13-Day Italy Road Trip from Rome to Siena, Bologna, Milan, Genoa, and Florence

Day 2 offers a multitude of experiences. You will stay in Rome for 2 nights more, offering you enough time to explore at a relaxed pace.

Drop by the renowned Castel Sant'angelo. This popular museum has been rated an average of 4.7 out of 5 stars by 72,431 visitors. Based on recent data, this attraction is visited by more than 918,591 travelers every year.

Another unforgettable place to experience is Piazza Navona. Rated 4.7 out of 5 stars by 158,771 visitors, this square deserves a spot on today's sightseeing itinerary.

We also recommend a visit to Campo De' Fiori. This square has been rated an average of 4.4 out of 5 stars in 51,133 reviews.

Another favorite attraction in the area is Roman Forum. This square and popular place of interest enjoys a rating of 4.7 out of 5 stars from 114,450 local and international travelers.

If you’re keen to explore even more, then consider a visit to Colosseum. This roman amphitheatre gets around 7,400,000 annual visitors. With an average rating of 4.7 out of 5 stars from 328,821 travelers, this roman amphitheatre is an attraction many avid travelers highly recommend visiting while in Rome.

Don’t forget to check out all the popular tours and activities you can add to your travel plan. Italy is a beautiful travel destination that offers plenty of unique tours that will enhance your vacation experience. Explore and select your activities below.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Rome. Enjoy a relaxing evening as you savor delicious local cuisine and reflect on the day's adventures.

Enjoy an outstanding dining experience at La Pergola, a 3-star Michelin restaurant offering an exceptional mediterranean, and contemporary menu. If you are in the mood for trying an alternative dining experience, consider visiting the nearby 2-star Michelin-awardee, Il Pagliaccio, known for its delicious creative, and innovative cuisine. Another highly-recommended restaurant in Rome is Enoteca La Torre, a renowned restaurant with a 2-star Guide Michelin recognition, known for its delicious mediterranean, and creative menu.

To truly maximize your evening out, consider visiting The Apartment Bar Roma after dinner. This bar is known for offering some of the best drinks and vibes in the city. Alternatively, head to Hotel Hassler Roma, another bar with an inviting ambiance.

Raise your glass to another unforgettable day in Italy!

On day 3 of your road trip, you will have an entire day to explore Rome. You’ll stay in Rome for 1 night and discover all the best things to see and do in the area.

Kick off the day at Villa Borghese, a top pick for today’s sightseeing. This urban zone of rome is rated an average of 4.6 out of 5 stars in 69,749 reviews.

Today is also your chance to visit Piazza Del Popolo. Piazza Del Popolo is a square with an average rating of 4.6 out of 5 stars from 89,807 reviews.

Spanish Steps is another top attraction we highly recommend you visit today. This monumental staircase is rated an average of 4.5 out of 5 stars by 57,211 visitors.

Beyond the attractions mentioned above, you also have the opportunity to visit Piazza Di Spagna. This square is rated an average of 4.7 out of 5 stars by 113,658 visitors.

Lastly, don’t miss out on Pantheon, a famous roman temple in Rome. This attraction welcomes 30,000,000 visitors annually and is rated an average of 4.8 out of 5 stars by 189,682 travelers.

There are plenty of experiences you can choose from in Italy that will add excitement to your vacation. When you’re keen to discover what else Rome has in store for you, use this day to go on a tour. Scroll down and select tours and activities to include on your itinerary for the day.

As dinnertime approaches, it's time to head out for a bite to eat in Rome. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.

Have a fantastic dining experience at Ristorante Tema, a highly recommended choice for tonight's dinner. If you're looking to mix things up, Maccheroni offers an enticing alternative with its varied menu. Additionally, RoYaL Art Cafè Roma is worth considering. Renowned for satisfying diners, it’s an ideal option for tonight in Rome.

Get a good night's sleep and look forward to another great day on the road in Italy!

Embark on another extraordinary experience on day 4 of your road trip in Italy. Today, you will make 1 stop and experience some of the highlights of Vatican City. At the end of the day, you will enjoy the comforts of a top-rated hotel in Siena, which will be your home away from home for 1 night.

As you’ve unraveled the marvels of Rome, it’s time to gear up for the next part of your road trip adventure. Set course for Vatican City! Under favorable conditions, your drive to Vatican City may take around 11 min. Upon your arrival in Vatican City, you’ll be greeted with the opportunity to do some sightseeing and exploring.

