11-Day Italy Self-Drive Road Trip With Itinerary from Perugia traveling south to L'aquila, Naples, Rome, and Siena
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Explore the best of Italy on a 11-day road trip! Uncover hidden gems and experience the rich culture firsthand as you journey through Perugia, L'aquila, Caserta, Pompei, Naples, Amalfi, Rome, Siena, and Santa Maria degli Angeli. This road trip itinerary in Italy seamlessly combines exploration with relaxation.
This perfectly planned road trip itinerary in Italy takes you through some of the best places to see in the country. You will spend 2 nights in Perugia, 1 night in L'aquila, 2 nights in Naples, 3 nights in Rome, and 2 nights in Siena. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!
With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Italy. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have got you covered.
Upon arriving in Perugia, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Italy on your own terms.
An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Italy. Trevi Fountain and Colosseum are just a couple of the bucket-list attractions that await your discovery. Marvel at the remarkable Pantheon, learn more about the unique Piazza Navona, and immerse yourself in the vibrant atmosphere of St. Peter's Basilica.
As you hit the open road and drive through Perugia, L'aquila, Caserta, Pompei, Naples, Amalfi, Rome, Siena, and Santa Maria degli Angeli, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Italy. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Italy.
Throughout your road trip in Italy, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Italy.
This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodation, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.
The best services in Italy fill up quickly, so book your spot early. Select a date and start planning your road trip in Italy today!
Itinerary summary
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Day 1
- Perugia - Arrival day
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- Piazza IV Novembre
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Your road trip adventure in Italy begins as soon as you reach Perugia and pick up your car. You’ll stay in Perugia for 1 night and explore the best things to see and do, sample the local cuisine, and choose from a curated selection of the best hotels and places to stay in the city.
Perugia is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out Piazza Iv Novembre, or just taking a stroll in the city center. Soak in the lovely atmosphere and sit down for a bit to eat or drink.
As afternoon approaches, head to your chosen hotel in Perugia. Check-in typically starts around 2 to 4 PM at hotels in Italy. We recommend staying at a hotel in a central location for easy access to the best attractions, restaurants, and bars in the city.
As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Perugia, it's often a good idea to reserve a table in advance.
Enjoy a lovely dining experience at Ristorante Settimo Sigillo, a popular restaurant in Perugia. This acclaimed establishment has earned the admiration of countless food lovers in the city. Alternatively, experience a taste of Perugia at Caffè Baglioni, another great place to eat. With a menu designed to impress, it promises a journey of flavors that will leave you captivated. A third option to check out is the top-rated Bar Pellas. It’s yet another ideal choice to enhance your time in Perugia tonight.
After enjoying a delightful dinner, why not delve into the vibrant local bar scene? You might want to spend the evening at Tommi Bar, a well-loved spot among locals and tourists. Or, head to Valentina. This bar boasts a welcoming environment that is perfect for winding down. You could also continue your night at Caffe Dal Perugino, another top-rated place in the area.
Raise a toast to the start of your 11-day road trip in Italy!
Day 2
- Perugia
- L'Aquila
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Drive 172 km, 2 hours 47 min
- Carducci Gardens
- Porta Marzia
- Rocca Paolina
- National Archaeological Museum of Umbria
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On day 2 of your exciting self-drive vacation in Italy, you’ll soak in the magnificence of 1 destination, Perugia. When you’re not sightseeing, take time to relax at your selected hotel in L'aquila, where you’ll be staying for 1 night.
Perugia is home to plenty of attractions that offer fun adventures, romantic experiences, and scenic views! Start at Carducci Gardens, a beloved park that is worthwhile a visit in the city. Nearby, you’ll find Porta Marzia, enchanting visitors with its breathtaking appeal. Continue your exploration at Rocca Paolina. This historical landmark is one of the city’s most worthwhile spots.
Enjoy the freedom of exploring Perugia at your own pace and find hidden gems along the way. If you want to see more picture-perfect spots, make sure to visit National Archaeological Museum Of Umbria.
