Two-Week Italy Self-Drive Road Trip With Itinerary from Genoa traveling south to Florence, Viterbo, Naples, Rome, and Siena

Your itinerary for day 2 of your road trip in Italy includes 1 stop and features some of the highlights of Genoa. At the end of the day, enjoy the comforts of a top-rated hotel in Florence, where you'll spend 3 nights.

Look forward to a unique sightseeing adventure at the locally appreciated Palazzo Bianco and allow yourself time to explore. Just a short distance away you'll find your next stop, Via Garibaldi, a romantic street that draws visitors from far and near.

Continue your journey to Aquarium Of Genoa, one of the city’s most spectacular spots that you shouldn’t miss. Another great site to visit is the notable Porto Antico.

When you’re done exploring for the day, you’ll drive to your hotel in Florence. Check in and relax before you head out to tour the city.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Florence. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Experience a harmony of flavors at Enoteca Pinchiorri in Florence by securing a reservation in advance. Known for its 3-star Michelin status, Enoteca Pinchiorri offers a delightful variety of dishes highlighting its delicious italian contemporary menu. If you're seeking an alternative culinary experience, be sure to explore Santa Elisabetta, a highly recommended restaurant known for its enticing creative and mediterranean cuisine. This popular 2-star Michelin-awarded venue consistently exceeds expectations, ensuring a memorable holiday experience. Ready for another culinary adventure? Indulge your senses at Gucci Osteria da Massimo Bottura, a highly acclaimed restaurant celebrated for its exceptional italian contemporary and international menu.

Extend your evening after a delightful meal by visiting Manifattura, which offers the perfect atmosphere for a night out. Moreover, Se·sto On Arno Rooftop Bar is another popular option for a drink or two. Likewise, Il Vinile also provides a great ambiance for reminiscing about the day and raising a toast to your vacation.

As the day draws to a close, take a moment to unwind and prepare for the next exciting chapter of your road trip in Italy.

On day 3 of your road trip in Italy, you’ll start and end your day in Florence, but spend the day exploring what’s beyond the city. Since you still have 2 nights to spend in Florence, there’s no need to rush. Experience Bologna and Florence to the fullest today with this curated day itinerary.

Make a stop at Basilica Of Santa Croce In Florence. This captivating church is a must-visit for travelers looking for a unique holiday experience.

Once you're ready to continue your road trip, it's time to buckle up and drive, eagerly anticipating your arrival in Bologna. This drive usually takes around 1 hour 29 min, without any stops or traffic disruptions.

Savor the day by heading to Piazza Maggiore, an astonishing public square that draws visitors from near and far. When you're done, continue to Two Towers, where you can soak in the culturally significant surroundings.

Next, explore Piazza Santo Stefano, yet another often recommended place to see in the area.

When you’re done exploring for the day, you’ll return to Florence and your accommodation.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Florence. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Treat yourself to a delicious dinner at Ditta Artigianale, an excellent option for tonight's dining. Looking for something different? Trattoria Da Burde offers a tantalizing alternative with its diverse menu. And don’t miss Casa Toscana. Known for great service, it’s a fantastic choice for tonight in Florence.

After enjoying a delightful dinner, why not delve into the vibrant local bar scene? You might want to spend the evening at Bar 50 Rosso, a well-loved spot among locals and tourists. Or, head to Bitter Bar. This bar boasts a welcoming environment that is perfect for winding down. You could also continue your night at Archea Brewery, another top-rated place in the area.

Head back to your accommodation in Florence and get some rest to prepare for another magical day of your road trip in Italy.

Day 4 offers an itinerary packed with the best things to see in Genoa. You’ll stay in Florence for 1 night more, offering you enough time to explore at a relaxed pace.

Florence is brimming with adventures.

Pitti Palace brings Florence's character to life. This visually striking palace is a highlight of any visit in the city. Then, enjoy Ponte Vecchio, another history-steeped attraction that never fails to captivate visitors. Next, head over to Uffizi Gallery, one of the city’s most top-rated attractions, known for its romantic features.

If you’re looking for more, spend time soaking in the atmosphere of Piazza Della Signoria. This history-steeped public square is frequented by locals and tourists alike. To complete your memorable day, make sure to take a stroll around the area.

