence. If you're eager to try something different, consider Di Poneta Novoli, another top spot with a tantalizing menu. You might also want to secure a reservation at Caffe San Firenze. With a reputation for consistently satisfying customers, it’s an excellent choice to enhance your stay in Florence this evening.

After your meal, keep the night alive at a bar like Manifattura, known for its lively atmosphere. Se·sto On Arno Rooftop Bar is another top recommendation that provides the perfect setting with well-crafted drinks and a welcoming ambiance. Similarly, Il Vinile offers an excellent atmosphere for those looking to amp up the evening.

Say good night to Florence and look forward to another great day of your road trip in Italy!

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Day4

Day 4

  • Florence
  • Lucca
  • More

Drive 109 km, 2 hours 13 min

  • Cathedral of Santa Maria del Fiore
  • Galleria dell'Accademia
  • Piazza del Duomo, Pisa
  • Leaning Tower of Pisa
  • Walls of Lucca
  • More

On day 4 of your road trip in Italy, your travel plans include 3 stops at the most scenic, wondrous, and interesting places in the region. Florence, Pisa, and Lucca are on today's agenda. In the evening, you’ll end up in Lucca, where you will stay for 2 nights.

Enjoy all that Cathedral Of Santa Maria Del Fiore has to offer. This is an extraordinary church you should not miss. Another must-see is Galleria Dell'accademia, a popular art gallery in Florence.

When you’re ready for the next sight, head to Piazza Del Duomo, Pisa. From there, take a leisurely stroll to Leaning Tower Of Pisa, another of the city’s wondrous attractions. We recommend continuing your self-guided tour at Mura Di Lucca, a culturally significant place of interest in the city.

At the end of the day, you will drive to Lucca, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

Indulge in a memorable dining experience at one of Lucca's most popular restaurants, and connect with friendly locals for a true cultural experience.

Treat yourself to a delicious dinner at Gli Orti di Via Elisa, an excellent option for tonight's dining. Looking for something different? Bar Caffè Ristretto offers a tantalizing alternative with its diverse menu. And don’t miss Ristorante Schiaffino. Known for great service, it’s a fantastic choice for tonight in Lucca.

After your delicious meal, get a taste of the vibrant nightlife with a visit to Lebowski - Cocktail Bar, known for its inviting atmosphere. Blend is another great option if you’re looking for a place to get the night started. Similarly, Franklin'33 provides a great setting to enjoy the night away.

Raise your glass to another unforgettable day in Italy!

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Day5

Day 5

  • Lucca
  • More

Drive 226 km, 4 hours 24 min

  • Riomaggiore
  • Manarola Overlook Viewpoint
  • Cinque Terre National Park
  • Saint Andrew's Church
  • More

Greet day 5 of your road trip in Italy with a smile and start your day with a hearty breakfast. You have 1 night to stay in Lucca, so get ready to make the most of your time in the region. On the agenda for this day, you’ll find only the best things to see and do in Riomaggiore, Manarola, Corniglia, and Levanto.

Riomaggiore is brimming with adventures.

Catch Riomaggiore before the crowds roll in. Next, dive into the mesmerizing features of Manarola Overlook Viewpoint, a must-visit observation deck in the village.

In between sights, stop by local stores, picturesque photo spots, and small eateries. When you’re ready for your next attraction, proceed to Cinque Terre National Park, a locally renowned national park. For a change of scene, check out Saint Andrew's Church, known for its breathtaking features.

When you’re done exploring the area’s best attractions, you’ll drive back to your accommodation in Lucca.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Lucca. Enjoy a relaxing evening as you savor delicious local cuisine.

Enjoy a delicious meal at Osteria Nova, a top-rated dining destination in Lucca. If you're in the mood to try something new, consider La Bottega di Anna e Leo, another top spot with a mouthwatering menu. You might also want to secure a reservation at Ristorante Per 21. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Lucca this evening.

After savoring a delicious meal, step into the vibrant nightlife at La Tana Del Boia, where the evening is just getting started. In the same way, Vinarkia Della Pavona - Cocktail Bar offers a unique charm perfect for experiencing the local bar scene in Lucca. Magellano is another top-recommended bar that is sure to get you into the mood for some dancing and celebrating.

As the day draws to a close, take a moment to unwind and prepare for the next exciting chapter of your road trip in Italy.

