Two-Week Italy Self-Drive Road Trip With Itinerary from Venice to Verona, Milan, Florence, and Rome

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Experience the freedom of the open road on an unforgettable 15-day road trip in Italy! Embark on a self-drive tour that caters to every traveler, featuring destinations like Venice, Murano, Burano, Verona, Sirmione, Sant'Alessandro, Malcesine, Peschiera del Garda, Milan, Lenno, Genoa, Riomaggiore, Manarola, Florence, Siena, Rome, and Santa Maria degli Angeli.

This perfectly planned road trip itinerary takes you through some of the best places to see in Italy. You will spend 3 nights in Venice, 2 nights in Verona, 3 nights in Milan, 4 nights in Florence, and 2 nights in Rome. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Italy. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have you covered.

Upon arriving in Venice, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Italy on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Italy. Trevi Fountain and Colosseum are just a couple of the bucket-list attractions that await your discovery.

As you hit the open road and drive through Venice, Murano, Burano, Verona, Sirmione, Sant'Alessandro, Malcesine, Peschiera del Garda, Milan, Lenno, Genoa, Riomaggiore, Manarola, Florence, Siena, Rome, and Santa Maria degli Angeli, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Italy. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Italy.

Throughout your road trip in Italy, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Italy.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodations, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in Italy fill up quickly, so book your spot early. Select a date and start planning your road trip in Italy today!

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Driver’s age is 30 - 65
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Pick-up: 10:00
Drop-off: 10:00

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Customize tours under each day and destination

Day 1

Day 1

  • Venice - Arrival day
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  • Rialto Bridge
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Welcome to Venice, the perfect starting point for your road trip in Italy! Pick up your rental car and let the adventure begin. You will spend 2 nights discovering what to see in Venice before embarking on the next leg of your journey.

Venice is a beautiful city with plenty to discover. Taking a stroll in the city center is a great alternative. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

When you're ready for some downtime, make your way to your chosen hotel. Check-in typically starts between 2 and 4 PM in Venice. Make yourself at home and unwind before heading out again.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Venice, it's often a good idea to reserve a table in advance.

Raise a toast to the start of your 15-day road trip in Italy!

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Day 2

Day 2

  • Venice
  • More

Drive 127 km, 2 hours 36 min

  • Doge's Palace
  • St Mark's Basilica
  • Murano
  • Burano
  • More

Wake up to day 2 of your road trip in Italy. On this day, you’ll embark on an exciting expedition discovering the enchanting sights and activities of Venice, Murano, and Burano. With 1 night to stay in Venice, we encourage you to seize the day and discover the unexplored beauty of the city’s surroundings!

When you’re done exploring the area’s best attractions, you’ll drive back to your accommodation in Venice.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Venice. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Get a good night's sleep and look forward to another great day on the road in Italy!

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Day 3

Day 3

  • Venice
  • Verona
  • More

Drive 119 km, 2 hours 4 min

  • Giusti Garden
  • Ponte Pietra
  • piazza delle Erbe
  • Verona Arena
  • Fontana di Piazza Bra
  • Castelvecchio Museum
  • More

On day 3 of your exciting self-drive vacation in Italy, you’ll soak in the magnificence of 1 destination, including Verona. When you’re not sightseeing, take time to relax at your chosen hotel in Verona, where you’ll be staying for 2 nights.

After soaking up all the sights on today's itinerary, you'll be ready to head to your accommodation in Verona. Verona offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Verona. Enjoy a relaxing evening as you savor delicious local cuisine.

Raise your glass and celebrate another amazing day of your road trip in Italy!

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Day 4

Day 4

  • Verona
  • More

Drive 254 km, 4 hours 32 min

  • Archaeological site of Grotte di Catullo
  • Castello di Sirmione
  • Forte Garda
  • Oriental Gardesana Integral Nature Reserve
  • Fortifications
  • More

On day 4 of your road trip, you’ll start and end your day in Verona, where you have 1 night left to stay.

When you’re done exploring for the day, you’ll return to Verona and your accommodation.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Verona. Enjoy a relaxing evening as you savor delicious local cuisine.

Celebrate another amazing day of your road trip adventure in Italy!

