12-Day Italy Self-Drive Road Trip With Itinerary from Brindisi to Lecce, Naples, and Rome
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Escape the ordinary with this exciting 12-day road trip through Italy. Explore the diverse landscapes, lively cities, and beyond. Pack your bags, hit the road, and prepare for an unforgettable journey!
This perfectly planned road trip itinerary in Italy takes you through some of the best places to see in the country. You will spend 2 nights in Brindisi, 4 nights in Lecce, 4 nights in Naples, and 1 night in Rome. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!
With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Italy. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have got you covered.
Upon arriving in Brindisi, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Italy on your own terms.
An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Italy. Trevi Fountain and Colosseum are just a couple of the bucket-list attractions that await your discovery. Marvel at the remarkable Pantheon, learn more about the unique Piazza Navona, and immerse yourself in the vibrant atmosphere of St. Peter's Basilica.
As you hit the open road and drive through Brindisi, Lecce, Alberobello, Matera, Naples, Alberi, Positano, Furore, Amalfi, Ravello, and Rome, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Italy. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Italy.
Throughout your road trip in Italy, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Italy.
This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodation, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.
The best services in Italy fill up quickly, so book your spot early. Select a date and start planning your road trip in Italy today!
Itinerary summary
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Day 1
- Brindisi - Arrival day
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- Colonne Romane
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Your road trip adventure in Italy begins as soon as you reach Brindisi and pick up your car. You’ll stay in Brindisi for 1 night and explore the best things to see and do, sample the local cuisine, and choose from a curated selection of the best hotels and places to stay in the city.
Brindisi is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out End Of The Via Appia Antica, or just taking a stroll in the city center. Soak in the lovely atmosphere and sit down for a bit to eat or drink.
Find your way to your hotel in Brindisi. We recommend choosing a hotel in a central location for easy exploring. Check-in typically starts between 2 and 4 PM at hotels in Italy. Settle in and make plans for the evening.
As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Brindisi, it's often a good idea to reserve a table in advance.
Enjoy a lovely meal at Bracerie Escosazio, a top-rated place to have dinner tonight. Alternatively, if your taste buds call for something different, Penny is another top choice with a popular menu. You could also check for a table at Piadineria. As an establishment that gains consistently high praises from customers, it’s an ideal choice in Brindisi tonight.
Let the evening flow smoothly from dinner to drinks at Peddy Bar. Pasticceria. Gelateria. Happyhour. Prodotti Celiaci. Slot Machines. Scommesse, a top-rated bar in the area. For other recommendations, Eden Cafè provides a perfect setting for rounding out your night with style and great drinks. Likewise, Altair Cafè offers a memorable night with diverse drink options and excellent service.
Raise a toast to the start of your 12-day road trip in Italy!
Day 2
- Brindisi
- Lecce
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Drive 39 km, 53 min
- Chiesa Rettoria del Santissimo Crocifisso
- Castello Carlo V
- Benedictine Monastery
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On day 2 of your road trip in Italy, you will get a true taste of the freedom a self-drive vacation in Europe entails. Today’s travel plans include stops at the most scenic, wondrous, and interesting places in Brindisi and Lecce. In the evening, you’ll end up in Lecce, where you will stay for 4 nights.
Today’s agenda in Brindisi includes a church, a castle, and a monastery. Chiesa Rettoria Del Santissimo Crocifisso is must-visit church and a great starting point for the day. Next, continue your journey to Castle Of Charles V, an increasingly popular castle, located just a leisurely stroll away. Next, head to Benedictine Monastery, a culturally significant monastery, also available for your discovery today.
At the end of the day, you will drive to Lecce, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.
As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Lecce. Enjoy a relaxing evening as you savor delicious local cuisine and reflect on the day's adventures.
Treat yourself to a delightful dinner at Alle due Corti, highly recommended for tonight's dining. Or, if you're feeling adventurous, why not try Il Ristoro dei Templari Trattoria Pizzeria Braceria? It's another excellent option with a diverse menu. Consider reserving a table at La Cucina di Mamma Elvira as well. Known for its consistent customer satisfaction, it’s an ideal pick for tonight in Lecce.