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Day6

Day 6

  • Lucca
  • San Gimignano
  • More

Drive 185 km, 2 hours 46 min

  • Siena Cathedral
  • Pinacoteca Nazionale
  • piazza del Campo
  • Tower of Mangia
  • Parco della Rocca
  • Piazza del Duomo, San Gimignano
  • More

Experience an unparalleled adventure on day 6 of your road trip in Italy. This exciting part of your journey invites you to discover the renowned landmarks in 2 places, which are Siena and San Gimignano. At the end of the day, you will retreat to the hotel of your choice in San Gimignano, where will spend 1 night.

Siena Cathedral brings Lucca's character to life. This history-steeped church is a highlight of any visit in the city. Then, enjoy Pinacoteca Nazionale, another photogenic attraction that never fails to captivate visitors. Next, head over to Piazza Del Campo, one of the city’s most top-rated attractions, known for its visually striking features.

If you’re looking for more, spend time soaking in the atmosphere of Tower Of Mangia. This culturally significant monument is frequented by locals and tourists alike. To complete your memorable day, make sure to visit Parco Della Rocca, a worthwhile park, and take a stroll around the area. If you want to extend your self-guided sightseeing tour, go check out Piazza Del Duomo before you head back to your hotel.

After soaking up all the sights on today's itinerary, you'll be ready to head to your accommodation in San Gimignano. San Gimignano offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in San Gimignano. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Take some time to reflect on your day and savor another beautiful night in Italy.

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Day7

Day 7

  • San Gimignano
  • Rome
  • More

Drive 281 km, 4 hours 9 min

  • Castel Sant'Angelo
  • Piazza Navona
  • Pantheon
  • Trevi Fountain
  • Piazza di Spagna
  • Basilica di Santa Maria Maggiore
  • More

Dive into day 7 of your remarkable road trip in Italy. Today you'll explore 1 destination, including Rome. At the end of the day, you’ll unwind at one of the finest accommodations in Rome, where you'll spend 2 nights.

Check out the impressive castle, Castel Sant'angelo. Afterward, continue to Piazza Navona, a public square every traveler should visit. As you explore San Gimignano’s charming streets, take in the lively atmosphere and get to know the character of the city.

Next, make your way to Pantheon. This timeless monument is an essential stop. Following that, head to Trevi Fountain, another must-visit site that will enhance your experience. Don’t forget to stop by Piazza Di Spagna, a world-famous public square in the city. Finally, end your day with a visit to Basilica Di Santa Maria Maggiore, an UNESCO world heritage-designated church that offers the perfect conclusion to your sightseeing of the day.

When you’re done exploring for the day, you’ll drive to your hotel in Rome. Check in and relax before you head out to tour the city.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Rome, it's often a good idea to reserve a table in advance.

Have a fantastic dining experience at La Bottega Roma, a highly recommended choice for tonight's dinner. If you're looking to mix things up, Pasta In Corso offers an enticing alternative with its varied menu. Additionally, Trattoria Vecchia Roma is worth considering. Renowned for satisfying diners, it’s an ideal option for tonight in Rome.

Keep the evening going at La Botticella Of Poggi Giovanni, a great choice for enjoying the after-dinner hours with a drink. You could also go to Almalu Trastevere, which offers a similarly pleasant setting and great drinks. Another option is Bar Viminale Di Pepi Maurilio, which provides an inviting environment for unwinding after a busy day out.

Raise your glass and celebrate another amazing day of your road trip in Italy!

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Day8

Day 8

  • Rome
  • More

Drive 16 km, 1 hour 15 min

  • St Peter's Basilica
  • Colosseum
  • Roman Forum
  • Capitoline Hill
  • Altare della Patria
  • Archbasilica of St. John Lateran
  • More

Wake up to day 8 of your road trip in Italy. On this day, you’ll embark on an exciting expedition discovering the enchanting sights and activities of Vatican City and Rome. With 1 night to stay in Rome, we encourage you to seize the day and discover the unexplored beauty of the city’s surroundings!

Whether you decide to explore Vatican City on foot, use public transport, or join a guided tour, there are a few attractions you don’t want to miss.

Look forward to a unique sightseeing adventure at the timeless St. Peter's Basilica and allow yourself time to explore. Just a short distance away you'll find your next stop, Colosseum, a historic archeological site that draws visitors from far and near.

