14-Day Italy Self-Drive Road Trip With Itinerary from Pisa traveling south to Perugia, Viterbo, Naples, Rome, Florence, and Genoa

On day 2 of your road trip in Italy, your travel plans include 1 stop at the most scenic, wondrous, and interesting places in the region. Pisa are on today's agenda. In the evening, you’ll end up in Perugia, where you will stay for 1 night.

Visiting Leaning Tower Of Pisa is always a good idea. This iconic monument is a place that is appreciated by travelers and locals alike. Next, immerse yourself in the picture-perfect wonders of Battistero Di San Giovanni, a must-see church in the city.

Consider stopping for a small bite to eat or a drink at a local eatery to keep your energy going. When you’re ready, continue your discovery with a visit to Piazza Del Duomo, Pisa. This wondrous public square offers an enriching experience. For a change of pace, head to Pisa Cathedral, where you can take in historic features.

When you’re done exploring for the day, you’ll drive to your hotel in Perugia. Check in and relax before you head out to tour the city.

Indulge in a memorable dining experience at one of Perugia's most popular restaurants, and connect with friendly locals for a true cultural experience.

Savor the flavors at Ristorante Settimo Sigillo, a top pick for dinner tonight. Alternatively, Caffè Baglioni beckons with its unique menu offerings. Also, consider Bar Pellas. With its consistent customer satisfaction, it’s an excellent option for dining in Perugia tonight.

If you’re not ready to end the night just yet, Tommi Bar offers a perfect venue to relax and savor a drink. Similarly, Valentina is well-suited for those looking to unwind in a social setting. Caffe Dal Perugino is another excellent spot to enjoy a nightcap after a delightful meal.

Relax and recharge in preparation for another adventurous day in Italy!

Your itinerary for day 3 of your road trip in Italy includes 2 stops and features some of the highlights of Santa Maria degli Angeli and Orvieto. At the end of the day, enjoy the comforts of a top-rated hotel in Viterbo, where you'll spend 1 night.

Whether you decide to get entrance tickets for all attractions or you prefer admiring from a distance, amazing experiences await on this day in Santa Maria degli Angeli.

Embrace the thrill of the open road as you wave goodbye to Perugia and set your GPS to Santa Maria degli Angeli. While on the road, immerse yourself in your favorite road trip tunes or sample the sounds from a local radio station. This car ride usually takes around 25 min. Upon reaching Santa Maria degli Angeli, unwind, observe, and explore. The best things to do, see, and eat are waiting for you.

Our first attraction recommendation in Santa Maria degli Angeli is Basilica Of Santa Maria Degli Angeli, a captivating church that draws attention for its symbolic features.

Santa Maria degli Angeli’s wonders await as you prepare for another journey on the road, leaving the breathtaking surroundings of Santa Maria degli Angeli behind. This drive usually takes around 9 min. Santa Maria degli Angeli welcomes you with a multitude of unique vacation experiences.

Spend your afternoon discovering Basilica Of San Francesco D'assisi, a locally renowned church known for its historic features.

Fasten your seatbelt and make your way to your next stop — Orvieto, home to many well-known sights in the region. Keep in mind that your travel time from Santa Maria degli Angeli to Orvieto may take around 1 hour 22 min without traffic disruptions. Upon arrival in Orvieto, we highly recommend checking out some of the top attractions.

Our first attraction recommendation in Orvieto is Orvieto Cathedral, a well-known church that draws attention for its romantic features.

At the end of the day, you will drive to Viterbo, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Viterbo, it's often a good idea to reserve a table in advance.

Say good night to Viterbo and look forward to another great day of your road trip in Italy!

Experience an unparalleled adventure on day 4 of your road trip in Italy. This exciting part of your journey invites you to discover the renowned landmarks in 1 place, which are Caserta. At the end of the day, you will retreat to the hotel of your choice in Naples, where will spend 2 nights.

Fasten your seatbelt and make your way to your next stop — Caserta, home to many well-known sights in the region. Keep in mind that your travel time from Viterbo to Caserta may take around 2 hours 53 min without traffic disruptions. Upon arrival in Caserta, we highly recommend checking out some of the top attractions.

Spend your afternoon discovering Palace Of Caserta, a locally renowned palace known for its visually striking features. Next, continue your sightseeing at Fountain Of Aeolus, an underrated park.

If you're starting to feel hungry, this is a great time for a break at a nearby restaurant or cafe. When you're ready for more, stop by Giardini Reali - Parco Reggia Di Caserta and uncover the details of this romantic park.

After soaking up all the sights on today's itinerary, you'll be ready to head to your accommodation in Naples. Naples offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

Naples is a place where the culinary landscape is as diverse as its attractions. So before the day ends, treat your palate to a taste of local cuisine at one of the best restaurants in Naples.

