5-Day Sicily Self-Drive Road Trip With Itinerary from Palermo to Agrigento and Taormina

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Photo of Palermo, Sicily, Italy. Seafront view.
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Experience the freedom of the open road in Sicily as you embark on an unforgettable 5-day road trip! This experience caters to every traveler, featuring destinations like Palermo, Agrigento, Piazza Armerina, Taormina, Syracuse, and Cefalù.

This perfectly planned road trip itinerary in Sicily takes you through some of the best places to see in the country. You will spend 2 nights in Palermo, 1 night in Agrigento, and 1 night in Taormina. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Sicily. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have got you covered.

Upon arriving in Palermo, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Sicily on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Sicily. Valle Dei Templi and Palermo Cathedral are just a couple of the bucket-list attractions that await your discovery. Marvel at the remarkable Ancient Theatre Of Taormina, learn more about the unique Quattro Canti, and immerse yourself in the vibrant atmosphere of Norman Palace.

As you hit the open road and drive through Palermo, Agrigento, Piazza Armerina, Taormina, Syracuse, and Cefalù, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Sicily. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Sicily.

Throughout your road trip in Sicily, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Sicily.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodation, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in Sicily fill up quickly, so book your spot early. Select a date and start planning your road trip in Sicily today!

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Day 1

Day 1

  • Palermo - Arrival day
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  • Foro Italico
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Your road trip adventure in Sicily begins as soon as you reach Palermo and pick up your car. You’ll stay in Palermo for 1 night and explore the best things to see and do, sample the local cuisine, and choose from a curated selection of the best hotels and places to stay in the city.

Palermo is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out Foro Italico, or just taking a stroll in the city center. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

Make your way to your chosen hotel. Check-in typically starts between 2 and 4 PM in Palermo. Make yourself at home and enjoy some downtime before heading out again.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Palermo, it's often a good idea to reserve a table in advance.

Treat yourself to a wonderful meal at Cotto e Bollito, a top-rated dining spot in Palermo. If you're in the mood for something new, try Bebop, another premier location with a delectable menu. You might also want to book a table at Eremiti Restaurant. Known for its consistently satisfied patrons, it’s a perfect choice to elevate your evening in Palermo.

Unwind after your meal by stepping into Malox Cult. This venue is celebrated for its extensive drink selections and cozy vibes. Alternatively, Ai Giudici offers a dynamic and energetic atmosphere for a glass or two. Don’t overlook Bar Italico, another top-rated bar in the area.

Raise a toast to the start of your 5-day road trip in Sicily!

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Day 2

Day 2

  • Palermo
  • Agrigento
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Drive 138 km, 2 hours 53 min

  • Norman Palace
  • Palermo Cathedral
  • Quattro Canti
  • Fontana Pretoria
  • Orto botanico di Palermo
  • Valle dei Templi
  • More

Embark on another extraordinary experience on day 2 of your road trip in Sicily. Today, you will make 2 stops and experience some of the highlights of Palermo and Agrigento. At the end of the day, you will enjoy the comforts of a top-rated hotel in Agrigento, which will be your home away from home for 1 night.

Enjoy the perfect balance of relaxation and exploration in Palermo today. One of the most locally renowned attractions included on the itinerary is Norman Palace. This historic palace will help you start your sightseeing on top. Then, take a leisurely stroll to Palermo Cathedral and learn what makes this breathtaking church unique.

Throughout the day, make sure to take breaks to appreciate the surroundings. Next up, visit the popular Quattro Canti. After exploring the public square, head to Fontana Pretoria. This underrated monument is a highlight in Palermo. As your day continues, stop by Orto Botanico Di Palermo, known for its romantic features. Lastly, don’t forget to check out the locally renowned Valle Dei Templi. Enjoy exploring this incredible archeological site at your own pace.

When you’re done exploring for the day, you’ll drive to your hotel in Agrigento. Check in and spend some time relaxing before you head out to tour the city.

After a long day of exploring, sit down for a delicious dinner at a top-rated restaurant in Agrigento. Enjoy a satisfying meal that will recharge you for tonight's adventures.

Treat yourself to a delightful dinner at Ambasciata di Sicilia, highly recommended for tonight's dining. Or, if you're feeling adventurous, why not try Le Cuspidi? It's another excellent option with a diverse menu. Consider reserving a table at Yellove RistoVintage as well. Known for its consistent customer satisfaction, it’s an ideal pick for tonight in Agrigento.

Relax and reminisce about your day in Sicily and look forward to more memorable moments to come!

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Day 3

Day 3

  • Agrigento
  • Taormina
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Drive 252 km, 4 hours 32 min

  • Villa Romana del Casale
  • Grotta Azzurra
  • Villa Comunale di Taormina
  • Ancient theatre of Taormina
  • Porta Catania
  • Basilica of St. Nicholas of Bari
  • More

On day 3 of your road trip in Sicily, you will get a true taste of the freedom a self-drive vacation in Europe entails. Today’s travel plans include stops at the most scenic, wondrous, and interesting places in Piazza Armerina, Mazzarò, and Taormina. In the evening, you’ll end up in Taormina, where you will stay for 1 night.

Agrigento is home to plenty of attractions that offer fun adventures, scenic views, and photo-friendly spots! Start at Villa Romana Del Casale, a notable archeological site that is worthwhile a visit in the town. Nearby, you’ll find Grotta Azzurra, enchanting visitors with its serene appeal. Continue your exploration at Villa Comunale Di Taormina. This park is one of the town’s most locally appreciated spots.

