14-Day Italy Self-Drive Road Trip With Itinerary from Brindisi to Lecce, Alberobello, Matera, Naples, and Rome

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Ostuni white town skyline at sunset, Brindisi, Apulia southern Italy. Europe.

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Experience the freedom of the open road on an unforgettable 14-day road trip in Italy! Embark on a self-drive tour that caters to every traveler, featuring destinations like Brindisi, Lecce, Alberobello, Matera, Pompei, Naples, Positano, Ravello, Amalfi, Rome, Carovigno, and Ostuni.

This perfectly planned road trip itinerary takes you through some of the best places to see in Italy. You will spend 2 nights in Brindisi, 2 nights in Lecce, 1 night in Alberobello, 2 nights in Matera, 3 nights in Naples, and 3 nights in Rome. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Italy. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have you covered.

Upon arriving in Brindisi, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Italy on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Italy. Trevi Fountain and Colosseum are just a couple of the bucket-list attractions that await your discovery.

As you hit the open road and drive through Brindisi, Lecce, Alberobello, Matera, Pompei, Naples, Positano, Ravello, Amalfi, Rome, Carovigno, and Ostuni, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Italy. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Italy.

Throughout your road trip in Italy, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Italy.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodations, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in Italy fill up quickly, so book your spot early. Select a date and start planning your road trip in Italy today!

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Driver’s age is 30 - 65

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Day 1

Brindisi - Arrival day
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Colonne Romane
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Say hello to Brindisi! Your exciting road trip through Italy is just about to start. Navigating the top places to see in the region is a breeze with a car. The rental vehicle of your choice will be ready for pickup upon your arrival in the city. You will stay in Brindisi for 1 night before you continue your adventure!

Brindisi is a beautiful city with plenty to discover. Taking a stroll in the city center is a great alternative. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

As afternoon approaches, head to your chosen hotel in Brindisi. Check-in typically starts around 2 to 4 PM at hotels in Italy. We recommend staying at a central location for easy access to key areas in the city.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Brindisi, it's often a good idea to reserve a table in advance.

Raise a toast to the start of your 14-day road trip in Italy!

Day 2

Brindisi
Lecce
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Drive 38 km, 47 min

Chiesa Rettoria del Santissimo Crocifisso
Giardini Pubblici Giuseppe Garibaldi - Villa Comunale
Palazzo dei Celestini (Provincia di Lecce)
Basilica di Santa Croce
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On day 2 of your road trip in Italy, your travel plans include 2 stops at the most scenic, wondrous, and interesting places in the region. Brindisi and Lecce are on today's agenda. In the evening, you’ll end up in Lecce, where you will stay for 2 nights.

When you’re done exploring for the day, you’ll drive to your hotel in Lecce. Check in and relax before you head out to tour the city.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Lecce, it's often a good idea to reserve a table in advance.

As the sun sets, rest up and recharge for the next leg of your road trip in Italy.

Day 3

Lecce
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Drive 2 km, 25 min

Gate of Saint Blaise
Museo Faggiano
Castello Carlo V
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Day 3 offers an itinerary packed with the best things to see in Brindisi. You’ll stay in Lecce for 1 night more, offering you enough time to explore at a relaxed pace.

Don’t forget to check out all the popular tours and experiences you can add to your travel plans in Italy. You can explore and select activities under each day of your itinerary.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Lecce. Enjoy a relaxing evening as you savor delicious local cuisine.

Relax and look forward to more memorable moments to come!

Day 4

Lecce
Alberobello
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Drive 115 km, 1 hour 31 min

Trulli di Alberobello Puglia
Territory Museum "House Pezzolla"
Casa D'Amore
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Your itinerary for day 4 of your road trip in Italy includes 1 stop and features some of the highlights of Alberobello. At the end of the day, enjoy the comforts of a top-rated hotel in Alberobello, where you'll spend 1 night.

At the end of the day, you will drive to Alberobello, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Alberobello. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Relax and look forward to more memorable moments to come!

Day 5

Alberobello
Matera
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Drive 70 km, 1 hour 18 min

Church of Saint Peter 'Barisano'
Chiesa di San Giovanni Battista
Palombaro lungo
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Experience an unparalleled adventure on day 5 of your road trip in Italy. This exciting part of your journey invites you to discover the renowned landmarks in 1 place, which are Matera. At the end of the day, you will retreat to the hotel of your choice in Matera, where will spend 2 nights.

After soaking up all the sights on today's itinerary, you'll be ready to head to your accommodation in Matera. Matera offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

After a day of adventure, treat yourself to an exquisite dinner at one of Matera's best restaurants.

Head back to your accommodation in Matera and get some rest to prepare for another magical day of your road trip in Italy.

Day 6

Matera
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Drive 29 km, 1 hour 9 min

Belvedere di Piazza Giovanni Pascoli
Casa Grotta del Casalnuovo
Casa Grotta nei Sassi di Matera
Church of Saint Mary of Idris
Sassi di Matera
MUSMA - Museo della Scultura Contemporanea
Crypt of Original Sin
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You’ll stay in Matera for 1 night.

Don’t forget to check out all the popular tours and experiences you can add to your travel plans in Italy. You can explore and select activities under each day of your itinerary.

Indulge in a memorable dining experience at one of Matera's most popular restaurants, and connect with friendly locals for a true cultural experience.

Raise your glass and celebrate another amazing day of your road trip in Italy!

Day 7

Matera
Naples
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Drive 253 km, 3 hours 54 min

Archaeological Park of Pompeii
Lupanar des esclaves
Teatro Grande
Amphitheatre of Pompeii
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Dive into day 7 of your remarkable road trip in Italy. Today you'll explore 1 destination, including Pompei. At the end of the day, you’ll unwind at one of the finest accommodations in Naples, where you'll spend 3 nights.

