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Road trips in Italy

4-Day Sicily Self-Drive Road Trip With Itinerary from Palermo to Agrigento and surrounding area

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Photo of Palermo, Sicily, Italy. Seafront view.

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Explore the best of Sicily on a remarkable 4-day road trip! Combine exploration with relaxation on a self-drive tour featuring Palermo, Agrigento, Monreale, and Isola delle Femmine.

This perfectly planned road trip itinerary takes you through some of the best places to see in Sicily. You will spend 2 nights in Palermo and 1 night in Agrigento. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Sicily. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have you covered.

Upon arriving in Palermo, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Sicily on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Sicily. Valle Dei Templi and Palermo Cathedral are just a couple of the bucket-list attractions that await your discovery. Marvel at the remarkable Cattedrale Di Monreale, learn more about the unique Quattro Canti, and immerse yourself in the vibrant atmosphere of Norman Palace.

As you hit the open road and drive through Palermo, Agrigento, Monreale, and Isola delle Femmine, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Sicily. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Sicily.

Throughout your road trip in Sicily, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Sicily.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodations, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in Sicily fill up quickly, so book your spot early. Select a date and start planning your road trip in Sicily today!

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Day 1

Palermo - Arrival day
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Quattro Canti
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Welcome to Palermo, the perfect starting point for your road trip in Italy! Pick up your rental car and let the adventure begin. You will spend 1 night discovering what to see in Palermo before embarking on the next leg of your journey.

Palermo is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out Quattro Canti, or just taking a stroll in the city center. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

Find your way to your hotel in Palermo. We recommend choosing a hotel in a central location for easy exploring. Check-in typically starts between 2 and 4 PM at hotels in Italy. Settle in and make plans for the evening.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Palermo, it's often a good idea to reserve a table in advance.

Make sure to reserve a table at Cotto e Bollito, an iconic dining spot in Palermo. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Bebop, a popular restaurant in Palermo. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of Eremiti Restaurant, a hidden gem nestled in Palermo. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

Cap off your dinner by heading to Malox Cult, ideal for a leisurely evening with a drink in hand. Ai Giudici is another bar that offers an enjoyable setting. Similarly, Bar Italico is also a popular place to go on a night out, perfect for relaxing and socializing.

Raise a toast to the start of your 4-day road trip in Sicily!

Day 2

Palermo
Agrigento
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Drive 137 km, 2 hours 31 min

Norman Palace
Palermo Cathedral
Orto botanico di Palermo
Catacombe dei Cappuccini
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Your itinerary for day 2 of your road trip in Sicily includes 1 stop and features some of the highlights of Palermo. At the end of the day, enjoy the comforts of a top-rated hotel in Agrigento, where you'll spend 1 night.

Start your day at Norman Palace. This culturally significant palace is an interesting place to see in Palermo. Then, wander over to Palermo Cathedral. If symbolic sites excite you, this church will be right up your alley. Nearby, you’ll also find Orto Botanico Di Palermo. This romantic botanical garden is a favorite among visitors.

Palermo offers plenty to explore, ensuring every moment of your visit is filled with excitement and discovery. If you're up for more, Catacombe Dei Cappuccini is an interesting spot in the city that will captivate you with its unique charm.

When you’re done exploring for the day, you’ll drive to your hotel in Agrigento. Check in and relax before you head out to tour the city.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Agrigento. Enjoy a relaxing evening as you savor delicious local cuisine.

Dine in style at Ambasciata di Sicilia, a top recommendation for dinner tonight. Or, for a change of pace, Le Cuspidi boasts a menu that's sure to impress. Also, be sure to check out Yellove RistoVintage. Known as a local hotspot, it’s a great choice for tonight in Agrigento.

Relax and recharge in preparation for another adventurous day in Sicily!

Day 3

Agrigento
Palermo
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Drive 212 km, 3 hours 37 min

Scala dei Turchi
Valle dei Templi
Cattedrale di Monreale
Monumento alla Strage di Capaci
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Dive into day 3 of your remarkable road trip in Sicily. Today you'll explore 4 destinations, including Scavuzzo, Agrigento, Monreale, and Isola delle Femmine. At the end of the day, you’ll unwind at one of the finest accommodations in Palermo, where you'll spend 1 night.

Your adventure in Agrigento is only getting started when you visit Scala Dei Turchi, an often recommended local hot spot. Another notable attraction to explore is Valle Dei Templi. This notable archeological site is known for its mesmerizing appeal.

After soaking in the highlights of these sights, take some time to wander Agrigento's streets and immerse yourself in the local atmosphere. When you're ready to continue your sightseeing adventure, head to Cattedrale Di Monreale. This historic church offers a fascinating experience that many visitors find memorable. Monumento Alla Strage Di Capaci is also worth visiting.

After soaking up all the sights on today's itinerary, you'll be ready to head to your accommodation in Palermo. Palermo offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Palermo. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Prepare for an extraordinary culinary adventure in Palermo by booking a table at Buatta Cucina Popolana, a Bib Gourmand restaurant that boasts an exceptional sicilian menu. For a different flavor experience, head to Mec Restaurant, renowned for its delectable sicilian and contemporary dishes. This 1-star Michelin restaurant consistently wows guests, making it a memorable stop during your holiday. Looking for another option? Visit Gagini Restaurant, a local gem known for its delightful creative and contemporary cuisine in Palermo. Nestled in the city's heart, this 1-star Michelin restaurant is a perfect choice for discerning restaurant-goers seeking a new experience.

Keep the evening going at Spina Bar Palermo, a great choice for enjoying the after-dinner hours with a drink. You could also go to Torrefazione Castagnetta Massimiliano (gelateria), which offers a similarly pleasant setting and great drinks. Another option is Monkey Pub, which provides an inviting environment for unwinding after a busy day out.

Raise your glass and celebrate another amazing day of your road trip in Sicily!

Day 4

Palermo - Departure day
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Foro Italico
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Day 4 of your road trip in Sicily is your departure day. This is your chance to catch a last glimpse of Palermo before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

If you're up for some more sightseeing, begin at Foro Italico. This often recommended park is a hotspot among locals.

Before you conclude your road trip in Sicily, drop by another restaurant for a last chance at a memorable dining experience in Palermo.

Savor the flavors at Splendid Hotel la Torre, a top pick for dinner tonight. Alternatively, Ristorantino Sobremesa beckons with its unique menu offerings.

You’ll then say farewell to Palermo. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Sicily!

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Shortly after booking, you’ll receive your full itinerary, including schedules, locations, and everything you need for a stress-free trip.

Personalize your itinerary

Each package includes a professionally crafted itinerary you can tailor to your travel style. A dedicated travel expert will make sure every detail fits your needs perfectly.

Easily make changes

Need to update plans? No problem. Whether before your trip or mid-journey, we’re just seconds away to help with quick adjustments.

Enjoy seamless planning

With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.

Explore with confidence

From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.

Secure your spot

Confirm your package instantly and lock in the best rate with secure payment and guaranteed availability.

Get instant confirmation

Shortly after booking, you’ll receive your full itinerary, including schedules, locations, and everything you need for a stress-free trip.

Personalize your itinerary

Each package includes a professionally crafted itinerary you can tailor to your travel style. A dedicated travel expert will make sure every detail fits your needs perfectly.

Easily make changes

Need to update plans? No problem. Whether before your trip or mid-journey, we’re just seconds away to help with quick adjustments.

Enjoy seamless planning

With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.

Explore with confidence

From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.

We guarantee

Your trip is protected, personalized, and priced right. No surprises, no stress.

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