12-Day Italy Self-Drive Road Trip With Itinerary from Rome to Florence, Lucca, La Spezia, Bologna, and Venice

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Photo of piazza de spagna in Rome, Italy.
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Explore the best of Italy on a remarkable 12-day road trip! Combine exploration with relaxation on a self-drive tour featuring Rome, Florence, Pisa, Lucca, Riomaggiore, La Spezia, Manarola, Corniglia, Bologna, and Venice.

This perfectly planned road trip itinerary takes you through some of the best places to see in Italy. You will spend 3 nights in Rome, 2 nights in Florence, 1 night in Lucca, 2 nights in La Spezia, 2 nights in Bologna, and 1 night in Venice. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Italy. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have you covered.

Upon arriving in Rome, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Italy on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Italy. Trevi Fountain and Colosseum are just a couple of the bucket-list attractions that await your discovery. Marvel at the remarkable Pantheon, learn more about the unique Piazza Navona, and immerse yourself in the vibrant atmosphere of Piazza San Marco.

As you hit the open road and drive through Rome, Florence, Pisa, Lucca, Riomaggiore, La Spezia, Manarola, Corniglia, Bologna, and Venice, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Italy. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Italy.

Throughout your road trip in Italy, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Italy.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodations, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in Italy fill up quickly, so book your spot early. Select a date and start planning your road trip in Italy today!

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Day 1

Day 1

  • Rome - Arrival day
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  • Piazza Navona
  • More

Welcome to Rome, the perfect starting point for your road trip in Italy! Pick up your rental car and let the adventure begin. You will spend 2 nights discovering what to see in Rome before embarking on the next leg of your journey.

Rome is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out Piazza Navona, or just taking a stroll in the city center. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

When you're ready for some downtime, make your way to your chosen hotel. Check-in typically starts between 2 and 4 PM in Rome. Make yourself at home and unwind before heading out again.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Rome, it's often a good idea to reserve a table in advance.

Treat yourself to a delightful dinner at La Bottega Roma, highly recommended for tonight's dining. Or, if you're feeling adventurous, why not try Pasta In Corso? It's another excellent option with a diverse menu. Consider reserving a table at Trattoria Vecchia Roma as well. Known for its consistent customer satisfaction, it’s an ideal pick for tonight in Rome.

Round off your dining experience by visiting La Botticella Of Poggi Giovanni, a prime location for a drink. Alternatively, explore the distinctive characteristics of Almalu Trastevere, a bar catering to every mood and preference. Bar Viminale Di Pepi Maurilio likewise offers a unique atmosphere, perfect for a memorable night out.

Raise a toast to the start of your 12-day road trip in Italy!

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Day 2

Day 2

  • Rome
  • More

Drive 10 km, 1 hour 22 min

  • Colosseum
  • Roman Forum
  • Trevi Fountain
  • Spanish Steps
  • Villa Borghese
  • Monti
  • More

Day 2 of your road trip across Italy promises a magnificent time exploring what to see in Rome. You have 1 night left in Rome. Take the opportunity to experience more of the best attractions and activities in the city.

Whether you decide to explore Rome on foot, use public transport, or join a guided tour, there are a few attractions you don’t want to miss. Make sure to visit Monti, a popular neighborhood in Rome. Spend some time wandering around the area and soak in its distinctive charm. You’ll also discover that several of the city’s must-see attractions are just around the corner.

Check out the wondrous archeological site, Colosseum. Afterward, continue to Roman Forum, an archeological site every traveler should visit. As you explore Rome’s charming streets, take in the lively atmosphere and get to know the character of the city.

Next, make your way to Trevi Fountain. This globally renowned monument is an essential stop. Following that, head to Spanish Steps, another must-visit site that will enhance your experience. Don’t forget to stop by Villa Borghese, a top-rated park in the city.

Don’t forget to check out all the popular tours and experiences you can add to your travel plans in Italy. You can explore and select activities under each day of your itinerary.

Indulge in a memorable dining experience at one of Rome's most popular restaurants, and connect with friendly locals for a true cultural experience.

Don’t miss out on dining at RomAntica, a top-rated dining destination in Rome. If you're in the mood to try something new, consider Coso Ristorante, another top spot with a mouthwatering menu. You might also want to secure a reservation at DEROMA - Farine Romane. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Rome this evening.

Cap off your dinner by heading to Sant' Eustachio Caffè, ideal for a leisurely evening with a drink in hand. Yellowsquare Rome is another bar that offers an enjoyable setting. Similarly, Caffè Portofino is also a popular place to go on a night out, perfect for relaxing and socializing.

