12-Day Italy Self-Drive Road Trip With Itinerary from Pisa traveling east to Perugia, Rome, Naples, Viterbo, and Florence

Experience an unparalleled adventure on day 2 of your road trip in Italy. This exciting part of your journey invites you to discover the renowned landmarks in 2 vibrant destinations - Pisa and Cascine Vecchie. After a day filled with exploration and new experiences, you will retreat to the hotel of your choice in Perugia. You will spend 1 night here for some well-deserved relaxation.

Pisa is brimming with adventures. Today’s wonderful stops include a monument, a church, a public square, a cemetery and much more! Begin your sightseeing adventure at the globally renowned Leaning Tower Of Pisa. Just a short distance away is Pisa Cathedral, a breathtaking church that draws visitors from far and near.

Continue your journey to Piazza Del Duomo, Pisa, one of the city’s most wondrous spots that you shouldn’t miss. Another great site to visit is the curiosity-inducing Campo Santo.

As you’ve unraveled the marvels of Pisa, it’s time to gear up for the next part of your road trip adventure. Under favorable conditions, your drive to Cascine Vecchie may take around 9 min. Upon your arrival in Cascine Vecchie, you’ll be greeted with the opportunity to do some sightseeing and exploring.

Your self-guided tour starts at Parco Regionale Migliarino, San Rossore, Massaciuccoli, an up-and-coming nature reserve that is sure to impress. Take in the surroundings and enjoy the freedom of exploring before you continue your journey.

After soaking up all the sights of today's itinerary, you'll be ready to hit the road in the direction of your accommodation in Perugia. Perugia offers plenty of top-rated hotels and other places to stay on any travel budget. Take some time to relax before you head out to explore.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Perugia. Enjoy a relaxing evening as you savor delicious local cuisine and reflect on the day's adventures.

Make sure to reserve a table at Ristorante Settimo Sigillo, an iconic dining spot in Perugia. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Caffè Baglioni, a popular restaurant in Perugia. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of Bar Pellas, a hidden gem nestled in Perugia. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

Let the evening flow smoothly from dinner to drinks at Tommi Bar, a top-rated bar in the area. For other recommendations, Valentina provides a perfect setting for rounding out your night with style and great drinks. Likewise, Caffe Dal Perugino offers a memorable night with diverse drink options and excellent service.

Head back to your accommodation in Perugia and get some rest in preparation for another magical day of your road trip in Italy!

On day 3 of your road trip in Italy, you will get a true taste of the freedom a self-drive vacation in Europe entails. Today’s travel plans include stops at the most scenic, wondrous, and interesting places in Vatican City. In the evening, you’ll end up in Rome, where you will stay for 3 nights.

Fasten your seatbelt and make your way to your next stop. Vatican City, home to many well-known sights in the region, is a lovely destination on today’s itinerary. Keep in mind that your travel time from Perugia to Vatican City may take around 2 hours 17 min without traffic disruptions. Upon arrival in Vatican City, we highly recommend checking out some of the top attractions.

Next, visit Sistine Chapel, a spectacular chapel that offers a unique experience. Be sure to also explore St. Peter's Basilica, a nearby major basilica, which is highly recommended by other travelers.

When you’re done exploring for the day, you’ll drive to your hotel in Rome. Check in and spend some time relaxing before you head out to tour the city.

After a day of adventure, treat yourself to an exquisite dinner at one of Rome's best restaurants.

Experience a taste of local culinary excellence while in Rome by securing a table at La Pergola. An esteemed 3-star Michelin restaurant, it features an exceptional mediterranean and contemporary menu. For an alternative taste experience, visit Il Pagliaccio, famous for its scrumptious creative and innovative dishes. This 2-star Michelin venue consistently impresses guests, making it a standout addition to your holiday plans. Looking for another choice? Discover Enoteca La Torre, a local favorite celebrated for its exquisite mediterranean and creative cuisine in Rome. Located in the heart of the city, this 2-star Michelin restaurant is an ideal pick for mediterranean and creative cuisine lovers seeking top-notch culinary experiences.

Continue your lively evening at La Botticella Of Poggi Giovanni, a perfect place for winding down or revving up the night, depending on which mood you’re in. Almalu Trastevere is another excellent bar that offers a great selection of drinks to suit any mood. If you prefer to go somewhere else, Bar Viminale Di Pepi Maurilio ensures a night out tailored to your taste.

As the sun sets on another day of adventure, rest up and recharge for the next leg of your road trip in Italy.

Day 4 offers a multitude of experiences. You will stay in Rome for 2 nights more, offering you enough time to explore at a relaxed pace.

Set out on a day brimming with fun adventures, romantic experiences, and breathtaking views. Start at the timeless Trevi Fountain, a visually striking monument in Rome. Next, go to Altare Della Patria.

