12-Day Italy Self-Drive Road Trip With Itinerary from Perugia to Rome, Siena, Pisa, Venice, and Florence and surrounding area

Experience an unparalleled adventure on day 2 of your road trip in Italy. This exciting part of your journey invites you to discover the renowned landmarks in 2 places, which are Perugia and Pissignano. At the end of the day, you will retreat to the hotel of your choice in Rome, where will spend 4 nights.

Carducci Gardens is must-visit park and a great option for a daytime tour of the area. Continue your journey to Porta Marzia, an increasingly popular monument, located just a leisurely stroll away. Next, head to Rocca Paolina, a symbolic historical landmark, also available for your discovery today.

Continue your road trip and head to your next destination, Pissignano.

One of our top recommendations for your sightseeing is Clitumnus. Spend some time admiring the serene features of the lake before you continue to your next stop.

After soaking up all the sights on today's itinerary, you'll be ready to head to your accommodation in Rome. Rome offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Rome, it's often a good idea to reserve a table in advance.

Have a memorable dining experience in Rome by booking a table at La Pergola, a 3-star Michelin restaurant presenting an exceptional mediterranean and contemporary menu. For a different culinary experience in Rome, Il Pagliaccio shines as one of the top destinations, known for its delicious creative and innovative cuisine. This 2-star Michelin-awardee consistently earns high praises, making it a must-visit addition to your holiday experience. If you're looking for an alternative, Enoteca La Torre is known as a top local spot in Rome for its delicious mediterranean and creative cuisine. This 2-star Michelin awardee is a highly recommended choice for an unforgettable meal.

Following your dinner, dive into the local bar culture at La Botticella Of Poggi Giovanni. Enjoy this evening's relaxed ambiance with delightful drinks. Alternatively, go to Almalu Trastevere, the perfect place for those looking to experience the best of the nightlife. Similarly, Bar Viminale Di Pepi Maurilio provides excellent drinks and a great atmosphere, ensuring a memorable night out.

Head back to your accommodation in Rome and get some rest to prepare for another magical day of your road trip in Italy.

Day 3 of your road trip will take you to the best attractions Rome has to offer. Cherish the 3 nights you have left in the city and use the provided itinerary to discover what to see in Rome.

Whatever your travel style is, Campo De' Fiori is an essential stop in Rome. This top-rated public square provides an insightful glimpse into the city's identity. Next, discover Piazza Navona, an enchanting public square, promising a delightful encounter.

Continue your sightseeing with a visit to Pantheon, an iconic monument. When you’re done, don’t forget to make a stop at the notable Largo Di Torre Argentina. Round off your day at Circus Maximus, another gem in Rome with culturally significant features to discover.

Don’t forget to check out all the popular tours and experiences you can add to your travel plans in Italy. You can explore and select activities under each day of your itinerary.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Rome. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Make sure to reserve a table at RomAntica, an iconic dining spot in Rome. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Coso Ristorante, a popular restaurant in Rome. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of DEROMA - Farine Romane, a hidden gem nestled in Rome. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

After your delicious meal, get a taste of the vibrant nightlife with a visit to Sant' Eustachio Caffè, known for its inviting atmosphere. Yellowsquare Rome is another great option if you’re looking for a place to get the night started. Similarly, Caffè Portofino provides a great setting to enjoy the night away.

Celebrate another amazing day of your road trip adventure in Italy!

On day 4 of your road trip, you will have an entire day to discover what to see in Rome. You’ll stay in Rome for 2 nights.

Visiting Colosseum is always a good idea. This timeless archeological site is a place that is appreciated by travelers and locals alike. Next, immerse yourself in the culturally significant wonders of Roman Forum, a must-see archeological site in the city.

Consider stopping for a small bite to eat or a drink at a local eatery to keep your energy going. When you’re ready, continue your discovery with a visit to Castel Sant'angelo. This extraordinary castle offers an enriching experience. For a change of pace, head to Piazza Del Popolo, where you can take in visually striking features. Conclude your self-guided sightseeing tour with a visit to Villa Borghese These sights offer a fulfilling end to a perfect day.

Don’t forget to check out all the popular tours and experiences you can add to your travel plans in Italy. You can explore and select activities under each day of your itinerary.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Rome, it's often a good idea to reserve a table in advance.

