12-Day Italy Self-Drive Road Trip With Itinerary from Genoa to La Spezia, Florence, San Gimignano, Santa Maria degli Angeli, and Rome

On day 2 of your road trip, you will have an entire day to discover what to see in Genoa. You’ll stay in Genoa for 1 night.

Lighthouse Of Genoa is must-visit lighthouse and a great option for a daytime tour of the area. Continue your journey to Royal Palace Museum, an intriguing museum, located just a leisurely stroll away. Next, head to Via Garibaldi, an enchanting street, also available for your discovery today.

Each stop on today’s itinerary promises to leave you with lasting memories and a deeper appreciation for Genoa. When you're ready, let your sightseeing route take you to the often recommended Palazzo Podestà. If you’re looking for more, Aquarium Of Genoa is also a spectacular attraction that is worthwhile a visit. Lastly, don’t miss Porto Antico, a place of romantic interest in the city.

Don’t forget to check out all the popular tours and experiences you can add to your travel plans in Italy. You can explore and select activities under each day of your itinerary.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Genoa, it's often a good idea to reserve a table in advance.

Treat yourself to a delightful dinner at Zeffirino, highly recommended for tonight's dining. Or, if you're feeling adventurous, why not try Trattoria Vegia Zena? It's another excellent option with a diverse menu. Consider reserving a table at Trattoria delle Grazie as well. Known for its consistent customer satisfaction, it’s an ideal pick for tonight in Genoa.

Head back to your accommodation in Genoa and get some rest to prepare for another magical day of your road trip in Italy.

On day 3 of your road trip in Italy, your travel plans include 4 stops at the most scenic, wondrous, and interesting places in the region. Vernazza, Corniglia, Manarola, and Riomaggiore are on today's agenda. In the evening, you’ll end up in La Spezia, where you will stay for 1 night.

Vernazza’s wonders await as you prepare for another journey on the road, leaving the breathtaking surroundings of Genoa behind. This drive usually takes around 1 hour 49 min. Vernazza welcomes you with a multitude of unique vacation experiences.

One of our top recommendations for your sightseeing is Ruins Of Doria Tower. Spend some time admiring the enchanting features of the monument before you continue to your next stop. Then, head to Church Of St. Margaret Of Antioch. This curiosity-inducing church is a traveler-favorite in the village.

Embrace the thrill of the open road as you wave goodbye to Vernazza and set your GPS to Corniglia. While on the road, immerse yourself in your favorite road trip tunes or sample the sounds from a local radio station. This car ride usually takes around 14 min. Upon reaching Corniglia, unwind, observe, and explore. The best things to do, see, and eat are waiting for you.

Spend your afternoon discovering Cinque Terre National Park, a notable national park known for its eye-catching features.

When you’re ready to jump back into the car and say goodbye to Corniglia, you’ll hit the road in the direction of Manarola. This drive usually takes around 15 min.

Our first attraction recommendation in Manarola is Manarola Overlook Viewpoint, an intriguing observation deck that draws attention for its mesmerizing features.

When you’re done exploring for the day, you’ll drive to your hotel in La Spezia. Check in and relax before you head out to tour the city.

After a day of adventure, treat yourself to an exquisite dinner at one of La Spezia's best restaurants.

Make sure to reserve a table at The Colombaio Park, an iconic dining spot in La Spezia. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world.

Celebrate another amazing day of your road trip adventure in Italy!

On day 4 of your exciting self-drive vacation in Italy, you’ll soak in the magnificence of 1 destination, including Pisa. When you’re not sightseeing, take time to relax at your chosen hotel in Florence, where you’ll be staying for 2 nights.

Throughout the day, make sure to take breaks to appreciate the surroundings.

Fasten your seatbelt and make your way to your next stop — Pisa, home to many well-known sights in the region. Keep in mind that your travel time from La Spezia to Pisa may take around 1 hour 5 min without traffic disruptions. Upon arrival in Pisa, we highly recommend checking out some of the top attractions.

For a more meaningful self-guided tour of the city's best attractions, visit Santa Maria Della Spina, an often recommended church that is sure to impress. Take in the surroundings and enjoy the freedom of exploring at your own pace before you continue your journey. Next, head to Palazzo Blu and admire its photogenic features.

