12-Day Italy Self-Drive Road Trip With Itinerary from Naples traveling north to Viterbo, Florence, Siena, Rome, and Salerno

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Description

Escape the ordinary with this exciting 12-day road trip through Italy. Explore diverse landscapes, discover lively cities, and prepare for an unforgettable journey!

This perfectly planned road trip itinerary takes you through some of the best places to see in Italy. You will spend 3 nights in Naples, 1 night in Viterbo, 2 nights in Florence, 1 night in Siena, 3 nights in Rome, and 1 night in Salerno. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Italy. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have you covered.

Upon arriving in Naples, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Italy on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Italy. Trevi Fountain and Colosseum are just a couple of the bucket-list attractions that await your discovery.

As you hit the open road and drive through Naples, Tivoli, Viterbo, Orvieto, Florence, Pisa, Siena, Rome, Salerno, Amalfi, and Pompei, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Italy. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Italy.

Throughout your road trip in Italy, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Italy.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodations, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in Italy fill up quickly, so book your spot early. Select a date and start planning your road trip in Italy today!

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Driver’s age is 30 - 65
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Pick-up: 10:00
Drop-off: 10:00

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Day 1

Day 1

  • Naples - Arrival day
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  • piazza del Plebiscito
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Your road trip adventure in Italy begins as soon as you reach Naples and pick up your car. You’ll stay here for 2 nights and explore what to see in Naples, sample the local cuisine, and choose from a curated selection of the best hotels and places to stay in the city.

Naples is a beautiful city with plenty to discover. Taking a stroll in the city center is a great alternative. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

Find your way to your hotel in Naples. We recommend choosing a hotel in a central location for easy exploring. Check-in typically starts between 2 and 4 PM at hotels in Italy. Settle in and make plans for the evening.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Naples, it's often a good idea to reserve a table in advance.

Raise a toast to the start of your 12-day road trip in Italy!

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Day 2

Day 2

  • Naples
  • More

Drive 6 km, 45 min

  • Chiesa del Gesù Nuovo
  • Cappella Sansevero
  • Napoli Sotterranea Percorso Ufficiale
  • Cattedrale di Santa Maria Assunta
  • More

Day 2 offers an itinerary packed with the best things to see in Naples. You’ll stay in Naples for 1 night more, offering you enough time to explore at a relaxed pace.

Don’t forget to check out all the popular tours and experiences you can add to your travel plans in Italy. You can explore and select activities under each day of your itinerary.

Shop 'til you drop at Naples's premier shopping hotspot, Vomero! Elevate your style by browsing through trendy boutiques and shops, filled with unique finds. Keep an eye out for artisan crafts, perfect as cherished mementos. Vomero also offers more, including cafes, attractions, key services, and exciting local experiences to round out your visit.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Naples. Enjoy a satisfying meal that will recharge you for tonight's adventures.

As the sun sets, rest up and recharge for the next leg of your road trip in Italy.

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Day 3

Day 3

  • Naples
  • Viterbo
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Drive 321 km, 3 hours 58 min

  • Castel Nuovo
  • Naples National Archaeological Museum
  • Hadrian's Villa
  • More

On day 3 of your road trip in Italy, your travel plans include 2 stops at the most scenic, wondrous, and interesting places in the region. Naples and Tivoli are on today's agenda. In the evening, you’ll end up in Viterbo, where you will stay for 1 night.

When you’re done exploring for the day, you’ll drive to your hotel in Viterbo. Check in and relax before you head out to tour the city.

Viterbo is a place where the culinary landscape is as diverse as its attractions. So before the day ends, treat your palate to a taste of local cuisine at one of the best restaurants in Viterbo.

Relax and recharge in preparation for another adventurous day in Italy!

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Day 4

Day 4

  • Viterbo
  • Florence
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Drive 212 km, 3 hours 9 min

  • Orvieto Cathedral
  • Museo dell'Opera del Duomo
  • Orvieto subterranea
  • Well of St Patrick
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Dive into day 4 of your remarkable road trip in Italy. Today you'll explore 1 destination, including Orvieto. At the end of the day, you’ll unwind at one of the finest accommodations in Florence, where you'll spend 2 nights.

At the end of the day, you will drive to Florence, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Florence, it's often a good idea to reserve a table in advance.

As the day draws to a close, take a moment to unwind and prepare for the next exciting chapter of your road trip in Italy.

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Day 5

Day 5

  • Florence
  • More

Drive 6 km, 49 min

  • Ponte Vecchio
  • piazza della Signoria
  • Uffizi Gallery
  • piazzale Michelangelo
  • Oltrarno
  • More

You’ll stay in Florence for 1 night.

One of the most iconic spots you can visit today is Oltrarno. Allow yourself some time to explore this neighborhood and discover its unique quirks. You'll also find many of the best sightseeing spots nearby.

Don’t forget to check out all the popular tours and experiences you can add to your travel plans in Italy. You can explore and select activities under each day of your itinerary.

Florence is a place where the culinary landscape is as diverse as its attractions. So before the day ends, treat your palate to a taste of local cuisine at one of the best restaurants in Florence.

Get a good night's sleep and look forward to another great day on the road in Italy!