After visiting Trevi Fountain and Altare Della Patria, take time to explore Rome's streets and absorb its charm. Continue your sightseeing by heading to Roman Forum. This breathtaking archeological site offers a unique experience. Colosseum is another noteworthy stop. End your self-guided sightseeing tour on top with a visit to Circus Maximus, one of the most instagrammable places to visit in Rome.

Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.

Indulge in a memorable dining experience at one of Rome's most popular restaurants, and connect with friendly locals for an authentic adventure.

Savor the flavors at RomAntica, a top pick for dinner tonight. Alternatively, Coso Ristorante beckons with its unique menu offerings. Also, consider DEROMA - Farine Romane. With its consistent customer satisfaction, it’s an excellent option for dining in Rome tonight.

To truly maximize your evening out, consider visiting Sant' Eustachio Caffè after dinner. This bar is known for offering some of the best drinks and vibes in the city. Alternatively, head to Yellowsquare Rome, another bar with an inviting ambiance. Similarly, Caffè Portofino also offers a great atmosphere, ensuring a night filled with enjoyment and relaxation.

As the day draws to a close, take a moment to unwind and prepare for the next exciting chapter of your road trip in in Italy.

Day 5 of your road trip will take you to the best attractions Rome has to offer. Cherish the 1 night you have left in Rome by discovering the best things there are to see and do in the city.

Get ready to discover some of the most iconic wonders in Rome, including a park, a public square, and a church. Start your day at Villa Borghese. This remarkable park is an impressive place to see in Rome. Then, wander over to Piazza Del Popolo. If culturally significant sites excite you, this public square will be right up your alley. Nearby, you’ll also find Spanish Steps. This visually striking public square is a favorite among visitors.

Rome offers plenty to explore, ensuring every moment of your visit is filled with excitement and discovery. If you're up for more, Piazza Di Spagna is an iconic spot in the city that will captivate you with its unique charm. When you’re done at the public square, don’t forget to check out the UNESCO world heritage-listed Basilica Di Santa Maria Maggiore. Take a moment to appreciate the fascinating details of this captivating church in Rome.

Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Rome. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Enjoy a lovely dining experience at Hotel de Russie, a popular restaurant in Rome. This acclaimed establishment has earned the admiration of countless food lovers in the city. Alternatively, experience a taste of Rome at La Taverna Italiana, another great place to eat. With a menu designed to impress, it promises a journey of flavors that will leave you captivated. A third option to check out is the top-rated The Parrot Bar. It’s yet another ideal choice to enhance your time in Rome tonight.

Cap off your dinner by heading to The Apartment Bar Roma, ideal for a leisurely evening with a drink in hand. Hotel Hassler Roma is another bar that offers an enjoyable setting.

Get a good night's sleep and look forward to another great day on the road in Italy!

Embark on another extraordinary experience on day 6 of your road trip in Italy. Today, you will make 1 stop and experience some of the highlights of Rome. At the end of the day, you will enjoy the comforts of a top-rated hotel in Naples, which will be your home away from home for 2 nights.

Today, you'll explore some of the most beautiful places in Rome, including an archeological site, a monument, a public square, a castle and much more! Start your day with a visit to Largo Di Torre Argentina. This notable archeological site is a must-visit in the city. When you’re ready for your next discovery, continue to Pantheon, which may be one of the most culturally significant places you will experience today.

One of the best things about exploring Rome on a self-guided tour is that you set the pace. There’s plenty of time for detours and discovering hidden gems. When you’re ready for your next stop, make your way to Piazza Navona, one of the city’s most globally renowned public square. If you’re up for more discoveries, don’t forget to reserve some time for Campo De' Fiori and Castel Sant'angelo.

At the end of the day, you will drive to Naples, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

As dinnertime approaches, it's time to head out for a bite to eat in Naples. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.

Experience a symphony of flavors at Veritas in Naples by securing a reservation in advance. Renowned for its 1-star Michelin distinction, Veritas delights its guests with its exceptional variety of meals showcasing delicious campanian and contemporary cuisine. For a palate-pleasing alternative, make sure to dine at Il Comandante, acclaimed for its delectable creative and mediterranean specialties. This local 1-star Michelin establishment consistently satisfies guests, ensuring an unforgettable holiday experience. Want to go on another culinary journey? Delight your senses at ARIA, a top-rated restaurant known for its outstanding menu. Known as a top-rated 1-star Michelin establishment, it's a top choice for contemporary and modern cuisine in the city.

