Two-Week Italy Self-Drive Road Trip With Itinerary from Pisa traveling south to Perugia, Rome, Naples, Viterbo, and Florence

On day 2 of your exciting self-drive vacation in Italy, you’ll soak in the magnificence of 1 destination, including Pisa. When you’re not sightseeing, take time to relax at your chosen hotel in Perugia, where you’ll be staying for 1 night.

Leaning Tower Of Pisa leaves a lasting impression. This monument is one of the most wondrous places to visit in Pisa.

In between the sights, don’t hesitate to take small detours to explore local stores and eateries. When you’re ready to continue your adventure, head to Pisa Cathedral. This breathtaking church is a highly recommended experience. Nearby, you'll also find Piazza Del Duomo, Pisa and Campo Santo Visit these for an interesting touch to your journey.

At the end of the day, you will drive to Perugia, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Perugia. Enjoy a relaxing evening as you savor delicious local cuisine.

Savor the flavors at Ristorante Settimo Sigillo, a top pick for dinner tonight. Alternatively, Caffè Baglioni beckons with its unique menu offerings. Also, consider Bar Pellas. With its consistent customer satisfaction, it’s an excellent option for dining in Perugia tonight.

Cap off your dinner by heading to Tommi Bar, ideal for a leisurely evening with a drink in hand. Valentina is another bar that offers an enjoyable setting. Similarly, Caffe Dal Perugino is also a popular place to go on a night out, perfect for relaxing and socializing.

As the day draws to a close, take a moment to unwind and prepare for the next exciting chapter of your road trip in Italy.

Dive into day 3 of your remarkable road trip in Italy. Today you'll explore 1 destination, including Vatican City. At the end of the day, you’ll unwind at one of the finest accommodations in Rome, where you'll spend 5 nights.

Whether you decide to get entrance tickets for all attractions or you prefer admiring from a distance, amazing experiences await on this day in Vatican City.

Fasten your seatbelt and make your way to your next stop — Vatican City, home to many well-known sights in the region. Keep in mind that your travel time from Perugia to Vatican City may take around 2 hours 17 min without traffic disruptions. Upon arrival in Vatican City, we highly recommend checking out some of the top attractions.

For a more meaningful self-guided tour of the city's best attractions, visit Vatican Museums, an iconic art museum that is sure to impress. Take in the surroundings and enjoy the freedom of exploring at your own pace before you continue your journey.

When you’re ready, continue to Sistine Chapel, an astonishing chapel beloved by locals and tourists alike. Don't miss out on St. Peter's Basilica, another highlight of the area that promises a memorable visit.

When you’re done exploring for the day, you’ll drive to your hotel in Rome. Check in and relax before you head out to tour the city.

After a day of adventure, treat yourself to an exquisite dinner at one of Rome's best restaurants.

Experience a taste of local culinary excellence while in Rome by securing a table at La Pergola. An esteemed 3-star Michelin restaurant, it features an exceptional mediterranean and contemporary menu. For an alternative taste experience, visit Il Pagliaccio, famous for its scrumptious creative and innovative dishes. This 2-star Michelin venue consistently impresses guests, making it a standout addition to your holiday plans. Looking for another choice? Discover Enoteca La Torre, a local favorite celebrated for its exquisite mediterranean and creative cuisine in Rome. Located in the heart of the city, this 2-star Michelin restaurant is an ideal pick for mediterranean and creative cuisine lovers seeking top-notch culinary experiences.

Continue your lively evening at La Botticella Of Poggi Giovanni, a perfect place for winding down or revving up the night, depending on which mood you’re in. Almalu Trastevere is another excellent bar that offers a great selection of drinks to suit any mood. If you prefer to go somewhere else, Bar Viminale Di Pepi Maurilio ensures a night out tailored to your taste.

Raise your glass and celebrate another amazing day of your road trip in Italy!

Day 4 offers an itinerary packed with the best things to see in Pisa. You’ll stay in Rome for 4 nights more, offering you enough time to explore at a relaxed pace.

Experience Villa Borghese, a widely recognized park in the city. Then, head to Piazza Del Popolo and soak in the ambiance of this romantic public square.

There are many interesting places to see in Rome, and when you are ready for more, go to Spanish Steps. This is one of the city’s most astonishing history-steeped spots of interest. After exploring the public square, visit the timeless Piazza Di Spagna. Not far away, you'll also find Trevi Fountain. This monument is a history-steeped highlight in Rome.

Don’t forget to check out all the popular tours and experiences you can add to your travel plans in Italy. You can explore and select activities under each day of your itinerary.