Savor another day of unforgettable experiences in Italy!

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Day 3

Day 3

  • Rome
  • Florence
  • More

Drive 278 km, 3 hours 22 min

  • Bargello National Museum
  • Uffizi Gallery
  • Ponte Vecchio
  • Loggia dei Lanzi
  • Palazzo Vecchio
  • piazza della Signoria
  • More

On day 3 of your exciting self-drive vacation in Italy, you’ll soak in the magnificence of 1 destination, including Florence. When you’re not sightseeing, take time to relax at your chosen hotel in Florence, where you’ll be staying for 2 nights.

Whatever your travel style is, Bargello National Museum is an essential stop in Rome. This intriguing museum provides an insightful glimpse into the city's identity. Next, discover Uffizi Gallery, a historic art gallery, promising a delightful encounter.

Continue your sightseeing with a visit to Ponte Vecchio, a globally renowned historical landmark. When you’re done, don’t forget to make a stop at the curiosity-inducing Loggia Dei Lanzi. Not far away from the public square, you will find the grand Piazza Della Signoria, perfect for a quick visit. Round off your day at Palazzo Vecchio, another gem in Rome with respected features to discover.

At the end of the day, you will drive to Florence, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

Florence is a place where the culinary landscape is as diverse as its attractions. So before the day ends, treat your palate to a taste of local cuisine at one of the best restaurants in Florence.

Have a fantastic dining experience at Ristorante Oliviero 1962, a highly recommended choice for tonight's dinner. If you're looking to mix things up, Di Poneta Novoli offers an enticing alternative with its varied menu. Additionally, Caffe San Firenze is worth considering. Renowned for satisfying diners, it’s an ideal option for tonight in Florence.

Cap off your culinary experience with a visit to some of the most celebrated bars in the area. For instance, Manifattura stands out as an excellent choice for a post-dinner cocktail. Alternatively, Se·sto On Arno Rooftop Bar offers an ideal atmosphere to enjoy the pleasures of the night. Il Vinile is also a great option that provides a perfect setting for a relaxing evening.

Raise your glass to another unforgettable day in Italy!

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Day 4

Day 4

  • Florence
  • More

Drive 8 km, 1 hour 14 min

  • Central Market
  • Galleria dell'Accademia
  • Cathedral of Santa Maria del Fiore
  • Basilica of Santa Croce in Florence
  • piazzale Michelangelo
  • Oltrarno
  • More

On day 4 of your road trip, you will have an entire day to discover what to see in Florence. You’ll stay in Florence for 1 night.

A top thing to do today is to explore Oltrarno, a must-see neighborhood in Florence. It's the perfect starting point for touring the top attractions in the area.

Central Market is an ideal stop early in the day. This interesting food market is a must-visit in the city. When you’re ready for your next discovery, continue to Galleria Dell'accademia, which may be one of the most eye-catching places you will experience today.

One of the best things about exploring Florence on a self-guided tour is that you set the pace. There’s plenty of time for detours and discovering hidden gems. When you’re ready for your next stop, make your way to Cathedral Of Santa Maria Del Fiore, a famous church in the city. If you’re up for more discoveries, don’t forget to reserve some time for Basilica Of Santa Croce In Florence and Piazzale Michelangelo.

Don’t forget to check out all the popular tours and experiences you can add to your travel plans in Italy. You can explore and select activities under each day of your itinerary.

After a day of adventure, treat yourself to an exquisite dinner at one of Florence's best restaurants.

Dine in style at Ditta Artigianale, a top recommendation for dinner tonight. Or, for a change of pace, Trattoria Da Burde boasts a menu that's sure to impress. Also, be sure to check out Casa Toscana. Known as a local hotspot, it’s a great choice for tonight in Florence.

Following your dinner, dive into the local bar culture at Bar 50 Rosso. Enjoy this evening's relaxed ambiance with delightful drinks. Alternatively, go to Bitter Bar, the perfect place for those looking to experience the best of the nightlife. Similarly, Archea Brewery provides excellent drinks and a great atmosphere, ensuring a memorable night out.

As the sun sets, rest up and recharge for the next leg of your road trip in Italy.