Let the evening flow smoothly from dinner to drinks at Sensi, a top-rated bar in the area. For other recommendations, Caffè Alvino provides a perfect setting for rounding out your night with style and great drinks. Likewise, Jolly Roger offers a memorable night with diverse drink options and excellent service.
As the sun sets on another day of adventure, rest up and recharge for the next leg of your road trip in Italy.
Day 3
- Lecce
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Drive 0.7 km, 9 min
- Jewish Museum Lecce
- Basilica di Santa Croce
- Palazzo dei Celestini (Provincia di Lecce)
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Day 3 of your road trip will take you to the best attractions Lecce has to offer. Cherish the 3 nights you have left in Lecce by discovering the best things there are to see and do in the city.
Discover a day packed with fun adventures, photo-friendly spots, and history-rich sites in Lecce. Begin your sightseeing with Jewish Museum Lecce. This often recommended museum is one of the top attractions in the city. Proceed to Basilica Di Santa Croce, another must-visit attraction.
As you wander through the inviting streets of Lecce, soak in the lively ambiance and take the opportunity to snap some photos. Next, head to Palazzo Dei Celestini (provincia Di Lecce). This often recommended palace is a traveler-favorite.
Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.
Indulge in a memorable dining experience at one of Lecce's most popular restaurants, and connect with friendly locals for an authentic adventure.
Enjoy a delicious meal at Miro Coffee Bistrot & Lounge Bar, a highly-rated dining destination in Lecce. If you're eager to try something different, consider Oscar Cafè, another top spot with a tantalizing menu. You might also want to secure a reservation at La Vecchia Osteria da Totu. With a reputation for consistently satisfying customers, it’s an excellent choice to enhance your stay in Lecce this evening.
To truly maximize your evening out, consider visiting Bar Il Palio after dinner. This bar is known for offering some of the best drinks and vibes in the city. Alternatively, head to Al Ventuno, another bar with an inviting ambiance. Similarly, Avio also offers a great atmosphere, ensuring a night filled with enjoyment and relaxation.
As the sun sets on another day of adventure, rest up and recharge for the next leg of your road trip in Italy.
Day 4
- Lecce
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Drive 229 km, 2 hours 55 min
- Trullo Siamese monumento negozio souvenir
- Trulli di Alberobello Puglia
- Casa D'Amore
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At the end of the day, you'll drive back to Lecce, where you'll stay for 2 nights more.
Bring your curiosity for today’s adventure around Lecce. Some of the town’s most loved attractions await! Trullo Siamese - Negozio Souvenirs is the perfect place to start. This gift shop is one of the most up-and-coming places to visit in Lecce. Next, head to Trulli Di Alberobello Puglia, a locally renowned historical landmark, known for its visually striking features.
In between the sights, don’t hesitate to take small detours to explore local stores and eateries. When you’re ready to continue your adventure, head to Casa D'amore. This UNESCO world heritage-listed historical landmark is a highly recommended experience. Visit these for an interesting touch to your journey.
When you’re done exploring for the day, you’ll return to Lecce and your accommodation.
As you explore more of Lecce, you'll discover that its culinary landscape is as diverse as its attractions. Whether you're craving traditional dishes bursting with local flavors or innovative creations that push the boundaries of taste, you're sure to find a dining experience that satisfies your cravings.
Treat yourself to a wonderful meal at L'OSTRICA UBRIACA di viale della Libertà, a top-rated dining spot in Lecce. If you're in the mood for something new, try L'angolino di Via Matteotti, another premier location with a delectable menu. You might also want to book a table at Bar L'Incontro | Caffetteria, Pasticceria, Rosticceria. Known for its consistently satisfied patrons, it’s a perfect choice to elevate your evening in Lecce.
Let the evening flow smoothly from dinner to drinks at Quanto Basta, a top-rated bar in the area.
Head back to your accommodation in Lecce and get some rest in preparation for another magical day of your road trip in Italy!
