12-Day Italy Self-Drive Road Trip With Itinerary from Genoa to La Spezia, Florence, San Gimignano, Santa Maria degli Angeli, and Rome

On day 2 of your road trip, you will have an entire day to discover what to see in Genoa. You’ll stay in Genoa for 1 night.

To truly experience Genoa, make sure to drop by Lighthouse Of Genoa. This often recommended lighthouse is a must-visit for anyone seeking a unique vacation experience. Another sight you shouldn’t miss is Royal Palace Museum, one of the city’s best highlights.

Next, check out Via Garibaldi, one of the most increasingly popular places to see in Genoa. This street is a favorite among locals and travelers alike. Enjoy some downtime and refreshments before continuing to your next stop, Palazzo Podestà. Wander around and soak in the visually striking atmosphere this palace offers. Then, head to Aquarium Of Genoa, a top-rated aquarium that adds another dimension to your day. Finally, visit the well-known Porto Antico, the last of our attraction recommendations for today.

Don’t forget to check out all the popular tours and experiences you can add to your travel plans in Italy. You can explore and select activities under each day of your itinerary.

Bring home unique finds from Genoa's bustling shopping hub, Via XX Settembre. Enjoy a leisurely exploration of unique stores where locals shop. Don’t forget to browse souvenirs and local specialties that make perfect gifts for your loved ones. Beyond shopping, Via XX Settembre offers plenty of options, including restaurants, primary services, unique landmarks, and community events.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Genoa. Enjoy a relaxing evening as you savor delicious local cuisine.

Treat yourself to a delicious dinner at Zeffirino, an excellent option for tonight's dining. Looking for something different? Trattoria Vegia Zena offers a tantalizing alternative with its diverse menu. And don’t miss Trattoria delle Grazie. Known for great service, it’s a fantastic choice for tonight in Genoa.

Say good night to Genoa and look forward to another great day of your road trip in Italy!

On day 3 of your road trip in Italy, your travel plans include 4 stops at the most scenic, wondrous, and interesting places in the region. Vernazza, Corniglia, Manarola, and Riomaggiore are on today's agenda. In the evening, you’ll end up in La Spezia, where you will stay for 1 night.

Catch Ruins Of Doria Tower before the crowds roll in. This respected monument is sure to ignite your curiosity. Next, dive into the standout features of Church Of St. Margaret Of Antioch, a must-visit church in the village.

In between sights, stop by local stores, picturesque photo spots, and small eateries. When you’re ready for your next attraction, proceed to Cinque Terre National Park, a captivating national park. For a change of scene, check out Manarola Overlook Viewpoint, known for its mesmerizing features. We also recommend visiting Riomaggiore. This sightseeing destination is a must for anyone looking to experience the village to the fullest. Lastly, end your day with a visit to Church Of San Giovanni Battista Of Riomaggiore, yet another up-and-coming attraction in Genoa.

When you’re done exploring for the day, you’ll drive to your hotel in La Spezia. Check in and relax before you head out to tour the city.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in La Spezia. Enjoy a relaxing evening as you savor delicious local cuisine.

Enjoy a delicious meal at The Colombaio Park, a highly-rated dining destination in La Spezia.

Savor another day of unforgettable experiences in Italy!

Your itinerary for day 4 of your road trip in Italy includes 1 stop and features some of the highlights of Pisa. At the end of the day, enjoy the comforts of a top-rated hotel in Florence, where you'll spend 2 nights.

Let Santa Maria Della Spina set the tone for the day. Spend some time admiring this romantic church before continuing your journey. Palazzo Blu is your next stop. This up-and-coming art gallery is one of the best-rated sights in La Spezia.

Consider grabbing some lunch or a light snack to keep your energy going. Beyond the above-mentioned attractions, today is also the perfect time to visit Knights' Square. This picture-perfect public square is a sight to behold. To round off your sightseeing experience, visit Leaning Tower Of Pisa and Piazza Del Duomo, Pisa. If time allows, end your day with Pisa Cathedral, a picture-perfect church that offers a memorable conclusion to your exploration.

At the end of the day, you will drive to Florence, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

Indulge in a memorable dining experience at one of Florence's most popular restaurants, and connect with friendly locals for a true cultural experience.

Have a fantastic dining experience at Ristorante Oliviero 1962, a highly recommended choice for tonight's dinner. If you're looking to mix things up, Di Poneta Novoli offers an enticing alternative with its varied menu. Additionally, Caffe San Firenze is worth considering. Renowned for satisfying diners, it’s an ideal option for tonight in Florence.

Keep the evening going at Manifattura, a great choice for enjoying the after-dinner hours with a drink. You could also go to Se·sto On Arno Rooftop Bar, which offers a similarly pleasant setting and great drinks. Another option is Il Vinile, which provides an inviting environment for unwinding after a busy day out.

As the sun sets, rest up and recharge for the next leg of your road trip in Italy.

Day 5 of your road trip across Italy promises a magnificent time exploring what to see in Florence. You have 1 night left in Florence. Take the opportunity to experience more of the best attractions and activities in the city.

