12-Day Italy Self-Drive Road Trip With Itinerary from Brindisi traveling west to Taranto, Salerno, Rome, Naples, and Bari

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Ostuni white town skyline at sunset, Brindisi, Apulia southern Italy. Europe.
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Explore the best of Italy on a remarkable 12-day road trip! Combine exploration with relaxation on a self-drive tour featuring Brindisi, Taranto, Matera, Salerno, Pompei, Caserta, Rome, Naples, Amalfi, Trani, and Bari.

This perfectly planned road trip itinerary takes you through some of the best places to see in Italy. You will spend 2 nights in Brindisi, 1 night in Taranto, 1 night in Salerno, 4 nights in Rome, 2 nights in Naples, and 1 night in Bari. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Italy. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have you covered.

Upon arriving in Brindisi, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Italy on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Italy. Trevi Fountain and Colosseum are just a couple of the bucket-list attractions that await your discovery. Marvel at the remarkable Pantheon, learn more about the unique Piazza Navona, and immerse yourself in the vibrant atmosphere of St. Peter's Basilica.

As you hit the open road and drive through Brindisi, Taranto, Matera, Salerno, Pompei, Caserta, Rome, Naples, Amalfi, Trani, and Bari, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Italy. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Italy.

Throughout your road trip in Italy, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Italy.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodations, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in Italy fill up quickly, so book your spot early. Select a date and start planning your road trip in Italy today!

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Day 1

Day 1

  • Brindisi - Arrival day
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  • Swabian Castle of Brindisi
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Your road trip adventure in Italy begins as soon as you reach Brindisi and pick up your car. You’ll stay here for 1 night and explore what to see in Brindisi, sample the local cuisine, and choose from a curated selection of the best hotels and places to stay in the city.

Brindisi is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out Swabian Castle Of Brindisi, or just taking a stroll in the city center. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

As afternoon approaches, head to your chosen hotel in Brindisi. Check-in typically starts around 2 to 4 PM at hotels in Italy. We recommend staying at a central location for easy access to key areas in the city.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Brindisi, it's often a good idea to reserve a table in advance.

Enjoy a lovely dining experience at Bracerie Escosazio, a popular restaurant in Brindisi. This acclaimed establishment has earned the admiration of countless food lovers in the city. Alternatively, experience a taste of Brindisi at Penny, another great place to eat. With a menu designed to impress, it promises a journey of flavors that will leave you captivated. A third option to check out is the top-rated Piadineria. It’s yet another ideal choice to enhance your time in Brindisi tonight.

Continue your evening by exploring the vibrant nightlife scene at Peddy Bar. Pasticceria. Gelateria. Happyhour. Prodotti Celiaci. Slot Machines. Scommesse, a prime destination for a thrilling night out. Also, don’t forget to check out Eden Cafè, a bar that offers unique local touches. Likewise, Altair Cafè provides an excellent alternative for a fun evening.

Raise a toast to the start of your 12-day road trip in Italy!

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Day 2

Day 2

  • Brindisi
  • Taranto
  • More

Drive 72 km, 1 hour 6 min

  • Plaza de la catedral
  • Portico dei Cavalieri Templari
  • Monumento alla Madonna Pellegrina
  • Basilica Cattedrale della Visitazione e San Giovanni Battista
  • Colonne Romane
  • More

On day 2 of your road trip in Italy, your travel plans include 1 stop at the most scenic, wondrous, and interesting places in the region. Brindisi are on today's agenda. In the evening, you’ll end up in Taranto, where you will stay for 1 night.

Make time for Plaza De La Catedral, an underrated public square that is worthwhile a visit in the city. Nearby, you’ll find Portico Dei Cavalieri Templari, enchanting visitors with its respected appeal. Continue your exploration at Monumento Alla Madonna Pellegrina. This monument is one of the city’s most often recommended spots.

Enjoy the freedom of exploring Brindisi at your own pace and find hidden gems along the way. If you want to see more picture-perfect spots, make sure to visit Cathedral Of The Visitation And Saint John Baptist. After exploring the church, head to the locally appreciated End Of The Via Appia Antica.

At the end of the day, you will drive to Taranto, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

After a day of adventure, treat yourself to an exquisite dinner at one of Taranto's best restaurants.

Don’t miss out on dining at Come Vuoi Pane & Condimenti, a top-rated dining destination in Taranto. If you're in the mood to try something new, consider Ricci - Pizzaioli dal 1963, another top spot with a mouthwatering menu. You might also want to secure a reservation at Ristorante La Pignata. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Taranto this evening.