After a day of adventure, treat yourself to an exquisite dinner at one of Rome's best restaurants.

Enjoy a lovely meal at RomAntica, a top-rated place to have dinner tonight. Alternatively, if your taste buds call for something different, Coso Ristorante is another top choice with a popular menu. You could also check for a table at DEROMA - Farine Romane. As an establishment that consistently gains high praises from customers, it’s an ideal choice in Rome tonight.

After enjoying a delightful dinner, why not delve into the vibrant local bar scene? You might want to spend the evening at Sant' Eustachio Caffè, a well-loved spot among locals and tourists. Or, head to Yellowsquare Rome. This bar boasts a welcoming environment that is perfect for winding down. You could also continue your night at Caffè Portofino, another top-rated place in the area.

As the sun sets, rest up and recharge for the next leg of your road trip in Italy.

Day 5 of your road trip across Italy promises a magnificent time exploring what to see in Rome. You have 3 nights left in Rome. Take the opportunity to experience more of the best attractions and activities in the city.

Make a stop at Colosseum. This timeless archeological site is a must-visit for travelers looking for a unique holiday experience. Make your way to Roman Forum located in Rome for another exciting encounter.

Next, immerse yourself in the setting of Capitoline Hill. Its remarkable features will captivate you. After the public square, continue your tour of the city with a visit to Altare Della Patria. Visitors usually appreciate the breathtaking features of this monument. Next up is Basilica Di Santa Maria Maggiore, a highly recommended church.

Don’t forget to check out all the popular tours and experiences you can add to your travel plans in Italy. You can explore and select activities under each day of your itinerary.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Rome. Enjoy a relaxing evening as you savor delicious local cuisine.

Treat yourself to a delightful dinner at Hotel de Russie, highly recommended for tonight's dining. Or, if you're feeling adventurous, why not try La Taverna Italiana? It's another excellent option with a diverse menu. Consider reserving a table at The Parrot Bar as well. Known for its consistent customer satisfaction, it’s an ideal pick for tonight in Rome.

To truly maximize your evening out, consider visiting The Apartment Bar Roma after dinner. This bar is known for offering some of the best drinks and vibes in the city. Alternatively, head to Hotel Hassler Roma, another bar with an inviting ambiance.

Get a good night's sleep and look forward to another great day on the road in Italy!

Day 6 of your road trip will take you to the best attractions Rome has to offer. Cherish the 2 nights you have left in the city and use the provided itinerary to discover what to see in Rome.

Whatever your travel style is, Castel Sant'angelo is an essential stop in Rome. This astonishing castle provides an insightful glimpse into the city's identity. Next, discover Piazza Navona, a romantic public square, promising a delightful encounter.

Continue your sightseeing with a visit to Pantheon, a wondrous monument. When you’re done, don’t forget to make a stop at the locally renowned Largo Di Torre Argentina. Round off your day at Campo De' Fiori, another gem in Rome with romantic features to discover.

Don’t forget to check out all the popular tours and experiences you can add to your travel plans in Italy. You can explore and select activities under each day of your itinerary.

Rome is a place where the culinary landscape is as diverse as its attractions. So before the day ends, treat your palate to a taste of local cuisine at one of the best restaurants in Rome.

Dine in style at Sofitel Roma Villa Borghese, a top recommendation for dinner tonight. Or, for a change of pace, Centro boasts a menu that's sure to impress. Also, be sure to check out Ristorante Tema. Known as a local hotspot, it’s a great choice for tonight in Rome.

Savor another day of unforgettable experiences in Italy!

On day 7 of your road trip, you will have an entire day to discover what to see in Rome. You’ll stay in Rome for 1 night.

Rome is brimming with adventures.

Orange Garden is must-visit park and a great option for a daytime tour of the area. Continue your journey to Circus Maximus, a popular archeological site, located just a leisurely stroll away. Next, head to Archbasilica Of St. John Lateran, a breathtaking church, also available for your discovery today.

Each stop on today’s itinerary promises to leave you with lasting memories and a deeper appreciation for Rome. When you're ready, let your sightseeing route take you to the popular Auditorium Parco Della Musica. If you’re looking for more, Foro Italico is also a popular attraction that is worthwhile a visit.

Don’t forget to check out all the popular tours and experiences you can add to your travel plans in Italy. You can explore and select activities under each day of your itinerary.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Rome, it's often a good idea to reserve a table in advance.

