Two-Week Italy Self-Drive Road Trip With Itinerary from Genoa traveling south to Florence, Viterbo, Naples, Rome, and Siena

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Photo of Sand beach in Camogli by Genoa, Italy.
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Description

Explore the best of Italy on a remarkable 15-day road trip! Combine exploration with relaxation on a self-drive tour featuring Genoa, Florence, Bologna, Viterbo, Caserta, San Leucio-complex, Naples, Amalfi, Ravello, Rome, Siena, and Pisa.

This perfectly planned road trip itinerary takes you through some of the best places to see in Italy. You will spend 2 nights in Genoa, 3 nights in Florence, 1 night in Viterbo, 3 nights in Naples, 4 nights in Rome, and 1 night in Siena. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Italy. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have you covered.

Upon arriving in Genoa, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Italy on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Italy. Trevi Fountain and Colosseum are just a couple of the bucket-list attractions that await your discovery.

As you hit the open road and drive through Genoa, Florence, Bologna, Viterbo, Caserta, San Leucio-complex, Naples, Amalfi, Ravello, Rome, Siena, and Pisa, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Italy. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Italy.

Throughout your road trip in Italy, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Italy.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodations, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in Italy fill up quickly, so book your spot early. Select a date and start planning your road trip in Italy today!

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Driver’s age is 30 - 65
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Pick-up: 10:00
Drop-off: 10:00

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Day 1

Day 1

  • Genoa - Arrival day
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  • piazza De Ferrari
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Welcome to Genoa, the perfect starting point for your road trip in Italy! Pick up your rental car and let the adventure begin. You will spend 1 night discovering what to see in Genoa before embarking on the next leg of your journey.

Genoa is a beautiful city with plenty to discover. Taking a stroll in the city center is a great alternative. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

As afternoon approaches, head to your chosen hotel in Genoa. Check-in typically starts around 2 to 4 PM at hotels in Italy. We recommend staying at a central location for easy access to key areas in the city.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Genoa, it's often a good idea to reserve a table in advance.

Raise a toast to the start of your 15-day road trip in Italy!

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Day 2

Day 2

  • Genoa
  • Florence
  • More

Drive 263 km, 3 hours 34 min

  • Palazzo Bianco
  • Via Garibaldi
  • Aquarium of Genoa
  • porto antico
  • More

Your itinerary for day 2 of your road trip in Italy includes 1 stop and features some of the highlights of Genoa. At the end of the day, enjoy the comforts of a top-rated hotel in Florence, where you'll spend 3 nights.

When you’re done exploring for the day, you’ll drive to your hotel in Florence. Check in and relax before you head out to tour the city.

Indulge in a memorable dining experience at one of Florence's most popular restaurants, and connect with friendly locals for a true cultural experience.

Celebrate another amazing day of your road trip adventure in Italy!

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Day 3

Day 3

  • Florence
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Drive 237 km, 3 hours 33 min

  • Piazza Maggiore
  • Two Towers
  • Piazza Santo Stefano
  • Basilica of Santa Croce in Florence
  • More

Wake up to day 3 of your road trip in Italy. On this day, you’ll embark on an exciting expedition discovering the enchanting sights and activities of Bologna and Florence. With 2 nights to stay in Florence, we encourage you to seize the day and discover the unexplored beauty of the city’s surroundings!

When you’re done exploring for the day, you’ll return to Florence and your accommodation.

Florence is a place where the culinary landscape is as diverse as its attractions. So before the day ends, treat your palate to a taste of local cuisine at one of the best restaurants in Florence.

Get a good night's sleep and look forward to another great day on the road in Italy!

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Day 4

Day 4

  • Florence
  • More

Drive 1 km, 23 min

  • Palazzo Pitti
  • Ponte Vecchio
  • Uffizi Gallery
  • piazza della Signoria
  • More

You’ll stay in Florence for 1 night.

Throughout the day, make sure to take breaks to appreciate the surroundings.

Don’t forget to check out all the popular tours and experiences you can add to your travel plans in Italy. You can explore and select activities under each day of your itinerary.

