10-Day Italy Self-Drive Road Trip With Itinerary from Venice to Florence, Lucca, San Gimignano, and Rome

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Experience the freedom of the open road in Italy as you embark on an unforgettable 10-day road trip! This experience caters to every traveler, featuring destinations like Venice, Murano, Florence, Pisa, Lucca, Riomaggiore, Manarola, Corniglia, Levanto, Siena, San Gimignano, Rome, and Santa Maria degli Angeli.

This perfectly planned road trip itinerary in Italy takes you through some of the best places to see in the country. You will spend 3 nights in Venice, 1 night in Florence, 2 nights in Lucca, 1 night in San Gimignano, and 2 nights in Rome. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Italy. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have got you covered.

Upon arriving in Venice, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Italy on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Italy. Trevi Fountain and Colosseum are just a couple of the bucket-list attractions that await your discovery. Marvel at the remarkable Pantheon, learn more about the unique Piazza Navona, and immerse yourself in the vibrant atmosphere of Piazza San Marco.

As you hit the open road and drive through Venice, Murano, Florence, Pisa, Lucca, Riomaggiore, Manarola, Corniglia, Levanto, Siena, San Gimignano, Rome, and Santa Maria degli Angeli, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Italy. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Italy.

Throughout your road trip in Italy, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Italy.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodation, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in Italy fill up quickly, so book your spot early. Select a date and start planning your road trip in Italy today!

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Itinerary summary

See a summary of the itinerary that you can fully customize

Days
Destination
Attractions
Overnight
Day
City & Overnight
Attractions
Rialto Bridge
Piazza San MarcoSt Mark's CampanileSt Mark's BasilicaDoge's PalaceBridge of SighsMurano
Ponte VecchioUffizi GalleryBasilica of Santa Croce in FlorenceHercules and Cacuspiazza della Signoria
Cathedral of Santa Maria del FioreGalleria dell'AccademiaPiazza del Duomo, PisaLeaning Tower of PisaWalls of Lucca
RiomaggioreManarola Overlook ViewpointCinque Terre National ParkSaint Andrew's Church
Siena CathedralPinacoteca Nazionalepiazza del CampoTower of MangiaParco della RoccaPiazza del Duomo, San Gimignano

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Day 1

Day 1

  • Venice - Arrival day
  • More
  • Rialto Bridge
  • More

Say hello to Venice! Your exciting road trip through Italy is just about to start. Navigating the top places to see in the region is a breeze with a car. The rental vehicle of your choice will be ready for pickup upon your arrival in the city. You will stay in Venice for 2 nights before you continue your adventure!

Venice is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out Rialto Bridge, or just taking a stroll in the city center. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

As afternoon approaches, head to your chosen hotel in Venice. Check-in typically starts around 2 to 4 PM at hotels in Italy. We recommend staying at a hotel in a central location for easy access to the best attractions, restaurants, and bars in the city.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Venice, it's often a good idea to reserve a table in advance.

Enjoy a delicious meal at Bauer Hotel, a highly-rated dining destination in Venice. If you're eager to try something different, consider L'Osteria Le Guglie, another top spot with a tantalizing menu. You might also want to secure a reservation at Corner Pub. With a reputation for consistently satisfying customers, it’s an excellent choice to enhance your stay in Venice this evening.

Continue your lively evening at Al Parlamento, a perfect place for winding down or revving up the night, depending on which mood you’re in. The Caffe Rosso is another excellent bar that offers a great selection of drinks to suit any mood. If you prefer to go somewhere else, Adagio ensures a night out tailored to your taste.

Raise a toast to the start of your 10-day road trip in Italy!

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Day 2

Day 2

  • Venice
  • More

Drive 14 km, 34 min

  • Piazza San Marco
  • St Mark's Campanile
  • St Mark's Basilica
  • Doge's Palace
  • Bridge of Sighs
  • Murano
  • More

At the end of the day, you'll drive back to Venice, where you'll stay for 1 night more.

