5-Day Sicily Self-Drive Road Trip With Itinerary from Catania traveling south to Syracuse

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Piazza del Duomo in Catania on a summer day, with Duomo of Saint Agatha and the Elephant Fountain. Sicily, southern Italy. View of Cathedral Sant Agata on Piazza del Duomo in Catania, Sicily, Italy.
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Escape the ordinary with this exciting 5-day road trip through Sicily. Explore diverse landscapes, discover lively cities, and prepare for an unforgettable journey!

This perfectly planned road trip itinerary takes you through some of the best places to see in Sicily. You will spend 2 nights in Catania and 2 nights in Syracuse. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Sicily. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have you covered.

Upon arriving in Catania, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Sicily on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Sicily. Neapolis Archaeological Park and Giardino Bellini are just a couple of the bucket-list attractions that await your discovery. Marvel at the remarkable Temple Of Apollo, learn more about the unique Nature Reserve Of Vendicari, and immerse yourself in the vibrant atmosphere of Castello Ursino.

As you hit the open road and drive through Catania, Syracuse, Noto, and Ragusa, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Sicily. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Sicily.

Throughout your road trip in Sicily, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Sicily.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodations, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in Sicily fill up quickly, so book your spot early. Select a date and start planning your road trip in Sicily today!

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Driver’s age is 30 - 65
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Pick-up: 10:00
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Day 1

Day 1

  • Catania - Arrival day
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Your road trip adventure in Sicily begins as soon as you reach Catania and pick up your car. You’ll stay here for 1 night and explore what to see in Catania, sample the local cuisine, and choose from a curated selection of the best hotels and places to stay in the city.

Catania is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out taking a stroll in the city center. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

As afternoon approaches, head to your chosen hotel in Catania. Check-in typically starts around 2 to 4 PM at hotels in Italy. We recommend staying at a central location for easy access to key areas in the city.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Catania, it's often a good idea to reserve a table in advance.

Make sure to reserve a table at Ristorante da Antonio, an iconic dining spot in Catania. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of Lido Arcobaleno, a popular restaurant in Catania. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of Lido Azzurro, a hidden gem nestled in Catania. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

Unwind after your meal by stepping into Caffè Europa. This venue is celebrated for its extensive drink selections and cozy vibes. Alternatively, Insigne Cafè offers a dynamic and energetic atmosphere for a glass or two. Don’t overlook Bohéme Mixology Bar, another top-rated bar in the area.

Raise a toast to the start of your 5-day road trip in Sicily!

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Day 2

Day 2

  • Catania
  • Syracuse
  • More

Drive 71 km, 1 hour 16 min

  • Fountain of the Elephant
  • Basilica Cattedrale di Sant'Agata
  • Villa Bellini/Chiosco Bellini
  • Piazza Università
  • Castello Ursino
  • More

Dive into day 2 of your remarkable road trip in Sicily. Today you'll explore 1 destination, including Catania. At the end of the day, you’ll unwind at one of the finest accommodations in Syracuse, where you'll spend 2 nights.

No visit to Catania is complete without Elephant Fountain. This locally appreciated monument is one of the top attractions in the city. Proceed to Catania Cathedral, another must-visit attraction.

As you wander through the inviting streets of Catania, soak in the lively ambiance and take the opportunity to snap some photos. Next, head to Giardino Bellini. This locally renowned park is a traveler-favorite. Not far away, you’ll find Piazza Università, another key site on your sightseeing itinerary. Castello Ursino is yet another highly recommended place to visit nearby, offering plenty to discover for curious travelers.

After soaking up all the sights on today's itinerary, you'll be ready to head to your accommodation in Syracuse. Syracuse offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Syracuse. Enjoy a relaxing evening as you savor delicious local cuisine.

Treat yourself to an extraordinary dining experience at Cortile Spirito Santo, a 1-star Michelin restaurant offering an incredible creative and modern menu. Alternatively, if your taste buds call for something different, Dock Café Restaurant is another top choice with a popular menu.

Extend your evening after a delightful meal by visiting Barcollo, which offers the perfect atmosphere for a night out. Moreover, Bar Pasticceria Midolo is another popular option for a drink or two. Likewise, Boats also provides a great ambiance for reminiscing about the day and raising a toast to your vacation.

Savor another day of unforgettable experiences in Sicily!

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Day 3

Day 3

  • Syracuse
  • More

Drive 11 km, 36 min

  • Ear of Dionysius
  • Neapolis Archaeological Park
  • Fountain of Diana
  • Island of Ortigia
  • Cathedral of Syracuse
  • More

Day 3 of your road trip will take you to the best attractions Syracuse has to offer. Cherish the 1 night you have left in the city and use the provided itinerary to discover what to see in Syracuse.

One of the most frequently visited attractions included on the itinerary is Ear Of Dionysius. This picture-perfect cave will help you start your sightseeing on top. Then, take a leisurely stroll to Neapolis Archaeological Park and learn what makes this UNESCO world heritage-designated archeological site unique.