Don’t forget to check out all the popular tours and experiences you can add to your travel plans in Italy. You can explore and select activities under each day of your itinerary.

After a day of adventure, treat yourself to an exquisite dinner at one of Florence's best restaurants.

Treat yourself to a wonderful meal at Ristorante Buca Mario, a top-rated dining spot in Florence. If you're in the mood for something new, try Agricola Toscana, another premier location with a delectable menu. You might also want to book a table at Eataly Firenze. Known for its consistently satisfied patrons, it’s a perfect choice to elevate your evening in Florence.

Explore the vibrant nightlife at Gosh* after your meal, a hub for lively evenings and memorable moments. Or, head to Antico Caffè Del Moro - Art Bar Firenze for a great selection of flavorful drinks and a charming setting. Furthermore, Quelo Bar is perfect for those looking to extend their night with a touch of local flavor.

Celebrate another amazing day of your road trip adventure in Italy!

On day 5 of your road trip in Italy, your travel plans include 1 stop at the most scenic, wondrous, and interesting places in the region. Florence are on today's agenda. In the evening, you’ll end up in Viterbo, where you will stay for 1 night.

Cathedral Of Santa Maria Del Fiore is perfect for a self-paced visit during the day. This history-steeped church is sure to impress. Next on your list is Central Market, another must-visit landmark and captivating food market renowned for its instagrammable features.

While exploring and sightseeing, take time to savor the culture of Florence by sampling some local delicacies. When you’re ready for more sightseeing, head to Galleria Dell'accademia. This eye-catching art gallery is an essential place to visit for anyone looking for the full Florence experience. We also recommend visiting David, an interesting statue. Nearby, you'll also find Piazzale Michelangelo, ready to add charm to your journey.

After soaking up all the sights on today's itinerary, you'll be ready to head to your accommodation in Viterbo. Viterbo offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

Viterbo is a place where the culinary landscape is as diverse as its attractions. So before the day ends, treat your palate to a taste of local cuisine at one of the best restaurants in Viterbo.

As the sun sets, rest up and recharge for the next leg of your road trip in Italy.

On day 6 of your exciting self-drive vacation in Italy, you’ll soak in the magnificence of 2 destinations, including Caserta and San Leucio-complex. When you’re not sightseeing, take time to relax at your chosen hotel in Naples, where you’ll be staying for 3 nights.

Fasten your seatbelt and make your way to your next stop — Caserta, home to many well-known sights in the region. Keep in mind that your travel time from Viterbo to Caserta may take around 2 hours 46 min without traffic disruptions. Upon arrival in Caserta, we highly recommend checking out some of the top attractions.

Next, make your way to Giardini Reali - Parco Reggia Di Caserta, another highlight in Caserta. When you’re done exploring the park, continue to Palace Of Caserta, an UNESCO world heritage-designated palace.

At the end of the day, you will drive to Naples, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Naples, it's often a good idea to reserve a table in advance.

Discover the culinary delights of Naples by securing a reservation at Veritas. Esteemed for its 1-star Guide Michelin recognition, this restaurant offers a remarkable selection of campanian and contemporary cuisine. For an alternative dining experience, try Il Comandante, renowned for its delicious creative and mediterranean dishes. This esteemed 1-star Michelin-recipient consistently impresses guests, making it a must-visit spot during your holiday. Craving more culinary excitement? Head to ARIA, a highly recommended local eatery celebrated for its mouthwatering contemporary and modern menu. With its 1-star Michelin recognition, it offers an unforgettable dining adventure.

After your meal, keep the night alive at a bar like Happening Cocktail Bar, known for its lively atmosphere. Shanti Art Musik Bar is another top recommendation that provides the perfect setting with well-crafted drinks and a welcoming ambiance. Similarly, Gran Caffè Gambrinus offers an excellent atmosphere for those looking to amp up the evening.

Get a good night's sleep and look forward to another great day on the road in Italy!

On day 7 of your road trip, you will have an entire day to discover what to see in Naples. You’ll stay in Naples for 2 nights.

Whatever your travel style is, Ovo Castle is an essential stop in Naples. This interesting castle provides an insightful glimpse into the city's identity. Next, discover Piazza Del Plebiscito, a history-steeped public square, promising a delightful encounter.