Whether you prefer a leisurely exploration or a more fast-paced adventure, this itinerary in Venice allows for both. Start by heading to Piazza San Marco. This globally renowned public square provides an insightful glimpse into the city's identity. Next, discover St Mark's Campanile, a romantic monument, promising a delightful encounter.

Continue your sightseeing with a visit to St Mark's Basilica, a popular church. When you’re done, don’t forget to make a stop at the interesting Doge's Palace. Not far away from the palace, you will find the visually striking Murano, perfect for a quick visit. Round off your day at Bridge Of Sighs, another gem in Venice with enchanting features to discover.

When you’re done exploring the area’s best attractions, you’ll drive back to your accommodation in Venice.

As you explore more of Venice, you'll discover that its culinary landscape is as diverse as its attractions. Whether you're craving traditional dishes bursting with local flavors or innovative creations that push the boundaries of taste, you're sure to find a dining experience that satisfies your cravings.

Enjoy a delicious meal at Generator Venice, a top-rated dining destination in Venice. If you're in the mood to try something new, consider Nevodi, another top spot with a mouthwatering menu. You might also want to secure a reservation at Ristorante La Piazza. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Venice this evening.

Following your dinner, dive into the local bar culture at Il Mercante. Enjoy this evening's relaxed ambiance with delightful drinks. Alternatively, go to The Irish Pub Venezia, the perfect place for those looking to experience the best of the nightlife. Similarly, Ai Stagneri provides excellent drinks and a great atmosphere, ensuring a memorable night out.

Raise your glass and celebrate another amazing day of your road trip in Italy!

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Day 3

Day 3

  • Venice
  • Florence
  • More

Drive 263 km, 3 hours 20 min

  • Ponte Vecchio
  • Uffizi Gallery
  • Basilica of Santa Croce in Florence
  • Hercules and Cacus
  • piazza della Signoria
  • More

On day 3 of your road trip in Italy, you will get a true taste of the freedom a self-drive vacation in Europe entails. Today’s travel plans include stops at the most scenic, wondrous, and interesting places in Florence. In the evening, you’ll end up in Florence, where you will stay for 1 night.

Whether you prefer a leisurely exploration or a more fast-paced adventure, this itinerary in Venice allows for both. Start by heading to Ponte Vecchio. This wondrous historical landmark provides an insightful glimpse into the city's identity. Next, discover Uffizi Gallery, a romantic art gallery, promising a delightful encounter.

Continue your sightseeing with a visit to Basilica Of Santa Croce In Florence, a well-known church. When you’re done, don’t forget to make a stop at the beloved Hercules And Cacus. Round off your day at Piazza Della Signoria, another gem in Venice with romantic features to discover.

When you’re done exploring for the day, you’ll drive to your hotel in Florence. Check in and spend some time relaxing before you head out to tour the city.

As dinnertime approaches, it's time to head out for a bite to eat in Florence. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.

Dine in style at Ristorante Oliviero 1962, a top recommendation for dinner tonight. Or, for a change of pace, Di Poneta Novoli boasts a menu that's sure to impress. Also, be sure to check out Caffe San Firenze. Known as a local hotspot, it’s a great choice for tonight in Florence.

After enjoying a fulfilling meal, continue your evening at Manifattura, ideal for those looking to unwind with a drink in a comfortable setting. Alternatively, Se·sto On Arno Rooftop Bar offers a welcoming atmosphere for easing into the nightlife. Similarly, Il Vinile provides an excellent environment for a relaxed and enjoyable evening.

Savor another day of unforgettable experiences in Italy!

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Day 4

Day 4

  • Florence
  • Lucca
  • More

Drive 109 km, 2 hours 13 min

  • Cathedral of Santa Maria del Fiore
  • Galleria dell'Accademia
  • Piazza del Duomo, Pisa
  • Leaning Tower of Pisa
  • Walls of Lucca
  • More

Dive into day 4 of your remarkable road trip in Italy. Today you will explore Florence, Pisa, and Lucca, where you will have the opportunity to experience all the top things to see and do. At the end of the day, you’ll unwind at one of the finest accommodations in Lucca. You’ll stay here for 2 nights.