At the end of the day, you will drive to L'aquila, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.
After a day of adventure, treat yourself to an exquisite dinner at one of L'aquila's best restaurants.
Get ready for an unforgettable culinary journey in L'aquila by reserving a table at FØRMA contemporary restaurant. Renowned as a Bib Gourmand restaurant, it offers an exceptional contemporary and creative menu. If you're in the mood to try something new, consider DECA, another top spot with a mouthwatering menu.
After your delicious meal, get a taste of the vibrant nightlife with a visit to Art Cafè L'aquila, known for its inviting atmosphere.
Relax and reminisce about your day in Italy and look forward to more memorable moments to come!
Day 3
- L'Aquila
- Naples
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Drive 282 km, 4 hours 5 min
- Palace of Caserta
- Giardini Reali - Parco Reggia di Caserta
- Archaeological Park of Pompeii
- Teatro Grande
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On day 3 of your road trip in Italy, you will get a true taste of the freedom a self-drive vacation in Europe entails. Today’s travel plans include stops at the most scenic, wondrous, and interesting places in Caserta and Pompei. In the evening, you’ll end up in Naples, where you will stay for 2 nights.
Today’s itinerary in L'aquila covers several incredible sights, including a palace, a park, and an archeological site. Start your adventure at Palace Of Caserta. This captivating palace is a place that is appreciated by travelers and locals alike. Next, immerse yourself in the visually striking wonders of Giardini Reali - Parco Reggia Di Caserta, a must-see park in the city.
Consider stopping for a small bite to eat or a drink at a local eatery to keep your energy going. When you’re ready, continue your discovery with a visit to Archaeological Park Of Pompeii. This well-known archeological site offers an enriching experience. For a change of pace, head to Teatro Grande, where you can take in breathtaking features. These sights offer a fulfilling end to a perfect day.
When you’re done exploring for the day, you’ll drive to your hotel in Naples. Check in and spend some time relaxing before you head out to tour the city.
As you explore more of Naples, you'll discover that its culinary landscape is as diverse as its attractions. Whether you're craving traditional dishes bursting with local flavors or innovative creations that push the boundaries of taste, you're sure to find a dining experience that satisfies your cravings.
Experience a taste of local culinary excellence while in Naples by securing a table at Veritas. An esteemed 1-star Michelin restaurant, it features an exceptional campanian and contemporary menu. For an alternative taste experience, visit Il Comandante, famous for its scrumptious creative and mediterranean dishes. This 1-star Michelin venue consistently impresses guests, making it a standout addition to your holiday plans. Looking for another choice? Discover ARIA, a local favorite celebrated for its exquisite contemporary and modern cuisine in Naples. Located in the heart of the city, this 1-star Michelin restaurant is an ideal pick for contemporary and modern cuisine lovers seeking top-notch culinary experiences.
Explore the vibrant nightlife at Happening Cocktail Bar after your meal, a hub for lively evenings and memorable moments. Or, head to Shanti Art Musik Bar for a great selection of flavorful drinks and a charming setting. Furthermore, Gran Caffè Gambrinus is perfect for those looking to extend their night with a touch of local flavor.
Savor another day of unforgettable experiences in Italy!
Day 4
- Naples
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Drive 126 km, 3 hours 36 min
- Amalfi Coast
- Castel Nuovo
- piazza del Plebiscito
- Ovo Castle
- Via Toledo
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Wake up to day 4 of your extraordinary road trip in Italy. With 1 night left in Naples, we encourage you to seize the day and discover the unexplored beauty of the city’s surroundings!
Don’t miss Via Toledo in Amalfi today, a must-see street that offers a glimpse into the village’s vibrant character. Take your time to explore its best features, and enjoy the convenience of nearby top-rated landmarks.
Discover a day packed with fun adventures, breathtaking views, and picturesque spots in Naples. Begin your sightseeing with Amalfi Coast. This top-rated coast is one of the top attractions in the village. Proceed to Castel Nuovo, another must-visit attraction.
