12-Day Italy Self-Drive Road Trip With Itinerary from Ancona to Florence, Lucca, Siena, Rome, and Santa Maria degli Angeli

Embark on another extraordinary experience on day 2 of your road trip in Italy. Today, you will make 1 stop and experience some of the highlights of Florence. At the end of the day, you will enjoy the comforts of a top-rated hotel in Florence, which will be your home away from home for 2 nights.

Set out on a day brimming with family-friendly attractions, romantic experiences, and scenic views. Start at the world-famous Ponte Vecchio, a romantic historical landmark in Ancona. Next, go to Uffizi Gallery.

After visiting Ponte Vecchio and Uffizi Gallery, have a stroll along Ancona's streets and take in the local charm. Continue your sightseeing by heading to Palazzo Vecchio. This romantic palace offers a unique experience. Loggia Dei Lanzi is another noteworthy attraction worthwhile a visit. End your self-guided sightseeing tour on top with a visit to Piazza Della Signoria, one of the most enchanting places to visit in Ancona.

After soaking up all the sights of today's itinerary, you'll be ready to head in the direction of your accommodation in Florence. Florence offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

As dinnertime approaches, it's time to head out for a bite to eat in Florence. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.

Dine in style at Ristorante Oliviero 1962, a top recommendation for dinner tonight. Or, for a change of pace, Di Poneta Novoli boasts a menu that's sure to impress. Also, be sure to check out Caffe San Firenze. Known as a local hotspot, it’s a great choice for tonight in Florence.

Cap off your culinary experience with a visit to some of the most celebrated bars in the area. For instance, Manifattura stands out as an excellent choice for a post-dinner cocktail. Alternatively, Se·sto On Arno Rooftop Bar offers an ideal atmosphere to enjoy the pleasures of the night. Il Vinile is also a great option that provides a perfect setting for a relaxing evening.

Say good night to Florence and look forward to another great day of your road trip in Italy!

Day 3 of your road trip across Italy promises a magnificent time exploring Florence. You have 1 night left in Florence. Take the opportunity to experience more of the best attractions and activities in the city.

Start your adventure at David. This well-known statue is a must-visit for travelers looking for a unique holiday experience. Make your way to Galleria Dell'accademia located in Florence for another exciting encounter.

Next, immerse yourself in the setting of Cathedral Of Santa Maria Del Fiore. Its inviting features will captivate you. After the church, continue your tour of the city with a visit to Museo Dell'opera Del Duomo. Visitors usually appreciate the heritage-rich features of this museum. Next up is Basilica Of Santa Croce In Florence, a highly recommended church. For a change of pace, head to Piazzale Michelangelo. As one of the most top-rated attractions in Florence, this observation deck is the perfect place to end your self-guided sightseeing tour.

Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.

As you explore more of Florence, you'll discover that its culinary landscape is as diverse as its attractions. Whether you're craving traditional dishes bursting with local flavors or innovative creations that push the boundaries of taste, you're sure to find a dining experience that satisfies your cravings.

Treat yourself to a wonderful meal at Ditta Artigianale, a top-rated dining spot in Florence. If you're in the mood for something new, try Trattoria Da Burde, another premier location with a delectable menu. You might also want to book a table at Casa Toscana. Known for its consistently satisfied patrons, it’s a perfect choice to elevate your evening in Florence.

After savoring a delicious meal, step into the vibrant nightlife at Bar 50 Rosso, where the evening is just getting started. In the same way, Bitter Bar offers a unique charm perfect for experiencing the local bar scene in Florence. Archea Brewery is another top-recommended bar that is sure to get you into the mood for some dancing and celebrating.

As the sun sets on another day of adventure, rest up and recharge for the next leg of your road trip in Italy.

On day 4 of your road trip in Italy, you will get a true taste of the freedom a self-drive vacation in Europe entails. Today’s travel plans include stops at the most scenic, wondrous, and interesting places in Pisa. In the evening, you’ll end up in Lucca, where you will stay for 2 nights.

Start by visiting Leaning Tower Of Pisa, a prime spot to begin your journey. This UNESCO world heritage-designated monument is sure to impress.

While exploring and sightseeing, take time to savor the culture of Florence by sampling some local delicacies. When you’re ready for more sightseeing, head to Pisa Cathedral. This breathtaking church is an essential place to visit for anyone looking for the full Florence experience. We also recommend visiting Piazza Del Duomo, Pisa, a globally renowned public square. Nearby, you'll also find Cittadella Nuova, ready to add charm to your journey.