An excellent attraction to start your day with is St. Peter's Basilica. This major basilica typically receives around 11,000,000 visitors every year and is rated an average of 4.8 out of 5 stars in 131,043 reviews.

Continue your journey at Sistine Chapel. This chapel is rated 4.7 out of 5 stars by 52,083 travelers from near and far.

Vatican City is also the home of Saint Peter's Square. This square has an average rating of 4.8 out of 5 stars from 38,954 visitors.

You can continue your self-guided sightseeing tour at Vatican Museums. A total of 1,612,530 people explore this attraction every year. Rated 4.6 out of 5 stars by 133,310 visitors, a visit to this top sight is time well spent.

After soaking up all the sights of today's itinerary, you'll be ready to hit the road in the direction of your accommodation in Siena. Siena offers plenty of top-rated hotels and other places to stay on any travel budget. Take some time to relax before you head out to explore.

As you explore more of Siena, you'll discover that its culinary landscape is as diverse as its attractions. Whether you're craving traditional dishes bursting with local flavors or innovative creations that push the boundaries of taste, you're sure to find a dining experience that satisfies your cravings.

Have a fantastic dining experience at Antica Trattoria Papei, a highly recommended choice for tonight's dinner. If you're looking to mix things up, Osteria Quattro Venti offers an enticing alternative with its varied menu. Additionally, Osteria da Divo is worth considering. Renowned for satisfying diners, it’s an ideal option for tonight in Siena.

After your delicious meal, get a taste of the vibrant nightlife with a visit to Meet Life Cafè, known for its inviting atmosphere. Maudit Pub is another great option if you’re looking for a place to get the night started. Similarly, Bar Impero Siena provides a great setting to enjoy the night away.

Raise your glass and celebrate another amazing day of your road trip in Italy!

Dive into day 5 of your remarkable road trip in Italy. Today you will explore Siena, where you will have the opportunity to experience all the top things to see and do. At the end of the day, you’ll unwind at one of the finest accommodations in Bologna. You’ll stay here for 1 night.

Your sightseeing of the day begins at Piazza Del Campo, a remarkable square where it’s easy to get lost in exploration. This top attraction is rated an average of 4.8 out of 5 stars in 64,175 reviews.

Next, satisfy your wanderlust at Basilica Of San Domenico. This minor basilica has an average rating of 4.6 out of 5 stars from 3,290 travelers.

Piazza Del Duomo is another must-visit attraction. This renowned square offers a memorable experience, well worth a stop on your self-guided sightseeing tour. Rated 4.7 out of 5 stars by 211 travelers, it's one of the more popular places to see in the area.

Beyond the above-mentioned sites, you also have the opportunity to visit Siena Cathedral. This well-loved domus boasts a 4.8 out of 5-star rating from 21,656 reviews.

When you’re done exploring for the day, you’ll drive to Bologna, where you'll have a hotel waiting for you. Check in and spend some time relaxing before you head out to explore the city.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Bologna. Enjoy a relaxing evening as you savor delicious local cuisine and reflect on the day's adventures.

Set out on a gastronomic journey in Bologna by reserving a table at Ahimè. Renowned for its Bib Gourmand award, this restaurant presents an outstanding menu of country cooking cuisine. For a different taste, head over to I Portici, renowned for its delectable creative, and contemporary dishes. This distinguished 1-star Michelin-recipient is a favorite among guests, making it a worthy addition to your holiday plans. Craving more culinary excitement? Explore Trattoria di Via Serra, a highly rated local gem known for its exquisite emilian menu. With a Bib Gourmand acclaim, it promises a dining experience you won't want to miss. With its reputation for pleasing customers, it’s a fantastic choice for tonight in Bologna.

To truly maximize your evening out, consider visiting Bar Freud E Squisito after dinner. This bar is known for offering some of the best drinks and vibes in the city. Alternatively, head to Osteria Del Sole, another bar with an inviting ambiance. Similarly, Macondo - Cocktail Bar also offers a great atmosphere, ensuring a night filled with enjoyment and relaxation.

Get a good night's sleep and look forward to another great day on the road in Italy!

On day 6 of your exciting self-drive vacation in Italy, you’ll soak in the magnificence of 1 destination, Bologna. When you’re not sightseeing, take time to relax at your selected hotel in Milan, where you’ll be staying for 2 nights.

Make Palazzo D'accursio one of your first sightseeing stops in Bologna. Rated an average of 4.6 out of 5 stars by 969 travelers, a visit to this local attraction makes for a great introduction to the area.