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Day 6

Day 6

  • Florence
  • Siena
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Drive 212 km, 3 hours 30 min

  • Cathedral of Santa Maria del Fiore
  • Galleria dell'Accademia
  • Leaning Tower of Pisa
  • Piazza del Duomo, Pisa
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Experience an unparalleled adventure on day 6 of your road trip in Italy. This exciting part of your journey invites you to discover the renowned landmarks in 2 places, which are Florence and Pisa. At the end of the day, you will retreat to the hotel of your choice in Siena, where will spend 1 night.

After soaking up all the sights on today's itinerary, you'll be ready to head to your accommodation in Siena. Siena offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Siena. Enjoy a relaxing evening as you savor delicious local cuisine.

Relax and look forward to more memorable moments to come!

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Day 7

Day 7

  • Siena
  • Rome
  • More

Drive 241 km, 3 hours 23 min

  • Sistine Chapel
  • St Peter's Basilica
  • Saint Peter's Square
  • Vatican Museums
  • More

Your itinerary for day 7 of your road trip in Italy includes 1 stop and features some of the highlights of Vatican City. At the end of the day, enjoy the comforts of a top-rated hotel in Rome, where you'll spend 3 nights.

When you’re done exploring for the day, you’ll drive to your hotel in Rome. Check in and relax before you head out to tour the city.

After a day of adventure, treat yourself to an exquisite dinner at one of Rome's best restaurants.

Get a good night's sleep and look forward to another great day on the road in Italy!

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Day 8

Day 8

  • Rome
  • More

Drive 3 km, 41 min

  • Altare della Patria
  • Roman Forum
  • Colosseum
  • Trastevere
  • Monti
  • More

A visit to Trastevere is a must on the agenda today. This neighborhood is full of hidden gems and character, perfect for a leisurely stroll. Plus, you’ll be close to some of the city’s most famous sights.

Don’t forget to check out all the popular tours and experiences you can add to your travel plans in Italy. You can explore and select activities under each day of your itinerary.

After a day of adventure, treat yourself to an exquisite dinner at one of Rome's best restaurants.

Relax and recharge in preparation for another adventurous day in Italy!

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Day 9

Day 9

  • Rome
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Drive 12 km, 1 hour 7 min

  • Castel Sant'Angelo
  • Piazza Navona
  • Pantheon
  • piazza del Popolo
  • Via del Corso
  • More

You have 1 night left in Rome. Take the opportunity to experience more of the best attractions and activities in the city.

Don’t forget to check out all the popular tours and experiences you can add to your travel plans in Italy. You can explore and select activities under each day of your itinerary.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Rome. Enjoy a relaxing evening as you savor delicious local cuisine.

Celebrate another amazing day of your road trip adventure in Italy!

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Day 10

Day 10

  • Rome
  • Salerno
  • More

Drive 271 km, 3 hours 25 min

  • Trevi Fountain
  • Piazza di Spagna
  • Spanish Steps
  • Villa Borghese
  • More

On day 10 of your exciting self-drive vacation in Italy, you’ll soak in the magnificence of 1 destination, including Rome. When you’re not sightseeing, take time to relax at your chosen hotel in Salerno, where you’ll be staying for 1 night.

At the end of the day, you will drive to Salerno, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Salerno. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Celebrate another amazing day of your road trip adventure in Italy!

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Day 11

Day 11

  • Salerno
  • Naples
  • More

Drive 170 km, 4 hours 24 min

  • Archaeological Park of Paestum
  • Amalfi Coast
  • Archaeological Park of Pompeii
  • Teatro Grande
  • More

On day 11 of your road trip in Italy, your travel plans include 3 stops at the most scenic, wondrous, and interesting places in the region. Paestum, Amalfi, and Pompei are on today's agenda. In the evening, you’ll end up in Naples, where you will stay for 1 night.

After soaking up all the sights on today's itinerary, you'll be ready to head to your accommodation in Naples. Naples offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

Indulge in a memorable dining experience at one of Naples's most popular restaurants, and connect with friendly locals for a true cultural experience.

Take some time to reflect on your day and savor another beautiful night in Italy.

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Day 12

Day 12

  • Naples - Departure day
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  • Via Toledo
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Day 12 of your road trip in Italy is your departure day. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Italy!

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How it works

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Shortly after booking, you’ll receive your full itinerary, including schedules, locations, and everything you need for a stress-free trip.
Personalize your itinerary
Each package includes a professionally crafted itinerary you can tailor to your travel style. A dedicated travel expert will make sure every detail fits your needs perfectly.
Easily make changes
Need to update plans? No problem. Whether before your trip or mid-journey, we’re just seconds away to help with quick adjustments.
Enjoy seamless planning
With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.
Explore with confidence
From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.
Secure your spot
Confirm your package instantly and lock in the best rate with secure payment and guaranteed availability.
Get instant confirmation
Shortly after booking, you’ll receive your full itinerary, including schedules, locations, and everything you need for a stress-free trip.
Personalize your itinerary
Each package includes a professionally crafted itinerary you can tailor to your travel style. A dedicated travel expert will make sure every detail fits your needs perfectly.
Easily make changes
Need to update plans? No problem. Whether before your trip or mid-journey, we’re just seconds away to help with quick adjustments.
Enjoy seamless planning
With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.
Explore with confidence
From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.

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Your trip is protected, personalized, and priced right. No surprises, no stress.

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