After savoring a delicious meal, step into the vibrant nightlife at Bar Center, where the evening is just getting started. In the same way, Tabir offers a unique charm perfect for experiencing the local bar scene in Taranto. Old Fashion is another top-recommended bar that is sure to get you into the mood for some dancing and celebrating.

Raise your glass to another unforgettable day in Italy!

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Day 3

Day 3

  • Taranto
  • Salerno
  • More

Drive 267 km, 3 hours 45 min

  • Fontana
  • Ponte di Porta Napoli (Ponte di pietra)
  • Sassi di Matera
  • More

On day 3 of your exciting self-drive vacation in Italy, you’ll soak in the magnificence of 2 destinations, including Taranto and Matera. When you’re not sightseeing, take time to relax at your chosen hotel in Salerno, where you’ll be staying for 1 night.

No visit to Taranto is complete without Fontana. This often recommended monument is one of the top attractions in the city. Proceed to Ponte Di Porta Napoli (ponte Di Pietra), another must-visit attraction.

As you wander through the inviting streets of Taranto, soak in the lively ambiance and take the opportunity to snap some photos. Next, head to Sassi Di Matera. This well-known archeological site is a traveler-favorite.

When you’re done exploring for the day, you’ll drive to your hotel in Salerno. Check in and relax before you head out to tour the city.

Indulge in a memorable dining experience at one of Salerno's most popular restaurants, and connect with friendly locals for a true cultural experience.

Start your culinary exploration in Salerno by securing a reservation at Re Maurì. This renowned restaurant holds 1 Michelin star and offers an exceptional menu of creative cuisine. Immerse yourself in the culinary delights of L'Unico Drink & Food Salerno, a popular restaurant in Salerno. With a menu designed to delight, it ensures a dining experience that transcends the ordinary.

Following your dinner, dive into the local bar culture at Hilton Bar E Gastronomia. Enjoy this evening's relaxed ambiance with delightful drinks. Alternatively, go to The Black Monday Speakeasy Tbm, the perfect place for those looking to experience the best of the nightlife. Similarly, Dòmo I' Vinaino Wine Bar - Enogastronomia provides excellent drinks and a great atmosphere, ensuring a memorable night out.

As the day draws to a close, take a moment to unwind and prepare for the next exciting chapter of your road trip in Italy.

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Day 4

Day 4

  • Salerno
  • Rome
  • More

Drive 285 km, 4 hours 6 min

  • Archaeological Park of Pompeii
  • Amphitheatre of Pompeii
  • Palace of Caserta
  • Giardini Reali - Parco Reggia di Caserta
  • More

Dive into day 4 of your remarkable road trip in Italy. Today you'll explore 2 destinations, including Pompei and Caserta. At the end of the day, you’ll unwind at one of the finest accommodations in Rome, where you'll spend 4 nights.

One of the most well-known attractions included on the itinerary is Archaeological Park Of Pompeii. This breathtaking archeological site will help you start your sightseeing on top. Then, take a leisurely stroll to Amphitheatre Of Pompeii and learn what makes this UNESCO world heritage-listed archeological site unique.

Throughout the day, make sure to take breaks to appreciate the surroundings. Next up, visit the notable Palace Of Caserta. After exploring the palace, head to Giardini Reali - Parco Reggia Di Caserta. This notable park is a highlight in Salerno.

After soaking up all the sights on today's itinerary, you'll be ready to head to your accommodation in Rome. Rome offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Rome, it's often a good idea to reserve a table in advance.

Experience a taste of local culinary excellence while in Rome by securing a table at La Pergola. An esteemed 3-star Michelin restaurant, it features an exceptional mediterranean and contemporary menu. For an alternative taste experience, visit Il Pagliaccio, famous for its scrumptious creative and innovative dishes. This 2-star Michelin venue consistently impresses guests, making it a standout addition to your holiday plans. Looking for another choice? Discover Enoteca La Torre, a local favorite celebrated for its exquisite mediterranean and creative cuisine in Rome. Located in the heart of the city, this 2-star Michelin restaurant is an ideal pick for mediterranean and creative cuisine lovers seeking top-notch culinary experiences.

After your meal, keep the night alive at a bar like La Botticella Of Poggi Giovanni, known for its lively atmosphere. Almalu Trastevere is another top recommendation that provides the perfect setting with well-crafted drinks and a welcoming ambiance. Similarly, Bar Viminale Di Pepi Maurilio offers an excellent atmosphere for those looking to amp up the evening.

