12-Day Italy Self-Drive Road Trip With Itinerary from Brindisi to Lecce, Naples, and Rome

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Experience the freedom of the open road in Italy as you embark on an unforgettable 12-day road trip! This experience caters to every traveler, featuring destinations like Brindisi, Lecce, Alberobello, Matera, Naples, Alberi, Positano, Furore, Amalfi, Ravello, and Rome.

This perfectly planned road trip itinerary in Italy takes you through some of the best places to see in the country. You will spend 2 nights in Brindisi, 4 nights in Lecce, 4 nights in Naples, and 1 night in Rome. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Italy. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have got you covered.

Upon arriving in Brindisi, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Italy on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Italy. Trevi Fountain and Colosseum are just a couple of the bucket-list attractions that await your discovery. Marvel at the remarkable Pantheon, learn more about the unique Piazza Navona, and immerse yourself in the vibrant atmosphere of St. Peter's Basilica.

As you hit the open road and drive through Brindisi, Lecce, Alberobello, Matera, Naples, Alberi, Positano, Furore, Amalfi, Ravello, and Rome, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Italy. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Italy.

Throughout your road trip in Italy, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Italy.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodation, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in Italy fill up quickly, so book your spot early. Select a date and start planning your road trip in Italy today!

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Itinerary summary

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Days
Destination
Attractions
Overnight
Day
City & Overnight
Attractions
Colonne Romane
Chiesa Rettoria del Santissimo CrocifissoCastello Carlo VBenedictine Monastery
Jewish Museum LecceBasilica di Santa CrocePalazzo dei Celestini (Provincia di Lecce)
Trullo Siamese monumento negozio souvenirTrulli di Alberobello PugliaCasa D'Amore
Sassi di MateraSasso CaveosoCasa Grotta del Casalnuovo
Castel Nuovopiazza del Plebiscito

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Day 1

Day 1

  • Brindisi - Arrival day
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  • Colonne Romane
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Welcome to Brindisi, the perfect starting point for your road trip in Italy! Pick up your rental car and let the adventure begin. You will spend 1 night immersing yourself in Brindisi's charm before embarking on the next leg of your journey.

Brindisi is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out End Of The Via Appia Antica, or just taking a stroll in the city center. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

Find your way to your hotel in Brindisi. We recommend choosing a hotel in a central location for easy exploring. Check-in typically starts between 2 and 4 PM at hotels in Italy. Settle in and make plans for the evening.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Brindisi, it's often a good idea to reserve a table in advance.

Enjoy a delicious meal at Bracerie Escosazio, a top-rated dining destination in Brindisi. If you're in the mood to try something new, consider Penny, another top spot with a mouthwatering menu. You might also want to secure a reservation at Piadineria. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Brindisi this evening.

Explore the vibrant nightlife at Peddy Bar. Pasticceria. Gelateria. Happyhour. Prodotti Celiaci. Slot Machines. Scommesse after your meal, a hub for lively evenings and memorable moments. Or, head to Eden Cafè for a great selection of flavorful drinks and a charming setting. Furthermore, Altair Cafè is perfect for those looking to extend their night with a touch of local flavor.

Raise a toast to the start of your 12-day road trip in Italy!

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Day 2

Day 2

  • Brindisi
  • Lecce
  • More

Drive 39 km, 53 min

  • Chiesa Rettoria del Santissimo Crocifisso
  • Castello Carlo V
  • Benedictine Monastery
  • More

Experience an unparalleled adventure on day 2 of your road trip in Italy. This exciting part of your journey invites you to discover the renowned landmarks in 2 vibrant destinations - Brindisi and Lecce. After a day filled with exploration and new experiences, you will retreat to the hotel of your choice in Lecce. You will spend 4 nights here for some well-deserved relaxation.

Brindisi is home to plenty of attractions that offer fun adventures, photo-friendly spots, and historic treasures! Start at Chiesa Rettoria Del Santissimo Crocifisso, a worthwhile church that is worthwhile a visit in the city. Nearby, you’ll find Castle Of Charles V, enchanting visitors with its instagrammable appeal. Continue your exploration at Benedictine Monastery. This monastery is one of the city’s most locally appreciated spots.

At the end of the day, you will drive to Lecce, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Lecce. Enjoy a relaxing evening as you savor delicious local cuisine and reflect on the day's adventures.