To truly maximize your evening out, consider visiting Happening Cocktail Bar after dinner. This bar is known for offering some of the best drinks and vibes in the city. Alternatively, head to Shanti Art Musik Bar, another bar with an inviting ambiance. Similarly, Gran Caffè Gambrinus also offers a great atmosphere, ensuring a night filled with enjoyment and relaxation.

Raise your glass to another unforgettable day in Italy!

Greet day 7 of your road trip in Italy with a smile and start your day with a hearty breakfast. You will return to Naples for your remaining 1 night in the city later today, but first, it’s time for some exploring! On the agenda for this day, you’ll find only the best things to see and do in Amalfi and Naples.

Discover a day packed with fun adventures, scenic views, and photo-friendly spots in Naples. Begin your sightseeing with Castel Nuovo. This notable castle is one of the top attractions in the village. Proceed to Cappella Sansevero, another must-visit attraction that enhances the village’s allure.

As you wander through the inviting streets of Naples, soak in the lively ambiance and take the opportunity to snap some photos. Next, head to Napoli Sotterranea Percorso Ufficiale. This well-known cave system is a traveler-favorite.

When you’re done exploring the area’s best attractions, you’ll drive back to your accommodation in Naples.

After a day of adventure, treat yourself to an exquisite dinner at one of Naples's best restaurants.

Dine in style at Antica Pizzeria Di Matteo, a top recommendation for dinner tonight. Or, for a change of pace, Mercure Napoli Centro Angioino boasts a menu that's sure to impress. Also, be sure to check out La Lazzara Trattoria e Pizzeria. Known as a local hotspot, it’s a great choice for tonight in Naples.

Round off your dining experience by visiting Archivio Storico - Cocktail Bar & Wonderfood, a prime location for a drink. Alternatively, explore the distinctive characteristics of Archeobar, a bar catering to every mood and preference. Babette Pub likewise offers a unique atmosphere, perfect for a memorable night out.

Raise your glass to another unforgettable day in Italy!

On day 8 of your exciting self-drive vacation in Italy, you’ll soak in the magnificence of 2 destinations, Naples and Tivoli. When you’re not sightseeing, take time to relax at your selected hotel in Viterbo, where you’ll be staying for 1 night.

A blend of fun adventures, romantic experiences, and breathtaking views await you in Naples on today’s itinerary. First up is the spectacular public square, Piazza Del Plebiscito. It's a standout spot that offers a memorable visit. Afterward, continue to Ovo Castle. A visit to this castle is an enriching experience for all.

As you explore Naples’s charming streets, take in the lively atmosphere and get to know the character of the city. Next, make your way to Naples National Archaeological Museum. This locally renowned museum is an essential stop that should not be missed.

Tivoli’s wonders await as you prepare for another journey on the road, leaving the breathtaking surroundings of Naples behind. This drive usually takes around 2 hours 12 min. Tivoli welcomes you with a multitude of unique vacation experiences.

Head to Hadrian's Villa, an underrated archeological site in Tivoli. Explore its awe-inspiring features at your own pace before you continue your journey.

After soaking up all the sights of today's itinerary, you'll be ready to hit the road in the direction of your accommodation in Viterbo. Viterbo offers plenty of top-rated hotels and other places to stay on any travel budget. Take some time to relax before you head out to explore.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Viterbo. Enjoy a satisfying meal that will recharge you for tonight's adventures.

With its reputation for pleasing customers, it’s a fantastic choice for tonight in Viterbo.

Say good night to Viterbo and look forward to another great day of your road trip in Italy!

Dive into day 9 of your remarkable road trip in Italy. Today you will explore Orvieto, where you will have the opportunity to experience all the top things to see and do. At the end of the day, you’ll unwind at one of the finest accommodations in Florence. You’ll stay here for 2 nights.

Enjoy the perfect balance of relaxation and exploration in Orvieto today.

Throughout the day, make sure to take breaks to appreciate the surroundings.

Once you're ready to continue your road trip, it's time to buckle up and drive, eagerly anticipating your arrival in Orvieto. This drive usually takes around 53 min, without any stops or traffic disruptions.

Take your self-guided tour to Orvieto Cathedral, an interesting church that everyone visiting Orvieto should see. Enjoy sightseeing at your own pace and allow yourself time to explore the beautiful surroundings. Next, head to Orvieto Underground. This instagrammable cave system is one of the most up-and-coming attractions in the region.

Once you're ready to continue your road trip, it's time to buckle up and drive, eagerly anticipating your arrival in Orvieto. This drive usually takes around 53 min, without any stops or traffic disruptions.

Make your way to Well Of St. Patrick, a captivating monument that draws attention for its stunning features.

When you’re done exploring for the day, you’ll drive to your hotel in Florence. Check in and spend some time relaxing before you head out to tour the city.

Indulge in a memorable dining experience at one of Florence's most popular restaurants, and connect with friendly locals for an authentic adventure.

