5-Day Italy Self-Drive Road Trip With Itinerary from Genoa to Portofino and Pisa

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Photo of Sand beach in Camogli by Genoa, Italy.
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Explore the best of Italy on a remarkable 5-day road trip! Combine exploration with relaxation on a self-drive tour featuring Genoa, Portofino, Corniglia, Pisa, Florence, and Lucca.

This perfectly planned road trip itinerary takes you through some of the best places to see in Italy. You will spend 2 nights in Genoa, 1 night in Portofino, and 1 night in Pisa. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Italy. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have you covered.

Upon arriving in Genoa, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Italy on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Italy. Ponte Vecchio and Leaning Tower Of Pisa are just a couple of the bucket-list attractions that await your discovery. Marvel at the remarkable Piazza Del Duomo, Pisa, learn more about the unique Uffizi Gallery, and immerse yourself in the vibrant atmosphere of Aquarium Of Genoa.

As you hit the open road and drive through Genoa, Portofino, Corniglia, Pisa, Florence, and Lucca, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Italy. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Italy.

Throughout your road trip in Italy, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Italy.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodations, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in Italy fill up quickly, so book your spot early. Select a date and start planning your road trip in Italy today!

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Driver’s age is 30 - 65
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Pick-up: 10:00
Drop-off: 10:00

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Day 1

Day 1

  • Genoa - Arrival day
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  • Aquarium of Genoa
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Welcome to Genoa, the perfect starting point for your road trip in Italy! Pick up your rental car and let the adventure begin. You will spend 1 night discovering what to see in Genoa before embarking on the next leg of your journey.

Genoa is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out Aquarium Of Genoa, or just taking a stroll in the city center. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

Find your way to your hotel in Genoa. We recommend choosing a hotel in a central location for easy exploring. Check-in typically starts between 2 and 4 PM at hotels in Italy. Settle in and make plans for the evening.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Genoa, it's often a good idea to reserve a table in advance.

Have a fantastic dining experience at 7 Sensi cucina decontaminata, a highly recommended choice for tonight's dinner. If you're looking to mix things up, Alla Lunga Ristorante offers an enticing alternative with its varied menu. Additionally, Grand Hotel Savoia is worth considering. Renowned for satisfying diners, it’s an ideal option for tonight in Genoa.

After your meal, keep the night alive at a bar like Scurreria Beer & Bagel, known for its lively atmosphere. La Lepre is another top recommendation that provides the perfect setting with well-crafted drinks and a welcoming ambiance. Similarly, Bar Pisacane Iii offers an excellent atmosphere for those looking to amp up the evening.

Raise a toast to the start of your 5-day road trip in Italy!

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Day 2

Day 2

  • Genoa
  • Portofino
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Drive 58 km, 1 hour 51 min

  • piazza De Ferrari
  • Genoa Cathedral
  • Doge's Palace
  • Via Garibaldi
  • Galata - Museo del mare
  • Area Marina Protetta di Portofino
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Your itinerary for day 2 of your road trip in Italy includes 2 stops and features some of the highlights of Genoa and San Fruttuoso di Camogli. At the end of the day, enjoy the comforts of a top-rated hotel in Portofino, where you'll spend 1 night.

No visit to Genoa is complete without Piazza De Ferrari. This locally renowned public square is one of the top attractions in the city. Proceed to Genoa Cathedral, another must-visit attraction.

As you wander through the inviting streets of Genoa, soak in the lively ambiance and take the opportunity to snap some photos. Next, head to Doge's Palace. This frequently visited museum is a traveler-favorite. Not far away, you’ll find Via Garibaldi, another key site on your sightseeing itinerary. Galata Museo Del Mare (complex) is yet another highly recommended place to visit nearby, offering plenty to discover for curious travelers. Conclude your day at Area Marina Protetta Di Portofino and uncover why it's recognized as one of the city's most intriguing attractions.

At the end of the day, you will drive to Portofino, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Portofino. Enjoy a relaxing evening as you savor delicious local cuisine.

Treat yourself to a delightful dinner at Trattoria Concordia, highly recommended for tonight's dining. Or, if you're feeling adventurous, why not try Ristorante Da Ö Batti Portofino - Ristorante Da Ö Batti? It's another excellent option with a diverse menu. Consider reserving a table at Ristorante Puny as well. Known for its consistent customer satisfaction, it’s an ideal pick for tonight in Portofino.

Take some time to reflect on your day and savor another beautiful night in Italy.

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Day 3

Day 3

  • Portofino
  • Pisa
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Drive 185 km, 3 hours 33 min

  • Cinque Terre National Park
  • Leaning Tower of Pisa
  • Piazza del Duomo, Pisa
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Experience an unparalleled adventure on day 3 of your road trip in Italy. This exciting part of your journey invites you to discover the renowned landmarks in 2 places, which are Corniglia and Pisa. At the end of the day, you will retreat to the hotel of your choice in Pisa, where will spend 1 night.

