12-Day Italy Road Trip from Pisa traveling south to Perugia, Rome, Viterbo, and Florence

Your road trip adventure in Italy begins as soon as you reach Pisa and pick up your car. You’ll stay in Pisa for 1 night and explore the best things to see and do, sample the local cuisine, and choose from a curated selection of the best hotels and places to stay in the city.

Pisa is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out Knights' Square or taking a stroll in the city center. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

Find your way to your hotel in Pisa. We recommend choosing a hotel in a central location for easy exploring. Check-in typically starts between 2 and 4 PM at hotels in Italy. Settle in and make plans for the evening.

As dinnertime approaches, it's time to head out for a bite to eat in Pisa. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.

Enjoy a delicious meal at Ristorante Capodimonte Pisa, a top-rated dining destination in Pisa. If you're in the mood to try something new, consider Baribaldi Pisa, another top spot with a mouthwatering menu. You might also want to secure a reservation at Restaurant -Pizzeria Il Mio Capriccio. With a reputation for consistently satisfied customers, it’s a perfect choice to enhance your stay in Pisa this evening.

Following your dinner, dive into the local bar culture at JEFFER cocktails & friends. Alternatively, go to Le Parisien Wine Bar, the perfect place for those looking to experience the best of the nightlife. Similarly, Las Volta cocktailbar provides excellent drinks and a great atmosphere, ensuring a memorable night out.

Raise a toast to the start of your 12-day road trip in Italy!

Embark on another extraordinary experience on day 2 of your road trip in Italy. Today, you will make 2 stops and experience some of the highlights of Pisa and Cascine Vecchie. At the end of the day, you will enjoy the comforts of a top-rated hotel in Perugia, which will be your home away from home for 1 night.

Embrace the thrill of the open road as you wave goodbye to Pisa and set your GPS to Perugia. While on the road, immerse yourself in your favorite road trip tunes or sample the sounds from a local radio station. This car ride usually takes around 2 hours 49 min. Upon reaching Perugia, unwind, observe, and explore. The best things to do, see, and eat are waiting for you.

Be one of the day’s first visitors at Leaning Tower of Pisa. This bell tower is rated an average of 4.7 out of 5 stars by 116,882 visitors. Attracting more than 3,200,000 yearly visitors, it’s a top sight you don’t want to miss.

When you’re finished at Leaning Tower of Pisa, head to Pisa Cathedral. This one-of-a-kind cathedral is rated an average of 4.8 out of 5 stars in 8,361 reviews.

Beyond the above-mentioned attractions, you also have the opportunity to visit Piazza del Duomo, Pisa. This square is rated an average of 4.7 out of 5 stars by 104,550 visitors.

If you’re keen to explore more, then consider a visit to Campo santo. This cemetery is a much-appreciated attraction with an average rating of 4.6 out of 5 stars from 586 visitors.

An excellent attraction to start your day with is Parco Regionale Migliarino, San Rossore, Massaciuccoli. This park is rated an average of 4.4 out of 5 stars in 9,632 reviews.

When you’re done exploring for the day, you’ll drive to Perugia, where you'll have a hotel waiting for you. Check in and spend some time relaxing before you head out to explore the city.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Perugia.

Savor the flavors at Ristorante Settimo Sigillo, a top pick for dinner tonight. Alternatively, Bar Pellas beckons with its unique menu offerings. Also, consider La Taverna. With its consistent customer satisfaction, it’s an excellent option for dining in Perugia tonight.

Explore the vibrant nightlife at Tommi Bar after your meal, a hub for lively evenings and memorable moments. Or, head to Valentina for a great selection of flavorful drinks and a charming setting. Furthermore, Caffe Dal Perugino is perfect for those looking to extend their night with a touch of local flavor.

Take some time to reflect on your day and savor another beautiful night in Italy.

On day 3 of your exciting self-drive vacation in Italy, you’ll soak in the magnificence of 1 destination, Santa Maria degli Angeli. When you’re not sightseeing, take time to relax at your selected hotel in Rome, where you’ll be staying for 5 nights.

Once you're ready to continue your road trip, it's time to buckle up and drive, eagerly anticipating your arrival in Santa Maria degli Angeli. This drive usually takes around 32 min, without any stops or traffic disruptions.

Start your sightseeing with a visit to Basilica of San Francesco d'Assisi. This papal basilica is rated an average of 4.9 out of 5 stars from 33,258 visitors.