Continue your sightseeing with a visit to Castel Nuovo, a popular castle. When you’re done, don’t forget to make a stop at the captivating Castel Sant'elmo.

Don’t forget to check out all the popular tours and experiences you can add to your travel plans in Italy. You can explore and select activities under each day of your itinerary.

Naples is a place where the culinary landscape is as diverse as its attractions. So before the day ends, treat your palate to a taste of local cuisine at one of the best restaurants in Naples.

Make sure to reserve a table at Antica Pizzeria Di Matteo, an iconic dining spot in Naples. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Mercure Napoli Centro Angioino, a popular restaurant in Naples. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of La Lazzara Trattoria e Pizzeria, a hidden gem nestled in Naples. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

If you’re not ready to end the night just yet, Archivio Storico - Cocktail Bar & Wonderfood offers a perfect venue to relax and savor a drink. Similarly, Archeobar is well-suited for those looking to unwind in a social setting. Babette Pub is another excellent spot to enjoy a nightcap after a delightful meal.

Savor another day of unforgettable experiences in Italy!

Greet day 8 of your road trip in Italy with a smile and start your day with a hearty breakfast. You have 1 night to stay in Naples, so get ready to make the most of your time in the region. On the agenda for this day, you’ll find only the best things to see and do in Naples, Amalfi, and Ravello.

Naples National Archaeological Museum is an ideal stop early in the day. This captivating museum is a must-visit in the city. When you’re ready for your next discovery, continue to Cappella Sansevero, which may be one of the most photogenic places you will experience today.

Set your GPS to Amalfi and hit the road. Expect a journey of approximately 1 hour 28 min without stops. Soak in the beautiful landscapes as you drive and look forward to exploring your next destination. Amalfi beckons with new experiences!

For a more meaningful self-guided tour of the city's best attractions, visit Amalfi Coast, an astonishing coast that is sure to impress. Take in the surroundings and enjoy the freedom of exploring at your own pace before you continue your journey.

Once you're ready to continue your road trip, it's time to buckle up and drive, eagerly anticipating your arrival in Ravello. This drive usually takes around 19 min, without any stops or traffic disruptions.

When you're ready for some sights, head to Villa Rufolo, a well-known historical landmark in Ravello. Explore its romantic features at your own pace before you continue your journey.

When you’re done exploring the area’s best attractions, you’ll drive back to your accommodation in Naples.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Naples. Enjoy a relaxing evening as you savor delicious local cuisine.

Enjoy a lovely meal at Opera Restaurant, a top-rated place to have dinner tonight. Alternatively, if your taste buds call for something different, Trattoria San Ferdinando is another top choice with a popular menu. You could also check for a table at Anonymous Trattoria Gourmet. As an establishment that consistently gains high praises from customers, it’s an ideal choice in Naples tonight.

Keep the excitement of the evening going by visiting a bar or two. Gran Caffè Cimmino is an excellent place to start. You could also check out Flanagan's Bar, offering a different kind of charm. A last recommendation for the day is Bar Napoli. This bar promises an enjoyable experience with tasty drinks and a vibrant setting.

As the sun sets, rest up and recharge for the next leg of your road trip in Italy.

Experience an unparalleled adventure on day 9 of your road trip in Italy. This exciting part of your journey invites you to discover the renowned landmarks in 1 place, which are Vatican City. At the end of the day, you will retreat to the hotel of your choice in Rome, where will spend 4 nights.

It’s time to gear up for the next part of your road trip adventure. Set course for Vatican City! Under favorable conditions, your drive to Vatican City may take around 2 hours 42 min. Upon your arrival in Vatican City, you’ll be greeted with the opportunity to do some sightseeing and exploring.

Next, continue your sightseeing at Sistine Chapel, an extraordinary chapel.

Make sure to also explore Saint Peter's Square, a captivating square.

When you’re done exploring for the day, you’ll drive to your hotel in Rome. Check in and relax before you head out to tour the city.

Indulge in a memorable dining experience at one of Rome's most popular restaurants, and connect with friendly locals for a true cultural experience.