Piazza Maggiore is a worthwhile attraction you can visit next. This square is a valued place of interest in the area, with an average rating of 4.7 out of 5 stars from 64,523 reviews.

Today is also the perfect opportunity to drop by Two Towers. This tower has been rated an average of 4.7 out of 5 stars by 25,975 visitors.

If you’re keen to explore more, head to Bologna Cathedral. A trip to this popular catholic cathedral is also your opportunity to see if it lives up to the reputable 4.6 out of 5-star rating as given by 3,852 previous visitors.

Another top place to visit is Fountain Of Neptune, Bologna. This fountain enjoys an average rating of 4.7 out of 5 stars from 3,952 local and international travelers.

At the end of the day, you will drive to Milan, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Milan. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Enjoy an outstanding dining experience at Enrico Bartolini al Mudec, a 3-star Michelin restaurant offering an exceptional creative menu. If you are in the mood for trying an alternative dining experience, consider visiting the nearby 2-star Michelin-awardee, Seta by Antonio Guida, known for its delicious international, and contemporary cuisine. Another highly-recommended restaurant in Milan is Il Luogo Aimo e Nadia, a renowned restaurant with a 1-star Guide Michelin recognition, known for its delicious italian contemporary, and modern menu.

Round off your dining experience by visiting Nottingham Forest, a prime location for a drink. Alternatively, explore the distinctive characteristics of Armani/bamboo Bar, a bar catering to every mood and preference. Mag Cafe likewise offers a unique atmosphere, perfect for a memorable night out.

Head back to your accommodation in Milan and get some rest in preparation for another magical day of your road trip in Italy!

Day 7 of your road trip across Italy promises a magnificent time exploring Milan. You have 1 night left in Milan. Take the opportunity to experience more of the best attractions and activities in the city.

A top pick for your self-guided sightseeing tour today is Piazza Gae Aulenti. Previous visitors have rated this square an average of 4.6 out of 5 stars in 30,398 reviews.

Arch Of Peace is a local recommendation that you also can pay a visit today. This monument is rated an average of 4.6 out of 5 stars in 27,502 reviews.

Another attraction you won't want to miss is Parco Sempione. This park is rated an average of 4.6 out of 5 stars in 72,914 reviews.

Sforzesco Castle Art Library is another outstanding experience in Milan. Around 68,714 travelers have rated this library an average of 4.6 out of 5 stars.

If you long for more, Pinacoteca Di Brera is not far away. This art museum is a lovely addition to your itinerary. Previous visitors have rated it an average of 4.7 out of 5 stars in 26,077 reviews.

One of the most unique ways of discovering what else Milan has to offer is by going on a top-rated tour. Be sure to check out all the experiences Milan offers and add your favorites to your Italy travel package below.

As you explore more of Milan, you'll discover that its culinary landscape is as diverse as its attractions. Whether you're craving traditional dishes bursting with local flavors or innovative creations that push the boundaries of taste, you're sure to find a dining experience that satisfies your cravings.

Enjoy a delicious meal at Nero 9, a top-rated dining destination in Milan. If you're in the mood to try something new, consider Ristorante la Brisa, another top spot with a mouthwatering menu. You might also want to secure a reservation at UNAHOTELS Cusani Milano. With a reputation for consistently satisfied customers, it’s a perfect choice to enhance your stay in Milan this evening.

Round off your dining experience by visiting Kilburn Cocktail Bar Milano, a prime location for a drink. Alternatively, explore the distinctive characteristics of Bar Frida, a bar catering to every mood and preference. The Friends Pub Milano likewise offers a unique atmosphere, perfect for a memorable night out.

Savor another day of unforgettable experiences in Italy!

Experience an unparalleled adventure on day 8 of your road trip in Italy. This exciting part of your journey invites you to discover the renowned landmarks in 1 vibrant destinations - Milan. After a day filled with exploration and new experiences, you will retreat to the hotel of your choice in Genoa. You will spend 1 night here for some well-deserved relaxation.

Journey into the unknown at Cathedral Square, a unique attraction awaiting your visit. This remarkable point of interest has an average rating of 4.8 out of 5 stars from 7,539 reviews.

When you’re ready to continue your sightseeing, La Scala is a recommended place to visit. This opera house is rated an average of 4.7 out of 5 stars in 26,219 reviews.

Another must-see attraction in Milan is Galleria Vittorio Emanuele Ii. Rated an average of 4.7 out of 5 stars by 91,394 travelers, this popular tourist destination in Milan offers an experience you will remember.