Don’t miss out on dining at Ristorante Va. Do. , a top-rated dining destination in Rome. If you're in the mood to try something new, consider Giulia Restaurant, another top spot with a mouthwatering menu. You might also want to secure a reservation at L'Archeologia. With a reputation for consistently satisfying customers, it’s a perfect choice to enhance your stay in Rome this evening.

Celebrate another amazing day of your road trip adventure in Italy!

Experience an unparalleled adventure on day 8 of your road trip in Italy. This exciting part of your journey invites you to discover the renowned landmarks in 2 places, which are Caserta and Ottaviano. At the end of the day, you will retreat to the hotel of your choice in Naples, where will spend 3 nights.

Set your GPS to Caserta and hit the road. Expect a journey of approximately 2 hours 13 min without stops. Soak in the beautiful landscapes as you drive and look forward to exploring your next destination. Caserta beckons with new experiences!

One of our top recommendations for your sightseeing is Fontana Margherita. Then, head to Giardini Reali - Parco Reggia Di Caserta. This captivating park is a traveler-favorite in the city.

If you're keen to see more, continue to Palace Of Caserta. Feed your curiosity by learning something new about the palace.

After soaking in Caserta’s unique atmosphere, jump into the car with a full heart and drive in the direction of your next destination: Ottaviano. Expect your car journey to take a minimum of 53 min. When you arrive in Ottaviano, it's time to take a break from the road.

Set out on a self-guided sightseeing tour at Mount Vesuvius and explore the respected features.

After soaking up all the sights on today's itinerary, you'll be ready to head to your accommodation in Naples. Naples offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

Naples is a place where the culinary landscape is as diverse as its attractions. So before the day ends, treat your palate to a taste of local cuisine at one of the best restaurants in Naples.

Experience a harmony of flavors at Veritas in Naples by securing a reservation in advance. Known for its 1-star Michelin status, Veritas offers a delightful variety of dishes highlighting its delicious campanian and contemporary menu. If you're seeking an alternative culinary experience, be sure to explore Il Comandante, a highly recommended restaurant known for its enticing creative and mediterranean cuisine. This popular 1-star Michelin-awarded venue consistently exceeds expectations, ensuring a memorable holiday experience. Ready for another culinary adventure? Indulge your senses at ARIA, a highly acclaimed restaurant celebrated for its exceptional contemporary and modern menu.

Following your dinner, dive into the local bar culture at Happening Cocktail Bar. Enjoy this evening's relaxed ambiance with delightful drinks. Alternatively, go to Shanti Art Musik Bar, the perfect place for those looking to experience the best of the nightlife. Similarly, Gran Caffè Gambrinus provides excellent drinks and a great atmosphere, ensuring a memorable night out.

Relax and recharge in preparation for another adventurous day in Italy!

On day 9 of your road trip in Italy, you’ll start and end your day in Naples, but spend the day exploring what’s beyond the city. Since you still have 2 nights to spend in Naples, there’s no need to rush. Experience Ravello, Amalfi, and Pompei to the fullest today with this curated day itinerary.

Ravello is brimming with adventures.

It’s time to gear up for the next part of your road trip adventure. Under favorable conditions, your drive to Ravello may take around 1 hour 10 min. Upon your arrival in Ravello, you’ll be greeted with the opportunity to do some sightseeing and exploring.

Spend your afternoon discovering Villa Rufolo, a notable historical landmark known for its history-steeped features.

Amalfi’s wonders await as you prepare for another journey on the road, leaving the breathtaking surroundings of Ravello behind. This drive usually takes around 20 min. Amalfi welcomes you with a multitude of unique vacation experiences.

For a more meaningful self-guided tour of the village's best attractions, visit Amalfi Coast, a spectacular coast that is sure to impress. Take in the surroundings and enjoy the freedom of exploring at your own pace before you continue your journey.

Embrace the thrill of the open road as you wave goodbye to Amalfi and set your GPS to Pompei. While on the road, immerse yourself in your favorite road trip tunes or sample the sounds from a local radio station. This car ride usually takes around 1 hour 2 min. Upon reaching Pompei, unwind, observe, and explore. The best things to do, see, and eat are waiting for you.

Set out on a self-guided sightseeing tour at Amphitheatre Of Pompeii and explore the breathtaking features. Next, make your way to Teatro Grande, another highlight in Pompei. When you’re done exploring the archeological site, continue to Archaeological Park Of Pompeii, an UNESCO world heritage-listed archeological site.

