12-Day Italy Road Trip from Pisa to Perugia, Rome, Naples, Viterbo, and Florence

Say hello to Pisa! Your exciting road trip through Italy is just about to start. Navigating the top places to see in the region is a breeze with a car. The rental vehicle of your choice will be ready for pickup upon your arrival in the city. You will stay in Pisa for 1 night before you continue your adventure!

Pisa is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out Knights' Square or taking a stroll in the city center. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

As afternoon approaches, head to your chosen hotel in Pisa. Check-in typically starts around 2 to 4 PM at hotels in Italy. We recommend staying at a hotel in a central location for easy access to the best attractions, restaurants, and bars in the city.

As dinnertime approaches, it's time to head out for a bite to eat in Pisa. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.

Don’t miss out on dining at Ristorante Capodimonte Pisa, a top-rated dining destination in Pisa. If you're in the mood to try something new, consider Baribaldi Pisa, another top spot with a mouthwatering menu. You might also want to secure a reservation at Restaurant -Pizzeria Il Mio Capriccio. With a reputation for consistently satisfied customers, it’s a perfect choice to enhance your stay in Pisa this evening.

After your delicious meal, get a taste of the vibrant nightlife with a visit to JEFFER cocktails & friends, known for its inviting atmosphere. Le Parisien Wine Bar is another great option if you’re looking for a place to get the night started. Similarly, Las Volta cocktailbar provides a great setting to enjoy the night away.

Raise a toast to the start of your 12-day road trip in Italy!

On day 2 of your road trip in Italy, you will get a true taste of the freedom a self-drive vacation in Europe entails. Today’s travel plans include stops at the most scenic, wondrous, and interesting places in Pisa and Cascine Vecchie. In the evening, you’ll end up in Perugia, where you will stay for 1 night.

Start your sightseeing with a visit to Leaning Tower of Pisa. This bell tower is a popular stop on travelers’ itineraries in Pisa, with an average rating of 4.7 out of 5 stars by 116,882 visitors. Around 3,200,000 people visit this attraction every year.

Pisa Cathedral is another popular place of interest you can visit today. The average rating of 4.8 out of 5 stars from 8,361 reviews gives you an idea of other visitors’ experience at this attraction.

If it’s still bright and early, make your way to Piazza del Duomo, Pisa. Visitors have rated this square an average of 4.7 out of 5 stars in 104,550 reviews.

Campo santo is another unique site you can experience today. This attraction is a cemetery rated an average of 4.6 out of 5 stars in 586 reviews.

When you arrive in Cascine Vecchie, it's time to take a break from the road.

When you're ready to see some sights, Parco Regionale Migliarino, San Rossore, Massaciuccoli is a great place to start. This park is rated an average of 4.4 out of 5 stars by 9,632 visitors.

When you’re done exploring for the day, you’ll drive to Perugia, where you'll have a hotel waiting for you. Check in and spend some time relaxing before you head out to explore the city.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Perugia.

Make sure to reserve a table at Ristorante Settimo Sigillo, an iconic dining spot in Perugia. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Bar Pellas, a popular restaurant in Perugia. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of La Taverna, a hidden gem nestled in Perugia. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

Continue the enjoyment post-dinner at Tommi Bar, a cherished local gathering spot renowned for its welcoming atmosphere. Similarly, Valentina offers a vibrant space for indulging in well-crafted drinks and engaging conversation. You may also want to check out Caffe Dal Perugino. This bar is a favorite among both locals and visitors looking for a delightful evening out filled with laughter and fun.

Relax and reminisce about your day in Italy and look forward to more memorable moments to come!

Experience an unparalleled adventure on day 3 of your road trip in Italy. This exciting part of your journey invites you to discover the renowned landmarks in 1 vibrant destinations - Vatican City. After a day filled with exploration and new experiences, you will retreat to the hotel of your choice in Rome. You will spend 3 nights here for some well-deserved relaxation.

When you arrive in Vatican City, it's time to take a break from the road.

