5-Day Italy Self-Drive Road Trip With Itinerary from Genoa to Portofino and Pisa

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Photo of Sand beach in Camogli by Genoa, Italy.
Photo of Piazza De Ferrari main square in Genoa Italy.
Photo of Courtyard of Palazzo Reale in Genoa, Italy.
Photo of View of Genoa at sunset from "Spianata Castelletto", Italy.
Photo of Sestri Levante - Paradise Bay of Silence with its boats and its lovely beach. Beautiful coast at Province of Genoa in Liguria, Italy - Europe.
Photo of Genoa, Liguria, Italy downtown city skyline from above at dusk.
Photo of The Aquarium of Genoa is the largest aquarium in Italy. Located in the old harbor area of Genova.
Photo of Genoa port from above at night.
Photo of Palace of St George (Palazzo San Giorgio), Genoa, Italy.
Photo of Genova Brignole Railway Station in the evening.
Photo of View of Bogliasco. Bogliasco is a ancient fishing village in Italy, Genoa, Liguria. Mediterranean Sea, sandy beach and architecture of Bogliasco town.
Photo of Beach with tourists in San Fruttuoso bay with the ancient Abbey (San Fruttuoso di Capodimonte), X-XI century, and Andrea Doria tower. Portofino and Camogli, Genoa province, Liguria, Italy, Europe.
Photo of View of Pieve Ligure and on Sori on the background, italian towns of ligurian riviera, Genoa (Genova) province, Italy.
photo of view of Bogliasco, Genoa, Italy town skyline on the Mediterranean sea at sunset.
Photo of Portofino in Italy by Pascvii
Aerial view at tower of Pisa in Italy on a sunny day.
Tourist female in Pisa, Arno river, lamp and buildings reflection. Lungarno view.santa maria della spina
Blue hour twilight with Duomo and world famous Leaning Tower travel background in Tuscany.
Landscape with Pisa old town and Arno river, Tuscany, Italy.
 Tourists and locals enjoy a sunny day on the Corso Italia, the main shopping and dining street through the Tuscan city of Pisa, Italy.
Gothic church of Santa Maria della Spina, built around 1230 in the Pisan Gothic style.
Building in botanical garden of Pisa (Orto botanico di Pisa) in Italy
Photo of Tourists at the Primatial Metropolitan Cathedral of the Assumption of Mary in Pisa.
Carriage with horse in front of the leaning tower of Pisa
San Miniato, Pisa, Tuscany, Italy: the ancient catholic theological seminary in the picturesque old town.
Piazza Vittorio Emanuele square in the centre of Pisa city in Tuscany, Italy
Beautiful building of University on Piazza dei Cavalieri (Palazzo della Carovana) decorated with sgraffiti and sculptures of Grand Dukes of Tuscany. The statue depicts Cosimo I de' Medici. Pisa, Italy
The Cittadella Nuova now called the Giardino di Scotto or Giardino Scotto is an old fortress in Pisa, Italy
Piazza dei Cavalieri, Palazzo della Carovana, Palazzo dell'Orologio in Pisa, Italy. Architecture and landmark of Pisa. Cityscape of Pisa
Pisa, Italy. Leaning Tower of Pisa. Panoramic view in the evening. Aerial view
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Experience the freedom of the open road in Italy as you embark on an unforgettable 5-day road trip! This experience caters to every traveler, featuring destinations like Genoa, Portofino, Corniglia, Pisa, Florence, and Lucca.

This perfectly planned road trip itinerary in Italy takes you through some of the best places to see in the country. You will spend 2 nights in Genoa, 1 night in Portofino, and 1 night in Pisa. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Italy. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have got you covered.

Upon arriving in Genoa, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Italy on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Italy. Ponte Vecchio and Leaning Tower Of Pisa are just a couple of the bucket-list attractions that await your discovery. Marvel at the remarkable Piazza Del Duomo, Pisa, learn more about the unique Uffizi Gallery, and immerse yourself in the vibrant atmosphere of Aquarium Of Genoa.

As you hit the open road and drive through Genoa, Portofino, Corniglia, Pisa, Florence, and Lucca, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Italy. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Italy.