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Day 5

Day 5

  • Florence
  • Lucca
  • More

Drive 107 km, 2 hours 11 min

  • Campo santo
  • Piazza del Duomo, Pisa
  • Pisa Cathedral
  • Leaning Tower of Pisa
  • Walls of Lucca
  • Piazza dell'Anfiteatro
  • More

Your itinerary for day 5 of your road trip in Italy includes 2 stops and features some of the highlights of Pisa and Lucca. At the end of the day, enjoy the comforts of a top-rated hotel in Lucca, where you'll spend 1 night.

Campo Santo is perfect for a self-paced visit during the day. This breathtaking cemetery is sure to impress. Next on your list is Piazza Del Duomo, Pisa, another must-visit landmark and iconic public square renowned for its UNESCO world heritage-listed features.

While exploring and sightseeing, take time to savor the culture of Florence by sampling some local delicacies. When you’re ready for more sightseeing, head to Pisa Cathedral. This majestic church is an essential place to visit for anyone looking for the full Florence experience. We also recommend visiting Leaning Tower Of Pisa, a timeless monument. Nearby, you'll also find Mura Di Lucca, ready to add charm to your journey. End your self-guided sightseeing tour with a stop at Piazza Dell'anfiteatro and wrap up your day with its romantic appeal.

When you’re done exploring for the day, you’ll drive to your hotel in Lucca. Check in and relax before you head out to tour the city.

Indulge in a memorable dining experience at one of Lucca's most popular restaurants, and connect with friendly locals for a true cultural experience.

Enjoy a delicious meal at Gli Orti di Via Elisa, a top-rated dining destination in Lucca. If you're in the mood to try something new, consider Bar Caffè Ristretto, another top spot with a mouthwatering menu. You might also want to secure a reservation at Ristorante Schiaffino. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Lucca this evening.

Explore the vibrant nightlife at Lebowski - Cocktail Bar after your meal, a hub for lively evenings and memorable moments. Or, head to Blend for a great selection of flavorful drinks and a charming setting. Furthermore, Franklin'33 is perfect for those looking to extend their night with a touch of local flavor.

Get a good night's sleep and look forward to another great day on the road in Italy!

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Day 6

Day 6

  • Lucca
  • La Spezia
  • More

Drive 104 km, 2 hours

  • Castle of Riomaggiore
  • Riomaggiore
  • Church of San Giovanni Battista of Riomaggiore
  • More

On day 6 of your road trip in Italy, your travel plans include 1 stop at the most scenic, wondrous, and interesting places in the region. Riomaggiore are on today's agenda. In the evening, you’ll end up in La Spezia, where you will stay for 2 nights.

Catch Castle Of Riomaggiore before the crowds roll in. This romantic castle is sure to ignite your curiosity.

In between sights, stop by local stores, picturesque photo spots, and small eateries. When you’re ready for your next attraction, proceed to Church Of San Giovanni Battista Of Riomaggiore, an up-and-coming church.

After soaking up all the sights on today's itinerary, you'll be ready to head to your accommodation in La Spezia. La Spezia offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in La Spezia, it's often a good idea to reserve a table in advance.

Treat yourself to a delightful dinner at The Colombaio Park, highly recommended for tonight's dining.

Relax and look forward to more memorable moments to come!

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Day 7

Day 7

  • La Spezia
  • More

Drive 57 km, 1 hour 46 min

  • Manarola Overlook Viewpoint
  • Cinque Terre National Park
  • Sentiero Azzurro
  • More

Greet day 7 of your road trip in Italy with a smile and start your day with a hearty breakfast. You have 1 night to stay in La Spezia, so get ready to make the most of your time in the region. On the agenda for this day, you’ll find only the best things to see and do in Manarola and Corniglia.

Start your day at Manarola Overlook Viewpoint. This stunning observation deck is a beloved place to see in La Spezia. Then, wander over to Cinque Terre National Park. If UNESCO world heritage-listed sites excite you, this national park will be right up your alley. Nearby, you’ll also find Sentiero Azzurro. This mesmerizing hiking area is a favorite among visitors.

When you’re done exploring for the day, you’ll return to La Spezia and your accommodation.

Indulge in a memorable dining experience at one of La Spezia's most popular restaurants, and connect with friendly locals for a true cultural experience.

Raise your glass and celebrate another amazing day of your road trip in Italy!

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Day 8

Day 8

  • La Spezia
  • Bologna
  • More

Drive 220 km, 2 hours 49 min

  • Pinacoteca Nazionale di Bologna
  • Palazzo Grassi, Bologna
  • Bologna Cathedral
  • Fountain of Neptune, Bologna
  • Piazza Maggiore
  • Palazzo d'Accursio
  • More

Experience an unparalleled adventure on day 8 of your road trip in Italy. This exciting part of your journey invites you to discover the renowned landmarks in 1 place, which are Bologna. At the end of the day, you will retreat to the hotel of your choice in Bologna, where will spend 2 nights.