Day 5
- Lecce
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Drive 381 km, 4 hours 31 min
- Sassi di Matera
- Sasso Caveoso
- Casa Grotta del Casalnuovo
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On day 5 of your road trip in Italy, you’ll start and end your day in Lecce, but spend the day exploring what’s beyond the city. Since you will return to Lecce for 1 night more, there’s no need to rush. Experience Matera to the fullest today with this curated day itinerary!
Get ready for an exciting day in Lecce. Today’s sightseeing agenda includes an archeological site, a cave system, and a cave. Begin your adventure at Sassi Di Matera. This is a popular archeological site you should not miss. Another must-see is Sasso Caveoso, an often recommended cave system in Lecce.
When you’re ready for the next sight, head to Casa Grotta Del Casalnuovo.
When you’re done exploring the area’s best attractions, you’ll drive back to your accommodation in Lecce.
As dinnertime approaches, it's time to head out for a bite to eat in Lecce. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.
Treat yourself to a delightful dinner at Opera Lounge - Lecce, highly recommended for tonight's dining. Or, if you're feeling adventurous, why not try A'Roma l'Osteria? It's another excellent option with a diverse menu. Consider reserving a table at Bar Meeting Di Mattia De Vincenza as well. Known for its consistent customer satisfaction, it’s an ideal pick for tonight in Lecce.
Raise your glass to another unforgettable day in Italy!
Day 6
- Lecce
- Naples
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Drive 414 km, 4 hours 28 min
- Castel Nuovo
- piazza del Plebiscito
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On day 6 of your exciting self-drive vacation in Italy, you’ll soak in the magnificence of 1 destination, Naples. When you’re not sightseeing, take time to relax at your selected hotel in Naples, where you’ll be staying for 4 nights.
Whether you prefer a leisurely exploration or a more fast-paced adventure, this itinerary in Lecce allows for both. Start by heading to Castel Nuovo. This popular castle provides an insightful glimpse into the city's identity. Next, discover Piazza Del Plebiscito, an enchanting public square, promising a delightful encounter.
When you’re done exploring for the day, you’ll drive to your hotel in Naples. Check in and spend some time relaxing before you head out to tour the city.
Indulge in a memorable dining experience at one of Naples's most popular restaurants, and connect with friendly locals for an authentic adventure.
Enjoy a delicious meal at L'Oca Nera Irish Pub, a highly-rated dining destination in Naples. If you're eager to try something different, consider Mimì alla Ferrovia, another top spot with a tantalizing menu. You might also want to secure a reservation at Spuzzulè Winebar. With a reputation for consistently satisfying customers, it’s an excellent choice to enhance your stay in Naples this evening.
After your meal, keep the night alive at a bar like Happening Cocktail Bar, known for its lively atmosphere. Shanti Art Musik Bar is another top recommendation that provides the perfect setting with well-crafted drinks and a welcoming ambiance. Similarly, Gran Caffè Gambrinus offers an excellent atmosphere for those looking to amp up the evening.
Savor another day of unforgettable experiences in Italy!
Day 7
- Naples
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Drive 11 km, 1 hour 22 min
- Castel Sant'Elmo
- Naples National Archaeological Museum
- Cappella Sansevero
- Napoli Sotterranea Percorso Ufficiale
- Cattedrale di Santa Maria Assunta
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Day 7 of your road trip across Italy promises a magnificent time exploring Naples. You have 3 nights left in Naples. Take the opportunity to experience more of the best attractions and activities in the city.
Get ready for an exciting day in Naples. Today’s sightseeing agenda includes a castle, a museum, a cave system, a church and much more! Begin your adventure at Castel Sant'elmo. This is a well-known castle you should not miss. Another must-see is Naples National Archaeological Museum, a captivating museum in Naples.
When you’re ready for the next sight, head to Cappella Sansevero. From there, take a leisurely stroll to Napoli Sotterranea Percorso Ufficiale, another of the city’s well-known attractions. We recommend continuing your self-guided tour at Cattedrale Di Santa Maria Assunta, a breathtaking place of interest in the city.
Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.