Piazza del Comune is another popular attraction you could visit today. This point of interest has a rating of 4.6 out of 5 stars from 3,057 visitors.

Basilica di Santa Chiara is also highly recommended by travelers. This minor basilica has a rating of 4.7 out of 5 stars from 9,628 visitors.

Embrace the thrill of the open road as you wave goodbye to Santa Maria degli Angeli and set your GPS to Santa Maria degli Angeli. While on the road, immerse yourself in your favorite road trip tunes or sample the sounds from a local radio station. This car ride usually takes around 11 min. Upon reaching Santa Maria degli Angeli, unwind, observe, and explore. The best things to do, see, and eat are waiting for you.

Be one of the day’s first visitors at Basilica of Santa Maria degli Angeli. This papal basilica is rated an average of 4.8 out of 5 stars by 19,258 visitors.

At the end of the day, you will drive to Rome, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

After a day of adventure, treat yourself to an exquisite dinner at one of Rome's best restaurants.

Treat yourself to an extraordinary dining experience at La Pergola, a 3-star Michelin restaurant offering an incredible mediterranean and contemporary menu. Alternatively, if your taste buds call for something different, Il Pagliaccio is one of the best restaurants for creative and innovative cuisine in Rome. This 2-star Michelin-awardee earns consistently high praises from guests. We also recommend checking out the menu at Enoteca La Torre. As a top-rated it is an ideal choice for mediterranean and creative cuisine in the city.

Keep the excitement of the evening going by going to a bar or two. La Botticella of Poggi Giovanni is an excellent place to start. You could also check out Sant' Eustachio Caffè, offering a different kind of charm. A last recommendation for the day is Caffè Portofino. This bar promises an enjoyable experience with tasty drinks and a vibrant setting.

Head back to your accommodation in Rome and get some rest in preparation for another magical day of your road trip in Italy!

On day 4 of your road trip, you will have an entire day to explore Vatican City. You’ll stay in Vatican City for 4 nights and discover all the best things to see and do in the area.

There are plenty of experiences you can choose from in Italy that will add excitement to your vacation. When you’re keen to discover what else Vatican City has in store for you, use this day to go on a tour. This tour allows curious travelers like you to experience the best of the country. You can make the most of your time in Italy by scrolling down and selecting tours and activities to include on your itinerary for the day.

Indulge in a memorable dining experience at one of Rome's most popular restaurants, and connect with friendly locals for an authentic adventure.

Enjoy a delicious meal at DEROMA - Farine Romane, a top-rated dining destination in Rome. If you're in the mood to try something new, consider La Taverna Italiana, another top spot with a mouthwatering menu. You might also want to secure a reservation at Centro. With a reputation for consistently satisfied customers, it’s a perfect choice to enhance your stay in Rome this evening.

Following your dinner, dive into the local bar culture at The Apartment Bar Roma. Alternatively, go to Hotel Hassler Roma, the perfect place for those looking to experience the best of the nightlife.

Raise your glass and celebrate another amazing day of your road trip in Italy!

Day 5 offers a multitude of experiences. You will stay in Rome for 3 nights more, offering you enough time to explore at a relaxed pace.

When you're ready to see some sights, Circus Maximus is a great place to start. This circus is rated an average of 4.4 out of 5 stars by 44,741 visitors.

Another popular attraction you can visit today is Pantheon. This roman temple has an average rating of 4.8 out of 5 stars from 189,682 travelers. Every year, 30,000,000 travelers come to experience this site to make the most of their time in Rome.

We also recommend a stop at Piazza Navona. The square has been rated an average of 4.7 out of 5 stars by 158,771 visitors.

If you're keen to explore more, consider visiting Campo de' Fiori. This square is a popular attraction with an average rating of 4.4 out of 5 stars from 51,133 reviews.

Castel Sant'Angelo is another easily accessible place to visit on this day of your trip. Stop by this museum, rated 4.7 out of 5 stars in 72,431 reviews, to discover more of what makes it unique. This attraction gets 918,591 visitors every year.

Don’t forget to check out all the popular tours and activities you can add to your travel plan. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.

As dinnertime approaches, it's time to head out for a bite to eat in Rome. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.