Your sightseeing of the day begins at Vatican Museums, a remarkable art museum where it’s easy to get lost in exploration. This top attraction is rated an average of 4.6 out of 5 stars in 133,310 reviews. Each year, this popular place of interest welcomes approximately 1,612,530 visitors.

Next, satisfy your wanderlust at Saint Peter's Square. This square has an average rating of 4.8 out of 5 stars from 38,954 travelers.

Sistine Chapel is another must-visit attraction. This renowned chapel offers a memorable experience, well worth a stop on your self-guided sightseeing tour. Rated 4.7 out of 5 stars by 52,083 travelers, it's one of the more popular places to see in the area.

Beyond the above-mentioned sites, you also have the opportunity to visit St. Peter's Basilica. This well-loved major basilica boasts a 4.8 out of 5-star rating from 131,043 reviews. In a single year, approximately 11,000,000 visitors add this sightseeing spot to their travel itineraries.

At the end of the day, you will drive to Rome, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

As you explore more of Rome, you'll discover that its culinary landscape is as diverse as its attractions. Whether you're craving traditional dishes bursting with local flavors or innovative creations that push the boundaries of taste, you're sure to find a dining experience that satisfies your cravings.

Prepare for an extraordinary culinary adventure in Rome by booking a table at La Pergola, a 3-star Michelin restaurant that boasts an exceptional mediterranean and contemporary menu. For a different flavor experience, head to Il Pagliaccio, renowned for its delectable creative and innovative dishes. This 2-star Michelin restaurant consistently wows guests, making it a memorable stop during your holiday. Looking for another option? Visit Enoteca La Torre, a local gem known for its delightful mediterranean and creative cuisine in Rome. Nestled in the city's heart, this 2-star Michelin restaurant is a perfect choice for discerning restaurant-goers seeking a new experience.

Explore the vibrant nightlife at La Botticella of Poggi Giovanni after your meal, a hub for lively evenings and memorable moments. Or, head to Sant' Eustachio Caffè for a great selection of flavorful drinks and a charming setting. Furthermore, Caffè Portofino is perfect for those looking to extend their night with a touch of local flavor.

Raise your glass and celebrate another amazing day of your road trip in Italy!

Day 4 of your road trip will take you to the best attractions Rome has to offer. Cherish the 2 nights you have left in Rome by discovering the best things there are to see and do in the city.

Begin your sightseeing with a visit to Trevi Fountain. This sculpture is rated an average of 4.8 out of 5 stars in 343,494 reviews.

Next up, make your way to Altare della Patria. This architectural structure has an average rating of 4.8 out of 5 stars from 49,843 reviews. Usually, around 1,683,070 people visit Altare della Patria every year.

When you’re ready for your next sight of the day, continue to Roman Forum. This square has an average rating of 4.7 out of 5 stars from 114,450 visitors.

Beyond the above-mentioned attractions, you also have the opportunity to visit Colosseum. This roman amphitheatre is rated an average of 4.7 out of 5 stars by 328,821 visitors. Visiting Colosseum means you'll be one of 7,400,000 people who do so every year.

If you’re keen to explore even more, then consider a visit to Circus Maximus. This circus is a much-appreciated attraction with an average rating of 4.4 out of 5 stars from 44,741 visitors.

You can learn more about Rome today by going on a tour. Rome offers many top-rated tours and unique experiences that will inspire you. You can browse and select your favorites below.

As you explore more of Rome, you'll discover that its culinary landscape is as diverse as its attractions. Whether you're craving traditional dishes bursting with local flavors or innovative creations that push the boundaries of taste, you're sure to find a dining experience that satisfies your cravings.

Enjoy a delicious meal at DEROMA - Farine Romane, a top-rated dining destination in Rome. If you're in the mood to try something new, consider La Taverna Italiana, another top spot with a mouthwatering menu. You might also want to secure a reservation at Centro. With a reputation for consistently satisfied customers, it’s a perfect choice to enhance your stay in Rome this evening.