Enjoy the freedom of exploring Agrigento at your own pace and find hidden gems along the way. If you want to see more picture-perfect spots, make sure to visit Ancient Theatre Of Taormina. After exploring the archeological site, head to the increasingly popular Porta Catania. Lastly, wrap up today’s self-guided sightseeing tour with a visit to Basilica Of St. Nicholas Of Bari, a place of culturally significant interest in Agrigento.

At the end of the day, you will drive to Taormina, where you'll have a room waiting for you at the perfect place to stay. Check in and enjoy some downtime.

As you are wrapping up for the day, treat yourself to a satisfying dinner at a nice restaurant in Taormina. Enjoy a relaxing evening as you savor delicious local cuisine and reflect on the day's adventures.

Treat yourself to a wonderful meal at PizzaMania Taormina, a top-rated dining spot in Taormina. If you're in the mood for something new, try Ristorante Pizzeria Tiramisù Taormina, another premier location with a delectable menu. You might also want to book a table at La Pignolata Guinness Cannoli Taormina since 1978 N°15. Known for its consistently satisfied patrons, it’s a perfect choice to elevate your evening in Taormina.

After enjoying a delightful dinner, why not delve into the vibrant local bar scene? You might want to spend the evening at Luraleo Bar, a well-loved spot among locals and tourists. Or, head to Don Diego Gelateria Caffetteria. This bar boasts a welcoming environment that is perfect for winding down.

Raise your glass and celebrate another amazing day of your road trip in Sicily!

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Day 4

Day 4

  • Taormina
  • Palermo
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Drive 424 km, 5 hours 25 min

  • Ear of Dionysius
  • Neapolis Archaeological Park
  • Temple of Apollo
  • Cathedral of Cefalù
  • Lavatoio Medievale Fiume Cefalino - Cefalù (pa)
  • More

On day 4 of your exciting self-drive vacation in Sicily, you’ll soak in the magnificence of 2 destinations, Syracuse and Cefalù. When you’re not sightseeing, take time to relax at your selected hotel in Palermo, where you’ll be staying for 1 night.

Discover a day packed with fun adventures, breathtaking views, and picturesque spots in Taormina. Begin your sightseeing with Ear Of Dionysius. This underrated cave is one of the top attractions in the city. Proceed to Neapolis Archaeological Park, another must-visit attraction.

As you wander through the inviting streets of Taormina, soak in the lively ambiance and take the opportunity to snap some photos. Next, head to Temple Of Apollo. This notable archeological site is a traveler-favorite. Not far away, you’ll find Cefalù Cathedral, another key site on your sightseeing itinerary. Lavatoio Medievale Fiume Cefalino - Cefalù (pa) is yet another highly recommended place to visit nearby, offering plenty to discover for curious travelers.

After soaking up all the sights of today's itinerary, you'll be ready to head in the direction of your accommodation in Palermo. Palermo offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

After a day of adventure, treat yourself to an exquisite dinner at one of Palermo's best restaurants.

Enjoy a lovely meal at Osteria Mercede, a top-rated place to have dinner tonight. Alternatively, if your taste buds call for something different, Trattoria Del Massimo is another top choice with a popular menu. You could also check for a table at Grand Hotel Piazza Borsa. As an establishment that gains consistently high praises from customers, it’s an ideal choice in Palermo tonight.

After your meal, keep the night alive at a bar like Spina Bar Palermo, known for its lively atmosphere. Torrefazione Castagnetta Massimiliano (gelateria) is another top recommendation that provides the perfect setting with well-crafted drinks and a welcoming ambiance. Similarly, Monkey Pub offers an excellent atmosphere for those looking to amp up the evening.

As the day draws to a close, take a moment to unwind and prepare for the next exciting chapter of your road trip in in Sicily.

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Day 5

Day 5

  • Palermo - Departure day
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  • Catacombe dei Cappuccini
  • More

Day 5 of your road trip in Sicily is your departure day. This is your chance to catch a last glimpse of Palermo before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

If you're up for some more sightseeing, begin at Catacombe Dei Cappuccini. This notable cemetery is a popular place to see in the city.

Explore local shops for souvenirs to remember your trip or find unique gifts for loved ones.

Before you conclude your road trip in Sicily, drop by another restaurant for a last chance at a memorable dining experience in Palermo.

You’ll then say farewell to Palermo. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Sicily!

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Shortly after booking, you’ll receive your full itinerary, including schedules, locations, and everything you need for a stress-free trip.
Personalize your itinerary
Each package includes a professionally crafted itinerary you can tailor to your travel style. A dedicated travel expert will make sure every detail fits your needs perfectly.
Easily make changes
Need to update plans? No problem. Whether before your trip or mid-journey, we’re just seconds away to help with quick adjustments.
Enjoy seamless planning
With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.
Explore with confidence
From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.
Secure your spot
Confirm your package instantly and lock in the best rate with secure payment and guaranteed availability.
Get instant confirmation
Shortly after booking, you’ll receive your full itinerary, including schedules, locations, and everything you need for a stress-free trip.
Personalize your itinerary
Each package includes a professionally crafted itinerary you can tailor to your travel style. A dedicated travel expert will make sure every detail fits your needs perfectly.
Easily make changes
Need to update plans? No problem. Whether before your trip or mid-journey, we’re just seconds away to help with quick adjustments.
Enjoy seamless planning
With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.
Explore with confidence
From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.

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Your trip is protected, personalized, and priced right. No surprises, no stress.

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