11-Day Italy Self-Drive Road Trip With Itinerary from Perugia traveling south to L'aquila, Naples, Rome, and Siena

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Porta di Venere, from the Roman era, made of white travertine, with its three arches and the two towers of Properzio in Perugia, Italy
Photo of Christmas in Assisi, Saint Francis Basilica with the Christmas Crib. Province of Perugia, Umbria, Italy.
11-Day Italy Self-Drive Road Trip With Itinerary from Perugia traveling south to L'aquila, Naples, Rome, and Siena
11-Day Italy Self-Drive Road Trip With Itinerary from Perugia traveling south to L'aquila, Naples, Rome, and Siena
11-Day Italy Self-Drive Road Trip With Itinerary from Perugia traveling south to L'aquila, Naples, Rome, and Siena
11-Day Italy Self-Drive Road Trip With Itinerary from Perugia traveling south to L'aquila, Naples, Rome, and Siena
11-Day Italy Self-Drive Road Trip With Itinerary from Perugia traveling south to L'aquila, Naples, Rome, and Siena
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Explore the best of Italy on a remarkable 11-day road trip! Combine exploration with relaxation on a self-drive tour featuring Perugia, L'aquila, Caserta, Pompei, Naples, Amalfi, Rome, Siena, and Santa Maria degli Angeli.

This perfectly planned road trip itinerary takes you through some of the best places to see in Italy. You will spend 2 nights in Perugia, 1 night in L'aquila, 2 nights in Naples, 3 nights in Rome, and 2 nights in Siena. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Italy. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have you covered.

Upon arriving in Perugia, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Italy on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Italy. Trevi Fountain and Colosseum are just a couple of the bucket-list attractions that await your discovery.

As you hit the open road and drive through Perugia, L'aquila, Caserta, Pompei, Naples, Amalfi, Rome, Siena, and Santa Maria degli Angeli, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Italy. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Italy.

Throughout your road trip in Italy, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Italy.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodations, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in Italy fill up quickly, so book your spot early. Select a date and start planning your road trip in Italy today!

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Day1

Day 1

  • Perugia - Arrival day
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  • Piazza IV Novembre
  • More

Your road trip adventure in Italy begins as soon as you reach Perugia and pick up your car. You’ll stay here for 1 night and explore what to see in Perugia, sample the local cuisine, and choose from a curated selection of the best hotels and places to stay in the city.

Perugia is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out Piazza Iv Novembre. Taking a stroll in the city center is a great alternative. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

When you're ready for some downtime, make your way to your chosen hotel. Check-in typically starts between 2 and 4 PM in Perugia. Make yourself at home and unwind before heading out again.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Perugia, it's often a good idea to reserve a table in advance.

Don’t miss out on dining at Ristorante Settimo Sigillo, a top-rated dining destination in Perugia. If you're in the mood to try something new, consider Caffè Baglioni, another top spot with a mouthwatering menu. You might also want to secure a reservation at Bar Pellas. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Perugia this evening.

Extend your evening after a delightful meal by visiting Tommi Bar, which offers the perfect atmosphere for a night out. Moreover, Valentina is another popular option for a drink or two. Likewise, Caffe Dal Perugino also provides a great ambiance for reminiscing about the day and raising a toast to your vacation.

Raise a toast to the start of your 11-day road trip in Italy!

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Day2

Day 2

  • Perugia
  • L'Aquila
  • More

Drive 172 km, 2 hours 47 min

  • Carducci Gardens
  • Porta Marzia
  • Rocca Paolina
  • National Archaeological Museum of Umbria
  • More

Your itinerary for day 2 of your road trip in Italy includes 1 stop and features some of the highlights of Perugia. At the end of the day, enjoy the comforts of a top-rated hotel in L'aquila, where you'll spend 1 night.

Carducci Gardens is must-visit park and a great option for a daytime tour of the area. Continue your journey to Porta Marzia, an up-and-coming monument, located just a leisurely stroll away. Next, head to Rocca Paolina, a symbolic historical landmark, also available for your discovery today.

After soaking up all the sights on today's itinerary, you'll be ready to head to your accommodation in L'aquila. L'aquila offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

L'aquila is a place where the culinary landscape is as diverse as its attractions. So before the day ends, treat your palate to a taste of local cuisine at one of the best restaurants in L'aquila.

Dive into a culinary adventure like no other in L'aquila by booking a table at FØRMA contemporary restaurant. This popular restaurant holds a Bib Gourmand award and offers an exceptional menu of contemporary and creative cuisine. If you're in the mood to try something new, consider DECA, another top spot with a mouthwatering menu.