Treat yourself to a delicious dinner at Alle due Corti, an excellent option for tonight's dining. Looking for something different? Il Ristoro dei Templari Trattoria Pizzeria Braceria offers a tantalizing alternative with its diverse menu. And don’t miss La Cucina di Mamma Elvira. With its reputation for pleasing customers, it’s a fantastic choice for tonight in Lecce.

Round off your dining experience by visiting Sensi, a prime location for a drink. Alternatively, explore the distinctive characteristics of Caffè Alvino, a bar catering to every mood and preference. Jolly Roger likewise offers a unique atmosphere, perfect for a memorable night out.

Celebrate another amazing day of your road trip adventure in Italy!

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Day 3

Day 3

  • Lecce
  • More

Drive 0.7 km, 9 min

  • Jewish Museum Lecce
  • Basilica di Santa Croce
  • Palazzo dei Celestini (Provincia di Lecce)
  • More

On day 3 of your road trip, you will have an entire day to explore Lecce. You’ll stay in Lecce for 3 nights and discover all the best things to see and do in the area.

Get ready for a day filled with family-friendly attractions, picturesque spots, and history-rich sites in the charming city of Lecce. Your adventure starts at Jewish Museum Lecce, a frequently visited local hot spot. Another notable attraction to explore is Basilica Di Santa Croce. This locally appreciated church is known for its heritage-rich appeal.

After soaking in the highlights of these sights, take some time to wander Lecce's streets and immerse yourself in the local atmosphere. When you're ready to continue your sightseeing adventure, head to Palazzo Dei Celestini (provincia Di Lecce). This culturally significant palace offers a fascinating experience that many visitors find memorable.

Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.

Indulge in a memorable dining experience at one of Lecce's most popular restaurants, and connect with friendly locals for an authentic adventure.

Have a fantastic dining experience at Miro Coffee Bistrot & Lounge Bar, a highly recommended choice for tonight's dinner. If you're looking to mix things up, Oscar Cafè offers an enticing alternative with its varied menu. Additionally, La Vecchia Osteria da Totu is worth considering. Renowned for satisfying diners, it’s an ideal option for tonight in Lecce.

Explore the vibrant nightlife at Bar Il Palio after your meal, a hub for lively evenings and memorable moments. Or, head to Al Ventuno for a great selection of flavorful drinks and a charming setting. Furthermore, Avio is perfect for those looking to extend their night with a touch of local flavor.

Say good night to Lecce and look forward to another great day of your road trip in Italy!

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Day 4

Day 4

  • Lecce
  • More

Drive 229 km, 2 hours 55 min

  • Trullo Siamese monumento negozio souvenir
  • Trulli di Alberobello Puglia
  • Casa D'Amore
  • More

Wake up to day 4 of your extraordinary road trip in Italy. With 2 nights left in Lecce, we encourage you to seize the day and discover the unexplored beauty of the city’s surroundings!

Brace yourself for today’s incredible lineup of attractions in Lecce, featuring fun adventures, picturesque spots, and history-rich sites. Start at Trullo Siamese - Negozio Souvenirs, a curiosity-inducing gift shop in the town. Then, head to Trulli Di Alberobello Puglia and soak in the ambiance of this history-steeped historical landmark.

There are many interesting places to see in Lecce and when you are ready for more, go to Casa D'amore. This is one of the town’s most often recommended spots.

When you’re done exploring the area’s best attractions, you’ll drive back to your accommodation in Lecce.

As dinnertime approaches, it's time to head out for a bite to eat in Lecce. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.

Savor the flavors at L'OSTRICA UBRIACA di viale della Libertà, a top pick for dinner tonight. Alternatively, L'angolino di Via Matteotti beckons with its unique menu offerings. Also, consider Bar L'Incontro | Caffetteria, Pasticceria, Rosticceria. With its consistent customer satisfaction, it’s an excellent option for dining in Lecce tonight.

Unwind after your meal by stepping into Quanto Basta. This venue is celebrated for its extensive drink selections and cozy vibes.

Celebrate another amazing day of your road trip adventure in Italy!

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Day 5

Day 5

  • Lecce
  • More

Drive 381 km, 4 hours 31 min

  • Sassi di Matera
  • Sasso Caveoso
  • Casa Grotta del Casalnuovo
  • More

Greet day 5 of your road trip in Italy with a smile and start your day with a hearty breakfast. You will return to Lecce for your remaining 1 night in the city later today, but first, it’s time for some exploring! On the agenda for this day, you’ll find only the best things to see and do in Matera.

