12-Day Italy Self-Drive Road Trip With Itinerary from Genoa to La Spezia, Florence, San Gimignano, Santa Maria degli Angeli, and Rome

Day 2 offers an itinerary packed with the best things to see in Genoa. You’ll stay in Genoa for 1 night more, offering you enough time to explore at a relaxed pace.

Don’t forget to check out all the popular tours and experiences you can add to your travel plans in Italy. You can explore and select activities under each day of your itinerary.

Bring home unique finds from Genoa's bustling shopping hub, Via Garibaldi. Enjoy a leisurely exploration of unique stores where locals shop. Don’t forget to browse souvenirs and local specialties that make perfect gifts for your loved ones. Beyond shopping, Via Garibaldi offers plenty of options, including primary services, unique landmarks, and community events.

After a day of adventure, treat yourself to an exquisite dinner at one of Genoa's best restaurants.

Head back to your accommodation in Genoa and get some rest to prepare for another magical day of your road trip in Italy.

On day 3 of your road trip in Italy, your travel plans include 4 stops at the most scenic, wondrous, and interesting places in the region. Vernazza, Corniglia, Manarola, and Riomaggiore are on today's agenda. In the evening, you’ll end up in La Spezia, where you will stay for 1 night.

After soaking up all the sights on today's itinerary, you'll be ready to head to your accommodation in La Spezia. La Spezia offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in La Spezia. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Head back to your accommodation in La Spezia and get some rest to prepare for another magical day of your road trip in Italy.

Dive into day 4 of your remarkable road trip in Italy. Today you'll explore 1 destination, including Pisa. At the end of the day, you’ll unwind at one of the finest accommodations in Florence, where you'll spend 2 nights.

When you’re done exploring for the day, you’ll drive to your hotel in Florence. Check in and relax before you head out to tour the city.

Florence is a place where the culinary landscape is as diverse as its attractions. So before the day ends, treat your palate to a taste of local cuisine at one of the best restaurants in Florence.

As the day draws to a close, take a moment to unwind and prepare for the next exciting chapter of your road trip in Italy.

You have 1 night left in Florence. Take the opportunity to experience more of the best attractions and activities in the city.

Don’t forget to check out all the popular tours and experiences you can add to your travel plans in Italy. You can explore and select activities under each day of your itinerary.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Florence. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Relax and look forward to more memorable moments to come!

On day 6 of your exciting self-drive vacation in Italy, you’ll soak in the magnificence of 2 destinations, including Siena and San Gimignano. When you’re not sightseeing, take time to relax at your chosen hotel in San Gimignano, where you’ll be staying for 2 nights.

At the end of the day, you will drive to San Gimignano, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

After a day of adventure, treat yourself to an exquisite dinner at one of San Gimignano's best restaurants.

Take some time to reflect on your day and savor another beautiful night in Italy.

You’ll stay in San Gimignano for 1 night.

Don’t forget to check out all the popular tours and experiences you can add to your travel plans in Italy. You can explore and select activities under each day of your itinerary.

San Gimignano is a place where the culinary landscape is as diverse as its attractions. So before the day ends, treat your palate to a taste of local cuisine at one of the best restaurants in San Gimignano.

As the sun sets, rest up and recharge for the next leg of your road trip in Italy.

Your itinerary for day 8 of your road trip in Italy includes 1 stop and features some of the highlights of Santa Maria degli Angeli. At the end of the day, enjoy the comforts of a top-rated hotel in Santa Maria degli Angeli, where you'll spend 1 night.

After soaking up all the sights on today's itinerary, you'll be ready to head to your accommodation in Santa Maria degli Angeli. Santa Maria degli Angeli offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Santa Maria degli Angeli, it's often a good idea to reserve a table in advance.

Raise your glass and celebrate another amazing day of your road trip in Italy!

Experience an unparalleled adventure on day 9 of your road trip in Italy. This exciting part of your journey invites you to discover the renowned landmarks in 1 place, which are Rome. At the end of the day, you will retreat to the hotel of your choice in Rome, where will spend 2 nights.

When you’re done exploring for the day, you’ll drive to your hotel in Rome. Check in and relax before you head out to tour the city.

Indulge in a memorable dining experience at one of Rome's most popular restaurants, and connect with friendly locals for a true cultural experience.

Relax and recharge in preparation for another adventurous day in Italy!

Wake up to day 10 of your road trip in Italy. On this day, you’ll embark on an exciting expedition discovering the enchanting sights and activities of Vatican City and Rome. With 1 night to stay in Rome, we encourage you to seize the day and discover the unexplored beauty of the city’s surroundings!

When you’re done exploring the area’s best attractions, you’ll drive back to your accommodation in Rome.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Rome. Enjoy a satisfying meal that will recharge you for tonight's adventures.

As the day draws to a close, take a moment to unwind and prepare for the next exciting chapter of your road trip in Italy.

On day 11 of your road trip in Italy, your travel plans include 1 stop at the most scenic, wondrous, and interesting places in the region. Orvieto are on today's agenda. In the evening, you’ll end up in Genoa, where you will stay for 1 night.

At the end of the day, you will drive to Genoa, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Genoa. Enjoy a relaxing evening as you savor delicious local cuisine.

As the sun sets, rest up and recharge for the next leg of your road trip in Italy.