Cinque Terre National Park brings Portofino's character to life. This eye-catching national park is a highlight of any visit in the village. Then, enjoy Leaning Tower Of Pisa, another historic attraction that never fails to captivate visitors. Next, head over to Piazza Del Duomo, Pisa, one of the village’s most world-famous attractions, known for its breathtaking features.

When you’re done exploring for the day, you’ll drive to your hotel in Pisa. Check in and relax before you head out to tour the city.

Indulge in a memorable dining experience at one of Pisa's most popular restaurants, and connect with friendly locals for a true cultural experience.

Make sure to reserve a table at Anima di Grano Pizzeria Napoletana Pisa Italy, an iconic dining spot in Pisa. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of il Mercante, a popular restaurant in Pisa. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of La Ghiotteria, a hidden gem nestled in Pisa. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

Keep the evening going at Jeffer Cocktails & Friends, a great choice for enjoying the after-dinner hours with a drink. You could also go to Le Parisien Wine Bar, which offers a similarly pleasant setting and great drinks. Another option is Las Volta Cocktailbar, which provides an inviting environment for unwinding after a busy day out.

Celebrate another amazing day of your road trip adventure in Italy!

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Day 4

Day 4

  • Pisa
  • Genoa
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Drive 323 km, 4 hours 28 min

  • Basilica of Santa Croce in Florence
  • Uffizi Gallery
  • Ponte Vecchio
  • Walls of Lucca
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On day 4 of your road trip in Italy, your travel plans include 2 stops at the most scenic, wondrous, and interesting places in the region. Florence and Lucca are on today's agenda. In the evening, you’ll end up in Genoa, where you will stay for 1 night.

Basilica Of Santa Croce In Florence is must-visit church and a great option for a daytime tour of the area. Continue your journey to Uffizi Gallery, an impressive art gallery, located just a leisurely stroll away. Next, head to Ponte Vecchio, a visually striking historical landmark, also available for your discovery today.

After soaking up all the sights on today's itinerary, you'll be ready to head to your accommodation in Genoa. Genoa offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

Genoa is a place where the culinary landscape is as diverse as its attractions. So before the day ends, treat your palate to a taste of local cuisine at one of the best restaurants in Genoa.

Enjoy a lovely meal at Zeffirino, a top-rated place to have dinner tonight. Alternatively, if your taste buds call for something different, Trattoria Vegia Zena is another top choice with a popular menu. You could also check for a table at Trattoria delle Grazie. As an establishment that consistently gains high praises from customers, it’s an ideal choice in Genoa tonight.

As the sun sets, rest up and recharge for the next leg of your road trip in Italy.

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Day 5

Day 5

  • Genoa - Departure day
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  • porto antico
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Day 5 of your road trip in Italy is your departure day. This is your chance to catch a last glimpse of Genoa before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

If you're up for some more sightseeing, begin at Porto Antico. This interesting public square is a hotspot among locals.

For a shopping spree in Genoa, we recommend the lively Via XX Settembre. Here, you'll find a range of shops you can browse for some souvenir shopping.

Before you conclude your road trip in Italy, drop by another restaurant for a last chance at a memorable dining experience in Genoa.

Savor the flavors at Osteria Sant'Ilario, a top pick for dinner tonight. Alternatively, La Cialtroneria beckons with its unique menu offerings.

You’ll then say farewell to Genoa. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Italy!

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Shortly after booking, you’ll receive your full itinerary, including schedules, locations, and everything you need for a stress-free trip.
Personalize your itinerary
Each package includes a professionally crafted itinerary you can tailor to your travel style. A dedicated travel expert will make sure every detail fits your needs perfectly.
Easily make changes
Need to update plans? No problem. Whether before your trip or mid-journey, we’re just seconds away to help with quick adjustments.
Enjoy seamless planning
With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.
Explore with confidence
From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.
Secure your spot
Confirm your package instantly and lock in the best rate with secure payment and guaranteed availability.
Get instant confirmation
Shortly after booking, you’ll receive your full itinerary, including schedules, locations, and everything you need for a stress-free trip.
Personalize your itinerary
Each package includes a professionally crafted itinerary you can tailor to your travel style. A dedicated travel expert will make sure every detail fits your needs perfectly.
Easily make changes
Need to update plans? No problem. Whether before your trip or mid-journey, we’re just seconds away to help with quick adjustments.
Enjoy seamless planning
With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.
Explore with confidence
From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.

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Your trip is protected, personalized, and priced right. No surprises, no stress.

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