5-Day Sicily Self-Drive Road Trip With Itinerary from Palermo to Agrigento and surrounding area

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Photo of Palermo, Sicily, Italy. Seafront view.
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Escape the ordinary with this exciting 5-day road trip through Sicily. Explore diverse landscapes, discover lively cities, and prepare for an unforgettable journey!

This perfectly planned road trip itinerary takes you through some of the best places to see in Sicily. You will spend 3 nights in Palermo and 1 night in Agrigento. Anticipate well-spent days sightseeing, eating delicious food, and experiencing the highlights of each destination!

With this travel package, you can choose from an extensive selection of accommodations along your road trip route in Sicily. We have handpicked the best hotels and places to stay across the country, including options for each budget. Whether you are in the mood for luxurious 5-star hotels or budget-friendly bed and breakfasts, we have you covered.

Upon arriving in Palermo, the rental vehicle of your choice will be ready for collection. From there, the road trip can begin! Experience the ultimate freedom and uncover Sicily on your own terms.

An expertly curated travel plan makes sure you don’t miss out on any of the best things to see and do on your road trip in Sicily. Palermo Cathedral and Quattro Canti are just a couple of the bucket-list attractions that await your discovery.

As you hit the open road and drive through Palermo, Agrigento, Xitta, and Castellammare del Golfo, you will also enjoy plenty of opportunities to uncover hidden gems and experience the authentic charm of Sicily. Whether you are exploring enchanting towns and villages, discovering scenic routes, or indulging in local cuisine, there is always something new and exciting to experience in Sicily.

Throughout your road trip in Sicily, take breaks from sightseeing to explore your favorite destinations' top shopping streets and markets. Discover unique souvenirs that will forever remind you of your self-drive adventure in Sicily.

This package offers an all-in-one solution for your trip planning - choose flights, a rental car, accommodations, attractions, and tours that suit your needs and desires. You can customize each day of your road trip itinerary with flexible trip planning before and after booking.

The best services in Sicily fill up quickly, so book your spot early. Select a date and start planning your road trip in Sicily today!

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Driver’s age is 30 - 65
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Day1

Day 1

  • Palermo - Arrival day
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  • Foro Italico
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Say hello to Palermo! Your exciting road trip through Italy is just about to start. Navigating the top places to see in the region is a breeze with a car. The rental vehicle of your choice will be ready for pickup upon your arrival in the city. You will stay in Palermo for 2 nights before you continue your adventure!

Palermo is a beautiful city with plenty to discover. If you arrive before check-in time or prefer to get started on your sightseeing right away, we recommend checking out Foro Italico. Taking a stroll in the city center is a great alternative. Soak in the lovely atmosphere and sit down for a bit to eat or drink.

As afternoon approaches, head to your chosen hotel in Palermo. Check-in typically starts around 2 to 4 PM at hotels in Italy. We recommend staying at a central location for easy access to key areas in the city.

As dinnertime approaches, it's time to head out for a bite to eat. If you are looking to dine at a popular restaurant in Palermo, it's often a good idea to reserve a table in advance.

Enjoy a lovely dining experience at Cotto e Bollito, a popular restaurant in Palermo. This acclaimed establishment has earned the admiration of countless food lovers in the city. Alternatively, experience a taste of Palermo at Bebop, another great place to eat. With a menu designed to impress, it promises a journey of flavors that will leave you captivated. A third option to check out is the top-rated Eremiti Restaurant. It’s yet another ideal choice to enhance your time in Palermo tonight.

Extend your evening after a delightful meal by visiting Malox Cult, which offers the perfect atmosphere for a night out. Moreover, Ai Giudici is another popular option for a drink or two. Likewise, Bar Italico also provides a great ambiance for reminiscing about the day and raising a toast to your vacation.

Raise a toast to the start of your 5-day road trip in Sicily!

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Day2

Day 2

  • Palermo
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Drive 50 km, 2 hours 10 min

  • Fontana Pretoria
  • Quattro Canti
  • Church of St. Mary of the Admiral
  • Riserva Naturale di Capo Gallo
  • Santuario di Santa Rosalia, Palermo
  • More

Day 2 of your road trip will take you to the best attractions Palermo has to offer. Cherish the 1 night you have left in the city and use the provided itinerary to discover what to see in Palermo.