Throughout your road trip in Italy, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Italy.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodation, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in Italy fill up quickly, so book your spot early. Select a date and start planning your road trip in Italy today!

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Driver’s age is 30 - 65
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Itinerary summary

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Days
Destination
Attractions
Overnight
Day
City & Overnight
Attractions
Aquarium of Genoa
piazza De FerrariGenoa CathedralDoge's PalaceVia GaribaldiGalata - Museo del mareArea Marina Protetta di Portofino
Cinque Terre National ParkLeaning Tower of PisaPiazza del Duomo, Pisa
Basilica of Santa Croce in FlorenceUffizi GalleryPonte VecchioWalls of Lucca
porto antico

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Day 1

Day 1

  • Genoa - Arrival day
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  • Aquarium of Genoa
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Your road trip adventure in Italy begins as soon as you reach Genoa and pick up your car. You’ll stay in Genoa for 1 night and explore the best things to see and do, sample the local cuisine, and choose from a curated selection of the best hotels and places to stay in the city.

Genoa is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out Aquarium Of Genoa, or just taking a stroll in the city center. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

Find your way to your hotel in Genoa. We recommend choosing a hotel in a central location for easy exploring. Check-in typically starts between 2 and 4 PM at hotels in Italy. Settle in and make plans for the evening.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Genoa, it's often a good idea to reserve a table in advance.

Dine in style at 7 Sensi cucina decontaminata, a top recommendation for dinner tonight. Or, for a change of pace, Alla Lunga Ristorante boasts a menu that's sure to impress. Also, be sure to check out Grand Hotel Savoia. Known as a local hotspot, it’s a great choice for tonight in Genoa.

Explore the vibrant nightlife at Scurreria Beer & Bagel after your meal, a hub for lively evenings and memorable moments. Or, head to La Lepre for a great selection of flavorful drinks and a charming setting. Furthermore, Bar Pisacane Iii is perfect for those looking to extend their night with a touch of local flavor.

Raise a toast to the start of your 5-day road trip in Italy!

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Day 2

Day 2

  • Genoa
  • Portofino
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Drive 58 km, 1 hour 51 min

  • piazza De Ferrari
  • Genoa Cathedral
  • Doge's Palace
  • Via Garibaldi
  • Galata - Museo del mare
  • Area Marina Protetta di Portofino
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Experience an unparalleled adventure on day 2 of your road trip in Italy. This exciting part of your journey invites you to discover the renowned landmarks in 2 vibrant destinations - Genoa and San Fruttuoso di Camogli. After a day filled with exploration and new experiences, you will retreat to the hotel of your choice in Portofino. You will spend 1 night here for some well-deserved relaxation.

Bring your curiosity for today’s adventure around Genoa. Some of the city’s most loved attractions await! Piazza De Ferrari is the perfect place to start. This public square is one of the most popular places to visit in Genoa. Next, head to Genoa Cathedral, a frequently visited church, known for its heritage-rich features.

Nearby, you'll also find Via Garibaldi and Galata Museo Del Mare (complex). Visit these for an interesting touch to your journey. Finish the day with a visit to Area Marina Protetta Di Portofino, a romantic nature reserve in Genoa.

When you’re done exploring for the day, you’ll drive to your hotel in Portofino. Check in and spend some time relaxing before you head out to tour the village.

As dinnertime approaches, it's time to head out for a bite to eat in Portofino. If you are looking to dine at a popular restaurant in the village, it's often a good idea to reserve a table in advance.

Treat yourself to a delicious dinner at Trattoria Concordia, an excellent option for tonight's dining. Looking for something different? Ristorante Da Ö Batti Portofino - Ristorante Da Ö Batti offers a tantalizing alternative with its diverse menu. And don’t miss Ristorante Puny. With its reputation for pleasing customers, it’s a fantastic choice for tonight in Portofino.

Savor another day of unforgettable experiences in Italy!

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Day 3

Day 3

  • Portofino
  • Pisa
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Drive 185 km, 3 hours 33 min

  • Cinque Terre National Park
  • Leaning Tower of Pisa
  • Piazza del Duomo, Pisa
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Dive into day 3 of your remarkable road trip in Italy. Today you will explore Corniglia and Pisa, where you will have the opportunity to experience all the top things to see and do. At the end of the day, you’ll unwind at one of the finest accommodations in Pisa. You’ll stay here for 1 night.