Have a fantastic dining experience at Ristorante Tema, a highly recommended choice for tonight's dinner. If you're looking to mix things up, Maccheroni offers an enticing alternative with its varied menu. Additionally, RoYaL Art Cafè Roma is worth considering. Renowned for satisfying diners, it’s an ideal option for tonight in Rome.

As the day draws to a close, take a moment to unwind and prepare for the next exciting chapter of your road trip in in Italy.

Day 6 of your road trip will take you to the best attractions Rome has to offer. Cherish the 2 nights you have left in Rome by discovering the best things there are to see and do in the city.

Make Villa Borghese your first stop of the day. Previous visitors have rated this urban zone of rome an average of 4.6 out of 5 stars in 69,749 reviews.

Next up, make a stop at piazza del Popolo. With an average rating of 4.6 out of 5 stars by 89,807 visitors, it's easy to understand why so many people visit this square every year.

Spanish Steps is another attraction you can visit on this day of your vacation. This monumental staircase has an average rating of 4.5 out of 5 stars by 57,211 visitors.

When you’re finished at Spanish Steps, the perfect next stop is Piazza di Spagna. This square is rated an average of 4.7 out of 5 stars in 113,658 reviews.

If you’re keen to explore even more, then consider a visit to Trevi Fountain. This sculpture is a top place to visit, with a rating of 4.8 out of 5 stars from 343,494 reviews.

You can learn more about Rome today by going on a tour. Rome offers many top-rated tours and unique experiences that will inspire you. You can browse and select your favorites below.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Rome. Enjoy a relaxing evening as you savor delicious local cuisine and reflect on the day's adventures.

Dine in style at Harry's Bar, a top recommendation for dinner tonight. Or, for a change of pace, Ristorante Amedeo boasts a menu that's sure to impress. Also, be sure to check out VinAllegro. Known as a local hotspot, it’s a great choice for tonight in Rome.

Head back to your accommodation in Rome and get some rest in preparation for another magical day of your road trip in Italy!

Day 7 of your road trip across Italy promises a magnificent time exploring Rome. You have 1 night left in Rome. Take the opportunity to experience more of the best attractions and activities in the city.

Begin your sightseeing with a visit to largo di Torre Argentina. This extraordinary square is rated an average of 4.5 out of 5 stars by 30,433 visitors.

Next, make your way to Altare della Patria. This top attraction is an architectural structure with an average rating of 4.8 out of 5 stars by 49,843 visitors. Altare della Patria welcomes 1,683,070 yearly visitors.

We also recommend a visit to Roman Forum. This square is rated 4.7 out of 5 stars by 114,450 travelers.

If you’re keen to keep exploring, visit Colosseum. This highly recommended sightseeing destination has received an average rating of 4.7 out of 5 stars from 328,821 travelers. Around 7,400,000 people come to experience this place of interest every year.

Today is also your chance to spend some time at Basilica di Santa Maria Maggiore. This major basilica is rated an average of 4.8 out of 5 stars by 27,678 travelers.

Immerse yourself in the local scene through top-rated tours and activities. You can choose from a wide variety of easy to challenging tours and easily add them to your travel package below.

As you explore more of Rome, you'll discover that its culinary landscape is as diverse as its attractions. Whether you're craving traditional dishes bursting with local flavors or innovative creations that push the boundaries of taste, you're sure to find a dining experience that satisfies your cravings.

Treat yourself to a delightful dinner at Cantina e Cucina, highly recommended for tonight's dining. Or, if you're feeling adventurous, why not try Bono Bottega Nostrana - Piazza Di Spagna? It's another excellent option with a diverse menu. Consider reserving a table at Ai Tre Scalini as well. Known for its consistent customer satisfaction, it’s an ideal pick for tonight in Rome.

Relax and reminisce about your day in Italy and look forward to more memorable moments to come!

Experience an unparalleled adventure on day 8 of your road trip in Italy. This exciting part of your journey invites you to discover the renowned landmarks in 1 vibrant destinations - Orvieto. After a day filled with exploration and new experiences, you will retreat to the hotel of your choice in Viterbo. You will spend 1 night here for some well-deserved relaxation.

Orvieto’s wonders await as you prepare for another journey on the road, leaving the breathtaking surroundings of Rome behind. This drive usually takes around 1 hour 38 min. Orvieto welcomes you with a multitude of unique vacation experiences.

Start your sightseeing with a visit to Orvieto Cathedral. This catholic cathedral is a popular stop on travelers’ itineraries in Orvieto, with an average rating of 4.8 out of 5 stars by 15,057 visitors.