When you’re ready, continue to Knights' Square, a locally appreciated public square beloved by locals and tourists alike. Don't miss out on Leaning Tower Of Pisa, another highlight of the area that promises a memorable visit. Not far away, you’ll also find Piazza Del Duomo, Pisa, a historic place to see that you won’t regret spending some extra time discovering.

After soaking up all the sights on today's itinerary, you'll be ready to head to your accommodation in Florence. Florence offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

Indulge in a memorable dining experience at one of Florence's most popular restaurants, and connect with friendly locals for a true cultural experience.

Treat yourself to a wonderful meal at Ristorante Oliviero 1962, a top-rated dining spot in Florence. If you're in the mood for something new, try Di Poneta Novoli, another premier location with a delectable menu. You might also want to book a table at Caffe San Firenze. Known for its consistently satisfied patrons, it’s a perfect choice to elevate your evening in Florence.

Cap off your culinary experience with a visit to some of the most celebrated bars in the area. For instance, Manifattura stands out as an excellent choice for a post-dinner cocktail. Alternatively, Se·sto On Arno Rooftop Bar offers an ideal atmosphere to enjoy the pleasures of the night. Il Vinile is also a great option that provides a perfect setting for a relaxing evening.

Get a good night's sleep and look forward to another great day on the road in Italy!

Day 5 offers an itinerary packed with the best things to see in Genoa. You’ll stay in Florence for 1 night more, offering you enough time to explore at a relaxed pace.

Whether you decide to explore Florence on foot, use public transport, or join a guided tour, there are a few attractions you don’t want to miss.

Your adventure in Florence is only getting started when you visit Cathedral Of Santa Maria Del Fiore, a widely recognized local hot spot. Another notable attraction to explore is Piazza Della Signoria. This top-rated public square is known for its enchanting appeal.

After soaking in the highlights of these sights, take some time to wander Florence's streets and immerse yourself in the local atmosphere. When you're ready to continue your sightseeing adventure, head to Palazzo Vecchio. This history-steeped palace offers a fascinating experience that many visitors find memorable. Ponte Vecchio is also worth visiting, along with Uffizi Gallery. These standout landmarks offer unique experiences that add to the day’s enjoyment. End your day at Basilica Of Santa Croce In Florence. This popular church provides a fitting finale to your sightseeing.

Don’t forget to check out all the popular tours and experiences you can add to your travel plans in Italy. You can explore and select activities under each day of your itinerary.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Florence. Enjoy a relaxing evening as you savor delicious local cuisine.

Savor the flavors at Ditta Artigianale, a top pick for dinner tonight. Alternatively, Trattoria Da Burde beckons with its unique menu offerings. Also, consider Casa Toscana. With its consistent customer satisfaction, it’s an excellent option for dining in Florence tonight.

After your meal, keep the night alive at a bar like Bar 50 Rosso, known for its lively atmosphere. Bitter Bar is another top recommendation that provides the perfect setting with well-crafted drinks and a welcoming ambiance. Similarly, Archea Brewery offers an excellent atmosphere for those looking to amp up the evening.

Celebrate another amazing day of your road trip adventure in Italy!

Dive into day 6 of your remarkable road trip in Italy. Today you'll explore 2 destinations, including Siena and San Gimignano. At the end of the day, you’ll unwind at one of the finest accommodations in San Gimignano, where you'll spend 2 nights.

When you’ve had your share of Florence, prepare for your next destination. Admire the views and listen to some good music as you drive in the direction of Siena. Your travel time is around 1 hour 8 min.

When you're ready for some sights, head to Basilica Of San Domenico, an increasingly popular church in Siena. Explore its stunning features at your own pace before you continue your journey to your next attraction, Piazza Del Campo. This extraordinary public square is a top recommendation in the area.

When you’re ready to explore more, Tower Of Mangia is an excellent choice. Spend some time discovering what some claim to be the most UNESCO world heritage-designated monument in the region. Next, continue your sightseeing at the locally renowned Siena Cathedral and discover what makes this church unique. If you’re up for one more stop in the city, head to Piccolomini Library, an instagrammable library many travelers find the visit worthwhile.

When you’re ready to jump back into the car and say goodbye to Siena, you’ll hit the road in the direction of San Gimignano. This drive usually takes around 43 min.

Our first attraction recommendation in San Gimignano is Porta San Giovanni, an increasingly popular monument that draws attention for its culturally significant features.

