13-Day Italy Self-Drive Road Trip With Itinerary from Genoa traveling east to Florence, Rome, and Siena

On day 2 of your road trip in Italy, you’ll start and end your day in Genoa, but spend the day exploring what’s beyond the city. Since you will return to Genoa for 2 nights more, there’s no need to rush. Experience Genoa and San Fruttuoso di Camogli to the fullest today with this curated day itinerary!

Genoa is home to plenty of attractions that offer family-friendly attractions, breathtaking views, and photo-friendly spots! Start at Porta Soprana, an increasingly popular monument that is worthwhile a visit in the city. Nearby, you’ll find Piazza De Ferrari, enchanting visitors with its symbolic appeal. Continue your exploration at Genoa Cathedral. This church is one of the city’s most frequently visited spots.

Enjoy the freedom of exploring Genoa at your own pace and find hidden gems along the way. If you want to see more picture-perfect spots, make sure to visit Via Garibaldi. After exploring the street, head to the worthwhile Palazzo Podestà. Lastly, wrap up today’s self-guided sightseeing tour with a visit to Area Marina Protetta Di Portofino, a place of awe-inspiring interest in Genoa.

When you’re done exploring for the day, you’ll return to Genoa and your accommodation.

Indulge in a memorable dining experience at one of Genoa's most popular restaurants, and connect with friendly locals for an authentic adventure.

Treat yourself to a wonderful meal at Zeffirino, a top-rated dining spot in Genoa. If you're in the mood for something new, try Trattoria Vegia Zena, another premier location with a delectable menu. You might also want to book a table at Trattoria delle Grazie. Known for its consistently satisfied patrons, it’s a perfect choice to elevate your evening in Genoa.

Get a good night's sleep and look forward to another great day on the road in Italy!

Wake up to day 3 of your extraordinary road trip in Italy. With 1 night left in Genoa, we encourage you to seize the day and discover the unexplored beauty of the city’s surroundings!

Start your adventure at Riomaggiore. This increasingly popular sightseeing destination is a must-visit for travelers looking for a unique holiday experience. Make your way to Chiesa Di San Lorenzo located in Genoa for another exciting encounter.

Next, immerse yourself in the setting of Manarola Overlook Viewpoint. Its romantic features will captivate you. After the observation deck, continue your tour of the village with a visit to Cinque Terre National Park. Visitors usually appreciate the romantic features of this national park.

When you’re done exploring the area’s best attractions, you’ll drive back to your accommodation in Genoa.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Genoa. Enjoy a relaxing evening as you savor delicious local cuisine and reflect on the day's adventures.

Enjoy a lovely dining experience at Osteria Sant'Ilario, a popular restaurant in Genoa. This acclaimed establishment has earned the admiration of countless food lovers in the city. Alternatively, experience a taste of Genoa at La Cialtroneria, another great place to eat. With a menu designed to impress, it promises a journey of flavors that will leave you captivated. A third option to check out is the top-rated Manhattan Bar. It’s yet another ideal choice to enhance your time in Genoa tonight.

Relax and reminisce about your day in Italy and look forward to more memorable moments to come!

On day 4 of your road trip in Italy, you will get a true taste of the freedom a self-drive vacation in Europe entails. Today’s travel plans include stops at the most scenic, wondrous, and interesting places in Florence. In the evening, you’ll end up in Florence, where you will stay for 3 nights.

Today’s itinerary in Genoa covers several incredible sights, including a historical landmark, an art gallery, a palace, a public square and much more! Start your adventure at Ponte Vecchio. This wondrous historical landmark is a place that is appreciated by travelers and locals alike. Next, immerse yourself in the romantic wonders of Uffizi Gallery, a must-see art gallery in the city.

Consider stopping for a small bite to eat or a drink at a local eatery to keep your energy going. When you’re ready, continue your discovery with a visit to Palazzo Vecchio. This locally renowned palace offers an enriching experience. For a change of pace, head to Loggia Dei Lanzi, where you can take in history-steeped features. Conclude your self-guided sightseeing tour with a visit to Piazza Della Signoria. These sights offer a fulfilling end to a perfect day.

At the end of the day, you will drive to Florence, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

After a day of adventure, treat yourself to an exquisite dinner at one of Florence's best restaurants.