A blend of family-friendly attractions, romantic experiences, and scenic views await you in Florence on today’s itinerary. First up is the impressive church, Cathedral Of Santa Maria Del Fiore. Afterward, continue to Galleria Dell'accademia, an art gallery every traveler should visit.

As you explore Florence’s charming streets, take in the lively atmosphere and get to know the character of the city. Next, make your way to Piazza Del Duomo, Pisa. This iconic public square is an essential stop. Following that, head to Leaning Tower Of Pisa, another must-visit site that will enhance your experience. Don’t forget to stop by Mura Di Lucca, an increasingly popular historical landmark in the city.

After soaking up all the sights of today's itinerary, you'll be ready to head in the direction of your accommodation in Lucca. Lucca offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

After a day of adventure, treat yourself to an exquisite dinner at one of Lucca's best restaurants.

Treat yourself to a delightful dinner at Gli Orti di Via Elisa, highly recommended for tonight's dining. Or, if you're feeling adventurous, why not try Bar Caffè Ristretto? It's another excellent option with a diverse menu. Consider reserving a table at Ristorante Schiaffino as well. Known for its consistent customer satisfaction, it’s an ideal pick for tonight in Lucca.

Cap off your dinner by heading to Lebowski - Cocktail Bar, ideal for a leisurely evening with a drink in hand. Blend is another bar that offers an enjoyable setting. Similarly, Franklin'33 is also a popular place to go on a night out, perfect for relaxing and socializing.

Relax and reminisce about your day in Italy and look forward to more memorable moments to come!

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Day 5

Day 5

  • Lucca
  • More

Drive 226 km, 4 hours 24 min

  • Riomaggiore
  • Manarola Overlook Viewpoint
  • Cinque Terre National Park
  • Saint Andrew's Church
  • More

On day 5 of your road trip in Italy, you’ll start and end your day in Lucca, but spend the day exploring what’s beyond the city. Since you will return to Lucca for 1 night more, there’s no need to rush. Experience Riomaggiore, Manarola, Corniglia, and Levanto to the fullest today with this curated day itinerary!

Enjoy the perfect balance of relaxation and exploration in Lucca today. One of the most worthwhile attractions included on the itinerary is Riomaggiore. Then, take a leisurely stroll to Manarola Overlook Viewpoint and learn what makes this serene observation deck unique.

Throughout the day, make sure to take breaks to appreciate the surroundings. Next up, visit the captivating Cinque Terre National Park. After exploring the national park, head to Saint Andrew's Church. This frequently visited church is a highlight in Lucca.

When you’re done exploring for the day, you’ll return to Lucca and your accommodation.

As dinnertime approaches, it's time to head out for a bite to eat in Lucca. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.

Enjoy a lovely meal at Osteria Nova, a top-rated place to have dinner tonight. Alternatively, if your taste buds call for something different, La Bottega di Anna e Leo is another top choice with a popular menu. You could also check for a table at Ristorante Per 21. As an establishment that gains consistently high praises from customers, it’s an ideal choice in Lucca tonight.

After your delicious meal, get a taste of the vibrant nightlife with a visit to La Tana Del Boia, known for its inviting atmosphere. Vinarkia Della Pavona - Cocktail Bar is another great option if you’re looking for a place to get the night started. Similarly, Magellano provides a great setting to enjoy the night away.

Savor another day of unforgettable experiences in Italy!

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Day 6

Day 6

  • Lucca
  • San Gimignano
  • More

Drive 185 km, 2 hours 46 min

  • Siena Cathedral
  • Pinacoteca Nazionale
  • piazza del Campo
  • Tower of Mangia
  • Parco della Rocca
  • Piazza del Duomo, San Gimignano
  • More

Experience an unparalleled adventure on day 6 of your road trip in Italy. This exciting part of your journey invites you to discover the renowned landmarks in 2 vibrant destinations - Siena and San Gimignano. After a day filled with exploration and new experiences, you will retreat to the hotel of your choice in San Gimignano. You will spend 1 night here for some well-deserved relaxation.

