12-Day Italy Self-Drive Road Trip With Itinerary from Trieste to Venice, Florence, Siena, Rome, and Santa Maria degli Angeli

Wake up to day 2 of your road trip in Italy. On this day, you’ll embark on an exciting expedition discovering the enchanting sights and activities of Miramare / Miramar and Trieste. With 1 night to stay in Trieste, we encourage you to seize the day and discover the unexplored beauty of the city’s surroundings!

Whether you decide to explore Miramare / Miramar on foot, use public transport, or join a guided tour, there are a few attractions you don’t want to miss.

No visit to Trieste is complete without Miramare Castle. This well-known castle is one of the top attractions in the village. Proceed to Canale Ponterosso Trieste, another must-visit attraction.

As you wander through the inviting streets of Trieste, soak in the lively ambiance and take the opportunity to snap some photos. Next, head to Palazzo Gopcevich. This underrated palace is a traveler-favorite. Not far away, you’ll find Molo Audace, another key site on your sightseeing itinerary. Piazza Unità D'italia is yet another highly recommended place to visit nearby, offering plenty to discover for curious travelers. Conclude your day at Cattedrale Di San Giusto Martire and uncover why it's recognized as one of the village's most intriguing attractions.

When you’re done exploring the area’s best attractions, you’ll drive back to your accommodation in Trieste.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Trieste. Enjoy a relaxing evening as you savor delicious local cuisine.

Savor the flavors at Rustiko, a top pick for dinner tonight. Alternatively, Caffè San Marco beckons with its unique menu offerings. Also, consider Osteria Marise. With its consistent customer satisfaction, it’s an excellent option for dining in Trieste tonight.

After enjoying a delightful dinner, why not delve into the vibrant local bar scene? You might want to spend the evening at Mast, a well-loved spot among locals and tourists. Or, head to Urbanis. This bar boasts a welcoming environment that is perfect for winding down. You could also continue your night at Coktail Bar Trieste | La Preferita, another top-rated place in the area.

Celebrate another amazing day of your road trip adventure in Italy!

On day 3 of your exciting self-drive vacation in Italy, you’ll soak in the magnificence of 1 destination, including Venice. When you’re not sightseeing, take time to relax at your chosen hotel in Venice, where you’ll be staying for 2 nights.

Bridge Of Sighs makes a great addition to your morning plans. This captivating monument is a symbolic place to see in Trieste. Continue your discovery at Doge's Palace, an enchanting palace with stories to tell.

As you stroll around Trieste, take in the distinct atmosphere and learn what makes this city so unique. Maximize your sightseeing with a visit to St Mark's Basilica. This popular church offers an enchanting encounter with Trieste. Next, make your way to Piazza San Marco to add another highlight to your day. After that, visit Palazzo Contarini Del Bovolo, a notable palace that’s sure to impress. If you’re up for more, end your self-guided sightseeing tour at Rialto Bridge, a wondrous historical landmark in the city. Whether you decide to get entrance tickets for all attractions or you prefer admiring from a distance, amazing experiences await on this day in Trieste.

When you’re done exploring for the day, you’ll drive to your hotel in Venice. Check in and relax before you head out to tour the city.

After a day of adventure, treat yourself to an exquisite dinner at one of Venice's best restaurants.

Make sure to reserve a table at Bauer Hotel, an iconic dining spot in Venice. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of L'Osteria Le Guglie, a popular restaurant in Venice. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of Corner Pub, a hidden gem nestled in Venice. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

To truly maximize your evening out, consider visiting Al Parlamento after dinner. This bar is known for offering some of the best drinks and vibes in the city. Alternatively, head to The Caffe Rosso, another bar with an inviting ambiance. Similarly, Adagio also offers a great atmosphere, ensuring a night filled with enjoyment and relaxation.

Relax and recharge in preparation for another adventurous day in Italy!

On day 4 of your road trip, you’ll start and end your day in Venice, where you still have 1 night left. You'll spend part of the day exploring places of interest outside the immediate city, including Murano and Venice.

Cannaregio is a fantastic place you can explore today in Murano. This neighborhood is a testament to the city’s character, and it's easy to spend hours just walking around and admiring the surroundings. Soak in the Murano-way-of-life and visit all the nearby sights.