Keep the evening going at Art Cafè L'aquila, a great choice for enjoying the after-dinner hours with a drink.

Take some time to reflect on your day and savor another beautiful night in Italy.

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Day3

Day 3

  • L'Aquila
  • Caserta
  • Pompei
  • Naples
  • More

Drive 282 km, 4 hours 5 min

  • Palace of Caserta
  • Giardini Reali - Parco Reggia di Caserta
  • Archaeological Park of Pompeii
  • Teatro Grande
  • More

On day 3 of your exciting self-drive vacation in Italy, you’ll soak in the magnificence of 2 destinations, including Caserta and Pompei. When you’re not sightseeing, take time to relax at your chosen hotel in Naples, where you’ll be staying for 2 nights.

Set your GPS to Caserta and hit the road. Expect a journey of approximately 2 hours 35 min without stops. Soak in the beautiful landscapes as you drive and look forward to exploring your next destination. Caserta beckons with new experiences!

When you're ready for some sights, head to Palace Of Caserta, a notable palace in Caserta. Explore its history-steeped features at your own pace before you continue your journey to your next attraction, Giardini Reali - Parco Reggia Di Caserta. This interesting park is a top recommendation in the area.

When you’ve had your share of Caserta, prepare for your next destination. Admire the views and listen to some good music as you drive in the direction of Pompei. Your travel time is around 43 min.

When you're ready for some sights, head to Archaeological Park Of Pompeii, a captivating archeological site in Pompei. Explore its stunning features at your own pace before you continue your journey to your next attraction, Teatro Grande. This increasingly popular archeological site is a top recommendation in the area.

At the end of the day, you will drive to Naples, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Naples, it's often a good idea to reserve a table in advance.

Experience a taste of local culinary excellence while in Naples by securing a table at Veritas. An esteemed 1-star Michelin restaurant, it features an exceptional campanian and contemporary menu. For an alternative taste experience, visit Il Comandante, famous for its scrumptious creative and mediterranean dishes. This 1-star Michelin venue consistently impresses guests, making it a standout addition to your holiday plans. Looking for another choice? Discover ARIA, a local favorite celebrated for its exquisite contemporary and modern cuisine in Naples. Located in the heart of the city, this 1-star Michelin restaurant is an ideal pick for contemporary and modern cuisine lovers seeking top-notch culinary experiences.

Continue your lively evening at Happening Cocktail Bar, a perfect place for winding down or revving up the night, depending on which mood you’re in. Shanti Art Musik Bar is another excellent bar that offers a great selection of drinks to suit any mood. If you prefer to go somewhere else, Gran Caffè Gambrinus ensures a night out tailored to your taste.

Raise your glass to another unforgettable day in Italy!

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Day4

Day 4

  • Naples
  • Amalfi
  • More

Drive 126 km, 3 hours 36 min

  • Amalfi Coast
  • Castel Nuovo
  • piazza del Plebiscito
  • Ovo Castle
  • Via Toledo
  • More

Greet day 4 of your road trip in Italy with a smile and start your day with a hearty breakfast. You have 1 night to stay in Naples, so get ready to make the most of your time in the region. On the agenda for this day, you’ll find only the best things to see and do in Amalfi and Naples.

Via Toledo is one of the highlights of today. Take your time exploring this iconic street in Amalfi, which offers a perfect blend of history and culture. Plus, it's close to many must-see landmarks in the village.

Castel Nuovo is perfect for a self-paced visit during the day. This culturally significant castle is sure to impress. Next on your list is Piazza Del Plebiscito, another must-visit landmark and widely recognized public square renowned for its enchanting features.

While exploring and sightseeing, take time to savor the culture of Naples by sampling some local delicacies. When you’re ready for more sightseeing, head to Ovo Castle. This symbolic castle is an essential place to visit for anyone looking for the full Naples experience.

Continue your road trip and head to your next destination, Amalfi. This car ride takes around 1 hour 26 min.

For a more meaningful self-guided tour of the village's best attractions, visit Amalfi Coast, an astonishing coast that is sure to impress. Take in the surroundings and enjoy the freedom of exploring at your own pace before you continue your journey.

When you’re done exploring for the day, you’ll return to Naples and your accommodation.

Naples is a place where the culinary landscape is as diverse as its attractions. So before the day ends, treat your palate to a taste of local cuisine at one of the best restaurants in Naples.