Treat yourself to a delightful dinner at Ristorante Oliviero 1962, highly recommended for tonight's dining. Or, if you're feeling adventurous, why not try Di Poneta Novoli? It's another excellent option with a diverse menu. Consider reserving a table at Caffe San Firenze as well. Known for its consistent customer satisfaction, it’s an ideal pick for tonight in Florence.

Explore the vibrant nightlife at Manifattura after your meal, a hub for lively evenings and memorable moments. Or, head to Se·sto On Arno Rooftop Bar for a great selection of flavorful drinks and a charming setting. Furthermore, Il Vinile is perfect for those looking to extend their night with a touch of local flavor.

Celebrate another amazing day of your road trip adventure in Italy!

Day 5 offers a multitude of experiences. You will stay in Florence for 2 nights more, offering you enough time to explore at a relaxed pace.

Start your day with a visit to David. This well-known statue is a must-visit in the city. When you’re ready for your next discovery, continue to Galleria Dell'accademia, which may be one of the most noteworthy places you will experience today.

One of the best things about exploring Florence on a self-guided tour is that you set the pace. There’s plenty of time for detours and discovering hidden gems. When you’re ready for your next stop, make your way to Medici Chapels, an up-and-coming museum in the city. If you’re up for more discoveries, don’t forget to reserve some time for Cathedral Of Santa Maria Del Fiore and Basilica Of Santa Croce In Florence. End your day with a visit to Piazzale Michelangelo, a famous observation deck that’s sure to leave a lasting impression.

Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.

Indulge in a memorable dining experience at one of Florence's most popular restaurants, and connect with friendly locals for an authentic adventure.

Have a fantastic dining experience at Ditta Artigianale, a highly recommended choice for tonight's dinner. If you're looking to mix things up, Trattoria Da Burde offers an enticing alternative with its varied menu. Additionally, Casa Toscana is worth considering. Renowned for satisfying diners, it’s an ideal option for tonight in Florence.

Cap off your culinary experience with a visit to some of the most celebrated bars in the area. For instance, Bar 50 Rosso stands out as an excellent choice for a post-dinner cocktail. Alternatively, Bitter Bar offers an ideal atmosphere to enjoy the pleasures of the night. Archea Brewery is also a great option that provides a perfect setting for a relaxing evening.

Raise your glass to another unforgettable day in Italy!

Greet day 6 of your road trip in Italy with a smile and start your day with a hearty breakfast. You will return to Florence for your remaining 1 night in the city later today, but first, it’s time for some exploring! On the agenda for this day, you’ll find only the best things to see and do in Siena.

Bring your curiosity for today’s adventure around Florence. Some of the city’s most loved attractions await! Piazza Del Duomo is the perfect place to start. This public square is one of the most underrated places to visit in Florence. Next, head to Siena Cathedral, a captivating church, known for its inviting features.

In between the sights, don’t hesitate to take small detours to explore local stores and eateries. When you’re ready to continue your adventure, head to Piazza Del Campo. This UNESCO world heritage-listed public square is a highly recommended experience. Nearby, you'll also find Tower Of Mangia and Loggia Del Papa, Siena. Visit these for an interesting touch to your journey.

When you’re done exploring for the day, you’ll return to Florence and your accommodation.

As dinnertime approaches, it's time to head out for a bite to eat in Florence. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.

Make sure to reserve a table at Ristorante Buca Mario, an iconic dining spot in Florence. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Agricola Toscana, a popular restaurant in Florence. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of Eataly Firenze, a hidden gem nestled in Florence. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

Cap off your dinner by heading to Gosh*, ideal for a leisurely evening with a drink in hand. Antico Caffè Del Moro - Art Bar Firenze is another bar that offers an enjoyable setting. Similarly, Quelo Bar is also a popular place to go on a night out, perfect for relaxing and socializing.

As the sun sets on another day of adventure, rest up and recharge for the next leg of your road trip in Italy.

Dive into day 7 of your remarkable road trip in Italy. Today you will explore Rome, where you will have the opportunity to experience all the top things to see and do. At the end of the day, you’ll unwind at one of the finest accommodations in Rome. You’ll stay here for 4 nights.

Whether you prefer a leisurely exploration or a more fast-paced adventure, this itinerary in Florence allows for both. Start by heading to Castel Sant'angelo. This widely recognized castle provides an insightful glimpse into the city's identity. Next, discover Piazza Navona, a noteworthy public square, promising a delightful encounter.