After a day of adventure, treat yourself to an exquisite dinner at one of Florence's best restaurants.

Celebrate another amazing day of your road trip adventure in Italy!

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Day 5

Day 5

  • Florence
  • Viterbo
  • More

Drive 218 km, 3 hours 8 min

  • Cathedral of Santa Maria del Fiore
  • Central Market
  • Galleria dell'Accademia
  • David
  • piazzale Michelangelo
  • More

Experience an unparalleled adventure on day 5 of your road trip in Italy. This exciting part of your journey invites you to discover the renowned landmarks in 1 place, which are Florence. At the end of the day, you will retreat to the hotel of your choice in Viterbo, where will spend 1 night.

After soaking up all the sights on today's itinerary, you'll be ready to head to your accommodation in Viterbo. Viterbo offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

Viterbo is a place where the culinary landscape is as diverse as its attractions. So before the day ends, treat your palate to a taste of local cuisine at one of the best restaurants in Viterbo.

Take some time to reflect on your day and savor another beautiful night in Italy.

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Day 6

Day 6

  • Viterbo
  • Naples
  • More

Drive 321 km, 3 hours 50 min

  • Fontana Margherita
  • Giardini Reali - Parco Reggia di Caserta
  • Fountain of Ceres
  • Palace of Caserta
  • More

On day 6 of your exciting self-drive vacation in Italy, you’ll soak in the magnificence of 2 destinations, including Caserta and San Leucio-complex. When you’re not sightseeing, take time to relax at your chosen hotel in Naples, where you’ll be staying for 3 nights.

Throughout the day, make sure to take breaks to appreciate the surroundings.

At the end of the day, you will drive to Naples, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Naples. Enjoy a relaxing evening as you savor delicious local cuisine.

Get a good night's sleep and look forward to another great day on the road in Italy!

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Day 7

Day 7

  • Naples
  • More

Drive 10 km, 1 hour 35 min

  • Ovo Castle
  • piazza del Plebiscito
  • Castel Nuovo
  • Castel Sant'Elmo
  • More

You have 2 nights left in Naples. Take the opportunity to experience more of the best attractions and activities in the city.

Don’t forget to check out all the popular tours and experiences you can add to your travel plans in Italy. You can explore and select activities under each day of your itinerary.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Naples, it's often a good idea to reserve a table in advance.

Raise your glass and celebrate another amazing day of your road trip in Italy!

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Day 8

Day 8

  • Naples
  • More

Drive 130 km, 3 hours 27 min

  • Naples National Archaeological Museum
  • Cappella Sansevero
  • Amalfi Coast
  • Villa Rufolo
  • More

Greet day 8 of your road trip in Italy with a smile and start your day with a hearty breakfast. You have 1 night to stay in Naples, so get ready to make the most of your time in the region. On the agenda for this day, you’ll find only the best things to see and do in Naples, Amalfi, and Ravello.

When you’re done exploring the area’s best attractions, you’ll drive back to your accommodation in Naples.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Naples. Enjoy a relaxing evening as you savor delicious local cuisine.

As the day draws to a close, take a moment to unwind and prepare for the next exciting chapter of your road trip in Italy.

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Day 9

Day 9

  • Naples
  • Rome
  • More

Drive 240 km, 3 hours 17 min

  • Vatican Museums
  • Sistine Chapel
  • St Peter's Basilica
  • Saint Peter's Square
  • More

Dive into day 9 of your remarkable road trip in Italy. Today you'll explore 1 destination, including Vatican City. At the end of the day, you’ll unwind at one of the finest accommodations in Rome, where you'll spend 4 nights.

When you’re done exploring for the day, you’ll drive to your hotel in Rome. Check in and relax before you head out to tour the city.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Rome, it's often a good idea to reserve a table in advance.

Relax and recharge in preparation for another adventurous day in Italy!

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Day 10

Day 10

  • Rome
  • More

Drive 5 km, 54 min

  • Castel Sant'Angelo
  • Piazza Navona
  • Pantheon
  • Campo de' Fiori
  • More

Day 10 offers an itinerary packed with the best things to see in Genoa. You’ll stay in Rome for 3 nights more, offering you enough time to explore at a relaxed pace.