When you’re done exploring for the day, you’ll return to Naples and your accommodation.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Naples. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Make sure to reserve a table at Antica Pizzeria Di Matteo, an iconic dining spot in Naples. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Mercure Napoli Centro Angioino, a popular restaurant in Naples. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of La Lazzara Trattoria e Pizzeria, a hidden gem nestled in Naples. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

After enjoying a fulfilling meal, continue your evening at Archivio Storico - Cocktail Bar & Wonderfood, ideal for those looking to unwind with a drink in a comfortable setting. Alternatively, Archeobar offers a welcoming atmosphere for easing into the nightlife. Similarly, Babette Pub provides an excellent environment for a relaxed and enjoyable evening.

Head back to your accommodation in Naples and get some rest to prepare for another magical day of your road trip in Italy.

Day 10 offers an itinerary packed with the best things to see in Pisa. You’ll stay in Naples for 1 night more, offering you enough time to explore at a relaxed pace.

Start your day at Castel Nuovo. This historic castle is a locally renowned place to see in Naples. Then, wander over to San Carlo Theatre. If respected sites excite you, this opera house will be right up your alley. Nearby, you’ll also find Castel Sant'elmo. This culturally significant castle is a favorite among visitors.

Naples offers plenty to explore, ensuring every moment of your visit is filled with excitement and discovery. If you're up for more, Piazza Del Plebiscito is a famous spot in the city that will captivate you with its unique charm. When you’re done at the public square, don’t forget to check out the culturally significant Ovo Castle. Take a moment to appreciate the fascinating details of this captivating castle.

Don’t forget to check out all the popular tours and experiences you can add to your travel plans in Italy. You can explore and select activities under each day of your itinerary.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Naples. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Enjoy a delicious meal at Opera Restaurant, a highly-rated dining destination in Naples. If you're eager to try something different, consider Trattoria San Ferdinando, another top spot with a tantalizing menu. You might also want to secure a reservation at Anonymous Trattoria Gourmet. With a reputation for consistently satisfying customers, it’s an excellent choice to enhance your stay in Naples this evening.

Let the evening flow smoothly from dinner to drinks at Gran Caffè Cimmino, a top-rated bar in the area. For other recommendations, Flanagan's Bar provides a perfect setting for rounding out your night with style and great drinks. Likewise, Bar Napoli offers a memorable night with diverse drink options and excellent service.

Relax and look forward to more memorable moments to come!

Your itinerary for day 11 of your road trip in Italy includes 2 stops and features some of the highlights of Naples and Tivoli. At the end of the day, enjoy the comforts of a top-rated hotel in Viterbo, where you'll spend 1 night.

Make a stop at Naples National Archaeological Museum. This locally renowned museum is a must-visit for travelers looking for a unique holiday experience. Make your way to Cappella Sansevero located in Naples for another exciting encounter.

When you’ve had your share of Naples, prepare for your next destination. Admire the views and listen to some good music as you drive in the direction of Tivoli. Your travel time is around 2 hours 15 min.

Enjoy sightseeing at your own pace and allow yourself time to explore the beautiful surroundings. Take your self-guided tour to Hadrian's Villa, an increasingly popular archeological site that everyone visiting Tivoli should see.

At the end of the day, you will drive to Viterbo, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Viterbo, it's often a good idea to reserve a table in advance.

Relax and look forward to more memorable moments to come!

On day 12 of your road trip in Italy, your travel plans include 1 stop at the most scenic, wondrous, and interesting places in the region. Orvieto are on today's agenda. In the evening, you’ll end up in Florence, where you will stay for 2 nights.

Continue your road trip and head to your next destination, Orvieto. This car ride takes around 53 min.

Spend your afternoon discovering Orvieto Cathedral, a captivating church known for its inviting features. Next, continue your sightseeing at Pozzo Della Cava, an intriguing cave.

If you're starting to feel hungry, this is a great time for a break at a nearby restaurant or cafe. When you're ready for more, stop by Orvieto Underground and uncover the details of this visually striking cave system.

Embrace the thrill of the open road as you wave goodbye to Viterbo and set your GPS to Orvieto. While on the road, immerse yourself in your favorite road trip tunes or sample the sounds from a local radio station. This car ride usually takes around 53 min. Upon reaching Orvieto, unwind, observe, and explore. The best things to do, see, and eat are waiting for you.

One of our top recommendations for your sightseeing is Well Of St. Patrick. Spend some time admiring the picture-perfect features of the monument before you continue to your next stop.

