12-Day Italy Self-Drive Road Trip With Itinerary from Brindisi to Lecce, Naples, and Rome

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Ostuni white town skyline at sunset, Brindisi, Apulia southern Italy. Europe.
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Experience the freedom of the open road in Italy as you embark on an unforgettable 12-day road trip! This experience caters to every traveler, featuring destinations like Brindisi, Lecce, Alberobello, Matera, Naples, Alberi, Positano, Furore, Amalfi, Ravello, and Rome.

This perfectly planned road trip itinerary in Italy takes you through some of the best places to see in the country. You will spend 2 nights in Brindisi, 4 nights in Lecce, 4 nights in Naples, and 1 night in Rome. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Italy. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have got you covered.

Upon arriving in Brindisi, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Italy on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Italy. Trevi Fountain and Colosseum are just a couple of the bucket-list attractions that await your discovery. Marvel at the remarkable Pantheon, learn more about the unique Piazza Navona, and immerse yourself in the vibrant atmosphere of St. Peter's Basilica.

As you hit the open road and drive through Brindisi, Lecce, Alberobello, Matera, Naples, Alberi, Positano, Furore, Amalfi, Ravello, and Rome, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Italy. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Italy.

Throughout your road trip in Italy, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Italy.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodation, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in Italy fill up quickly, so book your spot early. Select a date and start planning your road trip in Italy today!

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Day 1

Day 1

  • Brindisi - Arrival day
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  • Colonne Romane
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Your road trip adventure in Italy begins as soon as you reach Brindisi and pick up your car. You’ll stay in Brindisi for 1 night and explore the best things to see and do, sample the local cuisine, and choose from a curated selection of the best hotels and places to stay in the city.

Brindisi is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out End Of The Via Appia Antica, or just taking a stroll in the city center. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

Find your way to your hotel in Brindisi. We recommend choosing a hotel in a central location for easy exploring. Check-in typically starts between 2 and 4 PM at hotels in Italy. Settle in and make plans for the evening.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Brindisi, it's often a good idea to reserve a table in advance.

Enjoy a lovely dining experience at Bracerie Escosazio, a popular restaurant in Brindisi. This acclaimed establishment has earned the admiration of countless food lovers in the city. Alternatively, experience a taste of Brindisi at Penny, another great place to eat. With a menu designed to impress, it promises a journey of flavors that will leave you captivated. A third option to check out is the top-rated Piadineria. It’s yet another ideal choice to enhance your time in Brindisi tonight.

Round off your dining experience by visiting Peddy Bar. Pasticceria. Gelateria. Happyhour. Prodotti Celiaci. Slot Machines. Scommesse, a prime location for a drink. Alternatively, explore the distinctive characteristics of Eden Cafè, a bar catering to every mood and preference. Altair Cafè likewise offers a unique atmosphere, perfect for a memorable night out.

Raise a toast to the start of your 12-day road trip in Italy!

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Day 2

Day 2

  • Brindisi
  • Lecce
  • More

Drive 39 km, 53 min

  • Chiesa Rettoria del Santissimo Crocifisso
  • Castello Carlo V
  • Benedictine Monastery
  • More

Dive into day 2 of your remarkable road trip in Italy. Today you will explore Brindisi and Lecce, where you will have the opportunity to experience all the top things to see and do. At the end of the day, you’ll unwind at one of the finest accommodations in Lecce. You’ll stay here for 4 nights.

A blend of family-friendly attractions, photo-friendly spots, and historic treasures await you in Brindisi on today’s itinerary. First up is the underrated church, Chiesa Rettoria Del Santissimo Crocifisso. Afterward, continue to Castle Of Charles V, a castle every traveler should visit.

As you explore Brindisi’s charming streets, take in the lively atmosphere and get to know the character of the city. Next, make your way to Benedictine Monastery. This locally appreciated monastery is an essential stop.

At the end of the day, you will drive to Lecce, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

Indulge in a memorable dining experience at one of Lecce's most popular restaurants, and connect with friendly locals for an authentic adventure.

Treat yourself to a wonderful meal at Alle due Corti, a top-rated dining spot in Lecce. If you're in the mood for something new, try Il Ristoro dei Templari Trattoria Pizzeria Braceria, another premier location with a delectable menu. You might also want to book a table at La Cucina di Mamma Elvira. Known for its consistently satisfied patrons, it’s a perfect choice to elevate your evening in Lecce.