Set out on a day brimming with fun adventures, romantic experiences, and breathtaking views. Start at the interesting Sassi Di Matera, an UNESCO world heritage-listed archeological site in Lecce. Next, go to Sasso Caveoso.

After visiting Sassi Di Matera and Sasso Caveoso, take time to explore Lecce's streets and absorb its charm. Continue your sightseeing by heading to Casa Grotta Del Casalnuovo. This instagrammable cave offers a unique experience.

When you’re done exploring for the day, you’ll return to Lecce and your accommodation.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Lecce. Enjoy a relaxing evening as you savor delicious local cuisine and reflect on the day's adventures.

Treat yourself to a delightful dinner at Opera Lounge - Lecce, highly recommended for tonight's dining. Or, if you're feeling adventurous, why not try A'Roma l'Osteria? It's another excellent option with a diverse menu. Consider reserving a table at Bar Meeting Di Mattia De Vincenza as well. Known for its consistent customer satisfaction, it’s an ideal pick for tonight in Lecce.

Head back to your accommodation in Lecce and get some rest in preparation for another magical day of your road trip in Italy!

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Day 6

Day 6

  • Lecce
  • Naples
  • More

Drive 414 km, 4 hours 28 min

  • Castel Nuovo
  • piazza del Plebiscito
  • More

Dive into day 6 of your remarkable road trip in Italy. Today you will explore Naples, where you will have the opportunity to experience all the top things to see and do. At the end of the day, you’ll unwind at one of the finest accommodations in Naples. You’ll stay here for 4 nights.

Today’s route brings family-friendly attractions, scenic views, and picturesque spots. The first attraction of today is Castel Nuovo. This captivating castle is a standout place to see in Lecce. Continue your discovery at Piazza Del Plebiscito, a grand public square with stories to tell.

Whether you decide to get entrance tickets for all attractions or you prefer admiring from a distance, amazing experiences await on this day in Lecce.

After soaking up all the sights of today's itinerary, you'll be ready to head in the direction of your accommodation in Naples. Naples offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Naples. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Enjoy a lovely dining experience at L'Oca Nera Irish Pub, a popular restaurant in Naples. This acclaimed establishment has earned the admiration of countless food lovers in the city. Alternatively, experience a taste of Naples at Mimì alla Ferrovia, another great place to eat. With a menu designed to impress, it promises a journey of flavors that will leave you captivated. A third option to check out is the top-rated Spuzzulè Winebar. It’s yet another ideal choice to enhance your time in Naples tonight.

To truly maximize your evening out, consider visiting Happening Cocktail Bar after dinner. This bar is known for offering some of the best drinks and vibes in the city. Alternatively, head to Shanti Art Musik Bar, another bar with an inviting ambiance. Similarly, Gran Caffè Gambrinus also offers a great atmosphere, ensuring a night filled with enjoyment and relaxation.

As the day draws to a close, take a moment to unwind and prepare for the next exciting chapter of your road trip in in Italy.

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Day 7

Day 7

  • Naples
  • More

Drive 11 km, 1 hour 22 min

  • Castel Sant'Elmo
  • Naples National Archaeological Museum
  • Cappella Sansevero
  • Napoli Sotterranea Percorso Ufficiale
  • Cattedrale di Santa Maria Assunta
  • More

Day 7 of your road trip will take you to the best attractions Naples has to offer. Cherish the 3 nights you have left in Naples by discovering the best things there are to see and do in the city.

Today’s agenda in Naples includes a castle, a museum, a cave system, a church and much more! Castel Sant'elmo is must-visit castle and a great starting point for the day. Next, continue your journey to Naples National Archaeological Museum, a popular museum, located just a leisurely stroll away. Next, head to Cappella Sansevero, a heritage-rich museum, also available for your discovery today.

Each stop on today’s itinerary promises to leave you with lasting memories and a deeper appreciation for Naples. If you’re looking for more, Napoli Sotterranea Percorso Ufficiale is also a notable attraction that is worthwhile a visit. Lastly, don’t miss Cattedrale Di Santa Maria Assunta, a locally renowned gem to see in the city.

Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.

