12-Day Italy Self-Drive Road Trip With Itinerary from Trieste to Venice, Florence, Siena, Rome, and Santa Maria degli Angeli

Greet day 2 of your road trip in Italy with a smile and start your day with a hearty breakfast. You have 1 night to stay in Trieste, so get ready to make the most of your time in the region. On the agenda for this day, you’ll find only the best things to see and do in Miramare / Miramar and Trieste.

Make time for Miramare Castle, a popular castle that is worthwhile a visit in the village. Nearby, you’ll find Canale Ponterosso Trieste, enchanting visitors with its romantic appeal. Continue your exploration at Palazzo Gopcevich. This palace is one of the village’s most curiosity-inducing spots.

Enjoy the freedom of exploring Trieste at your own pace and find hidden gems along the way. If you want to see more picture-perfect spots, make sure to visit Molo Audace. After exploring the pier, head to the popular Piazza Unità D'italia. Lastly, wrap up today’s self-guided sightseeing tour with a visit to Cattedrale Di San Giusto Martire, a place of stunning interest in Trieste.

When you’re done exploring for the day, you’ll return to Trieste and your accommodation.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Trieste. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Treat yourself to a wonderful meal at Rustiko, a top-rated dining spot in Trieste. If you're in the mood for something new, try Caffè San Marco, another premier location with a delectable menu. You might also want to book a table at Osteria Marise. Known for its consistently satisfied patrons, it’s a perfect choice to elevate your evening in Trieste.

If you’re not ready to end the night just yet, Mast offers a perfect venue to relax and savor a drink. Similarly, Urbanis is well-suited for those looking to unwind in a social setting. Coktail Bar Trieste | La Preferita is another excellent spot to enjoy a nightcap after a delightful meal.

Raise your glass and celebrate another amazing day of your road trip in Italy!

Your itinerary for day 3 of your road trip in Italy includes 1 stop and features some of the highlights of Venice. At the end of the day, enjoy the comforts of a top-rated hotel in Venice, where you'll spend 2 nights.

Whatever your travel style is, Bridge Of Sighs is an essential stop in Trieste. This captivating monument provides an insightful glimpse into the city's identity. Next, discover Doge's Palace, a grand palace, promising a delightful encounter.

Continue your sightseeing with a visit to St Mark's Basilica, a notable church. When you’re done, don’t forget to make a stop at the iconic Piazza San Marco. Not far away from the public square, you will find the culturally significant Rialto Bridge, perfect for a quick visit. Round off your day at Palazzo Contarini Del Bovolo, another gem in Trieste with enchanting features to discover.

After soaking up all the sights on today's itinerary, you'll be ready to head to your accommodation in Venice. Venice offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

Indulge in a memorable dining experience at one of Venice's most popular restaurants, and connect with friendly locals for a true cultural experience.

Have a fantastic dining experience at Bauer Hotel, a highly recommended choice for tonight's dinner. If you're looking to mix things up, L'Osteria Le Guglie offers an enticing alternative with its varied menu. Additionally, Corner Pub is worth considering. Renowned for satisfying diners, it’s an ideal option for tonight in Venice.

Cap off your culinary experience with a visit to some of the most celebrated bars in the area. For instance, Al Parlamento stands out as an excellent choice for a post-dinner cocktail. Alternatively, The Caffe Rosso offers an ideal atmosphere to enjoy the pleasures of the night. Adagio is also a great option that provides a perfect setting for a relaxing evening.

Relax and look forward to more memorable moments to come!

On day 4 of your road trip in Italy, you’ll start and end your day in Venice, but spend the day exploring what’s beyond the city. Since you still have 1 night to spend in Venice, there’s no need to rush. Experience Murano and Venice to the fullest today with this curated day itinerary.

Whether you decide to explore Murano on foot, use public transport, or join a guided tour, there are a few attractions you don’t want to miss. Make sure to visit Cannaregio, a popular neighborhood in Murano. Spend some time wandering around the area and soak in its distinctive charm. You’ll also discover that several of the city’s must-see attractions are just around the corner.

Visiting Murano Lighthouse is always a good idea. This beloved lighthouse is a place that is appreciated by travelers and locals alike. Next, immerse yourself in the stunning wonders of Santa Maria Gloriosa Dei Frari, a must-see church in the village.