Extend your evening after a delightful meal by visiting Sensi, which offers the perfect atmosphere for a night out. Moreover, Caffè Alvino is another popular option for a drink or two. Likewise, Jolly Roger also provides a great ambiance for reminiscing about the day and raising a toast to your vacation.

Raise your glass and celebrate another amazing day of your road trip in Italy!

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Day 3

Day 3

  • Lecce
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Drive 0.7 km, 9 min

  • Jewish Museum Lecce
  • Basilica di Santa Croce
  • Palazzo dei Celestini (Provincia di Lecce)
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On day 3 of your road trip, you will have an entire day to explore Lecce. You’ll stay in Lecce for 3 nights and discover all the best things to see and do in the area.

Enjoy the perfect balance of relaxation and exploration in Lecce today. One of the most curiosity-inducing attractions included on the itinerary is Jewish Museum Lecce. This heritage-rich museum will help you start your sightseeing on top. Then, take a leisurely stroll to Basilica Di Santa Croce and learn what makes this culturally significant church unique.

Throughout the day, make sure to take breaks to appreciate the surroundings. Next up, visit the worthwhile Palazzo Dei Celestini (provincia Di Lecce).

Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.

After a day of adventure, treat yourself to an exquisite dinner at one of Lecce's best restaurants.

Make sure to reserve a table at Miro Coffee Bistrot & Lounge Bar, an iconic dining spot in Lecce. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Oscar Cafè, a popular restaurant in Lecce. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of La Vecchia Osteria da Totu, a hidden gem nestled in Lecce. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

Cap off your dinner by heading to Bar Il Palio, ideal for a leisurely evening with a drink in hand. Al Ventuno is another bar that offers an enjoyable setting. Similarly, Avio is also a popular place to go on a night out, perfect for relaxing and socializing.

Celebrate another amazing day of your road trip adventure in Italy!

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Day 4

Day 4

  • Lecce
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Drive 229 km, 2 hours 55 min

  • Trullo Siamese monumento negozio souvenir
  • Trulli di Alberobello Puglia
  • Casa D'Amore
  • More

On day 4 of your road trip, you’ll start and end your day in Lecce, but spend part of the day exploring places of interest outside the immediate city. On today's itinerary, you'll find attractions in Alberobello. You still have 2 nights left in Lecce.

Discover a day packed with fun adventures, picturesque spots, and history-rich sites in Lecce. Begin your sightseeing with Trullo Siamese - Negozio Souvenirs. This intriguing gift shop is one of the top attractions in the town. Proceed to Trulli Di Alberobello Puglia, another must-visit attraction.

As you wander through the inviting streets of Lecce, soak in the lively ambiance and take the opportunity to snap some photos. Next, head to Casa D'amore. This frequently visited historical landmark is a traveler-favorite.

When you’re done exploring the area’s best attractions, you’ll drive back to your accommodation in Lecce.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Lecce. Enjoy a relaxing evening as you savor delicious local cuisine and reflect on the day's adventures.

Enjoy a lovely dining experience at L'OSTRICA UBRIACA di viale della Libertà, a popular restaurant in Lecce. This acclaimed establishment has earned the admiration of countless food lovers in the city. Alternatively, experience a taste of Lecce at L'angolino di Via Matteotti, another great place to eat. With a menu designed to impress, it promises a journey of flavors that will leave you captivated. A third option to check out is the top-rated Bar L'Incontro | Caffetteria, Pasticceria, Rosticceria. It’s yet another ideal choice to enhance your time in Lecce tonight.

Continue your evening by exploring the vibrant nightlife scene at Quanto Basta, a prime destination for a thrilling night out.

Relax and recharge in preparation for another adventurous day in Italy!

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Day 5

Day 5

  • Lecce
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Drive 381 km, 4 hours 31 min

  • Sassi di Matera
  • Sasso Caveoso
  • Casa Grotta del Casalnuovo
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Greet day 5 of your road trip in Italy with a smile and start your day with a hearty breakfast. You will return to Lecce for your remaining 1 night in the city later today, but first, it’s time for some exploring! On the agenda for this day, you’ll find only the best things to see and do in Matera.

