5-Day Italy Self-Drive Road Trip With Itinerary from Genoa to Portofino and Pisa

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Explore the best of Italy on a 5-day road trip! Uncover hidden gems and experience the rich culture firsthand as you journey through Genoa, Portofino, Corniglia, Pisa, Florence, and Lucca. This road trip itinerary in Italy seamlessly combines exploration with relaxation.

This perfectly planned road trip itinerary in Italy takes you through some of the best places to see in the country. You will spend 2 nights in Genoa, 1 night in Portofino, and 1 night in Pisa. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Italy. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have got you covered.

Upon arriving in Genoa, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Italy on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Italy. Ponte Vecchio and Leaning Tower Of Pisa are just a couple of the bucket-list attractions that await your discovery. Marvel at the remarkable Piazza Del Duomo, Pisa, learn more about the unique Uffizi Gallery, and immerse yourself in the vibrant atmosphere of Aquarium Of Genoa.

As you hit the open road and drive through Genoa, Portofino, Corniglia, Pisa, Florence, and Lucca, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Italy. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Italy.

Throughout your road trip in Italy, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Italy.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodation, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in Italy fill up quickly, so book your spot early. Select a date and start planning your road trip in Italy today!

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Itinerary summary

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Days
Destination
Attractions
Overnight
Day
City & Overnight
Attractions
Aquarium of Genoa
piazza De FerrariGenoa CathedralDoge's PalaceVia GaribaldiGalata - Museo del mareArea Marina Protetta di Portofino
Cinque Terre National ParkLeaning Tower of PisaPiazza del Duomo, Pisa
Basilica of Santa Croce in FlorenceUffizi GalleryPonte VecchioWalls of Lucca
porto antico

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Day 1

Day 1

  • Genoa - Arrival day
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  • Aquarium of Genoa
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Say hello to Genoa! Your exciting road trip through Italy is just about to start. Navigating the top places to see in the region is a breeze with a car. The rental vehicle of your choice will be ready for pickup upon your arrival in the city. You will stay in Genoa for 1 night before you continue your adventure!

Genoa is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out Aquarium Of Genoa, or just taking a stroll in the city center. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

As afternoon approaches, head to your chosen hotel in Genoa. Check-in typically starts around 2 to 4 PM at hotels in Italy. We recommend staying at a hotel in a central location for easy access to the best attractions, restaurants, and bars in the city.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Genoa, it's often a good idea to reserve a table in advance.

Savor the flavors at 7 Sensi cucina decontaminata, a top pick for dinner tonight. Alternatively, Alla Lunga Ristorante beckons with its unique menu offerings. Also, consider Grand Hotel Savoia. With its consistent customer satisfaction, it’s an excellent option for dining in Genoa tonight.

After enjoying a delightful dinner, why not delve into the vibrant local bar scene? You might want to spend the evening at Scurreria Beer & Bagel, a well-loved spot among locals and tourists. Or, head to La Lepre. This bar boasts a welcoming environment that is perfect for winding down. You could also continue your night at Bar Pisacane Iii, another top-rated place in the area.

Raise a toast to the start of your 5-day road trip in Italy!

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Day 2

Day 2

  • Genoa
  • Portofino
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Drive 58 km, 1 hour 51 min

  • piazza De Ferrari
  • Genoa Cathedral
  • Doge's Palace
  • Via Garibaldi
  • Galata - Museo del mare
  • Area Marina Protetta di Portofino
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On day 2 of your road trip in Italy, you will get a true taste of the freedom a self-drive vacation in Europe entails. Today’s travel plans include stops at the most scenic, wondrous, and interesting places in Genoa and San Fruttuoso di Camogli. In the evening, you’ll end up in Portofino, where you will stay for 1 night.

Bring your curiosity for today’s adventure around Genoa. Some of the city’s most loved attractions await! Piazza De Ferrari is the perfect place to start. This public square is one of the most locally renowned places to visit in Genoa. Next, head to Genoa Cathedral, an underrated church, known for its monumental features.

Nearby, you'll also find Via Garibaldi and Galata Museo Del Mare (complex). Visit these for an interesting touch to your journey. Finish the day with a visit to Area Marina Protetta Di Portofino, a mesmerizing nature reserve in Genoa.

After soaking up all the sights of today's itinerary, you'll be ready to head in the direction of your accommodation in Portofino. Portofino offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

After a day of adventure, treat yourself to an exquisite dinner at one of Portofino's best restaurants.

