12-Day Italy Self-Drive Road Trip With Itinerary from Ancona to Florence, Lucca, Siena, Rome, and Santa Maria degli Angeli

Experience an unparalleled adventure on day 2 of your road trip in Italy. This exciting part of your journey invites you to discover the renowned landmarks in 1 vibrant destinations - Florence. After a day filled with exploration and new experiences, you will retreat to the hotel of your choice in Florence. You will spend 2 nights here for some well-deserved relaxation.

Savor the day by visiting some of the best places to see in Ancona, including a historical landmark, an art gallery, a palace, a public square and much more! Start your adventure at Ponte Vecchio. This globally renowned historical landmark is a must-visit for travelers looking for a unique holiday experience. Make your way to Uffizi Gallery located in Ancona for another exciting encounter.

Next, immerse yourself in the setting of Palazzo Vecchio. Its symbolic features will captivate you. After the palace, continue your tour of the city with a visit to Loggia Dei Lanzi. Visitors usually appreciate the history-steeped features of this public square. Next up is Piazza Della Signoria, a highly recommended public square.

After soaking up all the sights of today's itinerary, you'll be ready to head in the direction of your accommodation in Florence. Florence offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

As you explore more of Florence, you'll discover that its culinary landscape is as diverse as its attractions. Whether you're craving traditional dishes bursting with local flavors or innovative creations that push the boundaries of taste, you're sure to find a dining experience that satisfies your cravings.

Make sure to reserve a table at Ristorante Oliviero 1962, an iconic dining spot in Florence. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Di Poneta Novoli, a popular restaurant in Florence. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of Caffe San Firenze, a hidden gem nestled in Florence. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

Cap off your dinner by heading to Manifattura, ideal for a leisurely evening with a drink in hand. Se·sto On Arno Rooftop Bar is another bar that offers an enjoyable setting. Similarly, Il Vinile is also a popular place to go on a night out, perfect for relaxing and socializing.

Get a good night's sleep and look forward to another great day on the road in Italy!

Day 3 of your road trip across Italy promises a magnificent time exploring Florence. You have 1 night left in Florence. Take the opportunity to experience more of the best attractions and activities in the city.

Enjoy the perfect balance of relaxation and exploration in Florence today. One of the most interesting attractions included on the itinerary is David. Then, take a leisurely stroll to Galleria Dell'accademia and learn what makes this detailed art gallery unique.

Throughout the day, make sure to take breaks to appreciate the surroundings. Next up, visit the impressive Cathedral Of Santa Maria Del Fiore. After exploring the church, head to Museo Dell'opera Del Duomo. This often recommended museum is a highlight in Florence. As your day continues, stop by Basilica Of Santa Croce In Florence, known for its culturally significant features. Lastly, don’t forget to check out the spectacular Piazzale Michelangelo. Enjoy exploring this incredible observation deck at your own pace.

Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Florence. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Make sure to reserve a table at Ditta Artigianale, an iconic dining spot in Florence. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Trattoria Da Burde, a popular restaurant in Florence. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of Casa Toscana, a hidden gem nestled in Florence. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

Keep the evening going at Bar 50 Rosso, a great choice for enjoying the after-dinner hours with a drink. You could also go to Bitter Bar, which offers a similarly pleasant setting and great drinks. Another option is Archea Brewery, which provides an inviting environment for unwinding after a busy day out.

As the day draws to a close, take a moment to unwind and prepare for the next exciting chapter of your road trip in in Italy.

On day 4 of your exciting self-drive vacation in Italy, you’ll soak in the magnificence of 1 destination, Pisa. When you’re not sightseeing, take time to relax at your selected hotel in Lucca, where you’ll be staying for 2 nights.

Get ready for a day filled with family-friendly attractions, breathtaking views, and picturesque spots in the charming city of Florence. Your adventure starts at Leaning Tower Of Pisa, a globally renowned local hot spot. Another notable attraction to explore is Angelo Caduto. This up-and-coming sightseeing destination is known for its picture-perfect appeal.

After soaking in the highlights of these sights, take some time to wander Florence's streets and immerse yourself in the local atmosphere. When you're ready to continue your sightseeing adventure, head to Pisa Cathedral. This UNESCO world heritage-designated church offers a fascinating experience that many visitors find memorable. Piazza Del Duomo, Pisa is also worth visiting, along with Cittadella Nuova. These standout landmarks offer unique experiences that add to the day’s enjoyment.