Continue your journey to Roman Forum, one of the city’s most world-famous spots that you shouldn’t miss. Another great site to visit is the interesting Capitoline Hill. When you're finished at the public square, Altare Della Patria awaits your visit. This monument is a culturally significant highlight on today's itinerary. Last up is a church - the locally renowned Archbasilica Of St. John Lateran.

When you’re done exploring for the day, you’ll return to Rome and your accommodation.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Rome, it's often a good idea to reserve a table in advance.

Make sure to reserve a table at RomAntica, an iconic dining spot in Rome. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Coso Ristorante, a popular restaurant in Rome. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of DEROMA - Farine Romane, a hidden gem nestled in Rome. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

Continue the enjoyment post-dinner at Sant' Eustachio Caffè, a cherished local gathering spot renowned for its welcoming atmosphere. Similarly, Yellowsquare Rome offers a vibrant space for indulging in well-crafted drinks and engaging conversation. You may also want to check out Caffè Portofino. This bar is a favorite among both locals and visitors looking for a delightful evening out filled with laughter and fun.

Relax and look forward to more memorable moments to come!

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Day9

Day 9

  • Rome
  • Venice
  • More

Drive 608 km, 7 hours 21 min

  • Piazza del Comune
  • Portico of Monte Frumentario
  • Basilica of San Francesco d'Assisi
  • More

Your itinerary for day 9 of your road trip in Italy includes 1 stop and features some of the highlights of Santa Maria degli Angeli. At the end of the day, enjoy the comforts of a top-rated hotel in Venice, where you'll spend 1 night.

Look forward to a unique sightseeing adventure at the locally appreciated Piazza Del Comune and allow yourself time to explore. Just a short distance away you'll find your next stop, Portico Of Monte Frumentario, a picture-perfect historical landmark that draws visitors from far and near.

Continue your journey to Basilica Of San Francesco D'assisi, one of the town’s most interesting spots that you shouldn’t miss.

At the end of the day, you will drive to Venice, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Venice. Enjoy a relaxing evening as you savor delicious local cuisine.

Make sure to reserve a table at Osteria Alla Staffa, an iconic dining spot in Venice. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Bistrot de Venise, a popular restaurant in Venice. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of Corte Sconta, a hidden gem nestled in Venice. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

Continue your evening by exploring the vibrant nightlife scene at Dolce Vita Venezia, a prime destination for a thrilling night out. Also, don’t forget to check out Tarnowska's American Bar, a bar that offers unique local touches. Likewise, Bar All'angolo provides an excellent alternative for a fun evening.

Celebrate another amazing day of your road trip adventure in Italy!

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Day10

Day 10

  • Venice - Departure day
  • More
  • Palazzo Contarini del Bovolo
  • More

Day 10 of your road trip in Italy is your departure day. This is your chance to catch a last glimpse of Venice before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

If you're up for some more sightseeing, begin at Palazzo Contarini Del Bovolo. This well-known palace is a hotspot among locals.

For a shopping spree in Venice, we recommend the lively Rialto Market. Here, you'll find a range of shops you can browse for some souvenir shopping.

Before you conclude your road trip in Italy, drop by another restaurant for a last chance at a memorable dining experience in Venice.

Enjoy a lovely meal at Cantina Do Spade, a top-rated place to have dinner tonight. Alternatively, if your taste buds call for something different, Trattoria Al Gazzettino is another top choice with a popular menu.

You’ll then say farewell to Venice. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Italy!

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Shortly after booking, you’ll receive your full itinerary, including schedules, locations, and everything you need for a stress-free trip.
Personalize your itinerary
Each package includes a professionally crafted itinerary you can tailor to your travel style. A dedicated travel expert will make sure every detail fits your needs perfectly.
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Need to update plans? No problem. Whether before your trip or mid-journey, we’re just seconds away to help with quick adjustments.
Enjoy seamless planning
With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.
Explore with confidence
From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.
Secure your spot
Confirm your package instantly and lock in the best rate with secure payment and guaranteed availability.
Get instant confirmation
Shortly after booking, you’ll receive your full itinerary, including schedules, locations, and everything you need for a stress-free trip.
Personalize your itinerary
Each package includes a professionally crafted itinerary you can tailor to your travel style. A dedicated travel expert will make sure every detail fits your needs perfectly.
Easily make changes
Need to update plans? No problem. Whether before your trip or mid-journey, we’re just seconds away to help with quick adjustments.
Enjoy seamless planning
With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.
Explore with confidence
From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.

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Your trip is protected, personalized, and priced right. No surprises, no stress.

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