When you’re done exploring for the day, you’ll drive to your hotel in Florence. Check in and relax before you head out to tour the city.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Florence. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Enjoy an outstanding dining experience at Enoteca Pinchiorri, a 3-star Michelin restaurant offering an exceptional italian contemporary menu. Alternatively, if you're in the mood for something different, consider the nearby 2-star Michelin-awardee, Santa Elisabetta, known for its delicious creative and mediterranean cuisine. Another highly-recommended place to eat in Florence is Gucci Osteria da Massimo Bottura, a renowned restaurant with a 1-star Guide Michelin recognition and a delicious italian contemporary and international menu.

After enjoying a fulfilling meal, continue your evening at Manifattura, ideal for those looking to unwind with a drink in a comfortable setting. Alternatively, Se·sto On Arno Rooftop Bar offers a welcoming atmosphere for easing into the nightlife. Similarly, Il Vinile provides an excellent environment for a relaxed and enjoyable evening.

Savor another day of unforgettable experiences in Italy!

Day 13 of your road trip across Italy promises a magnificent time exploring what to see in Florence. You have 1 night left in Florence. Take the opportunity to experience more of the best attractions and activities in the city.

Visiting Ponte Vecchio is always a good idea. This globally renowned historical landmark is a place that is appreciated by travelers and locals alike. Next, immerse yourself in the picture-perfect wonders of Uffizi Gallery, a must-see art gallery in the city.

Consider stopping for a small bite to eat or a drink at a local eatery to keep your energy going. When you’re ready, continue your discovery with a visit to Piazza Della Signoria. This extraordinary public square offers an enriching experience. For a change of pace, head to Basilica Of Santa Croce In Florence, where you can take in heritage-rich features. Conclude your self-guided sightseeing tour with a visit to Piazzale Michelangelo These sights offer a fulfilling end to a perfect day.

Don’t forget to check out all the popular tours and experiences you can add to your travel plans in Italy. You can explore and select activities under each day of your itinerary.

Indulge in a memorable dining experience at one of Florence's most popular restaurants, and connect with friendly locals for a true cultural experience.

Savor the flavors at Ditta Artigianale, a top pick for dinner tonight. Alternatively, Trattoria Da Burde beckons with its unique menu offerings. Also, consider Casa Toscana. With its consistent customer satisfaction, it’s an excellent option for dining in Florence tonight.

Following your dinner, dive into the local bar culture at Bar 50 Rosso. Enjoy this evening's relaxed ambiance with delightful drinks. Alternatively, go to Bitter Bar, the perfect place for those looking to experience the best of the nightlife. Similarly, Archea Brewery provides excellent drinks and a great atmosphere, ensuring a memorable night out.

Raise your glass and celebrate another amazing day of your road trip in Italy!

On day 14 of your exciting self-drive vacation in Italy, you’ll soak in the magnificence of 2 destinations, including Florence and Siena. When you’re not sightseeing, take time to relax at your chosen hotel in Pisa, where you’ll be staying for 1 night.

Visiting Cathedral Of Santa Maria Del Fiore is always a good idea. This spectacular church is a place that is appreciated by travelers and locals alike. Next, immerse yourself in the detailed wonders of Galleria Dell'accademia, a must-see art gallery in the city.

Consider stopping for a small bite to eat or a drink at a local eatery to keep your energy going. When you’re ready, continue your discovery with a visit to Central Market. This captivating food market offers an enriching experience.

Siena’s wonders await as you prepare for another journey on the road, leaving the breathtaking surroundings of Florence behind. This drive usually takes around 1 hour 19 min. Siena welcomes you with a multitude of unique vacation experiences.

Piazza Del Campo is a spectacular public square we recommend visiting today. Discover its UNESCO world heritage-designated features before continuing your self-guided tour.

After soaking up all the sights on today's itinerary, you'll be ready to head to your accommodation in Pisa. Pisa offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

Indulge in a memorable dining experience at one of Pisa's most popular restaurants, and connect with friendly locals for a true cultural experience.

Enjoy a delicious meal at Ristorante Capodimonte Pisa, a highly-rated dining destination in Pisa. If you're eager to try something different, consider La Locanda Dei Pisani Doc Pisa, another top spot with a tantalizing menu. You might also want to secure a reservation at Baribaldi Pisa. With a reputation for consistently satisfying customers, it’s an excellent choice to enhance your stay in Pisa this evening.

Let the evening flow smoothly from dinner to drinks at Bar Mocambo, a top-rated bar in the area. For other recommendations, Tree provides a perfect setting for rounding out your night with style and great drinks. Likewise, Chupiteria offers a memorable night with diverse drink options and excellent service.

Raise your glass to another unforgettable day in Italy!