When you’re done exploring for the day, you’ll drive to your hotel in Naples. Check in and relax before you head out to tour the city.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Naples. Enjoy a relaxing evening as you savor delicious local cuisine.

As the day draws to a close, take a moment to unwind and prepare for the next exciting chapter of your road trip in Italy.

Day 8

Naples
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Drive 10 km, 1 hour 21 min

Castel Sant'Elmo
Naples National Archaeological Museum
Cappella Sansevero
Napoli Sotterranea Percorso Ufficiale
Spaccanapoli
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You have 2 nights left in Naples. Take the opportunity to experience more of the best attractions and activities in the city.

Whether you decide to get entrance tickets for all attractions or you prefer admiring from a distance, amazing experiences await on this day in Naples.

Don’t forget to check out all the popular tours and experiences you can add to your travel plans in Italy. You can explore and select activities under each day of your itinerary.

After a day of adventure, treat yourself to an exquisite dinner at one of Naples's best restaurants.

Take some time to reflect on your day and savor another beautiful night in Italy.

Day 9

Naples
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Drive 151 km, 4 hours 18 min

Costiera Amalfitana Positano
Fondazione Ravello
Villa Rufolo
Amalfi Coast
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On day 9 of your road trip, you’ll start and end your day in Naples, where you have 1 night left to stay.

When you’re done exploring the area’s best attractions, you’ll drive back to your accommodation in Naples.

After a day of adventure, treat yourself to an exquisite dinner at one of Naples's best restaurants.

Savor another day of unforgettable experiences in Italy!

Day 10

Naples
Rome
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Drive 232 km, 3 hours 30 min

Colosseum
Roman Forum
largo di Torre Argentina
Piazza Navona
Campo de' Fiori
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On day 10 of your exciting self-drive vacation in Italy, you’ll soak in the magnificence of 1 destination, including Rome. When you’re not sightseeing, take time to relax at your chosen hotel in Rome, where you’ll be staying for 3 nights.

Whether you decide to get entrance tickets for all attractions or you prefer admiring from a distance, amazing experiences await on this day in Naples.

At the end of the day, you will drive to Rome, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

Rome is a place where the culinary landscape is as diverse as its attractions. So before the day ends, treat your palate to a taste of local cuisine at one of the best restaurants in Rome.

Take some time to reflect on your day and savor another beautiful night in Italy.

Day 11

Rome
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Drive 15 km, 1 hour 36 min

Trevi Fountain
Altare della Patria
Castel Sant'Angelo
Pantheon
Piazza di Spagna
Spanish Steps
Via del Corso
Via dei Condotti
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Don’t forget to check out all the popular tours and experiences you can add to your travel plans in Italy. You can explore and select activities under each day of your itinerary.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Rome, it's often a good idea to reserve a table in advance.

As the day draws to a close, take a moment to unwind and prepare for the next exciting chapter of your road trip in Italy.

Day 12

Rome
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Drive 23 km, 1 hour 31 min

piazza del Popolo
Vatican Museums
St Peter's Basilica
Sistine Chapel
Borghese Gallery and Museum
Villa Borghese
Trastevere
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On day 12 of your road trip, you'll get the chance to experience Rome and Vatican City. At the end of the day, you'll drive back to Rome, where you still have 1 night left to stay.

When you’re done exploring for the day, you’ll return to Rome and your accommodation.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Rome. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Celebrate another amazing day of your road trip adventure in Italy!

Day 13

Rome
Brindisi
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Drive 573 km, 6 hours 34 min

Castello Dentice di Frasso di Carovigno
Colonna di Sant'Oronzo
CENTRO STORICO
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On day 13 of your road trip in Italy, your travel plans include 2 stops at the most scenic, wondrous, and interesting places in the region. Carovigno and Ostuni are on today's agenda. In the evening, you’ll end up in Brindisi, where you will stay for 1 night.

After soaking up all the sights on today's itinerary, you'll be ready to head to your accommodation in Brindisi. Brindisi offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

Indulge in a memorable dining experience at one of Brindisi's most popular restaurants, and connect with friendly locals for a true cultural experience.

Say good night to Brindisi and look forward to another great day of your road trip in Italy!

Day 14

Brindisi - Departure day
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Saint Pietro of Schiavoni Archeologica Area
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Day 14 of your road trip in Italy is your departure day. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Italy!

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Shortly after booking, you’ll receive your full itinerary, including schedules, locations, and everything you need for a stress-free trip.

Personalize your itinerary

Each package includes a professionally crafted itinerary you can tailor to your travel style. A dedicated travel expert will make sure every detail fits your needs perfectly.

Easily make changes

Need to update plans? No problem. Whether before your trip or mid-journey, we’re just seconds away to help with quick adjustments.

Enjoy seamless planning

With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.

Explore with confidence

From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.

Secure your spot

Confirm your package instantly and lock in the best rate with secure payment and guaranteed availability.

Get instant confirmation

Shortly after booking, you’ll receive your full itinerary, including schedules, locations, and everything you need for a stress-free trip.

Personalize your itinerary

Each package includes a professionally crafted itinerary you can tailor to your travel style. A dedicated travel expert will make sure every detail fits your needs perfectly.

Easily make changes

Need to update plans? No problem. Whether before your trip or mid-journey, we’re just seconds away to help with quick adjustments.

Enjoy seamless planning

With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.

Explore with confidence

From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.

We guarantee

Your trip is protected, personalized, and priced right. No surprises, no stress.

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