Get ready for a day filled with fun adventures, romantic experiences, and scenic views in the charming city of Lucca. Your adventure starts at Siena Cathedral, a locally renowned local hot spot. Another notable attraction to explore is Pinacoteca Nazionale. This increasingly popular art gallery is known for its visually striking appeal.

After soaking in the highlights of these sights, take some time to wander Lucca's streets and immerse yourself in the local atmosphere. When you're ready to continue your sightseeing adventure, head to Piazza Del Campo. This visually striking public square offers a fascinating experience that many visitors find memorable. Tower Of Mangia is also worth visiting, along with Parco Della Rocca. These standout landmarks offer unique experiences that add to the day’s enjoyment. End your day at Piazza Del Duomo. This locally appreciated public square provides a fitting finale to your sightseeing.

At the end of the day, you will drive to San Gimignano, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in San Gimignano. Enjoy a relaxing evening as you savor delicious local cuisine and reflect on the day's adventures.

Relax and recharge in preparation for another adventurous day in Italy!

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Day 7

Day 7

  • San Gimignano
  • Rome
  • More

Drive 281 km, 4 hours 9 min

  • Castel Sant'Angelo
  • Piazza Navona
  • Pantheon
  • Trevi Fountain
  • Piazza di Spagna
  • Basilica di Santa Maria Maggiore
  • More

Embark on another extraordinary experience on day 7 of your road trip in Italy. Today, you will make 1 stop and experience some of the highlights of Rome. At the end of the day, you will enjoy the comforts of a top-rated hotel in Rome, which will be your home away from home for 2 nights.

Today's adventure in San Gimignano promises more breathtaking discoveries and enriching experiences! Begin at Castel Sant'angelo. This visually striking castle is a highlight of any visit in the city. Then, enjoy Piazza Navona, another grand attraction that never fails to captivate visitors. Next, head over to Pantheon, one of the city’s most wondrous attractions, known for its culturally significant features.

If you’re looking for more, spend time soaking in the atmosphere of Trevi Fountain. This visually striking monument is frequented by locals and tourists alike. To complete your memorable day, make sure to visit Piazza Di Spagna, a wondrous public square, and take a stroll around the area. If you want to extend your self-guided sightseeing tour, go check out Basilica Di Santa Maria Maggiore before you head back to your hotel.

When you’re done exploring for the day, you’ll drive to your hotel in Rome. Check in and spend some time relaxing before you head out to tour the city.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Rome. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Have a fantastic dining experience at La Bottega Roma, a highly recommended choice for tonight's dinner. If you're looking to mix things up, Pasta In Corso offers an enticing alternative with its varied menu. Additionally, Trattoria Vecchia Roma is worth considering. Renowned for satisfying diners, it’s an ideal option for tonight in Rome.

After savoring a delicious meal, step into the vibrant nightlife at La Botticella Of Poggi Giovanni, where the evening is just getting started. In the same way, Almalu Trastevere offers a unique charm perfect for experiencing the local bar scene in Rome. Bar Viminale Di Pepi Maurilio is another top-recommended bar that is sure to get you into the mood for some dancing and celebrating.

Get a good night's sleep and look forward to another great day on the road in Italy!

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Day 8

Day 8

  • Rome
  • More

Drive 16 km, 1 hour 15 min

  • St Peter's Basilica
  • Colosseum
  • Roman Forum
  • Capitoline Hill
  • Altare della Patria
  • Archbasilica of St. John Lateran
  • More

On day 8 of your road trip, you’ll start and end your day in Rome, but spend part of the day exploring places of interest outside the immediate city. On today's itinerary, you'll find attractions in Vatican City and Rome. You still have 1 night left in Rome.

Get ready for a day filled with family-friendly attractions, scenic views, and picturesque spots in the charming city of Rome. Your adventure starts at St. Peter's Basilica, an iconic local hot spot. Another notable attraction to explore is Colosseum.

After soaking in the highlights of these sights, take some time to wander Rome's streets and immerse yourself in the local atmosphere. When you're ready to continue your sightseeing adventure, head to Roman Forum. This historic archeological site offers a fascinating experience that many visitors find memorable. Capitoline Hill is also worth visiting, along with Altare Della Patria. These standout landmarks offer unique experiences that add to the day’s enjoyment. End your day at Archbasilica Of St. John Lateran. This notable church provides a fitting finale to your sightseeing.

