5-Day Sicily Self-Drive Road Trip With Itinerary from Palermo to Agrigento and Taormina

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Photo of Palermo, Sicily, Italy. Seafront view.
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Explore the best of Sicily on a remarkable 5-day road trip! Combine exploration with relaxation on a self-drive tour featuring Palermo, Agrigento, Piazza Armerina, Taormina, Syracuse, and Cefalù.

This perfectly planned road trip itinerary takes you through some of the best places to see in Sicily. You will spend 2 nights in Palermo, 1 night in Agrigento, and 1 night in Taormina. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Sicily. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have you covered.

Upon arriving in Palermo, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Sicily on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Sicily. Valle Dei Templi and Palermo Cathedral are just a couple of the bucket-list attractions that await your discovery. Marvel at the remarkable Ancient Theatre Of Taormina, learn more about the unique Quattro Canti, and immerse yourself in the vibrant atmosphere of Norman Palace.

As you hit the open road and drive through Palermo, Agrigento, Piazza Armerina, Taormina, Syracuse, and Cefalù, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Sicily. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Sicily.

Throughout your road trip in Sicily, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Sicily.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodations, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in Sicily fill up quickly, so book your spot early. Select a date and start planning your road trip in Sicily today!

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Driver’s age is 30 - 65
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Pick-up: 10:00
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Day 1

Day 1

  • Palermo - Arrival day
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  • Foro Italico
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Welcome to Palermo, the perfect starting point for your road trip in Italy! Pick up your rental car and let the adventure begin. You will spend 1 night discovering what to see in Palermo before embarking on the next leg of your journey.

Palermo is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out Foro Italico, or just taking a stroll in the city center. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

When you're ready for some downtime, make your way to your chosen hotel. Check-in typically starts between 2 and 4 PM in Palermo. Make yourself at home and unwind before heading out again.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Palermo, it's often a good idea to reserve a table in advance.

Dine in style at Cotto e Bollito, a top recommendation for dinner tonight. Or, for a change of pace, Bebop boasts a menu that's sure to impress. Also, be sure to check out Eremiti Restaurant. Known as a local hotspot, it’s a great choice for tonight in Palermo.

Cap off your dinner by heading to Malox Cult, ideal for a leisurely evening with a drink in hand. Ai Giudici is another bar that offers an enjoyable setting. Similarly, Bar Italico is also a popular place to go on a night out, perfect for relaxing and socializing.

Raise a toast to the start of your 5-day road trip in Sicily!

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Day 2

Day 2

  • Palermo
  • Agrigento
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Drive 138 km, 2 hours 53 min

  • Norman Palace
  • Palermo Cathedral
  • Quattro Canti
  • Fontana Pretoria
  • Orto botanico di Palermo
  • Valle dei Templi
  • More

On day 2 of your road trip in Sicily, your travel plans include 2 stops at the most scenic, wondrous, and interesting places in the region. Palermo and Agrigento are on today's agenda. In the evening, you’ll end up in Agrigento, where you will stay for 1 night.

Start your day at Norman Palace. This awe-inspiring palace is an interesting place to see in Palermo. Then, wander over to Palermo Cathedral. If grand sites excite you, this church will be right up your alley. Nearby, you’ll also find Quattro Canti. This symbolic public square is a favorite among visitors.

Palermo offers plenty to explore, ensuring every moment of your visit is filled with excitement and discovery. If you're up for more, Fontana Pretoria is a curiosity-inducing spot in the city that will captivate you with its unique charm. When you’re done at the monument, don’t forget to check out the serene Orto Botanico Di Palermo. Take a moment to appreciate the fascinating details of this frequently visited botanical garden. Wrap up your self-guided tour of Palermo's top attractions with a visit to Valle Dei Templi.

After soaking up all the sights on today's itinerary, you'll be ready to head to your accommodation in Agrigento. Agrigento offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Agrigento. Enjoy a relaxing evening as you savor delicious local cuisine.

Savor the flavors at Ambasciata di Sicilia, a top pick for dinner tonight. Alternatively, Le Cuspidi beckons with its unique menu offerings. Also, consider Yellove RistoVintage. With its consistent customer satisfaction, it’s an excellent option for dining in Agrigento tonight.

Head back to your accommodation in Agrigento and get some rest to prepare for another magical day of your road trip in Sicily.

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Day 3

Day 3

  • Agrigento
  • Taormina
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Drive 252 km, 4 hours 32 min

  • Villa Romana del Casale
  • Grotta Azzurra
  • Villa Comunale di Taormina
  • Ancient theatre of Taormina
  • Porta Catania
  • Basilica of St. Nicholas of Bari
  • More

On day 3 of your exciting self-drive vacation in Sicily, you’ll soak in the magnificence of 3 destinations, including Piazza Armerina, Mazzarò, and Taormina. When you’re not sightseeing, take time to relax at your chosen hotel in Taormina, where you’ll be staying for 1 night.

One of the most notable attractions included on the itinerary is Villa Romana Del Casale. This UNESCO world heritage-listed archeological site will help you start your sightseeing on top. Then, take a leisurely stroll to Grotta Azzurra and learn what makes this mesmerizing cave unique.