Florence is brimming with adventures.

Enjoy all that Cathedral Of Santa Maria Del Fiore has to offer. This is an astonishing church you should not miss. Another must-see is Piazza Della Signoria, a spectacular public square in Florence.

When you’re ready for the next sight, head to Palazzo Vecchio. From there, take a leisurely stroll to Ponte Vecchio, another of the city’s timeless attractions. We recommend continuing your self-guided tour at Uffizi Gallery, an instagrammable place of interest in the city. If time allows, add Basilica Of Santa Croce In Florence to your itinerary. This well-known church offers the perfect finishing touch to your day in Florence.

Don’t forget to check out all the popular tours and experiences you can add to your travel plans in Italy. You can explore and select activities under each day of your itinerary.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Florence, it's often a good idea to reserve a table in advance.

Enjoy a lovely dining experience at Ditta Artigianale, a popular restaurant in Florence. This acclaimed establishment has earned the admiration of countless food lovers in the city. Alternatively, experience a taste of Florence at Trattoria Da Burde, another great place to eat. With a menu designed to impress, it promises a journey of flavors that will leave you captivated. A third option to check out is the top-rated Casa Toscana. It’s yet another ideal choice to enhance your time in Florence tonight.

Following your dinner, dive into the local bar culture at Bar 50 Rosso. Enjoy this evening's relaxed ambiance with delightful drinks. Alternatively, go to Bitter Bar, the perfect place for those looking to experience the best of the nightlife. Similarly, Archea Brewery provides excellent drinks and a great atmosphere, ensuring a memorable night out.

Raise your glass and celebrate another amazing day of your road trip in Italy!

On day 6 of your exciting self-drive vacation in Italy, you’ll soak in the magnificence of 2 destinations, including Siena and San Gimignano. When you’re not sightseeing, take time to relax at your chosen hotel in San Gimignano, where you’ll be staying for 2 nights.

To truly experience Florence, make sure to drop by Basilica Of San Domenico. This worthwhile church is a must-visit for anyone seeking a unique vacation experience. Another sight you shouldn’t miss is Piazza Del Campo, one of the city’s best highlights.

Next, check out Tower Of Mangia, one of the most locally appreciated places to see in Florence. This monument is a favorite among locals and travelers alike. Enjoy some downtime and refreshments before continuing to your next stop, Siena Cathedral. Wander around and soak in the inviting atmosphere this church offers. Then, head to Piccolomini Library, a top-rated library that adds another dimension to your day. Finally, visit the beloved Porta San Giovanni, the last of our attraction recommendations for today.

After soaking up all the sights on today's itinerary, you'll be ready to head to your accommodation in San Gimignano. San Gimignano offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in San Gimignano. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Raise your glass to another unforgettable day in Italy!

Day 7 of your road trip will take you to the best attractions San Gimignano has to offer. Cherish the 1 night you have left in the village and use the provided itinerary to discover what to see in San Gimignano.

Check out the beloved public square, Piazza Del Duomo. Afterward, continue to Palazzo Comunale, Pinacoteca, Torre Grossa, a museum every traveler should visit. As you explore San Gimignano’s charming streets, take in the lively atmosphere and get to know the character of the village.

Next, make your way to Sangimignano1300. This increasingly popular museum is an essential stop. Following that, head to Parco Della Rocca, another must-visit site that will enhance your experience. Don’t forget to stop by Rocca Di Montestaffoli, an underrated castle in the village. Finally, end your day with a visit to Chiesa Di Sant'agostino, a culturally significant church that offers the perfect conclusion to your sightseeing of the day.

Don’t forget to check out all the popular tours and experiences you can add to your travel plans in Italy. You can explore and select activities under each day of your itinerary.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in San Gimignano. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Head back to your accommodation in San Gimignano and get some rest to prepare for another magical day of your road trip in Italy.

Experience an unparalleled adventure on day 8 of your road trip in Italy. This exciting part of your journey invites you to discover the renowned landmarks in 1 place, which are Santa Maria degli Angeli. At the end of the day, you will retreat to the hotel of your choice in Santa Maria degli Angeli, where will spend 1 night.

Look forward to a unique sightseeing adventure at the captivating Basilica Of Santa Maria Degli Angeli and allow yourself time to explore. Just a short distance away you'll find your next stop, Basilica Of San Francesco D'assisi, a picture-perfect church that draws visitors from far and near.

Continue your journey to Porta San Giacomo, one of the village’s most locally appreciated spots that you shouldn’t miss. Another great site to visit is the frequently visited Portico Of Monte Frumentario. When you're finished at the historical landmark, Rocca Maggiore awaits your visit. This castle is a symbolic highlight on today's itinerary. Last up is a public square - the beloved Piazza Del Comune.

When you’re done exploring for the day, you’ll drive to your hotel in Santa Maria degli Angeli. Check in and relax before you head out to tour the town.

After a day of adventure, treat yourself to an exquisite dinner at one of Santa Maria degli Angeli's best restaurants.