At the end of the day, you will drive to Lucca, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

As you explore more of Lucca, you'll discover that its culinary landscape is as diverse as its attractions. Whether you're craving traditional dishes bursting with local flavors or innovative creations that push the boundaries of taste, you're sure to find a dining experience that satisfies your cravings.

Enjoy a lovely meal at Gli Orti di Via Elisa, a top-rated place to have dinner tonight. Alternatively, if your taste buds call for something different, Bar Caffè Ristretto is another top choice with a popular menu. You could also check for a table at Ristorante Schiaffino. As an establishment that gains consistently high praises from customers, it’s an ideal choice in Lucca tonight.

After your meal, keep the night alive at a bar like Lebowski - Cocktail Bar, known for its lively atmosphere. Blend is another top recommendation that provides the perfect setting with well-crafted drinks and a welcoming ambiance. Similarly, Franklin'33 offers an excellent atmosphere for those looking to amp up the evening.

Relax and reminisce about your day in Italy and look forward to more memorable moments to come!

Day 5 offers a multitude of experiences. You will stay in Lucca for 1 night more, offering you enough time to explore at a relaxed pace.

Lucca is home to plenty of attractions that offer family-friendly attractions, romantic experiences, and breathtaking views! Start at Piazza Dell'anfiteatro, a well-known public square that is worthwhile a visit in the city. Nearby, you’ll find Guinigi Tower, enchanting visitors with its enchanting appeal. Continue your exploration at St Martin Cathedral. This church is one of the city’s most locally appreciated spots.

Enjoy the freedom of exploring Lucca at your own pace and find hidden gems along the way. If you want to see more picture-perfect spots, make sure to visit Palazzo Ducale Di Lucca. After exploring the palace, head to the underrated Mura Di Lucca. Lastly, wrap up today’s self-guided sightseeing tour with a visit to Parrocchia Di San Concordio, a place of heritage-rich interest in Lucca.

Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.

As dinnertime approaches, it's time to head out for a bite to eat in Lucca. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.

Make sure to reserve a table at Osteria Nova, an iconic dining spot in Lucca. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of La Bottega di Anna e Leo, a popular restaurant in Lucca. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of Ristorante Per 21, a hidden gem nestled in Lucca. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

Continue your evening by exploring the vibrant nightlife scene at La Tana Del Boia, a prime destination for a thrilling night out. Also, don’t forget to check out Vinarkia Della Pavona - Cocktail Bar, a bar that offers unique local touches. Likewise, Magellano provides an excellent alternative for a fun evening.

Raise your glass and celebrate another amazing day of your road trip in Italy!

Day 7 of your road trip will take you to the best attractions Siena has to offer. Cherish the 1 night you have left in Siena by discovering the best things there are to see and do in the city.

Prepare for a day full of fun adventures, photo-friendly spots, and historic treasures. When you’re ready, kick off your sightseeing adventure at Pinacoteca Nazionale. This up-and-coming art gallery is a must-visit for anyone seeking a unique vacation experience. Another sight you shouldn’t miss is Musei Dell’accademia Dei Fisiocritici, one of the city’s best highlights.

Next, check out Porta Tufi, one of the most often recommended places to see in Siena. This historical landmark is a favorite among locals and travelers alike.

Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.

After a day of adventure, treat yourself to an exquisite dinner at one of Siena's best restaurants.

Don’t miss out on dining at Osteria Quattro Venti, a top-rated dining destination in Siena. If you're in the mood to try something new, consider Fischi per Fiaschi, another top spot with a mouthwatering menu. You might also want to secure a reservation at Osteria da Divo. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Siena this evening.

Keep the excitement of the evening going by visiting a bar or two. Charlie Mixology Bar Di Aldinucci Riccardo is an excellent place to start. You could also check out Bar Pinacoteca, offering a different kind of charm. A last recommendation for the day is San Paolo Pub. This bar promises an enjoyable experience with tasty drinks and a vibrant setting.

Head back to your accommodation in Siena and get some rest in preparation for another magical day of your road trip in Italy!

Experience an unparalleled adventure on day 8 of your road trip in Italy. This exciting part of your journey invites you to discover the renowned landmarks in 1 vibrant destinations - Rome. After a day filled with exploration and new experiences, you will retreat to the hotel of your choice in Rome. You will spend 2 nights here for some well-deserved relaxation.