As you explore more of Naples, you'll discover that its culinary landscape is as diverse as its attractions. Whether you're craving traditional dishes bursting with local flavors or innovative creations that push the boundaries of taste, you're sure to find a dining experience that satisfies your cravings.

Enjoy a delicious meal at Antica Pizzeria Di Matteo, a top-rated dining destination in Naples. If you're in the mood to try something new, consider Mercure Napoli Centro Angioino, another top spot with a mouthwatering menu. You might also want to secure a reservation at La Lazzara Trattoria e Pizzeria. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Naples this evening.

Keep the evening going at Archivio Storico - Cocktail Bar & Wonderfood, a great choice for enjoying the after-dinner hours with a drink. You could also go to Archeobar, which offers a similarly pleasant setting and great drinks. Another option is Babette Pub, which provides an inviting environment for unwinding after a busy day out.

As the day draws to a close, take a moment to unwind and prepare for the next exciting chapter of your road trip in in Italy.

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Day 8

Day 8

  • Naples
  • More

Drive 135 km, 3 hours 35 min

  • Belvedere Sorrento
  • Costiera Amalfitana Positano
  • Fiordo di Furore
  • More

On day 8 of your road trip in Italy, you’ll start and end your day in Naples, but spend the day exploring what’s beyond the city. Since you will return to Naples for 2 nights more, there’s no need to rush. Experience Alberi, Positano, and Furore to the fullest today with this curated day itinerary!

Discover a day packed with family-friendly attractions, romantic experiences, and breathtaking views in Naples. Begin your sightseeing with Belvedere Sorrento. This locally appreciated observation deck is one of the top attractions in the village. Proceed to Costiera Amalfitana Positano, another must-visit attraction that enhances the village’s allure.

As you wander through the inviting streets of Naples, soak in the lively ambiance and take the opportunity to snap some photos. Next, head to Fiordo Di Furore. This worthwhile fjord is a traveler-favorite.

When you’re done exploring the area’s best attractions, you’ll drive back to your accommodation in Naples.

As you explore more of Naples, you'll discover that its culinary landscape is as diverse as its attractions. Whether you're craving traditional dishes bursting with local flavors or innovative creations that push the boundaries of taste, you're sure to find a dining experience that satisfies your cravings.

Enjoy a lovely meal at Opera Restaurant, a top-rated place to have dinner tonight. Alternatively, if your taste buds call for something different, Trattoria San Ferdinando is another top choice with a popular menu. You could also check for a table at Anonymous Trattoria Gourmet. As an establishment that gains consistently high praises from customers, it’s an ideal choice in Naples tonight.

Round off your dining experience by visiting Gran Caffè Cimmino, a prime location for a drink. Alternatively, explore the distinctive characteristics of Flanagan's Bar, a bar catering to every mood and preference. Bar Napoli likewise offers a unique atmosphere, perfect for a memorable night out.

Raise your glass and celebrate another amazing day of your road trip in Italy!

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Day 9

Day 9

  • Naples
  • More

Drive 123 km, 3 hours 11 min

  • Amalfi Coast
  • Villa Cimbrone Gardens
  • Villa Rufolo
  • More

On day 9 of your road trip, you’ll start and end your day in Naples, but spend part of the day exploring places of interest outside the immediate city. On today's itinerary, you'll find attractions in Amalfi, Castiglione, and Ravello. You still have 1 night left in Naples.

Today’s route brings family-friendly attractions, romantic experiences, and scenic views. The first attraction of today is Amalfi Coast. Continue your discovery at Villa Cimbrone Gardens, a detailed botanical garden with stories to tell.

As you stroll around Naples, take in the distinct atmosphere and learn what makes this village so unique. Maximize your sightseeing with a visit to Villa Rufolo. This locally renowned historical landmark offers a visually striking encounter with Naples. Whether you decide to get entrance tickets for all attractions or you prefer admiring from a distance, amazing experiences await on this day in Naples.

When you’re done exploring for the day, you’ll return to Naples and your accommodation.

After a day of adventure, treat yourself to an exquisite dinner at one of Naples's best restaurants.

Dine in style at Piazza Sannazaro, a top recommendation for dinner tonight. Or, for a change of pace, Osteria Il Gobbetto boasts a menu that's sure to impress. Also, be sure to check out Trattoria Castel Nuovo. Known as a local hotspot, it’s a great choice for tonight in Naples.