Savor another day of unforgettable experiences in Italy!

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Day 5

Day 5

  • Rome
  • More

Drive 8 km, 1 hour 2 min

  • Trevi Fountain
  • Piazza di Spagna
  • Spanish Steps
  • piazza del Popolo
  • Villa Borghese
  • More

Day 5 offers an itinerary packed with the best things to see in Rome. You’ll stay in Rome for 3 nights more, offering you enough time to explore at a relaxed pace.

Visiting Trevi Fountain is always a good idea. This iconic monument is a place that is appreciated by travelers and locals alike. Next, immerse yourself in the enchanting wonders of Piazza Di Spagna, a must-see public square in the city.

Consider stopping for a small bite to eat or a drink at a local eatery to keep your energy going. When you’re ready, continue your discovery with a visit to Spanish Steps. This astonishing public square offers an enriching experience. For a change of pace, head to Piazza Del Popolo, where you can take in symbolic features. Conclude your self-guided sightseeing tour with a visit to Villa Borghese. These sights offer a fulfilling end to a perfect day.

Don’t forget to check out all the popular tours and experiences you can add to your travel plans in Italy. You can explore and select activities under each day of your itinerary.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Rome. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Treat yourself to a wonderful meal at RomAntica, a top-rated dining spot in Rome. If you're in the mood for something new, try Coso Ristorante, another premier location with a delectable menu. You might also want to book a table at DEROMA - Farine Romane. Known for its consistently satisfied patrons, it’s a perfect choice to elevate your evening in Rome.

Let the evening flow smoothly from dinner to drinks at Sant' Eustachio Caffè, a top-rated bar in the area. For other recommendations, Yellowsquare Rome provides a perfect setting for rounding out your night with style and great drinks. Likewise, Caffè Portofino offers a memorable night with diverse drink options and excellent service.

Celebrate another amazing day of your road trip adventure in Italy!

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Day 6

Day 6

  • Rome
  • More

Drive 4 km, 54 min

  • Altare della Patria
  • Capitoline Hill
  • Roman Forum
  • Colosseum
  • Circus Maximus
  • More

On day 6 of your road trip, you will have an entire day to discover what to see in Rome. You’ll stay in Rome for 2 nights.

Rome is brimming with adventures.

One of the most locally renowned attractions included on the itinerary is Altare Della Patria. This historic monument will help you start your sightseeing on top. Then, take a leisurely stroll to Capitoline Hill and learn what makes this enchanting public square unique.

Throughout the day, make sure to take breaks to appreciate the surroundings. Next up, visit the wondrous Roman Forum. After exploring the archeological site, head to Colosseum. This wondrous archeological site is a highlight in Rome. As your day continues, stop by Circus Maximus, known for its picture-perfect features.

Don’t forget to check out all the popular tours and experiences you can add to your travel plans in Italy. You can explore and select activities under each day of your itinerary.

Rome is a place where the culinary landscape is as diverse as its attractions. So before the day ends, treat your palate to a taste of local cuisine at one of the best restaurants in Rome.

Savor the flavors at Hotel de Russie, a top pick for dinner tonight. Alternatively, La Taverna Italiana beckons with its unique menu offerings. Also, consider The Parrot Bar. With its consistent customer satisfaction, it’s an excellent option for dining in Rome tonight.

Following your dinner, dive into the local bar culture at The Apartment Bar Roma. Enjoy this evening's relaxed ambiance with delightful drinks. Alternatively, go to Hotel Hassler Roma, the perfect place for those looking to experience the best of the nightlife.

Take some time to reflect on your day and savor another beautiful night in Italy.

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Day 7

Day 7

  • Rome
  • More

Drive 6 km, 57 min

  • Castel Sant'Angelo
  • Piazza Navona
  • Pantheon
  • largo di Torre Argentina
  • Campo de' Fiori
  • More

Day 7 of your road trip across Italy promises a magnificent time exploring what to see in Rome. You have 1 night left in Rome. Take the opportunity to experience more of the best attractions and activities in the city.

Awaiting your discovery is the famous Castel Sant'angelo, a romantic castle in Rome. Next, go to Piazza Navona.