As you wander through the inviting streets of Naples, soak in the lively ambiance and take the opportunity to snap some photos. Next, head to Piazza Del Plebiscito. This astonishing public square is a traveler-favorite. Not far away, you’ll find Ovo Castle, another key site on your sightseeing itinerary.
When you’re done exploring for the day, you’ll return to Naples and your accommodation.
Indulge in a memorable dining experience at one of Naples's most popular restaurants, and connect with friendly locals for an authentic adventure.
Make sure to reserve a table at Antica Pizzeria Di Matteo, an iconic dining spot in Naples. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Mercure Napoli Centro Angioino, a popular restaurant in Naples. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of La Lazzara Trattoria e Pizzeria, a hidden gem nestled in Naples. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.
Cap off your culinary experience with a visit to some of the most celebrated bars in the area. For instance, Archivio Storico - Cocktail Bar & Wonderfood stands out as an excellent choice for a post-dinner cocktail. Alternatively, Archeobar offers an ideal atmosphere to enjoy the pleasures of the night. Babette Pub is also a great option that provides a perfect setting for a relaxing evening.
Celebrate another amazing day of your road trip adventure in Italy!
Day 5
- Naples
- Rome
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Drive 241 km, 3 hours 29 min
- St Peter's Basilica
- Sistine Chapel
- Saint Peter's Square
- Vatican Museums
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Experience an unparalleled adventure on day 5 of your road trip in Italy. This exciting part of your journey invites you to discover the renowned landmarks in 1 vibrant destinations - Vatican City. After a day filled with exploration and new experiences, you will retreat to the hotel of your choice in Rome. You will spend 3 nights here for some well-deserved relaxation.
First up is the iconic major basilica, St. Peter's Basilica. Afterward, continue to Sistine Chapel, a chapel every traveler should visit.
As you explore Naples’s charming streets, take in the lively atmosphere and get to know the character of the city. Next, make your way to Saint Peter's Square. This notable square is an essential stop. Following that, head to Vatican Museums, another must-visit site that will enhance your experience.
After soaking up all the sights of today's itinerary, you'll be ready to head in the direction of your accommodation in Rome. Rome offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.
As dinnertime approaches, it's time to head out for a bite to eat in Rome. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.
Treat yourself to an extraordinary dining experience at La Pergola, a 3-star Michelin restaurant offering an incredible mediterranean and contemporary menu. Alternatively, if your taste buds call for something different, Il Pagliaccio is one of the best restaurants for creative and innovative cuisine in Rome. This 2-star Michelin-awardee earns consistently high praises from guests. We also recommend checking out the menu at Enoteca La Torre. As a top-rated establishment with 2 Michelin star, it is an ideal choice for mediterranean and creative cuisine in the city.
Round off your dining experience by visiting La Botticella Of Poggi Giovanni, a prime location for a drink. Alternatively, explore the distinctive characteristics of Almalu Trastevere, a bar catering to every mood and preference. Bar Viminale Di Pepi Maurilio likewise offers a unique atmosphere, perfect for a memorable night out.
Head back to your accommodation in Rome and get some rest in preparation for another magical day of your road trip in Italy!
Day 6
- Rome
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Drive 11 km, 1 hour 19 min
- Castel Sant'Angelo
- Piazza Navona
- Pantheon
- Trevi Fountain
- Villa Borghese
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On day 6 of your road trip, you will have an entire day to explore Rome. You’ll stay in Rome for 2 nights and discover all the best things to see and do in the area.
Whether you prefer a leisurely exploration or a more fast-paced adventure, this itinerary in Rome allows for both. Start by heading to Castel Sant'angelo. This widely recognized castle provides an insightful glimpse into the city's identity. Next, discover Piazza Navona, a visually striking public square, promising a delightful encounter.
Continue your sightseeing with a visit to Pantheon, a world-famous monument. When you’re done, don’t forget to make a stop at the world-famous Trevi Fountain. Round off your day at Villa Borghese, another gem in Rome with eye-catching features to discover.
Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.
After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Rome. Enjoy a satisfying meal that will recharge you for tonight's adventures.
