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4-Day Sicily Self-Drive Road Trip With Itinerary from Palermo to Cefalù

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Photo of Palermo, Sicily, Italy. Seafront view.

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Experience the freedom of the open road in Sicily as you embark on an unforgettable 4-day road trip! This experience caters to every traveler, featuring destinations like Palermo, Cefalù, Agrigento, and Isabella.

This perfectly planned road trip itinerary in Sicily takes you through some of the best places to see in the country. You will spend 2 nights in Palermo and 1 night in Cefalù. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Sicily. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have got you covered.

Upon arriving in Palermo, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Sicily on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Sicily. Valle Dei Templi and Palermo Cathedral are just a couple of the bucket-list attractions that await your discovery. Marvel at the remarkable Quattro Canti, learn more about the unique Norman Palace, and immerse yourself in the vibrant atmosphere of Catacombe Dei Cappuccini.

As you hit the open road and drive through Palermo, Cefalù, Agrigento, and Isabella, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Sicily. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Sicily.

Throughout your road trip in Sicily, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Sicily.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodation, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in Sicily fill up quickly, so book your spot early. Select a date and start planning your road trip in Sicily today!

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Day 1

Palermo - Arrival day
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Foro Italico
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Your road trip adventure in Sicily begins as soon as you reach Palermo and pick up your car. You’ll stay in Palermo for 1 night and explore the best things to see and do, sample the local cuisine, and choose from a curated selection of the best hotels and places to stay in the city.

Palermo is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out Foro Italico, or just taking a stroll in the city center. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

As afternoon approaches, head to your chosen hotel in Palermo. Check-in typically starts around 2 to 4 PM at hotels in Italy. We recommend staying at a hotel in a central location for easy access to the best attractions, restaurants, and bars in the city.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Palermo, it's often a good idea to reserve a table in advance.

Enjoy a lovely meal at Cotto e Bollito, a top-rated place to have dinner tonight. Alternatively, if your taste buds call for something different, Bebop is another top choice with a popular menu. You could also check for a table at Eremiti Restaurant. As an establishment that gains consistently high praises from customers, it’s an ideal choice in Palermo tonight.

Continue the enjoyment post-dinner at Malox Cult, a cherished local gathering spot renowned for its welcoming atmosphere. Similarly, Ai Giudici offers a vibrant space for indulging in well-crafted drinks and engaging conversation. You may also want to check out Bar Italico. This bar is a favorite among both locals and visitors looking for a delightful evening out filled with laughter and fun.

Raise a toast to the start of your 4-day road trip in Sicily!

Day 2

Palermo
Cefalù
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Drive 72 km, 1 hour 45 min

Norman Palace
Palermo Cathedral
Quattro Canti
Fontana Pretoria
Cefalù Beach
Cathedral of Cefalù
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On day 2 of your road trip in Sicily, you will get a true taste of the freedom a self-drive vacation in Europe entails. Today’s travel plans include stops at the most scenic, wondrous, and interesting places in Palermo and Cefalù. In the evening, you’ll end up in Cefalù, where you will stay for 1 night.

Get ready for a day filled with fun adventures, scenic views, and photo-friendly spots in the charming city of Palermo. Your adventure starts at Norman Palace, a locally renowned local hot spot. Another notable attraction to explore is Palermo Cathedral. This well-known church is known for its historic appeal.

After soaking in the highlights of these sights, take some time to wander Palermo's streets and immerse yourself in the local atmosphere. When you're ready to continue your sightseeing adventure, head to Quattro Canti. This enchanting public square offers a fascinating experience that many visitors find memorable. Fontana Pretoria is also worth visiting, along with Spiaggia Di Cefalù. These standout landmarks offer unique experiences that add to the day’s enjoyment. End your day at Cefalù Cathedral. This locally renowned church provides a fitting finale to your sightseeing.

After soaking up all the sights of today's itinerary, you'll be ready to head in the direction of your accommodation in Cefalù. Cefalù offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

Indulge in a memorable dining experience at one of Cefalù's most popular restaurants, and connect with friendly locals for an authentic adventure.