Explore the vibrant nightlife at Bibenda Assisi Wine Tasting & Gourmet Food, Olive Oil And Chocolate Tastings after your meal, a hub for lively evenings and memorable moments.

Say good night to Santa Maria degli Angeli and look forward to another great day of your road trip in Italy!

Dive into day 9 of your remarkable road trip in Italy. Today you'll explore 1 destination, including Rome. At the end of the day, you’ll unwind at one of the finest accommodations in Rome, where you'll spend 2 nights.

Colosseum is an ideal stop early in the day. This timeless archeological site is a must-visit in the city. When you’re ready for your next discovery, continue to Roman Forum, which may be one of the most breathtaking places you will experience today.

One of the best things about exploring Santa Maria degli Angeli on a self-guided tour is that you set the pace. There’s plenty of time for detours and discovering hidden gems. When you’re ready for your next stop, make your way to Pantheon, a timeless monument in the city. If you’re up for more discoveries, don’t forget to reserve some time for Piazza Di Spagna and Piazza Del Popolo.

At the end of the day, you will drive to Rome, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

Rome is a place where the culinary landscape is as diverse as its attractions. So before the day ends, treat your palate to a taste of local cuisine at one of the best restaurants in Rome.

Make sure to reserve a table at La Bottega Roma, an iconic dining spot in Rome. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Pasta In Corso, a popular restaurant in Rome. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of Trattoria Vecchia Roma, a hidden gem nestled in Rome. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

Following your dinner, dive into the local bar culture at La Botticella Of Poggi Giovanni. Enjoy this evening's relaxed ambiance with delightful drinks. Alternatively, go to Almalu Trastevere, the perfect place for those looking to experience the best of the nightlife. Similarly, Bar Viminale Di Pepi Maurilio provides excellent drinks and a great atmosphere, ensuring a memorable night out.

Relax and look forward to more memorable moments to come!

Greet day 10 of your road trip in Italy with a smile and start your day with a hearty breakfast. You have 1 night to stay in Rome, so get ready to make the most of your time in the region. On the agenda for this day, you’ll find only the best things to see and do in Vatican City and Rome.

Enjoy all that Vatican Museums has to offer. This is a globally renowned art museum you should not miss. Another must-see is St. Peter's Basilica, a timeless major basilica in Rome.

When you’re ready for the next sight, head to Sistine Chapel. From there, take a leisurely stroll to Castel Sant'angelo, another of the city’s impressive attractions. We recommend continuing your self-guided tour at Piazza Navona, a history-steeped place of interest in the city. If time allows, add Trevi Fountain to your itinerary. This globally renowned monument offers the perfect finishing touch to your day in Rome.

When you’re done exploring the area’s best attractions, you’ll drive back to your accommodation in Rome.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Rome, it's often a good idea to reserve a table in advance.

Have a fantastic dining experience at RomAntica, a highly recommended choice for tonight's dinner. If you're looking to mix things up, Coso Ristorante offers an enticing alternative with its varied menu. Additionally, DEROMA - Farine Romane is worth considering. Renowned for satisfying diners, it’s an ideal option for tonight in Rome.

Following your dinner, dive into the local bar culture at Sant' Eustachio Caffè. Enjoy this evening's relaxed ambiance with delightful drinks. Alternatively, go to Yellowsquare Rome, the perfect place for those looking to experience the best of the nightlife. Similarly, Caffè Portofino provides excellent drinks and a great atmosphere, ensuring a memorable night out.

Raise your glass to another unforgettable day in Italy!

On day 11 of your road trip in Italy, your travel plans include 1 stop at the most scenic, wondrous, and interesting places in the region. Orvieto are on today's agenda. In the evening, you’ll end up in Genoa, where you will stay for 1 night.

Well Of St. Patrick makes a great addition to your morning plans. This captivating monument is a stunning place to see in Rome. Continue your discovery at Orvieto Cathedral, an inviting church with stories to tell.

As you stroll around Rome, take in the distinct atmosphere and learn what makes this village so unique. Maximize your sightseeing with a visit to Orvieto Underground. This up-and-coming cave system offers an eye-catching encounter with Rome. Next, make your way to Torre Del Moro Orvieto to add another highlight to your day. After that, visit Pozzo Della Cava, a locally appreciated cave that’s sure to impress. Whether you decide to get entrance tickets for all attractions or you prefer admiring from a distance, amazing experiences await on this day in Rome.

After soaking up all the sights on today's itinerary, you'll be ready to head to your accommodation in Genoa. Genoa offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Genoa, it's often a good idea to reserve a table in advance.

Enjoy a lovely meal at Osteria Sant'Ilario, a top-rated place to have dinner tonight. Alternatively, if your taste buds call for something different, La Cialtroneria is another top choice with a popular menu. You could also check for a table at Manhattan Bar. As an establishment that consistently gains high praises from customers, it’s an ideal choice in Genoa tonight.

Celebrate another amazing day of your road trip adventure in Italy!