Get ready for an unforgettable culinary journey in Naples by reserving a table at Veritas. Renowned as a 1-star Michelin restaurant, it offers an exceptional campanian and contemporary menu. For a different taste experience, head to Il Comandante, recognized for its delicious creative and mediterranean dishes. This 1-star Michelin restaurant consistently impresses guests, ensuring a memorable addition to your holiday. Looking for another option? Make sure to visit ARIA, a local favorite known for its delightful contemporary and modern cuisine in Naples. Nestled in the heart of the city, this restaurant with 1 Michelin star is an ideal choice for contemporary and modern foodies seeking culinary excellence.

Continue your evening by exploring the vibrant nightlife scene at Happening Cocktail Bar, a prime destination for a thrilling night out. Also, don’t forget to check out Shanti Art Musik Bar, a bar that offers unique local touches. Likewise, Gran Caffè Gambrinus provides an excellent alternative for a fun evening.

Raise your glass to another unforgettable day in Italy!

Dive into day 6 of your remarkable road trip in Italy. Today you'll explore 1 destination, including Naples. At the end of the day, you’ll unwind at one of the finest accommodations in Rome, where you'll spend 4 nights.

No visit to Naples is complete without Piazza Del Plebiscito. This widely recognized public square is one of the top attractions in the city. Proceed to Ovo Castle, another must-visit attraction.

As you wander through the inviting streets of Naples, soak in the lively ambiance and take the opportunity to snap some photos. Next, head to Naples National Archaeological Museum. This well-known museum is a traveler-favorite. Not far away, you’ll find Cappella Sansevero, another key site on your sightseeing itinerary.

When you’re done exploring for the day, you’ll drive to your hotel in Rome. Check in and relax before you head out to tour the city.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Rome. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Begin your culinary exploration in Rome by securing a reservation at La Pergola. This renowned restaurant holds 3 Michelin star and offers an exceptional menu of mediterranean and contemporary cuisine. For another dining delight, visit Il Pagliaccio, celebrated for its delectable creative and innovative menu. This acclaimed 2-star Michelin-recipient consistently leaves guests satisfied, making it a must-visit during your holiday. Looking for a different experience? Discover Enoteca La Torre, a top local spot known for its tantalizing mediterranean and creative menu. With a 2-star Michelin recognition, it guarantees an exceptional dining adventure.

After your delicious meal, get a taste of the vibrant nightlife with a visit to La Botticella Of Poggi Giovanni, known for its inviting atmosphere. Almalu Trastevere is another great option if you’re looking for a place to get the night started. Similarly, Bar Viminale Di Pepi Maurilio provides a great setting to enjoy the night away.

Raise your glass and celebrate another amazing day of your road trip in Italy!

Day 7 of your road trip will take you to the best attractions Rome has to offer. Cherish the 3 nights you have left in the city and use the provided itinerary to discover what to see in Rome.

Visiting Colosseum is always a good idea. This globally renowned archeological site is a place that is appreciated by travelers and locals alike. Next, immerse yourself in the UNESCO world heritage-listed wonders of Roman Forum, a must-see archeological site in the city.

Consider stopping for a small bite to eat or a drink at a local eatery to keep your energy going. When you’re ready, continue your discovery with a visit to Altare Della Patria. This notable monument offers an enriching experience. For a change of pace, head to Piazza Del Popolo, where you can take in enchanting features. Conclude your self-guided sightseeing tour with a visit to Villa Borghese These sights offer a fulfilling end to a perfect day.

Don’t forget to check out all the popular tours and experiences you can add to your travel plans in Italy. You can explore and select activities under each day of your itinerary.

After a day of adventure, treat yourself to an exquisite dinner at one of Rome's best restaurants.

Savor the flavors at RomAntica, a top pick for dinner tonight. Alternatively, Coso Ristorante beckons with its unique menu offerings. Also, consider DEROMA - Farine Romane. With its consistent customer satisfaction, it’s an excellent option for dining in Rome tonight.

After enjoying a fulfilling meal, continue your evening at Sant' Eustachio Caffè, ideal for those looking to unwind with a drink in a comfortable setting. Alternatively, Yellowsquare Rome offers a welcoming atmosphere for easing into the nightlife. Similarly, Caffè Portofino provides an excellent environment for a relaxed and enjoyable evening.

Celebrate another amazing day of your road trip adventure in Italy!

Day 8 offers an itinerary packed with the best things to see in Pisa. You’ll stay in Rome for 2 nights more, offering you enough time to explore at a relaxed pace.

Your adventure in Rome is only getting started when you visit Circus Maximus, a well-known local hot spot. Another notable attraction to explore is Trevi Fountain. This world-famous monument is known for its breathtaking appeal.