Continue your evening by exploring the vibrant nightlife scene at The Apartment Bar Roma, a prime destination for a thrilling night out. Also, don’t forget to check out Hotel Hassler Roma, a bar that offers unique local touches.

Relax and reminisce about your day in Italy and look forward to more memorable moments to come!

Day 5 offers a multitude of experiences. You will stay in Rome for 1 night more, offering you enough time to explore at a relaxed pace.

Journey into the unknown at Villa Borghese, a unique attraction awaiting your visit. This remarkable urban zone of rome has an average rating of 4.6 out of 5 stars from 69,749 reviews.

When you’re ready to continue your sightseeing, piazza del Popolo is a recommended place to visit. This square is rated an average of 4.6 out of 5 stars in 89,807 reviews.

Another must-see attraction in Rome is Spanish Steps. Rated an average of 4.5 out of 5 stars by 57,211 travelers, this popular tourist destination in Rome offers an experience you will remember.

Piazza di Spagna is another popular stop on travelers' itineraries in Rome. This square promises memorable moments of exploring. Other travelers have rated this attraction 4.7 out of 5 stars in 113,658 reviews.

Lastly, don't miss out on Basilica di Santa Maria Maggiore. Rated 4.8 out of 5 stars by 27,678 local and international travelers, it's a popular place to visit.

There are plenty of experiences you can choose from in Italy that will add excitement to your vacation. When you’re keen to discover what else Rome has in store for you, use this day to go on a tour. This tour allows curious travelers like you to experience the best of the country. You can make the most of your time in Italy by scrolling down and selecting tours and activities to include on your itinerary for the day.

Indulge in a memorable dining experience at one of Rome's most popular restaurants, and connect with friendly locals for an authentic adventure.

Savor the flavors at Ristorante Tema, a top pick for dinner tonight. Alternatively, Maccheroni beckons with its unique menu offerings. Also, consider RoYaL Art Cafè Roma. With its consistent customer satisfaction, it’s an excellent option for dining in Rome tonight.

Head back to your accommodation in Rome and get some rest in preparation for another magical day of your road trip in Italy!

On day 6 of your exciting self-drive vacation in Italy, you’ll soak in the magnificence of 1 destination, Rome. When you’re not sightseeing, take time to relax at your selected hotel in Naples, where you’ll be staying for 2 nights.

Begin your sightseeing with a visit to largo di Torre Argentina. This square is rated an average of 4.5 out of 5 stars in 30,433 reviews.

Next up, make your way to Pantheon. This roman temple has an average rating of 4.8 out of 5 stars from 189,682 reviews. Usually, around 30,000,000 people visit Pantheon every year.

When you’re ready for your next sight of the day, continue to Piazza Navona. This square has an average rating of 4.7 out of 5 stars from 158,771 visitors.

Beyond the above-mentioned attractions, you also have the opportunity to visit Campo de' Fiori. This square is rated an average of 4.4 out of 5 stars by 51,133 visitors.

If you’re keen to explore even more, then consider a visit to Castel Sant'Angelo. This museum is a much-appreciated attraction with an average rating of 4.7 out of 5 stars from 72,431 visitors. Approximately 918,591 travelers visit Castel Sant'Angelo every year.

After soaking up all the sights of today's itinerary, you'll be ready to hit the road in the direction of Naples. Naples offers plenty of top-rated hotels and other places to stay on any travel budget. Check in at the hotel of your choice and take some time to relax before you head out to explore.

As dinnertime approaches, it's time to head out for a bite to eat in Naples. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.

Get ready for an unforgettable culinary journey in Naples by reserving a table at Veritas. Renowned as a 1-star Michelin restaurant, it offers an exceptional campanian and contemporary menu. For a different taste experience, head to Il Comandante, recognized for its delicious creative and mediterranean dishes. This 1-star Michelin restaurant consistently impresses guests, ensuring a memorable addition to your holiday. Looking for another option? Make sure to visit ARIA, a local favorite known for its delightful contemporary and modern cuisine in Naples. Nestled in the heart of the city, this restaurant with 1 Michelin star is an ideal choice for discerning contemporary and modern foodies seeking culinary excellence.