Treat yourself to a wonderful meal at Antica Pizzeria Di Matteo, a top-rated dining spot in Naples. If you're in the mood for something new, try Mercure Napoli Centro Angioino, another premier location with a delectable menu. You might also want to book a table at La Lazzara Trattoria e Pizzeria. Known for its consistently satisfied patrons, it’s a perfect choice to elevate your evening in Naples.

If you’re not ready to end the night just yet, Archivio Storico - Cocktail Bar & Wonderfood offers a perfect venue to relax and savor a drink. Similarly, Archeobar is well-suited for those looking to unwind in a social setting. Babette Pub is another excellent spot to enjoy a nightcap after a delightful meal.

Say good night to Naples and look forward to another great day of your road trip in Italy!

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Day5

Day 5

  • Naples
  • Vatican City
  • Rome
  • More

Drive 241 km, 3 hours 29 min

  • St Peter's Basilica
  • Sistine Chapel
  • Saint Peter's Square
  • Vatican Museums
  • More

Dive into day 5 of your remarkable road trip in Italy. Today you'll explore 1 destination, including Vatican City. At the end of the day, you’ll unwind at one of the finest accommodations in Rome, where you'll spend 3 nights.

Once you're ready to continue your road trip, it's time to buckle up and drive towards Vatican City, eagerly anticipating your arrival in Vatican City. This drive usually takes around 2 hours 40 min, without any stops or traffic disruptions.

Next, continue your sightseeing at Sistine Chapel, a famous chapel.

Make sure to also explore Vatican Museums, a world-famous art museum.

When you’re done exploring for the day, you’ll drive to your hotel in Rome. Check in and relax before you head out to tour the city.

Indulge in a memorable dining experience at one of Rome's most popular restaurants, and connect with friendly locals for a true cultural experience.

Discover the culinary delights of Rome by securing a reservation at La Pergola. Esteemed for its 3-star Guide Michelin recognition, this restaurant offers a remarkable selection of mediterranean and contemporary cuisine. For an alternative dining experience, try Il Pagliaccio, renowned for its delicious creative and innovative dishes. This esteemed 2-star Michelin-recipient consistently impresses guests, making it a must-visit spot during your holiday. Craving more culinary excitement? Head to Enoteca La Torre, a highly recommended local eatery celebrated for its mouthwatering mediterranean and creative menu. With its 2-star Michelin recognition, it offers an unforgettable dining adventure.

After savoring a delicious meal, step into the vibrant nightlife at La Botticella Of Poggi Giovanni, where the evening is just getting started. In the same way, Almalu Trastevere offers a unique charm perfect for experiencing the local bar scene in Rome. Bar Viminale Di Pepi Maurilio is another top-recommended bar that is sure to get you into the mood for some dancing and celebrating.

As the sun sets, rest up and recharge for the next leg of your road trip in Italy.

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Day6

Day 6

  • Rome
  • More

Drive 11 km, 1 hour 19 min

  • Castel Sant'Angelo
  • Piazza Navona
  • Pantheon
  • Trevi Fountain
  • Villa Borghese
  • More

Day 6 of your road trip across Italy promises a magnificent time exploring what to see in Rome. You have 2 nights left in Rome. Take the opportunity to experience more of the best attractions and activities in the city.

Awaiting your discovery is the astonishing Castel Sant'angelo, a history-steeped castle in Rome. Next, go to Piazza Navona.

After visiting Castel Sant'angelo and Piazza Navona, have a stroll along Rome's streets and take in the local charm. Continue your sightseeing by heading to Pantheon. This heritage-rich monument offers a unique experience. Trevi Fountain is another noteworthy attraction worthwhile a visit. End your self-guided sightseeing tour on top with a visit to Villa Borghese, one of the most eye-catching places to visit in Rome.

Don’t forget to check out all the popular tours and experiences you can add to your travel plans in Italy. You can explore and select activities under each day of your itinerary.

After a day of adventure, treat yourself to an exquisite dinner at one of Rome's best restaurants.

Savor the flavors at RomAntica, a top pick for dinner tonight. Alternatively, Coso Ristorante beckons with its unique menu offerings. Also, consider DEROMA - Farine Romane. With its consistent customer satisfaction, it’s an excellent option for dining in Rome tonight.

After savoring a delicious meal, step into the vibrant nightlife at Sant' Eustachio Caffè, where the evening is just getting started. In the same way, Yellowsquare Rome offers a unique charm perfect for experiencing the local bar scene in Rome. Caffè Portofino is another top-recommended bar that is sure to get you into the mood for some dancing and celebrating.