As you explore more of Naples, you'll discover that its culinary landscape is as diverse as its attractions. Whether you're craving traditional dishes bursting with local flavors or innovative creations that push the boundaries of taste, you're sure to find a dining experience that satisfies your cravings.
Treat yourself to a delicious dinner at Antica Pizzeria Di Matteo, an excellent option for tonight's dining. Looking for something different? Mercure Napoli Centro Angioino offers a tantalizing alternative with its diverse menu. And don’t miss La Lazzara Trattoria e Pizzeria. With its reputation for pleasing customers, it’s a fantastic choice for tonight in Naples.
After your meal, keep the night alive at a bar like Archivio Storico - Cocktail Bar & Wonderfood, known for its lively atmosphere. Archeobar is another top recommendation that provides the perfect setting with well-crafted drinks and a welcoming ambiance. Similarly, Babette Pub offers an excellent atmosphere for those looking to amp up the evening.
As the day draws to a close, take a moment to unwind and prepare for the next exciting chapter of your road trip in in Italy.
Day 8
- Naples
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Drive 135 km, 3 hours 35 min
- Belvedere Sorrento
- Costiera Amalfitana Positano
- Fiordo di Furore
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Greet day 8 of your road trip in Italy with a smile and start your day with a hearty breakfast. You will return to Naples for your remaining 2 nights in the city later today, but first, it’s time for some exploring! On the agenda for this day, you’ll find only the best things to see and do in Alberi, Positano, and Furore.
Savor the day by visiting some of the best places to see in Naples, including an observation deck, a beach, and a fjord. Start your adventure at Belvedere Sorrento. This worthwhile observation deck is a must-visit for travelers looking for a unique holiday experience. Make your way to Costiera Amalfitana Positano located in Naples for another exciting encounter.
Next, immerse yourself in the setting of Fiordo Di Furore. Its eye-catching features will captivate you.
When you’re done exploring for the day, you’ll return to Naples and your accommodation.
As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Naples. Enjoy a relaxing evening as you savor delicious local cuisine and reflect on the day's adventures.
Enjoy a delicious meal at Opera Restaurant, a top-rated dining destination in Naples. If you're in the mood to try something new, consider Trattoria San Ferdinando, another top spot with a mouthwatering menu. You might also want to secure a reservation at Anonymous Trattoria Gourmet. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Naples this evening.
Following your dinner, dive into the local bar culture at Gran Caffè Cimmino. Enjoy this evening's relaxed ambiance with delightful drinks. Alternatively, go to Flanagan's Bar, the perfect place for those looking to experience the best of the nightlife. Similarly, Bar Napoli provides excellent drinks and a great atmosphere, ensuring a memorable night out.
Relax and reminisce about your day in Italy and look forward to more memorable moments to come!
Day 9
- Naples
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Drive 123 km, 3 hours 11 min
- Amalfi Coast
- Villa Cimbrone Gardens
- Villa Rufolo
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Wake up to day 9 of your extraordinary road trip in Italy. With 1 night left in Naples, we encourage you to seize the day and discover the unexplored beauty of the city’s surroundings!
Immerse yourself in Naples’s rich culture with today's sightseeing itinerary. Start your journey at Amalfi Coast. Next, dive into the enchanting features of Villa Cimbrone Gardens, a must-visit botanical garden in the village.
In between sights, stop by local stores, picturesque photo spots, and small eateries. When you’re ready for your next attraction, proceed to Villa Rufolo, a notable historical landmark.
When you’re done exploring the area’s best attractions, you’ll drive back to your accommodation in Naples.
Indulge in a memorable dining experience at one of Naples's most popular restaurants, and connect with friendly locals for an authentic adventure.
Make sure to reserve a table at Piazza Sannazaro, an iconic dining spot in Naples. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Osteria Il Gobbetto, a popular restaurant in Naples. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of Trattoria Castel Nuovo, a hidden gem nestled in Naples. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.
Cap off your dinner by heading to Parthenope Bar, ideal for a leisurely evening with a drink in hand. Gran Caffè Mexico is another bar that offers an enjoyable setting. Similarly, Novecento Wine Bar is also a popular place to go on a night out, perfect for relaxing and socializing.