After visiting Castel Sant'angelo and Piazza Navona, have a stroll along Rome's streets and take in the local charm. Continue your sightseeing by heading to Pantheon. This heritage-rich monument offers a unique experience. Largo Di Torre Argentina is another noteworthy attraction worthwhile a visit. End your self-guided sightseeing tour on top with a visit to Campo De' Fiori, one of the most picture-perfect places to visit in Rome.

Don’t forget to check out all the popular tours and experiences you can add to your travel plans in Italy. You can explore and select activities under each day of your itinerary.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Rome, it's often a good idea to reserve a table in advance.

Enjoy a delicious meal at Sofitel Roma Villa Borghese, a top-rated dining destination in Rome. If you're in the mood to try something new, consider Centro, another top spot with a mouthwatering menu. You might also want to secure a reservation at Ristorante Tema. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Rome this evening.

Raise your glass to another unforgettable day in Italy!

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Day 8

Day 8

  • Rome
  • Naples
  • More

Drive 234 km, 2 hours 54 min

  • St Peter's Basilica
  • More

Your itinerary for day 8 of your road trip in Italy includes 1 stop and features some of the highlights of Vatican City. At the end of the day, enjoy the comforts of a top-rated hotel in Naples, where you'll spend 2 nights.

Look forward to a unique sightseeing adventure at the globally renowned St. Peter's Basilica and allow yourself time to explore.

At the end of the day, you will drive to Naples, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

Naples is a place where the culinary landscape is as diverse as its attractions. So before the day ends, treat your palate to a taste of local cuisine at one of the best restaurants in Naples.

Set out on a gastronomic journey in Naples by reserving a table at Veritas. Renowned for its 1-star Michelin recognition, this restaurant presents an outstanding menu of campanian and contemporary cuisine. For a different taste, head over to Il Comandante, renowned for its delectable creative and mediterranean dishes. This distinguished 1-star Michelin-recipient is a favorite among guests, making it a worthy addition to your holiday plans. Craving more culinary excitement? Explore ARIA, a highly rated local gem known for its exquisite contemporary and modern menu. With a 1-star Michelin acclaim, it promises a dining experience you won't want to miss. Known for great service, it’s a fantastic choice for tonight in Naples.

Let the evening flow smoothly from dinner to drinks at Happening Cocktail Bar, a top-rated bar in the area. For other recommendations, Shanti Art Musik Bar provides a perfect setting for rounding out your night with style and great drinks. Likewise, Gran Caffè Gambrinus offers a memorable night with diverse drink options and excellent service.

Relax and recharge in preparation for another adventurous day in Italy!

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Day 9

Day 9

  • Naples
  • More

Drive 129 km, 3 hours 30 min

  • Amalfi Coast
  • Naples National Archaeological Museum
  • Cappella Sansevero
  • Napoli Sotterranea Percorso Ufficiale
  • More

On day 9 of your road trip, you’ll start and end your day in Naples, where you still have 1 night left. You'll spend part of the day exploring places of interest outside the immediate city, including Amalfi and Naples.

Amalfi Coast is must-visit coast and a great option for a daytime tour of the area. Continue your journey to Naples National Archaeological Museum, a well-known museum, located just a leisurely stroll away. Next, head to Cappella Sansevero, an instagrammable museum, also available for your discovery today.

When you’re done exploring the area’s best attractions, you’ll drive back to your accommodation in Naples.

Naples is a place where the culinary landscape is as diverse as its attractions. So before the day ends, treat your palate to a taste of local cuisine at one of the best restaurants in Naples.

Have a fantastic dining experience at Antica Pizzeria Di Matteo, a highly recommended choice for tonight's dinner. If you're looking to mix things up, Mercure Napoli Centro Angioino offers an enticing alternative with its varied menu. Additionally, La Lazzara Trattoria e Pizzeria is worth considering. Renowned for satisfying diners, it’s an ideal option for tonight in Naples.

After your delicious meal, get a taste of the vibrant nightlife with a visit to Archivio Storico - Cocktail Bar & Wonderfood, known for its inviting atmosphere. Archeobar is another great option if you’re looking for a place to get the night started. Similarly, Babette Pub provides a great setting to enjoy the night away.

Get a good night's sleep and look forward to another great day on the road in Italy!

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Day 10

Day 10

  • Naples
  • Bari
  • More

Drive 270 km, 3 hours 34 min

  • piazza del Plebiscito
  • Ovo Castle
  • Porto di Trani
  • More

Experience an unparalleled adventure on day 10 of your road trip in Italy. This exciting part of your journey invites you to discover the renowned landmarks in 2 places, which are Naples and Trani. At the end of the day, you will retreat to the hotel of your choice in Bari, where will spend 1 night.