At the end of the day, you will drive to San Gimignano, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in San Gimignano. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Savor another day of unforgettable experiences in Italy!

Day 7 of your road trip will take you to the best attractions San Gimignano has to offer. Cherish the 1 night you have left in the village and use the provided itinerary to discover what to see in San Gimignano.

To truly experience San Gimignano, make sure to drop by Piazza Del Duomo. This increasingly popular public square is a must-visit for anyone seeking a unique vacation experience. Another sight you shouldn’t miss is Palazzo Comunale, Pinacoteca, Torre Grossa, one of the village’s best highlights.

Next, check out Sangimignano1300, one of the most up-and-coming places to see in San Gimignano. This museum is a favorite among locals and travelers alike. Enjoy some downtime and refreshments before continuing to your next stop, Parco Della Rocca. Wander around and soak in the history-steeped atmosphere this park offers. Then, head to Rocca Di Montestaffoli, a top-rated castle that adds another dimension to your day. Finally, visit the curiosity-inducing Chiesa Di Sant'agostino, the last of our attraction recommendations for today.

Don’t forget to check out all the popular tours and experiences you can add to your travel plans in Italy. You can explore and select activities under each day of your itinerary.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in San Gimignano. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Raise your glass and celebrate another amazing day of your road trip in Italy!

Experience an unparalleled adventure on day 8 of your road trip in Italy. This exciting part of your journey invites you to discover the renowned landmarks in 1 place, which are Santa Maria degli Angeli. At the end of the day, you will retreat to the hotel of your choice in Santa Maria degli Angeli, where will spend 1 night.

Once you're ready to continue your road trip, it's time to buckle up and drive, eagerly anticipating your arrival in Santa Maria degli Angeli. This drive usually takes around 2 hours 2 min, without any stops or traffic disruptions.

Set out on a self-guided sightseeing tour at Basilica Of Santa Maria Degli Angeli and explore the stunning features.

It’s time to gear up for the next part of your road trip adventure. Under favorable conditions, your drive to Santa Maria degli Angeli may take around 9 min. Upon your arrival in Santa Maria degli Angeli, you’ll be greeted with the opportunity to do some sightseeing and exploring.

For a more meaningful self-guided tour of the village's best attractions, visit Basilica Of San Francesco D'assisi, a captivating church that is sure to impress. Take in the surroundings and enjoy the freedom of exploring at your own pace before you continue your journey.

When you’re ready, continue to Portico Of Monte Frumentario, a frequently visited historical landmark beloved by locals and tourists alike. Don't miss out on Rocca Maggiore, another highlight of the area that promises a memorable visit. Not far away, you’ll also find Piazza Del Comune, an UNESCO world heritage-listed place to see that you won’t regret spending some extra time discovering.

When you’re done exploring for the day, you’ll drive to your hotel in Santa Maria degli Angeli. Check in and relax before you head out to tour the town.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Santa Maria degli Angeli. Enjoy a relaxing evening as you savor delicious local cuisine.

Following your dinner, dive into the local bar culture at Bibenda Assisi Wine Tasting & Gourmet Food, Olive Oil And Chocolate Tastings. Enjoy this evening's relaxed ambiance with delightful drinks.

As the sun sets, rest up and recharge for the next leg of your road trip in Italy.

Your itinerary for day 9 of your road trip in Italy includes 1 stop and features some of the highlights of Rome. At the end of the day, enjoy the comforts of a top-rated hotel in Rome, where you'll spend 2 nights.

When you’re ready to jump back into the car and say goodbye to Santa Maria degli Angeli, you’ll hit the road in the direction of Rome. This drive usually takes around 2 hours 25 min.

Spend your afternoon discovering Colosseum, a timeless archeological site known for its historic features. Next, continue your sightseeing at Roman Forum, a timeless archeological site.

If you're starting to feel hungry, this is a great time for a break at a nearby restaurant or cafe. When you're ready for more, stop by Pantheon and uncover the details of this culturally significant monument. Make sure to also explore Piazza Di Spagna, a world-famous public square. For your last stop, consider Piazza Del Popolo, a visually striking public square that many travelers find worth the detour.

After soaking up all the sights on today's itinerary, you'll be ready to head to your accommodation in Rome. Rome offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

Rome is a place where the culinary landscape is as diverse as its attractions. So before the day ends, treat your palate to a taste of local cuisine at one of the best restaurants in Rome.