After soaking in the highlights of these sights, take some time to wander Rome's streets and immerse yourself in the local atmosphere. When you're ready to continue your sightseeing adventure, head to Spanish Steps. This culturally significant public square offers a fascinating experience that many visitors find memorable. Piazza Di Spagna is also worth visiting, along with Basilica Di Santa Maria Maggiore. These standout landmarks offer unique experiences that add to the day’s enjoyment.

Don’t forget to check out all the popular tours and experiences you can add to your travel plans in Italy. You can explore and select activities under each day of your itinerary.

Rome is a place where the culinary landscape is as diverse as its attractions. So before the day ends, treat your palate to a taste of local cuisine at one of the best restaurants in Rome.

Make sure to reserve a table at Hotel de Russie, an iconic dining spot in Rome. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of La Taverna Italiana, a popular restaurant in Rome. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of The Parrot Bar, a hidden gem nestled in Rome. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

Explore the vibrant nightlife at The Apartment Bar Roma after your meal, a hub for lively evenings and memorable moments. Or, head to Hotel Hassler Roma for a great selection of flavorful drinks and a charming setting.

Say good night to Rome and look forward to another great day of your road trip in Italy!

On day 9 of your road trip, you will have an entire day to discover what to see in Rome. You’ll stay in Rome for 1 night.

Check out the spectacular castle, Castel Sant'angelo. Afterward, continue to Piazza Navona, a public square every traveler should visit. As you explore Rome’s charming streets, take in the lively atmosphere and get to know the character of the city.

Next, make your way to Pantheon. This wondrous monument is an essential stop. Following that, head to Largo Di Torre Argentina, another must-visit site that will enhance your experience. Don’t forget to stop by Campo De' Fiori, an astonishing public square in the city.

Don’t forget to check out all the popular tours and experiences you can add to your travel plans in Italy. You can explore and select activities under each day of your itinerary.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Rome, it's often a good idea to reserve a table in advance.

Have a fantastic dining experience at Sofitel Roma Villa Borghese, a highly recommended choice for tonight's dinner. If you're looking to mix things up, Centro offers an enticing alternative with its varied menu. Additionally, Ristorante Tema is worth considering. Renowned for satisfying diners, it’s an ideal option for tonight in Rome.

Raise your glass and celebrate another amazing day of your road trip in Italy!

On day 10 of your exciting self-drive vacation in Italy, you’ll soak in the magnificence of 2 destinations, including Vatican City and Tivoli. When you’re not sightseeing, take time to relax at your chosen hotel in Florence, where you’ll be staying for 2 nights.

It’s time to gear up for the next part of your road trip adventure. Set course for Vatican City! Under favorable conditions, your drive to Vatican City may take around 10 min. Upon your arrival in Vatican City, you’ll be greeted with the opportunity to do some sightseeing and exploring.

When you're ready for some sights, head to Saint Peter's Square, an interesting square in Vatican City. This iconic major basilica is a top recommendation in the area.

When you’ve had your share of Vatican City, prepare for your next destination. Admire the views and listen to some good music as you drive in the direction of Tivoli, Italy. Your travel time is around 53 min.

Enjoy sightseeing at your own pace and allow yourself time to explore the beautiful surroundings. Take your self-guided tour to Villa D'este, a well-known palace that everyone visiting Tivoli should see. Next, head to Fontana Dell'organo. This noteworthy monument is one of the most underrated attractions in the region.

At the end of the day, you will drive to Florence, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

After a day of adventure, treat yourself to an exquisite dinner at one of Florence's best restaurants.

Set out on a gastronomic journey in Florence by reserving a table at Enoteca Pinchiorri. Renowned for its 3-star Michelin recognition, this restaurant presents an outstanding menu of italian contemporary cuisine. For a different taste, head over to Santa Elisabetta, renowned for its delectable creative and mediterranean dishes. This distinguished 2-star Michelin-recipient is a favorite among guests, making it a worthy addition to your holiday plans. Craving more culinary excitement? Explore Gucci Osteria da Massimo Bottura, a highly rated local gem known for its exquisite italian contemporary and international menu. With a 1-star Michelin acclaim, it promises a dining experience you won't want to miss.

Extend your evening after a delightful meal by visiting Manifattura, which offers the perfect atmosphere for a night out. Moreover, Se·sto On Arno Rooftop Bar is another popular option for a drink or two. Likewise, Il Vinile also provides a great ambiance for reminiscing about the day and raising a toast to your vacation.

Savor another day of unforgettable experiences in Italy!

Greet day 11 of your road trip in Italy with a smile and start your day with a hearty breakfast. You have 1 night to stay in Florence, so get ready to make the most of your time in the region. On the agenda for this day, you’ll find only the best things to see and do in Siena and Florence.

Siena is brimming with adventures.