Raise your glass and celebrate another amazing day of your road trip in Italy!

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Day7

Day 7

  • Rome
  • More

Drive 3 km, 41 min

  • Altare della Patria
  • Roman Forum
  • Colosseum
  • Trastevere
  • Monti
  • More

On day 7 of your road trip, you will have an entire day to discover what to see in Rome. You’ll stay in Rome for 1 night.

Trastevere is one of the highlights of today. Take your time exploring this iconic neighborhood in Rome, which offers a perfect blend of history and culture. Plus, it's close to many must-see landmarks in the city. Be sure to also visit Monti, a neighborhood that showcases another side of Rome.

Enjoy all that Altare Della Patria has to offer. This is a captivating monument you should not miss. Another must-see is Roman Forum, a wondrous archeological site in Rome.

When you’re ready for the next sight, head to Colosseum.

Don’t forget to check out all the popular tours and experiences you can add to your travel plans in Italy. You can explore and select activities under each day of your itinerary.

Rome is a place where the culinary landscape is as diverse as its attractions. So before the day ends, treat your palate to a taste of local cuisine at one of the best restaurants in Rome.

Have a fantastic dining experience at Hotel de Russie, a highly recommended choice for tonight's dinner. If you're looking to mix things up, La Taverna Italiana offers an enticing alternative with its varied menu. Additionally, The Parrot Bar is worth considering. Renowned for satisfying diners, it’s an ideal option for tonight in Rome.

To truly maximize your evening out, consider visiting The Apartment Bar Roma after dinner. This bar is known for offering some of the best drinks and vibes in the city. Alternatively, head to Hotel Hassler Roma, another bar with an inviting ambiance.

Say good night to Rome and look forward to another great day of your road trip in Italy!

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Day8

Day 8

  • Rome
  • Siena
  • More

Drive 239 km, 3 hours 11 min

  • Piazza di Spagna
  • Spanish Steps
  • piazza del Popolo
  • More

On day 8 of your road trip in Italy, your travel plans include 1 stop at the most scenic, wondrous, and interesting places in the region. Rome are on today's agenda. In the evening, you’ll end up in Siena, where you will stay for 2 nights.

Visiting Piazza Di Spagna is always a good idea. This world-famous public square is a place that is appreciated by travelers and locals alike. Next, immerse yourself in the history-steeped wonders of Spanish Steps, a must-see public square in the city.

Consider stopping for a small bite to eat or a drink at a local eatery to keep your energy going. When you’re ready, continue your discovery with a visit to Piazza Del Popolo. This top-rated public square offers an enriching experience.

After soaking up all the sights on today's itinerary, you'll be ready to head to your accommodation in Siena. Siena offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

After a day of adventure, treat yourself to an exquisite dinner at one of Siena's best restaurants.

Enjoy a lovely dining experience at Enoteca I Terzi, a popular restaurant in Siena. This acclaimed establishment has earned the admiration of countless food lovers in the city. Alternatively, experience a taste of Siena at Ristorante Tar-Tufo, another great place to eat. With a menu designed to impress, it promises a journey of flavors that will leave you captivated. A third option to check out is the top-rated Antica Trattoria Papei. It’s yet another ideal choice to enhance your time in Siena tonight.

After your delicious meal, get a taste of the vibrant nightlife with a visit to Meet Life Cafè, known for its inviting atmosphere. Maudit Pub is another great option if you’re looking for a place to get the night started. Similarly, Bar Impero Siena provides a great setting to enjoy the night away.

Relax and look forward to more memorable moments to come!

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Day9

Day 9

  • Siena
  • More

Drive 3 km, 44 min

  • Fortezza Medicea
  • Loggia del Papa, Siena
  • piazza del Campo
  • Opera delle Metropolitana
  • Siena Cathedral
  • More

Day 9 of your road trip will take you to the best attractions Siena has to offer. Cherish the 1 night you have left in the city and use the provided itinerary to discover what to see in Siena.

Visiting Fortezza Medicea (siena) is always a good idea. This locally appreciated monument is a place that is appreciated by travelers and locals alike. Next, immerse yourself in the eye-catching wonders of Loggia Del Papa, Siena, a must-see monument in the city.