Catch Murano Lighthouse before the crowds roll in. This instagrammable lighthouse is sure to ignite your curiosity. Next, dive into the awe-inspiring features of Santa Maria Gloriosa Dei Frari, a must-visit church in the village.

In between sights, stop by local stores, picturesque photo spots, and small eateries. When you’re ready for your next attraction, proceed to Gallerie Dell'accademia, an underrated art gallery. For a change of scene, check out Peggy Guggenheim Collection, known for its noteworthy features. We also recommend visiting Santa Maria Della Salute. This church is a must for anyone looking to experience the village to the fullest.

When you’re done exploring for the day, you’ll return to Venice and your accommodation.

After a day of adventure, treat yourself to an exquisite dinner at one of Venice's best restaurants.

Treat yourself to a wonderful meal at Generator Venice, a top-rated dining spot in Venice. If you're in the mood for something new, try Nevodi, another premier location with a delectable menu. You might also want to book a table at Ristorante La Piazza. Known for its consistently satisfied patrons, it’s a perfect choice to elevate your evening in Venice.

Following your dinner, dive into the local bar culture at Il Mercante. Enjoy this evening's relaxed ambiance with delightful drinks. Alternatively, go to The Irish Pub Venezia, the perfect place for those looking to experience the best of the nightlife. Similarly, Ai Stagneri provides excellent drinks and a great atmosphere, ensuring a memorable night out.

Get a good night's sleep and look forward to another great day on the road in Italy!

On day 5 of your road trip in Italy, your travel plans include 1 stop at the most scenic, wondrous, and interesting places in the region. Florence are on today's agenda. In the evening, you’ll end up in Florence, where you will stay for 2 nights.

Your adventure in Venice is only getting started when you visit Pitti Palace, a locally renowned local hot spot. Another notable attraction to explore is Ponte Vecchio. This iconic historical landmark is known for its visually striking appeal.

After soaking in the highlights of these sights, take some time to wander Venice's streets and immerse yourself in the local atmosphere. When you're ready to continue your sightseeing adventure, head to Uffizi Gallery. This eye-catching art gallery offers a fascinating experience that many visitors find memorable. Fountain Of Neptune is also worth visiting, along with Piazza Della Signoria. These standout landmarks offer unique experiences that add to the day’s enjoyment.

At the end of the day, you will drive to Florence, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Florence. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Make sure to reserve a table at Ristorante Oliviero 1962, an iconic dining spot in Florence. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Di Poneta Novoli, a popular restaurant in Florence. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of Caffe San Firenze, a hidden gem nestled in Florence. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

After your meal, keep the night alive at a bar like Manifattura, known for its lively atmosphere. Se·sto On Arno Rooftop Bar is another top recommendation that provides the perfect setting with well-crafted drinks and a welcoming ambiance. Similarly, Il Vinile offers an excellent atmosphere for those looking to amp up the evening.

Raise your glass to another unforgettable day in Italy!

On day 6 of your road trip, you will have an entire day to discover what to see in Florence. You’ll stay in Florence for 1 night.

Experience Piazzale Michelangelo, a famous observation deck in the city. Then, head to Basilica Of Santa Croce In Florence and soak in the ambiance of this culturally significant church.

There are many interesting places to see in Florence, and when you are ready for more, go to Cathedral Of Santa Maria Del Fiore. This is one of the city’s most astonishing history-steeped spots of interest. After exploring the church, visit the well-known Central Market. Not far away, you'll also find Galleria Dell'accademia. This art gallery is a detailed highlight in Florence. Before wrapping up your self-guided sightseeing tour, head to David, a well-known statue in the city.

Don’t forget to check out all the popular tours and experiences you can add to your travel plans in Italy. You can explore and select activities under each day of your itinerary.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Florence, it's often a good idea to reserve a table in advance.

Treat yourself to a wonderful meal at Ditta Artigianale, a top-rated dining spot in Florence. If you're in the mood for something new, try Trattoria Da Burde, another premier location with a delectable menu. You might also want to book a table at Casa Toscana. Known for its consistently satisfied patrons, it’s a perfect choice to elevate your evening in Florence.