Duomo Di Milano Museum is another popular stop on travelers' itineraries in Milan. This art museum promises memorable moments of exploring. Other travelers have rated this attraction 4.8 out of 5 stars in 138,554 reviews. Each year, approximately 341,609 people travel to visit Duomo Di Milano Museum.

Lastly, don't miss out on Royal Palace Of Milan. Rated 4.6 out of 5 stars by 17,538 local and international travelers, it's a popular place to visit.

After soaking up all the sights of today's itinerary, you'll be ready to hit the road in the direction of your accommodation in Genoa. Genoa offers plenty of top-rated hotels and other places to stay on any travel budget. Take some time to relax before you head out to explore.

Indulge in a memorable dining experience at one of Genoa's most popular restaurants, and connect with friendly locals for an authentic adventure.

Treat yourself to an extraordinary dining experience at San Giorgio, a 1-star Michelin restaurant offering an incredible modern, and ligurian menu. Alternatively, if your taste buds call for something different, The Cook is one of the best restaurants for modern cuisine in Genoa. This 1-star Michelin-awardee earns consistently high praises from guests. We also recommend checking out the menu at Il Marin. As a top-rated establishment with 1 Michelin star, it is an ideal choice for seafood, and contemporary cuisine in the city.

Following your dinner, dive into the local bar culture at Scurreria Beer & Bagel. Enjoy this evening's relaxed ambiance with delightful drinks. Alternatively, go to La Lepre, the perfect place for those looking to experience the best of the nightlife.

Relax and reminisce about your day in Italy and look forward to more memorable moments to come!

On day 9 of your road trip in Italy, you will get a true taste of the freedom a self-drive vacation in Europe entails. Today’s travel plans include stops at the most scenic, wondrous, and interesting places in Genoa, and Pisa. In the evening, you’ll end up in Florence, where you will stay for 3 nights.

Begin your sightseeing with a visit to Piazza De Ferrari. This extraordinary square is rated an average of 4.6 out of 5 stars by 34,312 visitors.

Next, make your way to Aquarium Of Genoa. This top attraction is a public aquarium with an average rating of 4.5 out of 5 stars by 62,259 visitors. Aquarium Of Genoa welcomes 1,200,000 yearly visitors.

Fasten your seatbelt and make your way to your next stop. Pisa, home to many well-known sights in the region, is a lovely destination on today’s itinerary. Keep in mind that your travel time from Genoa to Pisa may take around 2 hours 5 min without traffic disruptions. Upon arrival in Pisa, we highly recommend checking out some of the top attractions.

Begin your sightseeing with a visit to Leaning Tower Of Pisa. This bell tower gets 3,200,000 visitors each year and is rated an average of 4.7 out of 5 stars in 116,882 reviews.

Next up, make your way to Piazza Del Duomo, Pisa. This square has an average rating of 4.7 out of 5 stars from 104,550 reviews.

When you’re done exploring for the day, you’ll drive to Florence, where you'll have a hotel waiting for you. Check in and spend some time relaxing before you head out to explore the city.

As dinnertime approaches, it's time to head out for a bite to eat in Florence. If you are looking to dine at a popular restaurant in the city, it's often a good idea to reserve a table in advance.

Begin your culinary exploration in Florence by securing a reservation at Enoteca Pinchiorri. This renowned restaurant holds 3 Michelin star and offers an exceptional menu of italian contemporary cuisine. For another dining delight, visit Santa Elisabetta, celebrated for its delectable creative, and mediterranean menu. This acclaimed 2-star Michelin-recipient consistently leaves guests satisfied, making it a must-visit during your holiday. Looking for a different experience? Discover Gucci Osteria da Massimo Bottura, a top local spot known for its tantalizing italian contemporary, and international menu. With a 1-star Michelin recognition, it guarantees an exceptional dining adventure.

Cap off your dinner by heading to Manifattura, ideal for a leisurely evening with a drink in hand. Se·sto On Arno Rooftop Bar is another bar that offers an enjoyable setting. Similarly, Archea Brewery is also a popular place to go on a night out, perfect for relaxing and socializing.

As the day draws to a close, take a moment to unwind and prepare for the next exciting chapter of your road trip in in Italy.

Day 10 of your road trip will take you to the best attractions Florence has to offer. Cherish the 2 nights you have left in Florence by discovering the best things there are to see and do in the city.

When you're ready to see some sights, Cathedral Of Santa Maria Del Fiore is a great place to start. This church is rated an average of 4.8 out of 5 stars by 76,359 visitors.