At the end of the day, you will drive to Lucca, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

After a day of adventure, treat yourself to an exquisite dinner at one of Lucca's best restaurants.

Don’t miss out on dining at Gli Orti di Via Elisa, a top-rated dining destination in Lucca. If you're in the mood to try something new, consider Bar Caffè Ristretto, another top spot with a mouthwatering menu. You might also want to secure a reservation at Ristorante Schiaffino. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Lucca this evening.

To truly maximize your evening out, consider visiting Lebowski - Cocktail Bar after dinner. This bar is known for offering some of the best drinks and vibes in the city. Alternatively, head to Blend, another bar with an inviting ambiance. Similarly, Franklin'33 also offers a great atmosphere, ensuring a night filled with enjoyment and relaxation.

Raise your glass to another unforgettable day in Italy!

Day 5 offers a multitude of experiences. You will stay in Lucca for 1 night more, offering you enough time to explore at a relaxed pace.

Set out on a day brimming with fun adventures, romantic experiences, and breathtaking views. Start at the interesting Piazza Dell'anfiteatro, an awe-inspiring public square in Lucca. Next, go to Guinigi Tower.

After visiting Piazza Dell'anfiteatro and Guinigi Tower, have a stroll along Lucca's streets and take in the local charm. Continue your sightseeing by heading to St Martin Cathedral. This monumental church offers a unique experience. Palazzo Ducale Di Lucca is another noteworthy attraction worthwhile a visit. End your self-guided sightseeing tour on top with a visit to Mura Di Lucca, one of the most history-steeped places to visit in Lucca. If you still have some time left for sightseeing, we also recommend stopping by Parrocchia Di San Concordio.

Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.

Indulge in a memorable dining experience at one of Lucca's most popular restaurants, and connect with friendly locals for an authentic adventure.

Enjoy a delicious meal at Osteria Nova, a top-rated dining destination in Lucca. If you're in the mood to try something new, consider La Bottega di Anna e Leo, another top spot with a mouthwatering menu. You might also want to secure a reservation at Ristorante Per 21. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Lucca this evening.

Keep the excitement of the evening going by visiting a bar or two. La Tana Del Boia is an excellent place to start. You could also check out Vinarkia Della Pavona - Cocktail Bar, offering a different kind of charm. A last recommendation for the day is Magellano. This bar promises an enjoyable experience with tasty drinks and a vibrant setting.

Get a good night's sleep and look forward to another great day on the road in Italy!

Day 7 of your road trip will take you to the best attractions Siena has to offer. Cherish the 1 night you have left in Siena by discovering the best things there are to see and do in the city.

Whether you prefer a leisurely exploration or a more fast-paced adventure, this itinerary in Siena allows for both. Start by heading to Pinacoteca Nazionale. This curiosity-inducing art gallery provides an insightful glimpse into the city's identity. Next, discover Musei Dell’accademia Dei Fisiocritici, a heritage-rich museum, promising a delightful encounter.

Continue your sightseeing with a visit to Porta Tufi, an underrated historical landmark.

Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.

After a day of adventure, treat yourself to an exquisite dinner at one of Siena's best restaurants.

Savor the flavors at Osteria Quattro Venti, a top pick for dinner tonight. Alternatively, Fischi per Fiaschi beckons with its unique menu offerings. Also, consider Osteria da Divo. With its consistent customer satisfaction, it’s an excellent option for dining in Siena tonight.

Following your dinner, dive into the local bar culture at Charlie Mixology Bar Di Aldinucci Riccardo. Enjoy this evening's relaxed ambiance with delightful drinks. Alternatively, go to Bar Pinacoteca, the perfect place for those looking to experience the best of the nightlife. Similarly, San Paolo Pub provides excellent drinks and a great atmosphere, ensuring a memorable night out.

Take some time to reflect on your day and savor another beautiful night in Italy.

On day 8 of your road trip in Italy, you will get a true taste of the freedom a self-drive vacation in Europe entails. Today’s travel plans include stops at the most scenic, wondrous, and interesting places in Rome. In the evening, you’ll end up in Rome, where you will stay for 2 nights.