Get ready for an unforgettable culinary journey in Rome by reserving a table at La Pergola. Renowned as a 3-star Michelin restaurant, it offers an exceptional mediterranean and contemporary menu. For a different taste experience, head to Il Pagliaccio, recognized for its delicious creative and innovative dishes. This 2-star Michelin restaurant consistently impresses guests, ensuring a memorable addition to your holiday. Looking for another option? Make sure to visit Enoteca La Torre, a local favorite known for its delightful mediterranean and creative cuisine in Rome. Nestled in the heart of the city, this restaurant with 2 Michelin star is an ideal choice for mediterranean and creative foodies seeking culinary excellence.

If you’re not ready to end the night just yet, La Botticella Of Poggi Giovanni offers a perfect venue to relax and savor a drink. Similarly, Almalu Trastevere is well-suited for those looking to unwind in a social setting. Bar Viminale Di Pepi Maurilio is another excellent spot to enjoy a nightcap after a delightful meal.

Celebrate another amazing day of your road trip adventure in Italy!

Day 10 of your road trip across Italy promises a magnificent time exploring what to see in Rome. You have 3 nights left in Rome. Take the opportunity to experience more of the best attractions and activities in the city.

Castel Sant'angelo is an ideal stop early in the day. This spectacular castle is a must-visit in the city. When you’re ready for your next discovery, continue to Piazza Navona, which may be one of the most grand places you will experience today.

One of the best things about exploring Rome on a self-guided tour is that you set the pace. There’s plenty of time for detours and discovering hidden gems. When you’re ready for your next stop, make your way to Pantheon, a timeless monument in the city. If you’re up for more discoveries, don’t forget to reserve some time for Campo De' Fiori.

Don’t forget to check out all the popular tours and experiences you can add to your travel plans in Italy. You can explore and select activities under each day of your itinerary.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Rome, it's often a good idea to reserve a table in advance.

Treat yourself to a delightful dinner at RomAntica, highly recommended for tonight's dining. Or, if you're feeling adventurous, why not try Coso Ristorante? It's another excellent option with a diverse menu. Consider reserving a table at DEROMA - Farine Romane as well. Known for its consistent customer satisfaction, it’s an ideal pick for tonight in Rome.

Following your dinner, dive into the local bar culture at Sant' Eustachio Caffè. Enjoy this evening's relaxed ambiance with delightful drinks. Alternatively, go to Yellowsquare Rome, the perfect place for those looking to experience the best of the nightlife. Similarly, Caffè Portofino provides excellent drinks and a great atmosphere, ensuring a memorable night out.

Say good night to Rome and look forward to another great day of your road trip in Italy!

Day 11 of your road trip will take you to the best attractions Rome has to offer. Cherish the 2 nights you have left in the city and use the provided itinerary to discover what to see in Rome.

Make a stop at Altare Della Patria. This popular monument is a must-visit for travelers looking for a unique holiday experience. Make your way to Roman Forum located in Rome for another exciting encounter.

Next, immerse yourself in the setting of Colosseum. Its culturally significant features will captivate you. After the archeological site, continue your tour of the city with a visit to Archbasilica Of St. John Lateran. Visitors usually appreciate the historic features of this church.

Don’t forget to check out all the popular tours and experiences you can add to your travel plans in Italy. You can explore and select activities under each day of your itinerary.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Rome. Enjoy a relaxing evening as you savor delicious local cuisine.

Have a fantastic dining experience at Hotel de Russie, a highly recommended choice for tonight's dinner. If you're looking to mix things up, La Taverna Italiana offers an enticing alternative with its varied menu. Additionally, The Parrot Bar is worth considering. Renowned for satisfying diners, it’s an ideal option for tonight in Rome.

To truly maximize your evening out, consider visiting The Apartment Bar Roma after dinner. This bar is known for offering some of the best drinks and vibes in the city. Alternatively, head to Hotel Hassler Roma, another bar with an inviting ambiance.

Relax and look forward to more memorable moments to come!

Day 12 offers an itinerary packed with the best things to see in Genoa. You’ll stay in Rome for 1 night more, offering you enough time to explore at a relaxed pace.