Treat yourself to a wonderful meal at Hotel de Russie, a top-rated dining spot in Rome. If you're in the mood for something new, try La Taverna Italiana, another premier location with a delectable menu. You might also want to book a table at The Parrot Bar. Known for its consistently satisfied patrons, it’s a perfect choice to elevate your evening in Rome.

After savoring a delicious meal, step into the vibrant nightlife at The Apartment Bar Roma, where the evening is just getting started. In the same way, Hotel Hassler Roma offers a unique charm perfect for experiencing the local bar scene in Rome.

Get a good night's sleep and look forward to another great day on the road in Italy!

Day 5 of your road trip across Italy promises a magnificent time exploring what to see in Rome. You have 1 night left in Rome. Take the opportunity to experience more of the best attractions and activities in the city.

Experience Spanish Steps, an extraordinary public square in the city. Then, head to Piazza Di Spagna and soak in the ambiance of this history-steeped public square.

There are many interesting places to see in Rome, and when you are ready for more, go to Trevi Fountain. This is one of the city’s most wondrous history-steeped spots of interest. After exploring the monument, visit the well-known Altare Della Patria. Not far away, you'll also find Basilica Di Santa Maria Maggiore. This church is an UNESCO world heritage-designated highlight in Rome.

Don’t forget to check out all the popular tours and experiences you can add to your travel plans in Italy. You can explore and select activities under each day of your itinerary.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Rome. Enjoy a relaxing evening as you savor delicious local cuisine.

Enjoy a delicious meal at Sofitel Roma Villa Borghese, a highly-rated dining destination in Rome. If you're eager to try something different, consider Centro, another top spot with a tantalizing menu. You might also want to secure a reservation at Ristorante Tema. With a reputation for consistently satisfying customers, it’s an excellent choice to enhance your stay in Rome this evening.

Relax and look forward to more memorable moments to come!

Your itinerary for day 6 of your road trip in Italy includes 1 stop and features some of the highlights of Vatican City. At the end of the day, enjoy the comforts of a top-rated hotel in Siena, where you'll spend 1 night.

When you’re ready to jump back into the car and say goodbye to Rome, you’ll hit the road in the direction of Vatican City, Vatican City. Witness the landscapes transform as you cross the border to Vatican City. This drive usually takes around 11 min.

Savor the day by heading to St. Peter's Basilica, a world-famous major basilica that draws visitors from near and far.

Next, explore Saint Peter's Square, yet another captivating place to see in the area. After the square, make time to go to Vatican Museums.

At the end of the day, you will drive to Siena, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Siena. Enjoy a relaxing evening as you savor delicious local cuisine.

Treat yourself to a delightful dinner at Enoteca I Terzi, highly recommended for tonight's dining. Or, if you're feeling adventurous, why not try Ristorante Tar-Tufo? It's another excellent option with a diverse menu. Consider reserving a table at Antica Trattoria Papei as well. Known for its consistent customer satisfaction, it’s an ideal pick for tonight in Siena.

Continue the enjoyment post-dinner at Meet Life Cafè, a cherished local gathering spot renowned for its welcoming atmosphere. Similarly, Maudit Pub offers a vibrant space for indulging in well-crafted drinks and engaging conversation. You may also want to check out Bar Impero Siena. This bar is a favorite among both locals and visitors looking for a delightful evening out filled with laughter and fun.

Relax and recharge in preparation for another adventurous day in Italy!

Dive into day 7 of your remarkable road trip in Italy. Today you'll explore 2 destinations, including Siena and Lucca. At the end of the day, you’ll unwind at one of the finest accommodations in Pisa, where you'll spend 1 night.

Piazza Del Campo leaves a lasting impression. This public square is one of the most astonishing places to visit in Siena. Next, head to Siena Cathedral, an interesting church, known for its symbolic features.

When you’ve had your share of Siena, prepare for your next destination. Admire the views and listen to some good music as you drive in the direction of Lucca. Your travel time is around 1 hour 45 min.

St Martin Cathedral is an often recommended church we recommend visiting today. Discover its historic features before continuing your self-guided tour to Piazza Napoleone, a romantic public square that’s well-regarded in the area.

Next, stop by Piazza Dell'anfiteatro, an enchanting public square.