Throughout the day, make sure to take breaks to appreciate the surroundings. Next up, visit the underrated Diana Fountain. After exploring the monument, head to Ortygia. This beloved historical landmark is a highlight in Syracuse. As your day continues, stop by Cathedral Of Syracuse, known for its romantic features.

Don’t forget to check out all the popular tours and experiences you can add to your travel plans in Sicily. You can explore and select activities under each day of your itinerary.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Syracuse. Enjoy a relaxing evening as you savor delicious local cuisine.

Treat yourself to a wonderful meal at La Lisca Cucina e Bottega, a top-rated dining spot in Syracuse. If you're in the mood for something new, try SICULISH HERE AND NOW, another premier location with a delectable menu. You might also want to book a table at Ammucca - Sicilian Quality Meat Food. Known for its consistently satisfied patrons, it’s a perfect choice to elevate your evening in Syracuse.

Keep the excitement of the evening going by visiting a bar or two. Bar Tunisi is an excellent place to start. You could also check out Verga Courtyard - Cafeteria, offering a different kind of charm. A last recommendation for the day is Glam Café. This bar promises an enjoyable experience with tasty drinks and a vibrant setting.

As the day draws to a close, take a moment to unwind and prepare for the next exciting chapter of your road trip in Sicily.

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Day 4

Day 4

  • Syracuse
  • Catania
  • More

Drive 214 km, 4 hours 44 min

  • Temple of Apollo
  • Riserva Naturale Cavagrande del Cassibile
  • Nature reserve of Vendicari
  • Giardino Ibleo
  • More

On day 4 of your exciting self-drive vacation in Sicily, you’ll soak in the magnificence of 3 destinations, including Syracuse, Noto, and Ragusa. When you’re not sightseeing, take time to relax at your chosen hotel in Catania, where you’ll be staying for 1 night.

Check out the captivating archeological site, Temple Of Apollo. Afterward, continue to Riserva Naturale Cavagrande Del Cassibile, a nature reserve every traveler should visit. As you explore Syracuse’s charming streets, take in the lively atmosphere and get to know the character of the city.

Next, make your way to Nature Reserve Of Vendicari. This popular nature reserve is an essential stop. Following that, head to Giardino Ibleo, another must-visit site that will enhance your experience.

At the end of the day, you will drive to Catania, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

After a day of adventure, treat yourself to an exquisite dinner at one of Catania's best restaurants.

Experience a symphony of flavors at Me Cumpari Turiddu in Catania by securing a reservation in advance. Renowned for its Bib Gourmand distinction, Me Cumpari Turiddu delights its guests with its exceptional variety of meals showcasing delicious sicilian cuisine. For a palate-pleasing alternative, make sure to dine at Sapio, acclaimed for its delectable sicilian and modern specialties. This local 1-star Michelin establishment consistently satisfies guests, ensuring an unforgettable holiday experience. Want to go on another culinary journey? Delight your senses at Osteria Acqualavica, a top-rated restaurant known for its outstanding menu. Known as a top-rated Bib Gourmand-establishment, it's a top choice for sicilian and seafood cuisine in the city.

Keep the evening going at Circus Cocktail Bar, a great choice for enjoying the after-dinner hours with a drink. You could also go to Caffè Opera, which offers a similarly pleasant setting and great drinks. Another option is Chiosco Sicilia Seltz, which provides an inviting environment for unwinding after a busy day out.

Raise your glass to another unforgettable day in Sicily!

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Day 5

Day 5

  • Catania - Departure day
  • More

Day 5 of your road trip in Sicily is your departure day. This is your chance to catch a last glimpse of Catania before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

For a shopping spree in Catania, we recommend the lively Via Etnea. Here, you'll find a range of shops you can browse for some souvenir shopping. Discover boutiques with stylish fashion choices to upgrade your wardrobe.

Before you conclude your road trip in Sicily, drop by another restaurant for a last chance at a memorable dining experience in Catania.

If you're in the mood to try something new, consider Carlito's, another top spot with a mouthwatering menu.

You’ll then say farewell to Catania. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Sicily!

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Easily make changes
Need to update plans? No problem. Whether before your trip or mid-journey, we’re just seconds away to help with quick adjustments.
Enjoy seamless planning
With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.
Explore with confidence
From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.
Secure your spot
Confirm your package instantly and lock in the best rate with secure payment and guaranteed availability.
Get instant confirmation
Shortly after booking, you’ll receive your full itinerary, including schedules, locations, and everything you need for a stress-free trip.
Personalize your itinerary
Each package includes a professionally crafted itinerary you can tailor to your travel style. A dedicated travel expert will make sure every detail fits your needs perfectly.
Easily make changes
Need to update plans? No problem. Whether before your trip or mid-journey, we’re just seconds away to help with quick adjustments.
Enjoy seamless planning
With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.
Explore with confidence
From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.

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