Make time for Fontana Pretoria, an intriguing monument that is worthwhile a visit in the city. Nearby, you’ll find Quattro Canti, enchanting visitors with its visually striking appeal. Continue your exploration at Martorana. This church is one of the city’s most underrated spots.

Enjoy the freedom of exploring Palermo at your own pace and find hidden gems along the way. If you want to see more picture-perfect spots, make sure to visit Riserva Naturale Di Capo Gallo. After exploring the nature reserve, head to the underrated Santuario Di Santa Rosalia, Palermo.

Don’t forget to check out all the popular tours and experiences you can add to your travel plans in Sicily. You can explore and select activities under each day of your itinerary.

Indulge in a memorable dining experience at one of Palermo's most popular restaurants, and connect with friendly locals for a true cultural experience.

Treat yourself to an extraordinary dining experience at Buatta Cucina Popolana, a Bib Gourmand restaurant offering an incredible sicilian menu. Alternatively, if your taste buds call for something different, Mec Restaurant is one of the best restaurants for sicilian and contemporary cuisine in Palermo. This 1-star Michelin-awardee earns consistently high praises from guests. We also recommend checking out the menu at Gagini Restaurant. As a top-rated establishment with 1 Michelin star, it is an ideal choice for creative and contemporary cuisine in the city.

Extend your evening after a delightful meal by visiting Spina Bar Palermo, which offers the perfect atmosphere for a night out. Moreover, Torrefazione Castagnetta Massimiliano (gelateria) is another popular option for a drink or two. Likewise, Monkey Pub also provides a great ambiance for reminiscing about the day and raising a toast to your vacation.

Raise your glass to another unforgettable day in Sicily!

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Day3

Day 3

  • Palermo
  • Agrigento
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Drive 137 km, 2 hours 31 min

  • Norman Palace
  • Palermo Cathedral
  • Orto botanico di Palermo
  • Catacombe dei Cappuccini
  • More

On day 3 of your exciting self-drive vacation in Sicily, you’ll soak in the magnificence of 1 destination, including Palermo. When you’re not sightseeing, take time to relax at your chosen hotel in Agrigento, where you’ll be staying for 1 night.

Experience Norman Palace, a notable palace in the city. Then, head to Palermo Cathedral and soak in the ambiance of this picture-perfect church.

There are many interesting places to see in Palermo, and when you are ready for more, go to Orto Botanico Di Palermo. This is one of the city’s most worthwhile stunning spots of interest. After exploring the botanical garden, visit the captivating Catacombe Dei Cappuccini.

When you’re done exploring for the day, you’ll drive to your hotel in Agrigento. Check in and relax before you head out to tour the city.

Agrigento is a place where the culinary landscape is as diverse as its attractions. So before the day ends, treat your palate to a taste of local cuisine at one of the best restaurants in Agrigento.

Treat yourself to a wonderful meal at Ambasciata di Sicilia, a top-rated dining spot in Agrigento. If you're in the mood for something new, try Le Cuspidi, another premier location with a delectable menu. You might also want to book a table at Yellove RistoVintage. Known for its consistently satisfied patrons, it’s a perfect choice to elevate your evening in Agrigento.

Take some time to reflect on your day and savor another beautiful night in Sicily.

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Day4

Day 4

  • Agrigento
  • Xitta
  • Castellammare del Golfo
  • Palermo
  • More

Drive 312 km, 4 hours 40 min

  • Saline di Trapani e Paceco
  • Riserva Naturale Orientata dello Zingaro
  • Belvedere Castellammare del Golfo
  • Marina di Castellammare del Golfo
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Your itinerary for day 4 of your road trip in Sicily includes 3 stops and features some of the highlights of Xitta, San Vito Lo Capo, and Castellammare del Golfo. At the end of the day, enjoy the comforts of a top-rated hotel in Palermo, where you'll spend 1 night.

After soaking in Agrigento’s unique atmosphere, jump into the car with a full heart and drive in the direction of your next destination: Xitta. Expect your car journey to take a minimum of 2 hours 8 min. When you arrive in Xitta, it's time to take a break from the road.