Today, you'll explore some of the most beautiful places in Lecce, including an archeological site, a cave system, and a cave. Start your day with a visit to Sassi Di Matera. This notable archeological site is a must-visit in the city. When you’re ready for your next discovery, continue to Sasso Caveoso, which may be one of the most romantic places you will experience today.

One of the best things about exploring Lecce on a self-guided tour is that you set the pace. There’s plenty of time for detours and discovering hidden gems. When you’re ready for your next stop, make your way to Casa Grotta Del Casalnuovo, an up-and-coming cave in the city.

When you’re done exploring for the day, you’ll return to Lecce and your accommodation.

Indulge in a memorable dining experience at one of Lecce's most popular restaurants, and connect with friendly locals for an authentic adventure.

Enjoy a delicious meal at Opera Lounge - Lecce, a highly-rated dining destination in Lecce. If you're eager to try something different, consider A'Roma l'Osteria, another top spot with a tantalizing menu. You might also want to secure a reservation at Bar Meeting Di Mattia De Vincenza. With a reputation for consistently satisfying customers, it’s an excellent choice to enhance your stay in Lecce this evening.

Relax and reminisce about your day in Italy and look forward to more memorable moments to come!

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Day 6

Day 6

  • Lecce
  • Naples
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Drive 414 km, 4 hours 28 min

  • Castel Nuovo
  • piazza del Plebiscito
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On day 6 of your exciting self-drive vacation in Italy, you’ll soak in the magnificence of 1 destination, Naples. When you’re not sightseeing, take time to relax at your selected hotel in Naples, where you’ll be staying for 4 nights.

Lecce is home to plenty of attractions that offer fun adventures, breathtaking views, and photo-friendly spots! Start at Castel Nuovo, an interesting castle that is worthwhile a visit in the city. Nearby, you’ll find Piazza Del Plebiscito, enchanting visitors with its enchanting appeal.

After soaking up all the sights of today's itinerary, you'll be ready to head in the direction of your accommodation in Naples. Naples offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Naples. Enjoy a relaxing evening as you savor delicious local cuisine and reflect on the day's adventures.

Dine in style at L'Oca Nera Irish Pub, a top recommendation for dinner tonight. Or, for a change of pace, Mimì alla Ferrovia boasts a menu that's sure to impress. Also, be sure to check out Spuzzulè Winebar. Known as a local hotspot, it’s a great choice for tonight in Naples.

After enjoying a fulfilling meal, continue your evening at Happening Cocktail Bar, ideal for those looking to unwind with a drink in a comfortable setting. Alternatively, Shanti Art Musik Bar offers a welcoming atmosphere for easing into the nightlife. Similarly, Gran Caffè Gambrinus provides an excellent environment for a relaxed and enjoyable evening.

Head back to your accommodation in Naples and get some rest in preparation for another magical day of your road trip in Italy!

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Day 7

Day 7

  • Naples
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Drive 11 km, 1 hour 22 min

  • Castel Sant'Elmo
  • Naples National Archaeological Museum
  • Cappella Sansevero
  • Napoli Sotterranea Percorso Ufficiale
  • Cattedrale di Santa Maria Assunta
  • More

Day 7 of your road trip across Italy promises a magnificent time exploring Naples. You have 3 nights left in Naples. Take the opportunity to experience more of the best attractions and activities in the city.

Bring your curiosity for today’s adventure around Naples. Some of the city’s most loved attractions await! Castel Sant'elmo is the perfect place to start. This castle is one of the most well-known places to visit in Naples. Next, head to Naples National Archaeological Museum, a well-known museum, known for its photogenic features.

In between the sights, don’t hesitate to take small detours to explore local stores and eateries. When you’re ready to continue your adventure, head to Cappella Sansevero. This photogenic museum is a highly recommended experience. Nearby, you'll also find Napoli Sotterranea Percorso Ufficiale and Cattedrale Di Santa Maria Assunta. Visit these for an interesting touch to your journey.

Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Naples. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Treat yourself to a delicious dinner at Antica Pizzeria Di Matteo, an excellent option for tonight's dining. Looking for something different? Mercure Napoli Centro Angioino offers a tantalizing alternative with its diverse menu. And don’t miss La Lazzara Trattoria e Pizzeria. With its reputation for pleasing customers, it’s a fantastic choice for tonight in Naples.