Look forward to a unique sightseeing adventure at the locally renowned Basilica Di Santa Maria Maggiore and allow yourself time to explore. Just a short distance away you'll find your next stop, Piazza Del Popolo, a romantic public square that draws visitors from far and near.

Continue your journey to Trevi Fountain, one of the city’s most iconic spots that you shouldn’t miss. Another great site to visit is the locally renowned Largo Di Torre Argentina.

Don’t forget to check out all the popular tours and experiences you can add to your travel plans in Italy. You can explore and select activities under each day of your itinerary.

Indulge in a memorable dining experience at one of Rome's most popular restaurants, and connect with friendly locals for a true cultural experience.

Treat yourself to a delicious dinner at Sofitel Roma Villa Borghese, an excellent option for tonight's dining. Looking for something different? Centro offers a tantalizing alternative with its diverse menu. And don’t miss Ristorante Tema. Known for great service, it’s a fantastic choice for tonight in Rome.

As the sun sets, rest up and recharge for the next leg of your road trip in Italy.

Dive into day 13 of your remarkable road trip in Italy. Today you'll explore 1 destination, including Rome. At the end of the day, you’ll unwind at one of the finest accommodations in Siena, where you'll spend 1 night.

Experience Circus Maximus, a captivating archeological site in the city. Then, head to Piazza Di Spagna and soak in the ambiance of this awe-inspiring public square.

There are many interesting places to see in Rome, and when you are ready for more, go to Spanish Steps. This is one of the city’s most widely recognized enchanting spots of interest. After exploring the public square, visit the extraordinary Villa Borghese.

After soaking up all the sights on today's itinerary, you'll be ready to head to your accommodation in Siena. Siena offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Siena. Enjoy a relaxing evening as you savor delicious local cuisine.

Enjoy a lovely meal at Enoteca I Terzi, a top-rated place to have dinner tonight. Alternatively, if your taste buds call for something different, Ristorante Tar-Tufo is another top choice with a popular menu. You could also check for a table at Antica Trattoria Papei. As an establishment that consistently gains high praises from customers, it’s an ideal choice in Siena tonight.

Explore the vibrant nightlife at Meet Life Cafè after your meal, a hub for lively evenings and memorable moments. Or, head to Maudit Pub for a great selection of flavorful drinks and a charming setting. Furthermore, Bar Impero Siena is perfect for those looking to extend their night with a touch of local flavor.

Say good night to Siena and look forward to another great day of your road trip in Italy!

Your itinerary for day 14 of your road trip in Italy includes 2 stops and features some of the highlights of Siena and Pisa. At the end of the day, enjoy the comforts of a top-rated hotel in Genoa, where you'll spend 1 night.

Piazza Del Campo leaves a lasting impression. This public square is one of the most famous places to visit in Siena. Next, head to Opera Delle Metropolitana, a locally appreciated museum, known for its breathtaking features.

In between the sights, don’t hesitate to take small detours to explore local stores and eateries. When you’re ready to continue your adventure, head to Siena Cathedral. This grand church is a highly recommended experience.

Embrace the thrill of the open road as you wave goodbye to Siena and set your GPS to Pisa. While on the road, immerse yourself in your favorite road trip tunes or sample the sounds from a local radio station. This car ride usually takes around 1 hour 43 min. Upon reaching Pisa, unwind, observe, and explore. The best things to do, see, and eat are waiting for you.

Spend your afternoon discovering Cittadella Nuova, an often recommended park known for its visually striking features.

At the end of the day, you will drive to Genoa, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

After a day of adventure, treat yourself to an exquisite dinner at one of Genoa's best restaurants.

Have a memorable dining experience in Genoa by booking a table at San Giorgio, a 1-star Michelin restaurant presenting an exceptional modern and ligurian menu. For a different culinary experience in Genoa, The Cook shines as one of the top destinations, known for its delicious modern cuisine. This 1-star Michelin-awardee consistently earns high praises, making it a must-visit addition to your holiday experience. If you're looking for an alternative, Il Marin is known as a top local spot in Genoa for its delicious seafood and contemporary cuisine. This 1-star Michelin awardee is a highly recommended choice for an unforgettable meal.

Head back to your accommodation in Genoa and get some rest to prepare for another magical day of your road trip in Italy.