When you’re done exploring for the day, you’ll drive to your hotel in Pisa. Check in and relax before you head out to tour the city.

Pisa is a place where the culinary landscape is as diverse as its attractions. So before the day ends, treat your palate to a taste of local cuisine at one of the best restaurants in Pisa.

Dine in style at Anima di Grano Pizzeria Napoletana Pisa Italy, a top recommendation for dinner tonight. Or, for a change of pace, il Mercante boasts a menu that's sure to impress. Also, be sure to check out La Ghiotteria. Known as a local hotspot, it’s a great choice for tonight in Pisa.

Keep the excitement of the evening going by visiting a bar or two. Jeffer Cocktails & Friends is an excellent place to start. You could also check out Le Parisien Wine Bar, offering a different kind of charm. A last recommendation for the day is Las Volta Cocktailbar. This bar promises an enjoyable experience with tasty drinks and a vibrant setting.

Raise your glass and celebrate another amazing day of your road trip in Italy!

On day 8 of your exciting self-drive vacation in Italy, you’ll soak in the magnificence of 2 destinations, including Pisa and Bologna. When you’re not sightseeing, take time to relax at your chosen hotel in Venice, where you’ll be staying for 1 night.

Your adventure in Pisa is only getting started when you visit Leaning Tower Of Pisa, a world-famous local hot spot. Another notable attraction to explore is Piazza Del Duomo, Pisa. This iconic public square is known for its UNESCO world heritage-listed appeal.

After soaking in the highlights of these sights, take some time to wander Pisa's streets and immerse yourself in the local atmosphere. When you're ready to continue your sightseeing adventure, head to Pisa Cathedral. This UNESCO world heritage-listed church offers a fascinating experience that many visitors find memorable.

After soaking in Pisa’s unique atmosphere, jump into the car with a full heart and drive in the direction of your next destination: Bologna. Expect your car journey to take a minimum of 1 hour 57 min. When you arrive in Bologna, it's time to take a break from the road.

Savor the day by heading to Faizan-e-madina Bologna, an often recommended mosque that draws visitors from near and far.

After soaking up all the sights on today's itinerary, you'll be ready to head to your accommodation in Venice. Venice offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Venice. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Prepare for an extraordinary culinary adventure in Venice by booking a table at Local, a 1-star Michelin restaurant that boasts an exceptional contemporary menu. For a different flavor experience, head to Wistèria, renowned for its delectable contemporary and venetian dishes. This 1-star Michelin restaurant consistently wows guests, making it a memorable stop during your holiday. Looking for another option? Visit Quadri, a local gem known for its delightful modern cuisine in Venice. Nestled in the city's heart, this 1-star Michelin restaurant is a perfect choice for discerning restaurant-goers seeking a new experience.

Explore the vibrant nightlife at Al Parlamento after your meal, a hub for lively evenings and memorable moments. Or, head to The Caffe Rosso for a great selection of flavorful drinks and a charming setting. Furthermore, Adagio is perfect for those looking to extend their night with a touch of local flavor.

Relax and look forward to more memorable moments to come!

On day 9 of your road trip in Italy, your travel plans include 2 stops at the most scenic, wondrous, and interesting places in the region. Venice and Padua are on today's agenda. In the evening, you’ll end up in Florence, where you will stay for 2 nights.

Awaiting your discovery is the wondrous Rialto Bridge, a history-steeped historical landmark in Venice. Next, go to St Mark's Campanile.

After visiting Rialto Bridge and St Mark's Campanile, have a stroll along Venice's streets and take in the local charm. Continue your sightseeing by heading to Piazza San Marco. This UNESCO world heritage-designated public square offers a unique experience.

Fasten your seatbelt and make your way to your next stop — Padua, home to many well-known sights in the region. Keep in mind that your travel time from Venice to Padua may take around 39 min without traffic disruptions. Upon arrival in Padua, we highly recommend checking out some of the top attractions.

Spend your afternoon discovering The Basilica Of St. Anthony, a notable church known for its culturally significant features. Next, continue your sightseeing at Prato Della Valle, a popular public square.

At the end of the day, you will drive to Florence, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

After a day of adventure, treat yourself to an exquisite dinner at one of Florence's best restaurants.