Continue your lively evening at Happening cocktail bar, a perfect place for winding down or revving up the night, depending on which mood you’re in. Shanti Art Musik Bar is another excellent bar that offers a great selection of drinks to suit any mood. If you prefer to go somewhere else, Gran Caffè Gambrinus ensures a night out tailored to your taste.

Take some time to reflect on your day and savor another beautiful night in Italy.

Greet day 7 of your road trip in Italy with a smile and start your day with a hearty breakfast. You will return to Naples for your remaining 1 night in the city later today, but first, it’s time for some exploring! On the agenda for this day, you’ll find only the best things to see and do in Amalfi and Naples.

Begin your sightseeing with a visit to Castel Nuovo. This extraordinary castle is rated an average of 4.4 out of 5 stars by 28,032 visitors.

Next, make your way to Cappella Sansevero. This top attraction is a former church with an average rating of 4.7 out of 5 stars by 25,405 visitors. Cappella Sansevero welcomes 175,138 yearly visitors.

We also recommend a visit to Napoli Sotterranea Percorso Ufficiale. This museum is rated 4.6 out of 5 stars by 19,274 travelers.

Fasten your seatbelt and make your way to your next stop. Amalfi, home to many well-known sights in the region, is a lovely destination on today’s itinerary. Keep in mind that your travel time from Naples to Amalfi may take around 1 hour 26 min without traffic disruptions. Upon arrival in Amalfi, we highly recommend checking out some of the top attractions.

Kick off the day at Amalfi Coast, a top pick for today’s sightseeing. This coast is rated an average of 4.7 out of 5 stars in 70,989 reviews.

When you’re done exploring the area’s best attractions, you’ll drive back to your accommodation in Naples.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Naples.

Make sure to book a table at La Lazzara Trattoria e Pizzeria, a popular restaurant in Naples. This acclaimed restaurant and its mouthwatering dishes have earned the admiration of countless food lovers. Alternatively, experience a taste of Naples at Trattoria Castel Nuovo, a popular local restaurant. With a menu designed to impress, it promises a journey of flavors that will leave you captivated. Another top-rated restaurant to try is Ristorante Amici Miei. As a dining spot that gains consistently high praise from guests, it’s an ideal choice to enhance your time to Naples tonight.

After enjoying a fulfilling meal, continue your evening at Archivio Storico - Cocktail Bar & Wonderfood, ideal for those looking to unwind with a drink in a comfortable setting. Alternatively, Babette Pub offers a welcoming atmosphere for easing into the nightlife. Similarly, Gran Caffè Cimmino provides an excellent environment for a relaxed and enjoyable evening.

Say good night to Naples and look forward to another great day of your road trip in Italy!

Embark on another extraordinary experience on day 8 of your road trip in Italy. Today, you will make 2 stops and experience some of the highlights of Naples and Tivoli. At the end of the day, you will enjoy the comforts of a top-rated hotel in Viterbo, which will be your home away from home for 1 night.

Make piazza del Plebiscito your first stop of the day. Previous visitors have rated this square an average of 4.7 out of 5 stars in 58,141 reviews.

Next up, make a stop at Ovo Castle. With an average rating of 4.6 out of 5 stars by 33,595 visitors, it's easy to understand why so many people visit this point of interest every year.

Naples National Archaeological Museum is another attraction you can visit on this day of your vacation. This archaeological museum has an average rating of 4.6 out of 5 stars by 27,352 visitors. Up to 616,878 travelers come to Naples every year to see Naples National Archaeological Museum with their own eyes.

Embrace the thrill of the open road as you wave goodbye to Naples and set your GPS to Tivoli. While on the road, immerse yourself in your favorite road trip tunes or sample the sounds from a local radio station. This car ride usually takes around 2 hours 12 min. Upon reaching Tivoli, unwind, observe, and explore. The best things to do, see, and eat are waiting for you.