Torre del Moro Orvieto is another popular place of interest you can visit today. The average rating of 4.5 out of 5 stars from 740 reviews gives you an idea of other visitors’ experience at this attraction.

If it’s still bright and early, make your way to Pozzo della Cava. Visitors have rated this objet du musée d'archéologie an average of 4.6 out of 5 stars in 1,403 reviews. Pozzo della Cava receives around 20,336 visitors every year.

Once you're ready to continue your road trip, it's time to buckle up and drive, eagerly anticipating your arrival in Orvieto. This drive usually takes around 1 hour 38 min, without any stops or traffic disruptions.

A top pick for your self-guided sightseeing tour today is Well of St. Patrick. Previous visitors have rated this point of interest an average of 4.5 out of 5 stars in 14,274 reviews.

After soaking up all the sights of today's itinerary, you'll be ready to hit the road in the direction of Viterbo. Viterbo offers plenty of top-rated hotels and other places to stay on any travel budget. Check in at the hotel of your choice and take some time to relax before you head out to explore.

Indulge in a memorable dining experience at one of Viterbo's most popular restaurants, and connect with friendly locals for an authentic adventure.

As the day draws to a close, take a moment to unwind and prepare for the next exciting chapter of your road trip in in Italy.

Dive into day 9 of your remarkable road trip in Italy. Today you will explore Tiro a Segno and Collestatte, where you will have the opportunity to experience all the top things to see and do. At the end of the day, you’ll unwind at one of the finest accommodations in Florence. You’ll stay here for 2 nights.

Fasten your seatbelt and make your way to your next stop. Tiro a Segno, home to many well-known sights in the region, is a lovely destination on today’s itinerary. Keep in mind that your travel time from Viterbo to Tiro a Segno may take around 51 min without traffic disruptions. Upon arrival in Tiro a Segno, we highly recommend checking out some of the top attractions.

Begin your sightseeing with a visit to Piazzale Byron. This extraordinary sightseeing destination is rated an average of 4.7 out of 5 stars by 117 visitors.

Next, make your way to Punto panoramico alla base delle cascate delle Marmore. This top attraction is a park with an average rating of 4.7 out of 5 stars by 1,207 visitors.

We also recommend a visit to Belvedere "Pennarossa" della Cascata delle Marmore. This sightseeing destination is rated 4.8 out of 5 stars by 3,428 travelers.

Set your GPS to Collestatte and hit the road. Expect a journey of approximately 2 min without stops. Soak in the beautiful landscapes as you drive and look forward to exploring your next destination. Collestatte beckons with new experiences!

Begin your sightseeing with a visit to Parco Fluviale del Nera. This park is rated an average of 4.7 out of 5 stars in 15,518 reviews.

When you’re done exploring for the day, you’ll drive to Florence, where you'll have a hotel waiting for you. Check in and spend some time relaxing before you head out to explore the city.

As you explore more of Florence, you'll discover that its culinary landscape is as diverse as its attractions. Whether you're craving traditional dishes bursting with local flavors or innovative creations that push the boundaries of taste, you're sure to find a dining experience that satisfies your cravings.

Begin your culinary exploration in Florence by securing a reservation at Enoteca Pinchiorri. This renowned restaurant offers an exceptional menu of italian contemporary cuisine. For another dining delight, visit Santa Elisabetta, celebrated for its delectable creative and mediterranean menu. This acclaimed 2-star Michelin-recipient consistently leaves guests satisfied, making it a must-visit during your holiday. Looking for a different experience? Discover Gucci Osteria da Massimo Bottura, a top local spot known for its tantalizing italian contemporary and international menu. With a 1-star Michelin recognition, it guarantees an exceptional dining adventure.

Continue your lively evening at Manifattura, a perfect place for winding down or revving up the night, depending on which mood you’re in. SE·STO on Arno Rooftop Bar is another excellent bar that offers a great selection of drinks to suit any mood. If you prefer to go somewhere else, Archea Brewery ensures a night out tailored to your taste.

Savor another day of unforgettable experiences in Italy!

On day 10 of your road trip, you will have an entire day to explore Florence. You’ll stay in Florence for 1 night and discover all the best things to see and do in the area.

Be one of the day’s first visitors at piazzale Michelangelo. This square is rated an average of 4.8 out of 5 stars by 77,744 visitors.