Unwind after your meal by stepping into Bar 50 Rosso. This venue is celebrated for its extensive drink selections and cozy vibes. Alternatively, Bitter Bar offers a dynamic and energetic atmosphere for a glass or two. Don’t overlook Archea Brewery, another top-rated bar in the area.

As the day draws to a close, take a moment to unwind and prepare for the next exciting chapter of your road trip in Italy.

Dive into day 7 of your remarkable road trip in Italy. Today you'll explore 1 destination, including Siena. At the end of the day, you’ll unwind at one of the finest accommodations in Siena, where you'll spend 1 night.

Fortezza Medicea (siena) is perfect for a self-paced visit during the day. This breathtaking monument is sure to impress. Next on your list is Basilica Of San Domenico, another must-visit landmark and curiosity-inducing church renowned for its stunning features.

While exploring and sightseeing, take time to savor the culture of Florence by sampling some local delicacies. When you’re ready for more sightseeing, head to Siena Cathedral. This enchanting church is an essential place to visit for anyone looking for the full Florence experience. We also recommend visiting Piazza Del Campo, an impressive public square. Nearby, you'll also find Pubblico Palace, ready to add charm to your journey. End your self-guided sightseeing tour with a stop at Porta Pispini and wrap up your day with its picture-perfect appeal.

After soaking up all the sights on today's itinerary, you'll be ready to head to your accommodation in Siena. Siena offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Siena, it's often a good idea to reserve a table in advance.

Treat yourself to a wonderful meal at Enoteca I Terzi, a top-rated dining spot in Siena. If you're in the mood for something new, try Ristorante Tar-Tufo, another premier location with a delectable menu. You might also want to book a table at Antica Trattoria Papei. Known for its consistently satisfied patrons, it’s a perfect choice to elevate your evening in Siena.

After enjoying a fulfilling meal, continue your evening at Meet Life Cafè, ideal for those looking to unwind with a drink in a comfortable setting. Alternatively, Maudit Pub offers a welcoming atmosphere for easing into the nightlife. Similarly, Bar Impero Siena provides an excellent environment for a relaxed and enjoyable evening.

Celebrate another amazing day of your road trip adventure in Italy!

Your itinerary for day 8 of your road trip in Italy includes 1 stop and features some of the highlights of Rome. At the end of the day, enjoy the comforts of a top-rated hotel in Rome, where you'll spend 2 nights.

One of the most globally renowned attractions included on the itinerary is Colosseum. This picture-perfect archeological site will help you start your sightseeing on top. Then, take a leisurely stroll to Roman Forum and learn what makes this culturally significant archeological site unique.

Throughout the day, make sure to take breaks to appreciate the surroundings. Next up, visit the extraordinary Spanish Steps. After exploring the public square, head to Piazza Di Spagna. This iconic public square is a highlight in Siena. As your day continues, stop by Trevi Fountain, known for its romantic features.

When you’re done exploring for the day, you’ll drive to your hotel in Rome. Check in and relax before you head out to tour the city.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Rome. Enjoy a relaxing evening as you savor delicious local cuisine.

Have a fantastic dining experience at La Bottega Roma, a highly recommended choice for tonight's dinner. If you're looking to mix things up, Pasta In Corso offers an enticing alternative with its varied menu. Additionally, Trattoria Vecchia Roma is worth considering. Renowned for satisfying diners, it’s an ideal option for tonight in Rome.

Keep the excitement of the evening going by visiting a bar or two. La Botticella Of Poggi Giovanni is an excellent place to start. You could also check out Almalu Trastevere, offering a different kind of charm. A last recommendation for the day is Bar Viminale Di Pepi Maurilio. This bar promises an enjoyable experience with tasty drinks and a vibrant setting.

Head back to your accommodation in Rome and get some rest to prepare for another magical day of your road trip in Italy.

On day 9 of your road trip, you’ll start and end your day in Rome, where you have 1 night left to stay.

Set aside time today to explore Trastevere, a standout neighborhood that reflects the essence of the city. While you're there, you'll also be within reach of some of the city's top landmarks, making it easy to maximize your day.

Let Vatican Museums set the tone for the day. Sistine Chapel is your next stop. This widely recognized chapel is one of the best-rated sights in Rome.