Consider stopping for a small bite to eat or a drink at a local eatery to keep your energy going. When you’re ready, continue your discovery with a visit to Piazza Del Campo. This impressive public square offers an enriching experience. For a change of pace, head to Opera Delle Metropolitana, where you can take in picture-perfect features. Conclude your self-guided sightseeing tour with a visit to Siena Cathedral These sights offer a fulfilling end to a perfect day.

Don’t forget to check out all the popular tours and experiences you can add to your travel plans in Italy. You can explore and select activities under each day of your itinerary.

Indulge in a memorable dining experience at one of Siena's most popular restaurants, and connect with friendly locals for a true cultural experience.

Treat yourself to a delicious dinner at Osteria Quattro Venti, an excellent option for tonight's dining. Looking for something different? Fischi per Fiaschi offers a tantalizing alternative with its diverse menu. And don’t miss Osteria da Divo. Known for great service, it’s a fantastic choice for tonight in Siena.

Let the evening flow smoothly from dinner to drinks at Charlie Mixology Bar Di Aldinucci Riccardo, a top-rated bar in the area. For other recommendations, Bar Pinacoteca provides a perfect setting for rounding out your night with style and great drinks. Likewise, San Paolo Pub offers a memorable night with diverse drink options and excellent service.

Relax and recharge in preparation for another adventurous day in Italy!

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Day10

Day 10

  • Siena
  • Assisi
  • Santa Maria degli Angeli
  • Perugia
  • More

Drive 156 km, 2 hours 38 min

  • Basilica of San Francesco d'Assisi
  • Cathedral of San Rufino
  • Basilica di Santa Chiara
  • Basilica of Santa Maria degli Angeli
  • More

Experience an unparalleled adventure on day 10 of your road trip in Italy. This exciting part of your journey invites you to discover the renowned landmarks in 1 place, which are Santa Maria degli Angeli. At the end of the day, you will retreat to the hotel of your choice in Perugia, where will spend 1 night.

When you’re ready to jump back into the car and say goodbye to Siena, you’ll hit the road in the direction of Santa Maria degli Angeli. This drive usually takes around 1 hour 36 min.

Savor the day by heading to Basilica Of San Francesco D'assisi, a locally renowned church that draws visitors from near and far. When you're done, continue to Cathedral Of San Rufino, where you can soak in the culturally significant surroundings.

Next, explore Basilica Di Santa Chiara, yet another underrated place to see in the area.

Set your GPS to Santa Maria degli Angeli and hit the road. Expect a journey of approximately 11 min without stops. Soak in the beautiful landscapes as you drive and look forward to exploring your next destination. Santa Maria degli Angeli beckons with new experiences!

Set out on a self-guided sightseeing tour at Basilica Of Santa Maria Degli Angeli and explore the breathtaking features.

At the end of the day, you will drive to Perugia, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Perugia. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Enjoy a lovely meal at La Taverna, a top-rated place to have dinner tonight. Alternatively, if your taste buds call for something different, Ristorante del Sole is another top choice with a popular menu. You could also check for a table at Al Mangiar Bene. As an establishment that consistently gains high praises from customers, it’s an ideal choice in Perugia tonight.

Round off your dining experience by visiting Caffè Fortebraccio, a prime location for a drink. Alternatively, explore the distinctive characteristics of Caffe Del Banco, a bar catering to every mood and preference. Dempsey's Perugia likewise offers a unique atmosphere, perfect for a memorable night out.

Celebrate another amazing day of your road trip adventure in Italy!

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Day11

Day 11

  • Perugia - Departure day
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  • Etruscan Arch
  • More

Day 11 of your road trip in Italy is your departure day. This is your chance to catch a last glimpse of Perugia before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

If you're up for some more sightseeing, we recommend visiting Etruscan Arch, an instagrammable historical landmark before you head out.

Before you conclude your road trip in Italy, drop by another restaurant for a last chance at a memorable dining experience in Perugia.

If you're in the mood for something new, try Elfo Pub Perugia, another premier location with a delectable menu.

You’ll then say farewell to Perugia. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Italy!

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Secure your spot
Confirm your package instantly and lock in the best rate with secure payment and guaranteed availability.
Get instant confirmation
Shortly after booking, you’ll receive your full itinerary, including schedules, locations, and everything you need for a stress-free trip.
Personalize your itinerary
Each package includes a professionally crafted itinerary you can tailor to your travel style. A dedicated travel expert will make sure every detail fits your needs perfectly.
Easily make changes
Need to update plans? No problem. Whether before your trip or mid-journey, we’re just seconds away to help with quick adjustments.
Enjoy seamless planning
With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.
Explore with confidence
From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.

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