Another popular attraction you can visit today is Piazza Della Repubblica. This square has an average rating of 4.6 out of 5 stars from 22,356 travelers.

We also recommend a stop at Piazza Della Signoria. The square has been rated an average of 4.8 out of 5 stars by 66,956 visitors.

If you're keen to explore more, consider visiting Uffizi Gallery. This national museum is a popular attraction with an average rating of 4.7 out of 5 stars from 61,794 reviews. As a top-rated attraction, it's no surprise that 2,011,219 people visit Uffizi Gallery every year.

Ponte Vecchio is another easily accessible place to visit on this day of your trip. Stop by this deck arch bridge, rated 4.7 out of 5 stars in 118,099 reviews, to discover more of what makes it unique.

Immerse yourself in the local scene through top-rated tours and activities. You can choose from a wide variety of easy to challenging tours and easily add them to your travel package below.

After a day of adventure, treat yourself to an exquisite dinner at one of Florence's best restaurants.

Treat yourself to a delicious dinner at Trattoria Da Burde, an excellent option for tonight's dining. Looking for something different? Ristorante Buca Mario offers a tantalizing alternative with its diverse menu. And don’t miss Eataly Firenze. With its reputation for pleasing customers, it’s a fantastic choice for tonight in Florence.

Raise your glass and celebrate another amazing day of your road trip in Italy!

Day 11 offers a multitude of experiences. You will stay in Florence for 1 night more, offering you enough time to explore at a relaxed pace.

Make Central Market one of your first sightseeing stops in Florence. Rated an average of 4.4 out of 5 stars by 43,100 travelers, a visit to this local attraction makes for a great introduction to the area.

Basilica Di Santa Maria Novella, Firenze (fi) is a worthwhile attraction you can visit next. This archives is a valued place of interest in the area, with an average rating of 4.7 out of 5 stars from 23,075 reviews.

Today is also the perfect opportunity to drop by Pitti Palace. This art museum has been rated an average of 4.6 out of 5 stars by 23,445 visitors. Up to 198,270 people travel to this site annually.

If you’re keen to explore more, head to The Boboli Gardens. A trip to this popular park is also your opportunity to see if it lives up to the reputable 4.2 out of 5-star rating as given by 25,341 previous visitors.

Another top place to visit is Piazzale Michelangelo. This square enjoys an average rating of 4.8 out of 5 stars from 77,744 local and international travelers.

To immerse yourself in more memorable moments in Florence, check out the best-rated tours the region offers. You can discover and choose from all of the top-rated activities you can do on this day in Florence below.

Indulge in a memorable dining experience at one of Florence's most popular restaurants, and connect with friendly locals for an authentic adventure.

Savor the flavors at Tijuana, a top pick for dinner tonight. Alternatively, Djària - American Bar beckons with its unique menu offerings. Also, consider Ristorante Buca Niccolini. With its consistent customer satisfaction, it’s an excellent option for dining in Florence tonight.

Take some time to reflect on your day and savor another beautiful night in Italy.

Embark on another extraordinary experience on day 12 of your road trip in Italy. Today, you will make 2 stops and experience some of the highlights of Florence, and Orvieto. At the end of the day, you will enjoy the comforts of a top-rated hotel in Rome, which will be your home away from home for 1 night.

When you're ready to see some sights, Basilica Of Santa Croce In Florence is a great place to start. This church is rated an average of 4.7 out of 5 stars by 28,544 visitors.

Another popular attraction you can visit today is Galleria Dell'accademia. This national museum has an average rating of 4.6 out of 5 stars from 34,429 travelers. Every year, 1,719,645 travelers come to experience this site to make the most of their time in Florence.

We also recommend a stop at David. The statue has been rated an average of 4.8 out of 5 stars by 10,476 visitors.

When you’ve had your share of Florence, prepare for your next destination. Admire the views and listen to some good music as you drive in the direction of Orvieto. Your travel time is around 1 hour 53 min.

Journey into the unknown at Well Of St. Patrick, a unique attraction awaiting your visit. This remarkable sightseeing destination has an average rating of 4.5 out of 5 stars from 14,274 reviews.

At the end of the day, you will drive to Rome, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

After a day of adventure, treat yourself to an exquisite dinner at one of Rome's best restaurants.

Make sure to reserve a table at Harry's Bar, an iconic dining spot in Rome. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Ristorante Amedeo, a popular restaurant in Rome. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of VinAllegro, a hidden gem nestled in Rome. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

Relax and recharge in preparation for another adventurous day in Italy!