Throughout the day, make sure to take breaks to appreciate the surroundings. Next up, visit the beloved Villa Comunale Di Taormina. After exploring the park, head to Ancient Theatre Of Taormina. This captivating archeological site is a highlight in Agrigento. As your day continues, stop by Porta Catania, known for its respected features. Lastly, don’t forget to check out the increasingly popular Basilica Of St. Nicholas Of Bari. Enjoy exploring this incredible church at your own pace.

When you’re done exploring for the day, you’ll drive to your hotel in Taormina. Check in and relax before you head out to tour the town.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Taormina. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Enjoy a lovely dining experience at PizzaMania Taormina, a popular restaurant in Taormina. This acclaimed establishment has earned the admiration of countless food lovers in the city. Alternatively, experience a taste of Taormina at Ristorante Pizzeria Tiramisù Taormina, another great place to eat. With a menu designed to impress, it promises a journey of flavors that will leave you captivated. A third option to check out is the top-rated La Pignolata Guinness Cannoli Taormina since 1978 N°15. It’s yet another ideal choice to enhance your time in Taormina tonight.

Let the evening flow smoothly from dinner to drinks at Luraleo Bar, a top-rated bar in the area. For other recommendations, Don Diego Gelateria Caffetteria provides a perfect setting for rounding out your night with style and great drinks.

As the day draws to a close, take a moment to unwind and prepare for the next exciting chapter of your road trip in Sicily.

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Day 4

Day 4

  • Taormina
  • Palermo
  • More

Drive 424 km, 5 hours 25 min

  • Ear of Dionysius
  • Neapolis Archaeological Park
  • Temple of Apollo
  • Cathedral of Cefalù
  • Lavatoio Medievale Fiume Cefalino - Cefalù (pa)
  • More

Experience an unparalleled adventure on day 4 of your road trip in Sicily. This exciting part of your journey invites you to discover the renowned landmarks in 2 places, which are Syracuse and Cefalù. At the end of the day, you will retreat to the hotel of your choice in Palermo, where will spend 1 night.

Let Ear Of Dionysius set the tone for the day. Spend some time admiring this eye-catching cave before continuing your journey. Neapolis Archaeological Park is your next stop. This locally renowned archeological site is one of the best-rated sights in Taormina.

Consider grabbing some lunch or a light snack to keep your energy going. Beyond the above-mentioned attractions, today is also the perfect time to visit Temple Of Apollo. This standout archeological site is a sight to behold. To round off your sightseeing experience, visit Cefalù Cathedral and Lavatoio Medievale Fiume Cefalino - Cefalù (pa).

At the end of the day, you will drive to Palermo, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

Palermo is a place where the culinary landscape is as diverse as its attractions. So before the day ends, treat your palate to a taste of local cuisine at one of the best restaurants in Palermo.

Have a fantastic dining experience at Osteria Mercede, a highly recommended choice for tonight's dinner. If you're looking to mix things up, Trattoria Del Massimo offers an enticing alternative with its varied menu. Additionally, Grand Hotel Piazza Borsa is worth considering. Renowned for satisfying diners, it’s an ideal option for tonight in Palermo.

Continue the enjoyment post-dinner at Spina Bar Palermo, a cherished local gathering spot renowned for its welcoming atmosphere. Similarly, Torrefazione Castagnetta Massimiliano (gelateria) offers a vibrant space for indulging in well-crafted drinks and engaging conversation. You may also want to check out Monkey Pub. This bar is a favorite among both locals and visitors looking for a delightful evening out filled with laughter and fun.

Raise your glass and celebrate another amazing day of your road trip in Sicily!

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Day 5

Day 5

  • Palermo - Departure day
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  • Catacombe dei Cappuccini
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Day 5 of your road trip in Sicily is your departure day. This is your chance to catch a last glimpse of Palermo before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

If you're up for some more sightseeing, begin at Catacombe Dei Cappuccini. This well-known cemetery is a hotspot among locals.

Before you conclude your road trip in Sicily, drop by another restaurant for a last chance at a memorable dining experience in Palermo.

You’ll then say farewell to Palermo. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Sicily!

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Shortly after booking, you’ll receive your full itinerary, including schedules, locations, and everything you need for a stress-free trip.
Personalize your itinerary
Each package includes a professionally crafted itinerary you can tailor to your travel style. A dedicated travel expert will make sure every detail fits your needs perfectly.
Easily make changes
Need to update plans? No problem. Whether before your trip or mid-journey, we’re just seconds away to help with quick adjustments.
Enjoy seamless planning
With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.
Explore with confidence
From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.
Secure your spot
Confirm your package instantly and lock in the best rate with secure payment and guaranteed availability.
Get instant confirmation
Shortly after booking, you’ll receive your full itinerary, including schedules, locations, and everything you need for a stress-free trip.
Personalize your itinerary
Each package includes a professionally crafted itinerary you can tailor to your travel style. A dedicated travel expert will make sure every detail fits your needs perfectly.
Easily make changes
Need to update plans? No problem. Whether before your trip or mid-journey, we’re just seconds away to help with quick adjustments.
Enjoy seamless planning
With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.
Explore with confidence
From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.

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Your trip is protected, personalized, and priced right. No surprises, no stress.

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