Enjoy the perfect balance of relaxation and exploration in Siena today. One of the most wondrous attractions included on the itinerary is Colosseum. This culturally significant archeological site will help you start your sightseeing on top. Then, take a leisurely stroll to Roman Forum and learn what makes this culturally significant archeological site unique.

Throughout the day, make sure to take breaks to appreciate the surroundings. Next up, visit the world-famous Trevi Fountain. After exploring the monument, head to Pantheon. This globally renowned monument is a highlight in Siena. As your day continues, stop by Piazza Navona, known for its romantic features.

After soaking up all the sights of today's itinerary, you'll be ready to head in the direction of your accommodation in Rome. Rome offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Rome. Enjoy a relaxing evening as you savor delicious local cuisine and reflect on the day's adventures.

Make sure to reserve a table at La Bottega Roma, an iconic dining spot in Rome. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Pasta In Corso, a popular restaurant in Rome. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of Trattoria Vecchia Roma, a hidden gem nestled in Rome. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

Explore the vibrant nightlife at La Botticella Of Poggi Giovanni after your meal, a hub for lively evenings and memorable moments. Or, head to Almalu Trastevere for a great selection of flavorful drinks and a charming setting. Furthermore, Bar Viminale Di Pepi Maurilio is perfect for those looking to extend their night with a touch of local flavor.

Head back to your accommodation in Rome and get some rest in preparation for another magical day of your road trip in Italy!

On day 9 of your road trip in Italy, you’ll start and end your day in Rome, but spend the day exploring what’s beyond the city. Since you will return to Rome for 1 night more, there’s no need to rush. Experience Vatican City to the fullest today with this curated day itinerary!

At the top of the list of things to do today is to explore Trastevere, a neighborhood that captures the true essence of Vatican City. Take your time to uncover its best sides and enjoy its proximity to many of the area’s best attractions. Another must-visit is Monti, a neighborhood offering a different perspective on Vatican City.

Sistine Chapel is your next stop. This astonishing chapel is one of the best-rated sights in Rome.

Consider grabbing some lunch or a light snack to keep your energy going. Beyond the above-mentioned attractions, today is also the perfect time to visit St. Peter's Basilica.

When you’re done exploring for the day, you’ll return to Rome and your accommodation.

Indulge in a memorable dining experience at one of Rome's most popular restaurants, and connect with friendly locals for an authentic adventure.

Dine in style at RomAntica, a top recommendation for dinner tonight. Or, for a change of pace, Coso Ristorante boasts a menu that's sure to impress. Also, be sure to check out DEROMA - Farine Romane. Known as a local hotspot, it’s a great choice for tonight in Rome.

If you’re not ready to end the night just yet, Sant' Eustachio Caffè offers a perfect venue to relax and savor a drink. Similarly, Yellowsquare Rome is well-suited for those looking to unwind in a social setting. Caffè Portofino is another excellent spot to enjoy a nightcap after a delightful meal.

Relax and reminisce about your day in Italy and look forward to more memorable moments to come!

Dive into day 10 of your remarkable road trip in Italy. Today you will explore Santa Maria degli Angeli, where you will have the opportunity to experience all the top things to see and do. At the end of the day, you’ll unwind at one of the finest accommodations in Santa Maria degli Angeli. You’ll stay here for 1 night.

A blend of family-friendly attractions, scenic views, and photo-friendly spots await you in Rome on today’s itinerary. First up is the interesting church, Basilica Of San Francesco D'assisi. Afterward, continue to Rocca Maggiore, a castle every traveler should visit.

As you explore Rome’s charming streets, take in the lively atmosphere and get to know the character of the town. Next, make your way to Piazza Del Comune. This beloved public square is an essential stop. Following that, head to Church Of Santa Maria Sopra Minerva In Assisi, another must-visit site that will enhance your experience.

At the end of the day, you will drive to Santa Maria degli Angeli, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

After a day of adventure, treat yourself to an exquisite dinner at one of Santa Maria degli Angeli's best restaurants.

Continue your lively evening at Bibenda Assisi Wine Tasting & Gourmet Food, Olive Oil And Chocolate Tastings, a perfect place for winding down or revving up the night, depending on which mood you’re in.

Relax and recharge in preparation for another adventurous day in Italy!