When you’re done exploring the area’s best attractions, you’ll drive back to your accommodation in Rome.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Rome. Enjoy a relaxing evening as you savor delicious local cuisine and reflect on the day's adventures.

Don’t miss out on dining at RomAntica, a top-rated dining destination in Rome. If you're in the mood to try something new, consider Coso Ristorante, another top spot with a mouthwatering menu. You might also want to secure a reservation at DEROMA - Farine Romane. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Rome this evening.

Continue your evening by exploring the vibrant nightlife scene at Sant' Eustachio Caffè, a prime destination for a thrilling night out. Also, don’t forget to check out Yellowsquare Rome, a bar that offers unique local touches. Likewise, Caffè Portofino provides an excellent alternative for a fun evening.

As the day draws to a close, take a moment to unwind and prepare for the next exciting chapter of your road trip in in Italy.

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Day 9

Day 9

  • Rome
  • Venice
  • More

Drive 608 km, 7 hours 21 min

  • Piazza del Comune
  • Portico of Monte Frumentario
  • Basilica of San Francesco d'Assisi
  • More

On day 9 of your exciting self-drive vacation in Italy, you’ll soak in the magnificence of 1 destination, Santa Maria degli Angeli. When you’re not sightseeing, take time to relax at your selected hotel in Venice, where you’ll be staying for 1 night.

Today’s route brings fun adventures, romantic experiences, and breathtaking views. The first attraction of today is Piazza Del Comune. This curiosity-inducing public square is a history-steeped place to see in Rome. Continue your discovery at Portico Of Monte Frumentario, a historic historical landmark with stories to tell.

As you stroll around Rome, take in the distinct atmosphere and learn what makes this town so unique. Maximize your sightseeing with a visit to Basilica Of San Francesco D'assisi. This locally renowned church offers a historic encounter with Rome. Whether you decide to get entrance tickets for all attractions or you prefer admiring from a distance, amazing experiences await on this day in Rome.

After soaking up all the sights of today's itinerary, you'll be ready to head in the direction of your accommodation in Venice. Venice offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

As you explore more of Venice, you'll discover that its culinary landscape is as diverse as its attractions. Whether you're craving traditional dishes bursting with local flavors or innovative creations that push the boundaries of taste, you're sure to find a dining experience that satisfies your cravings.

Enjoy a delicious meal at Osteria Alla Staffa, a top-rated dining destination in Venice. If you're in the mood to try something new, consider Bistrot de Venise, another top spot with a mouthwatering menu. You might also want to secure a reservation at Corte Sconta. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Venice this evening.

Keep the evening going at Dolce Vita Venezia, a great choice for enjoying the after-dinner hours with a drink. You could also go to Tarnowska's American Bar, which offers a similarly pleasant setting and great drinks. Another option is Bar All'angolo, which provides an inviting environment for unwinding after a busy day out.

Celebrate another amazing day of your road trip adventure in Italy!

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Day 10

Day 10

  • Venice - Departure day
  • More
  • Palazzo Contarini del Bovolo
  • More

Day 10 of your road trip in Italy is your departure day. This is your chance to catch a last glimpse of Venice before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

If you're up for some more sightseeing, begin at Palazzo Contarini Del Bovolo. This notable palace is a popular place to see in the city.

On your last day in Italy, take time to indulge in shopping at Venice’s popular marketplace, Calle Larga XXII Marzo. Look for keepsakes or souvenirs to remind you of your trip. If you’re in the mood for luxury shopping, high-end stores await you.

Before you conclude your road trip in Italy, drop by another restaurant for a last chance at a memorable dining experience in Venice.

Treat yourself to a delicious dinner at Cantina Do Spade, an excellent option for tonight's dining. Looking for something different? Trattoria Al Gazzettino offers a tantalizing alternative with its diverse menu. And don’t miss Local.

You’ll then say farewell to Venice. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Italy!

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