Enjoy a delicious meal at Trattoria Concordia, a highly-rated dining destination in Portofino. If you're eager to try something different, consider Ristorante Da Ö Batti Portofino - Ristorante Da Ö Batti, another top spot with a tantalizing menu. You might also want to secure a reservation at Ristorante Puny. With a reputation for consistently satisfying customers, it’s an excellent choice to enhance your stay in Portofino this evening.

Take some time to reflect on your day and savor another beautiful night in Italy.

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Day 3

Day 3

  • Portofino
  • Pisa
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Drive 185 km, 3 hours 33 min

  • Cinque Terre National Park
  • Leaning Tower of Pisa
  • Piazza del Duomo, Pisa
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On day 3 of your exciting self-drive vacation in Italy, you’ll soak in the magnificence of 2 destinations, Corniglia and Pisa. When you’re not sightseeing, take time to relax at your selected hotel in Pisa, where you’ll be staying for 1 night.

Get ready for a day filled with family-friendly attractions, romantic experiences, and natural wonders in the charming village of Portofino. Your adventure starts at Cinque Terre National Park, an interesting local hot spot. Another notable attraction to explore is Leaning Tower Of Pisa. This timeless monument is known for its awe-inspiring appeal.

After soaking in the highlights of these sights, take some time to wander Portofino's streets and immerse yourself in the local atmosphere. When you're ready to continue your sightseeing adventure, head to Piazza Del Duomo, Pisa. This historic public square offers a fascinating experience that many visitors find memorable.

When you’re done exploring for the day, you’ll drive to your hotel in Pisa. Check in and spend some time relaxing before you head out to tour the city.

Indulge in a memorable dining experience at one of Pisa's most popular restaurants, and connect with friendly locals for an authentic adventure.

Dine in style at Anima di Grano Pizzeria Napoletana Pisa Italy, a top recommendation for dinner tonight. Or, for a change of pace, il Mercante boasts a menu that's sure to impress. Also, be sure to check out La Ghiotteria. Known as a local hotspot, it’s a great choice for tonight in Pisa.

Cap off your dinner by heading to Jeffer Cocktails & Friends, ideal for a leisurely evening with a drink in hand. Le Parisien Wine Bar is another bar that offers an enjoyable setting. Similarly, Las Volta Cocktailbar is also a popular place to go on a night out, perfect for relaxing and socializing.

Get a good night's sleep and look forward to another great day on the road in Italy!

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Day 4

Day 4

  • Pisa
  • Genoa
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Drive 323 km, 4 hours 28 min

  • Basilica of Santa Croce in Florence
  • Uffizi Gallery
  • Ponte Vecchio
  • Walls of Lucca
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Dive into day 4 of your remarkable road trip in Italy. Today you will explore Florence and Lucca, where you will have the opportunity to experience all the top things to see and do. At the end of the day, you’ll unwind at one of the finest accommodations in Genoa. You’ll stay here for 1 night.

Savor the day by visiting some of the best places to see in Pisa, including a church, an art gallery, and a historical landmark. Start your adventure at Basilica Of Santa Croce In Florence. This notable church is a must-visit for travelers looking for a unique holiday experience. Make your way to Uffizi Gallery located in Pisa for another exciting encounter.

Next, immerse yourself in the setting of Ponte Vecchio. Its romantic features will captivate you. After the historical landmark, continue your tour of the city with a visit to Mura Di Lucca. Visitors usually appreciate the romantic features of this historical landmark.

At the end of the day, you will drive to Genoa, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

As you explore more of Genoa, you'll discover that its culinary landscape is as diverse as its attractions. Whether you're craving traditional dishes bursting with local flavors or innovative creations that push the boundaries of taste, you're sure to find a dining experience that satisfies your cravings.

Have a fantastic dining experience at Zeffirino, a highly recommended choice for tonight's dinner. If you're looking to mix things up, Trattoria Vegia Zena offers an enticing alternative with its varied menu. Additionally, Trattoria delle Grazie is worth considering. Renowned for satisfying diners, it’s an ideal option for tonight in Genoa.

Relax and recharge in preparation for another adventurous day in Italy!

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Day 5

Day 5

  • Genoa - Departure day
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  • porto antico
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Day 5 of your road trip in Italy is your departure day. This is your chance to catch a last glimpse of Genoa before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

If you're up for some more sightseeing, we recommend visiting Porto Antico, an enchanting public square before you head out.

Explore local shops for souvenirs to remember your trip or find unique gifts for loved ones.

Before you conclude your road trip in Italy, drop by another restaurant for a last chance at a memorable dining experience in Genoa.

If you're in the mood to try something new, consider La Cialtroneria, another top spot with a mouthwatering menu.

You’ll then say farewell to Genoa. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Italy!

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