Piazza Del Plebiscito makes a great addition to your morning plans. This top-rated public square is a history-steeped place to see in Naples. Continue your discovery at Ovo Castle, a grand castle with stories to tell.

As you stroll around Naples, take in the distinct atmosphere and learn what makes this city so unique. Maximize your sightseeing with a visit to Porto Di Trani. This worthwhile marina offers a romantic encounter with Naples. Whether you decide to get entrance tickets for all attractions or you prefer admiring from a distance, amazing experiences await on this day in Naples.

When you’re done exploring for the day, you’ll drive to your hotel in Bari. Check in and relax before you head out to tour the city.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Bari. Enjoy a relaxing evening as you savor delicious local cuisine.

Savor the flavors at Fabulà Bari, a top pick for dinner tonight. Alternatively, AncheCinema beckons with its unique menu offerings. Also, consider La Tana del Polpo. With its consistent customer satisfaction, it’s an excellent option for dining in Bari tonight.

If you’re not ready to end the night just yet, Noise offers a perfect venue to relax and savor a drink. Similarly, Luau Tiki Bar is well-suited for those looking to unwind in a social setting. Mercantilenove is another excellent spot to enjoy a nightcap after a delightful meal.

Head back to your accommodation in Bari and get some rest to prepare for another magical day of your road trip in Italy.

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Day 11

Day 11

  • Bari
  • Brindisi
  • More

Drive 117 km, 2 hours 2 min

  • Palazzo Fizzarotti
  • Direzione regionale Musei
  • Basilica San Nicola
  • Basilica Cattedrale Metropolitana Primaziale San Sabino
  • More

On day 11 of your road trip in Italy, your travel plans include 1 stop at the most scenic, wondrous, and interesting places in the region. Bari are on today's agenda. In the evening, you’ll end up in Brindisi, where you will stay for 1 night.

Let Palazzo Fizzarotti set the tone for the day. Spend some time admiring this enchanting palace before continuing your journey. Direzione Regionale Musei is your next stop. This increasingly popular museum is one of the best-rated sights in Bari.

Consider grabbing some lunch or a light snack to keep your energy going. Beyond the above-mentioned attractions, today is also the perfect time to visit Basilica Di San Nicola. This culturally significant church is a sight to behold. To round off your sightseeing experience, visit Basilica Cattedrale Metropolitana Primaziale San Sabino.

After soaking up all the sights on today's itinerary, you'll be ready to head to your accommodation in Brindisi. Brindisi offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Brindisi. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Have a fantastic dining experience at Betty - Gelateria Cafe Ristorante Pizzeria a Brindisi, a highly recommended choice for tonight's dinner. If you're looking to mix things up, Bento offers an enticing alternative with its varied menu. Additionally, Cozza Nera is worth considering. Renowned for satisfying diners, it’s an ideal option for tonight in Brindisi.

As the sun sets, rest up and recharge for the next leg of your road trip in Italy.

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Day 12

Day 12

  • Brindisi - Departure day
  • More
  • Bersaglieri monument
  • More

Day 12 of your road trip in Italy is your departure day. This is your chance to catch a last glimpse of Brindisi before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

If you're up for some more sightseeing, begin at Bersaglieri Monument. This worthwhile monument is a hotspot among locals.

Before you conclude your road trip in Italy, drop by another restaurant for a last chance at a memorable dining experience in Brindisi.

Treat yourself to a delightful dinner at Rendez-Vous Cafè Bistrot, highly recommended for tonight's dining. Or, if you're feeling adventurous, why not try Pizzeria La Nassa? It's another excellent option with a diverse menu.

You’ll then say farewell to Brindisi. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Italy!

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Enjoy seamless planning
With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.
Explore with confidence
From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.
Secure your spot
Confirm your package instantly and lock in the best rate with secure payment and guaranteed availability.
Get instant confirmation
Shortly after booking, you’ll receive your full itinerary, including schedules, locations, and everything you need for a stress-free trip.
Personalize your itinerary
Each package includes a professionally crafted itinerary you can tailor to your travel style. A dedicated travel expert will make sure every detail fits your needs perfectly.
Easily make changes
Need to update plans? No problem. Whether before your trip or mid-journey, we’re just seconds away to help with quick adjustments.
Enjoy seamless planning
With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.
Explore with confidence
From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.

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