When you’re finished at piazzale Michelangelo, head to Uffizi Gallery. This one-of-a-kind national museum is rated an average of 4.7 out of 5 stars in 61,794 reviews. Every year, approximately 2,011,219 travelers come here to experience the national museum for themselves.

Beyond the above-mentioned attractions, you also have the opportunity to visit Ponte Vecchio. This deck arch bridge is rated an average of 4.7 out of 5 stars by 118,099 visitors.

If you’re keen to explore more, then consider a visit to piazza della Signoria. This square is a much-appreciated attraction with an average rating of 4.8 out of 5 stars from 66,956 visitors.

To round off your sightseeing experience, make your way to Galleria dell'Accademia. This famous national museum welcomes around 1,719,645 visitors annually and is rated an average of 4.6 out of 5 stars by 34,429 travelers.

Your discoveries in Florence do not have to stop there. Check out the fantastic selection of tours and tickets offered in Florence on this day of your trip. You can select your tours below.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Florence.

This renowned restaurant holds , and offers an exceptional menu of cuisine. Make sure to reserve a table at Trattoria Da Burde, an iconic dining spot in Florence. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Ristorante Buca Mario, a popular restaurant in Florence. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of Eataly Firenze, a hidden gem nestled in Florence. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

Raise your glass to another unforgettable day in Italy!

On day 11 of your road trip in Italy, you will get a true taste of the freedom a self-drive vacation in Europe entails. Today’s travel plans include stops at the most scenic, wondrous, and interesting places in Florence and Siena. In the evening, you’ll end up in Pisa, where you will stay for 1 night.

When you’re ready to jump back into the car and say goodbye to Florence, you’ll hit the road in the direction of Siena. This drive usually takes around 1 hour 19 min. When you arrive, enjoy some sightseeing.

When you’re ready for some sightseeing, make your way to Cathedral of Santa Maria del Fiore. This much-appreciated church is rated 4.8 out of 5 stars in 76,359 reviews.

Next up is Central Market. This sightseeing destination has an average rating of 4.4 out of 5 stars from 43,100 visitors.

Fasten your seatbelt and make your way to your next stop. Siena, home to many well-known sights in the region, is a lovely destination on today’s itinerary. Keep in mind that your travel time from Florence to Siena may take around 1 hour 19 min without traffic disruptions. Upon arrival in Siena, we highly recommend checking out some of the top attractions.

Take the opportunity to see piazza del Campo. This attraction has an average rating of 4.8 out of 5 stars from 64,175 visitors.

Siena Cathedral is another sightseeing hotspot in the area. This domus has been rated an average of 4.8 out of 5 stars by 21,656 travelers.

At the end of the day, you will drive to Pisa, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Pisa. Enjoy a relaxing evening as you savor delicious local cuisine and reflect on the day's adventures.

Enjoy a delicious meal at Ristorante alle Bandierine, a highly-rated dining destination in Pisa. If you're eager to try something different, consider Barrique Cocktail And Bistrot, another top spot with a tantalizing menu. You might also want to secure a reservation at Filter Coffee Lab. With a reputation for consistently satisfied customers, it’s an excellent choice to enhance your stay in Pisa this evening.

After savoring a delicious meal, step into the vibrant nightlife at Bar Mocambo, where the evening is just getting started. In the same way, Tree offers a unique charm perfect for experiencing the local bar scene in Pisa. Chupiteria is another top-recommended bar that is sure to get you into the mood for some dancing and celebrating.

Raise your glass to another unforgettable day in Italy!

Day 12 of your road trip in Italy is your departure day. This is your chance to catch a last glimpse of Pisa before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

Maximize your last day in Italy and go on a shopping spree in Pisa’s shopping center. This bustling commercial district is conveniently located near your lodging, granting you leisure time to roam and explore its assortment of establishments.

If you love the adrenaline rush of hunting for the best offers and deals in Italy, you’re in for a treat. A variety of goods and gifts await your discovery. Bring a bit of Italy home with you through these charming souvenirs.

Before you conclude your road trip in Italy, drop by another restaurant for a last chance at a memorable dining experience in Pisa.

If you're in the mood to try something new, consider Kiste' - La Pizza Artigianale. It's the second restaurant coming from the tower. , another top spot with a mouthwatering menu.

You’ll then say farewell to Pisa. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Italy!