Saline Di Trapani E Paceco is a beloved nature reserve we recommend visiting today. Discover its eye-catching features before continuing your self-guided tour.

When you’re ready to jump back into the car and say goodbye to Xitta, you’ll hit the road in the direction of San Vito Lo Capo. This drive usually takes around 47 min.

One of our top recommendations for your sightseeing is Riserva Naturale Orientata Dello Zingaro, Ingresso Sud. Spend some time admiring the romantic features of the nature reserve before you continue to your next stop.

Fasten your seatbelt and make your way to your next stop — Castellammare del Golfo, home to many well-known sights in the region. Keep in mind that your travel time from San Vito Lo Capo to Castellammare del Golfo may take around 24 min without traffic disruptions. Upon arrival in Castellammare del Golfo, we highly recommend checking out some of the top attractions.

Savor the day by heading to Belvedere Castellammare Del Golfo, a worthwhile observation deck that draws visitors from near and far. When you're done, continue to Marina Di Castellammare Del Golfo, where you can soak in the gorgeous surroundings.

After soaking up all the sights on today's itinerary, you'll be ready to head to your accommodation in Palermo. Palermo offers plenty of top-rated hotels for every travel budget. Take some time to relax before you go out again.

After a day of adventure, treat yourself to an exquisite dinner at one of Palermo's best restaurants.

Have a fantastic dining experience at Splendid Hotel la Torre, a highly recommended choice for tonight's dinner. If you're looking to mix things up, Ristorantino Sobremesa offers an enticing alternative with its varied menu. Additionally, Ristorante Quattro mani is worth considering. Renowned for satisfying diners, it’s an ideal option for tonight in Palermo.

After savoring a delicious meal, step into the vibrant nightlife at Bar Touring, where the evening is just getting started. In the same way, Palermo Football Store offers a unique charm perfect for experiencing the local bar scene in Palermo. Goccio - L’arte Del Miscelare is another top-recommended bar that is sure to get you into the mood for some dancing and celebrating.

Raise your glass to another unforgettable day in Sicily!

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Day5

Day 5

  • Palermo - Departure day
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  • Garden Zisa
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Day 5 of your road trip in Sicily is your departure day. This is your chance to catch a last glimpse of Palermo before saying goodbye to this wonderful destination. If you've still got time left, we recommend doing some last-minute shopping or sightseeing.

If you're up for some more sightseeing, we recommend visiting Giardino Della Zisa, a grand park before you head out.

Before you conclude your road trip in Sicily, drop by another restaurant for a last chance at a memorable dining experience in Palermo.

If you're eager to try something different, consider Villa Boscogrande - Chef Natale Di Maria, another top spot with a tantalizing menu.

You’ll then say farewell to Palermo. Drive to the airport, return your car, and take the opportunity to get some last-minute souvenirs before you board your flight home. We wish you a pleasant journey and hope you leave with many wonderful memories of your road trip in Sicily!

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Shortly after booking, you’ll receive your full itinerary, including schedules, locations, and everything you need for a stress-free trip.
Personalize your itinerary
Each package includes a professionally crafted itinerary you can tailor to your travel style. A dedicated travel expert will make sure every detail fits your needs perfectly.
Easily make changes
Need to update plans? No problem. Whether before your trip or mid-journey, we’re just seconds away to help with quick adjustments.
Enjoy seamless planning
With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.
Explore with confidence
From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.
Secure your spot
Confirm your package instantly and lock in the best rate with secure payment and guaranteed availability.
Get instant confirmation
Shortly after booking, you’ll receive your full itinerary, including schedules, locations, and everything you need for a stress-free trip.
Personalize your itinerary
Each package includes a professionally crafted itinerary you can tailor to your travel style. A dedicated travel expert will make sure every detail fits your needs perfectly.
Easily make changes
Need to update plans? No problem. Whether before your trip or mid-journey, we’re just seconds away to help with quick adjustments.
Enjoy seamless planning
With everything from accommodations to activities pre-arranged, our packages save you hours of research—so you can spend more time enjoying your trip, not planning it.
Explore with confidence
From scenic road trips to city-hopping adventures, we’re here 24/7 to support you across Europe—before, during, and after your trip.

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Your trip is protected, personalized, and priced right. No surprises, no stress.

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