Continue your sightseeing with a visit to Pantheon, a timeless monument. When you’re done, don’t forget to make a stop at the iconic Trevi Fountain. Not far away from the monument, you will find the culturally significant Circus Maximus, perfect for a quick visit. Round off your day at Piazza Del Popolo, another gem in Florence with enchanting features to discover.

After soaking up all the sights of today's itinerary, you'll be ready to head in the direction of your accommodation in Rome. Rome offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Rome. Enjoy a relaxing evening as you savor delicious local cuisine and reflect on the day's adventures.

Dine in style at La Bottega Roma, a top recommendation for dinner tonight. Or, for a change of pace, Pasta In Corso boasts a menu that's sure to impress. Also, be sure to check out Trattoria Vecchia Roma. Known as a local hotspot, it’s a great choice for tonight in Rome.

After enjoying a fulfilling meal, continue your evening at La Botticella Of Poggi Giovanni, ideal for those looking to unwind with a drink in a comfortable setting. Alternatively, Almalu Trastevere offers a welcoming atmosphere for easing into the nightlife. Similarly, Bar Viminale Di Pepi Maurilio provides an excellent environment for a relaxed and enjoyable evening.

Relax and reminisce about your day in Italy and look forward to more memorable moments to come!

On day 8 of your road trip, you will have an entire day to explore Rome. You’ll stay in Rome for 3 nights and discover all the best things to see and do in the area.

Today’s itinerary in Rome covers several incredible sights, including an archeological site, a monument, a public square, a park and much more! Start your adventure at Colosseum. This timeless archeological site is a place that is appreciated by travelers and locals alike. Next, immerse yourself in the culturally significant wonders of Arch Of Constantine, a must-see monument in the city.

Consider stopping for a small bite to eat or a drink at a local eatery to keep your energy going. When you’re ready, continue your discovery with a visit to Roman Forum. This wondrous archeological site offers an enriching experience. For a change of pace, head to Piazza Di Spagna, where you can take in grand features. Conclude your self-guided sightseeing tour with a visit to Spanish Steps and Villa Borghese. These sights offer a fulfilling end to a perfect day.

Don’t forget to check out all the popular tours and activities you can add to your road trip itinerary. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.

As dinnertime approaches, it's time to head out for a bite to eat in Rome. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.

Enjoy a delicious meal at RomAntica, a highly-rated dining destination in Rome. If you're eager to try something different, consider Coso Ristorante, another top spot with a tantalizing menu. You might also want to secure a reservation at DEROMA - Farine Romane. With a reputation for consistently satisfying customers, it’s an excellent choice to enhance your stay in Rome this evening.

After enjoying a delightful dinner, why not delve into the vibrant local bar scene? You might want to spend the evening at Sant' Eustachio Caffè, a well-loved spot among locals and tourists. Or, head to Yellowsquare Rome. This bar boasts a welcoming environment that is perfect for winding down. You could also continue your night at Caffè Portofino, another top-rated place in the area.

Celebrate another amazing day of your road trip adventure in Italy!

On day 9 of your road trip, you’ll start and end your day in Rome, where you'll stay for 2 nights more.

Trastevere is one of the highlights of today. Take your time exploring this iconic neighborhood in Vatican City, which offers a perfect blend of history and culture. Plus, it's close to many must-see landmarks in the city. Be sure to also visit Monti, a neighborhood that showcases another side of Vatican City.

Enjoy the perfect balance of relaxation and exploration in Rome today. One of the most iconic attractions included on the itinerary is Vatican Museums.

Throughout the day, make sure to take breaks to appreciate the surroundings. Next up, visit the iconic St. Peter's Basilica.

When you’re done exploring the area’s best attractions, you’ll drive back to your accommodation in Rome.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Rome. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Enjoy a delicious meal at Hotel de Russie, a highly-rated dining destination in Rome. If you're eager to try something different, consider La Taverna Italiana, another top spot with a tantalizing menu. You might also want to secure a reservation at The Parrot Bar. With a reputation for consistently satisfying customers, it’s an excellent choice to enhance your stay in Rome this evening.