After enjoying a delightful dinner, why not delve into the vibrant local bar scene? You might want to spend the evening at Parthenope Bar, a well-loved spot among locals and tourists. Or, head to Gran Caffè Mexico. This bar boasts a welcoming environment that is perfect for winding down. You could also continue your night at Novecento Wine Bar, another top-rated place in the area.

As the day draws to a close, take a moment to unwind and prepare for the next exciting chapter of your road trip in in Italy.

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Day 10

Day 10

  • Naples
  • Rome
  • More

Drive 232 km, 3 hours 26 min

  • Colosseum
  • Roman Forum
  • Trevi Fountain
  • Pantheon
  • Piazza Navona
  • More

On day 10 of your road trip in Italy, you will get a true taste of the freedom a self-drive vacation in Europe entails. Today’s travel plans include stops at the most scenic, wondrous, and interesting places in Rome. In the evening, you’ll end up in Rome, where you will stay for 1 night.

Savor the day by visiting some of the best places to see in Naples, including an archeological site, a monument, and a public square. Start your adventure at Colosseum. This timeless archeological site is a must-visit for travelers looking for a unique holiday experience. Make your way to Roman Forum located in Naples for an enchanting atmosphere.

Next, immerse yourself in the setting of Trevi Fountain. Its detailed features will captivate you. After the monument, continue your tour of the city with a visit to Pantheon. This monument has a heritage-rich appeal. For a change of pace, head to Piazza Navona. As one of the most wondrous attractions in Naples, this public square is an excellent place to end your self-guided tour.

When you’re done exploring for the day, you’ll drive to your hotel in Rome. Check in and spend some time relaxing before you head out to tour the city.

As dinnertime approaches, it's time to head out for a bite to eat in Rome. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.

Savor the flavors at La Bottega Roma, a top pick for dinner tonight. Alternatively, Pasta In Corso beckons with its unique menu offerings. Also, consider Trattoria Vecchia Roma. With its consistent customer satisfaction, it’s an excellent option for dining in Rome tonight.

Cap off your dinner by heading to La Botticella Of Poggi Giovanni, ideal for a leisurely evening with a drink in hand. Almalu Trastevere is another bar that offers an enjoyable setting. Similarly, Bar Viminale Di Pepi Maurilio is also a popular place to go on a night out, perfect for relaxing and socializing.

Head back to your accommodation in Rome and get some rest in preparation for another magical day of your road trip in Italy!

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Day 11

Day 11

  • Rome
  • Brindisi
  • More

Drive 581 km, 6 hours 17 min

  • St Peter's Basilica
  • The Last Judgment
  • More

On day 11 of your exciting self-drive vacation in Italy, you’ll soak in the magnificence of 1 destination, Vatican City. When you’re not sightseeing, take time to relax at your selected hotel in Brindisi, where you’ll be staying for 1 night.

When you’re ready, kick off your sightseeing adventure at St. Peter's Basilica. This wondrous major basilica is a must-visit for anyone seeking a unique vacation experience. Another sight you shouldn’t miss is The Last Judgment, one of the city’s best highlights.

At the end of the day, you will drive to Brindisi, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

As you explore more of Brindisi, you'll discover that its culinary landscape is as diverse as its attractions. Whether you're craving traditional dishes bursting with local flavors or innovative creations that push the boundaries of taste, you're sure to find a dining experience that satisfies your cravings.

Don’t miss out on dining at Betty - Gelateria Cafe Ristorante Pizzeria a Brindisi, a top-rated dining destination in Brindisi. If you're in the mood to try something new, consider Bento, another top spot with a mouthwatering menu. You might also want to secure a reservation at Cozza Nera. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Brindisi this evening.

Relax and reminisce about your day in Italy and look forward to more memorable moments to come!

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Day 12

Day 12

  • Brindisi - Departure day
  • More
  • Saint Pietro of Schiavoni Archeologica Area
  • More

Day 12 of your road trip in Italy is your departure day. This is your chance to catch a last glimpse of Brindisi before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

If you're up for some more sightseeing, begin at Saint Pietro Of Schiavoni Archeologica Area. This beloved archeological site is a popular place to see in the city.

Explore local shops for souvenirs to remember your trip or find unique gifts for loved ones.

Before you conclude your road trip in Italy, drop by another restaurant for a last chance at a memorable dining experience in Brindisi.

You’ll then say farewell to Brindisi. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Italy!

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