Dine in style at Hotel Le Calette, a top recommendation for dinner tonight. Or, for a change of pace, Ristorante La Brace Cefalù boasts a menu that's sure to impress. Also, be sure to check out Sicilian Food & Drink. Known as a local hotspot, it’s a great choice for tonight in Cefalù.

After your meal, keep the night alive at a bar like Emme Café, known for its lively atmosphere.

Get a good night's sleep and look forward to another great day on the road in Sicily!

Day 3

Cefalù
Palermo
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Drive 307 km, 5 hours 11 min

Valle dei Templi
Temple of Heracles
Scala dei Turchi
Basilica San Calogero
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Experience an unparalleled adventure on day 3 of your road trip in Sicily. This exciting part of your journey invites you to discover the renowned landmarks in 3 vibrant destinations - Agrigento, Scavuzzo, and Isabella. After a day filled with exploration and new experiences, you will retreat to the hotel of your choice in Palermo. You will spend 1 night here for some well-deserved relaxation.

Today’s agenda in Cefalù includes an archeological site, a rock formation, and a church. Valle Dei Templi is must-visit archeological site and a great starting point for the day. Next, continue your journey to Temple Of Heracles, an up-and-coming archeological site, located just a leisurely stroll away. Next, head to Scala Dei Turchi, an eye-catching rock formation, also available for your discovery today.

At the end of the day, you will drive to Palermo, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

After a day of adventure, treat yourself to an exquisite dinner at one of Palermo's best restaurants.

Make sure to reserve a table at Osteria Mercede, an iconic dining spot in Palermo. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Trattoria Del Massimo, a popular restaurant in Palermo. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of Grand Hotel Piazza Borsa, a hidden gem nestled in Palermo. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

After enjoying a fulfilling meal, continue your evening at Spina Bar Palermo, ideal for those looking to unwind with a drink in a comfortable setting. Alternatively, Torrefazione Castagnetta Massimiliano (gelateria) offers a welcoming atmosphere for easing into the nightlife. Similarly, Monkey Pub provides an excellent environment for a relaxed and enjoyable evening.

As the day draws to a close, take a moment to unwind and prepare for the next exciting chapter of your road trip in in Sicily.

Day 4

Palermo - Departure day
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Catacombe dei Cappuccini
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Day 4 of your road trip in Sicily is your departure day. This is your chance to catch a last glimpse of Palermo before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

If you're up for some more sightseeing, begin at Catacombe Dei Cappuccini. This notable cemetery is a popular place to see in the city.

As your final day in Sicily unfolds, enjoy a last-minute shopping spree in Palermo's best shopping area. Enjoy finding the perfect gift or keepsake to remind you of your wonderful trip to Sicily.

Before you conclude your road trip in Sicily, drop by another restaurant for a last chance at a memorable dining experience in Palermo.

Treat yourself to a delightful dinner at Splendid Hotel la Torre, highly recommended for tonight's dining. Or, if you're feeling adventurous, why not try Ristorantino Sobremesa? It's another excellent option with a diverse menu.

You’ll then say farewell to Palermo. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Sicily!

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Shortly after booking, you’ll receive your full itinerary, including schedules, locations, and everything you need for a stress-free trip.

Personalize your itinerary

Each package includes a professionally crafted itinerary you can tailor to your travel style. A dedicated travel expert will make sure every detail fits your needs perfectly.

Easily make changes

Need to update plans? No problem. Whether before your trip or mid-journey, we’re just seconds away to help with quick adjustments.

Enjoy seamless planning

With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.

Explore with confidence

From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.

Secure your spot

Confirm your package instantly and lock in the best rate with secure payment and guaranteed availability.

Get instant confirmation

Shortly after booking, you’ll receive your full itinerary, including schedules, locations, and everything you need for a stress-free trip.

Personalize your itinerary

Each package includes a professionally crafted itinerary you can tailor to your travel style. A dedicated travel expert will make sure every detail fits your needs perfectly.

Easily make changes

Need to update plans? No problem. Whether before your trip or mid-journey, we’re just seconds away to help with quick adjustments.

Enjoy seamless planning

With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.

Explore with confidence

From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.

We guarantee

Your trip is protected, personalized, and priced right. No surprises, no stress.

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