Start your culinary exploration in Florence by securing a reservation at Enoteca Pinchiorri. This renowned restaurant holds 3 Michelin star and offers an exceptional menu of italian contemporary cuisine. For another dining delight, visit Santa Elisabetta, celebrated for its delectable creative and mediterranean menu. This acclaimed 2-star Michelin-recipient consistently leaves guests satisfied, making it a must-visit during your holiday. Looking for a different experience? Discover Gucci Osteria da Massimo Bottura, a top local spot known for its tantalizing italian contemporary and international menu. With a 1-star Michelin recognition, it guarantees an exceptional dining adventure.

Keep the excitement of the evening going by visiting a bar or two. Manifattura is an excellent place to start. You could also check out Se·sto On Arno Rooftop Bar, offering a different kind of charm. A last recommendation for the day is Il Vinile. This bar promises an enjoyable experience with tasty drinks and a vibrant setting.

Relax and reminisce about your day in Italy and look forward to more memorable moments to come!

On day 10 of your road trip, you will have an entire day to explore Florence. You’ll stay in Florence for 1 night and discover all the best things to see and do in the area.

Discover a day packed with fun adventures, romantic experiences, and scenic views in Florence. Begin your sightseeing with Piazzale Michelangelo. This extraordinary observation deck is one of the top attractions in the city. Proceed to Basilica Of Santa Croce In Florence, another must-visit attraction that enhances the city’s allure.

As you wander through the inviting streets of Florence, soak in the lively ambiance and take the opportunity to snap some photos. Next, head to Piazza Della Signoria. This top-rated public square is a traveler-favorite. Not far away, you’ll find Uffizi Gallery, another key site on your sightseeing itinerary. Conclude your day at Ponte Vecchio and uncover why it's recognized as one of the city's most iconic attractions.

Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.

After a day of adventure, treat yourself to an exquisite dinner at one of Florence's best restaurants.

Don’t miss out on dining at Ditta Artigianale, a top-rated dining destination in Florence. If you're in the mood to try something new, consider Trattoria Da Burde, another top spot with a mouthwatering menu. You might also want to secure a reservation at Casa Toscana. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Florence this evening.

Unwind after your meal by stepping into Bar 50 Rosso. This venue is celebrated for its extensive drink selections and cozy vibes. Alternatively, Bitter Bar offers a dynamic and energetic atmosphere for a glass or two. Don’t overlook Archea Brewery, another top-rated bar in the area.

Head back to your accommodation in Florence and get some rest in preparation for another magical day of your road trip in Italy!

Experience an unparalleled adventure on day 11 of your road trip in Italy. This exciting part of your journey invites you to discover the renowned landmarks in 2 vibrant destinations - Florence and Siena. After a day filled with exploration and new experiences, you will retreat to the hotel of your choice in Pisa. You will spend 1 night here for some well-deserved relaxation.

Get ready to discover some of the most iconic wonders in Florence, including a church, an art gallery, and a food market. Start your day at Cathedral Of Santa Maria Del Fiore. This majestic church is an impressive place to see in Florence. Then, wander over to Galleria Dell'accademia. If heritage-rich sites excite you, this art gallery will be right up your alley. Nearby, you’ll also find Central Market. This visually striking food market is a favorite among visitors.

When you’re ready to jump back into the car and say goodbye to Florence, you’ll hit the road in the direction of Siena. This drive usually takes around 1 hour 19 min. When you arrive, enjoy some sightseeing.

Spend your afternoon discovering Piazza Del Campo, a widely recognized public square known for its enchanting features.

At the end of the day, you will drive to Pisa, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

As you explore more of Pisa, you'll discover that its culinary landscape is as diverse as its attractions. Whether you're craving traditional dishes bursting with local flavors or innovative creations that push the boundaries of taste, you're sure to find a dining experience that satisfies your cravings.

Enjoy a lovely dining experience at Ristorante Capodimonte Pisa, a popular restaurant in Pisa. This acclaimed establishment has earned the admiration of countless food lovers in the city. Alternatively, experience a taste of Pisa at La Locanda Dei Pisani Doc Pisa, another great place to eat. With a menu designed to impress, it promises a journey of flavors that will leave you captivated. A third option to check out is the top-rated Baribaldi Pisa. It’s yet another ideal choice to enhance your time in Pisa tonight.

After savoring a delicious meal, step into the vibrant nightlife at Bar Mocambo, where the evening is just getting started. In the same way, Tree offers a unique charm perfect for experiencing the local bar scene in Pisa. Chupiteria is another top-recommended bar that is sure to get you into the mood for some dancing and celebrating.

Raise your glass and celebrate another amazing day of your road trip in Italy!