Treat yourself to a delicious dinner at RomAntica, an excellent option for tonight's dining. Looking for something different? Coso Ristorante offers a tantalizing alternative with its diverse menu. And don’t miss DEROMA - Farine Romane. With its reputation for pleasing customers, it’s a fantastic choice for tonight in Rome.
Keep the excitement of the evening going by visiting a bar or two. Sant' Eustachio Caffè is an excellent place to start. You could also check out Yellowsquare Rome, offering a different kind of charm. A last recommendation for the day is Caffè Portofino. This bar promises an enjoyable experience with tasty drinks and a vibrant setting.
Raise your glass to another unforgettable day in Italy!
Day 7
- Rome
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Drive 3 km, 41 min
- Altare della Patria
- Roman Forum
- Colosseum
- Trastevere
- Monti
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Day 7 of your road trip will take you to the best attractions Rome has to offer. Cherish the 1 night you have left in Rome by discovering the best things there are to see and do in the city.
Trastevere is one of the highlights of today. Take your time exploring this iconic neighborhood in Rome, which offers a perfect blend of history and culture. Plus, it's close to many must-see landmarks in the city. Be sure to also visit Monti, a neighborhood that showcases another side of Rome.
Today’s agenda in Rome includes a monument and an archeological site. Altare Della Patria is must-visit monument and a great starting point for the day. Next, continue your journey to Roman Forum, a globally renowned archeological site, located just a leisurely stroll away. Next, head to Colosseum, a historic archeological site, also available for your discovery today.
Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.
After a day of adventure, treat yourself to an exquisite dinner at one of Rome's best restaurants.
Treat yourself to a delightful dinner at Hotel de Russie, highly recommended for tonight's dining. Or, if you're feeling adventurous, why not try La Taverna Italiana? It's another excellent option with a diverse menu. Consider reserving a table at The Parrot Bar as well. Known for its consistent customer satisfaction, it’s an ideal pick for tonight in Rome.
Continue your evening by exploring the vibrant nightlife scene at The Apartment Bar Roma, a prime destination for a thrilling night out. Also, don’t forget to check out Hotel Hassler Roma, a bar that offers unique local touches.
Get a good night's sleep and look forward to another great day on the road in Italy!
Day 8
- Rome
- Siena
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Drive 239 km, 3 hours 11 min
- Piazza di Spagna
- Spanish Steps
- piazza del Popolo
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Dive into day 8 of your remarkable road trip in Italy. Today you will explore Rome, where you will have the opportunity to experience all the top things to see and do. At the end of the day, you’ll unwind at one of the finest accommodations in Siena. You’ll stay here for 2 nights.
Begin your adventure at Piazza Di Spagna. This is a timeless public square you should not miss. Another must-see is Spanish Steps, a spectacular public square in Rome.
When you’re ready for the next sight, head to Piazza Del Popolo.
At the end of the day, you will drive to Siena, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.
After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Siena. Enjoy a satisfying meal that will recharge you for tonight's adventures.
Savor the flavors at Enoteca I Terzi, a top pick for dinner tonight. Alternatively, Ristorante Tar-Tufo beckons with its unique menu offerings. Also, consider Antica Trattoria Papei. With its consistent customer satisfaction, it’s an excellent option for dining in Siena tonight.
Let the evening flow smoothly from dinner to drinks at Meet Life Cafè, a top-rated bar in the area. For other recommendations, Maudit Pub provides a perfect setting for rounding out your night with style and great drinks. Likewise, Bar Impero Siena offers a memorable night with diverse drink options and excellent service.
Say good night to Siena and look forward to another great day of your road trip in Italy!
Day 9
- Siena
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Drive 3 km, 44 min
- Fortezza Medicea
- Loggia del Papa, Siena
- piazza del Campo
- Opera delle Metropolitana
- Siena Cathedral
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Day 9 of your road trip across Italy promises a magnificent time exploring Siena. You have 1 night left in Siena. Take the opportunity to experience more of the best attractions and activities in the city.