Enjoy all that Piazzale Michelangelo has to offer. This is an astonishing observation deck you should not miss. Another must-see is Galleria Dell'accademia, an interesting art gallery in Florence.

When you’re ready for the next sight, head to Central Market.

It’s time to gear up for the next part of your road trip adventure. Under favorable conditions, your drive to Siena may take around 1 hour 16 min. Upon your arrival in Siena, you’ll be greeted with the opportunity to do some sightseeing and exploring.

Our first attraction recommendation in Siena is Piazza Del Campo, a top-rated public square that draws attention for its romantic features. Spend some time soaking in the atmosphere before continuing to Siena Cathedral, a symbolic church that stands out in the city.

When you’re done exploring the area’s best attractions, you’ll drive back to your accommodation in Florence.

After a day of adventure, treat yourself to an exquisite dinner at one of Florence's best restaurants.

Make sure to reserve a table at Ditta Artigianale, an iconic dining spot in Florence. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Trattoria Da Burde, a popular restaurant in Florence. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of Casa Toscana, a hidden gem nestled in Florence. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

Continue the enjoyment post-dinner at Bar 50 Rosso, a cherished local gathering spot renowned for its welcoming atmosphere. Similarly, Bitter Bar offers a vibrant space for indulging in well-crafted drinks and engaging conversation. You may also want to check out Archea Brewery. This bar is a favorite among both locals and visitors looking for a delightful evening out filled with laughter and fun.

Relax and recharge in preparation for another adventurous day in Italy!

On day 12 of your road trip in Italy, your travel plans include 1 stop at the most scenic, wondrous, and interesting places in the region. Florence are on today's agenda. In the evening, you’ll end up in Genoa, where you will stay for 1 night.

Enjoy all that Piazza Della Signoria has to offer. This is a spectacular public square you should not miss. Another must-see is Uffizi Gallery, an impressive art gallery in Florence.

When you’re ready for the next sight, head to Ponte Vecchio. From there, take a leisurely stroll to Cathedral Of Santa Maria Del Fiore, another of the city’s top-rated attractions. We recommend continuing your self-guided tour at Giotto's Bell Tower, a history-steeped place of interest in the city.

After soaking up all the sights on today's itinerary, you'll be ready to head to your accommodation in Genoa. Genoa offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Genoa. Enjoy a relaxing evening as you savor delicious local cuisine.

Start your culinary exploration in Genoa by securing a reservation at San Giorgio. This renowned restaurant holds 1 Michelin star and offers an exceptional menu of modern and ligurian cuisine. For another dining delight, visit The Cook, celebrated for its delectable modern menu. This acclaimed 1-star Michelin-recipient consistently leaves guests satisfied, making it a must-visit during your holiday. Looking for a different experience? Discover Il Marin, a top local spot known for its tantalizing seafood and contemporary menu. With a 1-star Michelin recognition, it guarantees an exceptional dining adventure.

Keep the excitement of the evening going by visiting a bar or two. Scurreria Beer & Bagel is an excellent place to start. You could also check out La Lepre, offering a different kind of charm. A last recommendation for the day is Bar Pisacane Iii. This bar promises an enjoyable experience with tasty drinks and a vibrant setting.

Relax and look forward to more memorable moments to come!

Your itinerary for day 13 of your road trip in Italy includes 1 stop and features some of the highlights of Genoa. At the end of the day, enjoy the comforts of a top-rated hotel in Pisa, where you'll spend 1 night.

Make a stop at Piazza De Ferrari. This notable public square is a must-visit for travelers looking for a unique holiday experience. Make your way to Doge's Palace located in Genoa for another exciting encounter.

Next, immerse yourself in the setting of Genoa Cathedral. Its culturally significant features will captivate you. After the church, continue your tour of the city with a visit to Aquarium Of Genoa. Visitors usually appreciate the visually striking features of this aquarium.

When you’re done exploring for the day, you’ll drive to your hotel in Pisa. Check in and relax before you head out to tour the city.

Indulge in a memorable dining experience at one of Pisa's most popular restaurants, and connect with friendly locals for a true cultural experience.

Treat yourself to a delightful dinner at Ristorante Capodimonte Pisa, highly recommended for tonight's dining. Or, if you're feeling adventurous, why not try La Locanda Dei Pisani Doc Pisa? It's another excellent option with a diverse menu. Consider reserving a table at Baribaldi Pisa as well. Known for its consistent customer satisfaction, it’s an ideal pick for tonight in Pisa.

Cap off your dinner by heading to Bar Mocambo, ideal for a leisurely evening with a drink in hand. Tree is another bar that offers an enjoyable setting. Similarly, Chupiteria is also a popular place to go on a night out, perfect for relaxing and socializing.

Get a good night's sleep and look forward to another great day on the road in Italy!