Don’t forget to check out all the popular tours and experiences you can add to your travel plans in Italy. You can explore and select activities under each day of your itinerary.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Rome. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Relax and recharge in preparation for another adventurous day in Italy!

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Day 11

Day 11

  • Rome
  • More

Drive 7 km, 57 min

  • Altare della Patria
  • Roman Forum
  • Colosseum
  • Archbasilica of St. John Lateran
  • More

Don’t forget to check out all the popular tours and experiences you can add to your travel plans in Italy. You can explore and select activities under each day of your itinerary.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Rome. Enjoy a relaxing evening as you savor delicious local cuisine.

Savor another day of unforgettable experiences in Italy!

Read more
Day 12

Day 12

  • Rome
  • More

Drive 9 km, 1 hour 8 min

  • Basilica di Santa Maria Maggiore
  • piazza del Popolo
  • Trevi Fountain
  • largo di Torre Argentina
  • More

You’ll stay in Rome for 1 night.

Don’t forget to check out all the popular tours and experiences you can add to your travel plans in Italy. You can explore and select activities under each day of your itinerary.

Rome is a place where the culinary landscape is as diverse as its attractions. So before the day ends, treat your palate to a taste of local cuisine at one of the best restaurants in Rome.

Take some time to reflect on your day and savor another beautiful night in Italy.

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Day 13

Day 13

  • Rome
  • Siena
  • More

Drive 245 km, 3 hours 30 min

  • Circus Maximus
  • Piazza di Spagna
  • Spanish Steps
  • Villa Borghese
  • More

On day 13 of your road trip in Italy, your travel plans include 1 stop at the most scenic, wondrous, and interesting places in the region. Rome are on today's agenda. In the evening, you’ll end up in Siena, where you will stay for 1 night.

After soaking up all the sights on today's itinerary, you'll be ready to head to your accommodation in Siena. Siena offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Siena. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Savor another day of unforgettable experiences in Italy!

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Day 14

Day 14

  • Siena
  • Genoa
  • More

Drive 286 km, 3 hours 57 min

  • piazza del Campo
  • Opera delle Metropolitana
  • Siena Cathedral
  • Cittadella Nuova
  • More

Your itinerary for day 14 of your road trip in Italy includes 2 stops and features some of the highlights of Siena and Pisa. At the end of the day, enjoy the comforts of a top-rated hotel in Genoa, where you'll spend 1 night.

At the end of the day, you will drive to Genoa, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

After a day of adventure, treat yourself to an exquisite dinner at one of Genoa's best restaurants.

Relax and look forward to more memorable moments to come!

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Day 15

Day 15

  • Genoa - Departure day
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  • Piazza Corvetto
  • More

Day 15 of your road trip in Italy is your departure day. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

Secure the perfect souvenirs for your family and friends back home or buy yourself a remembrance of your amazing vacation.

Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Italy!

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How it works

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Shortly after booking, you’ll receive your full itinerary, including schedules, locations, and everything you need for a stress-free trip.
Personalize your itinerary
Each package includes a professionally crafted itinerary you can tailor to your travel style. A dedicated travel expert will make sure every detail fits your needs perfectly.
Easily make changes
Need to update plans? No problem. Whether before your trip or mid-journey, we’re just seconds away to help with quick adjustments.
Enjoy seamless planning
With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.
Explore with confidence
From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.
Secure your spot
Confirm your package instantly and lock in the best rate with secure payment and guaranteed availability.
Get instant confirmation
Shortly after booking, you’ll receive your full itinerary, including schedules, locations, and everything you need for a stress-free trip.
Personalize your itinerary
Each package includes a professionally crafted itinerary you can tailor to your travel style. A dedicated travel expert will make sure every detail fits your needs perfectly.
Easily make changes
Need to update plans? No problem. Whether before your trip or mid-journey, we’re just seconds away to help with quick adjustments.
Enjoy seamless planning
With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.
Explore with confidence
From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.

We guarantee

Your trip is protected, personalized, and priced right. No surprises, no stress.

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