Journey into the unknown at Hadrian's Villa, a unique attraction awaiting your visit. This remarkable archaeological site has an average rating of 4.6 out of 5 stars from 9,813 reviews. Every year, Hadrian's Villa welcomes more than 77,557 curious visitors.

When you’re done exploring for the day, you’ll drive to Viterbo, where you'll have a hotel waiting for you. Check in and spend some time relaxing before you head out to explore the city.

Indulge in a memorable dining experience at one of Viterbo's most popular restaurants, and connect with friendly locals for an authentic adventure.

As a top-rated it is an ideal choice in the city.

Celebrate another amazing day of your road trip adventure in Italy!

Dive into day 9 of your remarkable road trip in Italy. Today you will explore Orvieto, where you will have the opportunity to experience all the top things to see and do. At the end of the day, you’ll unwind at one of the finest accommodations in Florence. You’ll stay here for 2 nights.

Once you're ready to continue your road trip, it's time to buckle up and drive, eagerly anticipating your arrival in Orvieto. This drive usually takes around 53 min, without any stops or traffic disruptions.

Kick off the day at Orvieto Cathedral, a top pick for today’s sightseeing. This catholic cathedral is rated an average of 4.8 out of 5 stars in 15,057 reviews.

Today is also your chance to visit Orvieto Underground. Orvieto Underground is an archaeological site with an average rating of 4.6 out of 5 stars from 1,517 reviews. Attracting more than 37,000 yearly visitors, this place of interest is an attraction you don’t want to miss out on.

Fasten your seatbelt and make your way to your next stop. Orvieto, home to many well-known sights in the region, is a lovely destination on today’s itinerary. Keep in mind that your travel time from Viterbo to Orvieto may take around 53 min without traffic disruptions. Upon arrival in Orvieto, we highly recommend checking out some of the top attractions.

Seize the day by visiting some of the best attractions in the area, like Well of St. Patrick. This extraordinary point of interest has an average rating of 4.5 out of 5 stars from 14,274 visitors.

At the end of the day, you will drive to Florence, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

After a day of adventure, treat yourself to an exquisite dinner at one of Florence's best restaurants.

Start your culinary exploration in Florence by securing a reservation at Enoteca Pinchiorri. This renowned restaurant holds , and offers an exceptional menu of italian contemporary cuisine. For another dining delight, visit Santa Elisabetta, celebrated for its delectable creative and mediterranean menu. This acclaimed 2-star Michelin-recipient consistently leaves guests satisfied, making it a must-visit during your holiday. Looking for a different experience? Discover Gucci Osteria da Massimo Bottura, a top local spot known for its tantalizing italian contemporary and international menu. With a 1-star Michelin recognition, it guarantees an exceptional dining adventure.

After your delicious meal, get a taste of the vibrant nightlife with a visit to Manifattura, known for its inviting atmosphere. SE·STO on Arno Rooftop Bar is another great option if you’re looking for a place to get the night started. Similarly, Archea Brewery provides a great setting to enjoy the night away.

As the sun sets on another day of adventure, rest up and recharge for the next leg of your road trip in Italy.

Day 10 of your road trip across Italy promises a magnificent time exploring Florence. You have 1 night left in Florence. Take the opportunity to experience more of the best attractions and activities in the city.

Start your sightseeing with a visit to piazzale Michelangelo. This square is a popular stop on travelers’ itineraries in Florence, with an average rating of 4.8 out of 5 stars by 77,744 visitors.

Basilica of Santa Croce in Florence is another popular place of interest you can visit today. The average rating of 4.7 out of 5 stars from 28,544 reviews gives you an idea of other visitors’ experience at this attraction.

If it’s still bright and early, make your way to piazza della Signoria. Visitors have rated this square an average of 4.8 out of 5 stars in 66,956 reviews.

Uffizi Gallery, boasting an annual visitor count of up to 2,011,219 people, is another unique site you can experience today. This attraction is a national museum rated an average of 4.7 out of 5 stars in 61,794 reviews.