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Day 5

Day 5

  • Verona
  • Milan
  • More

Drive 170 km, 2 hours 34 min

  • Castello Sforzesco
  • Pinacoteca di Brera
  • Duomo di Milano
  • Galleria Vittorio Emanuele II
  • More

Dive into day 5 of your remarkable road trip in Italy. Today you'll explore 1 destination, including Milan. At the end of the day, you’ll unwind at one of the finest accommodations in Milan, where you'll spend 3 nights.

At the end of the day, you will drive to Milan, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

Milan is a place where the culinary landscape is as diverse as its attractions. So before the day ends, treat your palate to a taste of local cuisine at one of the best restaurants in Milan.

Get a good night's sleep and look forward to another great day on the road in Italy!

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Day 6

Day 6

  • Milan
  • More

Drive 217 km, 4 hours 2 min

  • Orrido di Bellano
  • Villa Carlotta
  • Villa del Balbianello
  • More

On day 6 of your road trip, you’ll start and end your day in Milan, where you still have 2 nights left. You'll spend part of the day exploring places of interest outside the immediate city, including Rogaro and Lenno.

When you’re done exploring the area’s best attractions, you’ll drive back to your accommodation in Milan.

Indulge in a memorable dining experience at one of Milan's most popular restaurants, and connect with friendly locals for a true cultural experience.

Head back to your accommodation in Milan and get some rest to prepare for another magical day of your road trip in Italy.

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Day 7

Day 7

  • Milan
  • More

Drive 312 km, 4 hours 38 min

  • Lighthouse of Genoa
  • Aquarium of Genoa
  • Via Garibaldi
  • Palazzo Podestà
  • Piazza Fontane Marose
  • piazza De Ferrari
  • More

Greet day 7 of your road trip in Italy with a smile and start your day with a hearty breakfast. You have 1 night to stay in Milan, so get ready to make the most of your time in the region. On the agenda for this day, you’ll find only the best things to see and do in Genoa.

When you’re done exploring for the day, you’ll return to Milan and your accommodation.

After a day of adventure, treat yourself to an exquisite dinner at one of Milan's best restaurants.

Say good night to Milan and look forward to another great day of your road trip in Italy!

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Day 8

Day 8

  • Milan
  • Florence
  • More

Drive 421 km, 6 hours 19 min

  • Church of San Giovanni Battista of Riomaggiore
  • Castle of Riomaggiore
  • Riomaggiore
  • Presepe di Manarola
  • Manarola Overlook Viewpoint
  • More

Experience an unparalleled adventure on day 8 of your road trip in Italy. This exciting part of your journey invites you to discover the renowned landmarks in 2 places, which are Riomaggiore and Manarola. At the end of the day, you will retreat to the hotel of your choice in Florence, where will spend 4 nights.

When you’re done exploring for the day, you’ll drive to your hotel in Florence. Check in and relax before you head out to tour the city.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Florence. Enjoy a satisfying meal that will recharge you for tonight's adventures.

As the sun sets, rest up and recharge for the next leg of your road trip in Italy.

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Day 9

Day 9

  • Florence
  • More

Drive 1 km, 17 min

  • Bargello National Museum
  • piazza della Signoria
  • Palazzo Vecchio
  • Uffizi Gallery
  • Ponte Vecchio
  • Oltrarno
  • More

Day 9 offers an itinerary packed with the best things to see in Venice. You’ll stay in Florence for 3 nights more, offering you enough time to explore at a relaxed pace.

Don’t forget to check out all the popular tours and experiences you can add to your travel plans in Italy. You can explore and select activities under each day of your itinerary.

After a day of adventure, treat yourself to an exquisite dinner at one of Florence's best restaurants.

Relax and recharge in preparation for another adventurous day in Italy!

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Day 10

Day 10

  • Florence
  • More

Drive 8 km, 1 hour 12 min

  • David
  • Galleria dell'Accademia
  • Cathedral of Santa Maria del Fiore
  • Giotto's Bell Tower
  • Basilica of Santa Croce in Florence
  • piazzale Michelangelo
  • More

You have 2 nights left in Florence. Take the opportunity to experience more of the best attractions and activities in the city.

Don’t forget to check out all the popular tours and experiences you can add to your travel plans in Italy. You can explore and select activities under each day of your itinerary.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Florence. Enjoy a satisfying meal that will recharge you for tonight's adventures.

As the sun sets, rest up and recharge for the next leg of your road trip in Italy.