Brace yourself for today’s incredible lineup of attractions in Portofino, featuring family-friendly attractions, romantic experiences, and natural wonders. Start at Cinque Terre National Park, a locally renowned national park in the village. Then, head to Leaning Tower Of Pisa and soak in the ambiance of this culturally significant monument.

There are many interesting places to see in Portofino, and when you are ready for more, go to Piazza Del Duomo, Pisa. This is one of the village’s most globally renowned picture-perfect spots of interest.

After soaking up all the sights of today's itinerary, you'll be ready to head in the direction of your accommodation in Pisa. Pisa offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

As you explore more of Pisa, you'll discover that its culinary landscape is as diverse as its attractions. Whether you're craving traditional dishes bursting with local flavors or innovative creations that push the boundaries of taste, you're sure to find a dining experience that satisfies your cravings.

Make sure to reserve a table at Anima di Grano Pizzeria Napoletana Pisa Italy, an iconic dining spot in Pisa. This culinary treasure and its outstanding menu have enchanted food enthusiasts from around the world. Immerse yourself in the culinary delights of il Mercante, a popular restaurant in Pisa. With a menu designed to delight, it ensures a dining experience that transcends the ordinary. Experience the culinary magic of La Ghiotteria, a hidden gem nestled in Pisa. Known for its exquisite cuisine and inviting atmosphere, it's a dining experience you won't soon forget.

Keep the excitement of the evening going by visiting a bar or two. Jeffer Cocktails & Friends is an excellent place to start. You could also check out Le Parisien Wine Bar, offering a different kind of charm. A last recommendation for the day is Las Volta Cocktailbar. This bar promises an enjoyable experience with tasty drinks and a vibrant setting.

Say good night to Pisa and look forward to another great day of your road trip in Italy!

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Day 4

Day 4

  • Pisa
  • Genoa
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Drive 323 km, 4 hours 28 min

  • Basilica of Santa Croce in Florence
  • Uffizi Gallery
  • Ponte Vecchio
  • Walls of Lucca
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On day 4 of your exciting self-drive vacation in Italy, you’ll soak in the magnificence of 2 destinations, Florence and Lucca. When you’re not sightseeing, take time to relax at your selected hotel in Genoa, where you’ll be staying for 1 night.

Get ready for a day filled with family-friendly attractions, photo-friendly spots, and history-rich sites in the charming city of Pisa. Your adventure starts at Basilica Of Santa Croce In Florence, a notable local hot spot. Another notable attraction to explore is Uffizi Gallery. This impressive art gallery is known for its culturally significant appeal.

After soaking in the highlights of these sights, take some time to wander Pisa's streets and immerse yourself in the local atmosphere. When you're ready to continue your sightseeing adventure, head to Ponte Vecchio. This enchanting historical landmark offers a fascinating experience that many visitors find memorable. Mura Di Lucca is also worth visiting.

At the end of the day, you will drive to Genoa, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

After a day of adventure, treat yourself to an exquisite dinner at one of Genoa's best restaurants.

Enjoy a lovely meal at Zeffirino, a top-rated place to have dinner tonight. Alternatively, if your taste buds call for something different, Trattoria Vegia Zena is another top choice with a popular menu. You could also check for a table at Trattoria delle Grazie. As an establishment that gains consistently high praises from customers, it’s an ideal choice in Genoa tonight.

Celebrate another amazing day of your road trip adventure in Italy!

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Day 5

Day 5

  • Genoa - Departure day
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  • porto antico
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Day 5 of your road trip in Italy is your departure day. This is your chance to catch a last glimpse of Genoa before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

If you're up for some more sightseeing, we recommend visiting Porto Antico, a romantic public square before you head out.

Maximize your last day in Italy and go on a shopping spree in Genoa’s shopping center, the lively Via Garibaldi. Browse for souvenirs to remind you of your wonderful journey in Italy.

Before you conclude your road trip in Italy, drop by another restaurant for a last chance at a memorable dining experience in Genoa.

If you're in the mood for something new, try La Cialtroneria, another premier location with a delectable menu.

You’ll then say farewell to Genoa. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Italy!

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