Pinacoteca Nazionale Di Bologna brings La Spezia's character to life. This eye-catching art gallery is a highlight of any visit in the city. Next, head over to Bologna Cathedral, one of the city’s most underrated attractions, known for its grand features.

If you’re looking for more, spend time soaking in the atmosphere of Fountain Of Neptune, Bologna. This instagrammable monument is frequented by locals and tourists alike. To complete your memorable day, make sure to visit Piazza Maggiore, a widely recognized public square, and take a stroll around the area. If you want to extend your self-guided sightseeing tour, go check out Palazzo D'accursio before you head back to your hotel.

At the end of the day, you will drive to Bologna, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Bologna. Enjoy a relaxing evening as you savor delicious local cuisine.

Dine in style at Ristorante Ciacco, a top recommendation for dinner tonight. Or, for a change of pace, Ristorante Ballarini boasts a menu that's sure to impress. Also, be sure to check out Sfoglia Rina. Known as a local hotspot, it’s a great choice for tonight in Bologna.

After savoring a delicious meal, step into the vibrant nightlife at Bar Al Bricco D'oro, where the evening is just getting started. In the same way, Bar Freud E Squisito offers a unique charm perfect for experiencing the local bar scene in Bologna. Osteria Del Sole is another top-recommended bar that is sure to get you into the mood for some dancing and celebrating.

Relax and recharge in preparation for another adventurous day in Italy!

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Day 9

Day 9

  • Bologna
  • More

Drive 3 km, 42 min

  • Two Towers
  • Piazza Santo Stefano
  • Portici di Bologna
  • Porta Castiglione
  • More

Day 9 offers an itinerary packed with the best things to see in Bologna. You’ll stay in Bologna for 1 night more, offering you enough time to explore at a relaxed pace.

Enjoy all that Two Towers has to offer. This is a notable monument you should not miss. Another must-see is Piazza Santo Stefano, an up-and-coming public square in Bologna.

When you’re ready for the next sight, head to Portici Di Bologna. From there, take a leisurely stroll to Porta Castiglione, another of the city’s up-and-coming attractions.

Don’t forget to check out all the popular tours and experiences you can add to your travel plans in Italy. You can explore and select activities under each day of your itinerary.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Bologna, it's often a good idea to reserve a table in advance.

Enjoy a delicious meal at Bononia Cafè, a highly-rated dining destination in Bologna. If you're eager to try something different, consider Via Con Me, another top spot with a tantalizing menu. You might also want to secure a reservation at Trattoria Pizzeria La Mela. With a reputation for consistently satisfying customers, it’s an excellent choice to enhance your stay in Bologna this evening.

Round off your dining experience by visiting Lime Bar, a prime location for a drink. Alternatively, explore the distinctive characteristics of Macondo - Cocktail Bar, a bar catering to every mood and preference. Bar Onda Marina By Night likewise offers a unique atmosphere, perfect for a memorable night out.

As the day draws to a close, take a moment to unwind and prepare for the next exciting chapter of your road trip in Italy.

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Day 10

Day 10

  • Bologna
  • Venice
  • More

Drive 162 km, 2 hours 54 min

  • Bridge of Sighs
  • Doge's Palace
  • St Mark's Basilica
  • St Mark's Campanile
  • Piazza San Marco
  • Grassi Palace
  • More

Dive into day 10 of your remarkable road trip in Italy. Today you'll explore 1 destination, including Venice. At the end of the day, you’ll unwind at one of the finest accommodations in Venice, where you'll spend 1 night.

Bridge Of Sighs is must-visit monument and a great option for a daytime tour of the area. Continue your journey to Doge's Palace, a locally renowned palace, located just a leisurely stroll away. Next, head to St Mark's Basilica, a history-steeped church, also available for your discovery today.

Each stop on today’s itinerary promises to leave you with lasting memories and a deeper appreciation for Bologna. When you're ready, let your sightseeing route take you to the up-and-coming St Mark's Campanile. If you’re looking for more, Piazza San Marco is also an iconic attraction that is worthwhile a visit. Lastly, don’t miss Grassi Palace, a place of enchanting interest in the city.

When you’re done exploring for the day, you’ll drive to your hotel in Venice. Check in and relax before you head out to tour the city.