Read more
Day 11

Day 11

  • Florence
  • More

Drive 158 km, 2 hours 50 min

  • Basilica of San Domenico
  • Palazzo Salimbeni
  • piazza del Campo
  • Pubblico Palace
  • Siena Cathedral
  • Porta Tufi
  • More

On day 11 of your road trip, you'll get the chance to experience Siena. At the end of the day, you'll drive back to Florence, where you still have 1 night left to stay.

When you’re done exploring the area’s best attractions, you’ll drive back to your accommodation in Florence.

Florence is a place where the culinary landscape is as diverse as its attractions. So before the day ends, treat your palate to a taste of local cuisine at one of the best restaurants in Florence.

Raise your glass to another unforgettable day in Italy!

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Day 12

Day 12

  • Florence
  • Rome
  • More

Drive 279 km, 4 hours 3 min

  • Colosseum
  • Roman Forum
  • Trevi Fountain
  • Pantheon
  • Piazza Navona
  • More

On day 12 of your road trip in Italy, your travel plans include 1 stop at the most scenic, wondrous, and interesting places in the region. Rome are on today's agenda. In the evening, you’ll end up in Rome, where you will stay for 2 nights.

After soaking up all the sights on today's itinerary, you'll be ready to head to your accommodation in Rome. Rome offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

Indulge in a memorable dining experience at one of Rome's most popular restaurants, and connect with friendly locals for a true cultural experience.

Say good night to Rome and look forward to another great day of your road trip in Italy!

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Day 13

Day 13

  • Rome
  • More

Drive 10 km, 1 hour 1 min

  • Vatican Museums
  • Sistine Chapel
  • St Peter's Basilica
  • Obelisk of St Peter's Square
  • Castel Sant'Angelo
  • Via del Corso
  • More

On day 13 of your road trip in Italy, you’ll start and end your day in Rome, but spend the day exploring what’s beyond the city. Since you still have 1 night to spend in Rome, there’s no need to rush. Experience Vatican City and Rome to the fullest today with this curated day itinerary.

When you’re done exploring for the day, you’ll return to Rome and your accommodation.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Rome, it's often a good idea to reserve a table in advance.

Savor another day of unforgettable experiences in Italy!

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Day 14

Day 14

  • Rome
  • Venice
  • More

Drive 608 km, 7 hours 17 min

  • Portico of Monte Frumentario
  • Pinacoteca Comunale Palazzo Vallemani
  • Basilica of San Francesco d'Assisi
  • More

Your itinerary for day 14 of your road trip in Italy includes 1 stop and features some of the highlights of Santa Maria degli Angeli. At the end of the day, enjoy the comforts of a top-rated hotel in Venice, where you'll spend 1 night.

At the end of the day, you will drive to Venice, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

After a day of adventure, treat yourself to an exquisite dinner at one of Venice's best restaurants.

Head back to your accommodation in Venice and get some rest to prepare for another magical day of your road trip in Italy.

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Day 15

Day 15

  • Venice - Departure day
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  • Grand Canal
  • More

Day 15 of your road trip in Italy is your departure day. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

Discover boutiques offering an array of stylish fashion choices. For those seeking luxury items, check out the area’s high-end stores.

Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Italy!

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How it works

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Shortly after booking, you’ll receive your full itinerary, including schedules, locations, and everything you need for a stress-free trip.
Personalize your itinerary
Each package includes a professionally crafted itinerary you can tailor to your travel style. A dedicated travel expert will make sure every detail fits your needs perfectly.
Easily make changes
Need to update plans? No problem. Whether before your trip or mid-journey, we’re just seconds away to help with quick adjustments.
Enjoy seamless planning
With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.
Explore with confidence
From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.
Secure your spot
Confirm your package instantly and lock in the best rate with secure payment and guaranteed availability.
Get instant confirmation
Shortly after booking, you’ll receive your full itinerary, including schedules, locations, and everything you need for a stress-free trip.
Personalize your itinerary
Each package includes a professionally crafted itinerary you can tailor to your travel style. A dedicated travel expert will make sure every detail fits your needs perfectly.
Easily make changes
Need to update plans? No problem. Whether before your trip or mid-journey, we’re just seconds away to help with quick adjustments.
Enjoy seamless planning
With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.
Explore with confidence
From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.

We guarantee

Your trip is protected, personalized, and priced right. No surprises, no stress.

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