Get ready to discover some of the most iconic wonders in Siena, including an archeological site, a monument, and a public square. Start your day at Colosseum. This UNESCO world heritage-designated archeological site is an iconic place to see in Siena. Then, wander over to Roman Forum. If culturally significant sites excite you, this archeological site will be right up your alley. Nearby, you’ll also find Trevi Fountain. This visually striking monument is a favorite among visitors.

Siena offers plenty to explore, ensuring every moment of your visit is filled with excitement and discovery. If you're up for more, Pantheon is a timeless spot in the city that will captivate you with its unique charm. When you’re done at the monument, don’t forget to check out the enchanting Piazza Navona. Take a moment to appreciate the fascinating details of this globally renowned public square.

After soaking up all the sights of today's itinerary, you'll be ready to head in the direction of your accommodation in Rome. Rome offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

As dinnertime approaches, it's time to head out for a bite to eat in Rome. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.

Treat yourself to a delicious dinner at La Bottega Roma, an excellent option for tonight's dining. Looking for something different? Pasta In Corso offers a tantalizing alternative with its diverse menu. And don’t miss Trattoria Vecchia Roma. With its reputation for pleasing customers, it’s a fantastic choice for tonight in Rome.

After enjoying a delightful dinner, why not delve into the vibrant local bar scene? You might want to spend the evening at La Botticella Of Poggi Giovanni, a well-loved spot among locals and tourists. Or, head to Almalu Trastevere. This bar boasts a welcoming environment that is perfect for winding down. You could also continue your night at Bar Viminale Di Pepi Maurilio, another top-rated place in the area.

Say good night to Rome and look forward to another great day of your road trip in Italy!

On day 9 of your road trip, you’ll start and end your day in Rome, but spend part of the day exploring places of interest outside the immediate city. On today's itinerary, you'll find attractions in Vatican City. You still have 1 night left in Rome.

A visit to Trastevere in Vatican City is a must on the agenda today. This neighborhood is full of hidden gems and character, perfect for a leisurely stroll. Plus, you’ll be close to some of the city’s most famous sights. Don’t forget to check out Monti as well, a neighborhood that adds another layer to your exploration.

Bring your curiosity for today’s adventure around Rome. Some of the city’s most loved attractions await! Vatican Museums is the perfect place to start. This art museum is one of the most timeless places to visit in Rome.

Visit these for an interesting touch to your journey.

When you’re done exploring the area’s best attractions, you’ll drive back to your accommodation in Rome.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Rome. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Dine in style at RomAntica, a top recommendation for dinner tonight. Or, for a change of pace, Coso Ristorante boasts a menu that's sure to impress. Also, be sure to check out DEROMA - Farine Romane. Known as a local hotspot, it’s a great choice for tonight in Rome.

Cap off your dinner by heading to Sant' Eustachio Caffè, ideal for a leisurely evening with a drink in hand. Yellowsquare Rome is another bar that offers an enjoyable setting. Similarly, Caffè Portofino is also a popular place to go on a night out, perfect for relaxing and socializing.

As the day draws to a close, take a moment to unwind and prepare for the next exciting chapter of your road trip in in Italy.

Dive into day 10 of your remarkable road trip in Italy. Today you will explore Santa Maria degli Angeli, where you will have the opportunity to experience all the top things to see and do. At the end of the day, you’ll unwind at one of the finest accommodations in Santa Maria degli Angeli. You’ll stay here for 1 night.

Enjoy the perfect balance of relaxation and exploration in Rome today. One of the most popular attractions included on the itinerary is Basilica Of San Francesco D'assisi. This picture-perfect church will help you start your sightseeing on top. Then, take a leisurely stroll to Rocca Maggiore and learn what makes this enchanting castle unique.

Throughout the day, make sure to take breaks to appreciate the surroundings. Next up, visit the up-and-coming Piazza Del Comune. After exploring the public square, head to Church Of Santa Maria Sopra Minerva In Assisi. This up-and-coming church is a highlight in Rome.

At the end of the day, you will drive to Santa Maria degli Angeli, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

Indulge in a memorable dining experience at one of Santa Maria degli Angeli's most popular restaurants, and connect with friendly locals for an authentic adventure.

Extend your evening after a delightful meal by visiting Bibenda Assisi Wine Tasting & Gourmet Food, Olive Oil And Chocolate Tastings, which offers the perfect atmosphere for a night out.

Savor another day of unforgettable experiences in Italy!