Make your way to the fantastic Ponte Vecchio, perhaps the most famous deck arch bridge in Florence. This attraction is rated 4.7 out of 5 stars by 118,099 travelers.

Immerse yourself in the local scene through top-rated tours and activities. You can choose from a wide variety of easy to challenging tours and easily add them to your travel package below.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Florence. Enjoy a relaxing evening as you savor delicious local cuisine and reflect on the day's adventures.

Don’t miss out on dining at Trattoria Da Burde, a top-rated dining destination in Florence. If you're in the mood to try something new, consider Ristorante Buca Mario, another top spot with a mouthwatering menu. You might also want to secure a reservation at Eataly Firenze. With a reputation for consistently satisfied customers, it’s a perfect choice to enhance your stay in Florence this evening.

Raise your glass and celebrate another amazing day of your road trip in Italy!

On day 11 of your road trip in Italy, you will get a true taste of the freedom a self-drive vacation in Europe entails. Today’s travel plans include stops at the most scenic, wondrous, and interesting places in Florence and Siena. In the evening, you’ll end up in Pisa, where you will stay for 1 night.

Be one of the day’s first visitors at Cathedral of Santa Maria del Fiore. This church is rated an average of 4.8 out of 5 stars by 76,359 visitors.

When you’re finished at Cathedral of Santa Maria del Fiore, head to Galleria dell'Accademia. This one-of-a-kind national museum is rated an average of 4.6 out of 5 stars in 34,429 reviews. Every year, approximately 1,719,645 travelers come here to experience the national museum for themselves.

Beyond the above-mentioned attractions, you also have the opportunity to visit Central Market. This point of interest is rated an average of 4.4 out of 5 stars by 43,100 visitors.

Set your GPS to Siena and hit the road. Expect a journey of approximately 1 hour 19 min without stops. Soak in the beautiful landscapes as you drive and look forward to exploring your next destination. Siena beckons with new experiences!

Begin your sightseeing with a visit to piazza del Campo. This extraordinary square is rated an average of 4.8 out of 5 stars by 64,175 visitors.

After soaking up all the sights of today's itinerary, you'll be ready to hit the road in the direction of Pisa. Pisa offers plenty of top-rated hotels and other places to stay on any travel budget. Check in at the hotel of your choice and take some time to relax before you head out to explore.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Pisa. Enjoy a relaxing evening as you savor delicious local cuisine and reflect on the day's adventures.

Dine in style at Ristorante alle Bandierine, a top recommendation for dinner tonight. Or, for a change of pace, Barrique Cocktail And Bistrot boasts a menu that's sure to impress. Also, be sure to check out Filter Coffee Lab. Known as a local hotspot, it’s a great choice for tonight in Pisa.

Cap off your dinner by heading to Bar Mocambo, ideal for a leisurely evening with a drink in hand. Tree is another bar that offers an enjoyable setting. Similarly, Chupiteria is also a popular place to go on a night out, perfect for relaxing and socializing.

As the day draws to a close, take a moment to unwind and prepare for the next exciting chapter of your road trip in in Italy.

Day 12 of your road trip in Italy is your departure day. This is your chance to catch a last glimpse of Pisa before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

Make the most of your final day in Italy by visiting Pisa’s iconic markets and shopping establishments. Your stay’s proximity to the city’s retail haven invites an unhurried and unforgettable exploration of its variety of stores and establishments. Secure the perfect souvenirs for your family and friends back home or buy yourself a remembrance of your amazing experience in Italy. Take home a piece of Italy with these souvenirs, keeping your adventures close.

Make Palazzo Gambacorti one of your first sightseeing stops in Pisa. Rated an average of 4.3 out of 5 stars by 309 travelers, a visit to this local attraction makes for a great introduction to the area.

Before you conclude your road trip in Italy, drop by another restaurant for a last chance at a memorable dining experience in Pisa.

If you're eager to try something different, consider Kiste' - La Pizza Artigianale. It's the second restaurant coming from the tower. , another top spot with a tantalizing menu.

You’ll then say farewell to Pisa. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Italy!