12-Day Italy Self-Drive Road Trip With Itinerary from Ancona to Florence, Lucca, Siena, Rome, and Santa Maria degli Angeli

Dive into day 2 of your remarkable road trip in Italy. Today you'll explore 1 destination, including Florence. At the end of the day, you’ll unwind at one of the finest accommodations in Florence, where you'll spend 2 nights.

Florence’s wonders await as you prepare for another journey on the road, leaving the breathtaking surroundings of Ancona behind. This drive usually takes around 3 hours 24 min. Florence welcomes you with a multitude of unique vacation experiences.

For a more meaningful self-guided tour of the city's best attractions, visit Ponte Vecchio, a wondrous historical landmark that is sure to impress. Take in the surroundings and enjoy the freedom of exploring at your own pace before you continue your journey. Next, head to Uffizi Gallery and admire its romantic features.

When you’re ready, continue to Palazzo Vecchio, an interesting palace beloved by locals and tourists alike. Don't miss out on Loggia Dei Lanzi, another highlight of the area that promises a memorable visit. Not far away, you’ll also find Piazza Della Signoria, a history-steeped place to see that you won’t regret spending some extra time discovering.

At the end of the day, you will drive to Florence, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Florence. Enjoy a relaxing evening as you savor delicious local cuisine.

Treat yourself to a delightful dinner at Ristorante Oliviero 1962, highly recommended for tonight's dining. Or, if you're feeling adventurous, why not try Di Poneta Novoli? It's another excellent option with a diverse menu. Consider reserving a table at Caffe San Firenze as well. Known for its consistent customer satisfaction, it’s an ideal pick for tonight in Florence.

After your delicious meal, get a taste of the vibrant nightlife with a visit to Manifattura, known for its inviting atmosphere. Se·sto On Arno Rooftop Bar is another great option if you’re looking for a place to get the night started. Similarly, Il Vinile provides a great setting to enjoy the night away.

Take some time to reflect on your day and savor another beautiful night in Italy.

Day 3 of your road trip across Italy promises a magnificent time exploring what to see in Florence. You have 1 night left in Florence. Take the opportunity to experience more of the best attractions and activities in the city.

Catch David before the crowds roll in. Next, dive into the noteworthy features of Galleria Dell'accademia, a must-visit art gallery in the city.

In between sights, stop by local stores, picturesque photo spots, and small eateries. When you’re ready for your next attraction, proceed to Cathedral Of Santa Maria Del Fiore, an astonishing church. For a change of scene, check out Museo Dell'opera Del Duomo, known for its heritage-rich features. We also recommend visiting Basilica Of Santa Croce In Florence. This church is a must for anyone looking to experience the city to the fullest. Lastly, end your day with a visit to Piazzale Michelangelo, yet another top-rated attraction in Florence.

Don’t forget to check out all the popular tours and experiences you can add to your travel plans in Italy. You can explore and select activities under each day of your itinerary.

Indulge in a memorable dining experience at one of Florence's most popular restaurants, and connect with friendly locals for a true cultural experience.

Enjoy a delicious meal at Ditta Artigianale, a highly-rated dining destination in Florence. If you're eager to try something different, consider Trattoria Da Burde, another top spot with a tantalizing menu. You might also want to secure a reservation at Casa Toscana. With a reputation for consistently satisfying customers, it’s an excellent choice to enhance your stay in Florence this evening.

Keep the excitement of the evening going by visiting a bar or two. Bar 50 Rosso is an excellent place to start. You could also check out Bitter Bar, offering a different kind of charm. A last recommendation for the day is Archea Brewery. This bar promises an enjoyable experience with tasty drinks and a vibrant setting.

Take some time to reflect on your day and savor another beautiful night in Italy.

On day 4 of your exciting self-drive vacation in Italy, you’ll soak in the magnificence of 1 destination, including Pisa. When you’re not sightseeing, take time to relax at your chosen hotel in Lucca, where you’ll be staying for 2 nights.

Throughout the day, make sure to take breaks to appreciate the surroundings.

Fasten your seatbelt and make your way to your next stop — Pisa, home to many well-known sights in the region. Keep in mind that your travel time from Florence to Pisa may take around 1 hour 18 min without traffic disruptions. Upon arrival in Pisa, we highly recommend checking out some of the top attractions.

Savor the day by heading to Leaning Tower Of Pisa, a globally renowned monument that draws visitors from near and far.

Next, explore Pisa Cathedral, yet another worthwhile place to see in the area. After the church, make time to go to Piazza Del Duomo, Pisa. This stunning public square is well worth the visit. Lastly, head to Cittadella Nuova, an increasingly popular park you won’t want to miss.