Consider stopping for a small bite to eat or a drink at a local eatery to keep your energy going. When you’re ready, continue your discovery with a visit to Gallerie Dell'accademia. This intriguing art gallery offers an enriching experience. For a change of pace, head to Peggy Guggenheim Collection, where you can take in enchanting features. Conclude your self-guided sightseeing tour with a visit to Santa Maria Della Salute. These sights offer a fulfilling end to a perfect day.

When you’re done exploring the area’s best attractions, you’ll drive back to your accommodation in Venice.

After a day of adventure, treat yourself to an exquisite dinner at one of Venice's best restaurants.

Enjoy a delicious meal at Generator Venice, a highly-rated dining destination in Venice. If you're eager to try something different, consider Nevodi, another top spot with a tantalizing menu. You might also want to secure a reservation at Ristorante La Piazza. With a reputation for consistently satisfying customers, it’s an excellent choice to enhance your stay in Venice this evening.

After savoring a delicious meal, step into the vibrant nightlife at Il Mercante, where the evening is just getting started. In the same way, The Irish Pub Venezia offers a unique charm perfect for experiencing the local bar scene in Venice. Ai Stagneri is another top-recommended bar that is sure to get you into the mood for some dancing and celebrating.

Say good night to Venice and look forward to another great day of your road trip in Italy!

On day 5 of your exciting self-drive vacation in Italy, you’ll soak in the magnificence of 1 destination, including Florence. When you’re not sightseeing, take time to relax at your chosen hotel in Florence, where you’ll be staying for 2 nights.

Let Pitti Palace set the tone for the day. Spend some time admiring this romantic palace before continuing your journey. Ponte Vecchio is your next stop. This world-famous historical landmark is one of the best-rated sights in Venice.

Consider grabbing some lunch or a light snack to keep your energy going. Beyond the above-mentioned attractions, today is also the perfect time to visit Uffizi Gallery. This picture-perfect art gallery is a sight to behold. To round off your sightseeing experience, visit Fountain Of Neptune and Piazza Della Signoria.

At the end of the day, you will drive to Florence, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

After a day of adventure, treat yourself to an exquisite dinner at one of Florence's best restaurants.

Dine in style at Ristorante Oliviero 1962, a top recommendation for dinner tonight. Or, for a change of pace, Di Poneta Novoli boasts a menu that's sure to impress. Also, be sure to check out Caffe San Firenze. Known as a local hotspot, it’s a great choice for tonight in Florence.

After your meal, keep the night alive at a bar like Manifattura, known for its lively atmosphere. Se·sto On Arno Rooftop Bar is another top recommendation that provides the perfect setting with well-crafted drinks and a welcoming ambiance. Similarly, Il Vinile offers an excellent atmosphere for those looking to amp up the evening.

Celebrate another amazing day of your road trip adventure in Italy!

Day 6 offers an itinerary packed with the best things to see in Florence. You’ll stay in Florence for 1 night more, offering you enough time to explore at a relaxed pace.

Whether you decide to explore Florence on foot, use public transport, or join a guided tour, there are a few attractions you don’t want to miss.

Your adventure in Florence is only getting started when you visit Piazzale Michelangelo, a famous local hot spot. Another notable attraction to explore is Basilica Of Santa Croce In Florence. This well-known church is known for its romantic appeal.

After soaking in the highlights of these sights, take some time to wander Florence's streets and immerse yourself in the local atmosphere. When you're ready to continue your sightseeing adventure, head to Cathedral Of Santa Maria Del Fiore. This UNESCO world heritage-designated church offers a fascinating experience that many visitors find memorable. Central Market is also worth visiting, along with Galleria Dell'accademia. These standout landmarks offer unique experiences that add to the day’s enjoyment. End your day at David. This popular statue provides a fitting finale to your sightseeing.

Don’t forget to check out all the popular tours and experiences you can add to your travel plans in Italy. You can explore and select activities under each day of your itinerary.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Florence. Enjoy a relaxing evening as you savor delicious local cuisine.

Dine in style at Ditta Artigianale, a top recommendation for dinner tonight. Or, for a change of pace, Trattoria Da Burde boasts a menu that's sure to impress. Also, be sure to check out Casa Toscana. Known as a local hotspot, it’s a great choice for tonight in Florence.