As the day draws to a close, take a moment to unwind and prepare for the next exciting chapter of your road trip in in Italy.
Day 10
- Naples
- Rome
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Drive 232 km, 3 hours 26 min
- Colosseum
- Roman Forum
- Trevi Fountain
- Pantheon
- Piazza Navona
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Embark on another extraordinary experience on day 10 of your road trip in Italy. Today, you will make 1 stop and experience some of the highlights of Rome. At the end of the day, you will enjoy the comforts of a top-rated hotel in Rome, which will be your home away from home for 1 night.
Set out on a day brimming with fun adventures, breathtaking views, and picturesque spots. Start at the globally renowned Colosseum, a picture-perfect archeological site in Naples. Next, go to Roman Forum.
After visiting Colosseum and Roman Forum, have a stroll along Naples's streets and take in the local charm. Continue your sightseeing by heading to Trevi Fountain. This masterful monument offers a unique experience. Pantheon is another noteworthy attraction worthwhile a visit. End your self-guided sightseeing tour on top with a visit to Piazza Navona, one of the most visually striking places to visit in Naples.
After soaking up all the sights of today's itinerary, you'll be ready to head in the direction of your accommodation in Rome. Rome offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.
As dinnertime approaches, it's time to head out for a bite to eat in Rome. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.
Treat yourself to a wonderful meal at La Bottega Roma, a top-rated dining spot in Rome. If you're in the mood for something new, try Pasta In Corso, another premier location with a delectable menu. You might also want to book a table at Trattoria Vecchia Roma. Known for its consistently satisfied patrons, it’s a perfect choice to elevate your evening in Rome.
Keep the excitement of the evening going by visiting a bar or two. La Botticella Of Poggi Giovanni is an excellent place to start. You could also check out Almalu Trastevere, offering a different kind of charm. A last recommendation for the day is Bar Viminale Di Pepi Maurilio. This bar promises an enjoyable experience with tasty drinks and a vibrant setting.
Relax and recharge in preparation for another adventurous day in Italy!
Day 11
- Rome
- Brindisi
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Drive 581 km, 6 hours 17 min
- St Peter's Basilica
- The Last Judgment
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Dive into day 11 of your remarkable road trip in Italy. Today you will explore Vatican City, where you will have the opportunity to experience all the top things to see and do. At the end of the day, you’ll unwind at one of the finest accommodations in Brindisi. You’ll stay here for 1 night.
The first attraction of today is St. Peter's Basilica.
Whether you decide to get entrance tickets for all attractions or you prefer admiring from a distance, amazing experiences await on this day in Rome.
At the end of the day, you will drive to Brindisi, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.
After a day of adventure, treat yourself to an exquisite dinner at one of Brindisi's best restaurants.
Savor the flavors at Betty - Gelateria Cafe Ristorante Pizzeria a Brindisi, a top pick for dinner tonight. Alternatively, Bento beckons with its unique menu offerings. Also, consider Cozza Nera. With its consistent customer satisfaction, it’s an excellent option for dining in Brindisi tonight.
Celebrate another amazing day of your road trip adventure in Italy!
Day 12
- Brindisi - Departure day
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- Saint Pietro of Schiavoni Archeologica Area
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Day 12 of your road trip in Italy is your departure day. This is your chance to catch a last glimpse of Brindisi before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.
If you're up for some more sightseeing, begin at Saint Pietro Of Schiavoni Archeologica Area. This underrated archeological site is a popular place to see in the city.
On your last day in Italy, take time to indulge in shopping at Brindisi’s popular marketplace. Look for keepsakes or souvenirs to remind you of your trip.
Before you conclude your road trip in Italy, drop by another restaurant for a last chance at a memorable dining experience in Brindisi.
Enjoy a lovely meal at Rendez-Vous Cafè Bistrot, a top-rated place to have dinner tonight. Alternatively, if your taste buds call for something different, Pizzeria La Nassa is another top choice with a popular menu.
You’ll then say farewell to Brindisi. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Italy!
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