When you’re done exploring for the day, you’ll drive to your hotel in Lucca. Check in and relax before you head out to tour the city.

After a day of adventure, treat yourself to an exquisite dinner at one of Lucca's best restaurants.

Enjoy a lovely dining experience at Gli Orti di Via Elisa, a popular restaurant in Lucca. This acclaimed establishment has earned the admiration of countless food lovers in the city. Alternatively, experience a taste of Lucca at Bar Caffè Ristretto, another great place to eat. With a menu designed to impress, it promises a journey of flavors that will leave you captivated. A third option to check out is the top-rated Ristorante Schiaffino. It’s yet another ideal choice to enhance your time in Lucca tonight.

If you’re not ready to end the night just yet, Lebowski - Cocktail Bar offers a perfect venue to relax and savor a drink. Similarly, Blend is well-suited for those looking to unwind in a social setting. Franklin'33 is another excellent spot to enjoy a nightcap after a delightful meal.

Get a good night's sleep and look forward to another great day on the road in Italy!

On day 5 of your road trip, you will have an entire day to discover what to see in Lucca. You’ll stay in Lucca for 1 night.

Make a stop at Piazza Dell'anfiteatro. This captivating public square is a must-visit for travelers looking for a unique holiday experience. Make your way to Guinigi Tower located in Lucca for another exciting encounter.

Next, immerse yourself in the setting of St Martin Cathedral. Its breathtaking features will captivate you. After the church, continue your tour of the city with a visit to Palazzo Ducale Di Lucca. Visitors usually appreciate the romantic features of this palace. Next up is Mura Di Lucca, a highly recommended historical landmark. For a change of pace, head to Parrocchia Di San Concordio. As one of the most curiosity-inducing attractions in Lucca, this church is the perfect place to end your self-guided sightseeing tour.

Don’t forget to check out all the popular tours and experiences you can add to your travel plans in Italy. You can explore and select activities under each day of your itinerary.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Lucca, it's often a good idea to reserve a table in advance.

Don’t miss out on dining at Osteria Nova, a top-rated dining destination in Lucca. If you're in the mood to try something new, consider La Bottega di Anna e Leo, another top spot with a mouthwatering menu. You might also want to secure a reservation at Ristorante Per 21. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Lucca this evening.

To truly maximize your evening out, consider visiting La Tana Del Boia after dinner. This bar is known for offering some of the best drinks and vibes in the city. Alternatively, head to Vinarkia Della Pavona - Cocktail Bar, another bar with an inviting ambiance. Similarly, Magellano also offers a great atmosphere, ensuring a night filled with enjoyment and relaxation.

Relax and recharge in preparation for another adventurous day in Italy!

Day 7 offers an itinerary packed with the best things to see in Ancona. You’ll stay in Siena for 1 night more, offering you enough time to explore at a relaxed pace.

Let Pinacoteca Nazionale set the tone for the day. Spend some time admiring this standout art gallery before continuing your journey. Musei Dell’accademia Dei Fisiocritici is your next stop. This underrated museum is one of the best-rated sights in Siena.

Consider grabbing some lunch or a light snack to keep your energy going. Beyond the above-mentioned attractions, today is also the perfect time to visit Porta Tufi. This historic historical landmark is a sight to behold.

Don’t forget to check out all the popular tours and experiences you can add to your travel plans in Italy. You can explore and select activities under each day of your itinerary.

After a day of adventure, treat yourself to an exquisite dinner at one of Siena's best restaurants.

Treat yourself to a wonderful meal at Osteria Quattro Venti, a top-rated dining spot in Siena. If you're in the mood for something new, try Fischi per Fiaschi, another premier location with a delectable menu. You might also want to book a table at Osteria da Divo. Known for its consistently satisfied patrons, it’s a perfect choice to elevate your evening in Siena.

Explore the vibrant nightlife at Charlie Mixology Bar Di Aldinucci Riccardo after your meal, a hub for lively evenings and memorable moments. Or, head to Bar Pinacoteca for a great selection of flavorful drinks and a charming setting. Furthermore, San Paolo Pub is perfect for those looking to extend their night with a touch of local flavor.

Relax and look forward to more memorable moments to come!

Experience an unparalleled adventure on day 8 of your road trip in Italy. This exciting part of your journey invites you to discover the renowned landmarks in 1 place, which are Rome. At the end of the day, you will retreat to the hotel of your choice in Rome, where will spend 2 nights.

When you’ve had your share of Siena, prepare for your next destination. Admire the views and listen to some good music as you drive in the direction of Rome. Your travel time is around 2 hours 42 min.