Cap off your culinary experience with a visit to some of the most celebrated bars in the area. For instance, Bar 50 Rosso stands out as an excellent choice for a post-dinner cocktail. Alternatively, Bitter Bar offers an ideal atmosphere to enjoy the pleasures of the night. Archea Brewery is also a great option that provides a perfect setting for a relaxing evening.

Relax and look forward to more memorable moments to come!

Dive into day 7 of your remarkable road trip in Italy. Today you'll explore 1 destination, including Siena. At the end of the day, you’ll unwind at one of the finest accommodations in Siena, where you'll spend 1 night.

Make time for Fortezza Medicea (siena), a curiosity-inducing monument that is worthwhile a visit in the city. Nearby, you’ll find Basilica Of San Domenico, enchanting visitors with its stunning appeal. Continue your exploration at Siena Cathedral. This church is one of the city’s most interesting spots.

Enjoy the freedom of exploring Florence at your own pace and find hidden gems along the way. If you want to see more picture-perfect spots, make sure to visit Piazza Del Campo. After exploring the public square, head to the up-and-coming Pubblico Palace. Lastly, wrap up today’s self-guided sightseeing tour with a visit to Porta Pispini, a place of breathtaking interest in Florence.

When you’re done exploring for the day, you’ll drive to your hotel in Siena. Check in and relax before you head out to tour the city.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Siena, it's often a good idea to reserve a table in advance.

Treat yourself to a delightful dinner at Enoteca I Terzi, highly recommended for tonight's dining. Or, if you're feeling adventurous, why not try Ristorante Tar-Tufo? It's another excellent option with a diverse menu. Consider reserving a table at Antica Trattoria Papei as well. Known for its consistent customer satisfaction, it’s an ideal pick for tonight in Siena.

Keep the evening going at Meet Life Cafè, a great choice for enjoying the after-dinner hours with a drink. You could also go to Maudit Pub, which offers a similarly pleasant setting and great drinks. Another option is Bar Impero Siena, which provides an inviting environment for unwinding after a busy day out.

Raise your glass to another unforgettable day in Italy!

On day 8 of your road trip in Italy, your travel plans include 1 stop at the most scenic, wondrous, and interesting places in the region. Rome are on today's agenda. In the evening, you’ll end up in Rome, where you will stay for 2 nights.

Experience Colosseum, a timeless archeological site in the city. Then, head to Roman Forum and soak in the ambiance of this picture-perfect archeological site.

There are many interesting places to see in Siena, and when you are ready for more, go to Spanish Steps. This is one of the city’s most widely recognized enchanting spots of interest. After exploring the public square, visit the wondrous Piazza Di Spagna. Not far away, you'll also find Trevi Fountain. This monument is an enchanting highlight in Siena.

After soaking up all the sights on today's itinerary, you'll be ready to head to your accommodation in Rome. Rome offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Rome. Enjoy a relaxing evening as you savor delicious local cuisine.

Enjoy a delicious meal at La Bottega Roma, a top-rated dining destination in Rome. If you're in the mood to try something new, consider Pasta In Corso, another top spot with a mouthwatering menu. You might also want to secure a reservation at Trattoria Vecchia Roma. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Rome this evening.

After your delicious meal, get a taste of the vibrant nightlife with a visit to La Botticella Of Poggi Giovanni, known for its inviting atmosphere. Almalu Trastevere is another great option if you’re looking for a place to get the night started. Similarly, Bar Viminale Di Pepi Maurilio provides a great setting to enjoy the night away.

Relax and recharge in preparation for another adventurous day in Italy!

Wake up to day 9 of your road trip in Italy. On this day, you’ll embark on an exciting expedition discovering the enchanting sights and activities of Vatican City and Rome. With 1 night to stay in Rome, we encourage you to seize the day and discover the unexplored beauty of the city’s surroundings!

A top thing to do today is to explore Trastevere, a must-see neighborhood in Vatican City. It's the perfect starting point for touring the top attractions in the area.

Catch Vatican Museums before the crowds roll in.

In between sights, stop by local stores, picturesque photo spots, and small eateries. When you’re ready for your next attraction, proceed to St. Peter's Basilica, a globally renowned major basilica. For a change of scene, check out Pantheon, known for its culturally significant features. We also recommend visiting Piazza Navona. This public square is a must for anyone looking to experience the city to the fullest.