After a day of adventure, treat yourself to an exquisite dinner at one of Venice's best restaurants.

Don’t miss out on dining at Bauer Hotel, a top-rated dining destination in Venice. If you're in the mood to try something new, consider L'Osteria Le Guglie, another top spot with a mouthwatering menu. You might also want to secure a reservation at Corner Pub. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Venice this evening.

After enjoying a delightful dinner, why not delve into the vibrant local bar scene? You might want to spend the evening at Al Parlamento, a well-loved spot among locals and tourists. Or, head to The Caffe Rosso. This bar boasts a welcoming environment that is perfect for winding down. You could also continue your night at Adagio, another top-rated place in the area.

Take some time to reflect on your day and savor another beautiful night in Italy.

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Day 11

Day 11

  • Venice
  • Rome
  • More

Drive 541 km, 6 hours 15 min

  • Rialto Bridge
  • Palazzo Contarini del Bovolo
  • Campo Sant'Angelo
  • Peggy Guggenheim Collection
  • Basilica S.Maria Gloriosa dei Frari
  • More

On day 11 of your exciting self-drive vacation in Italy, you’ll soak in the magnificence of 1 destination, including Venice. When you’re not sightseeing, take time to relax at your chosen hotel in Rome, where you’ll be staying for 1 night.

Visiting Rialto Bridge is always a good idea. This world-famous historical landmark is a place that is appreciated by travelers and locals alike. Next, immerse yourself in the awe-inspiring wonders of Palazzo Contarini Del Bovolo, a must-see palace in the city.

Consider stopping for a small bite to eat or a drink at a local eatery to keep your energy going. When you’re ready, continue your discovery with a visit to Campo Sant'angelo. This intriguing public square offers an enriching experience. For a change of pace, head to Peggy Guggenheim Collection, where you can take in visually striking features. Conclude your self-guided sightseeing tour with a visit to Santa Maria Gloriosa Dei Frari. These sights offer a fulfilling end to a perfect day.

After soaking up all the sights on today's itinerary, you'll be ready to head to your accommodation in Rome. Rome offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Rome. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Make sure to reserve a table at Hotel de Russie, an iconic dining spot in Rome. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of La Taverna Italiana, a popular restaurant in Rome. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of The Parrot Bar, a hidden gem nestled in Rome. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

Cap off your dinner by heading to The Apartment Bar Roma, ideal for a leisurely evening with a drink in hand. Hotel Hassler Roma is another bar that offers an enjoyable setting.

As the sun sets, rest up and recharge for the next leg of your road trip in Italy.

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Day 12

Day 12

  • Rome - Departure day
  • More
  • Pantheon
  • More

Day 12 of your road trip in Italy is your departure day. This is your chance to catch a last glimpse of Rome before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

If you're up for some more sightseeing, begin at Pantheon. This wondrous monument is a hotspot among locals.

Take advantage of your accommodation's proximity to Rome’s shopping district for some last-minute bargain hunting. Explore local shops for souvenirs to remember your trip or find unique gifts for loved ones.

Before you conclude your road trip in Italy, drop by another restaurant for a last chance at a memorable dining experience in Rome.

Enjoy a lovely meal at Sofitel Roma Villa Borghese, a top-rated place to have dinner tonight. Alternatively, if your taste buds call for something different, Centro is another top choice with a popular menu.

You’ll then say farewell to Rome. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Italy!

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Shortly after booking, you’ll receive your full itinerary, including schedules, locations, and everything you need for a stress-free trip.
Personalize your itinerary
Each package includes a professionally crafted itinerary you can tailor to your travel style. A dedicated travel expert will make sure every detail fits your needs perfectly.
Easily make changes
Need to update plans? No problem. Whether before your trip or mid-journey, we’re just seconds away to help with quick adjustments.
Enjoy seamless planning
With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.
Explore with confidence
From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.
Secure your spot
Confirm your package instantly and lock in the best rate with secure payment and guaranteed availability.
Get instant confirmation
Shortly after booking, you’ll receive your full itinerary, including schedules, locations, and everything you need for a stress-free trip.
Personalize your itinerary
Each package includes a professionally crafted itinerary you can tailor to your travel style. A dedicated travel expert will make sure every detail fits your needs perfectly.
Easily make changes
Need to update plans? No problem. Whether before your trip or mid-journey, we’re just seconds away to help with quick adjustments.
Enjoy seamless planning
With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.
Explore with confidence
From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.

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Your trip is protected, personalized, and priced right. No surprises, no stress.

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