Explore the vibrant nightlife at Archivio Storico - Cocktail Bar & Wonderfood after your meal, a hub for lively evenings and memorable moments. Or, head to Archeobar for a great selection of flavorful drinks and a charming setting. Furthermore, Babette Pub is perfect for those looking to extend their night with a touch of local flavor.

As the sun sets on another day of adventure, rest up and recharge for the next leg of your road trip in Italy.

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Day 8

Day 8

  • Naples
  • More

Drive 135 km, 3 hours 35 min

  • Belvedere Sorrento
  • Costiera Amalfitana Positano
  • Fiordo di Furore
  • More

At the end of the day, you'll drive back to Naples, where you'll stay for 2 nights more.

Whether you prefer a leisurely exploration or a more fast-paced adventure, this itinerary in Naples allows for both. Start by heading to Belvedere Sorrento. This beloved observation deck provides an insightful glimpse into the village's identity. Next, discover Costiera Amalfitana Positano, an eye-catching beach, promising a delightful encounter.

Continue your sightseeing with a visit to Fiordo Di Furore, an often recommended fjord.

When you’re done exploring the area’s best attractions, you’ll drive back to your accommodation in Naples.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Naples. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Savor the flavors at Opera Restaurant, a top pick for dinner tonight. Alternatively, Trattoria San Ferdinando beckons with its unique menu offerings. Also, consider Anonymous Trattoria Gourmet. With its consistent customer satisfaction, it’s an excellent option for dining in Naples tonight.

Following your dinner, dive into the local bar culture at Gran Caffè Cimmino. Enjoy this evening's relaxed ambiance with delightful drinks. Alternatively, go to Flanagan's Bar, the perfect place for those looking to experience the best of the nightlife. Similarly, Bar Napoli provides excellent drinks and a great atmosphere, ensuring a memorable night out.

As the sun sets on another day of adventure, rest up and recharge for the next leg of your road trip in Italy.

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Day 9

Day 9

  • Naples
  • More

Drive 123 km, 3 hours 11 min

  • Amalfi Coast
  • Villa Cimbrone Gardens
  • Villa Rufolo
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On day 9 of your road trip in Italy, you’ll start and end your day in Naples, but spend the day exploring what’s beyond the city. Since you will return to Naples for 1 night more, there’s no need to rush. Experience Amalfi, Castiglione, and Ravello to the fullest today with this curated day itinerary!

Brace yourself for today’s incredible lineup of attractions in Naples, featuring fun adventures, romantic experiences, and breathtaking views. Start at Amalfi Coast, a famous coast in the village. Then, head to Villa Cimbrone Gardens and soak in the ambiance of this enchanting botanical garden.

There are many interesting places to see in Naples, and when you are ready for more, go to Villa Rufolo. This is one of the village’s most popular enchanting spots of interest.

When you’re done exploring for the day, you’ll return to Naples and your accommodation.

As you explore more of Naples, you'll discover that its culinary landscape is as diverse as its attractions. Whether you're craving traditional dishes bursting with local flavors or innovative creations that push the boundaries of taste, you're sure to find a dining experience that satisfies your cravings.

Treat yourself to a wonderful meal at Piazza Sannazaro, a top-rated dining spot in Naples. If you're in the mood for something new, try Osteria Il Gobbetto, another premier location with a delectable menu. You might also want to book a table at Trattoria Castel Nuovo. Known for its consistently satisfied patrons, it’s a perfect choice to elevate your evening in Naples.

Keep the evening going at Parthenope Bar, a great choice for enjoying the after-dinner hours with a drink. You could also go to Gran Caffè Mexico, which offers a similarly pleasant setting and great drinks. Another option is Novecento Wine Bar, which provides an inviting environment for unwinding after a busy day out.

Raise your glass to another unforgettable day in Italy!

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Day 10

Day 10

  • Naples
  • Rome
  • More

Drive 232 km, 3 hours 26 min

  • Colosseum
  • Roman Forum
  • Trevi Fountain
  • Pantheon
  • Piazza Navona
  • More

Embark on another extraordinary experience on day 10 of your road trip in Italy. Today, you will make 1 stop and experience some of the highlights of Rome. At the end of the day, you will enjoy the comforts of a top-rated hotel in Rome, which will be your home away from home for 1 night.