A blend of family-friendly attractions, scenic views, and photo-friendly spots await you in Siena on today’s itinerary. First up is the locally appreciated monument, Fortezza Medicea (siena). Afterward, continue to Loggia Del Papa, Siena, a monument every traveler should visit.
As you explore Siena’s charming streets, take in the lively atmosphere and get to know the character of the city. Next, make your way to Piazza Del Campo. This famous public square is an essential stop. Following that, head to Opera Delle Metropolitana, another must-visit site that will enhance your experience. Don’t forget to stop by Siena Cathedral, a locally renowned church in the city.
Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.
As dinnertime approaches, it's time to head out for a bite to eat in Siena. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.
Make sure to reserve a table at Osteria Quattro Venti, an iconic dining spot in Siena. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Fischi per Fiaschi, a popular restaurant in Siena. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of Osteria da Divo, a hidden gem nestled in Siena. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.
Continue your lively evening at Charlie Mixology Bar Di Aldinucci Riccardo, a perfect place for winding down or revving up the night, depending on which mood you’re in. Bar Pinacoteca is another excellent bar that offers a great selection of drinks to suit any mood. If you prefer to go somewhere else, San Paolo Pub ensures a night out tailored to your taste.
Take some time to reflect on your day and savor another beautiful night in Italy.
Day 10
- Siena
- Perugia
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Drive 156 km, 2 hours 38 min
- Basilica of San Francesco d'Assisi
- Cathedral of San Rufino
- Basilica di Santa Chiara
- Basilica of Santa Maria degli Angeli
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Embark on another extraordinary experience on day 10 of your road trip in Italy. Today, you will make 1 stop and experience some of the highlights of Santa Maria degli Angeli. At the end of the day, you will enjoy the comforts of a top-rated hotel in Perugia, which will be your home away from home for 1 night.
Discover a day packed with family-friendly attractions, scenic views, and picturesque spots in Siena. Begin your sightseeing with Basilica Of San Francesco D'assisi. This well-known church is one of the top attractions in the town. Proceed to Cathedral Of San Rufino, another must-visit attraction.
As you wander through the inviting streets of Siena, soak in the lively ambiance and take the opportunity to snap some photos. Next, head to Basilica Di Santa Chiara. This up-and-coming church is a traveler-favorite. Not far away, you’ll find Basilica Of Santa Maria Degli Angeli, another key site on your sightseeing itinerary.
When you’re done exploring for the day, you’ll drive to your hotel in Perugia. Check in and spend some time relaxing before you head out to tour the city.
As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Perugia. Enjoy a relaxing evening as you savor delicious local cuisine and reflect on the day's adventures.
Enjoy a lovely dining experience at La Taverna, a popular restaurant in Perugia. This acclaimed establishment has earned the admiration of countless food lovers in the city. Alternatively, experience a taste of Perugia at Ristorante del Sole, another great place to eat. With a menu designed to impress, it promises a journey of flavors that will leave you captivated. A third option to check out is the top-rated Al Mangiar Bene. It’s yet another ideal choice to enhance your time in Perugia tonight.
Keep the evening going at Caffè Fortebraccio, a great choice for enjoying the after-dinner hours with a drink. You could also go to Caffe Del Banco, which offers a similarly pleasant setting and great drinks. Another option is Dempsey's Perugia, which provides an inviting environment for unwinding after a busy day out.
As the day draws to a close, take a moment to unwind and prepare for the next exciting chapter of your road trip in in Italy.
Day 11
- Perugia - Departure day
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- Etruscan Arch
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Day 11 of your road trip in Italy is your departure day. This is your chance to catch a last glimpse of Perugia before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.
If you're up for some more sightseeing, we recommend visiting Etruscan Arch, a standout historical landmark before you head out.
Explore local shops for souvenirs to remember your trip or find unique gifts for loved ones.
Before you conclude your road trip in Italy, drop by another restaurant for a last chance at a memorable dining experience in Perugia.
You’ll then say farewell to Perugia. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Italy!
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