When you’re done exploring for the day, you’ll return to Rome and your accommodation.

Rome is a place where the culinary landscape is as diverse as its attractions. So before the day ends, treat your palate to a taste of local cuisine at one of the best restaurants in Rome.

Make sure to reserve a table at RomAntica, an iconic dining spot in Rome. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Coso Ristorante, a popular restaurant in Rome. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of DEROMA - Farine Romane, a hidden gem nestled in Rome. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

To truly maximize your evening out, consider visiting Sant' Eustachio Caffè after dinner. This bar is known for offering some of the best drinks and vibes in the city. Alternatively, head to Yellowsquare Rome, another bar with an inviting ambiance. Similarly, Caffè Portofino also offers a great atmosphere, ensuring a night filled with enjoyment and relaxation.

Get a good night's sleep and look forward to another great day on the road in Italy!

Experience an unparalleled adventure on day 10 of your road trip in Italy. This exciting part of your journey invites you to discover the renowned landmarks in 2 places, which are Santa Maria degli Angeli and Valecchie. At the end of the day, you will retreat to the hotel of your choice in Santa Maria degli Angeli, where will spend 1 night.

Start your day at Mount Subasio. This romantic mountain range is a beloved place to see in Rome. Then, wander over to Pinacoteca Comunale Palazzo Vallemani. If photogenic sites excite you, this art gallery will be right up your alley. Nearby, you’ll also find Basilica Of San Francesco D'assisi. This stunning church is a favorite among visitors.

Rome offers plenty to explore, ensuring every moment of your visit is filled with excitement and discovery. If you're up for more, Chiesa Di San Pietro is an intriguing spot in the town that will captivate you with its unique charm. When you’re done at the church, don’t forget to check out the majestic Piazza Del Comune. Take a moment to appreciate the fascinating details of this worthwhile public square.

At the end of the day, you will drive to Santa Maria degli Angeli, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

Santa Maria degli Angeli is a place where the culinary landscape is as diverse as its attractions. So before the day ends, treat your palate to a taste of local cuisine at one of the best restaurants in Santa Maria degli Angeli.

Known for great service, it’s a fantastic choice for tonight in Santa Maria degli Angeli.

To truly maximize your evening out, consider visiting Bibenda Assisi Wine Tasting & Gourmet Food, Olive Oil And Chocolate Tastings after dinner. This bar is known for offering some of the best drinks and vibes in the city.

Head back to your accommodation in Santa Maria degli Angeli and get some rest to prepare for another magical day of your road trip in Italy.

Your itinerary for day 11 of your road trip in Italy includes 1 stop and features some of the highlights of Bologna. At the end of the day, enjoy the comforts of a top-rated hotel in Trieste, where you'll spend 1 night.

Catch Fountain Of Neptune, Bologna before the crowds roll in. This noteworthy monument is sure to ignite your curiosity. Next, dive into the history-steeped features of Piazza Maggiore, a must-visit public square in the city.

In between sights, stop by local stores, picturesque photo spots, and small eateries. When you’re ready for your next attraction, proceed to Piazza Santo Stefano, an underrated public square. For a change of scene, check out Two Towers, known for its instagrammable features. We also recommend visiting San Martino. This church is a must for anyone looking to experience the city to the fullest.

When you’re done exploring for the day, you’ll drive to your hotel in Trieste. Check in and relax before you head out to tour the city.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Trieste. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Treat yourself to a wonderful meal at Caffè degli Specchi, a top-rated dining spot in Trieste. If you're in the mood for something new, try Osteria Istriano Of Giobi And Oxa, another premier location with a delectable menu. You might also want to book a table at Chimera di Bacco. Known for its consistently satisfied patrons, it’s a perfect choice to elevate your evening in Trieste.

Cap off your dinner by heading to "life" New Bar Torinese Snc, ideal for a leisurely evening with a drink in hand. White Cafe is another bar that offers an enjoyable setting. Similarly, Café James Joyce is also a popular place to go on a night out, perfect for relaxing and socializing.

As the day draws to a close, take a moment to unwind and prepare for the next exciting chapter of your road trip in Italy.