Consider grabbing some lunch or a light snack to keep your energy going. Beyond the above-mentioned attractions, today is also the perfect time to visit St. Peter's Basilica. To round off your sightseeing experience, visit Pantheon and Piazza Navona.

When you’re done exploring the area’s best attractions, you’ll drive back to your accommodation in Rome.

Rome is a place where the culinary landscape is as diverse as its attractions. So before the day ends, treat your palate to a taste of local cuisine at one of the best restaurants in Rome.

Enjoy a delicious meal at RomAntica, a highly-rated dining destination in Rome. If you're eager to try something different, consider Coso Ristorante, another top spot with a tantalizing menu. You might also want to secure a reservation at DEROMA - Farine Romane. With a reputation for consistently satisfying customers, it’s an excellent choice to enhance your stay in Rome this evening.

After your meal, keep the night alive at a bar like Sant' Eustachio Caffè, known for its lively atmosphere. Yellowsquare Rome is another top recommendation that provides the perfect setting with well-crafted drinks and a welcoming ambiance. Similarly, Caffè Portofino offers an excellent atmosphere for those looking to amp up the evening.

Relax and look forward to more memorable moments to come!

Experience an unparalleled adventure on day 10 of your road trip in Italy. This exciting part of your journey invites you to discover the renowned landmarks in 2 places, which are Santa Maria degli Angeli and Valecchie. At the end of the day, you will retreat to the hotel of your choice in Santa Maria degli Angeli, where will spend 1 night.

Mount Subasio brings Rome's character to life. This peaceful mountain range is a highlight of any visit in the town. Then, enjoy Pinacoteca Comunale Palazzo Vallemani, another history-steeped attraction that never fails to captivate visitors. Next, head over to Basilica Of San Francesco D'assisi, one of the town’s most notable attractions, known for its stunning features.

If you’re looking for more, spend time soaking in the atmosphere of Chiesa Di San Pietro. This culturally significant church is frequented by locals and tourists alike. To complete your memorable day, make sure to visit Piazza Del Comune, a locally appreciated public square, and take a stroll around the area.

At the end of the day, you will drive to Santa Maria degli Angeli, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

Indulge in a memorable dining experience at one of Santa Maria degli Angeli's most popular restaurants, and connect with friendly locals for a true cultural experience.

After your delicious meal, get a taste of the vibrant nightlife with a visit to Bibenda Assisi Wine Tasting & Gourmet Food, Olive Oil And Chocolate Tastings, known for its inviting atmosphere.

Say good night to Santa Maria degli Angeli and look forward to another great day of your road trip in Italy!

On day 11 of your exciting self-drive vacation in Italy, you’ll soak in the magnificence of 1 destination, including Bologna. When you’re not sightseeing, take time to relax at your chosen hotel in Trieste, where you’ll be staying for 1 night.

Check out the frequently visited monument, Fountain Of Neptune, Bologna. Afterward, continue to Piazza Maggiore, a public square every traveler should visit. As you explore Santa Maria degli Angeli’s charming streets, take in the lively atmosphere and get to know the character of the city.

Next, make your way to Piazza Santo Stefano. This up-and-coming public square is an essential stop. Following that, head to Two Towers, another must-visit site that will enhance your experience. Don’t forget to stop by San Martino, an increasingly popular church in the city.

After soaking up all the sights on today's itinerary, you'll be ready to head to your accommodation in Trieste. Trieste offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

Trieste is a place where the culinary landscape is as diverse as its attractions. So before the day ends, treat your palate to a taste of local cuisine at one of the best restaurants in Trieste.

Savor the flavors at Caffè degli Specchi, a top pick for dinner tonight. Alternatively, Osteria Istriano Of Giobi And Oxa beckons with its unique menu offerings. Also, consider Chimera di Bacco. With its consistent customer satisfaction, it’s an excellent option for dining in Trieste tonight.

After enjoying a delightful dinner, why not delve into the vibrant local bar scene? You might want to spend the evening at "life" New Bar Torinese Snc, a well-loved spot among locals and tourists. Or, head to White Cafe. This bar boasts a welcoming environment that is perfect for winding down. You could also continue your night at Café James Joyce, another top-rated place in the area.

Relax and look forward to more memorable moments to come!