Don’t miss out on dining at La Bottega Roma, a top-rated dining destination in Rome. If you're in the mood to try something new, consider Pasta In Corso, another top spot with a mouthwatering menu. You might also want to secure a reservation at Trattoria Vecchia Roma. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Rome this evening.

Continue your lively evening at La Botticella Of Poggi Giovanni, a perfect place for winding down or revving up the night, depending on which mood you’re in. Almalu Trastevere is another excellent bar that offers a great selection of drinks to suit any mood. If you prefer to go somewhere else, Bar Viminale Di Pepi Maurilio ensures a night out tailored to your taste.

Raise your glass to another unforgettable day in Italy!

Greet day 10 of your road trip in Italy with a smile and start your day with a hearty breakfast. You have 1 night to stay in Rome, so get ready to make the most of your time in the region. On the agenda for this day, you’ll find only the best things to see and do in Vatican City and Rome.

Make a stop at Castel Sant'angelo. This spectacular castle is a must-visit for travelers looking for a unique holiday experience. Make your way to Piazza Navona located in Rome for another exciting encounter.

Next, immerse yourself in the setting of Trevi Fountain. Its romantic features will captivate you.

Set your GPS to Vatican City, Vatican City and hit the road. Expect a journey of approximately 12 min without stops. Soak in the beautiful landscapes as you drive and look forward to exploring your next destination. Vatican City beckons with new experiences!

One of our top recommendations for your sightseeing is Vatican Museums. Then, head to St. Peter's Basilica. This globally renowned major basilica is a traveler-favorite in the city.

If you're keen to see more, continue to Sistine Chapel. Feed your curiosity by learning something new about the chapel.

When you’re done exploring the area’s best attractions, you’ll drive back to your accommodation in Rome.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Rome. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Make sure to reserve a table at RomAntica, an iconic dining spot in Rome. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Coso Ristorante, a popular restaurant in Rome. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of DEROMA - Farine Romane, a hidden gem nestled in Rome. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

If you’re not ready to end the night just yet, Sant' Eustachio Caffè offers a perfect venue to relax and savor a drink. Similarly, Yellowsquare Rome is well-suited for those looking to unwind in a social setting. Caffè Portofino is another excellent spot to enjoy a nightcap after a delightful meal.

Celebrate another amazing day of your road trip adventure in Italy!

On day 11 of your road trip in Italy, your travel plans include 1 stop at the most scenic, wondrous, and interesting places in the region. Orvieto are on today's agenda. In the evening, you’ll end up in Genoa, where you will stay for 1 night.

Set your GPS to Orvieto and hit the road. Expect a journey of approximately 1 hour 35 min without stops. Soak in the beautiful landscapes as you drive and look forward to exploring your next destination. Orvieto beckons with new experiences!

Enjoy sightseeing at your own pace and allow yourself time to explore the beautiful surroundings. Take your self-guided tour to Well Of St. Patrick, a locally renowned monument that everyone visiting Orvieto should see.

Orvieto’s wonders await as you prepare for another journey on the road, leaving the breathtaking surroundings of Rome behind. This drive usually takes around 1 hour 35 min. Orvieto welcomes you with a multitude of unique vacation experiences.

Enjoy sightseeing at your own pace and allow yourself time to explore the beautiful surroundings. Take your self-guided tour to Orvieto Cathedral, a captivating church that everyone visiting Orvieto should see. Next, head to Orvieto Underground. This heritage-rich cave system is one of the most frequently visited attractions in the region.

If you're keen to see more, don’t miss out on Torre Del Moro Orvieto, a historic monument popular among locals as well as travelers. Pozzo Della Cava is an excellent attraction to visit next. Spend some time learning more about this locally appreciated cave before you continue your journey.

At the end of the day, you will drive to Genoa, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Genoa, it's often a good idea to reserve a table in advance.

Enjoy a lovely meal at Osteria Sant'Ilario, a top-rated place to have dinner tonight. Alternatively, if your taste buds call for something different, La Cialtroneria is another top choice with a popular menu. You could also check for a table at Manhattan Bar. As an establishment that consistently gains high praises from customers, it’s an ideal choice in Genoa tonight.

Say good night to Genoa and look forward to another great day of your road trip in Italy!