Set out on a self-guided sightseeing tour at Colosseum and explore the picture-perfect features. Next, make your way to Roman Forum, another highlight in Rome. When you’re done exploring the archeological site, continue to Trevi Fountain, a history-steeped monument.

Nearby, you will also find Pantheon. This wondrous monument is a top place to see in the area. Lastly, head to Piazza Navona, a visually striking public square that is perfect for some final exploring in the city.

At the end of the day, you will drive to Rome, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

Indulge in a memorable dining experience at one of Rome's most popular restaurants, and connect with friendly locals for a true cultural experience.

Don’t miss out on dining at La Bottega Roma, a top-rated dining destination in Rome. If you're in the mood to try something new, consider Pasta In Corso, another top spot with a mouthwatering menu. You might also want to secure a reservation at Trattoria Vecchia Roma. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Rome this evening.

Extend your evening after a delightful meal by visiting La Botticella Of Poggi Giovanni, which offers the perfect atmosphere for a night out. Moreover, Almalu Trastevere is another popular option for a drink or two. Likewise, Bar Viminale Di Pepi Maurilio also provides a great ambiance for reminiscing about the day and raising a toast to your vacation.

Celebrate another amazing day of your road trip adventure in Italy!

On day 9 of your road trip, you’ll start and end your day in Rome, where you still have 1 night left. You'll spend part of the day exploring places of interest outside the immediate city, including Vatican City.

Set aside time today to explore Trastevere, a standout neighborhood that reflects the essence of the city. While you're there, you'll also be within reach of some of the city's top landmarks, making it easy to maximize your day. You might also want to visit Monti, a neighborhood offering another perspective on the city.

Admire the views and listen to some good music as you drive in the direction of Vatican City.

For a more meaningful self-guided tour of the city's best attractions, visit Vatican Museums, a timeless art museum that is sure to impress. Take in the surroundings and enjoy the freedom of exploring at your own pace before you continue your journey.

When you’re ready, continue to St. Peter's Basilica, a world-famous major basilica beloved by locals and tourists alike.

When you’re done exploring the area’s best attractions, you’ll drive back to your accommodation in Rome.

Rome is a place where the culinary landscape is as diverse as its attractions. So before the day ends, treat your palate to a taste of local cuisine at one of the best restaurants in Rome.

Treat yourself to a delightful dinner at RomAntica, highly recommended for tonight's dining. Or, if you're feeling adventurous, why not try Coso Ristorante? It's another excellent option with a diverse menu. Consider reserving a table at DEROMA - Farine Romane as well. Known for its consistent customer satisfaction, it’s an ideal pick for tonight in Rome.

Unwind after your meal by stepping into Sant' Eustachio Caffè. This venue is celebrated for its extensive drink selections and cozy vibes. Alternatively, Yellowsquare Rome offers a dynamic and energetic atmosphere for a glass or two. Don’t overlook Caffè Portofino, another top-rated bar in the area.

Relax and recharge in preparation for another adventurous day in Italy!

Your itinerary for day 10 of your road trip in Italy includes 1 stop and features some of the highlights of Santa Maria degli Angeli. At the end of the day, enjoy the comforts of a top-rated hotel in Santa Maria degli Angeli, where you'll spend 1 night.

When you’re ready to jump back into the car and say goodbye to Rome, you’ll hit the road in the direction of Santa Maria degli Angeli. This drive usually takes around 2 hours 25 min.

Our first attraction recommendation in Santa Maria degli Angeli is Basilica Of San Francesco D'assisi, a captivating church that draws attention for its majestic features. Spend some time soaking in the atmosphere before continuing to Rocca Maggiore, a grand castle that stands out in the town.

Time flies when you're having fun! But don't forget to stop for a bit to eat and drink between your adventures. When you're rested and recharged, head to Piazza Del Comune, an intriguing public square that offers a unique experience. Be sure to also explore Church Of Santa Maria Sopra Minerva In Assisi, a nearby church, highly recommended by other travelers.

When you’re done exploring for the day, you’ll drive to your hotel in Santa Maria degli Angeli. Check in and relax before you head out to tour the town.

Santa Maria degli Angeli is a place where the culinary landscape is as diverse as its attractions. So before the day ends, treat your palate to a taste of local cuisine at one of the best restaurants in Santa Maria degli Angeli.

After your meal, keep the night alive at a bar like Bibenda Assisi Wine Tasting & Gourmet Food, Olive Oil And Chocolate Tastings, known for its lively atmosphere.

Relax and look forward to more memorable moments to come!