Immerse yourself in Naples’s rich culture with today's sightseeing itinerary. Start your journey at Colosseum. This respected archeological site is sure to ignite your curiosity. Next, dive into the UNESCO world heritage-designated features of Roman Forum, a must-visit archeological site in the city.

In between sights, stop by local stores, picturesque photo spots, and small eateries. When you’re ready for your next attraction, proceed to Trevi Fountain, an iconic monument. For a change of scene, check out Pantheon, known for its heritage-rich features. We also recommend visiting Piazza Navona. This public square is a must for anyone looking to experience the city to the fullest.

When you’re done exploring for the day, you’ll drive to your hotel in Rome. Check in and spend some time relaxing before you head out to tour the city.

As you explore more of Rome, you'll discover that its culinary landscape is as diverse as its attractions. Whether you're craving traditional dishes bursting with local flavors or innovative creations that push the boundaries of taste, you're sure to find a dining experience that satisfies your cravings.

Savor the flavors at La Bottega Roma, a top pick for dinner tonight. Alternatively, Pasta In Corso beckons with its unique menu offerings. Also, consider Trattoria Vecchia Roma. With its consistent customer satisfaction, it’s an excellent option for dining in Rome tonight.

Let the evening flow smoothly from dinner to drinks at La Botticella Of Poggi Giovanni, a top-rated bar in the area. For other recommendations, Almalu Trastevere provides a perfect setting for rounding out your night with style and great drinks. Likewise, Bar Viminale Di Pepi Maurilio offers a memorable night with diverse drink options and excellent service.

Raise your glass to another unforgettable day in Italy!

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Day 11

Day 11

  • Rome
  • Brindisi
  • More

Drive 581 km, 6 hours 17 min

  • St Peter's Basilica
  • The Last Judgment
  • More

On day 11 of your road trip in Italy, you will get a true taste of the freedom a self-drive vacation in Europe entails. Today’s travel plans include stops at the most scenic, wondrous, and interesting places in Vatican City. In the evening, you’ll end up in Brindisi, where you will stay for 1 night.

Start your day with a visit to St. Peter's Basilica. This timeless major basilica is a must-visit in the city.

At the end of the day, you will drive to Brindisi, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

As dinnertime approaches, it's time to head out for a bite to eat in Brindisi. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.

Have a fantastic dining experience at Betty - Gelateria Cafe Ristorante Pizzeria a Brindisi, a highly recommended choice for tonight's dinner. If you're looking to mix things up, Bento offers an enticing alternative with its varied menu. Additionally, Cozza Nera is worth considering. Renowned for satisfying diners, it’s an ideal option for tonight in Brindisi.

Get a good night's sleep and look forward to another great day on the road in Italy!

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Day 12

Day 12

  • Brindisi - Departure day
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  • Saint Pietro of Schiavoni Archeologica Area
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Day 12 of your road trip in Italy is your departure day. This is your chance to catch a last glimpse of Brindisi before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

If you're up for some more sightseeing, begin at Saint Pietro Of Schiavoni Archeologica Area. This locally appreciated archeological site is a popular place to see in the city.

On your last day in Italy, take time to indulge in shopping at Brindisi’s popular marketplace. Look for keepsakes or souvenirs to remind you of your trip.

Before you conclude your road trip in Italy, drop by another restaurant for a last chance at a memorable dining experience in Brindisi.

If you're in the mood for something new, try Pizzeria La Nassa, another premier location with a delectable menu.

You’ll then say farewell to Brindisi. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Italy!

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Enjoy seamless planning
With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.
Explore with confidence
From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.
Secure your spot
Confirm your package instantly and lock in the best rate with secure payment and guaranteed availability.
Get instant confirmation
Shortly after booking, you’ll receive your full itinerary, including schedules, locations, and everything you need for a stress-free trip.
Personalize your itinerary
Each package includes a professionally crafted itinerary you can tailor to your travel style. A dedicated travel expert will make sure every detail fits your needs perfectly.
Easily make changes
Need to update plans? No problem. Whether before your trip or mid-journey, we’re just seconds away to help with quick adjustments.
Enjoy seamless planning
With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.
Explore with confidence
From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.

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