Treat yourself to an extraordinary dining experience at Enoteca Pinchiorri, a 3-star Michelin restaurant offering an incredible italian contemporary menu. Alternatively, if your taste buds call for something different, Santa Elisabetta is one of the best restaurants for creative and mediterranean cuisine in Florence. This 2-star Michelin-awardee earns consistently high praises from guests. We also recommend checking out the menu at Gucci Osteria da Massimo Bottura. As a top-rated establishment with 1 Michelin star, it is an ideal choice for italian contemporary and international cuisine in the city.

To truly maximize your evening out, consider visiting Manifattura after dinner. This bar is known for offering some of the best drinks and vibes in the city. Alternatively, head to Se·sto On Arno Rooftop Bar, another bar with an inviting ambiance. Similarly, Il Vinile also offers a great atmosphere, ensuring a night filled with enjoyment and relaxation.

Get a good night's sleep and look forward to another great day on the road in Italy!

Day 10 offers an itinerary packed with the best things to see in Perugia. You’ll stay in Florence for 1 night more, offering you enough time to explore at a relaxed pace.

Piazzale Michelangelo makes a great addition to your morning plans. This top-rated observation deck is a majestic place to see in Florence. Continue your discovery at Basilica Of Santa Croce In Florence, an inviting church with stories to tell.

As you stroll around Florence, take in the distinct atmosphere and learn what makes this city so unique. Maximize your sightseeing with a visit to Piazza Della Signoria. This impressive public square offers a remarkable encounter with Florence. Next, make your way to Uffizi Gallery to add another highlight to your day. After that, visit Ponte Vecchio, a world-famous historical landmark that’s sure to impress. Whether you decide to get entrance tickets for all attractions or you prefer admiring from a distance, amazing experiences await on this day in Florence.

Don’t forget to check out all the popular tours and experiences you can add to your travel plans in Italy. You can explore and select activities under each day of your itinerary.

After a day of adventure, treat yourself to an exquisite dinner at one of Florence's best restaurants.

Savor the flavors at Ditta Artigianale, a top pick for dinner tonight. Alternatively, Trattoria Da Burde beckons with its unique menu offerings. Also, consider Casa Toscana. With its consistent customer satisfaction, it’s an excellent option for dining in Florence tonight.

Cap off your culinary experience with a visit to some of the most celebrated bars in the area. For instance, Bar 50 Rosso stands out as an excellent choice for a post-dinner cocktail. Alternatively, Bitter Bar offers an ideal atmosphere to enjoy the pleasures of the night. Archea Brewery is also a great option that provides a perfect setting for a relaxing evening.

Say good night to Florence and look forward to another great day of your road trip in Italy!

Experience an unparalleled adventure on day 11 of your road trip in Italy. This exciting part of your journey invites you to discover the renowned landmarks in 1 place, which are Florence. At the end of the day, you will retreat to the hotel of your choice in Perugia, where will spend 1 night.

Cathedral Of Santa Maria Del Fiore makes a great addition to your morning plans. This spectacular church is an inviting place to see in Florence. Continue your discovery at Basilica Di Santa Maria Novella, Firenze (fi), an enchanting church with stories to tell.

As you stroll around Florence, take in the distinct atmosphere and learn what makes this city so unique. Maximize your sightseeing with a visit to Central Market. This captivating food market offers an instagrammable encounter with Florence. Next, make your way to Galleria Dell'accademia to add another highlight to your day. Whether you decide to get entrance tickets for all attractions or you prefer admiring from a distance, amazing experiences await on this day in Florence.

When you’re done exploring for the day, you’ll drive to your hotel in Perugia. Check in and relax before you head out to tour the city.

Indulge in a memorable dining experience at one of Perugia's most popular restaurants, and connect with friendly locals for a true cultural experience.

Treat yourself to a delicious dinner at La Taverna, an excellent option for tonight's dining. Looking for something different? Ristorante del Sole offers a tantalizing alternative with its diverse menu. And don’t miss Al Mangiar Bene. Known for great service, it’s a fantastic choice for tonight in Perugia.

Unwind after your meal by stepping into Caffè Fortebraccio. This venue is celebrated for its extensive drink selections and cozy vibes. Alternatively, Caffe Del Banco offers a dynamic and energetic atmosphere for a glass or two. Don’t overlook Dempsey's Perugia, another top-rated bar in the area.

Savor another day of unforgettable experiences in Italy!