Keep the excitement of the evening going by visiting a bar or two. The Apartment Bar Roma is an excellent place to start. You could also check out Hotel Hassler Roma, offering a different kind of charm.

Savor another day of unforgettable experiences in Italy!

At the end of the day, you'll drive back to Rome, where you'll stay for 1 night more.

Get ready for an exciting day in Rome. Today’s sightseeing agenda includes a public square and an archeological site. Begin your adventure at Piazza Del Plebiscito. This is a top-rated public square you should not miss. Another must-see is Temple Of Venus, an often recommended archeological site in Rome.

When you’re ready for the next sight, head to Archaeological Park Of Pompeii.

When you’re done exploring for the day, you’ll return to Rome and your accommodation.

As you explore more of Rome, you'll discover that its culinary landscape is as diverse as its attractions. Whether you're craving traditional dishes bursting with local flavors or innovative creations that push the boundaries of taste, you're sure to find a dining experience that satisfies your cravings.

Dine in style at Sofitel Roma Villa Borghese, a top recommendation for dinner tonight. Or, for a change of pace, Centro boasts a menu that's sure to impress. Also, be sure to check out Ristorante Tema. Known as a local hotspot, it’s a great choice for tonight in Rome.

Say good night to Rome and look forward to another great day of your road trip in Italy!

Embark on another extraordinary experience on day 11 of your road trip in Italy. Today, you will make 1 stop and experience some of the highlights of Siena. At the end of the day, you will enjoy the comforts of a top-rated hotel in Siena, which will be your home away from home for 1 night.

Bring your curiosity for today’s adventure around Rome. Some of the city’s most loved attractions await! Fortezza Medicea (siena) is the perfect place to start. This monument is one of the most up-and-coming places to visit in Rome. Next, head to Basilica Of San Domenico, an underrated church, known for its picture-perfect features.

In between the sights, don’t hesitate to take small detours to explore local stores and eateries. When you’re ready to continue your adventure, head to Santuario Di Santa Caterina. This culturally significant church is a highly recommended experience. Visit these for an interesting touch to your journey.

When you’re done exploring for the day, you’ll drive to your hotel in Siena. Check in and spend some time relaxing before you head out to tour the city.

Indulge in a memorable dining experience at one of Siena's most popular restaurants, and connect with friendly locals for an authentic adventure.

Enjoy a delicious meal at Enoteca I Terzi, a top-rated dining destination in Siena. If you're in the mood to try something new, consider Ristorante Tar-Tufo, another top spot with a mouthwatering menu. You might also want to secure a reservation at Antica Trattoria Papei. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Siena this evening.

Following your dinner, dive into the local bar culture at Meet Life Cafè. Enjoy this evening's relaxed ambiance with delightful drinks. Alternatively, go to Maudit Pub, the perfect place for those looking to experience the best of the nightlife. Similarly, Bar Impero Siena provides excellent drinks and a great atmosphere, ensuring a memorable night out.

Raise your glass to another unforgettable day in Italy!

Experience an unparalleled adventure on day 12 of your road trip in Italy. This exciting part of your journey invites you to discover the renowned landmarks in 1 vibrant destinations - Pisa. After a day filled with exploration and new experiences, you will retreat to the hotel of your choice in Genoa. You will spend 1 night here for some well-deserved relaxation.

Siena is brimming with adventures. Today’s wonderful stops include a monument, a church, a public square, a cemetery and much more! Begin your sightseeing adventure at the iconic Leaning Tower Of Pisa and allow yourself time to explore. Just a short distance away you'll find your next stop, Pisa Cathedral, an UNESCO world heritage-listed church that draws visitors from far and near.

Continue your journey to Piazza Del Duomo, Pisa, one of the city’s most world-famous spots that you shouldn’t miss. Another great site to visit is the beloved Campo Santo.

At the end of the day, you will drive to Genoa, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

As dinnertime approaches, it's time to head out for a bite to eat in Genoa. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.

Treat yourself to a delicious dinner at Vivarelli, an excellent option for tonight's dining. Looking for something different? Trattoria Ugo offers a tantalizing alternative with its diverse menu. And don’t miss TAZZE PAZZE Specialty Coffee. With its reputation for pleasing customers, it’s a fantastic choice for tonight in Genoa.

Say good night to Genoa and look forward to another great day of your road trip in Italy!